FB2020_06, released Dec 22, 2020

Gene: Dmel\CG4562

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General Information
Symbol
Dmel\CG4562
Species
D. melanogaster
Name
Annotation Symbol
CG4562
Feature Type
protein_coding_gene
FlyBase ID
FBgn0038740
Gene Model Status
Current
Stock Availability
8 publicly available
Gene Snapshot
Contributions welcome
Other Summaries
Key Links
Genomic Location
Cytogenetic map
92B4-92B4
Sequence location
3R:19,865,417..19,875,678 [-]
Recombination map

3-67

RefSeq locus
NT_033777 REGION:19865417..19875678
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (6 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables ATP binding
inferred from electronic annotation with InterPro:IPR003439, InterPro:IPR011527, InterPro:IPR017871
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables ATPase activity
inferred from electronic annotation with InterPro:IPR003439, InterPro:IPR017871
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables ATPase-coupled transmembrane transporter activity
inferred from biological aspect of ancestor with PANTHER:PTN000657997
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in transmembrane transport
inferred from biological aspect of ancestor with PANTHER:PTN000657997
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in integral component of membrane
inferred from electronic annotation with InterPro:IPR011527, InterPro:IPR036640
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
located_in membrane
inferred from biological aspect of ancestor with PANTHER:PTN000657997
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
ABCC ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY -
The ATP-binding cassette (ABC) transporter family are primary active transporters that use ATP hydrolysis to drive the transport of substrates across the membrane. The ABCC subfamily are full transporters, encoding the functional transporter in one polypeptide. In humans some members of this class are associated with multidrug resistance. (Adapted from FBrf0224053).
Gene Model and Products
Number of Transcripts
5
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\CG4562 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

gene_with_stop_codon_read_through ; SO:0000697

Gene model reviewed during 5.44

Stop-codon suppression (UGA) postulated; FBrf0216884.

