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Gene Dmel\Cyp12a5

General Information
Symbol	Dmel\Cyp12a5	Species	D. melanogaster
Name	Cyp12a5	Annotation symbol	CG11821
Feature type	protein_coding_gene	FlyBase ID	FBgn0038680
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	91F2-91F3	Sequence location	3R:14,958,174..14,960,426 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Cyp12a5 is referred to in FlyBase by the symbol Dmel\Cyp12a5 (CG11821, FBgn0038680). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: electron carrier activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: oxidation-reduction process. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Cytochrome P450; Cytochrome P450, E-class, group I; Cytochrome P450, conserved site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed during late larval stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult crop, larval/adult midgut, larval/adult hindgut, adult Malpighian tubules, adult heart, adult fat body, adult salivary gland, adult spermathecae, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1629771_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Cyp12a5. Gene sequence location is 3R:14958174..14960426.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 91F2-91F3   Limits computationally determined from genome sequence between P{PZ}cdi07013&P{lacW}nosj3B6 and P{PZ}l(3)0334603346
Experimentally Determined Cytological Location
Cytogenetic map Notes References 91F4-91F4     (Festucci-Buselli, 2003.11.5) 91F1-91F13     (Dunkov, 2000.6.29)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Cyp12a5 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Cyp12a5-RA FBtr0083730  NM_142525   2016   536
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Cyp12a5-PA   FBpp0083144   61.4   536   9.73     NP_650782   AAF55635
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Cytochrome P450 (IPR001128) Cytochrome P450, E-class, group I (IPR002401) Cytochrome P450, conserved site (IPR017972)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF55635   AY129460 AAM76202   AY459354 AAR88135   BI611862   BI633074   CO190105   CO194458   CO274801   CO320700   CO343704   DQ026292 AAY89654   EC083566   EC195479   EC250581   EC256211
UniProtKB/Swiss-Prot	Q9VE01
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult crop, larval/adult midgut, larval/adult hindgut, adult Malpighian tubules, adult heart, adult fat body, adult salivary gland, adult spermathecae, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    20.275 Larval Midgut    234.9 Larval Hindgut    347.4 Larval Malpighian Tubules    76.3 Larval Fat Body    1.4 Larval Salivary Gland    23.9 Larval Trachea    14.8 Larval Carcass    141.325 Adult Head    131.1 Adult Eye    51.375 Adult Brain    41.2 Adult Thoracic-Abdominal Ganglion    76.1 Adult Crop    104.9 Adult Midgut    480.8 Adult Hindgut    311.9 Adult Malpighian Tubules    327.1 Adult Fat Body    136.5 Adult Salivary Gland    135.5 Adult Heart    245.175 Adult VirginFemale Spermatheca    158 Adult InseminatedFemale Spermatheca    120.6 Adult Ovary    4.4 Adult Testis    24.5 Adult Male Accessory Gland    29 Adult Carcass    142 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    20.275 Larval Midgut    234.9 Larval Hindgut    347.4 Larval Malpighian Tubules    76.3 Larval Fat Body    1.4 Larval Salivary Gland    23.9 Larval Trachea    14.8 Larval Carcass    141.325 Adult Head    131.1 Adult Eye    51.375 Adult Brain    41.2 Adult Thoracic-Abdominal Ganglion    76.1 Adult Crop    104.9 Adult Midgut    480.8 Adult Hindgut    311.9 Adult Malpighian Tubules    327.1 Adult Fat Body    136.5 Adult Salivary Gland    135.5 Adult Heart    245.175 Adult VirginFemale Spermatheca    158 Adult InseminatedFemale Spermatheca    120.6 Adult Ovary    4.4 Adult Testis    24.5 Adult Male Accessory Gland    29 Adult Carcass    142 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    20.275 Larval Midgut    234.9 Larval Hindgut    347.4 Larval Malpighian Tubules    76.3 Larval Fat Body    1.4 Larval Salivary Gland    23.9 Larval Trachea    14.8 Larval Carcass    141.325 Adult Head    131.1 Adult Eye    51.375 Adult Brain    41.2 Adult Thoracic-Abdominal Ganglion    76.1 Adult Crop    104.9 Adult Midgut    480.8 Adult Hindgut    311.9 Adult Malpighian Tubules    327.1 Adult Fat Body    136.5 Adult Salivary Gland    135.5 Adult Heart    245.175 Adult VirginFemale Spermatheca    158 Adult InseminatedFemale Spermatheca    120.6 Adult Ovary    4.4 Adult Testis    24.5 Adult Male Accessory