General Information Symbol Dmel\ Pebp1Species D. melanogaster Name Phosphatidylethanolamine-binding protein 1 Annotation symbol CG18594 Feature type protein_coding_gene FlyBase ID FBgn0038973 Gene Model Status Current Stock availability 3 publicly
available Genomic Location Chromosome (arm) 3R Recombination map Cytogenetic map 94A16-94A16 Sequence location 3R:18,291,756..18,292,401 [+]
Genomic Maps
Summary Information Automatically generated summary
See sections below for more information The gene
Phosphatidylethanolamine-binding protein 1 is referred to in FlyBase by the symbol
Dmel\Pebp1 (CG18594, FBgn0038973). It is a protein_coding_gene from
Drosophila melanogaster . Its
molecular function is unknown. There is experimental evidence that it is involved in the
biological process : regulation of antimicrobial humoral response; defense response to Gram-positive bacterium; defense response to Gram-negative bacterium.
3 alleles are reported . No phenotypic data is available. It has
one annotated transcript and
one annotated polypeptide .
Protein features are: Phosphatidylethanolamine-binding protein PEBP. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of very low expression. Peak expression observed during early larval stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval/adult midgut. Expression at moderate levels in the following post-embryonic organs or tissues: adult hindgut. Comments on Affy2 ProbeSet: ProbeSet 1624979_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG18594. Gene sequence location is
3R:18291756..18292401 .
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FB2013_03
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Detailed Mapping Data
FlyBase Computed Cytological Location
Experimentally Determined Cytological Location
Experimentally Determined Recombination Data
Location Left of (cM) Right of (cM) Notes Gene Model & Products Comments on Gene
Model Gene model reviewed during 5.43
Gene model reviewed during 5.47
Transcript Data Annotated Transcripts Additional Transcript Data
& Comments Reported size (kB) Comments External Data Crossreferences
Polypeptide Data Annotated
Polypeptides Additional Polypeptide
Data & Comments Reported size (kDa) Comments External Data Linkouts Crossreferences
domains - A database of protein families, domains, and functional sites
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank UniProtKB/Swiss-Prot UniProtKB/TrEMBL Mapped Features Mapped Features have been reorganized, please
see this article for details. Additional mapped features and mutations can
be found on GBrowse or related reports. External Data Linkouts Crossreferences Expression Data Transcript Expression
Additional Descriptive Data
Marker for Subcellular Localization CV Term Polypeptide Expression
Additional Descriptive Data
Marker for Subcellular Localization (GO Cellular Component) Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference
FlyAtlas Anatomy Microarray
Linear, scaled to maximum expression level
Tissue
Expression Level
Larval Central Nervous System
9
Larval Midgut
5994.8
Larval Hindgut
44.2
Larval Malpighian Tubules
19.1
Larval Fat Body
12.3
Larval Salivary Gland
12
Larval Trachea
136.075
Larval Carcass
15.025
Adult Head
6.6
Adult Eye
19.75
Adult Brain
1.9
Adult Thoracic-Abdominal Ganglion
4.1
Adult Crop
5
Adult Midgut
5977.5
Adult Hindgut
236.4
Adult Malpighian Tubules
101.1
Adult Fat Body
19.4
Adult Salivary Gland
17.2
Adult Heart
16.1
Adult VirginFemale Spermatheca
15.4
Adult InseminatedFemale Spermatheca
11.2
Adult Ovary
1.4
Adult Testis
2
Adult Male Accessory Gland
8.8
Adult Carcass
21.8
Expression Level Scale
None
Low
Moderate
High
Very high
Linear, scaled to Moderate expression
Tissue
Expression Level
Larval Central Nervous System
9
Larval Midgut
(5994.8)
Larval Hindgut
44.2
Larval Malpighian Tubules
19.1
Larval Fat Body
12.3
Larval Salivary Gland
12
Larval Trachea
136.075
Larval Carcass
15.025
Adult Head
6.6
Adult Eye
19.75
Adult Brain
1.9
Adult Thoracic-Abdominal Ganglion
4.1
Adult Crop
5
Adult Midgut
(5977.5)
Adult Hindgut
236.4
