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FB2021_03, released June 15, 2021

Gene: Dmel\KaiR1D

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General Information
Symbol
Dmel\KaiR1D
Species
D. melanogaster
Name
Kainate-type ionotropic glutamate receptor subunit 1D
Annotation Symbol
CG3822
Feature Type
protein_coding_gene
FlyBase ID
FBgn0038837
Gene Model Status
Current
Stock Availability
5 publicly available
Gene Summary
glutamate channel - kainate family protein - localized to presynaptic terminals of the neuromuscular junction - eya - homeostatic potentiation of synaptic strength (Interactive Fly, KaiR1D )
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

DKaiR1D

Key Links
Genomic Location
Cytogenetic map
93A2-93A2
Sequence location
3R:20,860,187..20,866,231 [-]
Recombination map
3-69
RefSeq locus
NT_033777 REGION:20860187..20866231
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (18 terms)
Molecular Function (6 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables glutamate-gated calcium ion channel activity
inferred from mutant phenotype
(Kiragasi et al., 2017)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
enables glutamate receptor activity
inferred from biological aspect of ancestor with PANTHER:PTN001826301
(assigned by GO_Central )
(Gaudet et al., 2011)
enables kainate selective glutamate receptor activity
inferred from sequence or structural similarity with HGNC:4579
(FlyBase Curators, 2008--)
inferred from sequence or structural similarity
(Littleton and Ganetzky, 2000)
enables ligand-gated ion channel activity
inferred from biological aspect of ancestor with PANTHER:PTN000437926
(assigned by GO_Central )
(Gaudet et al., 2011)
enables signaling receptor activity
inferred from biological aspect of ancestor with PANTHER:PTN000437926
(assigned by GO_Central )
(Gaudet et al., 2011)
enables transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
inferred from biological aspect of ancestor with PANTHER:PTN001826301
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (8 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
involved_in calcium ion import across plasma membrane
inferred from mutant phenotype
(Kiragasi et al., 2017)
acts_upstream_of positive regulation of glutamate secretion, neurotransmission
inferred from mutant phenotype
(Kiragasi et al., 2020)
involved_in positive regulation of neuromuscular synaptic transmission
inferred from mutant phenotype
(Kiragasi et al., 2017)
involved_in positive regulation of synaptic transmission, glutamatergic
inferred from mutant phenotype
(Kiragasi et al., 2020)
involved_in presynaptic modulation of chemical synaptic transmission
inferred from mutant phenotype
(Kiragasi et al., 2020)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in modulation of chemical synaptic transmission
inferred from biological aspect of ancestor with PANTHER:PTN001826301
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in regulation of synaptic activity
inferred from sequence or structural similarity with FLYBASE:GluRIIA; FB:FBgn0004620
(FlyBase Curators, 2008--)
involved_in synaptic transmission, glutamatergic
inferred from biological aspect of ancestor with PANTHER:PTN001826301
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in presynaptic active zone
inferred from direct assay
(Kiragasi et al., 2017)
located_in presynaptic membrane
inferred from mutant phenotype
(Kiragasi et al., 2020)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
is_active_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000437926
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in plasma membrane
inferred from sequence or structural similarity with FLYBASE:GluRIIA; FB:FBgn0004620
(FlyBase Curators, 2008--)
is_active_in postsynaptic membrane
inferred from biological aspect of ancestor with PANTHER:PTN001826301
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
NON-NMDA IONOTROPIC GLUTAMATE RECEPTORS - OTHER -
Other Non-NMDA receptors is a grouping of ionotropic glutamate receptors which are not selectively activated by NMDA and do not fall into the GluRII sub-type expressed at the neuromuscular junction. (Adapted from FBrf0209026).
Summary (Interactive Fly)

glutamate channel - kainate family protein - localized to presynaptic terminals of the neuromuscular junction - eya - homeostatic potentiation of synaptic strength

Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\KaiR1D for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
KaiR1D-RA
FBtr0083987
NM_142668
3607
853
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
KaiR1D-PA
FBpp0083391
95.9
853
7.73
NP_650925
AAF55818
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\KaiR1D using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
transmedullary neuron Tm5c
(Karuppudurai et al., 2014)
Additional Descriptive Data

Quantitative RT-PCR on single GFP-labeled cells showed a low level of KaiR1DJF01873 expression in transmedullary neuron Tm5c compared to the transcript level of VGlut in these cells.

