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Gene Dmel\CG7708

General Information
Symbol	Dmel\CG7708	Species	D. melanogaster
Name		Annotation symbol	CG7708
Feature type	protein_coding_gene	FlyBase ID	FBgn0038641
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	91C1-91C1	Sequence location	3R:14,506,328..14,511,029 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG7708 (FBgn0038641). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: amino acid transmembrane transporter activity; proline:sodium symporter activity; choline transmembrane transporter activity. Based on sequence similarity, it is predicted to be involved in the biological process: acetylcholine biosynthetic process; amino acid transmembrane transport. 3 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Sodium/solute symporter. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 12-24 hour embryonic stages, during early larval stages, during late pupal stages, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval central nervous system. Comments on Affy2 ProbeSet: ProbeSet 1624129_s_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of CG7708. Gene sequence location is 3R:14506328..14511029.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 91C1-91C1   Limits computationally determined from genome sequence between P{PZ}sprd05284 and P{PZ}cdi07013&P{lacW}nosj3B6
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG7708 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG7708-RA FBtr0083668  NM_142486   3314   614 CG7708-RB FBtr0083669  NM_169832   3793   614
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG7708-PA   FBpp0083083   66.9   614   5.05     NP_650743   AAF55583 CG7708-PB   FBpp0083084   66.9   614   5.05     NP_732369   AAN13786
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Sodium/solute symporter (IPR001734)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF55583   AE014297 AAN13786   AI061857   AW940114   AY047521 AAK77253   BI240034   BI358034   BI565753   BI592423   BI608211   BI608352   BI609977   BI622886   BI629504   BI630566   BT030144   CK135728   CO270262   CO281085   CO290514   CO308186   EC058899   EC061669   EC082255   EC203733
UniProtKB/Swiss-Prot	Q9VE46
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 13 -- 16   embryonic antennal sense organ   (Fisher et al., 2012) embryonic brain   (Fisher et al., 2012) embryonic head sensory system   (Fisher et al., 2012) embryonic maxillary sensory complex   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) northern blot Stage Tissue/Position (including subcellular localization) Reference adult stage   adult head   (Romero-Calderon et al., 2007)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval central nervous system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    457.725 Larval Midgut    5.6 Larval Hindgut    4.4 Larval Malpighian Tubules    2.9 Larval Fat Body    3.8 Larval Salivary Gland    2.4 Larval Trachea    3.125 Larval Carcass    7.3 Adult Head    209.4 Adult Eye    89.375 Adult Brain    1331.5 Adult Thoracic-Abdominal Ganglion    1225.5 Adult Crop    4 Adult Midgut    1.2 Adult Hindgut    2.7 Adult Malpighian Tubules    2.7 Adult Fat Body    13.2 Adult Salivary Gland    6.5 Adult Heart    3.55 Adult VirginFemale Spermatheca    18.9 Adult InseminatedFemale Spermatheca    23.6 Adult Ovary    0.9 Adult Testis    2 Adult Male Accessory Gland    3.3 Adult Carcass    25.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    457.725 Larval Midgut    5.6 Larval Hindgut    4.4 Larval Malpighian Tubules    2.9 Larval Fat Body    3.8 Larval Salivary Gland    2.4 Larval Trachea    3.125 Larval Carcass    7.3 Adult Head    209.4 Adult Eye    89.375 Adult Brain  (1331.5) Adult Thoracic-Abdominal Ganglion  (1225.5) Adult Crop    4 Adult Midgut    1.2 Adult Hindgut    2.7 Adult Malpighian Tubules    2.7 Adult Fat Body    13.2 Adult Salivary Gland    6.5 Adult Heart    3.55 Adult VirginFemale Spermatheca    18.9 Adult InseminatedFemale Spermatheca    23.6 Adult Ovary    0.9 Adult Testis    2 Adult Male Accessory Gland    3.3 Adult Carcass    25.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    457.725 Larval Midgut    5.6 Larval Hindgut    4.4 Larval Malpighian Tubules    2.9 Larval Fat Body    3.8 Larval Salivary Gland    2.4 Larval Trachea    3.125 Larval Carcass    7.3 Adult Head    209.4 Adult Eye    89.375 Adult Brain  (1331.5) Adult Thoracic-Abdominal Ganglion  (1225.5) Adult Crop    4 Adult Midgut    1.2 Adult Hindgut    2.7 Adult Malpighian Tubules    2.7 Adult Fat Body    13.2 Adult Salivary Gland    6.5 Adult Heart    3.55 Adult VirginFemale Spermatheca    18.9 Adult InseminatedFemale Spermatheca    23.6 Adult Ovary    0.9 Adult Testis    2 Adult Male Accessory Gland    3.3 Adult Carcass    25.