Gene model reviewed during 5.47

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Sequence Ontology: Class of Gene
gene_with_stop_codon_read_through
(Jungreis et al., 2011)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
CG4562-RA
FBtr0083859
NM_142581
4825
1362
CG4562-RB
FBtr0113250
NM_001104371
4539
948
CG4562-RC
FBtr0330034
NM_001275816
6512
1362
CG4562-RD
FBtr0330035
NM_001275817
4764
948
CG4562-RE
FBtr0330036
NM_001275818
4825
1408
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
CG4562-PA
FBpp0083268
152.8
1362
9.11
NP_650838
AAF55707
CG4562-PB
FBpp0112162
106.8
948
9.94
NP_001097841
ABW08706
CG4562-PC
FBpp0303067
152.8
1362
9.11
NP_001262745
AGB96125
CG4562-PD
FBpp0303068
106.8
948
9.94
NP_001262746
AGB96126
CG4562-PE
FBpp0303069
157.8
1408
9.25
NP_001262747
AGB96127
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1362 aa isoforms: CG4562-PA, CG4562-PC
948 aa isoforms: CG4562-PB, CG4562-PD
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG4562 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 5 of adulthood & male -- day 7 of adulthood & male
spermatozoon
(Wasbrough et al., 2010)
adult stage
adult head
• membrane
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CG4562 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 5 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of CG4562
Transgenic constructs containing regulatory region of CG4562
Deletions and Duplications ( 0 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal - all die during larval stage, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (20)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ABCC4
14 of 15
Yes
Yes
1  
Hsap\ABCC1
5 of 15
No
No
1  
Hsap\ABCC2
5 of 15
No
No
Hsap\ABCC3
5 of 15
No
No
Hsap\ABCC5
5 of 15
No
No
1  
Hsap\ABCC6
5 of 15
No
No
Hsap\ABCC8
5 of 15
No
No
Hsap\ABCC9
5 of 15
No
No
Hsap\ABCC10
5 of 15
No
No
Hsap\ABCC11
5 of 15
No
No
Hsap\ABCC12
5 of 15
No
No
Hsap\CFTR
5 of 15
No
Yes
10  
Hsap\ABCB4
1 of 15
No
No
Hsap\ABCB5
1 of 15
No
No
Hsap\ABCB8
1 of 15
No
No
Hsap\ABCB10
1 of 15
No
No
Hsap\ABCB11
1 of 15
No
No
Hsap\ARG1
1 of 15
No
No
Hsap\TAP1
1 of 15
No
No
Hsap\TAP2
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (22)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Abcc4
14 of 15
Yes
Yes
Mmus\Abcc1
5 of 15
No
No
Mmus\Abcc3
5 of 15
No
No
Mmus\Abcc5
5 of 15
No
No
Mmus\Abcc6
5 of 15
No
No
Mmus\Abcc8
5 of 15
No
No
Mmus\Abcc10
5 of 15
No
No
Mmus\Abcc12
5 of 15
No
No
Mmus\Cftr
5 of 15
No
Yes
Mmus\Abcc2
4 of 15
No
No
Mmus\Abcc9
4 of 15
No
No
Mmus\Abcb1a
1 of 15
No
No
Mmus\Abcb1b
1 of 15
No
No
Mmus\Abcb4
1 of 15
No
No
Mmus\Abcb5
1 of 15
No
No
Mmus\Abcb8
1 of 15
No
No
Mmus\Abcb9
1 of 15
No
Yes
Mmus\Abcb10
1 of 15
No
No
Mmus\Abcb11
1 of 15
No
No
Mmus\Gm10768
1 of 15
No
Yes
Mmus\Tap1
1 of 15
No
No
Mmus\Tap2
1 of 15
No
No
Rattus norvegicus (Norway rat) (24)
Rnor\Abcc4
8 of 13
Yes
Yes
Rnor\Abcc3
5 of 13
No
No
Rnor\Abcc5
5 of 13
No
Yes
Rnor\Abcc6
5 of 13
No
No
Rnor\Abcc9
5 of 13
No
No
Rnor\Abcc10
5 of 13
No
No
Rnor\Abcc12
5 of 13
No
Yes
Rnor\Abcc1
4 of 13
No
No
Rnor\Abcc2
4 of 13
No
No
Rnor\Abcc8
4 of 13
No
No
Rnor\Cftr
4 of 13
No
Yes
Rnor\Abcb1a
1 of 13
No
No
Rnor\Abcb1b
1 of 13
No
No
Rnor\Abcb4
1 of 13
No
No
Rnor\Abcb5
1 of 13
No
No
Rnor\Abcb9
1 of 13
No
No
Rnor\Abcb10
1 of 13
No
No
Rnor\Abcb11
1 of 13
No
No
Rnor\LOC688708
1 of 13
No
Yes
Rnor\LOC100912948
1 of 13
No
Yes
Rnor\LOC102550577
1 of 13
No
Yes
Rnor\LOC103689996
1 of 13
No
No
Rnor\Tap1
1 of 13
No
No
Rnor\Tap2
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (17)
Xtro\abcc4
7 of 12
Yes
Yes
Xtro\abcc3
4 of 12
No
No
Xtro\abcc6
4 of 12
No
No
Xtro\abcc10
4 of 12
No
No
Xtro\cftr
4 of 12
No
Yes
Xtro\abcc1
2 of 12
No
No
Xtro\abcc2
2 of 12
No
Yes
Xtro\abcc5
2 of 12
No
Yes
Xtro\abcc12
2 of 12
No
Yes
Xtro\LOC100486877
2 of 12
No
Yes
Xtro\LOC100493583
2 of 12
No
Yes
Xtro\LOC101730668
2 of 12
No
Yes
Xtro\LOC101733439
2 of 12
No
No
Xtro\abcb8
1 of 12
No
No
Xtro\LOC100494740
1 of 12
No
No
Xtro\tap1
1 of 12
No
No
Xtro\tap2
1 of 12
No
No
Danio rerio (Zebrafish) (27)
Drer\abcc4
9 of 15
Yes
Yes
Drer\abcc1
5 of 15
No
No
Drer\abcc2
5 of 15
No
No
Drer\abcc5
5 of 15
No
Yes
Drer\abcc6a
5 of 15
No
No
Drer\abcc8b
5 of 15
No
Yes
Drer\abcc9
5 of 15
No
No
Drer\abcc10
5 of 15
No
No
Drer\abcc12
5 of 15
No
No
Drer\cftr
5 of 15
No
Yes
Drer\abcc6b.2
4 of 15
No
No
Drer\abcc8
4 of 15
No
No
Drer\abcc13
4 of 15
No
Yes
Drer\abcc3
3 of 15
No
No
Drer\wu:fb13g09
3 of 15
No
Yes
Drer\abcc6b.1
2 of 15
No
No
Drer\abcb4
1 of 15
No
No
Drer\abcb5
1 of 15
No
No
Drer\abcb8
1 of 15
No
No
Drer\abcb9
1 of 15
No
No
Drer\abcb10
1 of 15
No
No
Drer\abcb11a
1 of 15
No
No
Drer\abcb11b
1 of 15
No
No
Drer\LOC110439293
