A Database of Drosophila Genes & Genomes

FB2008_06, released July 3, 2008
 

Gene Dmel\sar1

General Information
SymbolDmel\sar1SpeciesD. melanogaster
Namesar1Annotation symbolCG7073
Feature typeprotein_coding_geneFlyBase IDFBgn0038947
Created / Updated2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)3RRecombination map2-
Cytogenetic map 94A5-94A6 Sequence location3R:18,182,397..18,186,440 [+]
Map ( GBrowse ) detailed view
hide Summary Information
Automatically generated summary

See sections below for more information
This gene is referred to in FlyBase by the symbol sar1 (CG7073, FBgn0038947). It has the cytological map location 94A5-94A6. Its sequence location is 3R:18182397..18186440. Its molecular function is described as: GTP binding; GTPase activity. It is involved in the biological processes: embryonic heart tube development; larval chitin-based cuticle development; chitin-based larval cuticle pattern formation; negative regulation of dendrite morphogenesis; intracellular protein transport; small GTPase mediated signal transduction. 9 alleles are reported. The phenotypes of these alleles are annotated with: embryonic pericardial cell; cardioblast. It has 5 annotated transcripts and 5 annotated polypeptides.

hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
94A5-94A6  
Limits computationally determined from genome sequence between P{lacW}howj5B5&P{EP}EP738 and P{lacW}l(3)L3560L3560  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
94A3-94A4
(determined by in situ hybridisation)  
(Spradling et al., 1999)
94A3-94A4
(determined by in situ hybridisation)  
(BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
2-
(Rabouille, 2000.3.15)
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology)
References
Gene Order (overall orientation not stated)
References
hide Gene Model & Products
Please see the GBrowse view of Dmel\sar1 for information on other features
detailed view FBtr0084205 FBtr0084210 FBtr0084207 FBtr0084209 FBtr0084206 FBtr0084208 FBtr0084239 FBpp0083603 FBpp0083607 FBpp0089284 FBpp0083606 FBpp0083604 FBpp0083605 FBpp0083632 FBti0011675 FBti0099927 FBti0037029 FBti0009929 FBti0039416 FBti0007851
Comments on Gene Model
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
sar1-RA
FBtr0084206
 NM_170000
  1520
  193
sar1-RB
FBtr0084207
 NM_142768
  3001
  155
sar1-RC
FBtr0084209
 NM_170001
  1818
  193
sar1-RD
FBtr0084208
 NM_170002
  1623
  193
sar1-RE
FBtr0084210
 NM_206542
  1569
  193
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
sar1-PA  
FBpp0083604  
21.8  
193  
6.95  
  NP_732717
  AAF55974
sar1-PB  
FBpp0083605  
17.5  
155  
5.71  
  NP_651025
  AAN14371
sar1-PC  
FBpp0083607  
21.8  
193  
6.95  
  NP_732718
  AAN14369
sar1-PD  
FBpp0083606  
21.8  
193  
6.95  
  NP_732719
  AAN14370
sar1-PE  
FBpp0089284  
21.8  
193  
6.95  
  NP_996265
  AAS65194
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts
PANTHER - Protein classification by function, families, and pathways
•
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
•
Ras GTPase (IPR001806)
Small GTP-binding protein (IPR005225)
GTP-binding protein SAR1 (IPR006687)
ARF/SAR superfamily (IPR006689)
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
AE003738
AAF55974
 
