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Gene Dmel\CG5380

General Information
Symbol	Dmel\CG5380	Species	D. melanogaster
Name		Annotation symbol	CG5380
Feature type	protein_coding_gene	FlyBase ID	FBgn0038951
Gene Model Status	Current	Stock availability	2 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	94A6-94A6	Sequence location	3R:18,191,802..18,193,095 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG5380 (FBgn0038951). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: DNA-directed RNA polymerase activity. There is experimental evidence that it is involved in the biological process: neurogenesis. 3 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: RNA polymerase Rpc34; RNA polymerase Rpc34-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1633650_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG5380. Gene sequence location is 3R:18191802..18193095.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 94A6-94A6   Limits computationally determined from genome sequence between P{lacW}l(3)L3560L3560 and P{PZ}l(3)rQ178rQ178
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG5380 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.49
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG5380-RA FBtr0084236  NM_142772   1022   293 CG5380-RB FBtr0305320  NM_001260308   1102   293
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG5380-PA   FBpp0083629   32.6   293   5.61     NP_651029   AAF55978 CG5380-PB   FBpp0293863   32.6   293   5.61     NP_001247237   AFH06555
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • RNA polymerase Rpc34 (IPR007832) RNA polymerase Rpc34-like (IPR016049)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF55978   AE014297 AFH06555   AY119241 AAM51101   BI351752   BI632166   BI637540   BT124831
UniProtKB/Swiss-Prot	Q9VD25
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    68.075 Larval Midgut    47.1 Larval Hindgut    24.4 Larval Malpighian Tubules    34.9 Larval Fat Body    39.8 Larval Salivary Gland    86.9 Larval Trachea    67.475 Larval Carcass    30.825 Adult Head    43.8 Adult Eye    54.15 Adult Brain    69.1 Adult Thoracic-Abdominal Ganglion    74.7 Adult Crop    56.4 Adult Midgut    32.9 Adult Hindgut    34 Adult Malpighian Tubules    34.9 Adult Fat Body    34.7 Adult Salivary Gland    48.4 Adult Heart    34.8 Adult VirginFemale Spermatheca    74.4 Adult InseminatedFemale Spermatheca    73.7 Adult Ovary    77.8 Adult Testis    48.9 Adult Male Accessory Gland    53.2 Adult Carcass    32.3 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    68.075 Larval Midgut    47.1 Larval Hindgut    24.4 Larval Malpighian Tubules    34.9 Larval Fat Body    39.8 Larval Salivary Gland    86.9 Larval Trachea    67.475 Larval Carcass    30.825 Adult Head    43.8 Adult Eye    54.15 Adult Brain    69.1 Adult Thoracic-Abdominal Ganglion    74.7 Adult Crop    56.4 Adult Midgut    32.9 Adult Hindgut    34 Adult Malpighian Tubules    34.9 Adult Fat Body    34.7 Adult Salivary Gland    48.4 Adult Heart    34.8 Adult VirginFemale Spermatheca    74.4 Adult InseminatedFemale Spermatheca    73.7 Adult Ovary    77.8 Adult Testis    48.9 Adult Male Accessory Gland    53.2 Adult Carcass    32.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    68.075 Larval Midgut    47.1 Larval Hindgut    24.4 Larval Malpighian Tubules    34.9 Larval Fat Body    39.8 Larval Salivary Gland    86.9 Larval Trachea    67.475 Larval Carcass    30.825 Adult Head    43.8 Adult Eye    54.15 Adult Brain    69.1 Adult Thoracic-Abdominal Ganglion    74.7 Adult Crop    56.4 Adult Midgut    32.9 Adult Hindgut    34 Adult Malpighian Tubules    34.9 Adult Fat Body    34.7 Adult Salivary Gland    48.4 Adult Heart    34.8 Adult VirginFemale Spermatheca    74.4 Adult InseminatedFemale Spermatheca    73.7 Adult Ovary    77.8 Adult Testis    48.9 Adult Male Accessory Gland    53.2 Adult Carcass    32.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    68.075 Larval Midgut    47.1 Larval Hindgut    24.4 Larval Malpighian Tubules    34.9 Larval Fat Body    39.8 Larval Salivary Gland    86.9 Larval Trachea    67.475 Larval Carcass    30.825 Adult Head    43.8 Adult Eye    54.15 Adult Brain    69.1 Adult Thoracic-Abdominal Ganglion    74.7 Adult Crop    56.4 Adult Midgut    32.9 Adult Hindgut    34 Adult Malpighian Tubules    34.9 Adult Fat Body    34.7 Adult Salivary Gland    48.4 Adult Heart    34.8 Adult VirginFemale Spermatheca    74.4 Adult InseminatedFemale Spermatheca    73.7 Adult Ovary    77.8 Adult Testis    48.9 Adult Male Accessory Gland    53.2 Adult Carcass    32.3 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    68.075 Larval Midgut    47.1 Larval Hindgut    24.4 Larval Malpighian Tubules    34.9 Larval Fat Body    39.8 Larval Salivary