FB2019_06, released Dec 19, 2019

Gene: Dmel\Burs

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General Information
Symbol
Dmel\Burs
Species
D. melanogaster
Name
Bursicon
Annotation Symbol
CG13419
Feature Type
protein_coding_gene
FlyBase ID
FBgn0038901
Gene Model Status
Current
Stock Availability
8 publicly available
Gene Snapshot
Bursicon (Burs) encodes a cystine knot protein that dimerizes with the product of Pburs to form the bursicon neurohormone. Bursicon neurohormone is released after adult emergence and acts on the receptor encoded by rk for tanning and hardening of the cuticle and expansion of the wings. [Date last reviewed: 2019-03-07]
Other Summaries
Also Known As
bursicon α, bursα, burs α, bursicon α-subunit
Key Links
Genomic Location
Cytogenetic map
93F9-93F9
Sequence location
3R:21,769,518..21,770,279 [+]
Recombination map
3-73
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
hormone activity; contributes_to neuropeptide hormone activity; contributes_to neuropeptide receptor binding; protein heterodimerization activity
Predictions / Assertions
contributes_to neuropeptide hormone activity
Summaries
Gene Group (FlyBase)
NEUROPEPTIDES -
Neuropeptides are secreted into the extracellular space where they interact with cell surface receptors (usually G protein coupled receptors). They are extremely diverse, acting as neurotransmitters, neuromodulators, hormones or growth factors. (Adapted from FBrf0211443 and PMID:27813667).
Protein Function (UniProtKB)
Final heterodimeric neurohormone released at the end of the molting cycle, involved in the sclerotization (tanning) of the insect cuticle, melanization and wing spreading. Heterodimer specifically activates the G protein-coupled receptor rk.
(UniProt, Q9VD83)
Summary (Interactive Fly)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\Burs or the JBrowse view of Dmel\Burs for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.49
Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Burs-RA
FBtr0084131
NM_142726
640
173
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Burs-PA
FBpp0083529
19.2
173
7.78
NP_650983
AAF55915
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
antibody probe was IgYs harvested from egg yolks of chicken immunized and boosted with synthetic Drosophila Burs peptide (sequences 91â 108)
(Dewey et al., 2004)
External Data
Subunit Structure (UniProtKB)
Heterodimer of Burs and Pburs.
(UniProt, Q9VD83)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Burs using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (12 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
hormone activity
inferred from mutant phenotype
(assigned by UniProt )
(Dewey et al., 2004)
contributes_to neuropeptide hormone activity
inferred from direct assay
(Luo et al., 2005)
contributes_to neuropeptide receptor binding
inferred from physical interaction with FLYBASE:rk; FB:FBgn0003255
(Luo et al., 2005)
protein heterodimerization activity
inferred from physical interaction with UniProtKB:Q9VJS7
(assigned by UniProt )
(Mendive et al., 2005)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
contributes_to neuropeptide hormone activity
inferred by curator from GO:0031395
(Mendive et al., 2005)
Biological Process (5 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
border follicle cell delamination
inferred from mutant phenotype
(Anllo and Schüpbach, 2016)
border follicle cell migration
inferred from mutant phenotype
(Anllo and Schüpbach, 2016)
chitin-based cuticle sclerotization
inferred from mutant phenotype
(assigned by UniProt )
(Dewey et al., 2004)
cuticle pigmentation
inferred from mutant phenotype
(assigned by UniProt )
(Dewey et al., 2004)
intestinal stem cell homeostasis
inferred from mutant phenotype
(Scopelliti et al., 2014)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
bursicon neuropeptide hormone complex
inferred from physical interaction with FLYBASE:Pburs; FB:FBgn0264810
(Luo et al., 2005)
inferred from direct assay
(Mendive et al., 2005)
extracellular region
inferred from direct assay
(assigned by UniProt )
(Dewey et al., 2004)
terminal bouton
inferred from direct assay
(Loveall and Deitcher, 2010)
Terms Based on Predictions or Assertions (0 terms)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
ventral nerve cord | restricted
(Dewey et al., 2004)
pharate adult stage P8 -- pharate adult stage P15(ii)
neuron | subset of ventral nerve cord
(Lahr et al., 2012)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
early third instar larval stage -- adult stage
organism
(Luo et al., 2005)
adult stage
adult midgut
(Scopelliti et al., 2014)
adult brain | restricted
(Scopelliti et al., 2014)
pharate adult stage P15
adult brain | restricted
(Scopelliti et al., 2014)
Additional Descriptive Data
burs transcript is detected in several pairs of neurons in the pharate pupae ventral nerve cord. Strong expression is detected in one neuron in each T3 and A6 segments and 2 neurons in segments A1 to A5. All of these neurons also express CCAP transcript, and one neuron in each A1-A4 segments co-expresses pburs transcript. Expression of burs transcript is very similar to the expression of burs protein.
