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Gene Dmel\Hs6st

General Information
Symbol	Dmel\Hs6st	Species	D. melanogaster
Name	Heparan sulfate 6-O-sulfotransferase	Annotation symbol	CG4451
Feature type	protein_coding_gene	FlyBase ID	FBgn0038755
Gene Model Status	Current	Stock availability	10 publicly available
Also Known As	dHS6ST
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	92B9-92C1	Sequence location	3R:15,755,436..15,834,244 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Heparan sulfate 6-O-sulfotransferase is referred to in FlyBase by the symbol Dmel\Hs6st (CG4451, FBgn0038755). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: heparan sulfate 6-O-sulfotransferase activity. There is experimental evidence that it is involved in the biological process: open tracheal system development. 22 alleles are reported. The phenotypes of these alleles are annotated with: embryonic/larval lateral trunk; eye; embryonic/larval trachea; embryonic/larval dorsal trunk; presumptive embryonic/larval tracheal system; embryonic/larval tracheal system; imaginal tracheoblast; embryonic/larval dorsal branch. It has one annotated transcript and one annotated polypeptide. Protein features are: Heparan sulphate 6-sulfotransferase; Sulfotransferase. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval trachea. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, larval Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, adult female reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1636347_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Hs6st. Gene sequence location is 3R:15755436..15834244.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References Nishihara, 2010, Methods Enzymol. 480C: 323--351 Sequence features BKN21687 HFA15581 HFA15182 HFA14348
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 92B9-92C1   Limits computationally determined from genome sequence between P{PZ}l(3)1058510585 and P{EP}SyndEP409
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Hs6st for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Hs6st-RA FBtr0083846  NM_079685   2673   462
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Hs6st-PA   FBpp0083255   52.7   462   8.12     NP_524409   AAF55724
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Heparan sulphate 6-sulfotransferase (IPR010635) Sulfotransferase (IPR005331)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201926   AA202957   AA392075   AA392241   AA536560   AA539923   AE014297 AAF55724   AB051856 BAB55594   AI260750   AI455028   AI519539   AW943455   AY051902 AAK93326   BI163252   BI170754   BI172651   BI213914   BI215682   BI240732   BI241567   BI242705   BI243845   BI362020   BI363681   BI369900   BI373811   BI373929   BI374342   BI481824   BI484141   BI608045   BI621408   BI628142   BI630526   BP550949   CK660724   CL528164   CO177968   CO177976   CO189168   CO272332   CO289871   CO293531   CO302625   CO309553   CO332624   CO343453   CZ468161   CZ468162   CZ470540   CZ481859   CZ484413   CZ484414   CZ485099   CZ487539   CZ487967   CZ488520   CZ488521   DN154472   EC058287   EC061049   EC081123   EC195404   EC206668   EC220150   EC224271   EC230657   EC231213   EC232344   EC234806   EC240999   EC242645   EC246297   EC256167   GH738944   GH766385
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q968Z7 Q9VDR6
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 3 -- 4   organism | ubiquitous   (Kamimura et al., 2001) Comment:maternally supplied embryonic stage 6 -- 8   organism | ubiquitous   (Kamimura et al., 2001) mesoderm   (Kamimura et al., 2001) embryonic stage 10 -- 11   tracheal pit   (Kamimura et al., 2001) embryonic stage 16   organism | ubiquitous   (Kamimura et al., 2001) third instar larval stage   wing disc | ubiquitous   (Kamimura et al., 2001) eye disc anterior to the morphogenetic furrow   (Kamimura et al., 2001) lobula   (Kamimura et al., 2001) larval outer optic anlage   (Kamimura et al., 2001)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0038755    