1 of 15
No
No
Drer\tap1
1 of 15
No
No
Drer\tap2a
1 of 15
No
No
Drer\tap2t
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (29)
Cele\mrp-6
8 of 15
Yes
No
Cele\mrp-1
4 of 15
No
No
Cele\mrp-2
4 of 15
No
No
Cele\mrp-3
4 of 15
No
No
Cele\mrp-4
4 of 15
No
No
Cele\mrp-5
4 of 15
No
No
Cele\mrp-7
4 of 15
No
No
Cele\mrp-8
4 of 15
No
No
Cele\cft-1
3 of 15
No
No
Cele\haf-1
1 of 15
No
No
Cele\haf-2
1 of 15
No
No
Cele\haf-3
1 of 15
No
No
Cele\haf-4
1 of 15
No
No
Cele\haf-6
1 of 15
No
No
Cele\haf-7
1 of 15
No
No
Cele\haf-8
1 of 15
No
No
Cele\pgp-1
1 of 15
No
No
Cele\pgp-2
1 of 15
No
No
Cele\pgp-4
1 of 15
No
No
Cele\pgp-5
1 of 15
No
No
Cele\pgp-6
1 of 15
No
No
Cele\pgp-7
1 of 15
No
No
Cele\pgp-8
1 of 15
No
No
Cele\pgp-9
1 of 15
No
No
Cele\pgp-10
1 of 15
No
No
Cele\pgp-11
1 of 15
No
No
Cele\pgp-12
1 of 15
No
No
Cele\pgp-13
1 of 15
No
No
Cele\pgp-14
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (20)
Atha\ABCC3
4 of 9
Yes
No
Atha\ABCC4
4 of 9
Yes
Yes
Atha\ABCC6
4 of 9
Yes
No
Atha\ABCC7
4 of 9
Yes
Yes
Atha\ABCC14
4 of 9
Yes
Yes
Atha\ABCC1
3 of 9
No
No
Atha\ABCC2
3 of 9
No
No
Atha\ABCC5
3 of 9
No
Yes
Atha\ABCC8
3 of 9
No
No
Atha\ABCC9
3 of 9
No
Yes
Atha\ABCC10
3 of 9
No
Yes
Atha\ABCC15
3 of 9
No
No
Atha\ABCC11
2 of 9
No
No
Atha\ABCC12
2 of 9
No
No
Atha\ABCC13
2 of 9
No
No
Atha\ABCG33
1 of 9
No
Yes
Atha\ABCG37
1 of 9
No
Yes
Atha\ABCG41
1 of 9
No
Yes
Atha\ABCG43
1 of 9
No
Yes
Atha\NAP5
1 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (10)
Scer\YBT1
6 of 15
Yes
Yes
Scer\VMR1
5 of 15
No
Yes
Scer\BPT1
4 of 15
No
No
Scer\NFT1
4 of 15
No
No
Scer\YOR1
4 of 15
No
No
Scer\YCF1
3 of 15
No
No
Scer\YKR104W
3 of 15
No
No
Scer\STE6
2 of 15
No
No
1  
Scer\MDL1
1 of 15
No
No
Scer\MDL2
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (4)
Spom\abc4
3 of 12
Yes
No
Spom\ybt1
3 of 12
Yes
Yes
Spom\abc2
2 of 12
No
No
Spom\abc3
2 of 12
No
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091900OC )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila simulans
Dsim\GD20097
Drosophila sechellia
Dsec\GM26890
Drosophila erecta
Dere\GG15808
Drosophila yakuba
Dyak\GE25109
Drosophila willistoni
Dwil\GK22360
Drosophila grimshawi
Dgri\GH23331
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500H3 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17008620
Musca domestica
House fly
Mdoa\17025036
Musca domestica
House fly
Mdoa\17010600
Musca domestica
House fly
Mdoa\17025039
Musca domestica
House fly
Mdoa\17007546
Musca domestica
House fly
Mdoa\17011900
Musca domestica
House fly
Mdoa\17007545
Musca domestica
House fly
Mdoa\17010601
Musca domestica
House fly
Mdoa\17010739
Glossina morsitans
Tsetse fly
Gmor\GMOY003900
Glossina morsitans
Tsetse fly
Gmor\GMOY009859
Glossina morsitans
Tsetse fly
Gmor\GMOY006234
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_11737
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_06545
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_01726
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_06632
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_11094
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_11095
Mayetiola destructor
Hessian fly
Mdes\Mdes002100
Mayetiola destructor
Hessian fly
Mdes\Mdes001987
Mayetiola destructor
Hessian fly
Mdes\Mdes002094
Mayetiola destructor
Hessian fly
Mdes\Mdes007300
Mayetiola destructor
Hessian fly
Mdes\Mdes000581
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL013834
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL012395
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL005918
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL013567
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL018267
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL005937
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL012386
Anopheles darlingi
American malaria mosquito
Adar\ADAC010113
Anopheles darlingi
American malaria mosquito
Adar\ADAC010688
Anopheles darlingi
American malaria mosquito
Adar\ADAC003507
Anopheles darlingi
American malaria mosquito
Adar\ADAC010108
Anopheles darlingi
American malaria mosquito
Adar\ADAC010689
Anopheles gambiae
Malaria mosquito
Agam\AGAP006427
Anopheles gambiae
Malaria mosquito
Agam\AGAP004603
Anopheles gambiae
Malaria mosquito
Agam\AGAP001775
Anopheles gambiae
Malaria mosquito
Agam\AGAP001777
Anopheles gambiae
Malaria mosquito
Agam\AGAP004602
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ008281
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ011652
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ004604
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ016918
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ008283
