FB2021_01, released Feb 18, 2021

Gene: Dmel\Mpc1

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General Information
Symbol
Dmel\Mpc1
Species
D. melanogaster
Name
Mitochondrial pyruvate carrier
Annotation Symbol
CG14290
Feature Type
protein_coding_gene
FlyBase ID
FBgn0038662
Gene Model Status
Current
Stock Availability
10 publicly available
Gene Snapshot
Mitochondrial pyruvate carrier (Mpc1) encodes an obligate subunit of the mitochondrial pyruvate carrier, which transports pyruvate across the mitochondrial inner membrane. [Date last reviewed: 2019-03-14]
Other Summaries
Also Known As

dMPC1

Key Links
Genomic Location
Cytogenetic map
91D5-91D5
Sequence location
3R:18,926,996..18,928,659 [-]
Recombination map

3-65

RefSeq locus
NT_033777 REGION:18926996..18928659
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (5 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables pyruvate transmembrane transporter activity
inferred from sequence or structural similarity with SGD:S000003048
(Bricker et al., 2012)
inferred from biological aspect of ancestor with PANTHER:PTN000365848
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in pyruvate metabolic process
inferred from mutant phenotype
(Bricker et al., 2012)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in mitochondrial pyruvate transmembrane transport
inferred from biological aspect of ancestor with PANTHER:PTN000365848
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity with SGD:S000003048
(Bricker et al., 2012)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in mitochondrion
inferred from direct assay
(Bricker et al., 2012)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in integral component of mitochondrial inner membrane
inferred from biological aspect of ancestor with PANTHER:PTN000365848
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity with SGD:S000003048
(Bricker et al., 2012)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (Q7KSC4)
Protein Signatures (InterPro)
Summaries
Protein Function (UniProtKB)
Mediates the uptake of pyruvate into mitochondria.
(UniProt, Q7KSC4)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Mpc1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.47

Low-frequency RNA-Seq exon junction(s) not annotated.

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Mpc1-RB
FBtr0083723
NM_142505
1058
107
Mpc1-RC
FBtr0334525
NM_001275791
1155
107
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Mpc1-PB
FBpp0083137
12.3
107
10.39
NP_650762
AAF55610
Mpc1-PC
FBpp0306592
12.3
107
10.39
NP_001262720
AGB96100
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

107 aa isoforms: Mpc1-PB, Mpc1-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

The functional 150 kDa pyruvate import complex is a heteromer of MPC1 and MPC2.

(UniProt, Q7KSC4)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Mpc1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult insulin secreting cell of pars intercerebralis
(McCommis et al., 2016)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in mitochondrion
inferred from direct assay
(Bricker et al., 2012)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Mpc1 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 3 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Mpc1
Transgenic constructs containing regulatory region of Mpc1
Aberrations (Deficiencies and Duplications) ( 3 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\MPC1
14 of 15
Yes
Yes
Hsap\MPC1L
4 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Mpc1
13 of 15
Yes
Yes
Mmus\Mpc1-ps
3 of 15
No
Yes
Mmus\Gm4984
2 of 15
No
Yes
Mmus\Gm13570
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (2)
Rnor\Mpc1
11 of 13
Yes
Yes
Rnor\Mpc1l
8 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\mpc1
9 of 12
Yes
Yes
Danio rerio (Zebrafish) (1)
Drer\mpc1
12 of 15
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\mpc-1
12 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (1)
Atha\AT5G20090
9 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\MPC1
12 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\SPCC1235.11
11 of 12
Yes
Yes
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190JKN )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00010115
Drosophila simulans
Dsim\GD20143
Drosophila sechellia
Dsec\GM18673
Drosophila erecta
Dere\GG16273
Drosophila yakuba
Dyak\GE25162
Drosophila ananassae
Dana\GF23011
Drosophila pseudoobscura pseudoobscura
Dpse\GA12882
Drosophila persimilis
Dper\GL24107
Drosophila willistoni
Dwil\GK22435
Drosophila virilis
Dvir\GJ14184
Drosophila mojavensis
Dmoj\GI22888
Drosophila grimshawi
Dgri\GH18736
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150F85 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17024681
Glossina morsitans
Tsetse fly
Gmor\GMOY007606
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_03803
Mayetiola destructor
Hessian fly
Mdes\Mdes000738
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL002860
Anopheles darlingi
American malaria mosquito
Adar\ADAC000227
Anopheles gambiae
Malaria mosquito
Agam\AGAP001417
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ003735
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0M26 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA002225
Danaus plexippus
Monarch butterfly
Dple\DPOGS208314-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL005781
Apis florea
Little honeybee
Aflo\2207475156
Apis mellifera
Western honey bee
Amel\LOC411677
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP21325
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP21343
Bombus terrestris
Buff-tailed bumblebee
Bter\15215848
Bombus terrestris
Buff-tailed bumblebee
Bter\15216914
Linepithema humile
Argentine ant
Lhum\LH15633
Linepithema humile
Argentine ant
Lhum\LH23587
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000190
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0001b5
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG003148
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG010188
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_11006
Tribolium castaneum
Red flour beetle
Tcas\TC000184
Pediculus humanus
Human body louse
Phum\PHUM268080
Rhodnius prolixus
Kissing bug
Rpro\RPRC001573
Cimex lectularius
Bed bug
Clec\CLEC013368
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI008014
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_12434
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0MA4 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR013165
Ixodes scapularis
Black-legged tick
Isca\ISCW015574
Tetranychus urticae
Two-spotted spider mite
Turt\tetur11g05640
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_129829
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_307796
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G15WB )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_018923gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Brp44lL
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_014597gn
Ciona intestinalis
Vase tunicate
Cint\LOC100175853
Gallus gallus
Domestic chicken
Ggal\BRP44L
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (3)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG9396
2 of 10
CG9399
2 of 10
CG32832
2 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 2 )
Potential Models Based on Orthology ( 1 )
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
MPC1; mitochondrial pyruvate carrier 1
14 of 15
614738
MPC1L; mitochondrial pyruvate carrier 1 like
4 of 15
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      esyN Network Diagram
      Interactions Browser
      Summary of Genetic Interactions
      esyN Network Diagram
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      External Data
      Subunit Structure (UniProtKB)
      The functional 150 kDa pyruvate import complex is a heteromer of MPC1 and MPC2.
      (UniProt, Q7KSC4 )
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      External Data
      Linkouts
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      3R
      Recombination map

      3-65

      Cytogenetic map
      91D5-91D5
      Sequence location
      3R:18,926,996..18,928,659 [-]
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      91D5-91D5
      Limits computationally determined from genome sequence between P{PZ}sprd05284 and P{PZ}cdi07013&P{lacW}nosj3B6
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      Experimentally Determined Recombination Data
      Location

      3-65

      (FlyBase, 2016)

      3-64.7

      (Comeron et al., 2012)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (10)
      Genomic Clones (22)
      cDNA Clones (27)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
      Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         

        polyclonal

        (Colca et al., 2013)
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of

        Source for identity of: CG14290 Mpc1

        (Bricker et al., 2012)
        Source for database merge of
        Additional comments
        Other Comments
        Origin and Etymology
        Discoverer
        Etymology
        Identification
        External Crossreferences and Linkouts ( 36 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        modMine - A data warehouse for the modENCODE project
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        FlyMine - An integrated database for Drosophila genomics
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        Synonyms and Secondary IDs (7)
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        References (43)