FB2025_02 , released April 17, 2025
Gene: Dmel\Sar1
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General Information
Symbol
Dmel\Sar1
Species
D. melanogaster
Name
Secretion-associated Ras-related 1
Annotation Symbol
CG7073
Feature Type
protein_coding_gene
FlyBase ID
FBgn0038947
Gene Model Status
Current
Stock Availability
14 publicly available
Gene Summary
Secretion-associated Ras-related 1 (Sar1) encodes a small GTPase that is recruited to the endoplasmic reticulum and initiates the recruitment of the COPII subunit complex Sec23/Sec24. [Date last reviewed: 2018-11-08] (FlyBase Gene Snapshot)
All Summaries
Also Known As

l(3)05712, bro5

Key Links
Genomic Location
Cytogenetic map
94A5-94A6
Sequence location
Recombination map
3-74
RefSeq locus
NT_033777 REGION:22356685..22360711
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (21 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables scaffold protein binding
inferred from physical interaction with FLYBASE:Sec16; FB:FBgn0052654
(Ivan et al., 2008)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables GTP binding
inferred from electronic annotation with InterPro:IPR006687, InterPro:IPR006689
(InterPro Project Members, 2004-)
inferred from electronic annotation with InterPro:IPR005225, InterPro:IPR006687, InterPro:IPR006689
(InterPro Project Members, 2004-)
enables GTPase activity
inferred from sequence or structural similarity with SGD:S000006139
(Gene Ontology Curators, 2002-)
inferred from biological aspect of ancestor with PANTHER:PTN000195056
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR006689
(InterPro Project Members, 2004-)
Biological Process (15 terms)
Terms Based on Experimental Evidence (11 terms)
CV Term
Evidence
References
acts_upstream_of_positive_effect chitin-based cuticle development
inferred from mutant phenotype
(Norum et al., 2010)
involved_in chitin-based larval cuticle pattern formation
inferred from mutant phenotype
(Abrams and Andrew, 2005)
involved_in COPII vesicle coating
inferred from mutant phenotype
(Ivan et al., 2008)
involved_in embryonic heart tube development
inferred from mutant phenotype
(Yi et al., 2006)
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport
inferred from mutant phenotype
(Norum et al., 2010)
involved_in host-mediated suppression of symbiont invasion
inferred from high throughput mutant phenotype
(Hodgson et al., 2019)
involved_in larval chitin-based cuticle development
inferred from mutant phenotype
(Abrams and Andrew, 2005)
involved_in mitochondrial membrane organization
inferred from mutant phenotype
(Maddison et al., 2023)
involved_in positive regulation of dendrite morphogenesis
inferred from mutant phenotype
(Ye et al., 2007)
involved_in positive regulation of synapse pruning
inferred from mutant phenotype
(Wang et al., 2018)
involved_in protein localization to plasma membrane
inferred from mutant phenotype
(Kumichel et al., 2015)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport
inferred from biological aspect of ancestor with PANTHER:PTN000195056
(GO Reference Genome Project, 2011-)
involved_in intracellular protein transport
inferred from electronic annotation with InterPro:IPR006687
(InterPro Project Members, 2004-)
involved_in membrane organization
inferred from biological aspect of ancestor with PANTHER:PTN000195056
(GO Reference Genome Project, 2011-)
involved_in regulation of COPII vesicle coating
inferred from biological aspect of ancestor with PANTHER:PTN000195056
(GO Reference Genome Project, 2011-)
inferred from sequence or structural similarity with SGD:S000006139
(Gene Ontology Curators, 2002-)
involved_in vesicle organization
inferred from biological aspect of ancestor with PANTHER:PTN000195056
(GO Reference Genome Project, 2011-)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in endoplasmic reticulum exit site
inferred from direct assay
(Ivan et al., 2008)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
part_of COPII vesicle coat
inferred from sequence or structural similarity with SGD:S000006139
(Gene Ontology Curators, 2002-)
inferred from biological aspect of ancestor with PANTHER:PTN000195056
(GO Reference Genome Project, 2011-)
is_active_in endoplasmic reticulum exit site
inferred from biological aspect of ancestor with PANTHER:PTN000195056
(GO Reference Genome Project, 2011-)
located_in mitochondria-associated endoplasmic reticulum membrane contact site
inferred from sequence or structural similarity with UniProtKB:P20606
(Gene Ontology Curators, 2002-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
GTPase activity
RHEA 19669:
Summaries
Gene Snapshot
Secretion-associated Ras-related 1 (Sar1) encodes a small GTPase that is recruited to the endoplasmic reticulum and initiates the recruitment of the COPII subunit complex Sec23/Sec24. [Date last reviewed: 2018-11-08]
Gene Group (FlyBase)
COAT PROTEIN COMPLEX II -
The Coat Protein Complex II (COPII) mediates protein transport from the ER to Golgi (anterograde transport). COPII recruitment is initiated by the activation of the small GTPase Sar1. Sar1 recruits a heterodimeric complex comprising of Sec23/24, which interacts with cargo and the outer cage - a heterotetramer composed of Sec13/31. (Adapted from PMID:18060556).
ARF GTPASES -
The ADP-Ribosylation Factor (Arf) family are members of the Ras superfamily of small GTPases. Arfs are involved in the regulation of vesicular trafficking mediating processes such as cargo-sorting, vesicle assembly and membrane fusion. (Adapted from PMID:15731001).
Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Sar1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VD29)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.49