Adult Malpighian Tubules
101.1
Adult Fat Body
19.4
Adult Salivary Gland
17.2
Adult Heart
16.1
Adult VirginFemale Spermatheca
15.4
Adult InseminatedFemale Spermatheca
11.2
Adult Ovary
1.4
Adult Testis
2
Adult Male Accessory Gland
8.8
Adult Carcass
21.8
Expression Level Scale
None
Low
Moderate
High
Linear, scaled to High level expression
Tissue
Expression Level
Larval Central Nervous System
9
Larval Midgut
(5994.8)
Larval Hindgut
44.2
Larval Malpighian Tubules
19.1
Larval Fat Body
12.3
Larval Salivary Gland
12
Larval Trachea
136.075
Larval Carcass
15.025
Adult Head
6.6
Adult Eye
19.75
Adult Brain
1.9
Adult Thoracic-Abdominal Ganglion
4.1
Adult Crop
5
Adult Midgut
(5977.5)
Adult Hindgut
236.4
Adult Malpighian Tubules
101.1
Adult Fat Body
19.4
Adult Salivary Gland
17.2
Adult Heart
16.1
Adult VirginFemale Spermatheca
15.4
Adult InseminatedFemale Spermatheca
11.2
Adult Ovary
1.4
Adult Testis
2
Adult Male Accessory Gland
8.8
Adult Carcass
21.8
Expression Level Scale
None
Low
Moderate
High
Very high
Linear, scaled to Very high expression
Tissue
Expression Level
Larval Central Nervous System
9
Larval Midgut
5994.8
Larval Hindgut
44.2
Larval Malpighian Tubules
19.1
Larval Fat Body
12.3
Larval Salivary Gland
12
Larval Trachea
136.075
Larval Carcass
15.025
Adult Head
6.6
Adult Eye
19.75
Adult Brain
1.9
Adult Thoracic-Abdominal Ganglion
4.1
Adult Crop
5
Adult Midgut
5977.5
Adult Hindgut
236.4
Adult Malpighian Tubules
101.1
Adult Fat Body
19.4
Adult Salivary Gland
17.2
Adult Heart
16.1
Adult VirginFemale Spermatheca
15.4
Adult InseminatedFemale Spermatheca
11.2
Adult Ovary
1.4
Adult Testis
2
Adult Male Accessory Gland
8.8
Adult Carcass
21.8
Expression Level Scale
Very high
log, scaled to maximum expression level
Tissue
Expression Level
Larval Central Nervous System
9
Larval Midgut
5994.8
Larval Hindgut
44.2
Larval Malpighian Tubules
19.1
Larval Fat Body
12.3
Larval Salivary Gland
12
Larval Trachea
136.075
Larval Carcass
15.025
Adult Head
6.6
Adult Eye
19.75
Adult Brain
1.9
Adult Thoracic-Abdominal Ganglion
4.1
Adult Crop
5
Adult Midgut
5977.5
Adult Hindgut
236.4
Adult Malpighian Tubules
101.1
Adult Fat Body
19.4
Adult Salivary Gland
17.2
Adult Heart
16.1
Adult VirginFemale Spermatheca
15.4
Adult InseminatedFemale Spermatheca
11.2
Adult Ovary
1.4
Adult Testis
2
Adult Male Accessory Gland
8.8
Adult Carcass
21.8
Expression Level Scale
None
Low
Moderate
High
Very high
log, scaled to Moderate expression
Tissue
Expression Level
Larval Central Nervous System
9
Larval Midgut
(5994.8)
Larval Hindgut
44.2
Larval Malpighian Tubules
19.1
Larval Fat Body
12.3
Larval Salivary Gland
12
Larval Trachea
136.075
Larval Carcass
15.025
Adult Head
6.6
Adult Eye
19.75
Adult Brain
1.9
Adult Thoracic-Abdominal Ganglion
4.1
Adult Crop
5
Adult Midgut
(5977.5)
Adult Hindgut
236.4
Adult Malpighian Tubules
101.1
Adult Fat Body
19.4
Adult Salivary Gland
17.2
Adult Heart
16.1
Adult VirginFemale Spermatheca
15.4
Adult InseminatedFemale Spermatheca
11.2
Adult Ovary
1.4
Adult Testis
2
Adult Male Accessory Gland
8.8
Adult Carcass
21.8
Expression Level Scale
None
Low
Moderate
High
log, scaled to High level expression
Tissue
Expression Level
Larval Central Nervous System
9
Larval Midgut
(5994.8)
Larval Hindgut
44.2
Larval Malpighian Tubules
19.1
Larval Fat Body
12.3
Larval Salivary Gland
12
Larval Trachea
136.075
Larval Carcass
15.025
Adult Head
6.6
Adult Eye
19.75
Adult Brain
1.9
Adult Thoracic-Abdominal Ganglion
4.1
Adult Crop
5
Adult Midgut
(5977.5)
Adult Hindgut
236.4
Adult Malpighian Tubules
101.1
Adult Fat Body
19.4
Adult Salivary Gland
17.2
Adult Heart
16.1
Adult VirginFemale Spermatheca
15.4
Adult InseminatedFemale Spermatheca
11.2
Adult Ovary
1.4
Adult Testis
2
Adult Male Accessory Gland
8.8
Adult Carcass
21.8
Expression Level Scale
None
Low
Moderate
High
Very high
log, scaled to Very high expression
Tissue
Expression Level
Larval Central Nervous System
9
Larval Midgut
5994.8
Larval Hindgut
44.2
Larval Malpighian Tubules
19.1
Larval Fat Body
12.3
Larval Salivary Gland
12
Larval Trachea
136.075
Larval Carcass
15.025
Adult Head
6.6