(Karuppudurai et al., 2014)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in presynaptic active zone
inferred from direct assay
(Kiragasi et al., 2017)
located_in presynaptic membrane
inferred from mutant phenotype
(Kiragasi et al., 2020)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\KaiR1D in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB
EMBL-EBI Single Cell Expression Atlas
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 5 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of KaiR1D
Transgenic constructs containing regulatory region of KaiR1D
Aberrations (Deficiencies and Duplications) ( 0 )
Inferred from experimentation ( 0 )
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (18)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\GRIK2
10 of 15
Yes
Yes
Hsap\GRIK1
9 of 15
No
No
Hsap\GRIK3
9 of 15
No
Yes
Hsap\GRIK4
5 of 15
No
No
Hsap\GRIK5
5 of 15
No
No
1  
Hsap\GRIA1
2 of 15
No
No
1  
Hsap\GRIA2
2 of 15
No
No
2  
Hsap\GRIA3
2 of 15
No
No
Hsap\GRID1
2 of 15
No
No
Hsap\GRID2
2 of 15
No
No
Hsap\ENPP2
1 of 15
No
Yes
Hsap\GRIA4
1 of 15
No
No
Hsap\GRIN2A
1 of 15
No
No
Hsap\GRIN2B
1 of 15
No
No
Hsap\GRIN2C
1 of 15
No
No
Hsap\GRIN2D
1 of 15
No
No
Hsap\GRIN3A
1 of 15
No
No
Hsap\GRIN3B
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (17)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Grik2
10 of 15
Yes
Yes
Mmus\Grik1
8 of 15
No
No
Mmus\Grik3
8 of 15
No
Yes
Mmus\Grik5
6 of 15
No
No
Mmus\Grik4
5 of 15
No
No
Mmus\Gria2
2 of 15
No
No
Mmus\Gria3
2 of 15
No
No
Mmus\Grid1
2 of 15
No
No
Mmus\Grid2
2 of 15
No
No
Mmus\Gria1
1 of 15
No
No
2  
Mmus\Gria4
1 of 15
No
No
Mmus\Grin2a
1 of 15
No
No
Mmus\Grin2b
1 of 15
No
No
Mmus\Grin2c
1 of 15
No
No
Mmus\Grin2d
1 of 15
No
No
Mmus\Grin3a
1 of 15
No
No
Mmus\Grin3b
1 of 15
No
No
Rattus norvegicus (Norway rat) (15)
Rnor\Grik2
8 of 13
Yes
Yes
Rnor\Grik3
7 of 13
No
No
Rnor\Grik1
6 of 13
No
No
Rnor\Grik4
5 of 13
No
No
Rnor\Grik5
5 of 13
No
No
Rnor\Grid2
2 of 13
No
No
Rnor\Gria3
1 of 13
No
No
Rnor\Gria4
1 of 13
No
No
Rnor\Grid1
1 of 13
No
Yes
Rnor\Grin2a
1 of 13
No
No
Rnor\Grin2b
1 of 13
No
No
Rnor\Grin2c
1 of 13
No
No
Rnor\Grin2d
1 of 13
No
No
Rnor\Grin3a
1 of 13
No
No
Rnor\Grin3b
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (15)
Xtro\grik1
4 of 12
Yes
No
Xtro\grik2
3 of 12
No
Yes
Xtro\grik5-like.1
3 of 12
No
Yes
Xtro\gria3
2 of 12
No
No
Xtro\grid1
2 of 12
No
No
Xtro\grid2
2 of 12
No
No
Xtro\grik3
2 of 12
No
Yes
Xtro\grik4
2 of 12
No
No
Xtro\gria1
1 of 12
No
No
Xtro\gria4
1 of 12
No
No
Xtro\grik5
1 of 12
No
Yes
Xtro\grin2b
1 of 12
No
No
Xtro\grin2c
1 of 12
No
No
Xtro\grin2d
1 of 12
No
No
Xtro\grin3b
1 of 12
No
No
Danio rerio (Zebrafish) (29)
Drer\grik1a
8 of 15
Yes
No
Drer\grik1b
8 of 15
Yes
No
Drer\LOC100334689
8 of 15
Yes
Yes
Drer\grik4
5 of 15
No
No
Drer\grik2
4 of 15
No
No
Drer\grik5
4 of 15
No
No
Drer\si:ch211-251b21.1
3 of 15
No
Yes
Drer\si:dkey-183j2.10
3 of 15
No
Yes
Drer\gria2b
2 of 15
No
No
Drer\gria3b
2 of 15
No
No
Drer\grid1a
2 of 15
No
No
Drer\grid1b
2 of 15
No
No
Drer\grid2
2 of 15
No
No
Drer\LOC100331381
2 of 15
No
No
Drer\gria1a
1 of 15
No
No
Drer\gria1b
1 of 15
No
No
Drer\gria2a
1 of 15
No
No
Drer\gria3a
1 of 15
No
No
Drer\gria4b
1 of 15
No
No
Drer\grin2aa
1 of 15
No
No
Drer\grin2ab
1 of 15
No
No
Drer\grin2bb
1 of 15
No
No
Drer\grin2ca
1 of 15
No
No
Drer\grin2cb
1 of 15
No
No
Drer\grin2da
1 of 15
No
No
Drer\grin3a
1 of 15
No
No
Drer\grin3ba
1 of 15
No
No
Drer\LOC100149482
1 of 15
No
No
Drer\LOC100537813
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (15)
Cele\glr-5
11 of 15
Yes
Yes
Cele\glr-3
9 of 15
No
Yes
Cele\glr-4
7 of 15
No
Yes
Cele\glr-6
4 of 15
No
Yes
Cele\glr-8
3 of 15
No
Yes
Cele\glr-1
2 of 15
No
No
Cele\glr-2
2 of 15
No
No
Cele\C08B6.5
1 of 15
No
No
Cele\F59E12.8
1 of 15
No
Yes
Cele\glr-7
1 of 15
No
No
Cele\nmr-2
1 of 15
No
No
Cele\spp-22
1 of 15
No
Yes
Cele\T25E4.2
1 of 15
No
Yes
Cele\W02A2.5
1 of 15
No
No
Cele\ZK867.2
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (20)
Atha\GLR3.6
6 of 9
Yes
Yes
Atha\GLR2
5 of 9
No
Yes
Atha\GLR3.3
5 of 9
No
No
Atha\GLR3.4
5 of 9
No
No
Atha\GLR3.5
5 of 9
No
No
Atha\GLR5
5 of 9
No
No
Atha\GLUR2
5 of 9
No
No
Atha\ATGLR1.2
4 of 9
No
Yes
Atha\GLR1.1
4 of 9
No
Yes
Atha\GLR1.3
4 of 9
No
Yes
Atha\GLR1.4
4 of 9
No
Yes
Atha\GLR2.4
4 of 9
No
Yes
Atha\GLR2.1
3 of 9
No
Yes
Atha\GLR2.2
3 of 9
No
Yes
Atha\GLR2.3
3 of 9
No
Yes
Atha\GLR2.5
3 of 9
No
Yes
Atha\GLR2.6
3 of 9
No
Yes
Atha\GLR2.7
3 of 9
No
Yes
Atha\GLR2.8
3 of 9
No
Yes
Atha\GLR2.9
3 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091902EC )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila simulans
Dsim\GD20025
Drosophila sechellia
Dsec\GM23151