Gene model reviewed during 5.46

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.43

Gene model reviewed during 5.55

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Sar1-RA
FBtr0084206
NM_170000
1503
193
Sar1-RC
FBtr0084209
NM_170001
1801
193
Sar1-RD
FBtr0084208
NM_170002
1552
193
Sar1-RE
FBtr0084210
NM_206542
1452
193
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Sar1-PA
FBpp0083604
21.8
193
6.95
Q9VD29
NP_732717
AAF55974
Sar1-PC
FBpp0083607
21.8
193
6.95
Q9VD29
NP_732718
AAN14369
Sar1-PD
FBpp0083606
21.8
193
6.95
Q9VD29
NP_732719
AAN14370
Sar1-PE
FBpp0089284
21.8
193
6.95
Q9VD29
NP_996265
AAS65194
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

193 aa isoforms: Sar1-PA, Sar1-PC, Sar1-PD, Sar1-PE
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Sar1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.65

Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in endoplasmic reticulum exit site
inferred from direct assay
(Ivan et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Sar1 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 11 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Sar1
Transgenic constructs containing regulatory region of Sar1
Aberrations (Deficiencies and Duplications) ( 8 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal, with Scer\GAL4pnr-MD237
lethal (with Df(3R)BSC511)
lethal (with Df(3R)ED6085)
lethal | recessive
lethal - all die before end of larval stage, with Scer\GAL4Mef2.PR
lethal - all die during larval stage, with Scer\GAL4Mef2.PR
partially lethal, with Scer\GAL4tin.CΔ4
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
Sterility
Allele
female sterile | germline clone | recessive
Other Phenotypes
Allele
abnormal cytokinesis | spermatogenesis, with Scer\GAL4VP16.bam
abnormal meiotic cell cycle | spermatogenesis, with Scer\GAL4VP16.bam
abnormal neuroanatomy
abnormal neuroanatomy | cell autonomous | somatic clone
abnormal neuroanatomy | prepupal stage P1 | somatic clone
abnormal neuroanatomy | prepupal stage P1 | somatic clone, with Scer\GAL4ppk.PU
abnormal neuroanatomy | pupal stage, with Scer\GAL4GSG2295
abnormal neuroanatomy | pupal stage | somatic clone
abnormal neuroanatomy | pupal stage | somatic clone, with Scer\GAL4ppk.PU
abnormal neurophysiology | larval stage, with Scer\GAL4egr-GAL4
abnormal neurophysiology | larval stage, with Scer\GAL4NP6293
decreased body size | larval stage, with Scer\GAL4Mef2.PR
increased cell number | larval stage, with Scer\GAL4Hand.Δ
increased cell number | larval stage, with Scer\GAL4NP1029
some die during larval stage, with Scer\GAL4Mef2.PR
Phenotype manifest in
Allele
contractile ring | spermatogenesis, with Scer\GAL4VP16.bam
dendrite & dendritic arborising neuron
dendrite & dendritic arborising neuron | somatic clone | cell autonomous
dendrite & dorsal multidendritic neuron ddaC | somatic clone | cell autonomous
dendritic tree | prepupal stage P1 | somatic clone
dendritic tree | prepupal stage P1 | somatic clone, with Scer\GAL4ppk.PU
