FlyBase Gene Report: Dmel\Burs

General Information

Symbol

Dmel\Burs

Species

D. melanogaster

Name

Bursicon

Annotation Symbol

CG13419

Feature Type

protein_coding_gene

FlyBase ID

FBgn0038901

Gene Model Status

Current

Stock Availability

8 publicly available

Gene Summary

Bursicon (Burs) encodes a cystine knot protein that dimerizes with the product of Pburs to form the bursicon neurohormone. Bursicon neurohormone is released after adult emergence and acts on the receptor encoded by rk for tanning and hardening of the cuticle and expansion of the wings. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

bursicon α, bursα, burs α, bursicon α-subunit

Key Links

Genomic Location

Cytogenetic map

93F9-93F9

Sequence location

3R:21,769,518..21,770,279 [+]

Recombination map

3-73

RefSeq locus

NT_033777 REGION:21769518..21770279

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (12 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

enables hormone activity

inferred from mutant phenotype

(assigned by UniProt )

(Dewey et al., 2004)

contributes_to neuropeptide hormone activity

inferred from direct assay

(Luo et al., 2005)

contributes_to neuropeptide receptor binding

inferred from physical interaction with FLYBASE:rk; FB:FBgn0003255

(Luo et al., 2005)

enables protein heterodimerization activity

inferred from physical interaction with UniProtKB:Q9VJS7

(assigned by UniProt )

(Mendive et al., 2005)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

contributes_to neuropeptide hormone activity

inferred by curator from GO:0031395

(Mendive et al., 2005)

Biological Process (5 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

involved_in border follicle cell delamination

inferred from mutant phenotype

(Anllo and Schüpbach, 2016)

involved_in border follicle cell migration

inferred from mutant phenotype

(Anllo and Schüpbach, 2016)

involved_in chitin-based cuticle sclerotization

inferred from mutant phenotype

(assigned by UniProt )

(Dewey et al., 2004)

involved_in cuticle pigmentation

inferred from mutant phenotype

(assigned by UniProt )

(Dewey et al., 2004)

involved_in intestinal stem cell homeostasis

inferred from mutant phenotype

(Scopelliti et al., 2014)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

part_of bursicon neuropeptide hormone complex

inferred from direct assay

(Mendive et al., 2005)

inferred from physical interaction with FLYBASE:Pburs; FB:FBgn0264810

(Luo et al., 2005)

located_in extracellular region

inferred from direct assay

(assigned by UniProt )

(Dewey et al., 2004)

located_in terminal bouton

inferred from direct assay

(Loveall and Deitcher, 2010)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

NEUROPEPTIDES

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

NEUROPEPTIDES -: Neuropeptides are secreted into the extracellular space where they interact with cell surface receptors (usually G protein coupled receptors). They are extremely diverse, acting as neurotransmitters, neuromodulators, hormones or growth factors. (Adapted from FBrf0211443 and PMID:27813667).

Protein Function (UniProtKB)

Final heterodimeric neurohormone released at the end of the molting cycle, involved in the sclerotization (tanning) of the insect cuticle, melanization and wing spreading. Heterodimer specifically activates the G protein-coupled receptor rk.

(UniProt, Q9VD83)

Summary (Interactive Fly)

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Burs for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.49

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Burs-RA

FBtr0084131

NM_142726

640

173

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Burs-PA

FBpp0083529

19.2

173

7.78

NP_650983

AAF55915

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

antibody probe was IgYs harvested from egg yolks of chicken immunized and boosted with synthetic Drosophila Burs peptide (sequences 91â 108)

(Dewey et al., 2004)

External Data

Subunit Structure (UniProtKB)

Heterodimer of Burs and Pburs.

(UniProt, Q9VD83)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9VD83

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Burs using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Burs_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

larval ventral nerve cord | restricted

(Dewey et al., 2004)

pharate adult stage P8 -- pharate adult stage P15(ii)

neuron | subset of larval ventral nerve cord

(Lahr et al., 2012)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

early third instar larval stage -- adult stage

organism

(Luo et al., 2005)

pharate adult stage P15

adult brain | restricted

(Scopelliti et al., 2014)

adult stage

adult midgut

(Scopelliti et al., 2019, Scopelliti et al., 2014)

adult brain | restricted

(Scopelliti et al., 2014)

Additional Descriptive Data

Burs transcripts are highly enriched in adult midgut and are undetectable in the adult CNS.