Gland    86.9 Larval Trachea    67.475 Larval Carcass    30.825 Adult Head    43.8 Adult Eye    54.15 Adult Brain    69.1 Adult Thoracic-Abdominal Ganglion    74.7 Adult Crop    56.4 Adult Midgut    32.9 Adult Hindgut    34 Adult Malpighian Tubules    34.9 Adult Fat Body    34.7 Adult Salivary Gland    48.4 Adult Heart    34.8 Adult VirginFemale Spermatheca    74.4 Adult InseminatedFemale Spermatheca    73.7 Adult Ovary    77.8 Adult Testis    48.9 Adult Male Accessory Gland    53.2 Adult Carcass    32.3 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    68.075 Larval Midgut    47.1 Larval Hindgut    24.4 Larval Malpighian Tubules    34.9 Larval Fat Body    39.8 Larval Salivary Gland    86.9 Larval Trachea    67.475 Larval Carcass    30.825 Adult Head    43.8 Adult Eye    54.15 Adult Brain    69.1 Adult Thoracic-Abdominal Ganglion    74.7 Adult Crop    56.4 Adult Midgut    32.9 Adult Hindgut    34 Adult Malpighian Tubules    34.9 Adult Fat Body    34.7 Adult Salivary Gland    48.4 Adult Heart    34.8 Adult VirginFemale Spermatheca    74.4 Adult InseminatedFemale Spermatheca    73.7 Adult Ovary    77.8 Adult Testis    48.9 Adult Male Accessory Gland    53.2 Adult Carcass    32.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    68.075 Larval Midgut    47.1 Larval Hindgut    24.4 Larval Malpighian Tubules    34.9 Larval Fat Body    39.8 Larval Salivary Gland    86.9 Larval Trachea    67.475 Larval Carcass    30.825 Adult Head    43.8 Adult Eye    54.15 Adult Brain    69.1 Adult Thoracic-Abdominal Ganglion    74.7 Adult Crop    56.4 Adult Midgut    32.9 Adult Hindgut    34 Adult Malpighian Tubules    34.9 Adult Fat Body    34.7 Adult Salivary Gland    48.4 Adult Heart    34.8 Adult VirginFemale Spermatheca    74.4 Adult InseminatedFemale Spermatheca    73.7 Adult Ovary    77.8 Adult Testis    48.9 Adult Male Accessory Gland    53.2 Adult Carcass    32.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    68.075 Larval Midgut    47.1 Larval Hindgut    24.4 Larval Malpighian Tubules    34.9 Larval Fat Body    39.8 Larval Salivary Gland    86.9 Larval Trachea    67.475 Larval Carcass    30.825 Adult Head    43.8 Adult Eye    54.15 Adult Brain    69.1 Adult Thoracic-Abdominal Ganglion    74.7 Adult Crop    56.4 Adult Midgut    32.9 Adult Hindgut    34 Adult Malpighian Tubules    34.9 Adult Fat Body    34.7 Adult Salivary Gland    48.4 Adult Heart    34.8 Adult VirginFemale Spermatheca    74.4 Adult InseminatedFemale Spermatheca    73.7 Adult Ovary    77.8 Adult Testis    48.9 Adult Male Accessory Gland    53.2 Adult Carcass    32.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    43.8   NA  Eye    54.15   NA  Brain    69.1   68.075  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    74.7   NA  Crop    56.4   47.1  Midgut    no informative data   24.4  Hindgut    34   34.9  Malpighian Tubules    34.9   39.8  Fat Body    34.7   86.9  Salivary Gland    48.4   NA  Heart    34.8   67.475  Trachea    NA   NA  VirginFemale Spermatheca    74.4   NA  InseminatedFemale Spermatheca    73.7   NA  Ovary    77.8   NA  Testis    48.9   NA  Male Accessory Gland    53.2   30.825  Carcass    32.3 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    8 central nervous system, pupae P8    5 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    4 head, mated 20-day female    2 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    8 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    2 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    3 fat body, white prepupae    4 fat body, pupae P8    1 carcass, larvae L3 wandering    6 carcass, 1-day adult    2 carcass, 4-day adult    5 carcass, 20-day adult    3 ovary, virgin 4-day female    15 ovary, mated 4-day female    17 testis, mated 4-day male    13 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    8 central nervous system, pupae P8    5 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    4 head, mated 20-day female    2 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    8 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    2 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    3 fat body, white prepupae    4 fat body, pupae P8    1 carcass, larvae L3 wandering    6 carcass, 1-day adult    2 carcass, 4-day adult    5 carcass, 20-day adult    3 ovary, virgin 4-day female    15 ovary, mated 4-day female    17 testis, mated 4-day male    13 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    8 central nervous system, pupae P8    5 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    4 head, mated 20-day female    2 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    8 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    2 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    3 fat