dendritic tree | pupal stage, with Scer\GAL4GSG2295
dendritic tree | pupal stage | somatic clone
dendritic tree | pupal stage | somatic clone, with Scer\GAL4ppk.PU
dorsal vessel wall cell
embryonic/first instar larval cuticle
embryonic/larval crystal cell | increased number | larval stage, with Scer\GAL4Hand.Δ
embryonic/larval crystal cell | increased number | larval stage, with Scer\GAL4NP1029
embryonic/larval epidermis
embryonic/larval neuromuscular junction | larval stage, with Scer\GAL4egr-GAL4
embryonic/larval neuromuscular junction | larval stage, with Scer\GAL4NP6293
embryonic/larval perineurial glial cell | larval stage, with Scer\GAL4egr-GAL4
embryonic/larval tracheal section
embryonic pericardial cell
endoplasmic reticulum | late embryonic stage
filamentous actin | spermatogenesis, with Scer\GAL4VP16.bam
Golgi apparatus & dendritic arborising neuron | somatic clone | cell autonomous
larval abdominal segment, with Scer\GAL4egr-GAL4
larval dorsal multidendritic neuron ddaC | prepupal stage P1 | somatic clone
larval dorsal multidendritic neuron ddaC | prepupal stage P1 | somatic clone, with Scer\GAL4ppk.PU
larval dorsal multidendritic neuron ddaC | pupal stage, with Scer\GAL4GSG2295
larval dorsal multidendritic neuron ddaC | pupal stage | somatic clone
larval dorsal multidendritic neuron ddaC | pupal stage | somatic clone, with Scer\GAL4ppk.PU
lymph gland posterior signaling center cell | increased number | larval stage, with Scer\GAL4Hand.Δ
lymph gland posterior signaling center cell | increased number | larval stage, with Scer\GAL4NP1029
male germ cell nucleus | increased number, with Scer\GAL4VP16.bam
mitochondrion | adult stage | decreased number | somatic clone
NMJ bouton | increased number | larval stage, with Scer\GAL4egr-GAL4
sarcomere, with Scer\GAL4Mef2.PR
spermatid, with Scer\GAL4VP16.bam
wing nerve | adult stage | somatic clone
Z disc, with Scer\GAL4Mef2.PR
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (26)
Hsap\SAR1B
13 of 14
Yes
Yes
Hsap\SAR1A
12 of 14
No
Yes
Hsap\ARF1
1 of 14
No
No
Hsap\ARF3
1 of 14
No
No
1  
Hsap\ARF4
1 of 14
No
No
Hsap\ARF5
1 of 14
No
No
1  
Hsap\ARF6
1 of 14
No
No
1  
Hsap\ARFRP1
1 of 14
No
No
Hsap\ARL1
1 of 14
No
No
Hsap\ARL2
1 of 14
No
No
Hsap\ARL3
1 of 14
No
No
Hsap\ARL4A
1 of 14
No
No
Hsap\ARL4C
1 of 14
No
No
1  
Hsap\ARL4D
1 of 14
No
No
Hsap\ARL5A
1 of 14
No
No
1  
Hsap\ARL5B
1 of 14
No
No
Hsap\ARL6
1 of 14
No
No
1  
Hsap\ARL8A
1 of 14
No
No
1  
Hsap\ARL8B
1 of 14
No
No
Hsap\ARL11
1 of 14
No
No
Hsap\ARL13A
1 of 14
No
No
Hsap\ARL13B
1 of 14
No
No
Hsap\ARL14
1 of 14
No
No
Hsap\ARL15
1 of 14
No
No
Hsap\SRPRB
1 of 14
No
No
Hsap\TRIM23
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (20)
Rnor\Sar1b
13 of 14
Yes
Yes
Rnor\Sar1a
2 of 14
No
No
Rnor\Arf5
1 of 14
No
No
Rnor\Arf6
1 of 14
No
No
Rnor\Arfrp1
1 of 14
No
No
Rnor\Arl1
1 of 14
No
No
Rnor\Arl2
1 of 14
No
No
Rnor\Arl3
1 of 14
No
No
Rnor\Arl4a
1 of 14
No
No
Rnor\Arl4d
1 of 14
No
No
Rnor\Arl5c
