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Gene Dmel\CG6690

General Information
Symbol	Dmel\CG6690	Species	D. melanogaster
Name		Annotation symbol	CG6690
Feature type	protein_coding_gene	FlyBase ID	FBgn0038918
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	93F14-93F14	Sequence location	3R:17,737,538..17,739,313 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG6690 (FBgn0038918). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: flavin-linked sulfhydryl oxidase activity. There is experimental evidence that it is involved in the biological process: multicellular organism reproduction. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: ERV/ALR sulphydryl oxidase; Erv1/Alr; Thioredoxin domain; Thioredoxin-like fold. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of no expression detected. Peak expression observed in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult male accessory gland. Comments on Affy2 ProbeSet: ProbeSet 1631800_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG6690. Gene sequence location is 3R:17737538..17739313.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	References Chen et al., 2010, Science 330(6011): Sequence features BKN26920 HFA16096
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 93F14-93F14   Limits computationally determined from genome sequence between P{PZ}tsl00617 and P{lacW}howj5B5&P{EP}EP738
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG6690 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG6690-RA FBtr0084149  NM_142740   1776   562
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG6690-PA   FBpp0083547   64.8   562   8.23     NP_650997   AAF55938
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Erv1/Alr (IPR006863) Thioredoxin-like fold (IPR012336) Thioredoxin domain (IPR013766) ERV/ALR sulphydryl oxidase (IPR017905)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF55938   BE976471   BT022765   BT022773   BT022797   EL873662
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VD62
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. [an error occurred while processing this directive] modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0038918 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6690-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG6690GD6218 Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of CG6690 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG6690 Class Mutagen Stocks Known lesion CG6690GD6218 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG6690JF03000 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG6690KK106920 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6188 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD6218} NA P{KK106920} NA P{TRiP.JF03000} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
multicellular organism reproduction inferred from expression pattern (Findlay et al., 2009)
Cellular Component
CV term Evidence References
extracellular space inferred from direct assay (Findlay et al., 2009)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
flavin-linked sulfhydryl oxidase activity inferred from sequence or structural similarity (Thorpe, 2002.11.6) thiol oxidase activity inferred from electronic annotation with InterPro:IPR006863, InterPro:IPR017905 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
cell redox homeostasis inferred from electronic annotation with InterPro:IPR013766 (FlyBase Curators et al., 2004-) oxidation-reduction process inferred from electronic annotation with InterPro:IPR006863, InterPro:IPR017905 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG6690 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0038918 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42582
Orthologs
Genome-wide drosophilid orthologs	Dere\GG11095 Dsec\GM26387 Dsim\GD20910 Dyak\GE10255
Curated drosophilid orthologs	Dpse\GA19784   Dsim\GD20910 (Swanson et al., 2001, Findlay et al., 2009)
Linkouts	OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0228128 FBgn0261147 FBgn0181240 FBgn0103397
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	28364 y1 v1; P{TRiP.JF03000}attP2/TM3, Sb1
VDRC	v101104 P{KK106920}VIE-260B v14439 w1118; P{GD6218}v14439
Genomic Clones ( 1 )
	BACR08K01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 5 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP13649 IP13849 IP13949
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	bs50h12 IP13749
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0038918 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42582
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_142740 RefSeq (Proteins) • NP_650997 DDBJ / EMBL / GenBank • AAF55938 Entrez Gene - A searchable database of RefSeq genes. • 42582 UniProtKB/TrEMBL • Q9VD62
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Erv1/Alr (IPR006863) Thioredoxin-like fold (IPR012336) Thioredoxin domain (IPR013766) ERV/ALR sulphydryl oxidase (IPR017905)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0038918 DRSC - Results from RNAi screens. • FBgn0038918 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0038918 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6690-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0038918 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42582 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42582 modMine - Data generated by the modENCODE project. • FBgn0038918 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0228128 FBgn0261147 FBgn0181240 FBgn0103397
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG6690 (Findlay et al., 2009, Keleman et al., 2009.8.5, Perkins et al., 2009, Chen et al., 2010)
Name Synonym
Secondary FlyBase IDs
References ( 17 )
Research paper	Dottorini et al., 2011, BMC Bioinformatics 12: 34 Gepoclu: a software tool for identifying and analyzing gene positional clusters in large-scale gene expression analysis. [FBrf0214379] Mueller et al., 2005, Genetics 171(1): 131--143 Cross-species comparison of Drosophila male accessory gland protein genes. [FBrf0187652] Herold et al., 2003, EMBO J. 22(10): 2472--2483 Genome-wide analysis of nuclear mRNA export pathways in Drosophila. [FBrf0158900]
Supplementary material	Chen et al., 2010, Science 330(6011): Supporting Online Material. [FBrf0216693] Findlay et al., 2009, Genome Res. 19(5): Supplemental Material. [FBrf0208111] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Findlay et al., 2008, PLoS Biol. 6(7): Table S2. High-Confidence Transferred Sfps Detected in Canton S and tudor Experiments. [FBrf0208306] Swanson et al., 2001, Proc. Natl. Acad. Sci. USA 98: Gene characteristics and dN/dS ratios of Drosophila simulans. [FBrf0137427]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Perkins et al., 2009, Update to TRiP stock collection. Update to TRiP stock collection. [FBrf0208864] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335] Thorpe, 2002.11.6, ECM Disulfide formation: sulfhydryl oxidases. ECM Disulfide formation: sulfhydryl oxidases. [FBrf0151621]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]
Curated genome annotation	Li, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126682]