• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\CG4562

General Information
Symbol	Dmel\CG4562	Species	D. melanogaster
Name		Annotation symbol	CG4562
Feature type	protein_coding_gene	FlyBase ID	FBgn0038740
Gene Model Status	Current	Stock availability	6 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	92B4-92B4	Sequence location	3R:15,691,139..15,701,400 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG4562 (FBgn0038740). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: ATPase activity, coupled to transmembrane movement of substances; transporter activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: transmembrane transport. 7 alleles are reported. No phenotypic data is available. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: AAA+ ATPase domain; ABC transporter, conserved site; ABC transporter, integral membrane type 1; ABC transporter, transmembrane domain; ABC transporter, transmembrane domain, type 1; ABC transporter-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult midgut. Expression at moderate levels in the following post-embryonic organs or tissues: larval midgut, adult Malpighian tubules. Comments on Affy2 ProbeSet: ProbeSet 1625778_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of CG4562. Gene sequence location is 3R:15691139..15701400.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 92B4-92B4   Limits computationally determined from genome sequence between P{PZ}l(3)1058510585 and P{EP}SyndEP409
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG4562 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	gene_with_stop_codon_read_through ; SO:0000697 Gene model reviewed during 5.44 Stop-codon suppression (UGA) postulated; FBrf0216884. Gene model reviewed during 5.47 Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG4562-RA FBtr0083859  NM_142581   4825   1362 CG4562-RB FBtr0113250  NM_001104371   4539   948 CG4562-RC FBtr0330034  NM_001275816   6512   1362 CG4562-RD FBtr0330035  NM_001275817   4764   948 CG4562-RE FBtr0330036  NM_001275818   4825   1408
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG4562-PA   FBpp0083268   152.8   1362   9.11     NP_650838   AAF55707 CG4562-PB   FBpp0112162   106.8   948   9.94     NP_001097841   ABW08706 CG4562-PC   FBpp0303067   152.8   1362   9.11     NP_001262745   AGB96125 CG4562-PD   FBpp0303068   106.8   948   9.94     NP_001262746   AGB96126 CG4562-PE   FBpp0303069   157.8   1408   9.25     NP_001262747   AGB96127
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • ABC transporter, transmembrane domain (IPR001140) ABC transporter-like (IPR003439) AAA+ ATPase domain (IPR003593) ABC transporter, transmembrane domain, type 1 (IPR011527) P-loop containing nucleoside triphosphate hydrolase (IPR027417) ABC transporter, conserved site (IPR017871) ABC transporter, integral membrane type 1 (IPR017940)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141204   AA141205   AE014297 AAF55707   AE014297 ABW08706   AE014297 AGB96125   AE014297 AGB96126   AE014297 AGB96127   BI215079   BI231057   BI373126   BI579899   BT021352 AAX33500   CZ467928   CZ483553   CZ483554   EC226117   FD585551   FD585579   FD585649   FD585991   FD585999   FD586034   FD586520   FD587284   GH746627   GH762107   GH767154   GH769886
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q5BI72 Q9VDT3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult midgut. Expression at moderate levels in the following post-embryonic organs or tissues: larval midgut, adult Malpighian tubules. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    9.675 Larval Midgut    277.7 Larval Hindgut    2.2 Larval Malpighian Tubules    28.1 Larval Fat Body    27.5 Larval Salivary Gland    8.9 Larval Trachea    4.85 Larval Carcass    1.775 Adult Head    12.7 Adult Eye    10.725 Adult Brain    70.3 Adult Thoracic-Abdominal Ganglion    45.5 Adult Crop    9.9 Adult Midgut    844.1 Adult Hindgut    45 Adult Malpighian Tubules    136.9 Adult Fat Body    4.4 Adult Salivary Gland    11.7 Adult Heart    4.475 Adult VirginFemale Spermatheca    4 Adult InseminatedFemale Spermatheca    4.5 Adult Ovary    43.8 Adult Testis    78.2 Adult Male Accessory Gland    15.6 Adult Carcass    13.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    9.675 Larval Midgut    277.7 Larval Hindgut    2.2 Larval Malpighian Tubules    28.1 Larval Fat Body    27.5 Larval Salivary Gland    8.9 Larval Trachea    4.85 Larval Carcass    1.775 Adult Head    12.7 Adult Eye    10.725 Adult Brain    70.3 Adult Thoracic-Abdominal Ganglion    45.5 Adult Crop    9.9 Adult Midgut  (844.1) Adult Hindgut    45 Adult Malpighian Tubules    136.9 Adult Fat Body    4.4 Adult Salivary Gland    11.7 Adult Heart    4.475 Adult VirginFemale Spermatheca    4 Adult InseminatedFemale Spermatheca    4.5 Adult Ovary    43.8 Adult Testis    78.2 Adult Male Accessory Gland    15.6 Adult Carcass    13.