Gland    29 Adult Carcass    142 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    20.275 Larval Midgut    234.9 Larval Hindgut    347.4 Larval Malpighian Tubules    76.3 Larval Fat Body    1.4 Larval Salivary Gland    23.9 Larval Trachea    14.8 Larval Carcass    141.325 Adult Head    131.1 Adult Eye    51.375 Adult Brain    41.2 Adult Thoracic-Abdominal Ganglion    76.1 Adult Crop    104.9 Adult Midgut    480.8 Adult Hindgut    311.9 Adult Malpighian Tubules    327.1 Adult Fat Body    136.5 Adult Salivary Gland    135.5 Adult Heart    245.175 Adult VirginFemale Spermatheca    158 Adult InseminatedFemale Spermatheca    120.6 Adult Ovary    4.4 Adult Testis    24.5 Adult Male Accessory Gland    29 Adult Carcass    142 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    20.275 Larval Midgut    234.9 Larval Hindgut    347.4 Larval Malpighian Tubules    76.3 Larval Fat Body    1.4 Larval Salivary Gland    23.9 Larval Trachea    14.8 Larval Carcass    141.325 Adult Head    131.1 Adult Eye    51.375 Adult Brain    41.2 Adult Thoracic-Abdominal Ganglion    76.1 Adult Crop    104.9 Adult Midgut    480.8 Adult Hindgut    311.9 Adult Malpighian Tubules    327.1 Adult Fat Body    136.5 Adult Salivary Gland    135.5 Adult Heart    245.175 Adult VirginFemale Spermatheca    158 Adult InseminatedFemale Spermatheca    120.6 Adult Ovary    4.4 Adult Testis    24.5 Adult Male Accessory Gland    29 Adult Carcass    142 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    20.275 Larval Midgut    234.9 Larval Hindgut    347.4 Larval Malpighian Tubules    76.3 Larval Fat Body    1.4 Larval Salivary Gland    23.9 Larval Trachea    14.8 Larval Carcass    141.325 Adult Head    131.1 Adult Eye    51.375 Adult Brain    41.2 Adult Thoracic-Abdominal Ganglion    76.1 Adult Crop    104.9 Adult Midgut    480.8 Adult Hindgut    311.9 Adult Malpighian Tubules    327.1 Adult Fat Body    136.5 Adult Salivary Gland    135.5 Adult Heart    245.175 Adult VirginFemale Spermatheca    158 Adult InseminatedFemale Spermatheca    120.6 Adult Ovary    4.4 Adult Testis    24.5 Adult Male Accessory Gland    29 Adult Carcass    142 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    20.275 Larval Midgut    234.9 Larval Hindgut    347.4 Larval Malpighian Tubules    76.3 Larval Fat Body    1.4 Larval Salivary Gland    23.9 Larval Trachea    14.8 Larval Carcass    141.325 Adult Head    131.1 Adult Eye    51.375 Adult Brain    41.2 Adult Thoracic-Abdominal Ganglion    76.1 Adult Crop    104.9 Adult Midgut    480.8 Adult Hindgut    311.9 Adult Malpighian Tubules    327.1 Adult Fat Body    136.5 Adult Salivary Gland    135.5 Adult Heart    245.175 Adult VirginFemale Spermatheca    158 Adult InseminatedFemale Spermatheca    120.6 Adult Ovary    4.4 Adult Testis    24.5 Adult Male Accessory Gland    29 Adult Carcass    142 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    20.275 Larval Midgut    234.9 Larval Hindgut    347.4 Larval Malpighian Tubules    76.3 Larval Fat Body    1.4 Larval Salivary Gland    23.9 Larval Trachea    14.8 Larval Carcass    141.325 Adult Head    131.1 Adult Eye    51.375 Adult Brain    41.2 Adult Thoracic-Abdominal Ganglion    76.1 Adult Crop    104.9 Adult Midgut    480.8 Adult Hindgut    311.9 Adult Malpighian Tubules    327.1 Adult Fat Body    136.5 Adult Salivary Gland    135.5 Adult Heart    245.175 Adult VirginFemale Spermatheca    158 Adult InseminatedFemale Spermatheca    120.6 Adult Ovary    4.4 Adult Testis    24.5 Adult Male Accessory Gland    29 Adult Carcass    142 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    131.1   NA  Eye    51.375   NA  Brain    41.2   20.275  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    76.1   NA  Crop    104.9   234.9  Midgut    480.8   347.4  Hindgut    311.9   76.3  Malpighian Tubules    327.1   1.4  Fat Body    136.5   no informative data  Salivary Gland    135.5   NA  Heart    245.175   14.8  Trachea    NA   NA  VirginFemale Spermatheca    158   NA  InseminatedFemale Spermatheca    120.6   NA  Ovary    4.4   NA  Testis    24.5   NA  Male Accessory Gland    no informative data   141.325  Carcass    142 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    7 head, virgin 4-day female    10 head, virgin 20-day female    10 head, mated 1-day female    6 head, mated 4-day female    9 head, mated 20-day female    8 head, mated 1-day male    10 head, mated 4-day male    13 head, mated 20-day male    16 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    37 digestive system, 4-day adult    21 digestive system, 