(Scopelliti et al., 2019)

burs transcript is detected in several pairs of neurons in the pharate pupae ventral nerve cord. Strong expression is detected in one neuron in each T3 and A6 segments and 2 neurons in segments A1 to A5. All of these neurons also express CCAP transcript, and one neuron in each A1-A4 segments co-expresses pburs transcript. Expression of burs transcript is very similar to the expression of burs protein.

(Lahr et al., 2012)

RT-PCR analysis indicates that burs transcript levels are low in the third larval stage, gradually increasing during pupal stages and reaching the highest levels in pharate adults. Levels are low in adults.

(Luo et al., 2005)

expressed in cells which also express CCAP.

(Dewey et al., 2004)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

distribution deduced from reporter (Gal4 UAS)

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

neuron | subset of adult brain

(Ma et al., 2012)

subesophageal ganglion neuron | subset

(Ma et al., 2012)

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

wandering third instar larval stage

type III bouton

(Loveall and Deitcher, 2010)

embryonic/larval neuromuscular junction

• type III terminal bouton

(Loveall and Deitcher, 2010)

prepupal stage P2

corpus cardiacum

(Honegger et al., 2002)

pharate adult stage P8 -- pharate adult stage P15(ii)

neuron | subset of larval ventral nerve cord

(Lahr et al., 2012)

adult stage

neuron | subset of abdominal neuromere

(Peabody et al., 2008)

neuron | subset of adult gnathal ganglion

(Peabody et al., 2008)

peptidergic neuron | subset of adult ventral nerve cord

Comment: 0-18h after eclosion

(Lee et al., 2013)

enteroendocrine cell of posterior adult midgut epithelium

Comment: 50% of enteroendocrine cells in midgut

(Scopelliti et al., 2014)

Additional Descriptive Data

Burs-protein is expressed in a subset of peptidergic neurons in the larval ventral nerve cord. Directly after eclosion expression is detected in around 14 neurons in the posterior part of the thoracico-abdominal ganglion. This number decreases to zero over the first day after eclosion.

(Lee et al., 2013)

burs protein is detected in several pairs of neurons in the pharate pupae ventral nerve cord. Strong expression is detected in one neuron in each T3, A5-A7 segments and 2 neurons in segments A1 to A4. All of these neurons also express CCAP transcript, and one neuron in each A1-A4 segments co-expresses pburs transcript. Expression of burs protein is very similar to the expression of burs transcript.

(Lahr et al., 2012)

burs protein is expressed in a subset of CCAP neurons labeled with Scer\GAL4^CCAP.PP in the adult brain, including neurons in the subesophageal ganglion that extend their axons along the midline to the anterior brain.

(Ma et al., 2012)

In the larval ventral nerve cord, burs is prominently expressed in: two prominent pairs of neurons in the subesophageal ganglion; one pair of neurons in each of the first two thoracic neuromeres and two pairs in the third; two pairs of neurons in each of the first four abdominal neuromeres, and one to two pairs in the remaining abdominal neuromeres. In the adult, burs is expressed in a bilateral pair of neurons in the subesophageal ganglion, and in seven bilaterally paired neurons of the third thoracic neuromere and the abdominal ganglion.

(Peabody et al., 2008)

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of bursicon neuropeptide hormone complex

inferred from direct assay

(Mendive et al., 2005)

inferred from physical interaction with FLYBASE:Pburs; FB:FBgn0264810

(Luo et al., 2005)

located_in extracellular region

inferred from direct assay

(assigned by UniProt )

(Dewey et al., 2004)

located_in terminal bouton

inferred from direct assay

(Loveall and Deitcher, 2010)

Expression Deduced from Reporters

Reporter: P{Burs-GAL4.L}

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

peptidergic neuron | subset of larval ventral nerve cord

(Lee et al., 2013)

adult stage

peptidergic neuron | subset of adult ventral nerve cord

Comment: 0-18h after eclosion

(Lee et al., 2013)

Reporter: P{Burs-GAL4.P}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

neuron | subset of abdominal neuromere

(Peabody et al., 2008)

neuron | subset of adult gnathal ganglion

(Peabody et al., 2008)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Burs in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Burs

View exonic expression by tissue for Dmel\Burs

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42560/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0038901

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0038901

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0038901

Flygut - An atlas of the Drosophila adult midgut

FBgn0038901

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 6 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Burs

Transgenic constructs containing regulatory region of Burs

Aberrations (Deficiencies and Duplications) ( 6 )

Inferred from experimentation ( 6 )

Gene disrupted in

Df(3R)e-BS2

(Dewey et al., 2004)