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    9.675 Larval Midgut    277.7 Larval Hindgut    2.2 Larval Malpighian Tubules    28.1 Larval Fat Body    27.5 Larval Salivary Gland    8.9 Larval Trachea    4.85 Larval Carcass    1.775 Adult Head    12.7 Adult Eye    10.725 Adult Brain    70.3 Adult Thoracic-Abdominal Ganglion    45.5 Adult Crop    9.9 Adult Midgut    844.1 Adult Hindgut    45 Adult Malpighian Tubules    136.9 Adult Fat Body    4.4 Adult Salivary Gland    11.7 Adult Heart    4.475 Adult VirginFemale Spermatheca    4 Adult InseminatedFemale Spermatheca    4.5 Adult Ovary    43.8 Adult Testis    78.2 Adult Male Accessory Gland    15.6 Adult Carcass    13.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    9.675 Larval Midgut    277.7 Larval Hindgut    2.2 Larval Malpighian Tubules    28.1 Larval Fat Body    27.5 Larval Salivary Gland    8.9 Larval Trachea    4.85 Larval Carcass    1.775 Adult Head    12.7 Adult Eye    10.725 Adult Brain    70.3 Adult Thoracic-Abdominal Ganglion    45.5 Adult Crop    9.9 Adult Midgut    844.1 Adult Hindgut    45 Adult Malpighian Tubules    136.9 Adult Fat Body    4.4 Adult Salivary Gland    11.7 Adult Heart    4.475 Adult VirginFemale Spermatheca    4 Adult InseminatedFemale Spermatheca    4.5 Adult Ovary    43.8 Adult Testis    78.2 Adult Male Accessory Gland    15.6 Adult Carcass    13.7 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    9.675 Larval Midgut    277.7 Larval Hindgut    2.2 Larval Malpighian Tubules    28.1 Larval Fat Body    27.5 Larval Salivary Gland    8.9 Larval Trachea    4.85 Larval Carcass    1.775 Adult Head    12.7 Adult Eye    10.725 Adult Brain    70.3 Adult Thoracic-Abdominal Ganglion    45.5 Adult Crop    9.9 Adult Midgut    844.1 Adult Hindgut    45 Adult Malpighian Tubules    136.9 Adult Fat Body    4.4 Adult Salivary Gland    11.7 Adult Heart    4.475 Adult VirginFemale Spermatheca    4 Adult InseminatedFemale Spermatheca    4.5 Adult Ovary    43.8 Adult Testis    78.2 Adult Male Accessory Gland    15.6 Adult Carcass    13.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    9.675 Larval Midgut    277.7 Larval Hindgut    2.2 Larval Malpighian Tubules    28.1 Larval Fat Body    27.5 Larval Salivary Gland    8.9 Larval Trachea    4.85 Larval Carcass    1.775 Adult Head    12.7 Adult Eye    10.725 Adult Brain    70.3 Adult Thoracic-Abdominal Ganglion    45.5 Adult Crop    9.9 Adult Midgut  (844.1) Adult Hindgut    45 Adult Malpighian Tubules    136.9 Adult Fat Body    4.4 Adult Salivary Gland    11.7 Adult Heart    4.475 Adult VirginFemale Spermatheca    4 Adult InseminatedFemale Spermatheca    4.5 Adult Ovary    43.8 Adult Testis    78.2 Adult Male Accessory Gland    15.6 Adult Carcass    13.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    9.675 Larval Midgut    277.7 Larval Hindgut    2.2 Larval Malpighian Tubules    28.1 Larval Fat Body    27.5 Larval Salivary Gland    8.9 Larval Trachea    4.85 Larval Carcass    1.775 Adult Head    12.7 Adult Eye    10.725 Adult Brain    70.3 Adult Thoracic-Abdominal Ganglion    45.5 Adult Crop    9.9 Adult Midgut    844.1 Adult Hindgut    45 Adult Malpighian Tubules    136.9 Adult Fat Body    4.4 Adult Salivary Gland    11.7 Adult Heart    4.475 Adult VirginFemale Spermatheca    4 Adult InseminatedFemale Spermatheca    4.5 Adult Ovary    43.8 Adult Testis    78.2 Adult Male Accessory Gland    15.6 Adult Carcass    13.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    9.675 Larval Midgut    277.7 Larval Hindgut    2.2 Larval Malpighian Tubules    28.1 Larval Fat Body    27.5 Larval Salivary Gland    8.9 Larval Trachea    4.85 Larval Carcass    1.775 Adult Head    12.7 Adult Eye    10.725 Adult Brain    70.3 Adult Thoracic-Abdominal Ganglion    45.5 Adult Crop    9.9 Adult Midgut    844.1 Adult Hindgut    45 Adult Malpighian Tubules    136.9 Adult Fat Body    4.4 Adult Salivary Gland    11.7 Adult Heart    4.475 Adult VirginFemale Spermatheca    4 Adult InseminatedFemale Spermatheca    4.5 Adult Ovary    43.8 Adult Testis    78.2 Adult Male Accessory Gland    15.6 Adult Carcass    13.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    no informative data   NA  Eye    no informative data   NA  Brain    70.3   9.675  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    45.5   NA  Crop    9.9   277.7  Midgut    844.1   2.2  Hindgut    45   no informative data  Malpighian Tubules    136.9   no informative data  Fat Body    4.4   8.9  Salivary Gland    no informative data   NA  Heart    4.475   4.85  Trachea    NA   NA  VirginFemale Spermatheca    4   NA  InseminatedFemale Spermatheca    4.5   NA  Ovary    43.8   NA  Testis    78.2   NA  Male Accessory Gland    no informative data   1.775  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    2 central nervous system, pupae P8    6 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    3 head, mated 4-day male    3 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    69 digestive system, 4-day adult    71 digestive system, 20-day adult    48 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    2 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    3 ovary, mated 4-day female    2 testis, mated 4-day male    10 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    2 