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Gene Dmel\MED17

General Information
Symbol	Dmel\MED17	Species	D. melanogaster
Name	Mediator complex subunit 17	Annotation symbol	CG7957
Feature type	protein_coding_gene	FlyBase ID	FBgn0038578
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	Trap80, dTRAP80, l(3)s2956
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	90F6-90F6	Sequence location	3R:14,014,794..14,016,987 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Mediator complex subunit 17 is referred to in FlyBase by the symbol Dmel\MED17 (CG7957, FBgn0038578). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: RNA polymerase II transcription cofactor activity; activating transcription factor binding; transcription coactivator activity. There is experimental evidence that it is involved in the biological process: positive regulation of transcription from RNA polymerase II promoter; cellular process; sex comb development; mitotic G2 DNA damage checkpoint; regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter. 9 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Mediator complex, subunit Med17. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system. Comments on Affy2 ProbeSet: ProbeSet 1625217_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of MED17. Gene sequence location is 3R:14014794..14016987.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 90F6-90F6   Limits computationally determined from genome sequence between P{EP}cpoEP3679 and P{EP}Dlc90FEP3634
Experimentally Determined Cytological Location
Cytogenetic map Notes References 90E6-90F1     (Southworth, 2000.7.26) 90F1-90F2     (Bourbon, 2000.3.13) 90F1-90F2   (determined by in situ hybridisation)   (Spradling et al., 1999) 90F1-90F2     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\MED17 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) MED17-RA FBtr0083558  NM_142429   2060   642
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein MED17-PA   FBpp0082980   71.6   642   7.40     NP_650686   AAF55506
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Mediator complex, subunit Med17 (IPR019313)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA142021   AA142023   AE014297 AAF55506   AF244916 AAF63336   AF289995 AAG02460   AI543317   AQ026391   AW944616   AY118662 AAM50031   BF488143   BF490761   BI355750   BI574791   BI576272   BI620313   BI623551   CO179876   CO190101   CO190102   CO266504   CO344274   EC061435   EC223922   EC229879   EC235485   EC253880   GH941250   GH943044   GH943719   GH946483   GH948889   GH949590   GH951939   GH954478   GH965659   GH975686   GH978691   GH981668   GH981827
UniProtKB/Swiss-Prot	Q9VEC1
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   anterior endoderm anlage   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   antennal primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium central brain primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium visual primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium dorsal head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium lateral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium ventral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium anterior endoderm   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) central brain primordium   (Fisher et al., 2012) embryonic central brain glial cell   (Fisher et al., 2012) embryonic central brain neuron   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) procephalic neuroblast   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) embryonic/larval nervous system   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
mediator complex inferred from direct assay (Gu et al., 2002) inferred from direct assay (assigned by UniProtKB) (Park et al., 2001) nucleus inferred from direct assay (Gu et al., 2002, Park et al., 2003)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    117.6 Larval Midgut    37.9 Larval Hindgut    54.8 Larval Malpighian Tubules    75.9 Larval Fat Body    46.4 Larval Salivary Gland    76.5 Larval Trachea    61.925 Larval Carcass    59.925 Adult Head    30 Adult Eye    36.7 Adult Brain    43.2 Adult Thoracic-Abdominal Ganglion    45.2 Adult Crop    51.5 Adult Midgut    42.3 Adult Hindgut    46.6 Adult Malpighian Tubules    38 Adult Fat Body    40.4 Adult Salivary Gland    42.8 Adult Heart    26.375 Adult VirginFemale Spermatheca    48 Adult InseminatedFemale Spermatheca    46.1 Adult Ovary    86.7 Adult Testis    37.4 Adult Male Accessory Gland    70.1 Adult Carcass    40.2 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    117.6 Larval Midgut    37.9 Larval Hindgut    54.8 Larval Malpighian Tubules    75.9 Larval Fat Body    46.4 Larval Salivary Gland    76.5 Larval Trachea    61.925 Larval Carcass    59.925 Adult Head    30 Adult Eye    36.7 Adult Brain    43.2 Adult Thoracic-Abdominal Ganglion    45.2 Adult Crop    51.5 Adult Midgut    42.3 Adult Hindgut    46.6 Adult Malpighian Tubules    38 Adult Fat Body    40.4 Adult Salivary Gland    42.8 Adult Heart    26.375 Adult VirginFemale Spermatheca    48 Adult InseminatedFemale Spermatheca    46.1 Adult Ovary    86.7 Adult Testis    37.4 Adult Male Accessory Gland    70.1 Adult Carcass    40.