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0038755 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages, at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0038755 expression level Developmental Stage   Expression Level embryo 00-02hr    1714 embryo 02-04hr    1796 embryo 04-06hr    1165 embryo 06-08hr    1410 embryo 08-10hr    1630 embryo 10-12hr    1711 embryo 12-14hr    1864 embryo 14-16hr    1820 embryo 16-18hr    1503 embryo 18-20hr    900 embryo 20-22hr    1099 embryo 22-24hr    1360 larva L1    724 larva L2    554 larva L3 12hr old    507 larva L3 puffstage 1-2    513 larva L3 puffstage 3-6    779 larva L3 puffstage 7-9    957 white prepupae new    1034 white prepupae 12hr    1524 white prepupae 24hr    1770 pupae 2d postWPP    1807 pupae 3d postWPP    854 pupae 4d postWPP    396 adult male 01day    390 adult male 05day    411 adult male 30day    429 adult female 01day    538 adult female 05day    822 adult female 30day    909 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1714) embryo 02-04hr  (1796) embryo 04-06hr  (1165) embryo 06-08hr  (1410) embryo 08-10hr  (1630) embryo 10-12hr  (1711) embryo 12-14hr  (1864) embryo 14-16hr  (1820) embryo 16-18hr  (1503) embryo 18-20hr  (900) embryo 20-22hr  (1099) embryo 22-24hr  (1360) larva L1  (724) larva L2  (554) larva L3 12hr old  (507) larva L3 puffstage 1-2  (513) larva L3 puffstage 3-6  (779) larva L3 puffstage 7-9  (957) white prepupae new  (1034) white prepupae 12hr  (1524) white prepupae 24hr  (1770) pupae 2d postWPP  (1807) pupae 3d postWPP  (854) pupae 4d postWPP  (396) adult male 01day  (390) adult male 05day  (411) adult male 30day  (429) adult female 01day  (538) adult female 05day  (822) adult female 30day  (909) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (1714) embryo 02-04hr  (1796) embryo 04-06hr    1165 embryo 06-08hr  1410 embryo 08-10hr  (1630) embryo 10-12hr  (1711) embryo 12-14hr  (1864) embryo 14-16hr  (1820) embryo 16-18hr  1503 embryo 18-20hr    900 embryo 20-22hr    1099 embryo 22-24hr    1360 larva L1    724 larva L2    554 larva L3 12hr old    507 larva L3 puffstage 1-2    513 larva L3 puffstage 3-6    779 larva L3 puffstage 7-9    957 white prepupae new    1034 white prepupae 12hr  (1524) white prepupae 24hr  (1770) pupae 2d postWPP  (1807) pupae 3d postWPP    854 pupae 4d postWPP    396 adult male 01day    390 adult male 05day    411 adult male 30day    429 adult female 01day    538 adult female 05day    822 adult female 30day    909 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1714 embryo 02-04hr    1796 embryo 04-06hr    1165 embryo 06-08hr    1410 embryo 08-10hr    1630 embryo 10-12hr    1711 embryo 12-14hr    1864 embryo 14-16hr    1820 embryo 16-18hr    1503 embryo 18-20hr    900 embryo 20-22hr    1099 embryo 22-24hr    1360 larva L1    724 larva L2    554 larva L3 12hr old    507 larva L3 puffstage 1-2    513 larva L3 puffstage 3-6    779 larva L3 puffstage 7-9    957 white prepupae new    1034 white prepupae 12hr    1524 white prepupae 24hr    1770 pupae 2d postWPP    1807 pupae 3d postWPP    854 pupae 4d postWPP    396 adult male 01day    390 adult male 05day    411 adult male 30day    429 adult female 01day    538 adult female 05day    822 adult female 30day    909 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1714 embryo 02-04hr    1796 embryo 04-06hr    1165 embryo 06-08hr    1410 embryo 08-10hr    1630 embryo 10-12hr    1711 embryo 12-14hr    1864 embryo 14-16hr    1820 embryo 16-18hr    1503 embryo 18-20hr    900 embryo 20-22hr    1099 embryo 22-24hr    1360 larva L1    724 larva L2    554 larva L3 12hr old    507 larva L3 puffstage 1-2    513 larva L3 puffstage 3-6    779 larva L3 puffstage 7-9    957 white prepupae new    1034 white prepupae 12hr    1524 white prepupae 24hr    1770 pupae 2d postWPP    1807 pupae 3d postWPP    854 pupae 4d postWPP    396 adult male 01day    390 adult male 05day    411 adult male 30day    429 adult female 01day    538 adult female 05day    822 adult female 