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    457.725 Larval Midgut    5.6 Larval Hindgut    4.4 Larval Malpighian Tubules    2.9 Larval Fat Body    3.8 Larval Salivary Gland    2.4 Larval Trachea    3.125 Larval Carcass    7.3 Adult Head    209.4 Adult Eye    89.375 Adult Brain    1331.5 Adult Thoracic-Abdominal Ganglion    1225.5 Adult Crop    4 Adult Midgut    1.2 Adult Hindgut    2.7 Adult Malpighian Tubules    2.7 Adult Fat Body    13.2 Adult Salivary Gland    6.5 Adult Heart    3.55 Adult VirginFemale Spermatheca    18.9 Adult InseminatedFemale Spermatheca    23.6 Adult Ovary    0.9 Adult Testis    2 Adult Male Accessory Gland    3.3 Adult Carcass    25.2 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    457.725 Larval Midgut    5.6 Larval Hindgut    4.4 Larval Malpighian Tubules    2.9 Larval Fat Body    3.8 Larval Salivary Gland    2.4 Larval Trachea    3.125 Larval Carcass    7.3 Adult Head    209.4 Adult Eye    89.375 Adult Brain    1331.5 Adult Thoracic-Abdominal Ganglion    1225.5 Adult Crop    4 Adult Midgut    1.2 Adult Hindgut    2.7 Adult Malpighian Tubules    2.7 Adult Fat Body    13.2 Adult Salivary Gland    6.5 Adult Heart    3.55 Adult VirginFemale Spermatheca    18.9 Adult InseminatedFemale Spermatheca    23.6 Adult Ovary    0.9 Adult Testis    2 Adult Male Accessory Gland    3.3 Adult Carcass    25.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    457.725 Larval Midgut    5.6 Larval Hindgut    4.4 Larval Malpighian Tubules    2.9 Larval Fat Body    3.8 Larval Salivary Gland    2.4 Larval Trachea    3.125 Larval Carcass    7.3 Adult Head    209.4 Adult Eye    89.375 Adult Brain  (1331.5) Adult Thoracic-Abdominal Ganglion  (1225.5) Adult Crop    4 Adult Midgut    1.2 Adult Hindgut    2.7 Adult Malpighian Tubules    2.7 Adult Fat Body    13.2 Adult Salivary Gland    6.5 Adult Heart    3.55 Adult VirginFemale Spermatheca    18.9 Adult InseminatedFemale Spermatheca    23.6 Adult Ovary    0.9 Adult Testis    2 Adult Male Accessory Gland    3.3 Adult Carcass    25.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    457.725 Larval Midgut    5.6 Larval Hindgut    4.4 Larval Malpighian Tubules    2.9 Larval Fat Body    3.8 Larval Salivary Gland    2.4 Larval Trachea    3.125 Larval Carcass    7.3 Adult Head    209.4 Adult Eye    89.375 Adult Brain  1331.5 Adult Thoracic-Abdominal Ganglion  1225.5 Adult Crop    4 Adult Midgut    1.2 Adult Hindgut    2.7 Adult Malpighian Tubules    2.7 Adult Fat Body    13.2 Adult Salivary Gland    6.5 Adult Heart    3.55 Adult VirginFemale Spermatheca    18.9 Adult InseminatedFemale Spermatheca    23.6 Adult Ovary    0.9 Adult Testis    2 Adult Male Accessory Gland    3.3 Adult Carcass    25.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    457.725 Larval Midgut    5.6 Larval Hindgut    4.4 Larval Malpighian Tubules    2.9 Larval Fat Body    3.8 Larval Salivary Gland    2.4 Larval Trachea    3.125 Larval Carcass    7.3 Adult Head    209.4 Adult Eye    89.375 Adult Brain    1331.5 Adult Thoracic-Abdominal Ganglion    1225.5 Adult Crop    4 Adult Midgut    1.2 Adult Hindgut    2.7 Adult Malpighian Tubules    2.7 Adult Fat Body    13.2 Adult Salivary Gland    6.5 Adult Heart    3.55 Adult VirginFemale Spermatheca    18.9 Adult InseminatedFemale Spermatheca    23.6 Adult Ovary    0.9 Adult Testis    2 Adult Male Accessory Gland    3.3 Adult Carcass    25.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    209.4   NA  Eye    89.375   NA  Brain    1331.5   457.725  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1225.5   NA  Crop    4   5.6  Midgut    1.2   4.4  Hindgut    2.7   2.9  Malpighian Tubules    2.7   3.8  Fat Body    no informative data   2.4  Salivary Gland    6.5   NA  Heart    3.55   3.125  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    0.9   NA  Testis    2   NA  Male Accessory Gland    3.3   7.3  Carcass    25.2 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    3 central nervous system, pupae P8    7 head, virgin 1-day female    8 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    6 head, mated 4-day female    7 head, mated 20-day female    4 head, mated 1-day male    14 head, mated 4-day male    13 head, mated 20-day male    13 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    3 central nervous system, pupae P8    7 head, virgin 1-day female    8 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    6 head, mated 4-day female    7 head, mated 20-day female    4 head, mated 1-day male    14 head, mated 4-day male    13 head, mated 20-day male    13 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    3 central nervous system, pupae P8    7 head, virgin 1-day female    