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    117.6 Larval Midgut    37.9 Larval Hindgut    54.8 Larval Malpighian Tubules    75.9 Larval Fat Body    46.4 Larval Salivary Gland    76.5 Larval Trachea    61.925 Larval Carcass    59.925 Adult Head    30 Adult Eye    36.7 Adult Brain    43.2 Adult Thoracic-Abdominal Ganglion    45.2 Adult Crop    51.5 Adult Midgut    42.3 Adult Hindgut    46.6 Adult Malpighian Tubules    38 Adult Fat Body    40.4 Adult Salivary Gland    42.8 Adult Heart    26.375 Adult VirginFemale Spermatheca    48 Adult InseminatedFemale Spermatheca    46.1 Adult Ovary    86.7 Adult Testis    37.4 Adult Male Accessory Gland    70.1 Adult Carcass    40.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    117.6 Larval Midgut    37.9 Larval Hindgut    54.8 Larval Malpighian Tubules    75.9 Larval Fat Body    46.4 Larval Salivary Gland    76.5 Larval Trachea    61.925 Larval Carcass    59.925 Adult Head    30 Adult Eye    36.7 Adult Brain    43.2 Adult Thoracic-Abdominal Ganglion    45.2 Adult Crop    51.5 Adult Midgut    42.3 Adult Hindgut    46.6 Adult Malpighian Tubules    38 Adult Fat Body    40.4 Adult Salivary Gland    42.8 Adult Heart    26.375 Adult VirginFemale Spermatheca    48 Adult InseminatedFemale Spermatheca    46.1 Adult Ovary    86.7 Adult Testis    37.4 Adult Male Accessory Gland    70.1 Adult Carcass    40.2 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    117.6 Larval Midgut    37.9 Larval Hindgut    54.8 Larval Malpighian Tubules    75.9 Larval Fat Body    46.4 Larval Salivary Gland    76.5 Larval Trachea    61.925 Larval Carcass    59.925 Adult Head    30 Adult Eye    36.7 Adult Brain    43.2 Adult Thoracic-Abdominal Ganglion    45.2 Adult Crop    51.5 Adult Midgut    42.3 Adult Hindgut    46.6 Adult Malpighian Tubules    38 Adult Fat Body    40.4 Adult Salivary Gland    42.8 Adult Heart    26.375 Adult VirginFemale Spermatheca    48 Adult InseminatedFemale Spermatheca    46.1 Adult Ovary    86.7 Adult Testis    37.4 Adult Male Accessory Gland    70.1 Adult Carcass    40.2 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    117.6 Larval Midgut    37.9 Larval Hindgut    54.8 Larval Malpighian Tubules    75.9 Larval Fat Body    46.4 Larval Salivary Gland    76.5 Larval Trachea    61.925 Larval Carcass    59.925 Adult Head    30 Adult Eye    36.7 Adult Brain    43.2 Adult Thoracic-Abdominal Ganglion    45.2 Adult Crop    51.5 Adult Midgut    42.3 Adult Hindgut    46.6 Adult Malpighian Tubules    38 Adult Fat Body    40.4 Adult Salivary Gland    42.8 Adult Heart    26.375 Adult VirginFemale Spermatheca    48 Adult InseminatedFemale Spermatheca    46.1 Adult Ovary    86.7 Adult Testis    37.4 Adult Male Accessory Gland    70.1 Adult Carcass    40.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    117.6 Larval Midgut    37.9 Larval Hindgut    54.8 Larval Malpighian Tubules    75.9 Larval Fat Body    46.4 Larval Salivary Gland    76.5 Larval Trachea    61.925 Larval Carcass    59.925 Adult Head    30 Adult Eye    36.7 Adult Brain    43.2 Adult Thoracic-Abdominal Ganglion    45.2 Adult Crop    51.5 Adult Midgut    42.3 Adult Hindgut    46.6 Adult Malpighian Tubules    38 Adult Fat Body    40.4 Adult Salivary Gland    42.8 Adult Heart    26.375 Adult VirginFemale Spermatheca    48 Adult InseminatedFemale Spermatheca    46.1 Adult Ovary    86.7 Adult Testis    37.4 Adult Male Accessory Gland    70.1 Adult Carcass    40.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    117.6 Larval Midgut    37.9 Larval Hindgut    54.8 Larval Malpighian Tubules    75.9 Larval Fat Body    46.4 Larval Salivary Gland    76.5 Larval Trachea    61.925 Larval Carcass    59.925 Adult Head    30 Adult Eye    36.7 Adult Brain    43.2 Adult Thoracic-Abdominal Ganglion    45.2 Adult Crop    51.5 Adult Midgut    42.3 Adult Hindgut    46.6 Adult Malpighian Tubules    38 Adult Fat Body    40.4 Adult Salivary Gland    42.8 Adult Heart    26.375 Adult VirginFemale Spermatheca    48 Adult InseminatedFemale Spermatheca    46.1 Adult Ovary    86.7 Adult Testis    37.4 Adult Male Accessory Gland    70.1 Adult Carcass    40.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    30   NA  Eye    36.7   NA  Brain    43.2   117.6  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    45.2   NA  Crop    51.5   no informative data  Midgut    no informative data   54.8  Hindgut    46.6   75.9  Malpighian Tubules    38   46.4  Fat Body    no informative data   76.5  Salivary Gland    no informative data   NA  Heart    26.375   61.925  Trachea    NA   NA  VirginFemale Spermatheca    48   NA  InseminatedFemale Spermatheca    46.1   NA  Ovary    86.7   NA  Testis    37.4   NA  Male Accessory Gland    70.1   59.925  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    22 central nervous system, larvae L3    25 central nervous system, pupae P8    9 head, virgin 1-day female    5 head, virgin 4-day female    6 head, virgin 20-day female    7 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    7 head, mated 4-day male    6 head, mated 20-day male    9 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    5 digestive system, 4-day adult    5 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    8 fat body, pupae P8    4 carcass, larvae L3 wandering    16 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    5 ovary, virgin 4-day female    26 ovary, mated 4-day female    23 testis, mated 4-day male    18 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    22 central nervous system, larvae L3    25 central nervous system, pupae P8    9 