(Lahr et al., 2012)
RT-PCR analysis indicates that burs transcript levels are low in the third larval stage, gradually increasing during pupal stages and reaching the highest levels in pharate adults. Levels are low in adults.
(Luo et al., 2005)
expressed in cells which also express CCAP.
(Dewey et al., 2004)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
distribution deduced from reporter (Gal4 UAS)
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
neuron | subset of adult brain
(Ma et al., 2012)
subesophageal ganglion neuron | subset
(Ma et al., 2012)
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
neuron | subset of embryonic/larval brain
(Hari et al., 2008)
neuron | subset of ventral nerve cord
(Hari et al., 2008, Peabody et al., 2008)
ventral nerve cord | restricted
(Dewey et al., 2004)
subesophageal ganglion neuron | subset
(Peabody et al., 2008)
neuron | subset of larval mesothoracic segment
(Peabody et al., 2008)
neuron | subset of larval metathoracic segment
(Peabody et al., 2008)
neuron | subset of larval prothoracic segment
(Peabody et al., 2008)
neuron | subset of abdominal neuromere
(Peabody et al., 2008)
peptidergic neuron | subset of ventral nerve cord
(Lee et al., 2013)
adult stage
neuron | subset of abdominal neuromere
(Peabody et al., 2008)
neuron | subset of adult gnathal ganglion
(Peabody et al., 2008)
peptidergic neuron | subset of thoracico-abdominal ganglion

Comment: 0-18h after eclosion

(Lee et al., 2013)
enteroendocrine cell of posterior adult midgut epithelium

Comment: 50% of enteroendocrine cells in midgut

(Scopelliti et al., 2014)
prepupal stage P2
corpus cardiacum
(Honegger et al., 2002)
pharate adult stage P8 -- pharate adult stage P15(ii)
neuron | subset of ventral nerve cord
(Lahr et al., 2012)
wandering third instar larval stage
type III bouton
(Loveall and Deitcher, 2010)
embryonic/larval neuromuscular junction
(Loveall and Deitcher, 2010)
Additional Descriptive Data
Burs-protein is expressed in a subset of peptidergic neurons in the larval ventral nerve cord. Directly after eclosion expression is detected in around 14 neurons in the posterior part of the thoracico-abdominal ganglion. This number decreases to zero over the first day after eclosion.
(Lee et al., 2013)
burs protein is detected in several pairs of neurons in the pharate pupae ventral nerve cord. Strong expression is detected in one neuron in each T3, A5-A7 segments and 2 neurons in segments A1 to A4. All of these neurons also express CCAP transcript, and one neuron in each A1-A4 segments co-expresses pburs transcript. Expression of burs protein is very similar to the expression of burs transcript.
(Lahr et al., 2012)
burs protein is expressed in a subset of CCAP neurons labeled with Scer\GAL4CCAP.PP in the adult brain, including neurons in the subesophageal ganglion that extend their axons along the midline to the anterior brain.