Adult Eye
19.75
Adult Brain
1.9
Adult Thoracic-Abdominal Ganglion
4.1
Adult Crop
5
Adult Midgut
5977.5
Adult Hindgut
236.4
Adult Malpighian Tubules
101.1
Adult Fat Body
19.4
Adult Salivary Gland
17.2
Adult Heart
16.1
Adult VirginFemale Spermatheca
15.4
Adult InseminatedFemale Spermatheca
11.2
Adult Ovary
1.4
Adult Testis
2
Adult Male Accessory Gland
8.8
Adult Carcass
21.8
Expression Level Scale
None
Low
Moderate
High
Very high
Heatmap
Tissue
Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass
FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level
Tissue
Adult Expression Level
NA
Head
6.6
NA
Eye
no informative data
NA
Brain
1.9
9
Central Nervous System
NA
NA
Thoracic-Abdominal Ganglion
4.1
NA
Crop
5
5994.8
Midgut
5977.5
no informative data
Hindgut
236.4
no informative data
Malpighian Tubules
no informative data
no informative data
Fat Body
no informative data
no informative data
Salivary Gland
no informative data
NA
Heart
no informative data
no informative data
Trachea
NA
NA
VirginFemale Spermatheca
no informative data
NA
InseminatedFemale Spermatheca
no informative data
NA
Ovary
1.4
NA
Testis
2
NA
Male Accessory Gland
8.8
no informative data
Carcass
no informative data
modENCODE Anatomy RNA-Seq
Linear, scaled to maximum expression level
Tissue
Expression Level
imaginal disc, larvae L3 wandering
85
central nervous system, larvae L3
0
central nervous system, pupae P8
0
head, virgin 1-day female
2
head, virgin 4-day female
0
head, virgin 20-day female
1
head, mated 1-day female
0
head, mated 4-day female
0
head, mated 20-day female
1
head, mated 1-day male
0
head, mated 4-day male
0
head, mated 20-day male
0
salivary gland, larvae L3 wandering
13
salivary gland, white prepupae
5
digestive system, larvae L3 wandering
244
digestive system, 1-day adult
3026
digestive system, 4-day adult
2301
digestive system, 20-day adult
2091
fat body, larvae L3 wandering
1
fat body, white prepupae
1
fat body, pupae P8
18
carcass, larvae L3 wandering
1
carcass, 1-day adult
36
carcass, 4-day adult
11
carcass, 20-day adult
21
ovary, virgin 4-day female
1
ovary, mated 4-day female
1
testis, mated 4-day male
5
accessory gland, mated 4-day male
12
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Linear, scaled to Moderate expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
(85)
central nervous system, larvae L3
0
central nervous system, pupae P8
0
head, virgin 1-day female
2
head, virgin 4-day female
0
head, virgin 20-day female
1
head, mated 1-day female
0
head, mated 4-day female
0
head, mated 20-day female
1
head, mated 1-day male
0
head, mated 4-day male
0
head, mated 20-day male
0
salivary gland, larvae L3 wandering
13
salivary gland, white prepupae
5
digestive system, larvae L3 wandering
(244)
digestive system, 1-day adult
(3026)
digestive system, 4-day adult
(2301)
digestive system, 20-day adult
(2091)
fat body, larvae L3 wandering
1
fat body, white prepupae
1
fat body, pupae P8
18
carcass, larvae L3 wandering
1
carcass, 1-day adult
(36)
carcass, 4-day adult
11
carcass, 20-day adult
21
ovary, virgin 4-day female
1
ovary, mated 4-day female
1
testis, mated 4-day male
5
accessory gland, mated 4-day male
12
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
85
central nervous system, larvae L3
0
central nervous system, pupae P8
0
head, virgin 1-day female
2
head, virgin 4-day female
0
head, virgin 20-day female
1
head, mated 1-day female
0
head, mated 4-day female
0
head, mated 20-day female
1
head, mated 1-day male
0
head, mated 4-day male
0
head, mated 20-day male
0
salivary gland, larvae L3 wandering
13
salivary gland, white prepupae
5
digestive system, larvae L3 wandering
(244)
digestive system, 1-day adult
(3026)
digestive system, 4-day adult
(2301)
digestive system, 20-day adult
(2091)
fat body, larvae L3 wandering
1
fat body, white prepupae
1
fat body, pupae P8
18
carcass, larvae L3 wandering
1
carcass, 1-day adult
36
carcass, 4-day adult
11
carcass, 20-day adult
21
ovary, virgin 4-day female
1
ovary, mated 4-day female
1
testis, mated 4-day male
5
accessory gland, mated 4-day male
12