head, virgin 1-day female    5 head, virgin 4-day female    6 head, virgin 20-day female    7 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    7 head, mated 4-day male    6 head, mated 20-day male    9 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    5 digestive system, 4-day adult    5 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    8 fat body, pupae P8    4 carcass, larvae L3 wandering    16 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    5 ovary, virgin 4-day female  26 ovary, mated 4-day female    23 testis, mated 4-day male    18 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    22 central nervous system, larvae L3    25 central nervous system, pupae P8    9 head, virgin 1-day female    5 head, virgin 4-day female    6 head, virgin 20-day female    7 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    7 head, mated 4-day male    6 head, mated 20-day male    9 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    5 digestive system, 4-day adult    5 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    8 fat body, pupae P8    4 carcass, larvae L3 wandering    16 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    5 ovary, virgin 4-day female    26 ovary, mated 4-day female    23 testis, mated 4-day male    18 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    22 central nervous system, larvae L3    25 central nervous system, pupae P8    9 head, virgin 1-day female    5 head, virgin 4-day female    6 head, virgin 20-day female    7 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    7 head, mated 4-day male    6 head, mated 20-day male    9 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    5 digestive system, 4-day adult    5 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    8 fat body, pupae P8    4 carcass, larvae L3 wandering    16 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    5 ovary, virgin 4-day female    26 ovary, mated 4-day female    23 testis, mated 4-day male    18 accessory gland, mated 4-day male    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    22 central nervous system, larvae L3    25 central nervous system, pupae P8    9 head, virgin 1-day female    5 head, virgin 4-day female    6 head, virgin 20-day female    7 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    7 head, mated 4-day male    6 head, mated 20-day male    9 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    5 digestive system, 4-day adult    5 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    8 fat body, pupae P8    4 carcass, larvae L3 wandering    16 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    5 ovary, virgin 4-day female    26 ovary, mated 4-day female    23 testis, mated 4-day male    18 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    22 central nervous system, larvae L3    25 central nervous system, pupae P8    9 head, virgin 1-day female    5 head, virgin 4-day female    6 head, virgin 20-day female    7 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    7 head, mated 4-day male    6 head, mated 20-day male    9 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    5 digestive system, 4-day adult    5 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    8 fat body, pupae P8    4 carcass, larvae L3 wandering    16 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    5 ovary, virgin 4-day female  26 ovary, mated 4-day female    23 testis, mated 4-day male    18 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    22 central nervous system, larvae L3    25 central nervous system, pupae P8    9 head, virgin 1-day female    5 head, virgin 4-day female    6 head, virgin 20-day female    7 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    7 head, mated 4-day male    6 head, mated 20-day male    9 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    5 digestive system, 4-day adult    5 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    8 fat body, pupae P8    4 carcass, larvae L3 wandering    16 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    5 ovary, virgin 4-day female    26 ovary, mated 4-day female    23 testis, mated 4-day male    18 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    22 central nervous system, larvae L3    25 central nervous system, pupae P8    9 head, virgin 1-day female    5 head, virgin 4-day female    6 head, virgin 20-day female    7 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    7 head, mated 4-day male    6 head, mated 20-day male    9 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    5 digestive system, 4-day adult    5 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    8 fat body, pupae P8    4 carcass, larvae L3 wandering    16 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    5 ovary, virgin 4-day female    26 ovary, mated 4-day female    23 testis, mated 4-day male    18 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    30 embryo 02-04hr    21 embryo 04-06hr    36 embryo 06-08hr    28 embryo 08-10hr    22 embryo 10-12hr    21 embryo 12-14hr    12 embryo 14-16hr    9 embryo 16-18hr    6 embryo 18-20hr    3 embryo 20-22hr    3 embryo 22-24hr    4 larva L1    8 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    16 white prepupae new    15 white prepupae 12hr    21 white prepupae 24hr    22 pupae 2d postWPP    13 pupae 3d postWPP    6 pupae 4d postWPP    7 adult male 