8 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    6 head, mated 4-day female    7 head, mated 20-day female    4 head, mated 1-day male    14 head, mated 4-day male    13 head, mated 20-day male    13 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    3 central nervous system, pupae P8    7 head, virgin 1-day female    8 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    6 head, mated 4-day female    7 head, mated 20-day female    4 head, mated 1-day male    14 head, mated 4-day male    13 head, mated 20-day male    13 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    3 central nervous system, pupae P8    7 head, virgin 1-day female    8 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    6 head, mated 4-day female    7 head, mated 20-day female    4 head, mated 1-day male    14 head, mated 4-day male    13 head, mated 20-day male    13 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    3 central nervous system, pupae P8    7 head, virgin 1-day female    8 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    6 head, mated 4-day female    7 head, mated 20-day female    4 head, mated 1-day male    14 head, mated 4-day male    13 head, mated 20-day male    13 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    3 central nervous system, pupae P8    7 head, virgin 1-day female    8 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    6 head, mated 4-day female    7 head, mated 20-day female    4 head, mated 1-day male    14 head, mated 4-day male    13 head, mated 20-day male    13 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    3 central nervous system, pupae P8    7 head, virgin 1-day female    8 head, virgin 4-day female    6 head, virgin 20-day female    6 head, mated 1-day female    6 head, mated 4-day female    7 head, mated 20-day female    4 head, mated 1-day male    14 head, mated 4-day male    13 head, mated 20-day male    13 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 12-24 hour embryonic stages, during early larval stages, during late pupal stages, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    6 embryo 16-18hr    12 embryo 18-20hr    14 embryo 20-22hr    14 embryo 22-24hr    14 larva L1    18 larva L2    6 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    2 pupae 2d postWPP    3 pupae 3d postWPP    8 pupae 4d postWPP    11 adult male 01day    6 adult male 05day    6 adult male 30day    7 adult female 01day    4 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    6 embryo 16-18hr    12 embryo 18-20hr    14 embryo 20-22hr    14 embryo 22-24hr    14 larva L1    18 larva L2    6 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    2 pupae 2d postWPP    3 pupae 3d postWPP    8 pupae 4d postWPP    11 adult male 01day    6 adult male 05day    6 adult male 30day    7 adult female 01day    4 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    6 embryo 16-18hr    12 embryo 18-20hr    14 embryo 20-22hr    14 embryo 22-24hr    14 larva L1    18 larva L2    6 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    2 pupae 2d postWPP    3 pupae 3d postWPP    8 pupae 4d postWPP    11 adult male 01day    6 adult male 05day    6 adult male 30day    7 adult female 01day    4 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    6 embryo 16-18hr    12 embryo 18-20hr    14 embryo 20-22hr    14 embryo 22-24hr    14 larva L1    18 larva L2    6 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    2 pupae 2d postWPP    3 pupae 3d postWPP    8 pupae 4d postWPP    11 adult male 01day    6 adult male 05day    6 adult male 30day    7 adult female 01day    4 adult female 05day    1 adult female 30day    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    6 embryo 16-18hr    12 embryo 18-20hr    14 embryo 20-22hr    14 embryo 22-24hr    14 larva L1    18 larva L2    6 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    2 pupae 2d postWPP    3 pupae 3d postWPP    8 pupae 4d postWPP    11 adult male 01day    6 adult male 05day    6 adult male 30day    7 adult female 01day    4 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    6 embryo 16-18hr    12 embryo 18-20hr    14 embryo 20-22hr    14 embryo 22-24hr    14 larva L1    18 larva L2    6 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    2 pupae 2d postWPP    3 pupae 3d postWPP    8 pupae 4d postWPP    11 adult male 01day    6 adult male 05day    6 adult male 30day    7 adult female 01day    4 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    6 embryo 16-18hr    12 embryo 18-20hr    14 embryo 20-22hr    14 embryo 22-24hr    14 larva L1    18 larva L2    6 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    2 pupae 2d postWPP    3 pupae 3d postWPP    8 pupae 4d postWPP    11 adult male 01day    6 adult male 05day    6 adult male 30day    7 adult female 01day    4 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    6 embryo 16-18hr    12 embryo 18-20hr    14 embryo 20-22hr    14 embryo 22-24hr    14 larva L1    18 larva L2    6 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    2 pupae 2d postWPP    3 pupae 3d postWPP    8 pupae 4d postWPP    11 adult male 01day    6 adult male 05day    6 adult male 30day    7 adult female 01day    4 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_14 mE1_20_mRNA_expression_cluster_11