body, white prepupae    4 fat body, pupae P8    1 carcass, larvae L3 wandering    6 carcass, 1-day adult    2 carcass, 4-day adult    5 carcass, 20-day adult    3 ovary, virgin 4-day female    15 ovary, mated 4-day female    17 testis, mated 4-day male    13 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    8 central nervous system, pupae P8    5 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    4 head, mated 20-day female    2 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    8 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    2 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    3 fat body, white prepupae    4 fat body, pupae P8    1 carcass, larvae L3 wandering    6 carcass, 1-day adult    2 carcass, 4-day adult    5 carcass, 20-day adult    3 ovary, virgin 4-day female    15 ovary, mated 4-day female    17 testis, mated 4-day male    13 accessory gland, mated 4-day male    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    8 central nervous system, pupae P8    5 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    4 head, mated 20-day female    2 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    8 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    2 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    3 fat body, white prepupae    4 fat body, pupae P8    1 carcass, larvae L3 wandering    6 carcass, 1-day adult    2 carcass, 4-day adult    5 carcass, 20-day adult    3 ovary, virgin 4-day female    15 ovary, mated 4-day female    17 testis, mated 4-day male    13 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    8 central nervous system, pupae P8    5 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    4 head, mated 20-day female    2 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    8 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    2 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    3 fat body, white prepupae    4 fat body, pupae P8    1 carcass, larvae L3 wandering    6 carcass, 1-day adult    2 carcass, 4-day adult    5 carcass, 20-day adult    3 ovary, virgin 4-day female    15 ovary, mated 4-day female    17 testis, mated 4-day male    13 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    8 central nervous system, pupae P8    5 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    4 head, mated 20-day female    2 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    8 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    2 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    3 fat body, white prepupae    4 fat body, pupae P8    1 carcass, larvae L3 wandering    6 carcass, 1-day adult    2 carcass, 4-day adult    5 carcass, 20-day adult    3 ovary, virgin 4-day female    15 ovary, mated 4-day female    17 testis, mated 4-day male    13 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    8 central nervous system, pupae P8    5 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    4 head, mated 20-day female    2 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    8 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    2 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    3 fat body, white prepupae    4 fat body, pupae P8    1 carcass, larvae L3 wandering    6 carcass, 1-day adult    2 carcass, 4-day adult    5 carcass, 20-day adult    3 ovary, virgin 4-day female    15 ovary, mated 4-day female    17 testis, mated 4-day male    13 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    13 embryo 02-04hr    8 embryo 04-06hr    8 embryo 06-08hr    8 embryo 08-10hr    10 embryo 10-12hr    12 embryo 12-14hr    7 embryo 14-16hr    5 embryo 16-18hr    3 embryo 18-20hr    2 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    8 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    7 white prepupae new    6 white prepupae 12hr    7 white prepupae 24hr    8 pupae 2d postWPP    6 pupae 3d postWPP    4 pupae 4d postWPP    3 adult male 01day    5 adult male 05day    6 adult male 30day    7 adult female 01day    8 adult female 05day    12 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    13 embryo 02-04hr    8 embryo 04-06hr    8 embryo 06-08hr    8 embryo 08-10hr    10 embryo 10-12hr    12 embryo 12-14hr    7 embryo 14-16hr    5 embryo 16-18hr    3 embryo 18-20hr    2 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    8 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    7 white prepupae new    6 white prepupae 12hr    7 white prepupae 24hr    8 pupae 2d postWPP    6 pupae 3d postWPP    4 pupae 4d postWPP    3 adult male 01day    5 adult male 05day    6 adult male 30day    7 adult female 01day    8 adult female 05day    12 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    13 embryo 02-04hr    8 embryo 04-06hr    8 embryo 06-08hr    8 embryo 