01day    10 adult male 05day    12 adult male 30day    12 adult female 01day    13 adult female 05day    17 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (30) embryo 02-04hr    21 embryo 04-06hr  (36) embryo 06-08hr  (28) embryo 08-10hr    22 embryo 10-12hr    21 embryo 12-14hr    12 embryo 14-16hr    9 embryo 16-18hr    6 embryo 18-20hr    3 embryo 20-22hr    3 embryo 22-24hr    4 larva L1    8 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    16 white prepupae new    15 white prepupae 12hr    21 white prepupae 24hr    22 pupae 2d postWPP    13 pupae 3d postWPP    6 pupae 4d postWPP    7 adult male 01day    10 adult male 05day    12 adult male 30day    12 adult female 01day    13 adult female 05day    17 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    30 embryo 02-04hr    21 embryo 04-06hr    36 embryo 06-08hr    28 embryo 08-10hr    22 embryo 10-12hr    21 embryo 12-14hr    12 embryo 14-16hr    9 embryo 16-18hr    6 embryo 18-20hr    3 embryo 20-22hr    3 embryo 22-24hr    4 larva L1    8 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    16 white prepupae new    15 white prepupae 12hr    21 white prepupae 24hr    22 pupae 2d postWPP    13 pupae 3d postWPP    6 pupae 4d postWPP    7 adult male 01day    10 adult male 05day    12 adult male 30day    12 adult female 01day    13 adult female 05day    17 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    30 embryo 02-04hr    21 embryo 04-06hr    36 embryo 06-08hr    28 embryo 08-10hr    22 embryo 10-12hr    21 embryo 12-14hr    12 embryo 14-16hr    9 embryo 16-18hr    6 embryo 18-20hr    3 embryo 20-22hr    3 embryo 22-24hr    4 larva L1    8 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    16 white prepupae new    15 white prepupae 12hr    21 white prepupae 24hr    22 pupae 2d postWPP    13 pupae 3d postWPP    6 pupae 4d postWPP    7 adult male 01day    10 adult male 05day    12 adult male 30day    12 adult female 01day    13 adult female 05day    17 adult female 30day    18 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    30 embryo 02-04hr    21 embryo 04-06hr    36 embryo 06-08hr    28 embryo 08-10hr    22 embryo 10-12hr    21 embryo 12-14hr    12 embryo 14-16hr    9 embryo 16-18hr    6 embryo 18-20hr    3 embryo 20-22hr    3 embryo 22-24hr    4 larva L1    8 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    16 white prepupae new    15 white prepupae 12hr    21 white prepupae 24hr    22 pupae 2d postWPP    13 pupae 3d postWPP    6 pupae 4d postWPP    7 adult male 01day    10 adult male 05day    12 adult male 30day    12 adult female 01day    13 adult female 05day    17 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  30 embryo 02-04hr    21 embryo 04-06hr  (36) embryo 06-08hr  28 embryo 08-10hr    22 embryo 10-12hr    21 embryo 12-14hr    12 embryo 14-16hr    9 embryo 16-18hr    6 embryo 18-20hr    3 embryo 20-22hr    3 embryo 22-24hr    4 larva L1    8 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    16 white prepupae new    15 white prepupae 12hr    21 white prepupae 24hr    22 pupae 2d postWPP    13 pupae 3d postWPP    6 pupae 4d postWPP    7 adult male 01day    10 adult male 05day    12 adult male 30day    12 adult female 01day    13 adult female 05day    17 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    30 embryo 02-04hr    21 embryo 04-06hr    36 embryo 06-08hr    28 embryo 08-10hr    22 embryo 10-12hr    21 embryo 12-14hr    12 embryo 14-16hr    9 embryo 16-18hr    6 embryo 18-20hr    3 embryo 20-22hr    3 embryo 22-24hr    4 larva L1    8 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    16 white prepupae new    15 white prepupae 12hr    21 white prepupae 24hr    22 pupae 2d postWPP    13 pupae 3d postWPP    6 pupae 4d postWPP    7 adult male 01day    10 adult male 05day    12 adult male 30day    12 adult female 01day    13 adult female 05day    17 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    30 embryo 02-04hr    21 embryo 04-06hr    36 embryo 06-08hr    28 embryo 08-10hr    22 embryo 10-12hr    21 embryo 12-14hr    12 embryo 14-16hr    9 embryo 16-18hr    6 embryo 18-20hr    3 embryo 20-22hr    3 embryo 22-24hr    4 larva L1    8 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    16 white prepupae new    15 white prepupae 12hr    21 white prepupae 24hr    22 pupae 2d postWPP    13 pupae 3d postWPP    6 pupae 4d postWPP    7 adult male 01day    10 adult male 05day    12 adult male 30day    12 adult female 01day    13 adult female 05day    17 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    27 embryonic 1182-4H    21 embryonic GM2    25 embryonic Kc167    22 embryonic S1    41 embryonic S3    10 leg disc CME L1    25 wing disc CME-W2    18 wing disc ML-DmD8    24 wing disc ML-DmD9    35 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    31 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    36 eye-antennal disc ML-DmD11    30 antennal disc ML-DmD20-c5    32 mixed discs ML-DmD4-c1    28 CNS ML-DmBG1-c1    24 CNS ML-DmBG2-c2    22 tumorous blood cells mbn2    16 ovary fGS/OSS    27 ovary OSC    18 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  26 Schneider line 2 Sg4  (27) embryonic 1182-4H    21 embryonic GM2    25 embryonic Kc167    22 embryonic S1  (41) embryonic S3    10 leg disc CME L1    25 wing disc CME-W2    18 wing disc ML-DmD8    24 wing disc ML-DmD9  (35) wing disc ML-DmD16-c3    21 wing disc ML-DmD21  (31) wing disc