External Data & Images
Linkouts	BDGP expression data • GH02984 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0038641 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7708-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for CG7708 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG7708GD3648 Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of CG7708 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG7708 Class Mutagen Stocks Known lesion CG7708GD3648 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG7708JF03028 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG7708KK109385 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6180 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD3648} NA P{KK109385} NA P{TRiP.JF03028} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
amino acid transmembrane transporter activity inferred from sequence or structural similarity with Eaat1 (Romero-Calderon et al., 2007) choline transmembrane transporter activity inferred from sequence or structural similarity with UniProtKB:Q9GZV3 (assigned by UniProtKB) (Swiss-Prot Project Members, 2005.1.25) proline:sodium symporter activity inferred from sequence or structural similarity with NCBI_gi:445299 (FlyBase, 1992-)
Biological Process
CV term Evidence References
acetylcholine biosynthetic process inferred from sequence or structural similarity with UniProtKB:Q9GZV3 (assigned by UniProtKB) (Swiss-Prot Project Members, 2005.1.25) amino acid transmembrane transport inferred from sequence or structural similarity with Eaat1 (Romero-Calderon et al., 2007)
Cellular Component
CV term Evidence References
integral to membrane inferred from sequence or structural similarity with UniProtKB:Q9GZV3 (assigned by UniProtKB) (Swiss-Prot Project Members, 2005.1.25)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG7708 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0038641
Orthologs
OrthoDB Orthologs (52) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6MCXJX Dipteran inclusive ortholog search EOG6J11HB Insect inclusive ortholog search EOG6G1KBK Arthropod inclusive ortholog search EOG6547DS Metazoa inclusive ortholog search EOG62C92P
Orthologs in Drosophila Species (EOG6MCXJX)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG7708     Drosophila simulans   Dsim\GD19244 Y   Drosophila sechellia   Dsec\GM17885 Y   Drosophila erecta   Dere\GG23047 Y   Drosophila yakuba   Dyak\GE25555 Y   Drosophila ananassae   Dana\GF17121 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA20532 Y   Drosophila persimilis   Dper\GL24427 Y   Drosophila willistoni   Dwil\GK13737 Y   Drosophila virilis   Dvir\GJ14405 Y   Drosophila mojavensis   Dmoj\GI10807 Y   Drosophila grimshawi   Dgri\GH18618 Y
Orthologs in non-Drosophila Dipterans (EOG6J11HB)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL008432   Anopheles gambiae Malaria mosquito  Agam\AGAP002366   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ001604
Orthologs in non-Dipteran Insects (EOG6G1KBK)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB43293   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG013914   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH18211   Atta cephalotes Leafcutter ant  Acep\ACEP19531   Camponotus floridanus Florida carpenter ant  Cflo\CFLO16372   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL16276   Linepithema humile Argentine ant  Lhum\LH18373   Linepithema humile Argentine ant  Lhum\LH18371   Pogonomyrmex barbatus Red harvester ant  Pbar\PB18940   Solenopsis invicta Red fire ant  Sinv\SINV14629   Acyrthosiphon pisum Pea aphid  Apim\ACYPI009916   Bombyx mori Silkmoth  Bmor\BGIBMGA013465   Pediculus humanus Human body louse  Phum\PHUM569780   Tribolium castaneum Red flour beetle  Tcas\TC000935
Orthologs in non-Insect Arthropods (EOG6547DS)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\rbcL   Ixodes scapularis Deer tick  Isca\ISCW012781   Ixodes scapularis Deer tick  Isca\ISCW017788