20-day adult    24 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    4 carcass, 1-day adult    9 carcass, 4-day adult    10 carcass, 20-day adult    8 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    7 head, virgin 4-day female    10 head, virgin 20-day female    10 head, mated 1-day female    6 head, mated 4-day female    9 head, mated 20-day female    8 head, mated 1-day male    10 head, mated 4-day male    13 head, mated 20-day male    16 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    16 digestive system, 1-day adult  (37) digestive system, 4-day adult    21 digestive system, 20-day adult    24 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    4 carcass, 1-day adult    9 carcass, 4-day adult    10 carcass, 20-day adult    8 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    7 head, virgin 4-day female    10 head, virgin 20-day female    10 head, mated 1-day female    6 head, mated 4-day female    9 head, mated 20-day female    8 head, mated 1-day male    10 head, mated 4-day male    13 head, mated 20-day male    16 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    37 digestive system, 4-day adult    21 digestive system, 20-day adult    24 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    4 carcass, 1-day adult    9 carcass, 4-day adult    10 carcass, 20-day adult    8 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    7 head, virgin 4-day female    10 head, virgin 20-day female    10 head, mated 1-day female    6 head, mated 4-day female    9 head, mated 20-day female    8 head, mated 1-day male    10 head, mated 4-day male    13 head, mated 20-day male    16 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    37 digestive system, 4-day adult    21 digestive system, 20-day adult    24 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    4 carcass, 1-day adult    9 carcass, 4-day adult    10 carcass, 20-day adult    8 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    7 head, virgin 4-day female    10 head, virgin 20-day female    10 head, mated 1-day female    6 head, mated 4-day female    9 head, mated 20-day female    8 head, mated 1-day male    10 head, mated 4-day male    13 head, mated 20-day male    16 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    37 digestive system, 4-day adult    21 digestive system, 20-day adult    24 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    4 carcass, 1-day adult    9 carcass, 4-day adult    10 carcass, 20-day adult    8 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    7 head, virgin 4-day female    10 head, virgin 20-day female    10 head, mated 1-day female    6 head, mated 4-day female    9 head, mated 20-day female    8 head, mated 1-day male    10 head, mated 4-day male    13 head, mated 20-day male    16 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    16 digestive system, 1-day adult  (37) digestive system, 4-day adult    21 digestive system, 20-day adult    24 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    4 carcass, 1-day adult    9 carcass, 4-day adult    10 carcass, 20-day adult    8 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    7 head, virgin 4-day female    10 head, virgin 20-day female    10 head, mated 1-day female    6 head, mated 4-day female    9 head, mated 20-day female    8 head, mated 1-day male    10 head, mated 4-day male    13 head, mated 20-day male    16 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    37 digestive system, 4-day adult    21 digestive system, 20-day adult    24 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    4 carcass, 1-day adult    9 carcass, 4-day adult    10 carcass, 20-day adult    8 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    7 head, virgin 4-day female    10 head, virgin 20-day female    10 head, mated 1-day female    6 head, mated 4-day female    9 head, mated 20-day female    8 head, mated 1-day male    10 head, mated 4-day male    13 head, mated 20-day male    16 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    37 digestive system, 4-day adult    21 digestive system, 20-day adult    24 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    4 carcass, 1-day adult    9 carcass, 4-day adult    10 carcass, 20-day adult    8 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed during late larval stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    1 embryo 20-22hr    8 embryo 22-24hr    10 larva L1    11 larva L2    10 larva L3 12hr old    16 larva L3 puffstage 1-2    22 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    