ML-DmD32    23 haltere disc ML-DmD17-c3  (36) eye-antennal disc ML-DmD11  (30) antennal disc ML-DmD20-c5  (32) mixed discs ML-DmD4-c1  (28) CNS ML-DmBG1-c1    24 CNS ML-DmBG2-c2    22 tumorous blood cells mbn2    16 ovary fGS/OSS  (27) ovary OSC    18 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    27 embryonic 1182-4H    21 embryonic GM2    25 embryonic Kc167    22 embryonic S1    41 embryonic S3    10 leg disc CME L1    25 wing disc CME-W2    18 wing disc ML-DmD8    24 wing disc ML-DmD9    35 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    31 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    36 eye-antennal disc ML-DmD11    30 antennal disc ML-DmD20-c5    32 mixed discs ML-DmD4-c1    28 CNS ML-DmBG1-c1    24 CNS ML-DmBG2-c2    22 tumorous blood cells mbn2    16 ovary fGS/OSS    27 ovary OSC    18 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    27 embryonic 1182-4H    21 embryonic GM2    25 embryonic Kc167    22 embryonic S1    41 embryonic S3    10 leg disc CME L1    25 wing disc CME-W2    18 wing disc ML-DmD8    24 wing disc ML-DmD9    35 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    31 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    36 eye-antennal disc ML-DmD11    30 antennal disc ML-DmD20-c5    32 mixed discs ML-DmD4-c1    28 CNS ML-DmBG1-c1    24 CNS ML-DmBG2-c2    22 tumorous blood cells mbn2    16 ovary fGS/OSS    27 ovary OSC    18 ovary OSS    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    27 embryonic 1182-4H    21 embryonic GM2    25 embryonic Kc167    22 embryonic S1    41 embryonic S3    10 leg disc CME L1    25 wing disc CME-W2    18 wing disc ML-DmD8    24 wing disc ML-DmD9    35 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    31 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    36 eye-antennal disc ML-DmD11    30 antennal disc ML-DmD20-c5    32 mixed discs ML-DmD4-c1    28 CNS ML-DmBG1-c1    24 CNS ML-DmBG2-c2    22 tumorous blood cells mbn2    16 ovary fGS/OSS    27 ovary OSC    18 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  26 Schneider line 2 Sg4  27 embryonic 1182-4H    21 embryonic GM2    25 embryonic Kc167    22 embryonic S1  (41) embryonic S3    10 leg disc CME L1    25 wing disc CME-W2    18 wing disc ML-DmD8    24 wing disc ML-DmD9  (35) wing disc ML-DmD16-c3    21 wing disc ML-DmD21  31 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3  (36) eye-antennal disc ML-DmD11  30 antennal disc ML-DmD20-c5  32 mixed discs ML-DmD4-c1  28 CNS ML-DmBG1-c1    24 CNS ML-DmBG2-c2    22 tumorous blood cells mbn2    16 ovary fGS/OSS  27 ovary OSC    18 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    27 embryonic 1182-4H    21 embryonic GM2    25 embryonic Kc167    22 embryonic S1    41 embryonic S3    10 leg disc CME L1    25 wing disc CME-W2    18 wing disc ML-DmD8    24 wing disc ML-DmD9    35 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    31 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    36 eye-antennal disc ML-DmD11    30 antennal disc ML-DmD20-c5    32 mixed discs ML-DmD4-c1    28 CNS ML-DmBG1-c1    24 CNS ML-DmBG2-c2    22 tumorous blood cells mbn2    16 ovary fGS/OSS    27 ovary OSC    18 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    27 embryonic 1182-4H    21 embryonic GM2    25 embryonic Kc167    22 embryonic S1    41 embryonic S3    10 leg disc CME L1    25 wing disc CME-W2    18 wing disc ML-DmD8    24 wing disc ML-DmD9    35 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    31 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    36 eye-antennal disc ML-DmD11    30 antennal disc ML-DmD20-c5    32 mixed discs ML-DmD4-c1    28 CNS ML-DmBG1-c1    24 CNS ML-DmBG2-c2    22 tumorous blood cells mbn2    16 ovary fGS/OSS    27 ovary OSC    18 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    5 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    16 Paraquat 10 mM 48 hrs, 4-day adult    16 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    5 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    16 Paraquat 10 mM 48 hrs, 4-day adult    16 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    5 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    16 Paraquat 10 mM 48 hrs, 4-day adult    16 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    5 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    16 Paraquat 10 mM 48 hrs, 4-day adult    16 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    5 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    16 Paraquat 10 mM 48 hrs, 4-day adult    16 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    5 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    16 Paraquat 10 mM 48 hrs, 4-day adult    16 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    5 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    16 Paraquat 10 mM 48 hrs, 4-day adult    16 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    5 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    16 Paraquat 10 mM 48 hrs, 4-day adult    16 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_06 mE1_20_mRNA_expression_cluster_04
External Data & Images
Linkouts	BDGP expression data • SD10038 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0038578 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7957-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for MED17 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele cell lethal | somatic clone MED17s2956 lethal MED17GD4153 lethal, with Scer\GAL4pnr-MD237 MED17GD4153 lethal | recessive MED17s2956 Phenotype manifest in Allele embryonic/larval brain | larval stage MED17GD4153
