Gene Dmel\CG4335

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General Information

Symbol

Dmel\CG4335

Species

D. melanogaster

Name

Annotation symbol

CG4335

Feature type

protein_coding_gene

FlyBase ID

FBgn0038795

Gene Model Status

Current

Stock availability

3 publicly available

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

92E7-92E7

Sequence location

3R:16,232,337..16,233,593 [-]

Genomic Maps

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Summary Information

Automatically generated summary

See sections below for more information

This gene is referred to in FlyBase by the symbol Dmel\CG4335 (FBgn0038795). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: gamma-butyrobetaine dioxygenase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: oxidation-reduction process; carnitine biosynthetic process. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Taurine catabolism dioxygenase TauD/TfdA; Trimethyllysine dioxygenase. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression. Peak expression observed during late pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult fat body, inseminated spermatheca. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult heart, larval fat body, virgin spermatheca, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1638038_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG4335. Gene sequence location is 3R:16232337..16233593.

User Contributed Data

Beta version, feedback welcome

Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

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FB2013_03

FB2013_02

All updates

Click here to see a list of all updates to this record from FB2010_08 and on.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

92E7-92E7

Limits computationally determined from genome sequence between P{PZ}l(3)10585¹⁰⁵⁸⁵ and P{EP}Synd^EP409

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Gene Model & Products

Please see the GBrowse view of Dmel\CG4335 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Comments on Gene Model

Gene model reviewed during 5.50

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

CG4335-RA

FBtr0083894

NM_142629

1198

364

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

CG4335-PA

FBpp0083302

42.2

364

6.15

NP_650886

AAF55763

Additional Polypeptide Data & Comments

Reported size (kDa)

Comments

External Data

Linkouts

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Taurine catabolism dioxygenase TauD/TfdA (IPR003819)

Trimethyllysine dioxygenase (IPR012776)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Q9VDM7

Mapped Features

Mapped Features have been reorganized, please see this article for details.

Additional mapped features and mutations can be found on GBrowse or related reports.

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization (GO Cellular Component)

CV term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

Reference

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

FlyAtlas Anatomy Microarray

FlyAtlas Anatomical Expression Data

(FlyAtlas-RNA.adult)

(FlyAtlas-RNA.larva)

	Styles
	Linear
	Logarithmic
	Heatmap
	Back-to-back
	Scales
	gene max expression
	Moderate expression bin max
	High level expression bin max
	Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult fat body, inseminated spermatheca. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult heart, larval fat body, virgin spermatheca, adult carcass.
[download data (TSV)]

Guide to FlyAtlas expression level colors
	No expression (0 - 9.999)
	Low expression (10 - 99.999)
	Moderate expression (100 - 499.999)
	High level expression (500 - 999.999)
	Very high expression (>999.999)

Linear, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		2.325
Larval Midgut		5.1
Larval Hindgut		15.1
Larval Malpighian Tubules		3.3
Larval Fat Body		149.8
Larval Salivary Gland		20.5
Larval Trachea		9.125
Larval Carcass		6.65
Adult Head		285.7
Adult Eye		74.95
Adult Brain		6.2
Adult Thoracic-Abdominal Ganglion		7.7
Adult Crop		11.7
Adult Midgut		1.4
Adult Hindgut		19.4
Adult Malpighian Tubules		10.5
Adult Fat Body		593.8
Adult Salivary Gland		13.3
Adult Heart		290.225
Adult VirginFemale Spermatheca		358.1
Adult InseminatedFemale Spermatheca		564.8
Adult Ovary		2
Adult Testis		2.8
Adult Male Accessory Gland		2.1
Adult Carcass		310.1
Expression Level Scale		None Low Moderate High

Linear, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		2.325
Larval Midgut		5.1
Larval Hindgut		15.1
Larval Malpighian Tubules		3.3
Larval Fat Body		149.8
Larval Salivary Gland		20.5
Larval Trachea		9.125
Larval Carcass		6.65
Adult Head		285.7
Adult Eye		74.95
Adult Brain		6.2
Adult Thoracic-Abdominal Ganglion		7.7
Adult Crop		11.7
Adult Midgut		1.4
Adult Hindgut		19.4
Adult Malpighian Tubules		10.5
Adult Fat Body		(593.8)
Adult Salivary Gland		13.3
Adult Heart		290.225
Adult VirginFemale Spermatheca		358.1
Adult InseminatedFemale Spermatheca		(564.8)
Adult Ovary		2
Adult Testis		2.8
Adult Male Accessory Gland		2.1
Adult Carcass		310.1
Expression Level Scale		None Low Moderate High

Linear, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		2.325
Larval Midgut		5.1
Larval Hindgut		15.1
Larval Malpighian Tubules		3.3
Larval Fat Body		149.8
Larval Salivary Gland		20.5
Larval Trachea		9.125
Larval Carcass		6.65
Adult Head		285.7
Adult Eye		74.95
Adult Brain		6.2
Adult Thoracic-Abdominal Ganglion		7.7
Adult Crop		11.7
Adult Midgut		1.4
Adult Hindgut		19.4
Adult Malpighian Tubules		10.5
Adult Fat Body		593.8
Adult Salivary Gland		13.3
Adult Heart		290.225
Adult VirginFemale Spermatheca		358.1
Adult InseminatedFemale Spermatheca		564.8
Adult Ovary		2
Adult Testis		2.8
Adult Male Accessory Gland		2.1
Adult Carcass		310.1
Expression Level Scale		None Low Moderate High Very high