6 white prepupae new    2 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    1 pupae 4d postWPP    3 adult male 01day    14 adult male 05day    17 adult male 30day    11 adult female 01day    7 adult female 05day    5 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    1 embryo 20-22hr    8 embryo 22-24hr    10 larva L1    11 larva L2    10 larva L3 12hr old    16 larva L3 puffstage 1-2    22 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    6 white prepupae new    2 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    1 pupae 4d postWPP    3 adult male 01day    14 adult male 05day    17 adult male 30day    11 adult female 01day    7 adult female 05day    5 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    1 embryo 20-22hr    8 embryo 22-24hr    10 larva L1    11 larva L2    10 larva L3 12hr old    16 larva L3 puffstage 1-2    22 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    6 white prepupae new    2 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    1 pupae 4d postWPP    3 adult male 01day    14 adult male 05day    17 adult male 30day    11 adult female 01day    7 adult female 05day    5 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    1 embryo 20-22hr    8 embryo 22-24hr    10 larva L1    11 larva L2    10 larva L3 12hr old    16 larva L3 puffstage 1-2    22 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    6 white prepupae new    2 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    1 pupae 4d postWPP    3 adult male 01day    14 adult male 05day    17 adult male 30day    11 adult female 01day    7 adult female 05day    5 adult female 30day    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    1 embryo 20-22hr    8 embryo 22-24hr    10 larva L1    11 larva L2    10 larva L3 12hr old    16 larva L3 puffstage 1-2    22 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    6 white prepupae new    2 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    1 pupae 4d postWPP    3 adult male 01day    14 adult male 05day    17 adult male 30day    11 adult female 01day    7 adult female 05day    5 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    1 embryo 20-22hr    8 embryo 22-24hr    10 larva L1    11 larva L2    10 larva L3 12hr old    16 larva L3 puffstage 1-2    22 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    6 white prepupae new    2 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    1 pupae 4d postWPP    3 adult male 01day    14 adult male 05day    17 adult male 30day    11 adult female 01day    7 adult female 05day    5 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    1 embryo 20-22hr    8 embryo 22-24hr    10 larva L1    11 larva L2    10 larva L3 12hr old    16 larva L3 puffstage 1-2    22 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    6 white prepupae new    2 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    1 pupae 4d postWPP    3 adult male 01day    14 adult male 05day    17 adult male 30day    11 adult female 01day    7 adult female 05day    5 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    1 embryo 20-22hr    8 embryo 22-24hr    10 larva L1    11 larva L2    10 larva L3 12hr old    16 larva L3 puffstage 1-2    22 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    6 white prepupae new    2 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    1 pupae 4d postWPP    3 adult male 01day    14 adult male 05day    17 adult male 30day    11 adult female 01day    7 adult female 05day    5 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    3 embryonic 1182-4H    0 embryonic GM2    1 embryonic Kc167    7 embryonic S1    0 embryonic S3    44 leg disc CME L1    3 wing disc CME-W2    2 wing disc ML-DmD8    10 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    12 ovary fGS/OSS    1 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    3 embryonic 1182-4H    0 embryonic GM2    1 embryonic Kc167    7 embryonic S1    0 embryonic S3  (44) leg disc CME L1    3 wing disc CME-W2    2 wing disc ML-DmD8    10 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    12 ovary fGS/OSS    1 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    3 embryonic 1182-4H    0 embryonic GM2    1 embryonic Kc167    7 embryonic S1    0 embryonic S3    44 leg disc CME L1    3 wing disc CME-W2    2 wing disc ML-DmD8    10 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    12 ovary fGS/OSS    1 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    3 embryonic 1182-4H    0 embryonic GM2    1 embryonic Kc167    7 embryonic