central nervous system, pupae P8    6 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    3 head, mated 4-day male    3 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    5 digestive system, 1-day adult  (69) digestive system, 4-day adult  (71) digestive system, 20-day adult  (48) fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    2 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    3 ovary, mated 4-day female    2 testis, mated 4-day male    10 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    2 central nervous system, pupae P8    6 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    3 head, mated 4-day male    3 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    69 digestive system, 4-day adult    71 digestive system, 20-day adult    48 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    2 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    3 ovary, mated 4-day female    2 testis, mated 4-day male    10 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    2 central nervous system, pupae P8    6 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    3 head, mated 4-day male    3 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    69 digestive system, 4-day adult    71 digestive system, 20-day adult    48 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    2 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    3 ovary, mated 4-day female    2 testis, mated 4-day male    10 accessory gland, mated 4-day male    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    2 central nervous system, pupae P8    6 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    3 head, mated 4-day male    3 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    69 digestive system, 4-day adult    71 digestive system, 20-day adult    48 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    2 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    3 ovary, mated 4-day female    2 testis, mated 4-day male    10 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    2 central nervous system, pupae P8    6 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    3 head, mated 4-day male    3 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    5 digestive system, 1-day adult  (69) digestive system, 4-day adult  (71) digestive system, 20-day adult  (48) fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    2 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    3 ovary, mated 4-day female    2 testis, mated 4-day male    10 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    2 central nervous system, pupae P8    6 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    3 head, mated 4-day male    3 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    69 digestive system, 4-day adult    71 digestive system, 20-day adult    48 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    2 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    3 ovary, mated 4-day female    2 testis, mated 4-day male    10 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    2 central nervous system, pupae P8    6 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    3 head, mated 4-day male    3 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    69 digestive system, 4-day adult    71 digestive system, 20-day adult    48 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    2 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    3 ovary, mated 4-day female    2 testis, mated 4-day male    10 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    2 embryo 12-14hr    4 embryo 14-16hr    17 embryo 16-18hr    27 embryo 18-20hr    47 embryo 20-22hr    84 embryo 22-24hr    80 larva L1    49 larva L2    36 larva L3 12hr old    19 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    4 white prepupae new    7 white prepupae 12hr    40 white prepupae 24hr    23 pupae 2d postWPP    14 pupae 3d postWPP    9 pupae 4d postWPP    26 adult male 01day    32 adult male 05day    32 adult male 30day    30 adult female 01day    36 adult female 05day    17 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    2 embryo 12-14hr    4 embryo 14-16hr    17 embryo 16-18hr  (27) embryo 18-20hr  (47) embryo 20-22hr  (84) embryo 22-24hr  (80) larva L1  (49) larva L2  (36) larva L3 12hr old    19 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    4 white prepupae new    7 white prepupae 12hr  (40) white prepupae 24hr    23 pupae 2d postWPP    14 pupae 3d postWPP    9 pupae 4d postWPP  26 adult male 01day  (32) adult male 05day  (32) adult male 30day  (30) adult female 01day  (36) adult female 05day    17 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    2 embryo 12-14hr    4 embryo 14-16hr    17 embryo 16-18hr    27 embryo 18-20hr    47 embryo 20-22hr    84 embryo 22-24hr    80 larva L1    49 larva L2    36 larva L3 12hr old    19 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    4 white prepupae new    7 white prepupae 12hr    40 white prepupae 24hr    23 pupae 2d postWPP    14 pupae 3d postWPP    9 pupae 4d postWPP    26 adult