Df(3R)e-GC3

(Dewey et al., 2004)

Df(3R)e-H4

(Dewey et al., 2004, Kiger, 2004.3.4)

Df(3R)Exel6187

(Ryder, 2004.4.26)

Gene not disrupted in

Df(3R)93F^x2

(Dewey et al., 2004)

Df(3R)e-F1

(Dewey et al., 2004)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die before end of P-stage, with Scer\GAL4^Act5C.PI

Burs^JF02260

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Burs^GD3951

viable, with Scer\GAL4^Mef2.PR

Burs^GD3951

viable, with Scer\GAL4^pnr-MD237

Burs^GD3951

Other Phenotypes

Allele

abnormal cell migration | adult stage | female

Burs^Z5569

abnormal cell migration | adult stage | female, with Scer\GAL4^slbo.2.6, Scer\GAL4^upd1.PU

Burs^JF02260

abnormal locomotor rhythm | adult stage, with Scer\GAL4^elav-C155

Burs^JF02260

abnormal mating behavior | mated female, with Scer\GAL4^nSyb.PU

Burs^GD3951

decreased cell number | adult stage, with Scer\GAL4^pros-V1

Burs^UAS.cDa

decreased occurrence of cell division | adult stage, with Scer\GAL4^pros-V1

Burs^UAS.cDa

increased cell number | adult stage, with Scer\GAL4^pros-V1

Burs^KK111063

increased cell number | adult stage | dominant

Burs^Z5569

increased occurrence of cell division | adult stage

increased occurrence of cell division | adult stage, with Scer\GAL4^pros-V1

Burs^KK111063

some die during pharate adult stage, with Scer\GAL4^Act5C.PI

Burs^JF02260

visible, with Scer\GAL4^Act5C.PI

Burs^GD3951

visible, with Scer\GAL4^Burs.PP

Burs^KK111063

visible, with Scer\GAL4^Toll-6-D42

Burs^GD3951

visible (with Burs^Z1091)

Burs^Z5569

visible (with Burs^Z5569)

Burs^Z1091

visible | recessive

Phenotype manifest in

Allele

adult abdomen

adult abdomen (with Burs^Z1091)

Burs^Z5569

adult abdomen (with Burs^Z5569)

Burs^Z1091

adult cuticle

adult cuticle (with Burs^Z1091)

Burs^Z5569

adult cuticle (with Burs^Z5569)

Burs^Z1091

adult midgut

adult midgut, with Scer\GAL4^pros-V1

Burs^KK111063

adult thorax

Burs^Z1091

border follicle cell

Burs^Z5569

border follicle cell, with Scer\GAL4^slbo.2.6, Scer\GAL4^upd1.PU

Burs^JF02260

intestinal stem cell | adult stage

intestinal stem cell | adult stage, with Scer\GAL4^pros-V1

posterior scutellar bristle

Burs^Z1091

posterior scutellar bristle (with Burs^Z1091)

Burs^Z5569

posterior scutellar bristle (with Burs^Z5569)

Burs^Z1091

wing

wing, with Scer\GAL4^Act5C.PI

Burs^GD3951

wing, with Scer\GAL4^Burs.PP

Burs^KK111063

wing, with Scer\GAL4^Toll-6-D42

Burs^GD3951

wing (with Burs^Z1091)

Burs^Z5569

wing (with Burs^Z5569)

Burs^Z1091

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (20)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\BMPER

1 of 15

Yes

Hsap\COCH

1 of 15

Yes

Hsap\CRIM1

1 of 15

Yes

Hsap\FCGBP

1 of 15

Yes

Hsap\FRAS1

1 of 15

Yes

Hsap\KCP

1 of 15

Yes

Hsap\MICOS10

1 of 15

Yes

Hsap\MUC5AC

1 of 15

Yes

Hsap\MUC5B

1 of 15

Yes

Hsap\MUC6

1 of 15

Yes

Hsap\NBL1

1 of 15

Yes

Hsap\NDP

1 of 15

Yes

Hsap\NEFM

1 of 15

Yes

Hsap\OTOG

1 of 15

Yes

Hsap\OTOGL

1 of 15

Yes

Hsap\TECTA

1 of 15

Yes

Hsap\VIT

1 of 15

Yes

Hsap\VWCE

1 of 15

Yes

Hsap\VWF

1 of 15

Yes

Hsap\ZAN

1 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (19)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Muc5b