Linear, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		2.325
Larval Midgut		5.1
Larval Hindgut		15.1
Larval Malpighian Tubules		3.3
Larval Fat Body		149.8
Larval Salivary Gland		20.5
Larval Trachea		9.125
Larval Carcass		6.65
Adult Head		285.7
Adult Eye		74.95
Adult Brain		6.2
Adult Thoracic-Abdominal Ganglion		7.7
Adult Crop		11.7
Adult Midgut		1.4
Adult Hindgut		19.4
Adult Malpighian Tubules		10.5
Adult Fat Body		593.8
Adult Salivary Gland		13.3
Adult Heart		290.225
Adult VirginFemale Spermatheca		358.1
Adult InseminatedFemale Spermatheca		564.8
Adult Ovary		2
Adult Testis		2.8
Adult Male Accessory Gland		2.1
Adult Carcass		310.1
Expression Level Scale		Very high

log, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		2.325
Larval Midgut		5.1
Larval Hindgut		15.1
Larval Malpighian Tubules		3.3
Larval Fat Body		149.8
Larval Salivary Gland		20.5
Larval Trachea		9.125
Larval Carcass		6.65
Adult Head		285.7
Adult Eye		74.95
Adult Brain		6.2
Adult Thoracic-Abdominal Ganglion		7.7
Adult Crop		11.7
Adult Midgut		1.4
Adult Hindgut		19.4
Adult Malpighian Tubules		10.5
Adult Fat Body		593.8
Adult Salivary Gland		13.3
Adult Heart		290.225
Adult VirginFemale Spermatheca		358.1
Adult InseminatedFemale Spermatheca		564.8
Adult Ovary		2
Adult Testis		2.8
Adult Male Accessory Gland		2.1
Adult Carcass		310.1
Expression Level Scale		None Low Moderate High Very high

log, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		2.325
Larval Midgut		5.1
Larval Hindgut		15.1
Larval Malpighian Tubules		3.3
Larval Fat Body		149.8
Larval Salivary Gland		20.5
Larval Trachea		9.125
Larval Carcass		6.65
Adult Head		285.7
Adult Eye		74.95
Adult Brain		6.2
Adult Thoracic-Abdominal Ganglion		7.7
Adult Crop		11.7
Adult Midgut		1.4
Adult Hindgut		19.4
Adult Malpighian Tubules		10.5
Adult Fat Body		593.8
Adult Salivary Gland		13.3
Adult Heart		290.225
Adult VirginFemale Spermatheca		358.1
Adult InseminatedFemale Spermatheca		564.8
Adult Ovary		2
Adult Testis		2.8
Adult Male Accessory Gland		2.1
Adult Carcass		310.1
Expression Level Scale		None Low Moderate High

log, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		2.325
Larval Midgut		5.1
Larval Hindgut		15.1
Larval Malpighian Tubules		3.3
Larval Fat Body		149.8
Larval Salivary Gland		20.5
Larval Trachea		9.125
Larval Carcass		6.65
Adult Head		285.7
Adult Eye		74.95
Adult Brain		6.2
Adult Thoracic-Abdominal Ganglion		7.7
Adult Crop		11.7
Adult Midgut		1.4
Adult Hindgut		19.4
Adult Malpighian Tubules		10.5
Adult Fat Body		593.8
Adult Salivary Gland		13.3
Adult Heart		290.225
Adult VirginFemale Spermatheca		358.1
Adult InseminatedFemale Spermatheca		564.8
Adult Ovary		2
Adult Testis		2.8
Adult Male Accessory Gland		2.1
Adult Carcass		310.1
Expression Level Scale		None Low Moderate High Very high

log, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		2.325
Larval Midgut		5.1
Larval Hindgut		15.1
Larval Malpighian Tubules		3.3
Larval Fat Body		149.8
Larval Salivary Gland		20.5
Larval Trachea		9.125
Larval Carcass		6.65
Adult Head		285.7
Adult Eye		74.95
Adult Brain		6.2
Adult Thoracic-Abdominal Ganglion		7.7
Adult Crop		11.7
Adult Midgut		1.4
Adult Hindgut		19.4
Adult Malpighian Tubules		10.5
Adult Fat Body		593.8
Adult Salivary Gland		13.3
Adult Heart		290.225
Adult VirginFemale Spermatheca		358.1
Adult InseminatedFemale Spermatheca		564.8
Adult Ovary		2
Adult Testis		2.8
Adult Male Accessory Gland		2.1
Adult Carcass		310.1
Expression Level Scale		None Low Moderate High Very high