08-10hr    10 embryo 10-12hr    12 embryo 12-14hr    7 embryo 14-16hr    5 embryo 16-18hr    3 embryo 18-20hr    2 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    8 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    7 white prepupae new    6 white prepupae 12hr    7 white prepupae 24hr    8 pupae 2d postWPP    6 pupae 3d postWPP    4 pupae 4d postWPP    3 adult male 01day    5 adult male 05day    6 adult male 30day    7 adult female 01day    8 adult female 05day    12 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    13 embryo 02-04hr    8 embryo 04-06hr    8 embryo 06-08hr    8 embryo 08-10hr    10 embryo 10-12hr    12 embryo 12-14hr    7 embryo 14-16hr    5 embryo 16-18hr    3 embryo 18-20hr    2 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    8 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    7 white prepupae new    6 white prepupae 12hr    7 white prepupae 24hr    8 pupae 2d postWPP    6 pupae 3d postWPP    4 pupae 4d postWPP    3 adult male 01day    5 adult male 05day    6 adult male 30day    7 adult female 01day    8 adult female 05day    12 adult female 30day    12 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    13 embryo 02-04hr    8 embryo 04-06hr    8 embryo 06-08hr    8 embryo 08-10hr    10 embryo 10-12hr    12 embryo 12-14hr    7 embryo 14-16hr    5 embryo 16-18hr    3 embryo 18-20hr    2 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    8 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    7 white prepupae new    6 white prepupae 12hr    7 white prepupae 24hr    8 pupae 2d postWPP    6 pupae 3d postWPP    4 pupae 4d postWPP    3 adult male 01day    5 adult male 05day    6 adult male 30day    7 adult female 01day    8 adult female 05day    12 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    13 embryo 02-04hr    8 embryo 04-06hr    8 embryo 06-08hr    8 embryo 08-10hr    10 embryo 10-12hr    12 embryo 12-14hr    7 embryo 14-16hr    5 embryo 16-18hr    3 embryo 18-20hr    2 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    8 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    7 white prepupae new    6 white prepupae 12hr    7 white prepupae 24hr    8 pupae 2d postWPP    6 pupae 3d postWPP    4 pupae 4d postWPP    3 adult male 01day    5 adult male 05day    6 adult male 30day    7 adult female 01day    8 adult female 05day    12 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    13 embryo 02-04hr    8 embryo 04-06hr    8 embryo 06-08hr    8 embryo 08-10hr    10 embryo 10-12hr    12 embryo 12-14hr    7 embryo 14-16hr    5 embryo 16-18hr    3 embryo 18-20hr    2 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    8 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    7 white prepupae new    6 white prepupae 12hr    7 white prepupae 24hr    8 pupae 2d postWPP    6 pupae 3d postWPP    4 pupae 4d postWPP    3 adult male 01day    5 adult male 05day    6 adult male 30day    7 adult female 01day    8 adult female 05day    12 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    13 embryo 02-04hr    8 embryo 04-06hr    8 embryo 06-08hr    8 embryo 08-10hr    10 embryo 10-12hr    12 embryo 12-14hr    7 embryo 14-16hr    5 embryo 16-18hr    3 embryo 18-20hr    2 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    8 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    7 white prepupae new    6 white prepupae 12hr    7 white prepupae 24hr    8 pupae 2d postWPP    6 pupae 3d postWPP    4 pupae 4d postWPP    3 adult male 01day    5 adult male 05day    6 adult male 30day    7 adult female 01day    8 adult female 05day    12 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    27 Schneider line 2 Sg4    17 embryonic 1182-4H    11 embryonic GM2    16 embryonic Kc167    28 embryonic S1    10 embryonic S3    9 leg disc CME L1    12 wing disc CME-W2    13 wing disc ML-DmD8    8 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    25 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    17 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    5 ovary fGS/OSS    13 ovary OSC    15 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (27) Schneider line 2 Sg4    17 embryonic 1182-4H    11 embryonic GM2    16 embryonic Kc167  (28) embryonic S1    10 embryonic S3    9 leg disc CME L1    12 wing disc CME-W2    13 wing disc ML-DmD8    8 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    25 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    17 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    5 ovary fGS/OSS    13 ovary OSC    15 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    27 Schneider line 2 Sg4    17 embryonic 1182-4H    11 embryonic GM2    16 embryonic Kc167    28 embryonic S1    10 embryonic S3    9 leg disc CME L1    12 wing disc CME-W2    13 wing disc