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ001310
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W00X0 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA007735
Bombyx mori
Silkmoth
Bmor\BGIBMGA010330
Bombyx mori
Silkmoth
Bmor\BGIBMGA011220
Bombyx mori
Silkmoth
Bmor\BGIBMGA007738
Bombyx mori
Silkmoth
Bmor\BGIBMGA010332
Bombyx mori
Silkmoth
Bmor\BGIBMGA010849
Bombyx mori
Silkmoth
Bmor\BGIBMGA003359
Danaus plexippus
Monarch butterfly
Dple\DPOGS208713-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS208066-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS208634-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS208494-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS208084-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS208065-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS203074-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS202687-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL008762
Heliconius melpomene
Postman butterfly
Hmel\HMEL015261
Heliconius melpomene
Postman butterfly
Hmel\HMEL003355
Heliconius melpomene
Postman butterfly
Hmel\HMEL011589
Heliconius melpomene
Postman butterfly
Hmel\HMEL003354
Heliconius melpomene
Postman butterfly
Hmel\HMEL011731
Heliconius melpomene
Postman butterfly
Hmel\HMEL003351
Heliconius melpomene
Postman butterfly
Hmel\HMEL014185
Apis florea
Little honeybee
Aflo\2214844468
Apis florea
Little honeybee
Aflo\2589023892
Apis florea
Little honeybee
Aflo\2315419124
Apis florea
Little honeybee
Aflo\2155303284
Apis florea
Little honeybee
Aflo\2379350372
Apis mellifera
Western honey bee
Amel\GB43189
Apis mellifera
Western honey bee
Amel\LOC551061
Apis mellifera
Western honey bee
Amel\GB53134
Apis mellifera
Western honey bee
Amel\GB48573
Apis mellifera
Western honey bee
Amel\GB50195
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP18350
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP21252
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP22500
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP14830
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP21060
Bombus terrestris
Buff-tailed bumblebee
Bter\15205612
Bombus terrestris
Buff-tailed bumblebee
Bter\15215779
Bombus terrestris
Buff-tailed bumblebee
Bter\15212604
Bombus terrestris
Buff-tailed bumblebee
Bter\15211279
Bombus terrestris
Buff-tailed bumblebee
Bter\15211632
Linepithema humile
Argentine ant
Lhum\LH25761
Linepithema humile
Argentine ant
Lhum\LH22562
Linepithema humile
Argentine ant
Lhum\LH12079
Linepithema humile
Argentine ant
Lhum\LH15915
Linepithema humile
Argentine ant
Lhum\LH22565
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000168
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0000ee
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00011e
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00205d
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002038
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG005769
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG014001
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG007473
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG005619
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG011110
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG005949
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG008391
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG005944
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG005771
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG001436
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG022099
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG001435
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG005946
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG001437
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_04278
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_03598
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_05102
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_03994
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_08194
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_06255
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_08305
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_06244
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02982
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_03090
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_07647
Tribolium castaneum
Red flour beetle
Tcas\TC013751
Tribolium castaneum
Red flour beetle
Tcas\TC014092
Tribolium castaneum
Red flour beetle
Tcas\TC009892
Tribolium castaneum
Red flour beetle
Tcas\TC014383
Tribolium castaneum