AE003738
AAN14369
 
AE003738
AAN14370
 
AE003738
AAN14371
 
AE003738
AAS65194
 
AI107064
 
AI107801
 
AI124278
 
AI134082
 
AI260873
 
AI295636
 
AI456441
 
AI511647
 
AI514533
 
AI516033
 
AI519617
 
AI530931
 
AJ276483
CAB81550
 
AQ073028
 
AW943461
 
AY060423
AAL25462
 
BE975361
 
BE977174
 
BF497363
 
BG637702
 
BG639018
 
BI168514
 
BI351942
 
BI352117
 
BI356552
 
BI356969
 
BI358116
 
BI366640
 
BI375065
 
BI580167
 
BI604661
 
BI604818
 
BI626528
 
BI632530
 
BI633388
 
BI635928
 
BI636528
 
BI638571
 
BI639098
 
BP546024
 
BP546285
 
BP546431
 
BP548343
 
BP553201
 
BP555816
 
BQ103166
 
BQ103501
 
BT001745
AAN71500
 
CO153141
 
CO154624
 
CO155717
 
CO156114
 
CO156449
 
CO180033
 
CO190238
 
CO191691
 
CO274411
 
CO274711
 
CO279825
 
CO280585
 
CO281690
 
CO282618
 
CO302233
 
CO303291
 
CO307284
 
CO310453
 
CO311972
 
CO314561
 
CO316061
 
CO332812
 
CO335601
 
CO338462
 
CO338780
 
EC064983
 
EC066085
 
EC067554
 
EC069443
 
EC070264
 
EC073345
 
EC073565
 
EC077923
 
EC083232
 
EC087545
 
EC087637
 
EC088342
 
EC089348
 
EC091000
 
EC195252
 
EC198165
 
EC199497
 
EC202438
 
EC204869
 
EC227621
 
EC232835
 
EC234780
 
EC234784
 
EC244005
 
EC244498
 
EC251194
 
EC261791
 
EC262894
 
EC262961
 
EC264406
 
EC266648
 
EC267250
 
EC267464
 
EC267720
 
G01169
 
HL07942
 
LD41767
 
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
    Maps to
    Does NOT map to
    Identified with
    (Dunne et al., 2002)
    (BDGP Project Members, 2000-, Abrams and Andrew, 2005)
    (BDGP Project Members, 2000-)
    (BDGP Project Members, 1994-1999, Spradling et al., 1999)
    hide Mapped Features & Mutations
    Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here
    Type
    Symbol & Location
    Additional Notes
    References
    hide External Data
    Linkouts
    DEDB - Drosophila exon database: splicing graphs
    •
    Crossreferences
    hide Expression Data
    FlyBase-Curated Data
    Transcript and
    Protein data     		Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
    hide Summary of Transcript Expression
    Stage
    Tissue/Position
    Reference
    Marker for
      Subcellular Localization
      CV Term
      hide Summary of Polypeptide Expression
      Stage
      Tissue/Position
      Reference
      Marker for
        Subcellular Localization
        CV Term
        hide Microarray Data
        Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002)
        Untitled Document detailed view FBtr0084205 FBtr0084210 FBtr0084207 FBtr0084209 FBtr0084206 FBtr0084208 FBtr0084239
        AI519617
        hide External Data & Images
        Linkouts
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        •
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        •
        GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
        •
        FlyExpress - Embryonic expression images (BDGP data)
        •
        Show all FlyExpress processed images for sar1
        hide Alleles & Phenotypes
        hide Summary of Allele Phenotypes
        Lethality
        Allele
        lethal
        lethal | recessive
        Other Phenotypes
        Allele
        neuroanatomy defective
        neuroanatomy defective | cell autonomous | somatic clone
        Sterility
        Allele
        female sterile | germ-line clone | recessive
        Phenotype manifest in
        Allele
        embryonic pericardial cell
        cardioblast
        dendrite & dendritic arborising neuron
        dendrite & dendritic arborising neuron | somatic clone | cell autonomous
        dendrite & dorsal multidendritic neuron ddaC | somatic clone | cell autonomous
        Golgi apparatus & dendritic arborising neuron | somatic clone | cell autonomous
        hide Classical Alleles ( 8 )
        For All Classical Alleles Show

        Allele of sar1ClassMutagenStocksKnown lesion
        sar1057121 Yes
        sar1074840 --
        sar111-3-63
          		0 --
          sar1280 Yes
          sar1710 Yes
          sar1CA076740 Yes
          sar1EP35751 --
          sar1unspecified
            		0 --
            hide Alleles Carried on Transgenic Constructs ( 1 )
            For All Alleles Carried on Transgenic Constructs Show

            Allele of sar1ClassMutagenStocksKnown lesion
            sar1GD105932 Yes
            hide Aneuploid Aberrations
            Useful deficiency
             
            Useful duplication
             
            Disrupted in
            (Christensen et al., 2008.4.15)
            (Ryder and Roote, 2004.11.10)
            (Ryder and Roote, 2004.11.10)
            (Ryder, 2004.4.26)
            (Spradling et al., 1999, BDGP Project Members, 1994-1999)
            Not disrupted in
            (Spradling et al., 1999, BDGP Project Members, 1994-1999)
            (Spradling et al., 1999)
            hide Transgenic Constructs & Insertions
            Transgenic Constructs
            Type of construct
            Name
            Expression data
            UAS construct
            P{GD10593}
            NA
            Insertions
            Type of insertions
            Name
            Expression data
            insertion of mobile activating element
            P{EP}sar1EP3575
            NA
            miscellaneous insertions
            P{PTT-GA}sar1CA07674
            NA
            insertion of enhancer trap
            P{PZ}sar105712
            Yes
            P{PZ}sar107484
            No
            hide Related Comments
            Please look at the allele reports for the complete phenotype data
            Mutants have reduced dendritic arbors but normal axonal growth in the class IV dendritic arborization (da) neurons.
            (Ye et al., 2007)
            hide Gene Ontology: Function, Process & Cellular Component ( 10 )
            hide Molecular Function
            CV term
            Evidence
            References
            GTP binding
            inferred from sequence or structural similarity
            (Liang and Biggin, 1998)
            inferred from electronic annotation with InterPro:IPR001806, InterPro:IPR005225, InterPro:IPR006687, InterPro:IPR006689
            (FlyBase Curators et al., 2004-)
            GTPase activity
            inferred from sequence or structural similarity
            (Rabouille, 2000.3.15)
            inferred from sequence or structural similarity
            (Jekely, 2003)
            hide Biological Process
            CV term
            Evidence
            References
            chitin-based larval cuticle pattern formation
            inferred from mutant phenotype
            (Abrams and Andrew, 2005)
            embryonic heart tube development
            inferred from mutant phenotype
            (Yi et al., 2006)
            intracellular protein transport
            inferred from electronic annotation with InterPro:IPR006687
            (FlyBase Curators et al., 2004-)
            larval chitin-based cuticle development
            inferred from mutant phenotype
            (Abrams and Andrew, 2005)
            negative regulation of dendrite morphogenesis
            inferred from mutant phenotype
            (Ye et al., 2007)
            small GTPase mediated signal transduction
            inferred from electronic annotation with InterPro:IPR001806
            (FlyBase Curators et al., 2004-)
            hide Cellular Component
            CV term
            Evidence
            References
            ER to Golgi transport vesicle
            inferred from sequence or structural similarity
            (Rabouille, 2000.3.15)
            lipid particle
            inferred from direct assay
            (Cermelli et al., 2006)
            hide Sequence Ontology: Class of Gene
            protein_coding_gene
             
            nuclear_gene
             
            hide Int