ML-DmD8    8 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    25 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    17 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    5 ovary fGS/OSS    13 ovary OSC    15 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    27 Schneider line 2 Sg4    17 embryonic 1182-4H    11 embryonic GM2    16 embryonic Kc167    28 embryonic S1    10 embryonic S3    9 leg disc CME L1    12 wing disc CME-W2    13 wing disc ML-DmD8    8 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    25 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    17 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    5 ovary fGS/OSS    13 ovary OSC    15 ovary OSS    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    27 Schneider line 2 Sg4    17 embryonic 1182-4H    11 embryonic GM2    16 embryonic Kc167    28 embryonic S1    10 embryonic S3    9 leg disc CME L1    12 wing disc CME-W2    13 wing disc ML-DmD8    8 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    25 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    17 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    5 ovary fGS/OSS    13 ovary OSC    15 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  27 Schneider line 2 Sg4    17 embryonic 1182-4H    11 embryonic GM2    16 embryonic Kc167  28 embryonic S1    10 embryonic S3    9 leg disc CME L1    12 wing disc CME-W2    13 wing disc ML-DmD8    8 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    25 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    17 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    5 ovary fGS/OSS    13 ovary OSC    15 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    27 Schneider line 2 Sg4    17 embryonic 1182-4H    11 embryonic GM2    16 embryonic Kc167    28 embryonic S1    10 embryonic S3    9 leg disc CME L1    12 wing disc CME-W2    13 wing disc ML-DmD8    8 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    25 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    17 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    5 ovary fGS/OSS    13 ovary OSC    15 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    27 Schneider line 2 Sg4    17 embryonic 1182-4H    11 embryonic GM2    16 embryonic Kc167    28 embryonic S1    10 embryonic S3    9 leg disc CME L1    12 wing disc CME-W2    13 wing disc ML-DmD8    8 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    25 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    17 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    5 ovary fGS/OSS    13 ovary OSC    15 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    4 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    10 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    4 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    10 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    4 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    10 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    4 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    10 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    4 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    10 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    4 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    10 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    4 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    10 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    4 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    10 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_06 mE1_20_mRNA_expression_cluster_05
External Data & Images
Linkouts	BDGP expression data • SD19581 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0038951 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5380-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal CG5380GD4239 lethal | pupal stage, with Scer\GAL4pnr-MD237 CG5380GD4239 Other Phenotypes Allele neuroanatomy defective | larval stage CG5380GD4239 Phenotype manifest in Allele embryonic/larval neuroblast | larval stage CG5380GD4239 ganglion mother cell | larval stage CG5380GD4239
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of CG5380 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG5380 Class Mutagen Stocks Known lesion CG5380GD4239 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG5380KK100353 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes CG5380NIG.5380R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6190 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4239} NA P{KK100353} NA P{NIG.5380R} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
neurogenesis inferred from mutant phenotype (Neumüller et al., 2011)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