2 of 15

Yes

Mmus\9530053A07Rik

1 of 15

Mmus\Bmper

1 of 15

Mmus\Coch

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Mmus\Nefm

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Mmus\Vwce

1 of 15

Mmus\Vwf

1 of 15

Mmus\Zan

1 of 15

Rattus norvegicus (Norway rat) (17)

Rnor\Bmper

1 of 13

Yes

Rnor\Coch

1 of 13

Yes

Rnor\Crim1

1 of 13

Yes

Rnor\Fcgbpl1

1 of 13

Yes

Rnor\Fcgbp

1 of 13

Yes

Rnor\Fras1

1 of 13

Yes

Rnor\Kcp

1 of 13

Yes

Rnor\LOC100909913

1 of 13

Yes

Rnor\Muc5b

1 of 13

Yes

Rnor\Nbl1

1 of 13

Yes

Rnor\Ndp

1 of 13

Yes

Rnor\Otogl

1 of 13

Yes

Rnor\Otog

1 of 13

Yes

Rnor\Sspo

1 of 13

Yes

Rnor\Tecta

1 of 13

Yes

Rnor\Vit

1 of 13

Yes

Rnor\Vwf

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (16)

Xtro\bmper

1 of 12

Yes

Xtro\coch

1 of 12

Yes

Xtro\crim1

1 of 12

Yes

Xtro\fras1

1 of 12

Yes

Xtro\kcp

1 of 12

Yes

Xtro\LOC100485197

1 of 12

Yes

Xtro\LOC100492852

1 of 12

Yes

Xtro\LOC100497909

1 of 12

Yes

Xtro\muc6

1 of 12

Yes

Xtro\nbl1

1 of 12

Yes

Xtro\nefm

1 of 12

Yes

Xtro\otogl

1 of 12

Yes

Xtro\tecta.1

1 of 12

Yes

Xtro\vit

1 of 12

Yes

Xtro\vwf

1 of 12

Yes

Xtro\zan

1 of 12

Yes

Danio rerio (Zebrafish) (17)

Drer\bmper

1 of 15

Yes

Drer\crim1

1 of 15

Yes

Drer\fras1

1 of 15

Yes

Drer\LOC100147849

1 of 15

Yes

Drer\muc5.1

1 of 15

Yes

Drer\muc5.2

1 of 15

Yes

Drer\muc5f

1 of 15

Yes

Drer\nbl1

1 of 15

Yes

Drer\ndp

1 of 15

Yes

Drer\otogl

1 of 15

Yes

Drer\scospondin

1 of 15

Yes

Drer\si:ch211-39f2.3

1 of 15

Yes

Drer\si:ch1073-291c23.1

1 of 15

Yes

Drer\si:dkey-65b12.6

1 of 15

Yes

Drer\si:dkey-266m15.6

1 of 15

Yes

Drer\tecta

1 of 15

Yes

Drer\vwf

1 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (20)

Cele\B0507.1

1 of 15

Yes

Cele\C12D12.1

1 of 15

Yes

Cele\C16E9.1

1 of 15

Yes

Cele\C18H7.1

1 of 15

Yes

Cele\clec-199

1 of 15

Yes

Cele\crm-1

1 of 15

Yes

Cele\cutl-23

1 of 15

Yes

Cele\dct-17

1 of 15

Yes

Cele\dur-1

1 of 15

Yes

Cele\F19C6.3

1 of 15

Yes

Cele\F25E2.2

1 of 15

Yes

Cele\F32D8.3

1 of 15

Yes

Cele\F55D12.5

1 of 15

Yes

Cele\H13N06.2

1 of 15

Yes

Cele\irg-5

1 of 15

Yes

Cele\pals-39

1 of 15

Yes

Cele\R11G1.1

1 of 15

Yes

Cele\T01D3.6

1 of 15

Yes

Cele\T09D3.3

1 of 15

Yes

Cele\Y8A9A.2

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\CSS1

1 of 15

Yes

Scer\HPF1

1 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190GEJ )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA12271

Drosophila persimilis

Dper\GL23793

Drosophila willistoni

Dwil\GK12896

Drosophila virilis

Dvir\GJ23072

Drosophila mojavensis

Dmoj\GI24294

Drosophila grimshawi

Dgri\GH18623

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150GVO )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17016419

Glossina morsitans

Tsetse fly

Gmor\GMOY011521

Mayetiola destructor

Hessian fly

Mdes\Mdes011000

Anopheles gambiae

Malaria mosquito

Agam\burs3

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ009600

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0LM2 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\pburs