1 of 14
No
No
Rnor\Arl6
1 of 14
No
No
Rnor\Arl8b
1 of 14
No
No
Rnor\Arl11
1 of 14
No
No
Rnor\Arl13a
1 of 14
No
Yes
Rnor\Arl13b
1 of 14
No
No
Rnor\Arl14
1 of 14
No
No
Rnor\Arl15
1 of 14
No
No
Rnor\Srprb
1 of 14
No
No
Rnor\Trim23
1 of 14
No
No
Mus musculus (laboratory mouse) (20)
Mmus\Sar1b
13 of 14
Yes
Yes
Mmus\Sar1a
11 of 14
No
Yes
Mmus\Arf5
1 of 14
No
No
Mmus\Arf6
1 of 14
No
No
Mmus\Arfrp1
1 of 14
No
No
Mmus\Arl1
1 of 14
No
No
Mmus\Arl2
1 of 14
No
No
Mmus\Arl3
1 of 14
No
No
Mmus\Arl4a
1 of 14
No
No
Mmus\Arl4d
1 of 14
No
No
Mmus\Arl5b
1 of 14
No
No
Mmus\Arl6
1 of 14
No
No
Mmus\Arl8b
1 of 14
No
No
Mmus\Arl11
1 of 14
No
No
Mmus\Arl13a
1 of 14
No
No
Mmus\Arl13b
1 of 14
No
No
Mmus\Arl14
1 of 14
No
No
Mmus\Arl15
1 of 14
No
No
Mmus\Srprb
1 of 14
No
No
Mmus\Trim23
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (19)
Xtro\sar1b
11 of 13
Yes
Yes
Xtro\sar1a
10 of 13
No
Yes
Xtro\arf5
1 of 13
No
No
Xtro\arf6
1 of 13
No
No
Xtro\arf11l.2
1 of 13
No
No
Xtro\arl1
1 of 13
No
No
Xtro\arl2
1 of 13
No
No
Xtro\arl4a
1 of 13
No
No
Xtro\arl5a
1 of 13
No
No
Xtro\arl5b
1 of 13
No
No
Xtro\arl5c
1 of 13
No
No
Xtro\arl8a
1 of 13
No
No
Xtro\arl8b
1 of 13
No
No
Xtro\arl10
1 of 13
No
Yes
Xtro\arl11
1 of 13
No
No
Xtro\arl13a
1 of 13
No
Yes
Xtro\arl13b
1 of 13
No
Yes
Xtro\ppp1r14c
1 of 13
No
No
Xtro\srprb
1 of 13
No
No
Danio rerio (Zebrafish) (31)
Drer\sar1b
13 of 14
Yes
Yes
Drer\sar1ab
12 of 14
No
Yes
Drer\arf1
1 of 14
No
No
Drer\arf4a
1 of 14
No
No
Drer\arf4b
1 of 14
No
No
Drer\arf6a
1 of 14
No
No
Drer\arf6b
1 of 14
No
No
Drer\arfrp1
1 of 14
No
No
Drer\arl1
1 of 14
No
No
Drer\arl2
1 of 14
No
No
Drer\arl3a
1 of 14
No
No
Drer\arl3b
1 of 14
No
No
Drer\arl3l1
1 of 14
No
No
Drer\arl3l2
1 of 14
No
No
Drer\arl4ab
1 of 14
No
No
Drer\arl4d
1 of 14
No
No
Drer\arl5c
1 of 14
No
No
Drer\arl6
1 of 14
No
No
Drer\arl8a
1 of 14
No
No
Drer\arl8
1 of 14
No
No
Drer\arl11
1 of 14
No
No
Drer\arl13a
1 of 14
No
No
Drer\arl13b
1 of 14
No
No
Drer\arl14
1 of 14
No
No
Drer\arl15a
1 of 14
No
No
Drer\arl15b
1 of 14
No
No
Drer\sar1aa
1 of 14
No
Yes
Drer\si:ch1073-165f9.2
1 of 14
No
No
Drer\srprb
1 of 14
No
No
Drer\trim23
1 of 14
No
No
Drer\zgc:110286
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (17)
Cele\sar-1
13 of 14
Yes
Yes
Cele\arc-1
1 of 14
No
No
Cele\arf-1
1 of 14
No
No
Cele\arf-5
1 of 14
No
No
Cele\arf-6
1 of 14
No
No
Cele\arl-1
1 of 14
No
No
Cele\arl-3
1 of 14
No
No
Cele\arl-5
1 of 14
No
No
Cele\arl-6
1 of 14
No
No
Cele\arl-8
1 of 14
No
No
Cele\arl-13
1 of 14
No
Yes
Cele\evl-20
1 of 14
No
No
Cele\gpa-18
1 of 14
No
No
Cele\R186.3
1 of 14
No
No
Cele\rab-33
1 of 14
No
No
Cele\warf-1
1 of 14
No
No
Cele\Y54E10BR.2
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (11)
Agam\AgaP_AGAP004098
11 of 12
Yes
Yes
Agam\AgaP_AGAP002931
1 of 12
No
No
Agam\AgaP_AGAP003905
1 of 12
No
No
Agam\AgaP_AGAP004227
1 of 12
No
No
Agam\AgaP_AGAP004496
1 of 12
No
No
Agam\AgaP_AGAP004586
1 of 12
No
No
Agam\AgaP_AGAP006688
1 of 12
No
No
Agam\AgaP_AGAP006890
1 of 12
No
No
Agam\AgaP_AGAP011254