male 01day    32 adult male 05day    32 adult male 30day    30 adult female 01day    36 adult female 05day    17 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    2 embryo 12-14hr    4 embryo 14-16hr    17 embryo 16-18hr    27 embryo 18-20hr    47 embryo 20-22hr    84 embryo 22-24hr    80 larva L1    49 larva L2    36 larva L3 12hr old    19 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    4 white prepupae new    7 white prepupae 12hr    40 white prepupae 24hr    23 pupae 2d postWPP    14 pupae 3d postWPP    9 pupae 4d postWPP    26 adult male 01day    32 adult male 05day    32 adult male 30day    30 adult female 01day    36 adult female 05day    17 adult female 30day    18 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    2 embryo 12-14hr    4 embryo 14-16hr    17 embryo 16-18hr    27 embryo 18-20hr    47 embryo 20-22hr    84 embryo 22-24hr    80 larva L1    49 larva L2    36 larva L3 12hr old    19 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    4 white prepupae new    7 white prepupae 12hr    40 white prepupae 24hr    23 pupae 2d postWPP    14 pupae 3d postWPP    9 pupae 4d postWPP    26 adult male 01day    32 adult male 05day    32 adult male 30day    30 adult female 01day    36 adult female 05day    17 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    2 embryo 12-14hr    4 embryo 14-16hr    17 embryo 16-18hr  27 embryo 18-20hr  (47) embryo 20-22hr  (84) embryo 22-24hr  (80) larva L1  (49) larva L2  (36) larva L3 12hr old    19 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    4 white prepupae new    7 white prepupae 12hr  (40) white prepupae 24hr    23 pupae 2d postWPP    14 pupae 3d postWPP    9 pupae 4d postWPP  26 adult male 01day  32 adult male 05day  32 adult male 30day  30 adult female 01day  (36) adult female 05day    17 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    2 embryo 12-14hr    4 embryo 14-16hr    17 embryo 16-18hr    27 embryo 18-20hr    47 embryo 20-22hr    84 embryo 22-24hr    80 larva L1    49 larva L2    36 larva L3 12hr old    19 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    4 white prepupae new    7 white prepupae 12hr    40 white prepupae 24hr    23 pupae 2d postWPP    14 pupae 3d postWPP    9 pupae 4d postWPP    26 adult male 01day    32 adult male 05day    32 adult male 30day    30 adult female 01day    36 adult female 05day    17 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    2 embryo 12-14hr    4 embryo 14-16hr    17 embryo 16-18hr    27 embryo 18-20hr    47 embryo 20-22hr    84 embryo 22-24hr    80 larva L1    49 larva L2    36 larva L3 12hr old    19 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    4 white prepupae new    7 white prepupae 12hr    40 white prepupae 24hr    23 pupae 2d postWPP    14 pupae 3d postWPP    9 pupae 4d postWPP    26 adult male 01day    32 adult male 05day    32 adult male 30day    30 adult female 01day    36 adult female 05day    17 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    2 embryonic GM2    4 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    1 wing disc CME-W2    8 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    1 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    2 embryonic GM2    4 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    1 wing disc CME-W2    8 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    1 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    2 embryonic GM2    4 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    1 wing disc CME-W2    8 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    1 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    2 embryonic GM2    4 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    1 wing disc CME-W2    8 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    1 ovary OSC    0 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    2 embryonic GM2    4 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    1 wing disc CME-W2    8 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    1 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    2 embryonic GM2    4 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    1 wing disc CME-W2    8 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    1 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    2 embryonic GM2    4 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    1 wing disc CME-W2    8 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    1 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    2 embryonic GM2    4 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    1 wing disc CME-W2    8 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    1 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    10 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    10 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    10 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    10 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    10 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    10 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    10 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    13 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    10 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_10 mE1_20_mRNA_expression_cluster_15