Red flour beetle
Tcas\TC009891
Tribolium castaneum
Red flour beetle
Tcas\TC014089
Tribolium castaneum
Red flour beetle
Tcas\TC014589
Tribolium castaneum
Red flour beetle
Tcas\TC014775
Tribolium castaneum
Red flour beetle
Tcas\TC013750
Tribolium castaneum
Red flour beetle
Tcas\TC014403
Tribolium castaneum
Red flour beetle
Tcas\TC014090
Tribolium castaneum
Red flour beetle
Tcas\TC033612
Tribolium castaneum
Red flour beetle
Tcas\TC010434
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_15346
Tribolium castaneum
Red flour beetle
Tcas\TC033390
Tribolium castaneum
Red flour beetle
Tcas\TC014091
Tribolium castaneum
Red flour beetle
Tcas\TC008570
Tribolium castaneum
Red flour beetle
Tcas\TC014776
Tribolium castaneum
Red flour beetle
Tcas\TC012253
Tribolium castaneum
Red flour beetle
Tcas\TC034098
Tribolium castaneum
Red flour beetle
Tcas\TC013749
Tribolium castaneum
Red flour beetle
Tcas\TC013752
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_14880
Tribolium castaneum
Red flour beetle
Tcas\TC010962
Pediculus humanus
Human body louse
Phum\PHUM075990
Pediculus humanus
Human body louse
Phum\PHUM351610
Pediculus humanus
Human body louse
Phum\PHUM513390
Rhodnius prolixus
Kissing bug
Rpro\RPRC008610
Rhodnius prolixus
Kissing bug
Rpro\RPRC014278
Cimex lectularius
Bed bug
Clec\CLEC025140
Cimex lectularius
Bed bug
Clec\CLEC011933
Cimex lectularius
Bed bug
Clec\CLEC006400
Cimex lectularius
Bed bug
Clec\CLEC011936
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI23911
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI38602
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI004675
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI084147
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI068671
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI008842
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI006979
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI070177
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI007210
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI000359
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI002363
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI008595
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI084024
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI005339
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI006442
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI001507
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI004533
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI006066
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI001390
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_01907
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_11998
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_01434
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_09464
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_02081
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_09949
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_02052
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_09948
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0183 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR008549
Strigamia maritima
European centipede
Smar\SMAR006496
Strigamia maritima
European centipede
Smar\SMAR008548
Strigamia maritima
European centipede
Smar\SMAR006498
Strigamia maritima
European centipede
Smar\SMAR011036
Strigamia maritima
European centipede
Smar\SMAR011133
Strigamia maritima
European centipede
Smar\SMAR011077
Strigamia maritima
European centipede
Smar\SMAR005358
Ixodes scapularis
Black-legged tick
Isca\ISCW007915
Ixodes scapularis
Black-legged tick
Isca\ISCW021900
Ixodes scapularis
Black-legged tick
Isca\ISCW018516
Ixodes scapularis
Black-legged tick
Isca\ISCW019069
Stegodyphus mimosarum
African social velvet spider
Smim\KFM57967.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM75623.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM82636.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM80877.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur16g03480
Tetranychus urticae
Two-spotted spider mite
Turt\tetur09g04610
Tetranychus urticae
Two-spotted spider mite
Turt\tetur14g02300
Tetranychus urticae
Two-spotted spider mite
Turt\tetur14g02310
Tetranychus urticae
Two-spotted spider mite
Turt\tetur07g04410
Tetranychus urticae
Two-spotted spider mite
Turt\tetur05g01110
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g07860
Tetranychus urticae
Two-spotted spider mite
Turt\tetur11g02060
Tetranychus urticae
Two-spotted spider mite
Turt\tetur14g02290
Tetranychus urticae
Two-spotted spider mite
Turt\tetur28g01950