Heatmap
Tissue		Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level	Tissue	Adult Expression Level
NA	Head	285.7
NA	Eye	74.95
NA	Brain	6.2
2.325	Central Nervous System	NA
NA	Thoracic-Abdominal Ganglion	7.7
NA	Crop	no informative data
5.1	Midgut	1.4
no informative data	Hindgut	19.4
3.3	Malpighian Tubules	no informative data
149.8	Fat Body	593.8
no informative data	Salivary Gland	no informative data
NA	Heart	290.225
9.125	Trachea	NA
NA	VirginFemale Spermatheca	358.1
NA	InseminatedFemale Spermatheca	564.8
NA	Ovary	2
NA	Testis	2.8
NA	Male Accessory Gland	2.1
6.65	Carcass	310.1

FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)

modENCODE Anatomy RNA-Seq

modENCODE Tissue Expression Data

(modENCODE_mRNA-Seq_tissues)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		0
central nervous system, larvae L3		0
central nervous system, pupae P8		0
head, virgin 1-day female		6
head, virgin 4-day female		4
head, virgin 20-day female		11
head, mated 1-day female		4
head, mated 4-day female		8
head, mated 20-day female		9
head, mated 1-day male		4
head, mated 4-day male		6
head, mated 20-day male		6
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		1
digestive system, 4-day adult		0
digestive system, 20-day adult		0
fat body, larvae L3 wandering		7
fat body, white prepupae		0
fat body, pupae P8		36
carcass, larvae L3 wandering		0
carcass, 1-day adult		4
carcass, 4-day adult		5
carcass, 20-day adult		3
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		0
accessory gland, mated 4-day male		0
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		0
central nervous system, larvae L3		0
central nervous system, pupae P8		0
head, virgin 1-day female		6
head, virgin 4-day female		4
head, virgin 20-day female		11
head, mated 1-day female		4
head, mated 4-day female		8
head, mated 20-day female		9
head, mated 1-day male		4
head, mated 4-day male		6
head, mated 20-day male		6
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		1
digestive system, 4-day adult		0
digestive system, 20-day adult		0
fat body, larvae L3 wandering		7
fat body, white prepupae		0
fat body, pupae P8		(36)
carcass, larvae L3 wandering		0
carcass, 1-day adult		4
carcass, 4-day adult		5
carcass, 20-day adult		3
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		0
accessory gland, mated 4-day male		0
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		0
central nervous system, larvae L3		0
central nervous system, pupae P8		0
head, virgin 1-day female		6
head, virgin 4-day female		4
head, virgin 20-day female		11
head, mated 1-day female		4
head, mated 4-day female		8
head, mated 20-day female		9
head, mated 1-day male		4
head, mated 4-day male		6
head, mated 20-day male		6
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		1
digestive system, 4-day adult		0
digestive system, 20-day adult		0
fat body, larvae L3 wandering		7
fat body, white prepupae		0
fat body, pupae P8		36
carcass, larvae L3 wandering		0
carcass, 1-day adult		4
carcass, 4-day adult		5
carcass, 20-day adult		3
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		0
accessory gland, mated 4-day male		0
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		0
central nervous system, larvae L3		0
central nervous system, pupae P8		0
head, virgin 1-day female		6
head, virgin 4-day female		4
head, virgin 20-day female		11
head, mated 1-day female		4
head, mated 4-day female		8
head, mated 20-day female		9
head, mated 1-day male		4
head, mated 4-day male		6
head, mated 20-day male		6
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		1
digestive system, 4-day adult		0
digestive system, 20-day adult		0
fat body, larvae L3 wandering		7
fat body, white prepupae		0
fat body, pupae P8		36
carcass, larvae L3 wandering		0
carcass, 1-day adult		4
carcass, 4-day adult		5
carcass, 20-day adult		3
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		0
accessory gland, mated 4-day male		0
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		0
central nervous system, larvae L3		0
central nervous system, pupae P8		0
head, virgin 1-day female		6
head, virgin 4-day female		4
head, virgin 20-day female		11
head, mated 1-day female		4
head, mated 4-day female		8
head, mated 20-day female		9
head, mated 1-day male		4
head, mated 4-day male		6
head, mated 20-day male		6
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		1
digestive system, 4-day adult		0
digestive system, 20-day adult		0
fat body, larvae L3 wandering		7
fat body, white prepupae		0
fat body, pupae P8		36
carcass, larvae L3 wandering		0
carcass, 1-day adult		4
carcass, 4-day adult		5
carcass, 20-day adult		3
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		0
accessory gland, mated 4-day male		0
Expression Level Scale		Very low Low Moderate Moderately high High

log, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		0
central nervous system, larvae L3		0
central nervous system, pupae P8		0
head, virgin 1-day female		6
head, virgin 4-day female		4
head, virgin 20-day female		11
head, mated 1-day female		4
head, mated 4-day female		8
head, mated 20-day female		9
head, mated 1-day male		4
head, mated 4-day male		6
head, mated 20-day male		6
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		1
digestive system, 4-day adult		0
digestive system, 20-day adult		0
fat body, larvae L3 wandering		7
fat body, white prepupae		0
fat body, pupae P8		(36)
carcass, larvae L3 wandering		0
carcass, 1-day adult		4
carcass, 4-day adult		5
carcass, 20-day adult		3
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		0
accessory gland, mated 4-day male		0
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		0
central nervous system, larvae L3		0
central nervous system, pupae P8		0
head, virgin 1-day female		6
head, virgin 4-day female		4
head, virgin 20-day female		11
head, mated 1-day female		4
head, mated 4-day female		8
head, mated 20-day female		9
head, mated 1-day male		4
head, mated 4-day male		6
head, mated 20-day male		6
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		1
digestive system, 4-day adult		0
digestive system, 20-day adult		0
fat body, larvae L3 wandering		7
fat body, white prepupae		0
fat body, pupae P8		36
carcass, larvae L3 wandering		0
carcass, 1-day adult		4
carcass, 4-day adult		5
carcass, 20-day adult		3
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		0
accessory gland, mated 4-day male		0
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		0
central nervous system, larvae L3		0
central nervous system, pupae P8		0
head, virgin 1-day female		6
head, virgin 4-day female		4
head, virgin 20-day female		11
head, mated 1-day female		4
head, mated 4-day female		8
head, mated 20-day female		9
head, mated 1-day male		4
head, mated 4-day male		6
head, mated 20-day male		6
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		1
digestive system, 4-day adult		0
digestive system, 20-day adult		0
fat body, larvae L3 wandering		7
fat body, white prepupae		0
fat body, pupae P8		36
carcass, larvae L3 wandering		0
carcass, 1-day adult		4
carcass, 4-day adult		5
carcass, 20-day adult		3
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		0
accessory gland, mated 4-day male		0
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Tissue		Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male

modENCODE Development RNA-Seq

modENCODE Temporal Expression Data

(modENCODE_mRNA-Seq_U)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression. Peak expression observed during late pupal stages.
[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		3
embryo 08-10hr		9
embryo 10-12hr		12
embryo 12-14hr		11
embryo 14-16hr		5
embryo 16-18hr		4
embryo 18-20hr		2
embryo 20-22hr		1
embryo 22-24hr		2
larva L1		17
larva L2		27
larva L3 12hr old		40
larva L3 puffstage 1-2		30
larva L3 puffstage 3-6		7
larva L3 puffstage 7-9		2
white prepupae new		3
white prepupae 12hr		9
white prepupae 24hr		49
pupae 2d postWPP		71
pupae 3d postWPP		18
pupae 4d postWPP		3
adult male 01day		8
adult male 05day		9
adult male 30day		7
adult female 01day		4
adult female 05day		6
adult female 30day		6
Expression Level Scale		Very low Low Moderate Moderately high High

Linear, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		3
embryo 08-10hr		9
embryo 10-12hr		12
embryo 12-14hr		11
embryo 14-16hr		5
embryo 16-18hr		4
embryo 18-20hr		2
embryo 20-22hr		1
embryo 22-24hr		2
larva L1		17
larva L2		(27)
larva L3 12hr old		(40)
larva L3 puffstage 1-2		(30)
larva L3 puffstage 3-6		7
larva L3 puffstage 7-9		2
white prepupae new		3
white prepupae 12hr		9
white prepupae 24hr		(49)
pupae 2d postWPP		(71)
pupae 3d postWPP		18
pupae 4d postWPP		3
adult male 01day		8
adult male 05day		9
adult male 30day		7
adult female 01day		4
adult female 05day		6
adult female 30day		6
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		3
embryo 08-10hr		9
embryo 10-12hr		12
embryo 12-14hr		11
embryo 14-16hr		5
embryo 16-18hr		4
embryo 18-20hr		2
embryo 20-22hr		1
embryo 22-24hr		2
larva L1		17
larva L2		27
larva L3 12hr old		40
larva L3 puffstage 1-2		30
larva L3 puffstage 3-6		7
larva L3 puffstage 7-9		2
white prepupae new		3
white prepupae 12hr		9
white prepupae 24hr		49
pupae 2d postWPP		71
pupae 3d postWPP		18
pupae 4d postWPP		3
adult male 01day		8
adult male 05day		9
adult male 30day		7
adult female 01day		4
adult female 05day		6
adult female 30day		6
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		3
embryo 08-10hr		9
embryo 10-12hr		12
embryo 12-14hr		11
embryo 14-16hr		5
embryo 16-18hr		4
embryo 18-20hr		2
embryo 20-22hr		1
embryo 22-24hr		2
larva L1		17
larva L2		27
larva L3 12hr old		40
larva L3 puffstage 1-2		30
larva L3 puffstage 3-6		7
larva L3 puffstage 7-9		2
white prepupae new		3
white prepupae 12hr		9
white prepupae 24hr		49
pupae 2d postWPP		71
pupae 3d postWPP		18
pupae 4d postWPP		3
adult male 01day		8
adult male 05day		9
adult male 30day		7
adult female 01day		4
adult female 05day		6
adult female 30day		6
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		3
embryo 08-10hr		9
embryo 10-12hr		12
embryo 12-14hr		11
embryo 14-16hr		5
embryo 16-18hr		4
embryo 18-20hr		2
embryo 20-22hr		1
embryo 22-24hr		2
larva L1		17
larva L2		27
larva L3 12hr old		40
larva L3 puffstage 1-2		30
larva L3 puffstage 3-6		7
larva L3 puffstage 7-9		2
white prepupae new		3
white prepupae 12hr		9
white prepupae 24hr		49
pupae 2d postWPP		71
pupae 3d postWPP		18
pupae 4d postWPP		3
adult male 01day		8
adult male 05day		9
adult male 30day		7
adult female 01day		4
adult female 05day		6
adult female 30day		6
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		3
embryo 08-10hr		9
embryo 10-12hr		12
embryo 12-14hr		11
embryo 14-16hr		5
embryo 16-18hr		4
embryo 18-20hr		2
embryo 20-22hr		1
embryo 22-24hr		2
larva L1		17
larva L2		27
larva L3 12hr old		(40)
larva L3 puffstage 1-2		30
larva L3 puffstage 3-6		7
larva L3 puffstage 7-9		2
white prepupae new		3
white prepupae 12hr		9
white prepupae 24hr		(49)
pupae 2d postWPP		(71)
pupae 3d postWPP		18
pupae 4d postWPP		3
adult male 01day		8
adult male 05day		9
adult male 30day		7
adult female 01day		4
adult female 05day		6
adult female 30day		6
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		3
embryo 08-10hr		9
embryo 10-12hr		12
embryo 12-14hr		11
embryo 14-16hr		5
embryo 16-18hr		4
embryo 18-20hr		2
embryo 20-22hr		1
embryo 22-24hr		2
larva L1		17
larva L2		27
larva L3 12hr old		40
larva L3 puffstage 1-2		30
larva L3 puffstage 3-6		7
larva L3 puffstage 7-9		2
white prepupae new		3
white prepupae 12hr		9
white prepupae 24hr		49
pupae 2d postWPP		71
pupae 3d postWPP		18
pupae 4d postWPP		3
adult male 01day		8
adult male 05day		9
adult male 30day		7
adult female 01day		4
adult female 05day		6
adult female 30day		6
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		3
embryo 08-10hr		9
embryo 10-12hr		12
embryo 12-14hr		11
embryo 14-16hr		5
embryo 16-18hr		4
embryo 18-20hr		2
embryo 20-22hr		1
embryo 22-24hr		2
larva L1		17
larva L2		27
larva L3 12hr old		40
larva L3 puffstage 1-2		30
larva L3 puffstage 3-6		7
larva L3 puffstage 7-9		2
white prepupae new		3
white prepupae 12hr		9
white prepupae 24hr		49
pupae 2d postWPP		71
pupae 3d postWPP		18
pupae 4d postWPP		3
adult male 01day		8
adult male 05day		9
adult male 30day		7
adult female 01day		4
adult female 05day		6
adult female 30day		6
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Developmental Stage		Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day