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0038740 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4562-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG4562GD3073 Phenotype manifest in Allele
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of CG4562 Class Mutagen Stocks Known lesion CG4562c02418 piggyBac transposase 1 -- CG4562EY09703 1 -- CG4562f01067 piggyBac transposase 1 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG4562 Class Mutagen Stocks Known lesion CG4562GD3073 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG4562HMS00623 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG4562KK100405 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG4562NIG.4562R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD3073} NA P{KK100405} NA P{NIG.4562R} NA P{TRiP.HMS00623} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}CG4562EY09703 NA miscellaneous insertions PBac{PB}CG4562c02418 NA PBac{WH}CG4562f01067 NA
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
ATPase activity, coupled to transmembrane movement of substances inferred from sequence or structural similarity with EMBL:AF071202 (FlyBase, 1992-) ATP binding inferred from electronic annotation with InterPro:IPR001140, InterPro:IPR003439, InterPro:IPR011527, InterPro:IPR017871 (FlyBase Curators et al., 2004-) transporter activity inferred from sequence or structural similarity with EMBL:AF071202 (FlyBase, 1992-)
Biological Process
CV term Evidence References
transmembrane transport inferred from electronic annotation with InterPro:IPR001140, InterPro:IPR011527 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
ATP-binding cassette (ABC) transporter complex inferred from sequence or structural similarity with EMBL:AF071202 (FlyBase, 1992-) integral to membrane inferred from electronic annotation with InterPro:IPR001140, InterPro:IPR011527 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	gene_with_stop_codon_read_through (Jungreis et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG4562 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67352 DroID - A comprehensive database of gene and protein interactions. • FBgn0038740 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42362
Orthologs
OrthoDB Orthologs (168) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG64BBMH Dipteran inclusive ortholog search EOG6V177S Insect inclusive ortholog search EOG66WX48 Arthropod inclusive ortholog search EOG6DBRVF Metazoa inclusive ortholog search EOG65BD76
Orthologs in Drosophila Species (EOG64BBMH)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG4562     Drosophila simulans   Dsim\GD20097 Y   Drosophila sechellia   Dsec\GM26890     Drosophila erecta   Dere\GG15808     Drosophila yakuba   Dyak\GE25109     Drosophila ananassae   Dana\GF17354 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA18260 Y   Drosophila willistoni   Dwil\GK22360 Y   Drosophila virilis   Dvir\GJ10184     Drosophila mojavensis   Dmoj\GI10329     Drosophila grimshawi   Dgri\GH23331
Orthologs in non-Drosophila Dipterans (EOG6V177S)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL013854 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL013567 Y Anopheles gambiae Malaria mosquito  Agam\AGAP006427 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ016918 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ004604 Y
Orthologs in non-Dipteran Insects (EOG66WX48)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB43189 Y Apis mellifera Western honey bee  Amel\GB48573 Y Apis mellifera Western honey bee  Amel\GB50195 Y Apis mellifera Western honey bee  Amel\LOC551061 Y Apis mellifera Western honey bee  Amel\GB45278 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG005769 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG014001 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG013995 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG005771 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG005619 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG005939 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG001436 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG005743 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG005949 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG005940 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG021419 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007473 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG022099 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG008391 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG001435 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG005946 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG001437 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG005944 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG015638 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH20970 