Drosophila erecta
Dere\GG15059
Drosophila yakuba
Dyak\GE25031
Drosophila yakuba
Dyak\GE27525
Drosophila ananassae
Dana\GF17009
Drosophila pseudoobscura pseudoobscura
Dpse\GA17711
Drosophila persimilis
Dper\GL23254
Drosophila willistoni
Dwil\GK22690
Drosophila virilis
Dvir\GJ24267
Drosophila mojavensis
Dmoj\GI22149
Drosophila grimshawi
Dgri\GH17276
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501GJ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17009306
Musca domestica
House fly
Mdoa\17023070
Musca domestica
House fly
Mdoa\17004263
Glossina morsitans
Tsetse fly
Gmor\GMOY004222
Glossina morsitans
Tsetse fly
Gmor\GMOY006490
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_12027
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_07882
Mayetiola destructor
Hessian fly
Mdes\Mdes010823
Mayetiola destructor
Hessian fly
Mdes\Mdes015152
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL002518
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL002506
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL002538
Anopheles darlingi
American malaria mosquito
Adar\ADAC007349
Anopheles gambiae
Malaria mosquito
Agam\GLURIIb
Anopheles gambiae
Malaria mosquito
Agam\GLURIIe
Anopheles gambiae
Malaria mosquito
Agam\GLURIIa
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ018689
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01QX )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA009564
Bombyx mori
Silkmoth
Bmor\BGIBMGA009597
Bombyx mori
Silkmoth
Bmor\BGIBMGA011486
Bombyx mori
Silkmoth
Bmor\BGIBMGA011528
Danaus plexippus
Monarch butterfly
Dple\DPOGS213730-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS209173-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS215109-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS213732-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL015522
Heliconius melpomene
Postman butterfly
Hmel\HMEL017170
Heliconius melpomene
Postman butterfly
Hmel\HMEL013710
Heliconius melpomene
Postman butterfly
Hmel\HMEL004580
Apis florea
Little honeybee
Aflo\3156287700
Apis florea
Little honeybee
Aflo\4590677124
Apis florea
Little honeybee
Aflo\2147533299
Apis florea
Little honeybee
Aflo\3780165908
Apis florea
Little honeybee
Aflo\3022081892
Apis mellifera
Western honey bee
Amel\GB49268
Apis mellifera
Western honey bee
Amel\GB53122
Apis mellifera
Western honey bee
Amel\GB53118
Apis mellifera
Western honey bee
Amel\GB49273
Apis mellifera
Western honey bee
Amel\GB49275
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP24960
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP21318
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP24114
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP24961
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP24105
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP21738
Bombus terrestris
Buff-tailed bumblebee
Bter\15215897
Bombus terrestris
Buff-tailed bumblebee
Bter\15205451
Bombus terrestris
Buff-tailed bumblebee
Bter\15205452
Bombus terrestris
Buff-tailed bumblebee
Bter\15215888
Bombus terrestris
Buff-tailed bumblebee
Bter\15205453
Linepithema humile
Argentine ant
Lhum\LH24045
Linepithema humile
Argentine ant
Lhum\LH20394
Linepithema humile
Argentine ant
Lhum\LH24044
Linepithema humile
Argentine ant
Lhum\LH15649
Linepithema humile
Argentine ant
Lhum\LH15650
Linepithema humile
Argentine ant
Lhum\LH15651
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0022bc
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002bd4
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0022bf
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002bcc
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0022bd
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG010011
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG018970
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG010019
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_07381
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_12929
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_07839
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_07382
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_12931
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_08566
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_10387
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_08568
Tribolium castaneum
Red flour beetle
Tcas\TC033173
Tribolium castaneum
Red flour beetle
Tcas\TC032202
Tribolium castaneum
Red flour beetle
Tcas\TC012818
Tribolium castaneum
Red flour beetle
Tcas\TC032415
Tribolium castaneum
Red flour beetle
Tcas\TC003560
Tribolium castaneum
Red flour beetle