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of MED17 Class Mutagen Stocks Known lesion MED17s2956 P-element activity 1 -- MED17s9256 0 --
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of MED17 Class Mutagen Stocks Known lesion MED17GD4153 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes MED17HMS01141 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes MED17KK105730 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes MED17a.cKa in vitro construct - RNAi 0 Yes MED17cKa in vitro construct - RNAi 0 Yes MED17dsRNA.cGa in vitro construct - RNAi 0 Yes MED17NIG.7957R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)BSC650 (Christensen et al., 2008.10.20) Df(3R)Exel6178 (Ryder, 2004.4.26) Df(3R)P14 (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4153} NA P{KK105730} NA P{NIG.7957R} NA P{TRiP.HMS01141} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}MED17s2956 No
Gene Ontology: Function, Process & Cellular Component ( 12 unique terms )
Terms Based on Experimental Evidence ( 11 terms )
Molecular Function
CV term Evidence References
activating transcription factor binding inferred from physical interaction with Dif (Park et al., 2003) inferred from physical interaction with Hsf (Park et al., 2003) RNA polymerase II transcription cofactor activity inferred from mutant phenotype (assigned by UniProtKB) (Park et al., 2001) contributes_to transcription coactivator activity inferred from direct assay (Gu et al., 2002)
Biological Process
CV term Evidence References
cellular process inferred from mutant phenotype (Boube et al., 2000) mitotic G2 DNA damage checkpoint inferred from genetic interaction with nbs (Kondo and Perrimon, 2011) positive regulation of transcription from RNA polymerase II promoter inferred from mutant phenotype (Park et al., 2003) regulation of transcription from RNA polymerase II promoter inferred from direct assay (Gu et al., 2002) sex comb development inferred from genetic interaction with Scr (Boube et al., 2000) transcription from RNA polymerase II promoter inferred from mutant phenotype (assigned by UniProtKB) (Park et al., 2001)
Cellular Component
CV term Evidence References
mediator complex inferred from direct assay (Gu et al., 2002) inferred from direct assay (assigned by UniProtKB) (Park et al., 2001) nucleus inferred from direct assay (Gu et al., 2002, Park et al., 2003)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
RNA polymerase II transcription cofactor activity inferred from sequence or structural similarity with EMBL:AF055994 (FlyBase, 1992-) inferred from sequence or structural similarity with human CRSP6 (Boube et al., 2000)
Biological Process
CV term Evidence References
transcription from RNA polymerase II promoter inferred from sequence or structural similarity with EMBL:AF055994 (FlyBase, 1992-) transcription initiation from RNA polymerase II promoter inferred from sequence or structural similarity with human CRSP6 (Boube et al., 2000)
Cellular Component
CV term Evidence References
mediator complex inferred from sequence or structural similarity with EMBL:AF055994 (FlyBase, 1992-) inferred from sequence or structural similarity with human CRSP6 (Boube et al., 2000) nucleus inferred from sequence or structural similarity with EMBL:AF055994 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
MED17 - Bap60 experimental knowledge based (Guruharsha et al., 2011) MED17 - CG11505 experimental knowledge based (Guruharsha et al., 2011) MED17 - CG12493 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) MED17 - CG14036 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) MED17 - CG14480 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) MED17 - CG1532 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) MED17 - CG15625 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) MED17 - CG17002 experimental knowledge based (Guruharsha et al., 2011) MED17 - CG2017 experimental knowledge based (Guruharsha et al., 2011) MED17 - CG2199 experimental knowledge based (Guruharsha et al., 2011) MED17 - CG3008 experimental knowledge based (Guruharsha et al., 2011) MED17 - CG30491 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) MED17 - CG32479 experimental knowledge based (Guruharsha et al., 2011) MED17 - CG34159 experimental knowledge based (Guruharsha et al., 2011) MED17 - CG5623 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) MED17 - CG7049 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) MED17 - CG7185 experimental knowledge based (Guruharsha et al., 2011) MED17 - CG7542 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) MED17 - Ccs anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) MED17 - Cdk8 experimental knowledge based (Guruharsha et al., 2011) MED17 - Der-2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) MED17 - MED10 experimental knowledge based (Guruharsha et al., 2011) MED17 - MED11 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) MED17 - MED14 experimental knowledge based (Guruharsha et al., 2011) MED17 - MED15 experimental knowledge based (Guruharsha et al., 2011) MED17 - MED16 experimental knowledge based (Guruharsha et al., 2011) MED17 - MED18 experimental knowledge