modENCODE Temporal Expression Data (Graveley et al., 2011)

modENCODE Cell Lines RNA-Seq

modENCODE Treatments RNA-Seq

modENCODE Treatment Expression Data

(modENCODE_mRNA-Seq_treatments)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		0
cold shock, 4-day adult		0
heat shock, 4-day adult		3
Cadmium 50 mM 6 hrs, larvae L3		10
Cadmium 50 mM 12 hrs, larvae L3		8
Cadmium 50 mM 48 hrs, 4-day adult		4
Cadmium 100 mM 48 hrs, 4-day adult		1
Copper 0.5 mM 12 hrs, larvae L3		1
Copper 15 mM 48 hrs, 4-day adult		2
Zinc 5 mM 12 hrs, larvae L3		2
Zinc 4.5 mM 48 hrs, 4-day adult		0
Ethanol 2.5% 3 hrs, larvae L3		1
Ethanol 5% 3 hrs, larvae L3		12
Ethanol 10% 3 hrs, larvae L3		9
Caffeine 1.5 mg/ml 4 hrs, larvae L3		14
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		1
Caffeine 25 mg/ml 48 hrs, 4-day adult		1
Paraquat 5 mM 48 hrs, 4-day adult		2
Paraquat 10 mM 48 hrs, 4-day adult		2
Rotenone 2 μg 12 hrs, larvae L3		13
Rotenone 8 μg 12 hrs, larvae L3		5
Expression Level Scale		Very low Low Moderate