Tcas\TC032203
Tribolium castaneum
Red flour beetle
Tcas\TC031399
Pediculus humanus
Human body louse
Phum\PHUM253980
Pediculus humanus
Human body louse
Phum\PHUM518040
Pediculus humanus
Human body louse
Phum\PHUM570680
Pediculus humanus
Human body louse
Phum\PHUM518050
Pediculus humanus
Human body louse
Phum\PHUM536820
Rhodnius prolixus
Kissing bug
Rpro\RPRC000199
Rhodnius prolixus
Kissing bug
Rpro\RPRC000021
Rhodnius prolixus
Kissing bug
Rpro\RPRC010182
Rhodnius prolixus
Kissing bug
Rpro\RPRC000154
Rhodnius prolixus
Kissing bug
Rpro\RPRC002040
Rhodnius prolixus
Kissing bug
Rpro\RPRC010372
Cimex lectularius
Bed bug
Clec\CLEC006915
Cimex lectularius
Bed bug
Clec\CLEC001553
Cimex lectularius
Bed bug
Clec\CLEC006914
Cimex lectularius
Bed bug
Clec\CLEC006916
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI006027
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI008906
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI071399
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI004687
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI060830
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI006975
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_19052
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_05107
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_19051
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_18949
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0764 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR000906
Strigamia maritima
European centipede
Smar\SMAR013852
Strigamia maritima
European centipede
Smar\SMAR000902
Strigamia maritima
European centipede
Smar\SMAR006430
Ixodes scapularis
Black-legged tick
Isca\ISCW008266
Ixodes scapularis
Black-legged tick
Isca\ISCW001842
Ixodes scapularis
Black-legged tick
Isca\ISCW023274
Ixodes scapularis
Black-legged tick
Isca\ISCW012402
Stegodyphus mimosarum
African social velvet spider
Smim\KFM59945.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM75325.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM57371.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM83024.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM81343.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM81344.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM73260.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM75323.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur06g03760
Tetranychus urticae
Two-spotted spider mite
Turt\tetur12g00180
Tetranychus urticae
Two-spotted spider mite
Turt\tetur09g02270
Tetranychus urticae
Two-spotted spider mite
Turt\tetur07g05440
Tetranychus urticae
Two-spotted spider mite
Turt\tetur07g06860
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g01930
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_55220
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_327119
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_55388
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_309661
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G02LN )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Glur6_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Glur6
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Grik3
Ciona intestinalis
Vase tunicate
Cint\LOC100175916
Gallus gallus
Domestic chicken
Ggal\GRIK1
Gallus gallus
Domestic chicken
Ggal\GRIK4
Gallus gallus
Domestic chicken
Ggal\GRIK3
Gallus gallus
Domestic chicken
Ggal\GRIK2
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (37)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Grik
7 of 10
CG11155
6 of 10
clumsy
6 of 10
Ekar
6 of 10
GluRIID
6 of 10
GluRIIE
6 of 10
GluRIA
4 of 10
GluRIB
3 of 10
GluRIIA
3 of 10
GluRIIB
3 of 10
GluRIIC
3 of 10
Ir25a
3 of 10
Nmdar2
3 of 10
Ir8a
2 of 10
Ir21a
2 of 10
Ir31a
2 of 10
Ir64a
2 of 10
Ir75a
2 of 10
Ir75c
2 of 10
Ir75d
2 of 10
Ir76b
2 of 10
Ir84a
2 of 10
Ir93a
2 of 10
Nmdar1
2 of 10
Ir7a
1 of 10
Ir7b
1 of 10
Ir7c
1 of 10
Ir7d
1 of 10
Ir7e
1 of 10
Ir7f
1 of 10
Ir7g
1 of 10
Ir11a
1 of 10
Ir60a
1 of 10
Ir68a
1 of 10
Ir75b
1 of 10
Ir85a
1 of 10
Ir87a
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    GRIK2; glutamate ionotropic receptor kainate type subunit 2
    10 of 15
    138244
    GRIK1; glutamate ionotropic receptor kainate type subunit 1
    9 of 15
    138245
        GRIK3; glutamate ionotropic receptor kainate type subunit 3
        9 of 15
        138243
            GRIK4; glutamate ionotropic receptor kainate type subunit 4
            5 of 15
            600282
                GRIK5; glutamate ionotropic receptor kainate type subunit 5
                5 of 15
                600283
                     