S1    0 embryonic S3    44 leg disc CME L1    3 wing disc CME-W2    2 wing disc ML-DmD8    10 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    12 ovary fGS/OSS    1 ovary OSC    1 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    3 embryonic 1182-4H    0 embryonic GM2    1 embryonic Kc167    7 embryonic S1    0 embryonic S3    44 leg disc CME L1    3 wing disc CME-W2    2 wing disc ML-DmD8    10 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    12 ovary fGS/OSS    1 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    3 embryonic 1182-4H    0 embryonic GM2    1 embryonic Kc167    7 embryonic S1    0 embryonic S3  (44) leg disc CME L1    3 wing disc CME-W2    2 wing disc ML-DmD8    10 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    12 ovary fGS/OSS    1 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    3 embryonic 1182-4H    0 embryonic GM2    1 embryonic Kc167    7 embryonic S1    0 embryonic S3    44 leg disc CME L1    3 wing disc CME-W2    2 wing disc ML-DmD8    10 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    12 ovary fGS/OSS    1 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    3 embryonic 1182-4H    0 embryonic GM2    1 embryonic Kc167    7 embryonic S1    0 embryonic S3    44 leg disc CME L1    3 wing disc CME-W2    2 wing disc ML-DmD8    10 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    12 ovary fGS/OSS    1 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    2 heat shock, 4-day adult    25 Cadmium 50 mM 6 hrs, larvae L3    32 Cadmium 50 mM 12 hrs, larvae L3    28 Cadmium 50 mM 48 hrs, 4-day adult    34 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    103 Ethanol 10% 3 hrs, larvae L3    30 Caffeine 1.5 mg/ml 4 hrs, larvae L3    288 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    76 Rotenone 8 μg 12 hrs, larvae L3    74 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    2 heat shock, 4-day adult    25 Cadmium 50 mM 6 hrs, larvae L3  (32) Cadmium 50 mM 12 hrs, larvae L3  (28) Cadmium 50 mM 48 hrs, 4-day adult  (34) Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3  (103) Ethanol 10% 3 hrs, larvae L3  (30) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (288) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3  (76) Rotenone 8 μg 12 hrs, larvae L3  (74) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    2 heat shock, 4-day adult    25 Cadmium 50 mM 6 hrs, larvae L3    32 Cadmium 50 mM 12 hrs, larvae L3    28 Cadmium 50 mM 48 hrs, 4-day adult    34 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3  103 Ethanol 10% 3 hrs, larvae L3    30 Caffeine 1.5 mg/ml 4 hrs, larvae L3  (288) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    76 Rotenone 8 μg 12 hrs, larvae L3    74 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    2 heat shock, 4-day adult    25 Cadmium 50 mM 6 hrs, larvae L3    32 Cadmium 50 mM 12 hrs, larvae L3    28 Cadmium 50 mM 48 hrs, 4-day adult    34 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    103 Ethanol 10% 3 hrs, larvae L3    30 Caffeine 1.5 mg/ml 4 hrs, larvae L3    288 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    76 Rotenone 8 μg 12 hrs, larvae L3    74 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    2 heat shock, 4-day adult    25 Cadmium 50 mM 6 hrs, larvae L3    32 Cadmium 50 mM 12 hrs, larvae L3    28 Cadmium 50 mM 48 hrs, 4-day adult    34 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    103 Ethanol 10% 3 hrs, larvae L3    30 Caffeine 1.5 mg/ml 4 hrs, larvae L3    288 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    76 Rotenone 8 μg 12 hrs, larvae L3    74 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    2 heat shock, 4-day adult    25 Cadmium 50 mM 6 hrs, larvae L3  32 Cadmium 50 mM 12 hrs, larvae L3  28 Cadmium 50 mM 48 hrs, 4-day adult  (34) Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3  (103) Ethanol 10% 3 hrs, larvae L3  30 Caffeine 1.5 mg/ml 4 hrs, larvae L3  (288) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3  (76) Rotenone 8 μg 12 hrs, larvae L3  (74) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    2 heat shock, 4-day adult    25 Cadmium 50 mM 6 hrs, larvae L3    32 Cadmium 50 mM 12 hrs, larvae L3    28 Cadmium 50 mM 48 hrs, 4-day adult    34 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3  103 Ethanol 10% 3 hrs, larvae L3    30 Caffeine 1.5 mg/ml 4 hrs, larvae L3  (288) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    76 Rotenone 8 μg 12 hrs, larvae L3    74 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    2 heat shock, 4-day adult    25 Cadmium 50 mM 6 hrs, larvae L3    32 Cadmium 50 mM 12 hrs, larvae L3    28 Cadmium 50 mM 48 hrs, 4-day adult    34 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    103 Ethanol 10% 3 hrs, larvae L3    30 Caffeine 1.5 mg/ml 4 hrs, larvae L3    288 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    76 Rotenone 8 μg 12 hrs, larvae L3    74 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_16 mE1_20_mRNA_expression_cluster_17