30day    909 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0038755 expression level Developmental Stage   Expression Level embryo 00-02hr    1714 embryo 02-04hr    1796 embryo 04-06hr    1165 embryo 06-08hr    1410 embryo 08-10hr    1630 embryo 10-12hr    1711 embryo 12-14hr    1864 embryo 14-16hr    1820 embryo 16-18hr    1503 embryo 18-20hr    900 embryo 20-22hr    1099 embryo 22-24hr    1360 larva L1    724 larva L2    554 larva L3 12hr old    507 larva L3 puffstage 1-2    513 larva L3 puffstage 3-6    779 larva L3 puffstage 7-9    957 white prepupae new    1034 white prepupae 12hr    1524 white prepupae 24hr    1770 pupae 2d postWPP    1807 pupae 3d postWPP    854 pupae 4d postWPP    396 adult male 01day    390 adult male 05day    411 adult male 30day    429 adult female 01day    538 adult female 05day    822 adult female 30day    909 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1714) embryo 02-04hr  (1796) embryo 04-06hr  (1165) embryo 06-08hr  (1410) embryo 08-10hr  (1630) embryo 10-12hr  (1711) embryo 12-14hr  (1864) embryo 14-16hr  (1820) embryo 16-18hr  (1503) embryo 18-20hr  (900) embryo 20-22hr  (1099) embryo 22-24hr  (1360) larva L1  (724) larva L2  (554) larva L3 12hr old  (507) larva L3 puffstage 1-2  (513) larva L3 puffstage 3-6  (779) larva L3 puffstage 7-9  (957) white prepupae new  (1034) white prepupae 12hr  (1524) white prepupae 24hr  (1770) pupae 2d postWPP  (1807) pupae 3d postWPP  (854) pupae 4d postWPP  (396) adult male 01day  (390) adult male 05day  (411) adult male 30day  (429) adult female 01day  (538) adult female 05day  (822) adult female 30day  (909) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  1714 embryo 02-04hr  1796 embryo 04-06hr    1165 embryo 06-08hr  1410 embryo 08-10hr  1630 embryo 10-12hr  1711 embryo 12-14hr  1864 embryo 14-16hr  1820 embryo 16-18hr  1503 embryo 18-20hr    900 embryo 20-22hr    1099 embryo 22-24hr    1360 larva L1    724 larva L2    554 larva L3 12hr old    507 larva L3 puffstage 1-2    513 larva L3 puffstage 3-6    779 larva L3 puffstage 7-9    957 white prepupae new    1034 white prepupae 12hr  1524 white prepupae 24hr  1770 pupae 2d postWPP  1807 pupae 3d postWPP    854 pupae 4d postWPP    396 adult male 01day    390 adult male 05day    411 adult male 30day    429 adult female 01day    538 adult female 05day    822 adult female 30day    909 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1714 embryo 02-04hr    1796 embryo 04-06hr    1165 embryo 06-08hr    1410 embryo 08-10hr    1630 embryo 10-12hr    1711 embryo 12-14hr    1864 embryo 14-16hr    1820 embryo 16-18hr    1503 embryo 18-20hr    900 embryo 20-22hr    1099 embryo 22-24hr    1360 larva L1    724 larva L2    554 larva L3 12hr old    507 larva L3 puffstage 1-2    513 larva L3 puffstage 3-6    779 larva L3 puffstage 7-9    957 white prepupae new    1034 white prepupae 12hr    1524 white prepupae 24hr    1770 pupae 2d postWPP    1807 pupae 3d postWPP    854 pupae 4d postWPP    396 adult male 01day    390 adult male 05day    411 adult male 30day    429 adult female 01day    538 adult female 05day    822 adult female 30day    909 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1714 embryo 02-04hr    1796 embryo 04-06hr    1165 embryo 06-08hr    1410 embryo 08-10hr    1630 embryo 10-12hr    1711 embryo 12-14hr    1864 embryo 14-16hr    1820 embryo 16-18hr    1503 embryo 18-20hr    900 embryo 20-22hr    1099 embryo 22-24hr    1360 larva L1    724 larva L2    554 larva L3 12hr old    507 larva L3 puffstage 1-2    513 larva L3 puffstage 3-6    779 larva L3 puffstage 7-9    957 white prepupae new    1034 white prepupae 12hr    1524 white prepupae 24hr    1770 pupae 2d postWPP    1807 pupae 3d postWPP    854 pupae 4d postWPP    396 adult male 01day    390 adult male 05day    411 adult male 30day    429 adult female 01day    538 adult female 05day    822 adult female 30day    909 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0038755    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0038755 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval trachea. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, larval Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, adult female reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0038755 expression level Tissue   Expression Level Larval Central Nervous System    269.9 Larval Midgut    52.2 Larval Hindgut    87 Larval Malpighian Tubules    325.9 Larval Fat Body    86.9 Larval Salivary Gland    107.5 Larval Trachea    810.425 Larval Carcass    139.7 Adult Head    88.6 Adult Eye    126.65 Adult Brain    166.3 Adult Thoracic-Abdominal Ganglion    177.6 Adult Crop    69.4 Adult Midgut    40 Adult Hindgut    57.6 Adult Malpighian Tubules    90.4 Adult Fat Body    180 Adult Salivary Gland    151.1 Adult Heart    151.275 Adult VirginFemale Spermatheca    149.3 Adult InseminatedFemale Spermatheca    141.7 Adult Ovary    195 Adult Testis    16.6 Adult Male Accessory Gland    57.2 Adult Carcass    108.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    269.9 Larval Midgut    52.2 Larval Hindgut    87 Larval Malpighian Tubules    325.9 Larval Fat Body    86.9 Larval Salivary Gland    107.5 Larval Trachea  (810.425) Larval Carcass    139.7 Adult Head    88.6 Adult Eye    126.65 Adult Brain    166.3 Adult Thoracic-Abdominal Ganglion    177.6 Adult Crop    69.4 Adult Midgut    40 Adult Hindgut    57.6 Adult Malpighian Tubules    90.4 Adult Fat Body    180 Adult Salivary Gland    151.1 Adult Heart    151.275 Adult VirginFemale Spermatheca    149.3 Adult InseminatedFemale Spermatheca    141.7 Adult Ovary    195 Adult Testis    16.6 Adult Male Accessory Gland    57.2 Adult Carcass    108.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    269.9 Larval Midgut    52.2 Larval Hindgut    87 Larval Malpighian Tubules    325.9 Larval Fat Body    86.9 Larval Salivary Gland    107.5 Larval Trachea    810.425 Larval Carcass    139.7 Adult Head    88.6 Adult Eye    126.65 Adult Brain    166.3 Adult Thoracic-Abdominal Ganglion    177.6 Adult Crop    69.4 Adult Midgut    40 Adult Hindgut    57.6 Adult Malpighian Tubules    90.4 Adult Fat Body    180 Adult Salivary Gland    151.1 Adult Heart    151.275 Adult VirginFemale Spermatheca    149.3 Adult InseminatedFemale Spermatheca    141.7 Adult Ovary    195 Adult Testis    16.6 Adult Male Accessory Gland    57.2 Adult Carcass    108.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    269.9 Larval Midgut    52.2 Larval Hindgut    87 Larval Malpighian Tubules    325.9 Larval Fat Body    86.9 Larval Salivary Gland    107.5 Larval Trachea    810.425 Larval Carcass    139.7 Adult Head    88.6 Adult Eye    126.65 Adult Brain    166.3 Adult Thoracic-Abdominal Ganglion    177.6 Adult Crop    69.4 Adult Midgut    40 Adult Hindgut    57.6 Adult Malpighian Tubules    90.4 Adult Fat Body    180 Adult Salivary Gland    151.1 Adult Heart    151.275 Adult VirginFemale Spermatheca    149.3 Adult InseminatedFemale Spermatheca    141.7 Adult Ovary    195 Adult Testis    16.6 Adult Male Accessory Gland    57.2 Adult Carcass    108.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0038755 expression level Tissue   Expression Level Larval Central Nervous System    269.9 Larval Midgut    52.2 Larval Hindgut    87 Larval Malpighian Tubules    325.9 Larval Fat Body    86.9 Larval Salivary Gland    107.5 Larval Trachea    810.425 Larval Carcass    139.7 Adult Head    88.6 Adult Eye    126.65 Adult Brain    166.3 Adult Thoracic-Abdominal Ganglion    177.6 Adult Crop    69.4 Adult Midgut    40 Adult Hindgut    57.6 Adult Malpighian Tubules    90.4 Adult Fat Body    180 Adult Salivary Gland    151.1 Adult Heart    151.275 Adult VirginFemale Spermatheca    149.3 Adult InseminatedFemale Spermatheca    141.7 Adult Ovary    195 Adult Testis    16.6 Adult Male Accessory Gland    57.2 Adult Carcass    108.