                    Functional Complementation Data
                    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                    Interactions
                    Summary of Physical Interactions
                    esyN Network Diagram
                    Show neighbor-neighbor interactions:
                    Select Layout:
                    Legend:
                    Protein
                    RNA
                    Selected Interactor(s)
                    Interactions Browser
                    View in Interactions Browser
                    Please see the Physical Interaction reports below for full details
                    RNA-protein
                    Physical Interaction
                    Assay
                    References
                    KaiR1D - CG44249
                    anti tag coimmunoprecipitation, reverse transcription pcr
                    (Li et al., 2020)
                    Summary of Genetic Interactions
                    esyN Network Diagram
                    esyN Network Key:
                    Suppression
                    Enhancement
                    View in Interactions Browser
                    Please look at the allele data for full details of the genetic interactions
                    Starting gene(s)
                    Interaction type
                    Interacting gene(s)
                    Reference
                    KaiR1D
                    enhanceable
                    VGlut
                    (Kiragasi et al., 2017)
                    Starting gene(s)
                    Interaction type
                    Interacting gene(s)
                    Reference
                    GluRIIA
                    suppressible
                    KaiR1D
                    (Kiragasi et al., 2017)
                    Sol1
                    suppressible
                    KaiR1D
                    (Kiragasi et al., 2020)
                    VGlut
                    enhanceable
                    KaiR1D
                    (Kiragasi et al., 2017)
                    External Data
                    Linkouts
                    DroID - A comprehensive database of gene and protein interactions.
                    Pathways
                    Signaling Pathways (FlyBase)
                    Metabolic Pathways
                    External Data
                    Linkouts
                    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                    Genomic Location and Detailed Mapping Data
                    Chromosome (arm)
                    3R
                    Recombination map
                    3-69
                    Cytogenetic map
                    93A2-93A2
                    Sequence location
                    3R:20,860,187..20,866,231 [-]
                    FlyBase Computed Cytological Location
                    Cytogenetic map
                    Evidence for location
                    93A2-93A2
                    Limits computationally determined from genome sequence between P{EP}SyndEP409 and P{lacW}l(3)j5C7j5C7
                    Experimentally Determined Cytological Location
                    Cytogenetic map
                    Notes
                    References
                    Experimentally Determined Recombination Data
                    Location