Orthologs in non-Arthropod Metazoa (EOG62C92P)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\cho-1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_020026gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_016860gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_027877gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_008646gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_009628gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_023541gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_028367gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_004025gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_022796gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_002911gn   Danio rerio Zebrafish  Drer\si:dkey-24h22.4   Danio rerio Zebrafish  Drer\ENSDARG00000060912   Xenopus tropicalis Western clawed frog  Xtro\slc5a7   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000017116   Gallus gallus Domestic chicken  Ggal\LOC428094   Gallus gallus Domestic chicken  Ggal\SLC5A7   Mus musculus House mouse  Mmus\Slc5a7   Rattus norvegicus Norway rat  Rnor\Slc5a7   Homo sapiens Human  Hsap\SLC5A7
Human Orthologs (1)
Gene OMIM HGNC Hsap\SLC5A7
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD19244 Drosophila sechellia Dsec\GM17885 Drosophila erecta Dere\GG23047 Drosophila yakuba Dyak\GE25555 Drosophila ananassae Dana\GF17121 Drosophila pseudoobscura pseudoobscura Dpse\GA20532 Drosophila persimilis Dper\GL24427 Drosophila willistoni Dwil\GK13737 Drosophila virilis Dvir\GJ14405 Drosophila mojavensis Dmoj\GI10807 Drosophila grimshawi Dgri\GH18618
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	28613 y1 v1; P{TRiP.JF03028}attP2
VDRC	v101485 P{KK109385}VIE-260B v30301 w1118; P{GD3648}v30301 v30302 w1118; P{GD3648}v30302
Genomic Clones ( 2 )
	BACR01D01 BACR01F15 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 20 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH02984
Other clones	IP17595
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE36677 RE44695 RH10105 RH12401 RH12763 RH14837 RH54921 RH58381 RH59836
Other clones	37723 153521 CK01.95C.D9 CK01.108D.D1 EK074215 EK098113 EK155939 EK256938 RH63567
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0038641 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42245
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_142486 NM_169832 RefSeq (Proteins) • NP_650743 NP_732369 DDBJ / EMBL / GenBank • AAF55583 AAK77253 AAN13786 AI061857 AW940114 AY047521 BI565753 Entrez Gene - A searchable database of RefSeq genes. • 42245 UniProtKB/Swiss-Prot • Q9VE46
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Sodium/solute symporter (IPR001734) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH02984
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0038641 DRSC - Results from RNAi screens. • FBgn0038641 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0038641 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7708-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0038641 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42245 modMine - Data generated by the modENCODE project. • FBgn0038641
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG7708 (Romero-Calderon et al., 2007, Keleman et al., 2009.8.5, Perkins et al., 2009, Haussmann et al., 2008)
Name Synonym
Secondary FlyBase IDs
References ( 19 )
Research paper	Haussmann et al., 2008, Genome Biol. 9(4): R73 Erect wing regulates synaptic growth in Drosophila by integration of multiple signaling pathways. [FBrf0209726] Romero-Calderon et al., 2007, Dev. Neurobiol. 67(5): 550--569 A screen for neurotransmitter transporters expressed in the visual system of Drosophila melanogaster identifies three novel genes. [FBrf0200993] Foley and O'Farrell, 2004, PLoS Biol. 2(8): e203 Functional dissection of an innate immune response by a genome-wide RNAi screen. [FBrf0179207]
Supplementary material	Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] Khanna et al., 2010, BMC Genomics 11(1): Towards a membrane proteome in Drosophila: a method for the isolation of plasma membrane. [FBrf0210978] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Perkins et al., 2009, Update to TRiP stock collection. Update to TRiP stock collection. [FBrf0208864] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335] Robertson, 2001.5.6, FlyBase error report on Sun May 06 00:40:30 2001. FlyBase error report on Sun May 06 00:40:30 2001. [FBrf0136023] Robertson, 2001.7.7, Third set of annotation suggestions from bee ESTs. Third set of annotation suggestions from bee ESTs. [FBrf0138600] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]
FlyBase analysis	FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]
Protein sequence record	Swiss-Prot Project Members, 2005.1.25, UniProtKB: Q9VE46 High-affinity choline transporter 1. [FBrf0182269]
Website	Fisher et al., 2012, BDGP insitu homepage BDGP insitu homepage [FBrf0219073]