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    269.9 Larval Midgut    52.2 Larval Hindgut    87 Larval Malpighian Tubules    325.9 Larval Fat Body    86.9 Larval Salivary Gland    107.5 Larval Trachea  810.425 Larval Carcass    139.7 Adult Head    88.6 Adult Eye    126.65 Adult Brain    166.3 Adult Thoracic-Abdominal Ganglion    177.6 Adult Crop    69.4 Adult Midgut    40 Adult Hindgut    57.6 Adult Malpighian Tubules    90.4 Adult Fat Body    180 Adult Salivary Gland    151.1 Adult Heart    151.275 Adult VirginFemale Spermatheca    149.3 Adult InseminatedFemale Spermatheca    141.7 Adult Ovary    195 Adult Testis    16.6 Adult Male Accessory Gland    57.2 Adult Carcass    108.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    269.9 Larval Midgut    52.2 Larval Hindgut    87 Larval Malpighian Tubules    325.9 Larval Fat Body    86.9 Larval Salivary Gland    107.5 Larval Trachea    810.425 Larval Carcass    139.7 Adult Head    88.6 Adult Eye    126.65 Adult Brain    166.3 Adult Thoracic-Abdominal Ganglion    177.6 Adult Crop    69.4 Adult Midgut    40 Adult Hindgut    57.6 Adult Malpighian Tubules    90.4 Adult Fat Body    180 Adult Salivary Gland    151.1 Adult Heart    151.275 Adult VirginFemale Spermatheca    149.3 Adult InseminatedFemale Spermatheca    141.7 Adult Ovary    195 Adult Testis    16.6 Adult Male Accessory Gland    57.2 Adult Carcass    108.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    269.9 Larval Midgut    52.2 Larval Hindgut    87 Larval Malpighian Tubules    325.9 Larval Fat Body    86.9 Larval Salivary Gland    107.5 Larval Trachea    810.425 Larval Carcass    139.7 Adult Head    88.6 Adult Eye    126.65 Adult Brain    166.3 Adult Thoracic-Abdominal Ganglion    177.6 Adult Crop    69.4 Adult Midgut    40 Adult Hindgut    57.6 Adult Malpighian Tubules    90.4 Adult Fat Body    180 Adult Salivary Gland    151.1 Adult Heart    151.275 Adult VirginFemale Spermatheca    149.3 Adult InseminatedFemale Spermatheca    141.7 Adult Ovary    195 Adult Testis    16.6 Adult Male Accessory Gland    57.2 Adult Carcass    108.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    88.6   NA  Eye    126.65   NA  Brain    166.3   269.9  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    177.6   NA  Crop    69.4   52.2  Midgut    40   87  Hindgut    57.6   325.9  Malpighian Tubules    90.4   86.9  Fat Body    180   107.5  Salivary Gland    151.1   NA  Heart    151.275   810.425  Trachea    NA   NA  VirginFemale Spermatheca    149.3   NA  InseminatedFemale Spermatheca    141.7   NA  Ovary    195   NA  Testis    16.6   NA  Male Accessory Gland    57.2   139.7  Carcass    108.9 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_05
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0038755 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4451-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Hs6st Stages(s) 4-6 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage, with Hs6sta.cKa Hs6stcKa lethal | embryonic stage, with Hs6stcKa Hs6sta.cKa viable Hs6stEY09299 viable, with Scer\GAL4pnr-MD237 Hs6stGD3078 Sterility Allele fertile Hs6stEY09299 Other Phenotypes Allele visible, with Scer\GAL4GMR.PS Hs6stdsRNA.Scer\UAS Phenotype manifest in Allele embryonic/larval dorsal branch, with Hs6sta.cKa Hs6stcKa embryonic/larval dorsal branch, with Hs6stcKa Hs6sta.cKa embryonic/larval dorsal trunk, with Hs6sta.cKa Hs6stcKa embryonic/larval dorsal trunk, with Hs6stcKa Hs6sta.cKa embryonic/larval lateral trunk, with Hs6sta.cKa Hs6stcKa embryonic/larval lateral trunk, with Hs6stcKa Hs6sta.cKa embryonic/larval trachea Hs6std770 embryonic/larval tracheal system, with Hs6sta.cKa Hs6stcKa embryonic/larval tracheal system, with Hs6stcKa Hs6sta.cKa eye, with Scer\GAL4GMR.PS Hs6stdsRNA.Scer\UAS imaginal tracheoblast Hs6std770 presumptive embryonic/larval tracheal system Hs6std770
Classical Alleles ( 15 )
For All Classical Alleles Show
Allele of Hs6st Class Mutagen Stocks Known lesion Hs6stc03936 1 -- Hs6stc06249 piggyBac transposase 1 -- Hs6ste04101 piggyBac transposase 1 -- Hs6stEY09299 P-element activity 1 -- Hs6stf01916 piggyBac transposase 1 -- Hs6stf02551 1 -- Hs6stf04953 piggyBac transposase 1 -- Hs6stMB06545 1 -- Hs6stMI00358 1 -- Hs6stA201.1M3 P-element activity 0 Yes Hs6stc02717 piggyBac transposase 0 -- Hs6std770 loss of function allele Delta2-3 0 -- Hs6stf02569 piggyBac transposase 0 -- Hs6stf05403 piggyBac transposase 0 -- Hs6stf05898 piggyBac transposase 0 --