Tetranychus urticae
Two-spotted spider mite
Turt\tetur09g00590
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g05540
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g15310
Tetranychus urticae
Two-spotted spider mite
Turt\tetur14g02330
Tetranychus urticae
Two-spotted spider mite
Turt\tetur06g00280
Tetranychus urticae
Two-spotted spider mite
Turt\tetur09g00580
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g07910
Tetranychus urticae
Two-spotted spider mite
Turt\tetur03g09880
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g10390
Tetranychus urticae
Two-spotted spider mite
Turt\tetur14g02320
Tetranychus urticae
Two-spotted spider mite
Turt\tetur03g02240
Tetranychus urticae
Two-spotted spider mite
Turt\tetur40g00010
Tetranychus urticae
Two-spotted spider mite
Turt\tetur06g00220
Tetranychus urticae
Two-spotted spider mite
Turt\tetur23g02452
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g07880
Tetranychus urticae
Two-spotted spider mite
Turt\tetur03g07490
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g04360
Tetranychus urticae
Two-spotted spider mite
Turt\tetur06g03510
Tetranychus urticae
Two-spotted spider mite
Turt\tetur25g01780
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g15340
Tetranychus urticae
Two-spotted spider mite
Turt\tetur06g00360
Tetranychus urticae
Two-spotted spider mite
Turt\tetur09g04620
Tetranychus urticae
Two-spotted spider mite
Turt\tetur11g02120
Tetranychus urticae
Two-spotted spider mite
Turt\tetur03g09800
Tetranychus urticae
Two-spotted spider mite
Turt\tetur07g04290
Tetranychus urticae
Two-spotted spider mite
Turt\tetur05g04300
Tetranychus urticae
Two-spotted spider mite
Turt\tetur06g03560
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g15330
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_347288
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_347281
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G00IN )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc4e
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc9e
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Mrpl
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc3a
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc9k
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc9f
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc9i
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc9c
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc9h
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Sur1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc9b
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc4b
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc10a
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc10
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc4d
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_015053gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc9j
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-ABCC9g
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc8
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc4a
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc9l
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc9a
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc4c
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc1b
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc10b
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc9_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Abcc9d
Ciona intestinalis
Vase tunicate
Cint\LOC100185468
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000006107
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000007551
Gallus gallus
Domestic chicken
Ggal\ABCC4
Gallus gallus
Domestic chicken
Ggal\LOC416599
Gallus gallus
Domestic chicken
Ggal\ABCC9
Gallus gallus
Domestic chicken
Ggal\ABCC2
Gallus gallus
Domestic chicken
Ggal\ABCC3
Gallus gallus
Domestic chicken
Ggal\ABCC10
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000015675
Gallus gallus
Domestic chicken
Ggal\ABCC1
Gallus gallus
Domestic chicken
Ggal\ABCC8
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (19)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG7627
9 of 10
CG9270
8 of 10
CG31792
8 of 10
CG31793
8 of 10
l(2)03659
7 of 10
Mrp4
7 of 10
CG10505
6 of 10
CG11898
6 of 10
MRP
6 of 10
rdog
6 of 10
Cftr
5 of 10
CG7806
5 of 10
Sur
4 of 10
CG1824
1 of 10
CG3156
1 of 10
CG10226
1 of 10
Mdr49
1 of 10
Mdr50
1 of 10
Mdr65
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 5 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ABCC4; ATP binding cassette subfamily C member 4
    14 of 15
    605250
         