(Ma et al., 2012)
In the larval ventral nerve cord, burs is prominently expressed in: two prominent pairs of neurons in the subesophageal ganglion; one pair of neurons in each of the first two thoracic neuromeres and two pairs in the third; two pairs of neurons in each of the first four abdominal neuromeres, and one to two pairs in the remaining abdominal neuromeres. In the adult, burs is expressed in a bilateral pair of neurons in the subesophageal ganglion, and in seven bilaterally paired neurons of the third thoracic neuromere and the abdominal ganglion.
(Peabody et al., 2008)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
bursicon neuropeptide hormone complex
inferred from physical interaction with FLYBASE:Pburs; FB:FBgn0264810
(Luo et al., 2005)
inferred from direct assay
(Mendive et al., 2005)
extracellular region
inferred from direct assay
(assigned by UniProt )
(Dewey et al., 2004)
terminal bouton
inferred from direct assay
(Loveall and Deitcher, 2010)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Burs in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 6 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Burs
Transgenic constructs containing regulatory region of Burs
Deletions and Duplications ( 6 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal - all die before end of P-stage, with Scer\GAL4Act5C.PI
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
Other Phenotypes
Allele
cell migration defective | adult stage | female
cell migration defective | adult stage | female, with Scer\GAL4slbo.2.6, Scer\GAL4upd1.PU
decreased cell number | adult stage, with Scer\GAL4pros-V1
decreased occurrence of cell division | adult stage, with Scer\GAL4pros-V1
increased cell number | adult stage, with Scer\GAL4pros-V1
increased cell number | adult stage | dominant
increased occurrence of cell division | adult stage
increased occurrence of cell division | adult stage, with Scer\GAL4pros-V1
locomotor rhythm defective | adult stage, with Scer\GAL4elav-C155
mating behavior defective | mated female, with Scer\GAL4nSyb.PU
some die during pharate adult stage, with Scer\GAL4Act5C.PI
visible, with Scer\GAL4Act5C.PI
visible, with Scer\GAL4Burs.PP
visible, with Scer\GAL4Toll-6-D42
visible (with BursZ1091)
visible (with BursZ5569)
visible | recessive
Phenotype manifest in
Allele
adult abdomen
adult abdomen (with BursZ1091)
adult abdomen (with BursZ5569)
adult cuticle
adult cuticle (with BursZ1091)
adult cuticle (with BursZ5569)
adult midgut
adult midgut, with Scer\GAL4pros-V1
adult thorax
border follicle cell
border follicle cell, with Scer\GAL4slbo.2.6, Scer\GAL4upd1.PU
intestinal stem cell | adult stage
intestinal stem cell | adult stage, with Scer\GAL4pros-V1
posterior scutellar bristle
posterior scutellar bristle (with BursZ1091)
posterior scutellar bristle (with BursZ5569)
wing
wing, with Scer\GAL4Act5C.PI
wing, with Scer\GAL4Burs.PP
wing, with Scer\GAL4Toll-6-D42
wing (with BursZ1091)
wing (with BursZ5569)
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (0)
No records found.
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Muc5b
1 of 15
Yes
No
Rattus norvegicus (Norway rat) (0)
No records found.
Xenopus tropicalis (Western clawed frog) (0)
No records found.
Danio rerio (Zebrafish) (0)
No records found.
Caenorhabditis elegans (Nematode, roundworm) (0)
No records found.