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH25144 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH25142 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH25143 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH25138 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH18076 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH25145 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH25137 Y Atta cephalotes Leafcutter ant  Acep\ACEP20247 Y Atta cephalotes Leafcutter ant  Acep\ACEP25775 Y Atta cephalotes Leafcutter ant  Acep\ACEP19448 Y Atta cephalotes Leafcutter ant  Acep\ACEP10888 Y Atta cephalotes Leafcutter ant  Acep\ACEP10899 Y Atta cephalotes Leafcutter ant  Acep\ACEP10892 Y Atta cephalotes Leafcutter ant  Acep\ACEP10901 Y Atta cephalotes Leafcutter ant  Acep\ACEP10903 Y Atta cephalotes Leafcutter ant  Acep\ACEP10882 Y Atta cephalotes Leafcutter ant  Acep\ACEP10902 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO23510 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO13349 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO23511 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO14835 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO23512 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL17005 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL18589 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL23459 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL23460 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL16445 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL23461 Y Linepithema humile Argentine ant  Lhum\LH25761 Y Linepithema humile Argentine ant  Lhum\LH22562 Y Linepithema humile Argentine ant  Lhum\LH22565 Y Linepithema humile Argentine ant  Lhum\LH12079 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB18191 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB18190 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB18184 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB11368 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB12060 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB18192 Y Solenopsis invicta Red fire ant  Sinv\SINV16600 Y Solenopsis invicta Red fire ant  Sinv\SINV11461 Y Solenopsis invicta Red fire ant  Sinv\SINV15752 Y Solenopsis invicta Red fire ant  Sinv\SINV14284 Y Solenopsis invicta Red fire ant  Sinv\SINV14289 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI23911 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI070177 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI007210 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI000359 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI008595 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI061687 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI38602 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI084024 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI001507 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI005339 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI006442 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI004533 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI004675 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI006979 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI008842 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI002363 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI001390 Y Bombyx mori Silkmoth  Bmor\BGIBMGA007738 Y Bombyx mori Silkmoth  Bmor\BGIBMGA007735 Y Bombyx mori Silkmoth  Bmor\BGIBMGA010849 Y Bombyx mori Silkmoth  Bmor\BGIBMGA003359 Y Pediculus humanus Human body louse  Phum\PHUM075990 Y Pediculus humanus Human body louse  Phum\PHUM513390 Y Tribolium castaneum Red flour beetle  Tcas\TC013751 Y Tribolium castaneum Red flour beetle  Tcas\TC014092 Y Tribolium castaneum Red flour beetle  Tcas\TC009892 Y Tribolium castaneum Red flour beetle  Tcas\TC010434 Y Tribolium castaneum Red flour beetle  Tcas\TC013750 Y Tribolium castaneum Red flour beetle  Tcas\TC009891 Y Tribolium castaneum Red flour beetle  Tcas\TC013749 Y Tribolium castaneum Red flour beetle  Tcas\TC014589 Y Tribolium castaneum Red flour beetle  Tcas\TC014776 Y Tribolium castaneum Red flour beetle  Tcas\TC014775 Y Tribolium castaneum Red flour beetle  Tcas\TC014089 Y Tribolium castaneum Red flour beetle  Tcas\TC014403 Y
Orthologs in non-Insect Arthropods (EOG6DBRVF)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_347288 Y Daphnia pulex Water flea  Dpux\Ttc29 Y Ixodes scapularis Deer tick  Isca\ISCW019069 Y