based (Guruharsha et al., 2011) MED17 - MED20 experimental knowledge based (Guruharsha et al., 2011) MED17 - MED22 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) MED17 - MED23 experimental knowledge based (Guruharsha et al., 2011) MED17 - MED24 experimental knowledge based (Guruharsha et al., 2011) MED17 - MED25 experimental knowledge based (Guruharsha et al., 2011) MED17 - MED27 experimental knowledge based (Guruharsha et al., 2011) MED17 - MED30 experimental knowledge based (Guruharsha et al., 2011) MED17 - MED31 experimental knowledge based (Guruharsha et al., 2011) MED17 - MED4 experimental knowledge based (Guruharsha et al., 2011) MED17 - MED6 experimental knowledge based (Guruharsha et al., 2011) MED17 - MED7 experimental knowledge based (Guruharsha et al., 2011) MED17 - MED8 experimental knowledge based (Guruharsha et al., 2011) MED17 - Pa1 experimental knowledge based (Guruharsha et al., 2011) MED17 - Psi experimental knowledge based (Guruharsha et al., 2011) MED17 - RpS12 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) MED17 - RpS21 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) MED17 - Rrp45 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) MED17 - Sec23 experimental knowledge based (Guruharsha et al., 2011) MED17 - Snr1 experimental knowledge based (Guruharsha et al., 2011) MED17 - Ssdp experimental knowledge based (Guruharsha et al., 2011) MED17 - alrm anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) MED17 - boca experimental knowledge based (Guruharsha et al., 2011) MED17 - brm experimental knowledge based (Guruharsha et al., 2011) MED17 - dsh experimental knowledge based (Guruharsha et al., 2011) MED17 - ebi experimental knowledge based (Guruharsha et al., 2011) MED17 - enc experimental knowledge based (Guruharsha et al., 2011) MED17 - fan anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) MED17 - fh anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) MED17 - ix experimental knowledge based (Guruharsha et al., 2011) MED17 - mor experimental knowledge based (Guruharsha et al., 2011) MED17 - osa experimental knowledge based (Guruharsha et al., 2011) MED17 - ptip experimental knowledge based (Guruharsha et al., 2011) MED17 - sec24 experimental knowledge based (Guruharsha et al., 2011) MED17 - skd experimental knowledge based (Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions MED17 allele Gene References MED17s2956 pb (Boube et al., 2000) Scr (Boube et al., 2000) skd (Boube et al., 2000) unspecified skd (Faucher et al., 2000)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67196 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0038578 DroID - A comprehensive database of gene and protein interactions. • FBgn0038578 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42175
Orthologs
OrthoDB Orthologs (41) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG69CQT6 Dipteran inclusive ortholog search EOG6CRM78 Insect inclusive ortholog search EOG6GMSS1 Arthropod inclusive ortholog search EOG6D254W Metazoa inclusive ortholog search EOG625JKP
Orthologs in Drosophila Species (EOG69CQT6)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\MED17     Drosophila simulans   Dsim\GD19210 Y   Drosophila sechellia   Dsec\GM15283 Y   Drosophila erecta   Dere\GG22704 Y   Drosophila yakuba   Dyak\GE25518 Y   Drosophila ananassae   Dana\GF18510 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA20720 Y   Drosophila persimilis   Dper\GL12596 Y   Drosophila willistoni   Dwil\GK11248 Y   Drosophila virilis   Dvir\GJ23280 Y   Drosophila mojavensis   Dmoj\GI23722 Y   Drosophila grimshawi   Dgri\GH15742 Y
Orthologs in non-Drosophila Dipterans (EOG6CRM78)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\MED17   Anopheles gambiae Malaria mosquito  Agam\MED17   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ000780
Orthologs in non-Dipteran Insects (EOG6GMSS1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\MED17   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG011400   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH15902   Atta cephalotes Leafcutter ant  Acep\ACEP10956   Camponotus floridanus Florida carpenter ant  Cflo\CFLO19677   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL22384   Linepithema humile Argentine ant  Lhum\LH23568   Pogonomyrmex barbatus Red harvester ant  Pbar\PB24237   Solenopsis invicta Red fire ant  Sinv\SINV19219   Solenopsis invicta Red fire ant  Sinv\SINV12130   Acyrthosiphon pisum Pea aphid  Apim\ACYPI008931   Bombyx mori Silkmoth  Bmor\BGIBMGA005197   Pediculus humanus Human body louse  Phum\PHUM350940   Tribolium castaneum Red flour beetle  Tcas\GLEAN_07640
Orthologs in non-Insect Arthropods (EOG6D254W)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\nme2   Ixodes scapularis Deer tick  Isca\ISCW007804   Ixodes scapularis Deer tick  Isca\ISCW024257
Orthologs in non-Arthropod Metazoa (EOG625JKP)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\mdt-17   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_024720gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_024927gn   Danio rerio Zebrafish  Drer\ENSDARG00000006345   Xenopus tropicalis Western clawed frog  Xtro\med17   Gallus gallus Domestic chicken  Ggal\MED17   Mus musculus House mouse  Mmus\Med17   Rattus norvegicus Norway rat  Rnor\Med17   Homo sapiens Human  Hsap\MED17
Human Orthologs (1)
Gene OMIM HGNC Hsap\MED17