                    3-69

                    (FlyBase, 2016)

                    3-73.0

                    (Comeron et al., 2012)
                    Left of (cM)
                    Right of (cM)
                    Notes
                    Stocks and Reagents
                    Stocks (5)
                    Genomic Clones (23)
                    cDNA Clones (65)
                     

                    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                    cDNA clones, fully sequenced
                    BDGP DGC clones
                    Other clones
                      Drosophila Genomics Resource Center cDNA clones

                      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                      cDNA Clones, End Sequenced (ESTs)
                      BDGP DGC clones
                        Other clones
                        RNAi and Array Information
                        Linkouts
                        DRSC - Results frm RNAi screens
                        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                        Antibody Information
                        Laboratory Generated Antibodies
                         

                        polyclonal

                        (Kiragasi et al., 2017)
                        Commercially Available Antibodies
                         
                        Other Information
                        Relationship to Other Genes
                        Source for database identify of

                        Source for identity of: KaiR1D CG3822

                        (Kiragasi et al., 2017)
                        Source for database merge of
                        Additional comments
                        Other Comments
                        Origin and Etymology
                        Discoverer
                        Etymology

                        The gene is named 'KaiR1D' based on function and phylogenetic analysis.

                        (Kiragasi et al., 2017)
                        Identification
                        External Crossreferences and Linkouts ( 40 )
                        Sequence Crossreferences
                        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                        Other crossreferences
                        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                        DRscDB
                        EMBL-EBI Single Cell Expression Atlas
                        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                        Flygut - An atlas of the Drosophila adult midgut
                        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                        InterPro - A database of protein families, domains and functional sites
                        KEGG Genes - Molecular building blocks of life in the genomic space.
                        MARRVEL_MODEL
                        modMine - A data warehouse for the modENCODE project
                        Linkouts
                        DroID - A comprehensive database of gene and protein interactions.
                        DRSC - Results frm RNAi screens
                        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                        FlyMine - An integrated database for Drosophila genomics
                        Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                        Synonyms and Secondary IDs (9)
                        Datasets (0)
                        Study focus (0)
                        Experimental Role
                        Project
                        Project Type
                        Title
                        References (45)