Linear, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		0
cold shock, 4-day adult		0
heat shock, 4-day adult		3
Cadmium 50 mM 6 hrs, larvae L3		10
Cadmium 50 mM 12 hrs, larvae L3		8
Cadmium 50 mM 48 hrs, 4-day adult		4
Cadmium 100 mM 48 hrs, 4-day adult		1
Copper 0.5 mM 12 hrs, larvae L3		1
Copper 15 mM 48 hrs, 4-day adult		2
Zinc 5 mM 12 hrs, larvae L3		2
Zinc 4.5 mM 48 hrs, 4-day adult		0
Ethanol 2.5% 3 hrs, larvae L3		1
Ethanol 5% 3 hrs, larvae L3		12
Ethanol 10% 3 hrs, larvae L3		9
Caffeine 1.5 mg/ml 4 hrs, larvae L3		14
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		1
Caffeine 25 mg/ml 48 hrs, 4-day adult		1
Paraquat 5 mM 48 hrs, 4-day adult		2
Paraquat 10 mM 48 hrs, 4-day adult		2
Rotenone 2 μg 12 hrs, larvae L3		13
Rotenone 8 μg 12 hrs, larvae L3		5
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		0
cold shock, 4-day adult		0
heat shock, 4-day adult		3
Cadmium 50 mM 6 hrs, larvae L3		10
Cadmium 50 mM 12 hrs, larvae L3		8
Cadmium 50 mM 48 hrs, 4-day adult		4
Cadmium 100 mM 48 hrs, 4-day adult		1
Copper 0.5 mM 12 hrs, larvae L3		1
Copper 15 mM 48 hrs, 4-day adult		2
Zinc 5 mM 12 hrs, larvae L3		2
Zinc 4.5 mM 48 hrs, 4-day adult		0
Ethanol 2.5% 3 hrs, larvae L3		1
Ethanol 5% 3 hrs, larvae L3		12
Ethanol 10% 3 hrs, larvae L3		9
Caffeine 1.5 mg/ml 4 hrs, larvae L3		14
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		1
Caffeine 25 mg/ml 48 hrs, 4-day adult		1
Paraquat 5 mM 48 hrs, 4-day adult		2
Paraquat 10 mM 48 hrs, 4-day adult		2
Rotenone 2 μg 12 hrs, larvae L3		13
Rotenone 8 μg 12 hrs, larvae L3		5
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		0
cold shock, 4-day adult		0
heat shock, 4-day adult		3
Cadmium 50 mM 6 hrs, larvae L3		10
Cadmium 50 mM 12 hrs, larvae L3		8
Cadmium 50 mM 48 hrs, 4-day adult		4
Cadmium 100 mM 48 hrs, 4-day adult		1
Copper 0.5 mM 12 hrs, larvae L3		1
Copper 15 mM 48 hrs, 4-day adult		2
Zinc 5 mM 12 hrs, larvae L3		2
Zinc 4.5 mM 48 hrs, 4-day adult		0
Ethanol 2.5% 3 hrs, larvae L3		1
Ethanol 5% 3 hrs, larvae L3		12
Ethanol 10% 3 hrs, larvae L3		9
Caffeine 1.5 mg/ml 4 hrs, larvae L3		14
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		1
Caffeine 25 mg/ml 48 hrs, 4-day adult		1
Paraquat 5 mM 48 hrs, 4-day adult		2
Paraquat 10 mM 48 hrs, 4-day adult		2
Rotenone 2 μg 12 hrs, larvae L3		13
Rotenone 8 μg 12 hrs, larvae L3		5
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		0
cold shock, 4-day adult		0
heat shock, 4-day adult		3
Cadmium 50 mM 6 hrs, larvae L3		10
Cadmium 50 mM 12 hrs, larvae L3		8
Cadmium 50 mM 48 hrs, 4-day adult		4
Cadmium 100 mM 48 hrs, 4-day adult		1
Copper 0.5 mM 12 hrs, larvae L3		1
Copper 15 mM 48 hrs, 4-day adult		2
Zinc 5 mM 12 hrs, larvae L3		2
Zinc 4.5 mM 48 hrs, 4-day adult		0
Ethanol 2.5% 3 hrs, larvae L3		1
Ethanol 5% 3 hrs, larvae L3		12
Ethanol 10% 3 hrs, larvae L3		9
Caffeine 1.5 mg/ml 4 hrs, larvae L3		14
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		1
Caffeine 25 mg/ml 48 hrs, 4-day adult		1
Paraquat 5 mM 48 hrs, 4-day adult		2
Paraquat 10 mM 48 hrs, 4-day adult		2
Rotenone 2 μg 12 hrs, larvae L3		13
Rotenone 8 μg 12 hrs, larvae L3		5
Expression Level Scale		Very low Low Moderate

log, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		0
cold shock, 4-day adult		0
heat shock, 4-day adult		3
Cadmium 50 mM 6 hrs, larvae L3		10
Cadmium 50 mM 12 hrs, larvae L3		8
Cadmium 50 mM 48 hrs, 4-day adult		4
Cadmium 100 mM 48 hrs, 4-day adult		1
Copper 0.5 mM 12 hrs, larvae L3		1
Copper 15 mM 48 hrs, 4-day adult		2
Zinc 5 mM 12 hrs, larvae L3		2
Zinc 4.5 mM 48 hrs, 4-day adult		0
Ethanol 2.5% 3 hrs, larvae L3		1
Ethanol 5% 3 hrs, larvae L3		12
Ethanol 10% 3 hrs, larvae L3		9
Caffeine 1.5 mg/ml 4 hrs, larvae L3		14
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		1
Caffeine 25 mg/ml 48 hrs, 4-day adult		1
Paraquat 5 mM 48 hrs, 4-day adult		2
Paraquat 10 mM 48 hrs, 4-day adult		2
Rotenone 2 μg 12 hrs, larvae L3		13
Rotenone 8 μg 12 hrs, larvae L3		5
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		0
cold shock, 4-day adult		0
heat shock, 4-day adult		3
Cadmium 50 mM 6 hrs, larvae L3		10
Cadmium 50 mM 12 hrs, larvae L3		8
Cadmium 50 mM 48 hrs, 4-day adult		4
Cadmium 100 mM 48 hrs, 4-day adult		1
Copper 0.5 mM 12 hrs, larvae L3		1
Copper 15 mM 48 hrs, 4-day adult		2
Zinc 5 mM 12 hrs, larvae L3		2
Zinc 4.5 mM 48 hrs, 4-day adult		0
Ethanol 2.5% 3 hrs, larvae L3		1
Ethanol 5% 3 hrs, larvae L3		12
Ethanol 10% 3 hrs, larvae L3		9
Caffeine 1.5 mg/ml 4 hrs, larvae L3		14
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		1
Caffeine 25 mg/ml 48 hrs, 4-day adult		1
Paraquat 5 mM 48 hrs, 4-day adult		2
Paraquat 10 mM 48 hrs, 4-day adult		2
Rotenone 2 μg 12 hrs, larvae L3		13
Rotenone 8 μg 12 hrs, larvae L3		5
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		0
cold shock, 4-day adult		0
heat shock, 4-day adult		3
Cadmium 50 mM 6 hrs, larvae L3		10
Cadmium 50 mM 12 hrs, larvae L3		8
Cadmium 50 mM 48 hrs, 4-day adult		4
Cadmium 100 mM 48 hrs, 4-day adult		1
Copper 0.5 mM 12 hrs, larvae L3		1
Copper 15 mM 48 hrs, 4-day adult		2
Zinc 5 mM 12 hrs, larvae L3		2
Zinc 4.5 mM 48 hrs, 4-day adult		0
Ethanol 2.5% 3 hrs, larvae L3		1
Ethanol 5% 3 hrs, larvae L3		12
Ethanol 10% 3 hrs, larvae L3		9
Caffeine 1.5 mg/ml 4 hrs, larvae L3		14
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		1
Caffeine 25 mg/ml 48 hrs, 4-day adult		1
Paraquat 5 mM 48 hrs, 4-day adult		2
Paraquat 10 mM 48 hrs, 4-day adult		2
Rotenone 2 μg 12 hrs, larvae L3		13
Rotenone 8 μg 12 hrs, larvae L3		5
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Treatment		Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3

Expression Clusters

A cluster of genes with similar mRNA expression dynamics across development.

(The modENCODE Consortium, 2010)

mE2_34_mRNA_expression_cluster_25

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0038795

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG4335-RA

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

viable, with Scer\GAL4^pnr-MD237

CG4335^GD11285

Phenotype manifest in

Allele

Classical Alleles ( 0 )

For All Classical Alleles Show

Allele of CG4335	Class	Mutagen	Stocks	Known lesion

Alleles Carried on Transgenic Constructs ( 3 )

For All Alleles Carried on Transgenic Constructs Show

Allele of CG4335	Mutagen	Stocks	Known lesion
CG4335^GD11285	in vitro construct - RNAi in vitro construct - regulatory fusion	2	Yes
CG4335^KK100509	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
CG4335^NIG.4335R	in vitro construct - RNAi in vitro construct - regulatory fusion	0	Yes

Aneuploid Aberrations

Disrupted in

Df(3R)Exel6185

(Ryder, 2004.4.26)

Df(3R)Gfrl^del

(Kallijärvi et al., 2012)

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD11285}

P{KK100509}

P{NIG.4335R}

Insertions

Type of insertions

Name

Expression data

Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )

Terms Based on Experimental Evidence ( 0 terms )

Terms Based on Predictions or Assertions ( 6 terms )

Molecular Function

CV term

Evidence

References

gamma-butyrobetaine dioxygenase activity

inferred from sequence or structural similarity with NCBI_gi:4502369

(FlyBase, 1992-)

iron ion binding

inferred from electronic annotation with InterPro:IPR012776

(FlyBase Curators et al., 2004-)

L-ascorbic acid binding

inferred from electronic annotation with InterPro:IPR012776

(FlyBase Curators et al., 2004-)

trimethyllysine dioxygenase activity

inferred from electronic annotation with InterPro:IPR012776

(FlyBase Curators et al., 2004-)

Biological Process

CV term

Evidence

References

carnitine biosynthetic process

inferred from electronic annotation with InterPro:IPR012776

(FlyBase Curators et al., 2004-)

oxidation-reduction process

inferred from electronic annotation with InterPro:IPR003819, InterPro:IPR012776

(FlyBase Curators et al., 2004-)

Cellular Component ( 0 terms)

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Interactions & Pathways

Summary of Physical Interactions

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

CG4335 allele

Gene

References

External Data

Linkouts

BioGRID - A database of protein and genetic interactions

•

67401

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0038795

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

42421

Orthologs

OrthoDB Orthologs (29) - based on analysis using Dmel annotation version 5.41

OrthoDB Ortholog Groups

OrthoDB orthology group searches

(Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288)

Drosophila inclusive ortholog search

EOG6CZC1V

Dipteran inclusive ortholog search

EOG6614CJ

Insect inclusive ortholog search

EOG6C86NW

Arthropod inclusive ortholog search

EOG6KWH88

Metazoa inclusive ortholog search

EOG6CGC2V

Orthologs in Drosophila Species (EOG6CZC1V)