External Data & Images
Linkouts	BDGP expression data • RH18307 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0038680 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11821-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 Cyp12a5GD12635 Cyp12a5GD17163 Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of Cyp12a5 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Cyp12a5 Class Mutagen Stocks Known lesion Cyp12a5GD12635 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Cyp12a5GD17163 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Cyp12a5KK103333 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Cyp12a5NIG.11821R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6183 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD12635} NA P{GD17163} NA P{KK103333} NA P{NIG.11821R} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
electron carrier activity inferred from electronic annotation with InterPro:IPR001128 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Dunkov, 1999.11, Dunkov, 2000.10.12) non-traceable author statement (Dunkov, 2000.6.29, Swiss-Prot Project Members, 2000.5.1) heme binding inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401 (FlyBase Curators et al., 2004-) iron ion binding inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401 (FlyBase Curators et al., 2004-) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401, InterPro:IPR017972 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
oxidation-reduction process inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401, InterPro:IPR017972 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
mitochondrion inferred from sequence or structural similarity (Dunkov, 1999.11, Dunkov, 2000.10.12) non-traceable author statement (Swiss-Prot Project Members, 2000.5.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Cyp12a5 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67291 DroID - A comprehensive database of gene and protein interactions. • FBgn0038680 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42293
Orthologs
OrthoDB Orthologs (57) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6QFWZZ Dipteran inclusive ortholog search EOG6Z62WZ Insect inclusive ortholog search EOG6R4XZ7 Arthropod inclusive ortholog search EOG6R2299 Metazoa inclusive ortholog search EOG6PZX0T
Orthologs in Drosophila Species (EOG6QFWZZ)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Cyp12a5     Drosophila melanogaster fruit fly  Dmel\Cyp12a4     Drosophila simulans   Dsim\GD19272   Y Drosophila simulans   Dsim\GD19273   Y Drosophila sechellia   Dsec\GM26824   Y Drosophila sechellia   Dsec\GM26823   Y Drosophila erecta   Dere\GG23142   Y Drosophila erecta   Dere\GG23147   Y Drosophila yakuba   Dyak\GE14755   Y Drosophila yakuba   Dyak\GE25584   Y Drosophila yakuba   Dyak\GE25583   Y Drosophila ananassae   Dana\GF16051   Y Drosophila ananassae   Dana\GF16050   Y Drosophila ananassae   Dana\GF16049   Y Drosophila pseudoobscura pseudoobscura   Dpse\GA27066   Y Drosophila pseudoobscura pseudoobscura   Dpse\GA11217   Y Drosophila pseudoobscura pseudoobscura   Dpse\GA22196   Y Drosophila pseudoobscura pseudoobscura   Dpse\GA27063   Y Drosophila pseudoobscura pseudoobscura   Dpse\GA27064   Y Drosophila persimilis   Dper\GL23820   Y Drosophila persimilis   Dper\GL23821 Y Y Drosophila persimilis   Dper\GL23823   Y Drosophila persimilis   Dper\GL23822   Y Drosophila willistoni   Dwil\GK24811   Y Drosophila willistoni   Dwil\GK22742   Y Drosophila virilis   Dvir\GJ23534   Y Drosophila mojavensis   Dmoj\GI23556   Y Drosophila grimshawi   Dgri\GH23658   Y Drosophila grimshawi   Dgri\GH23655   Y
Orthologs in non-Drosophila Dipterans (EOG6Z62WZ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL001960 Y Aedes aegypti Yellow fever mosquito  Aaeg\CYP12F8 Y Aedes aegypti Yellow fever mosquito  Aaeg\CYP12F6 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL002031 Y Anopheles gambiae Malaria mosquito  Agam\AGAP012800 Y Anopheles gambiae Malaria mosquito  Agam\AGAP008019 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ800150 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ800149 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ800148 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ800146 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ800147 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ010226 Y