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190GEJ )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\Burs
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00012212
Drosophila simulans
Dsim\GD20896
Drosophila sechellia
Dsec\GM26374
Drosophila erecta
Dere\GG11041
Drosophila erecta
Dere\GG17481
Drosophila yakuba
Dyak\GE10240
Drosophila ananassae
Dana\GF18044
Drosophila pseudoobscura pseudoobscura
Dpse\GA12271
Drosophila persimilis
Dper\GL23793
Drosophila willistoni
Dwil\GK12896
Drosophila virilis
Dvir\GJ23072
Drosophila mojavensis
Dmoj\GI24294
Drosophila grimshawi
Dgri\GH18623
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150GVO )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17016419
Glossina morsitans
Tsetse fly
Gmor\GMOY011521
Mayetiola destructor
Hessian fly
Mdes\Mdes011000
Anopheles gambiae
Malaria mosquito
Agam\burs3
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ009600
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0LM2 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\pburs
Danaus plexippus
Monarch butterfly
Dple\DPOGS203171-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS203172-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL005791
Heliconius melpomene
Postman butterfly
Hmel\HMEL005789
Apis florea
Little honeybee
Aflo\2922430436
Apis florea
Little honeybee
Aflo\2147561635
Apis mellifera
Western honey bee
Amel\burs
Apis mellifera
Western honey bee
Amel\GB45445
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP18661
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP18662
Bombus terrestris
Buff-tailed bumblebee
Bter\15203033
Linepithema humile
Argentine ant
Lhum\LH12242
Linepithema humile
Argentine ant
Lhum\LH12247
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0030af
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0030b0
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG037268
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG023182
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_03610
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_03609
Tribolium castaneum
Red flour beetle
Tcas\pburs
Tribolium castaneum
Red flour beetle
Tcas\burs
Pediculus humanus
Human body louse
Phum\PHUM498600
Pediculus humanus
Human body louse
Phum\PHUM498610
Rhodnius prolixus
Kissing bug
Rpro\RPRC000797
Cimex lectularius
Bed bug
Clec\CLEC011727
Cimex lectularius
Bed bug
Clec\CLEC011726
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI005281
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI007165
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_13408
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_13409
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0LTT )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR014102
Strigamia maritima
European centipede
Smar\SMAR013675
Ixodes scapularis
Black-legged tick
Isca\ISCW004618
Ixodes scapularis
Black-legged tick
Isca\ISCW004617
Stegodyphus mimosarum
African social velvet spider
Smim\KFM75850.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM75851.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur08g03250
Tetranychus urticae
Two-spotted spider mite
Turt\tetur28g01650
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g05570
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_312013
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_43247
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0ZCB )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Bursiconb
Strongylocentrotus purpuratus
Purple sea urchin
Spur\burs-alpha-like
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser
    View in Interactions Browser
    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    Burs
    comigration in non denaturing gel electrophoresis, western blot, confirmation by molecular weight
    (An et al., 2012)
    Burs - Pburs
    comigration in non denaturing gel electrophoresis, western blot, confirmation by molecular weight, molecular sieving, molecular weight estimation by staining
    (An et al., 2012, Mendive et al., 2005)
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement
    View in Interactions Browser
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Burs
    suppressible
    Egfr
    (Scopelliti et al., 2014)
    Burs
    suppressible
    vn
    (Scopelliti et al., 2014)
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Subunit Structure (UniProtKB)
    Heterodimer of Burs and Pburs.
    (UniProt, Q9VD83 )
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3R
    Recombination map
    3-73
    Cytogenetic map
    93F9-93F9
    Sequence location
    3R:21,769,518..21,770,279 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    93F9-93F9
    Limits computationally determined from genome sequence between P{PZ}InR05545 and P{PZ}tsl00617
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location
    3-73
    (FlyBase, 2016)
    3-74.8
    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (8)
    Genomic Clones (17)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (2)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
      Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
        Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          Antibody Information
          Laboratory Generated Antibodies
           
          polyclonal
          (Luan et al., 2006, Luo et al., 2005, Dewey et al., 2004, Honegger et al., 2002)
          Commercially Available Antibodies
           
          Other Information
          Relationship to Other Genes
          Source for database identify of
          Source for identity of: bursicon CG13419
          (McNabb et al., 2004)
          Source for identity of: Burs burs
          (FlyBase, 2009-)
          Source for database merge of
          Source for merge of: burs frl
          (Kiger, 2004.3.17)
          Additional comments
          Other Comments
          The rk receptor and its signal Burs appear to be involved in intercellular communication within the border follicle cell cluster itself during border cell migration, as the Burs signal is only required in the border cells.