1 of 12
No
No
Agam\AgaP_AGAP011730
1 of 12
No
No
Agam\AgaP_AGAP012014
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (19)
Atha\AT3G62560
13 of 13
Yes
Yes
Atha\SAR2
13 of 13
Yes
Yes
Atha\SAR1B
12 of 13
No
Yes
Atha\SARA1A
12 of 13
No
Yes
Atha\AT1G02620
4 of 13
No
Yes
Atha\ARF1
1 of 13
No
No
Atha\ARFA1D
1 of 13
No
No
Atha\ARFA1E
1 of 13
No
No
Atha\ARFA1F
1 of 13
No
No
Atha\ARFB1A
1 of 13
No
No
Atha\ARFB1B
1 of 13
No
No
Atha\ARFC1
1 of 13
No
No
Atha\ARLA1A
1 of 13
No
No
Atha\ARLA1B
1 of 13
No
No
Atha\ARLA1C
1 of 13
No
No
Atha\ARLA1D
1 of 13
No
No
Atha\AT2G18770
1 of 13
No
No
Atha\AT5G05670
1 of 13
No
No
Atha\TTN5
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (7)
Scer\SAR1
11 of 13
Yes
Yes
Scer\ARF1
1 of 13
No
No
Scer\ARF2
1 of 13
No
No
Scer\ARF3
1 of 13
No
No
Scer\ARL1
1 of 13
No
No
Scer\ARL3
1 of 13
No
No
Scer\SRP102
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (5)
Spom\sar1
11 of 12
Yes
Yes
Spom\alp41
1 of 12
No
No
Spom\arf1
1 of 12
No
No
Spom\arf6
1 of 12
No
No
Spom\srp102
1 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Sar1. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (16)
Arf1
2 of 13
Arf4
2 of 13
Arf6
2 of 13
Arfrp1
2 of 13
Arl1
2 of 13
Arl2
2 of 13
Arl4
2 of 13
Arl5
2 of 13
Arl8
2 of 13
CG17819
2 of 13
dnd
2 of 13
Arl6
1 of 13
CG11356
1 of 13
CG13692
1 of 13
Rab30
1 of 13
SrpRβ
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    SAR1B; secretion associated Ras related GTPase 1B
    13 of 14
    607690
    SAR1A; secretion associated Ras related GTPase 1A
    12 of 14
    607691
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        Summary of Genetic Interactions
        Interaction Browsers
        View in FlyBase Interactions Browser   View in MIST tool (external link)
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Sar1
        suppressible
        bnl
        (Destalminil-Letourneau et al., 2021)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        btl|stumps
        enhanceable
        Sar1
        (Zhu et al., 2005)
        dpy
        enhanceable
        Sar1
        (Kandasamy et al., 2021)
        stumps
        enhanceable
        Sar1
        (Zhu et al., 2005)
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        FlyBase
        External Links
        External Data
        Linkouts
        KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Class of Gene
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        3R
        Recombination map
        3-74
        Cytogenetic map
        94A5-94A6
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        94A5-94A6
        Limits computationally determined from genome sequence between P{lacW}howj5B5&P{EP}EP738 and P{lacW}l(3)L3560L3560
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        94A3-94A4
        (determined by in situ hybridisation)
        (Spradling et al., 1999, BDGP Project Members, 1994-1999)
        Experimentally Determined Recombination Data
        Location