        ABCC1; ATP binding cassette subfamily C member 1
        5 of 15
        158343
           
          ABCC2; ATP binding cassette subfamily C member 2
          5 of 15
          601107
          ABCC3; ATP binding cassette subfamily C member 3
          5 of 15
          604323
              ABCC5; ATP binding cassette subfamily C member 5
              5 of 15
              605251
                   
                  ABCC6; ATP binding cassette subfamily C member 6
                  5 of 15
                  603234
                  ABCC8; ATP binding cassette subfamily C member 8
                  5 of 15
                  600509
                  ABCC9; ATP binding cassette subfamily C member 9
                  5 of 15
                  601439
                  ABCC10; ATP binding cassette subfamily C member 10
                  5 of 15
                  612509
                      ABCC11; ATP binding cassette subfamily C member 11
                      5 of 15
                      607040
                        ABCC12; ATP binding cassette subfamily C member 12
                        5 of 15
                        607041
                            CFTR; CF transmembrane conductance regulator
                            5 of 15
                            602421
                             
                            Functional Complementation Data
                            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                            Interactions
                            Summary of Physical Interactions
                            esyN Network Diagram
                            Interactions Browser
                            Summary of Genetic Interactions
                            esyN Network Diagram
                            esyN Network Key:
                            Suppression
                            Enhancement
                            View in Interactions Browser
                            Please look at the allele data for full details of the genetic interactions
                            Starting gene(s)
                            Interaction type
                            Interacting gene(s)
                            Reference
                            Starting gene(s)
                            Interaction type
                            Interacting gene(s)
                            Reference
                            DCTN1-p150
                            enhanceable
                            CG4562
                            (Chang et al., 2013)
                            External Data
                            Linkouts
                            BioGRID - A database of protein and genetic interactions.
                            DroID - A comprehensive database of gene and protein interactions.
                            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                            MIST (protein-protein) - An integrated Molecular Interaction Database
                            Pathways
                            Signaling Pathways (FlyBase)
                            Metabolic Pathways
                            External Data
                            Linkouts
                            KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                            Genomic Location and Detailed Mapping Data
                            Chromosome (arm)
                            3R
                            Recombination map

                            3-67

                            Cytogenetic map
                            92B4-92B4
                            Sequence location
                            3R:19,865,417..19,875,678 [-]
                            FlyBase Computed Cytological Location
                            Cytogenetic map
                            Evidence for location
                            92B4-92B4
                            Limits computationally determined from genome sequence between P{PZ}l(3)1058510585 and P{EP}SyndEP409
                            Experimentally Determined Cytological Location
                            Cytogenetic map
                            Notes
                            References
                            Experimentally Determined Recombination Data
                            Location

                            3-67

                            (FlyBase, 2016)

                            3-69.4

                            (Comeron et al., 2012)
                            Left of (cM)
                            Right of (cM)
                            Notes
                            Stocks and Reagents
                            Stocks (8)
                            Genomic Clones (12)
                             

                            Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                            cDNA Clones (19)
                             

                            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                            cDNA clones, fully sequenced
                            BDGP DGC clones
                            Other clones
                              Drosophila Genomics Resource Center cDNA clones

                              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                              cDNA Clones, End Sequenced (ESTs)
                              BDGP DGC clones
                              Other clones
                              RNAi and Array Information
                              Linkouts
                              DRSC - Results frm RNAi screens
                              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                              Antibody Information
                              Laboratory Generated Antibodies
                               
                              Commercially Available Antibodies
                               
                              Other Information
                              Relationship to Other Genes
                              Source for database identify of
                              Source for database merge of
                              Additional comments
                              Other Comments
                              Origin and Etymology
                              Discoverer
                              Etymology
                              Identification
                              External Crossreferences and Linkouts ( 51 )
                              Sequence Crossreferences
                              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                              Other crossreferences
                              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                              Flygut - An atlas of the Drosophila adult midgut
                              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                              InterPro - A database of protein families, domains and functional sites
                              KEGG Genes - Molecular building blocks of life in the genomic space.
                              modMine - A data warehouse for the modENCODE project
                              Linkouts
                              BioGRID - A database of protein and genetic interactions.
                              DroID - A comprehensive database of gene and protein interactions.
                              DRSC - Results frm RNAi screens
                              FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                              FlyMine - An integrated database for Drosophila genomics
                              InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                              KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                              MIST (protein-protein) - An integrated Molecular Interaction Database
                              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                              Synonyms and Secondary IDs (4)
                              Datasets (0)
                              Study focus (0)
                              Experimental Role
                              Project
                              Project Type
                              Title
                              References (41)