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Hs6st Class Mutagen Stocks Known lesion Hs6stGD3078 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Hs6sta.cKa in vitro construct - RNAi 0 Yes Hs6stcKa in vitro construct - RNAi 0 Yes Hs6stdsRNA.IR.Scer\UAS.K in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes Hs6stdsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes Hs6stKK101636 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Hs6stScer\UAS.cKa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD3078} NA P{KK101636} NA P{UAS-Hs6st.IR.K} NA P{UAS-Hs6st.IR} NA P{UAS-Hs6st.K} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}Hs6stEY09299 NA miscellaneous insertions Mi{MIC}Hs6stMI00358 NA PBac{PB}Hs6stc02717 NA PBac{PB}Hs6stc03936 NA PBac{PB}Hs6stc06249 NA PBac{RB}Hs6ste04101 NA PBac{WH}Hs6stf01916 NA PBac{WH}Hs6stf02551 NA PBac{WH}Hs6stf02569 NA PBac{WH}Hs6stf04953 NA PBac{WH}Hs6stf05403 NA PBac{WH}Hs6stf05898 NA insertion of enhancer trap P{lArB}Hs6stA201.1M3 No insertion of enhancer trap binary system Mi{ET1}Hs6stMB06545 No
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
open tracheal system development inferred from genetic interaction with Hs2st (Kamimura et al., 2006) inferred from mutant phenotype (Kamimura et al., 2006)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
heparan sulfate 6-O-sulfotransferase activity non-traceable author statement (Kamimura, 2000.11.29) sulfotransferase activity inferred from electronic annotation with InterPro:IPR005331, InterPro:IPR010635 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
fibroblast growth factor receptor signaling pathway traceable author statement (Ghabrial et al., 2003) heparan sulfate proteoglycan biosynthetic process traceable author statement (Ghabrial et al., 2003) primary branching, open tracheal system traceable author statement (Ghabrial et al., 2003)
Cellular Component
CV term Evidence References
integral to membrane inferred from electronic annotation with InterPro:IPR005331, InterPro:IPR010635 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Hs6st allele Gene References unspecified Papst2 (Goda et al., 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67368 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0038755 DroID - A comprehensive database of gene and protein interactions. • FBgn0038755 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42380
Orthologs
Genome-wide drosophilid orthologs	Dana\GF17343 Dere\GG15697 Dgri\GH19610 Dmoj\GI10319 Dper\GL12524 Dpse\GA28003 Dsec\GM26877 Dsim\mira Dvir\GJ10173 Dwil\GK22800 Dyak\GE25098
Curated drosophilid orthologs	Dpse\GA30239
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AGAP001444-PA Anopheles gambiae (mosquito) XP_396215.1 Apis mellifera (honey bee) XP_001943657.1 Acyrthosiphon pisum (pea aphid) 201764 Branchiostoma floridae (lancelet) 212789 Branchiostoma floridae (lancelet) XP_001894436.1 Brugia malayi (roundworm nematode) BGIBMGA007552-PA Bombyx mori (silk worm) ENSBTAP00000008098 Bos taurus (bovine) CN23282 Caenorhabditis brenneri (small nematode) CBP35628 Caenorhabditis briggsae (nematode) CE32011 Caenorhabditis elegans (worm) ENSCAFP00000027810 Canis familiaris (dog) ENSCINP00000016267 Ciona intestinalis (sea squirt) JA13303 Caenorhabditis japonica (nematode) ENSCPOP00000015115 Cavia porcellus (guinea pig) 24524 Capitella spl (polychaete worm) 303886 Daphnia pulex (daphnia) ENSDARP00000065928 Danio rerio (zebra fish) ENSECAP00000021839 Equus caballus (horse) ENSGACP00000013238 Gymnopilus aculeatus (mushroom) ENSGALP00000003371 Gallus gallus (chicken) ENSP00000259241 Homo sapiens (human) 73915 Lottia gigantea (owl limpet) ENSMODP00000019103 Monodelphis domestica (gray opossum) ENSMMUP00000035987 Macaca mulatta (rhesus