Orthologs in non-Dipteran Insects (EOG6R4XZ7)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG013694 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH16942 Y Atta cephalotes Leafcutter ant  Acep\ACEP21373 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO19269 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO14481 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL20031 Y Linepithema humile Argentine ant  Lhum\LH17599 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB20836 Y Solenopsis invicta Red fire ant  Sinv\SINV13068 Y Bombyx mori Silkmoth  Bmor\BGIBMGA005356 Y Bombyx mori Silkmoth  Bmor\BGIBMGA001277 Y Bombyx mori Silkmoth  Bmor\BGIBMGA001276 Y Pediculus humanus Human body louse  Phum\PHUM120320 Y Tribolium castaneum Red flour beetle  Tcas\CYP12H1 Y
Orthologs in non-Insect Arthropods (EOG6R2299)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_319971 Y Ixodes scapularis Deer tick  Isca\ISCW001527 Y
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (1) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila persimilis Dper\GL23821
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
VDRC	v103961 P{KK103333}VIE-260B v26798 w1118 P{GD12635}v26798 v26796 w1118; P{GD12635}v26796 v46858 w1118; P{GD17163}v46858
Genomic Clones ( 2 )
	BACR17F04 BACR48G05 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 11 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RH18307
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	SD27045
Other clones	13565 181367 214533.62 CK01.57B.G10 EC38606 EK046559 EK115525 EK287244 EP17852
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0038680 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42293
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_142525 RefSeq (Proteins) • NP_650782 DDBJ / EMBL / GenBank • AAF55635 AAM76202 AAR88135 AAY89654 AY129460 AY459354 BI611862 DQ026292 Entrez Gene - A searchable database of RefSeq genes. • 42293 UniProtKB/Swiss-Prot • Q9VE01
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Cytochrome P450 (IPR001128) Cytochrome P450, E-class, group I (IPR002401) Cytochrome P450, conserved site (IPR017972) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RH18307
Linkouts
	BioGRID - A database of protein and genetic interactions • 67291 DroID - A comprehensive database of gene and protein interactions. • FBgn0038680 DRSC - Results from RNAi screens. • FBgn0038680 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0038680 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11821-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0038680 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42293 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42293 modMine - Data generated by the modENCODE project. • FBgn0038680
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	12a5 (Nelson, 2001.2.5) CG11821 (Mosallanejad et al., 2010, Keleman et al., 2009.8.5) Cyp12a5 (Turner et al., 2008, Niwa et al., 2011, Gallach et al., 2010, Shieh and Bonini, 2011, Festucci-Buselli et al., 2005, Vorobyeva et al., 2011, Japanese National Institute of Genetics, 2012.5.21)
Name Synonym	Cyp12a5   cytochrome P450 (Chung et al., 2009)
Secondary FlyBase IDs
References ( 33 )
Generate a list of	All references relating to this gene ( 33 )
List References by type	Research paper  ( 12 ) Supplementary material  ( 4 ) Review  ( 1 ) Personal communication to FlyBase  ( 9 ) FlyBase analysis  ( 1 ) Stock list  ( 1 ) DNA/RNA sequence record  ( 1 ) Curated genome annotation  ( 2 ) Protein sequence record  ( 1 )
Recent research papers ( 3 )
	Niwa et al., 2011, Appl. Ent. Zool. 46(4): 533--543 Expressions of the cytochrome P450 monooxygenase gene Cyp4g1 and its homolog in the prothoracic glands of the fruit fly Drosophila melanogaster (Diptera: Drosophilidae) and the silkworm Bombyx mori (Lepidoptera: Bombycidae). [FBrf0216541] Shieh and Bonini, 2011, Hum. Mol. Genet. 20(24): 4810--4821 Genes and pathways affected by CAG-repeat RNA-based toxicity in Drosophila. [FBrf0216738] Vorobyeva et al., 2011, Cell Cycle 10(11): 1821--1827 SAYP interacts with DHR3 nuclear receptor and participates in ecdysone-dependent transcription regulation. [FBrf0213948] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...