DNA binding inferred from electronic annotation with InterPro:IPR007832 (FlyBase Curators et al., 2004-) DNA-directed RNA polymerase activity inferred from sequence or structural similarity with EMBL:U93869 (FlyBase, 1992-) non-traceable author statement (Prokopenko et al., 2000, Swiss-Prot Project Members, 2002.3.1)
Biological Process
CV term Evidence References
transcription, DNA-dependent inferred from electronic annotation with InterPro:IPR007832 (FlyBase Curators et al., 2004-) transcription from RNA polymerase III promoter non-traceable author statement (Swiss-Prot Project Members, 2002.3.1)
Cellular Component
CV term Evidence References
DNA-directed RNA polymerase III complex inferred from sequence or structural similarity with EMBL:U93869 (FlyBase, 1992-) nucleus non-traceable author statement (Swiss-Prot Project Members, 2002.3.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
CG5380 - 14-3-3ζ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5380 - AnxB10 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5380 - B52 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5380 - Bacc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5380 - CG16817 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5380 - CG33051 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) CG5380 - CG6259 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5380 - CG7911 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5380 - Chd64 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5380 - Crc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5380 - Df31 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5380 - Dlc90F anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5380 - Eno anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5380 - FK506-bp2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5380 - Hop anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5380 - Hsc70Cb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5380 - Jupiter anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5380 - Nacα anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5380 - Nlp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5380 - Pdi anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5380 - Pglym78 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5380 - Prosβ6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5380 - Prx2540-2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5380 - RpS12 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5380 - RpS21 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5380 - Sh3β anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5380 - awd anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5380 - chic anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5380 - cib anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5380 - eIF-5A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5380 - fabp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5380 - kdn anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5380 - robl anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5380 - scf anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5380 - smt3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG5380 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67577 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0038951 DroID - A comprehensive database of gene and protein interactions. • FBgn0038951 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42619
Orthologs
OrthoDB Orthologs (42) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG634WS7 Dipteran inclusive ortholog search EOG63JCDK Insect inclusive ortholog search EOG62FRDC Arthropod inclusive ortholog search EOG651C6J Metazoa inclusive ortholog search EOG6ZPSPJ
Orthologs in Drosophila Species (EOG634WS7)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG5380     Drosophila simulans   Dsim\GD18467 Y   Drosophila sechellia   Dsec\GM23658 Y   Drosophila erecta   Dere\GG12523 Y   Drosophila yakuba   Dyak\GE24046 Y   Drosophila ananassae   Dana\GF16937 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA18836 Y   Drosophila persimilis   Dper\GL24167 Y   Drosophila willistoni   Dwil\GK11949 Y   Drosophila virilis   Dvir\GJ24071 Y   Drosophila mojavensis   Dmoj\GI22278 Y   Drosophila grimshawi   Dgri\GH19703 Y
Orthologs in non-Drosophila Dipterans (EOG63JCDK)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL003786   Anopheles gambiae Malaria mosquito  Agam\AGAP011973   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ017445
