bursicon α, bursα, bursicon α-subunit, burs α
Gene model reviewed during 5.49
There is only one protein coding transcript and one polypeptide associated with this gene
Heterodimer of Burs and Pburs.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Burs using the Feature Mapper tool.
Burs transcripts are highly enriched in adult midgut and are undetectable in the adult CNS.
burs transcript is detected in several pairs of neurons in the pharate pupae ventral nerve cord. Strong expression is detected in one neuron in each T3 and A6 segments and 2 neurons in segments A1 to A5. All of these neurons also express CCAP transcript, and one neuron in each A1-A4 segments co-expresses pburs transcript. Expression of burs transcript is very similar to the expression of burs protein.
RT-PCR analysis indicates that burs transcript levels are low in the third larval stage, gradually increasing during pupal stages and reaching the highest levels in pharate adults. Levels are low in adults.
Comment: 50% of enteroendocrine cells in midgut
Burs-protein is expressed in a subset of peptidergic neurons in the larval ventral nerve cord. Directly after eclosion expression is detected in around 14 neurons in the posterior part of the thoracico-abdominal ganglion. This number decreases to zero over the first day after eclosion.
burs protein is detected in several pairs of neurons in the pharate pupae ventral nerve cord. Strong expression is detected in one neuron in each T3, A5-A7 segments and 2 neurons in segments A1 to A4. All of these neurons also express CCAP transcript, and one neuron in each A1-A4 segments co-expresses pburs transcript. Expression of burs protein is very similar to the expression of burs transcript.
burs protein is expressed in a subset of CCAP neurons labeled with Scer\GAL4CCAP.PP in the adult brain, including neurons in the subesophageal ganglion that extend their axons along the midline to the anterior brain.
In the larval ventral nerve cord, burs is prominently expressed in: two prominent pairs of neurons in the subesophageal ganglion; one pair of neurons in each of the first two thoracic neuromeres and two pairs in the third; two pairs of neurons in each of the first four abdominal neuromeres, and one to two pairs in the remaining abdominal neuromeres. In the adult, burs is expressed in a bilateral pair of neurons in the subesophageal ganglion, and in seven bilaterally paired neurons of the third thoracic neuromere and the abdominal ganglion.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Burs in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
The rk receptor and its signal Burs appear to be involved in intercellular communication within the border follicle cell cluster itself during border cell migration, as the Burs signal is only required in the border cells.
Mutants block delamination, migration and bonding of cuticle layers during wing maturation.