Orthologs in non-Arthropod Metazoa (EOG65BD76)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\mrp-2 Y Caenorhabditis elegans Nematode  Cele\mrp-3 Y Caenorhabditis elegans Nematode  Cele\mrp-6 Y Caenorhabditis elegans Nematode  Cele\mrp-1 Y Caenorhabditis elegans Nematode  Cele\mrp-4 Y Caenorhabditis elegans Nematode  Cele\mrp-8 Y Caenorhabditis elegans Nematode  Cele\mrp-7 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_002346gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_023862gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_026395gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_021103gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_014214gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_011617gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_020669gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_002411gn Y Danio rerio Zebrafish  Drer\ENSDARG00000077243 Y Danio rerio Zebrafish  Drer\ENSDARG00000094901 Y Danio rerio Zebrafish  Drer\ENSDARG00000009582 Y Danio rerio Zebrafish  Drer\abcc4 Y Danio rerio Zebrafish  Drer\abcc2 Y Danio rerio Zebrafish  Drer\BX548046.1 Y Danio rerio Zebrafish  Drer\ENSDARG00000059874 Y Xenopus tropicalis Western clawed frog  Xtro\abcc6 Y Xenopus tropicalis Western clawed frog  Xtro\abcc4 Y Xenopus tropicalis Western clawed frog  Xtro\abcc2 Y Xenopus tropicalis Western clawed frog  Xtro\abcc1 Y Xenopus tropicalis Western clawed frog  Xtro\abcc3 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000033617 Y Gallus gallus Domestic chicken  Ggal\ABCC4 Y Gallus gallus Domestic chicken  Ggal\LOC416599 Y Gallus gallus Domestic chicken  Ggal\ABCC2 Y Gallus gallus Domestic chicken  Ggal\ABCC3 Y Gallus gallus Domestic chicken  Ggal\ENSGALG00000015675 Y Gallus gallus Domestic chicken  Ggal\ABCC1 Y Mus musculus House mouse  Mmus\ENSMUSG00000020865 Y Mus musculus House mouse  Mmus\Abcc2 Y Mus musculus House mouse  Mmus\Abcc1 Y Mus musculus House mouse  Mmus\Abcc4 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000027663 Y Rattus norvegicus Norway rat  Rnor\Abcc1 Y Rattus norvegicus Norway rat  Rnor\Abcc4 Y Rattus norvegicus Norway rat  Rnor\Abcc3 Y Homo sapiens Human  Hsap\ENSG00000108846 Y Homo sapiens Human  Hsap\ABCC4 Y Homo sapiens Human  Hsap\ABCC2 Y Homo sapiens Human  Hsap\ABCC1 Y
Human Orthologs (4)
Gene OMIM HGNC Hsap\ENSG00000108846     Hsap\ABCC4     Hsap\ABCC2     Hsap\ABCC1
AAA Orthologs (4) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD20097 Drosophila ananassae Dana\GF17354 Drosophila pseudoobscura pseudoobscura Dpse\GA18260 Drosophila willistoni Dwil\GK22360
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	16948 y1 w67c23; P{EPgy2}CG4562EY09703 32842 y1 sc* v1; P{TRiP.HMS00623}attP2
Harvard	- PBac{PB}CG4562c02418 - PBac{WH}CG4562f01067
VDRC	v106975 P{KK100405}VIE-260B v6770 w1118; P{GD3073}v6770/CyO
Genomic Clones ( 2 )
	BACR02O09 BACR48D03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 19 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LP18549
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE17943 RE21286 RE60344 RE74004
Other clones	122881 CK01340 RM02615 RM02715 RM02815 RM02915 RM03015 RM03115 RM03215 RM03315 RP001018817 RP001021652 RP001030544 RP001056522
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0038740 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42362
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_142581 NM_001104371 NM_001275816 NM_001275817 NM_001275818 RefSeq (Proteins) • NP_650838 NP_001097841 NP_001262745 NP_001262746 NP_001262747 DDBJ / EMBL / GenBank • AAF55707 AAX33500 ABW08706 AGB96125 AGB96126 AGB96127 BI215079 BT021352 CZ467928 CZ483553 CZ483554 Entrez Gene - A searchable database of RefSeq genes. • 42362 UniProtKB/TrEMBL • Q5BI72 Q9VDT3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • ABC transporter, transmembrane domain (IPR001140) ABC transporter-like (IPR003439) AAA+ ATPase domain (IPR003593) ABC transporter, transmembrane domain, type 1 (IPR011527) P-loop containing nucleoside triphosphate hydrolase (IPR027417) ABC transporter, conserved site (IPR017871) ABC transporter, integral membrane type 1 (IPR017940)
Linkouts
	BioGRID - A database of protein and genetic interactions • 67352 DroID - A comprehensive database of gene and protein interactions. • FBgn0038740 DRSC - Results from RNAi screens. • FBgn0038740 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0038740 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4562-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0038740 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42362 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42362 modMine - Data generated by the modENCODE project. • FBgn0038740
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	CG4562 (Ellis and Carney, 2009, Jungreis et al., 2011, Mayer et al., 2009, Keleman et al., 2009.8.5, Ni et al., 2010.12.1, Wasbrough et al., 2010, Shah et al., 2012, Japanese National Institute of Genetics, 2012.5.21) CT14766 (Ceriani et al., 2002) Dme_CG4562 (Tarnay et al., 2004)
Name Synonym
Secondary FlyBase IDs
References ( 24 )
Generate a list of	All references relating to this gene ( 24 )
List References by type	Research paper  ( 5 ) Supplementary material  ( 6 ) Review  ( 1 ) Personal communication to FlyBase  ( 7 ) FlyBase analysis  ( 1 ) Stock list  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 1 )
	Shah et al., 2012, Pest Manag. Sci. 68(1): 38--48 Insecticide detoxification indicator strains as tools for enhancing chemical discovery screens. [FBrf0217053] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...