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD19210 Drosophila sechellia Dsec\GM15283 Drosophila erecta Dere\GG22704 Drosophila yakuba Dyak\GE25518 Drosophila ananassae Dana\GF18510 Drosophila pseudoobscura pseudoobscura Dpse\GA20720 Drosophila persimilis Dper\GL12596 Drosophila willistoni Dwil\GK11248 Drosophila virilis Dvir\GJ23280 Drosophila mojavensis Dmoj\GI23722 Drosophila grimshawi Dgri\GH15742
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	34664 y1 sc* v1; P{TRiP.HMS01141}attP2 10307 w1118; P{lacW}MED17s2956/TM3, Sb1
VDRC	v105264 P{KK105730}VIE-260B v44027 w1118; P{GD4153}v44027 v44024 w1118; P{GD4153}v44024/CyO
Genomic Clones ( 2 )
	BACR03J17 BACR27G04 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 33 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	SD10038
Other clones	DPiM_SD10038
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT23333 AT27336 GM32185 RH27027 RH32802 RH51417 RH55851
Other clones	33732 69513 70632 214345.56 CK01.57B.B10 CK00124 EC00423 EK046539 EK046543 EK146625 EP18958 RP004113673 RP004151376 RP004180897 RP004193025 RP004219466 RP004227344 RP004228812 RP004247719 RP004255052 RP004258373 RP004269646 RP004338046 RP004488851
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0038578 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42175
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: MED17 Trap80 (Bourbon et al., 2004)
Source for database merge of	Source for merge of: Trap80 CG7957 (FlyBase, 1996-) Source for merge of: Trap80 l(3)s2956 (Bourbon, 2000.3.3)
Additional comments	Source for merge of Trap80 CG7957 was sequence comparison (date:000414). (FlyBase, 1996-)
Other Comments
	dsRNA has been made from templates generated with primers directed against this gene. (Marr et al., 2006) MED17 is required for cell viability. (Boube et al., 2000) Mutations in MED17 enhance distal sex comb teeth in the T1 leg. Labial structures are lost and replaced with leg-specific cell identities in the labium. (Faucher et al., 2000)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_142429 RefSeq (Proteins) • NP_650686 DDBJ / EMBL / GenBank • AA142021 AA142023 AAF55506 AAF63336 AAG02460 AAM50031 AF244916 AF289995 AI543317 AQ026391 AW944616 AY118662 Entrez Gene - A searchable database of RefSeq genes. • 42175 UniProtKB/Swiss-Prot • Q9VEC1
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Mediator complex, subunit Med17 (IPR019313) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • SD10038
Linkouts
	BioGRID - A database of protein and genetic interactions • 67196 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0038578 DroID - A comprehensive database of gene and protein interactions. • FBgn0038578 DRSC - Results from RNAi screens. • FBgn0038578 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0038578 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7957-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0038578 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42175 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42175 modMine - Data generated by the modENCODE project. • FBgn0038578
Synonyms & Secondary IDs ( 12 )
Reported As
Symbol Synonym	CG7957 (Keleman et al., 2009.8.5, Ni et al., 2010.12.1) dTRAP80 (Gu et al., 2002, Park et al., 2003, Gim et al., 2001) dTrap80 (Faucher et al., 2000) dTRAP80/SRB4 (Bourbon et al., 2001) l(3)s2956 (Boube et al., 2000, Spradling et al., 1999, BDGP Project Members, 1994-1999, ) Med17 (Kim et al., 2004, Kim and Lis, 2005, Wang et al., 2008, Hsu et al., 2008, Martin et al., 2007) MED17 (Marr et al., 2006, Kim and Lis, 2005, Christensen et al., 2008.10.20, Toku et al., 2011, Chicoine et al., 2007, Bosveld et al., 2008, Kondo and Perrimon, 2011, Wasbrough et al., 2010, Neumüller et al., 2011, Japanese National Institute of Genetics, 2012.5.21) p70 (Park et al., 2001) Trap80 (Armstrong et al., 2005, Bourbon et al., 2004, Gutierrez et al., 2003, FlyBase, 1996-, Bourbon, 2000.3.3, Kim and Lis, 2005, Guglielmi et al., 2004) TRAP80 (Boube et al., 2002)
Name Synonym	Mediator (Park et al., 2001) Mediator complex subunit 17 (Bourbon et al., 2004, Davis et al., 2011)
Secondary FlyBase IDs
	FBgn0011035
References ( 50 )
Generate a list of	All references relating to this gene ( 50 )
List References by type	Research paper  ( 22 ) Supplementary material  ( 7 ) Review  ( 2 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 2 ) FlyBase analysis  ( 2 ) Letter  ( 1 ) Stock list  ( 1 ) DNA/RNA sequence record  ( 2 ) Website  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 5 )
	Baradaran-Heravi et al., 2012, Hum. Mol. Genet. 21(11): 2572--2587 Penetrance of biallelic SMARCAL1 mutations is associated with environmental and genetic disturbances of gene expression. [FBrf0218299] Davis et al., 2011, BMC Dev. Biol. 11: 66 Identification of common and cell type specific LXXLL motif EcR cofactors using a bioinformatics refined candidate RNAi screen in Drosophila melanogaster cell lines. [FBrf0216830] Kondo and Perrimon, 2011, Sci. Signal. 4(154): rs1 A Genome-Wide RNAi Screen Identifies Core Components of the G2-M DNA Damage Checkpoint. [FBrf0212700] Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621] Toku et al., 2011, Comput. Biol. Chem. 35(5): 282--292 Reconstruction and crosstalk of protein-protein interaction networks of Wnt and Hedgehog signaling in Drosophila melanogaster. [FBrf0216393] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...