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA18117

Drosophila persimilis

Dper\GL24093

Drosophila willistoni

Dwil\GK22732

Drosophila virilis

Dvir\GJ24198

Drosophila mojavensis

Dmoj\GI10544

Drosophila grimshawi

Dgri\GH14171

Orthologs in non-Drosophila Dipterans (EOG6614CJ)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL009731

Anopheles gambiae

Malaria mosquito

Agam\AGAP005447

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ012189

Orthologs in non-Dipteran Insects (EOG6C86NW)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI008997

Bombyx mori

Silkmoth

Bmor\BGIBMGA001273

Pediculus humanus

Human body louse

Phum\PHUM613090

Orthologs in non-Insect Arthropods (EOG6KWH88)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Daphnia pulex

Water flea

Dpux\Serp1

Orthologs in non-Arthropod Metazoa (EOG6CGC2V)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Caenorhabditis elegans

Nematode

Cele\gbh-2

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_007321gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_009359gn

Danio rerio

Zebrafish

Drer\OTTDARG00000031573

Xenopus tropicalis

Western clawed frog

Xtro\tmlhe

Gallus gallus

Domestic chicken

Ggal\TMLHE

Mus musculus

House mouse

Mmus\Tmlhe

Rattus norvegicus

Norway rat

Rnor\ENSRNOG00000000729

Homo sapiens

Human

Hsap\TMLHE

Human Orthologs (1)

Gene

OMIM

HGNC

Hsap\TMLHE

AAA Orthologs (11) based on analysis using Dmel annotation version 4.3

Organism

Gene

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA18117

Drosophila persimilis

Dper\GL24093

Drosophila willistoni

Dwil\GK22732

Drosophila virilis

Dvir\GJ24198

Drosophila mojavensis

Dmoj\GI10544

Drosophila grimshawi

Dgri\GH14171

Stocks & Reagents

Stocks Listed in FlyBase ( 3 )

VDRC

v105611

P{KK100509}VIE-260B

v26514

w¹¹¹⁸; P{GD11285}v26514

v26515

w¹¹¹⁸; P{GD11285}v26515

Genomic Clones ( 2 )

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones ( 4 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

IP11227

RNAi & Array Information

Linkouts

DRSC - Results from RNAi screens.

•

FBgn0038795

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

42421

Antibody Information

Other Information

Discoverer

Etymology

Identification

Relationship to Other Genes

Source for database identity of

Source for database merge of

Additional comments

Other Comments

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

NM_142629

RefSeq (Proteins)

•

NP_650886

DDBJ / EMBL / GenBank

•

AAF55763

Entrez Gene - A searchable database of RefSeq genes.

•

42421

UniProtKB/TrEMBL

•

Q9VDM7

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Taurine catabolism dioxygenase TauD/TfdA (IPR003819)

Trimethyllysine dioxygenase (IPR012776)

Linkouts

BioGRID - A database of protein and genetic interactions

•

67401

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0038795

DRSC - Results from RNAi screens.

•

FBgn0038795

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0038795

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG4335-RA

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0038795

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

42421

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

42421

modMine - Data generated by the modENCODE project.

•

FBgn0038795

Synonyms & Secondary IDs ( 1 )

Reported As

Symbol Synonym

CG4335

(Egli et al., 2006, Shieh and Bonini, 2011, Palanker et al., 2009, Keleman et al., 2009.8.5, Japanese National Institute of Genetics, 2012.5.21)

Name Synonym

Secondary FlyBase IDs

References ( 14 )

Research paper

Kallijärvi et al., 2012, PLoS ONE 7(12): e51997: Characterization of Drosophila GDNF Receptor-Like and Evidence for Its Evolutionarily Conserved Interaction with Neural Cell Adhesion Molecule (NCAM)/FasII. [FBrf0220419]
Shieh and Bonini, 2011, Hum. Mol. Genet. 20(24): 4810--4821: Genes and pathways affected by CAG-repeat RNA-based toxicity in Drosophila. [FBrf0216738]
Palanker et al., 2009, Cell Metab. 9(3): 228--239: Drosophila HNF4 regulates lipid mobilization and beta-oxidation. [FBrf0207462]
Egli et al., 2006, Mol. Cell. Biol. 26(6): 2286--2296: A family knockout of all four Drosophila metallothioneins reveals a central role in copper homeostasis and detoxification. [FBrf0191190]

Supplementary material

The modENCODE Consortium, 2010, Science 330(6012):: DataS14: Gene co-expression clusters. [FBrf0213979]
Mummery-Widmer et al., 2009, Nature 458(7241):: Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Giot et al., 2003, Science 302(5651):: Tables S1 to S7. [FBrf0166452]

Personal communication to FlyBase

Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center: RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510]
Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center: RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327]
FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms.: Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
Ryder, 2004.4.26, Exelixis CG deletion data.: Exelixis CG deletion data. [FBrf0184335]

FlyBase analysis

FlyBase, 1992-, FlyBase curation.: FlyBase curation. [FBrf0105495]

Stock list

Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY.: RNAi stocks available from NIG-FLY. [FBrf0218457]