        3-74

        (FlyBase, 2016)

        3-77.0

        (Comeron et al., 2012)

        2-

        (Rabouille, 2000.3.15)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (14)
        Genomic Clones (18)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (402)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        Antibody Information
        Laboratory Generated Antibodies
         
        Commercially Available Antibodies
         
        Cell Line Information
        Publicly Available Cell Lines
         
          Other Stable Cell Lines
           
          Other Comments

          Mutants have reduced dendritic arbors but normal axonal growth in the class IV dendritic arborization (da) neurons.

          (Ye et al., 2007)

          Identification: Enhancer trap expression pattern survey for loci expressed in the ring gland.

          (Harvie et al., 1998)
          Relationship to Other Genes
          Source for database merge of

          Source for merge of: sar1 l(3)05712

          (Levis, 2002.10.8)

          Source for merge of: sar1 anon- EST:Liang-1.48

          (FlyBase, 1996-)
          Additional comments

          Source for identity of sar1 CG7073 was sequence comparison ( date:000327 ).

          (FlyBase, 1996-)

          Source for merge of sar1 anon- EST:Liang-1.48 was sequence comparison ( date:030722 ).

          (FlyBase, 1996-)
          Nomenclature History
          Source for database identify of

          Source for identity of: sar1 CG7073

          (FlyBase, 1996-)

          Source for identity of: Sar1 sar1

          (FlyBase, 2009-)
          Nomenclature comments
          Etymology

          Named "Sar1" after the S. cerevisiae ortholog.