Danaus plexippus

Monarch butterfly

Dple\DPOGS203171-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS203172-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL005791

Heliconius melpomene

Postman butterfly

Hmel\HMEL005789

Apis florea

Little honeybee

Aflo\2922430436

Apis florea

Little honeybee

Aflo\2147561635

Apis mellifera

Western honey bee

Amel\burs

Apis mellifera

Western honey bee

Amel\GB45445

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP18661

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP18662

Bombus terrestris

Buff-tailed bumblebee

Bter\15203033

Linepithema humile

Argentine ant

Lhum\LH12242

Linepithema humile

Argentine ant

Lhum\LH12247

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:0030af

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:0030b0

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG037268

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG023182

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_03610

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_03609

Tribolium castaneum

Red flour beetle

Tcas\pburs

Tribolium castaneum

Red flour beetle

Tcas\burs

Pediculus humanus

Human body louse

Phum\PHUM498600

Pediculus humanus

Human body louse

Phum\PHUM498610

Rhodnius prolixus

Kissing bug

Rpro\RPRC000797

Cimex lectularius

Bed bug

Clec\CLEC011727

Cimex lectularius

Bed bug

Clec\CLEC011726

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI005281

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI007165

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_13408

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_13409

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0LTT )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR014102

Strigamia maritima

European centipede

Smar\SMAR013675

Ixodes scapularis

Black-legged tick

Isca\ISCW004618

Ixodes scapularis

Black-legged tick

Isca\ISCW004617

Stegodyphus mimosarum

African social velvet spider

Smim\KFM75850.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM75851.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur08g03250

Tetranychus urticae

Two-spotted spider mite

Turt\tetur28g01650

Tetranychus urticae

Two-spotted spider mite

Turt\tetur02g05570

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_312013

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_43247

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0ZCB )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Bursiconb

Strongylocentrotus purpuratus

Purple sea urchin

Spur\burs-alpha-like

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (9)

Gene Symbol

Score

Source

Alignment

1 of 10

1 of 10

Cpn

1 of 10

cv-2

1 of 10

Hml

1 of 10

Muc14A

1 of 10

Rcd2

1 of 10

shot

1 of 10

sls

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Burs

comigration in non denaturing gel electrophoresis, western blot, confirmation by molecular weight

(An et al., 2012)

Burs - Pburs

molecular sieving, molecular weight estimation by staining, comigration in non denaturing gel electrophoresis, western blot, confirmation by molecular weight

(An et al., 2012, Mendive et al., 2005)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Burs

suppressible

Egfr

(Scopelliti et al., 2014)

Burs

suppressible

(Scopelliti et al., 2014)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Subunit Structure (UniProtKB)

Heterodimer of Burs and Pburs.

(UniProt, Q9VD83 )

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0038901

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-73

Cytogenetic map

93F9-93F9

Sequence location

3R:21,769,518..21,770,279 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

93F9-93F9

Limits computationally determined from genome sequence between P{PZ}InR⁰⁵⁵⁴⁵ and P{PZ}tsl⁰⁰⁶¹⁷

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-73

(FlyBase, 2016)

3-74.8

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (8)

Bloomington

40972

w^*; P{Burs-GAL4.P}P12

26719

y¹ v¹; P{TRiP.JF02260}attP2

80811

y¹, v¹; P{TKO.GS04615}attP40

66431

w^*; P{arm-GFP.P}57; Burs^Z5569/TM6B, Tb¹

66432

w^*; P{arm-GFP.P}57; Burs^Z4410/TM6B, Tb⁺

83851

y¹ sc^* v¹ sev²¹; P{SAM.dCas9.GS05285}attP40

VDRC

v102204

P{KK111063}VIE-260B

v13520

w¹¹¹⁸; P{GD3951}v13520

Genomic Clones (17)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (2)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0038901

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0038901

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

42560

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Luan et al., 2006, Luo et al., 2005, Dewey et al., 2004, Honegger et al., 2002)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: bursicon CG13419

(McNabb et al., 2004)

Source for identity of: Burs burs

(FlyBase, 2009-)

Source for database merge of

Source for merge of: burs frl

(Kiger, 2004.3.17)

Additional comments

Other Comments

The rk receptor and its signal Burs appear to be involved in intercellular communication within the border follicle cell cluster itself during border cell migration, as the Burs signal is only required in the border cells.

(Anllo and Schüpbach, 2016)

Bioactive D.melanogaster bursicon is a heterodimer composed of the burs and pburs polypeptides. burs protein by itself does not have bursicon bioactivity.