monkey) ENSMUSP00000085499 Mus musculus (house mouse) 237290 Nematostella vectensis (starlet anemone) XP_001606887.1 Nasonia vitripennis (wasp) ENSORLP00000002718 Oryzias latipes (japanese killifish) PHUM003517-PA Pediculus humanus (human body louse) PP00992 Pristionchus pacificus (nematode) ENSPPYP00000014230 Pongo pygmaeus (orangutan) ENSPTRP00000021305 Pan troglodytes (chimpanzee) ENSRNOP00000019966 Rattus norvegicus (norway rat) Smp_124020 Schistosoma mansoni (trematode parasite) XP_794153.1 Strongylocentrotus purpuratus (purple sea urchin) 19920 Trichoplax adhaerens (metazoa) XP_970861.1 Tribolium castaneum (red flour beetle) ENSTNIP00000016247 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000032311 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000036573 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15916 NV12798 LH16040 ISCW019457 ISCW015590 FBgn0242185 FBgn0224769 FBgn0197461 FBgn0041661 FBgn0181727 JGI_V11_303886 FBgn0249366 FBgn0150130 FBgn0133084 FBgn0130724 FBgn0127074 FBgn0107941 FBgn0094361 CPIJ012169 CPIJ012170 BGIBMGA007552 ACYPI008758 GB11586 AGAP001444 AAEL000493 PHUM168390 GLEAN_14815
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	32683 y1 w*; Mi{MIC}Hs6stMI00358 16931 y1 w67c23; P{EPgy2}Hs6stEY09299 25513 w1118; Mi{ET1}Hs6stMB06545 CG31213MB06545
Harvard	- PBac{PB}Hs6stc03936 - PBac{PB}Hs6stc06249 - PBac{RB}Hs6ste04101 - PBac{WH}Hs6stf01916 - PBac{WH}Hs6stf02551 - PBac{WH}Hs6stf04953
VDRC	v42658 w1118; P{GD3078}v42658
Genomic Clones ( 2 )
	BACR02O09 BACR10H14 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 60 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD39166
Other clones	DPiM_LD39166
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD03369 LD04075 LD04515 LD11045 LD11547 LD17319 LD19225 LP04716 LP19545 RE02604 RE12326 RE15186 RE19558 RE22267 RE37646 RE38670 RE40108 RE41637 RE46470 RE48596 RE56237 RE61232 RE61390 RE61905 RE64429 RE67191 RH12175 RH52744 RH56460 RH59587
Other clones	8345 16350 59722 60564 73898 214575.47 CK01.36C.A10 CK01.43C.B4 CK01.53C.F11 CK01.68B.D10 CK01.68B.H10 CK01.88A.H12 CK01.104B.E5 CK01.128A.G11 EK031233 EK043322 EK054845 EK054861 EK072262 EK106756 EK184563 EK203250 EK218406 EK304106 EP16813 FGM210B03 RP001003495 RP001036758
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0038755 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42380
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Hs6st CG11683 CG4451 (FlyBase, 1996-)
Source for database merge of	Source for merge of: CG11683 CG18533 (FlyBase, 1996-) Source for merge of: Hs6st CG4451 CG17188 (Misra, 2001.8.10)
Additional comments	Source for identity of Hs6st CG11683 CG4451 was sequence comparison (date:010522). (FlyBase, 1996-) Source for merge of CG11683 CG18533 was sequence comparison (date:001104). (FlyBase, 1996-)
Other Comments
	Levels of 2-O sulfated disaccharides are strikingly elevated in Hs6st mutants. The level of total sulfate groups on heparan sulfate is not affected, and the total charge of heparan sulfate is almost wild-type. (Kamimura et al., 2006) Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days. (Claridge-Chang et al., 2001)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079685 RefSeq (Proteins) • NP_524409 DDBJ / EMBL / GenBank • AAF55724 AAK93326 AB051856 AI519539 AW943455 AY051902 BAB55594 CL528164 CZ468161 CZ468162 CZ470540 CZ481859 CZ484413 CZ484414 CZ485099 CZ487539 CZ487967 CZ488520 CZ488521 Entrez Gene - A searchable database of RefSeq genes. • 42380 UniProtKB/TrEMBL • Q9VDR6 Q968Z7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Heparan sulphate 6-sulfotransferase (IPR010635) Sulfotransferase (IPR005331)
Linkouts