Orthologs in non-Dipteran Insects (EOG62FRDC)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC552607   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG011127   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH10642   Atta cephalotes Leafcutter ant  Acep\ACEP10245   Camponotus floridanus Florida carpenter ant  Cflo\CFLO14606   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL20551   Linepithema humile Argentine ant  Lhum\LH14621   Pogonomyrmex barbatus Red harvester ant  Pbar\PB22980   Solenopsis invicta Red fire ant  Sinv\SINV22716   Acyrthosiphon pisum Pea aphid  Apim\ACYPI004562   Bombyx mori Silkmoth  Bmor\BGIBMGA004985   Pediculus humanus Human body louse  Phum\PHUM546030   Tribolium castaneum Red flour beetle  Tcas\TC030601
Orthologs in non-Insect Arthropods (EOG651C6J)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Ccnl1   Daphnia pulex Water flea  Dpux\JGI_V11_324023   Daphnia pulex Water flea  Dpux\gag-pol   Daphnia pulex Water flea  Dpux\matK
Orthologs in non-Arthropod Metazoa (EOG6ZPSPJ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\W09C3.4   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_023807gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_027779gn   Danio rerio Zebrafish  Drer\polr3f   Xenopus tropicalis Western clawed frog  Xtro\polr3f   Gallus gallus Domestic chicken  Ggal\POLR3F   Mus musculus House mouse  Mmus\Polr3f   Rattus norvegicus Norway rat  Rnor\Polr3f   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000038577   Homo sapiens Human  Hsap\POLR3F
Human Orthologs (1)
Gene OMIM HGNC Hsap\POLR3F
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD18467 Drosophila sechellia Dsec\GM23658 Drosophila erecta Dere\GG12523 Drosophila yakuba Dyak\GE24046 Drosophila ananassae Dana\GF16937 Drosophila pseudoobscura pseudoobscura Dpse\GA18836 Drosophila persimilis Dper\GL24167 Drosophila willistoni Dwil\GK11949 Drosophila virilis Dvir\GJ24071 Drosophila mojavensis Dmoj\GI22278 Drosophila grimshawi Dgri\GH19703
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
VDRC	v11228 w1118; P{GD4239}v11228 v11229 w1118; P{GD4239}v11229
Genomic Clones ( 1 )
	BACR09L14 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 5 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	SD19581
Other clones	DPiM_SD19581 MIP22258
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM15990 SD25781
Other clones
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0038951 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42619
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments	The flanking sequence of the P{lacW}btbk09901 insertion maps by BLAST in the region of "CG5380" (the insertion maps 418bp upstream of the AUG codon), and the P{lacW} insertion may therefore affect this gene. <up>Note, at the time of curation CG5380 is computed to be located at 94A, however, in situ hybridisation to polytene chromosomes using the flanking sequence isolated from P{lacW}btbk09901 results in a signal at 47A--47B</up>. (Prokopenko et al., 2000)
Other Comments
	RNAi screen using dsRNA made from templates generated with primers directed against this gene results in chromosome misalignment on the metaphase spindle when assayed in S2 cells in the presence of Cdc27 dsRNA. This phenotype cannot be observed when the screen is performed without Cdc27 dsRNA. (Goshima et al., 2007)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_142772 NM_001260308 RefSeq (Proteins) • NP_651029 NP_001247237 DDBJ / EMBL / GenBank • AAF55978 AAM51101 AFH06555 AY119241 BI637540 Entrez Gene - A searchable database of RefSeq genes. • 42619 UniProtKB/Swiss-Prot • Q9VD25
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • RNA polymerase Rpc34 (IPR007832) RNA polymerase Rpc34-like (IPR016049) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • SD19581
Linkouts
	BioGRID - A database of protein and genetic interactions • 67577 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0038951 DroID - A comprehensive database of gene and protein interactions. • FBgn0038951 DRSC - Results from RNAi screens. • FBgn0038951 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0038951 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5380-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0038951 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42619 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42619 modMine - Data generated by the modENCODE project. • FBgn0038951
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG5380 (Goshima et al., 2007, Keleman et al., 2009.8.5, Japanese National Institute of Genetics, 2012.5.21)
Name Synonym
Secondary FlyBase IDs
References ( 21 )
Generate a list of	All references relating to this gene ( 21 )
List References by type	Research paper  ( 2 ) Supplementary material  ( 7 ) Personal communication to FlyBase  ( 6 ) FlyBase analysis  ( 1 ) Stock list  ( 1 ) Protein sequence record  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2011 Show research papers ...