(Mendive et al., 2005)

Mutants block delamination, migration and bonding of cuticle layers during wing maturation.

(Kiger et al., 2004)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 28 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

42560

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VD83

Other crossreferences

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0038901

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42560/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0038901

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Burs_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0038901

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0038901

Flygut - An atlas of the Drosophila adult midgut

FBgn0038901

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

42560

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC013832

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG13419

MARRVEL_MODEL - MARRVEL (model organism gene)

42560

modMine - A data warehouse for the modENCODE project

FBgn0038901

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0038901

DRSC - Results frm RNAi screens

FBgn0038901

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0038901

FlyMine - An integrated database for Drosophila genomics

FBgn0038901

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

Synonyms and Secondary IDs (22)

Reported As

Symbol Synonym

BURS

(Loveall and Deitcher, 2010, Nässel and Winther, 2010, Davis et al., 2007)

Bur α

(Harwood et al., 2013)

Burs

(Lee et al., 2021, Hadjieconomou et al., 2020, Hung et al., 2020, Statzer and Ewald, 2020, Zhou et al., 2020, Simon et al., 2019, Zhang and Zhou, 2019, Donlea et al., 2018, Liu and Jin, 2017, Transgenic RNAi Project members, 2017-, Chen et al., 2016, Jiang et al., 2016, Lee et al., 2015, Hwang et al., 2014, Asahina and Anderson, 2013.9.23)

Burs α

(Nässel and Zandawala, 2020, Nässel and Winther, 2010)

Burs-α

(Harwood et al., 2014)

BursA

(Koyama et al., 2020)

Bursicon α

(Ben-Menahem, 2021)

Bursα

(Yoshinari et al., 2021, Veverytsa and Allan, 2011, McNabb and Truman, 2006)

CG13419

(Asahina and Anderson, 2013.9.23, Colca et al., 2013, Lemaitre and Miguel-Aliaga, 2013, Keleman et al., 2009.8.5, Perkins et al., 2009.3.31, An et al., 2008, Natzle et al., 2008, Luan et al., 2006, McNabb and Truman, 2006, Mendive et al., 2005, Davis, 2003, Davis, 2001.10.11)

burs

(Garaulet et al., 2021, Scopelliti et al., 2016, Scopelliti et al., 2014, Lee et al., 2013, Lemaitre and Miguel-Aliaga, 2013, Marianes and Spradling, 2013, Japanese National Institute of Genetics, 2012.5.21, Lahr et al., 2012, Gatto and Broadie, 2011, Nässel and Winther, 2010, Hari et al., 2008, Natzle et al., 2008, Peabody et al., 2008, Davis et al., 2007, Peabody et al., 2007, Bowser and Tobe, 2006, Luo et al., 2005)

burs alpha

(Anllo and Schüpbach, 2016)

burs α

(An et al., 2012, Hari et al., 2008)

burs-alpha

(VandenBroeck, 2004.11.9)

bursα

(Colombani and Andersen, 2020, Scopelliti et al., 2019, Luan et al., 2006, Mendive et al., 2005)

frl

Name Synonyms

Bursicon

(Luan et al., 2020, Masuzzo et al., 2019, Nässel, 2018, Steyaert et al., 2018, Asahina et al., 2014, Hwang et al., 2014, Asahina and Anderson, 2013.9.23, Caers et al., 2012, Gatto and Broadie, 2011, Nässel and Winther, 2010, Veenstra et al., 2008)

Bursicon α

(Kim et al., 2021, Ahmad et al., 2020, Zhao and Karpac, 2020)

Bursicon α subunit

(Nässel and Winther, 2010)

bursicon

(Borbolis et al., 2020, Bilousov et al., 2013, Lee et al., 2013, Gatto and Broadie, 2011, Loveall and Deitcher, 2010, Natzle et al., 2008, Peabody et al., 2008, Zhao et al., 2008, Davis et al., 2007, Davis et al., 2007, Kim et al., 2006, Luan et al., 2006, Honegger et al., 2002)

bursicon α

(An et al., 2012, Ma et al., 2012, Gatto and Broadie, 2011, An et al., 2008, Zhao et al., 2008, Mendive et al., 2005)

bursicon α subunit

(Gatto and Broadie, 2011)

bursicon α-subunit

(Chen et al., 2014, Luan et al., 2006)

furled wing

(Kiger, 2004.3.4)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (116)

Report Sections

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