	BioGRID - A database of protein and genetic interactions • 67368 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0038755 DroID - A comprehensive database of gene and protein interactions. • FBgn0038755 DRSC - Results from RNAi screens. • FBgn0038755 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0038755 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4451-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0038755 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42380 InParanoid A subset of ortholog calls from InParanoid. • AGAP001444-PA Anopheles gambiae (mosquito) XP_396215.1 Apis mellifera (honey bee) XP_001943657.1 Acyrthosiphon pisum (pea aphid) 201764 Branchiostoma floridae (lancelet) 212789 Branchiostoma floridae (lancelet) XP_001894436.1 Brugia malayi (roundworm nematode) BGIBMGA007552-PA Bombyx mori (silk worm) ENSBTAP00000008098 Bos taurus (bovine) CN23282 Caenorhabditis brenneri (small nematode) CBP35628 Caenorhabditis briggsae (nematode) CE32011 Caenorhabditis elegans (worm) ENSCAFP00000027810 Canis familiaris (dog) ENSCINP00000016267 Ciona intestinalis (sea squirt) JA13303 Caenorhabditis japonica (nematode) ENSCPOP00000015115 Cavia porcellus (guinea pig) 24524 Capitella spl (polychaete worm) 303886 Daphnia pulex (daphnia) ENSDARP00000065928 Danio rerio (zebra fish) ENSECAP00000021839 Equus caballus (horse) ENSGACP00000013238 Gymnopilus aculeatus (mushroom) ENSGALP00000003371 Gallus gallus (chicken) ENSP00000259241 Homo sapiens (human) 73915 Lottia gigantea (owl limpet) ENSMODP00000019103 Monodelphis domestica (gray opossum) ENSMMUP00000035987 Macaca mulatta (rhesus monkey) ENSMUSP00000085499 Mus musculus (house mouse) 237290 Nematostella vectensis (starlet anemone) XP_001606887.1 Nasonia vitripennis (wasp) ENSORLP00000002718 Oryzias latipes (japanese killifish) PHUM003517-PA Pediculus humanus (human body louse) PP00992 Pristionchus pacificus (nematode) ENSPPYP00000014230 Pongo pygmaeus (orangutan) ENSPTRP00000021305 Pan troglodytes (chimpanzee) ENSRNOP00000019966 Rattus norvegicus (norway rat) Smp_124020 Schistosoma mansoni (trematode parasite) XP_794153.1 Strongylocentrotus purpuratus (purple sea urchin) 19920 Trichoplax adhaerens (metazoa) XP_970861.1 Tribolium castaneum (red flour beetle) ENSTNIP00000016247 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000032311 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000036573 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42380 modMine - Data generated by the modENCODE project. • FBgn0038755 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15916 NV12798 LH16040 ISCW019457 ISCW015590 FBgn0242185 FBgn0224769 FBgn0197461 FBgn0041661 FBgn0181727 JGI_V11_303886 FBgn0249366 FBgn0150130 FBgn0133084 FBgn0130724 FBgn0127074 FBgn0107941 FBgn0094361 CPIJ012169 CPIJ012170 BGIBMGA007552 ACYPI008758 GB11586 AGAP001444 AAEL000493 PHUM168390 GLEAN_14815
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	CG4451 (Quinones-Coello, 2007, Keleman et al., 2009.8.5) CG11683   CG17188 (Misra, 2001.8.10, ) CG18533   dHS6ST (Ghabrial et al., 2003, Butler et al., 2003, Nakato and Kimata, 2002, Ebner et al., 2002, Kamimura, 2000.11.29, Kamimura et al., 2001, Goda et al., 2006, Ueyama et al., 2008) DmHs6st (Nybakken and Perrimon, 2002) Hs6st (Quinones-Coello, 2007, Kamimura et al., 2006, Kleinschmit et al., 2010) hs6st (Sandmann et al., 2007, Brennan, 2007)
Name Synonym	6-O sulfotransferase (Kamimura et al., 2006) 6-O-sulfotransferase (Nishihara, 2010) Heparan sulfate 6-O-sulfotransferase (Kamimura et al., 2001)
Secondary FlyBase IDs
	FBgn0038754 FBgn0038759 FBgn0042209
References ( 31 )
Generate a list of	All references relating to this gene ( 31 )
List References by type	Research paper  ( 10 ) Supplementary material  ( 5 ) Review  ( 4 ) Personal communication to FlyBase  ( 6 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 3 )
Recent research papers ( 2 )
	Kleinschmit et al., 2010, Dev. Biol. 345(2): 204--214 Drosophila heparan sulfate 6-O endosulfatase regulates Wingless morphogen gradient formation. [FBrf0211640] Nishihara, 2010, Methods Enzymol. 480C: 323--351 Glycosyltransferases and Transporters that Contribute to Proteoglycan Synthesis in Drosophila Identification and Functional Analyses Using the Heritable and Inducible RNAi System. [FBrf0211722] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...