          (FlyBase, 2009-)
          Synonyms and Secondary IDs (20)
          Reported As
          Symbol Synonym
          5712
          (Harvie et al., 1998)
          CG7073
          (Hosono et al., 2015, Schertel et al., 2013, Jaspers et al., 2012, Cammarato et al., 2011, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Sinka et al., 2008, Cermelli et al., 2006, Dorer et al., 2006, Colicelli, 2004, Dunne et al., 2002)
          Dar-3
          (Copf, 2015)
          Dar3
          (Puram and Bonni, 2013)
          Dm Sar1
          (Jekely, 2003)
          NP_732719
          (Jekely, 2003)
          Q95SY7
          (Rojas et al., 2012)
          SAR1
          (Dorer et al., 2006)
          Sar1
          (Maddison et al., 2023, Ugrankar-Banerjee et al., 2023, Xu et al., 2023, Hodgson et al., 2022, Song et al., 2022, Camelo and Luschnig, 2021, Destalminil-Letourneau et al., 2021, Furusawa and Emoto, 2021, Pang et al., 2021, Pitsidianaki et al., 2021, Saito et al., 2021, Yang et al., 2021, Hodgson et al., 2019, Meltzer, 2019-, Meltzer et al., 2019, Zeledon et al., 2019, Gene Disruption Project members, 2018-, Wang et al., 2018, Hsu and Drummond-Barbosa, 2017, Liu et al., 2017, Transgenic RNAi Project members, 2017-, Roman-Fernandez and Bryant, 2016, Copf, 2015, Fox and Andrew, 2015, Kumichel et al., 2015, Chen et al., 2014, Zacharogianni et al., 2014, Drechsler et al., 2013, Iyer et al., 2013, Lerner et al., 2013, Zhang et al., 2013, Aikin et al., 2012, Pastor-Pareja and Xu, 2011, Zacharogianni et al., 2011, D'Ambrosio and Vale, 2010, Snee and Macdonald, 2009, Beller et al., 2008, Ivan et al., 2008, Qin et al., 2008, Sinka et al., 2008, Tsarouhas et al., 2007, Ye et al., 2007, Yi, 2006, Yi et al., 2006, Wilhelm et al., 2005, Jekely, 2003, Pasqualato et al., 2002)
          anon-EST:Liang-1.48
          bro5
          (Yi, 2006, Yi et al., 2006)
          clone 1.48
          (Liang and Biggin, 1998)
          dar3
          (Ye et al., 2007)
          dsar1
          (Dunne et al., 2002)
          l(3)05712
          (Spradling et al., 1999, BDGP Project Members, 1994-1999)
          sar1
          (Luo et al., 2025, Tsarouhas et al., 2023, Gera et al., 2022, Kandasamy et al., 2021, Kanwal et al., 2021, Kumichel et al., 2015, Luck et al., 2014, Neumüller et al., 2013, Schertel et al., 2013, Abruzzi et al., 2011, Lindquist et al., 2011, Pastor-Pareja and Xu, 2011, Langer et al., 2010, Neumann et al., 2010, Norum et al., 2010, Massarwa et al., 2009, Christensen et al., 2008.4.15, Christensen et al., 2008.10.20, Guo et al., 2008, Jayaram et al., 2008, Bakal et al., 2007, Buszczak et al., 2007, Huang et al., 2007, Maines et al., 2007, Tsarouhas et al., 2007, Wilhelm, 2007, Cermelli et al., 2006, Zhu et al., 2005)
          Name Synonyms
          Sar1 ortholog
          Secretion-associated Ras-related 1
          dendritic arbor reduction 3
          (Ye et al., 2007)
          sar1
          (Jaspers et al., 2012, Cammarato et al., 2011, Huang et al., 2007)
          secretion-associated RAS-related 1
          (Kumichel et al., 2015)
          Secondary FlyBase IDs
          • FBgn0010874
          • FBgn0025985
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          Study result (0)
          Result
          Result Type
          Title
          External Crossreferences and Linkouts ( 60 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
          FlyMine - An integrated database for Drosophila genomics
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          MARRVEL_MODEL - MARRVEL (model organism gene)
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          References (148)