          (Anllo and Schüpbach, 2016)
          Bioactive D.melanogaster bursicon is a heterodimer composed of the burs and pburs polypeptides. burs protein by itself does not have bursicon bioactivity.
          (Mendive et al., 2005)
          Mutants block delamination, migration and bonding of cuticle layers during wing maturation.
          (Kiger et al., 2004)
          Origin and Etymology
          Discoverer
          Etymology
          Identification
          External Crossreferences and Linkouts ( 25 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
          Other crossreferences
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          Flygut - An atlas of the Drosophila adult midgut
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          modMine - A data warehouse for the modENCODE project
          Linkouts
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          FLIGHT - Cell culture data for RNAi and other high-throughput technologies
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          FlyMine - An integrated database for Drosophila genomics
          Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
          Synonyms and Secondary IDs (20)
          Reported As
          Symbol Synonym
          BURS
          (Loveall and Deitcher, 2010, Nässel and Winther, 2010, Davis et al., 2007)
          Bur α
          (Harwood et al., 2013)
          Burs
          (Zhang and Zhou, 2019, Donlea et al., 2018, Liu and Jin, 2017, Transgenic RNAi Project members, 2017-, Chen et al., 2016, Jiang et al., 2016, Lee et al., 2015, Hwang et al., 2014, Asahina and Anderson, 2013.9.23)
          Burs α
          (Nässel and Winther, 2010)
          Burs-α
          (Harwood et al., 2014)
          Bursα
          (Veverytsa and Allan, 2011, McNabb and Truman, 2006)
          CG13419
          (Asahina and Anderson, 2013.9.23, Colca et al., 2013, Lemaitre and Miguel-Aliaga, 2013, Keleman et al., 2009.8.5, Perkins et al., 2009.3.31, An et al., 2008, Natzle et al., 2008, Luan et al., 2006, McNabb and Truman, 2006, Mendive et al., 2005, Davis, 2003, Davis, 2001.10.11)
          burs
          (Scopelliti et al., 2016, Scopelliti et al., 2014, Lee et al., 2013, Lemaitre and Miguel-Aliaga, 2013, Marianes and Spradling, 2013, Japanese National Institute of Genetics, 2012.5.21, Lahr et al., 2012, Gatto and Broadie, 2011, Nässel and Winther, 2010, Hari et al., 2008, Natzle et al., 2008, Peabody et al., 2008, Davis et al., 2007, Peabody et al., 2007, Bowser and Tobe, 2006, Luo et al., 2005)
          burs alpha
          (Anllo and Schüpbach, 2016)
          burs α
          (An et al., 2012, Hari et al., 2008)
          burs-alpha
          (VandenBroeck, 2004.11.9)
          bursα
          (Scopelliti et al., 2019, Luan et al., 2006, Mendive et al., 2005)
          frl
          Name Synonyms
          Bursicon
          (Nässel, 2018, Steyaert et al., 2018, Asahina et al., 2014, Hwang et al., 2014, Asahina and Anderson, 2013.9.23, Caers et al., 2012, Gatto and Broadie, 2011, Nässel and Winther, 2010, Veenstra et al., 2008)
          Bursicon α subunit
          (Nässel and Winther, 2010)
          bursicon
          (Bilousov et al., 2013, Lee et al., 2013, Gatto and Broadie, 2011, Loveall and Deitcher, 2010, Natzle et al., 2008, Peabody et al., 2008, Zhao et al., 2008, Davis et al., 2007, Davis et al., 2007, Kim et al., 2006, Luan et al., 2006, Honegger et al., 2002)
          bursicon α
          (An et al., 2012, Ma et al., 2012, Gatto and Broadie, 2011, An et al., 2008, Zhao et al., 2008, Mendive et al., 2005)
          bursicon α subunit
          (Gatto and Broadie, 2011)
          bursicon α-subunit
          (Chen et al., 2014, Luan et al., 2006)
          furled wing
          (Kiger, 2004.3.4)
          Secondary FlyBase IDs
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            References (96)