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
85
central nervous system, larvae L3
0
central nervous system, pupae P8
0
head, virgin 1-day female
2
head, virgin 4-day female
0
head, virgin 20-day female
1
head, mated 1-day female
0
head, mated 4-day female
0
head, mated 20-day female
1
head, mated 1-day male
0
head, mated 4-day male
0
head, mated 20-day male
0
salivary gland, larvae L3 wandering
13
salivary gland, white prepupae
5
digestive system, larvae L3 wandering
244
digestive system, 1-day adult
3026
digestive system, 4-day adult
2301
digestive system, 20-day adult
2091
fat body, larvae L3 wandering
1
fat body, white prepupae
1
fat body, pupae P8
18
carcass, larvae L3 wandering
1
carcass, 1-day adult
36
carcass, 4-day adult
11
carcass, 20-day adult
21
ovary, virgin 4-day female
1
ovary, mated 4-day female
1
testis, mated 4-day male
5
accessory gland, mated 4-day male
12
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Tissue
Expression Level
imaginal disc, larvae L3 wandering
85
central nervous system, larvae L3
0
central nervous system, pupae P8
0
head, virgin 1-day female
2
head, virgin 4-day female
0
head, virgin 20-day female
1
head, mated 1-day female
0
head, mated 4-day female
0
head, mated 20-day female
1
head, mated 1-day male
0
head, mated 4-day male
0
head, mated 20-day male
0
salivary gland, larvae L3 wandering
13
salivary gland, white prepupae
5
digestive system, larvae L3 wandering
244
digestive system, 1-day adult
3026
digestive system, 4-day adult
2301
digestive system, 20-day adult
2091
fat body, larvae L3 wandering
1
fat body, white prepupae
1
fat body, pupae P8
18
carcass, larvae L3 wandering
1
carcass, 1-day adult
36
carcass, 4-day adult
11
carcass, 20-day adult
21
ovary, virgin 4-day female
1
ovary, mated 4-day female
1
testis, mated 4-day male
5
accessory gland, mated 4-day male
12
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
log, scaled to Moderate expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
(85)
central nervous system, larvae L3
0
central nervous system, pupae P8
0
head, virgin 1-day female
2
head, virgin 4-day female
0
head, virgin 20-day female
1
head, mated 1-day female
0
head, mated 4-day female
0
head, mated 20-day female
1
head, mated 1-day male
0
head, mated 4-day male
0
head, mated 20-day male
0
salivary gland, larvae L3 wandering
13
salivary gland, white prepupae
5
digestive system, larvae L3 wandering
(244)
digestive system, 1-day adult
(3026)
digestive system, 4-day adult
(2301)
digestive system, 20-day adult
(2091)
fat body, larvae L3 wandering
1
fat body, white prepupae
1
fat body, pupae P8
18
carcass, larvae L3 wandering
1
carcass, 1-day adult
(36)
carcass, 4-day adult
11
carcass, 20-day adult
21
ovary, virgin 4-day female
1
ovary, mated 4-day female
1
testis, mated 4-day male
5
accessory gland, mated 4-day male
12
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
85
central nervous system, larvae L3
0
central nervous system, pupae P8
0
head, virgin 1-day female
2
head, virgin 4-day female
0
head, virgin 20-day female
1
head, mated 1-day female
0
head, mated 4-day female
0
head, mated 20-day female
1
head, mated 1-day male
0
head, mated 4-day male
0
head, mated 20-day male
0
salivary gland, larvae L3 wandering
13
salivary gland, white prepupae
5
digestive system, larvae L3 wandering
(244)
digestive system, 1-day adult
(3026)
digestive system, 4-day adult
(2301)
digestive system, 20-day adult
(2091)
fat body, larvae L3 wandering
1
fat body, white prepupae
1
fat body, pupae P8
18
carcass, larvae L3 wandering
1
carcass, 1-day adult
36
carcass, 4-day adult
11
carcass, 20-day adult
21
ovary, virgin 4-day female
1
ovary, mated 4-day female
1
testis, mated 4-day male
5
accessory gland, mated 4-day male
12
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
85
central nervous system, larvae L3
0
central nervous system, pupae P8
0
head, virgin 1-day female
2
head, virgin 4-day female
0
head, virgin 20-day female
1
head, mated 1-day female
0
head, mated 4-day female
0
head, mated 20-day female
1
head, mated 1-day male
0
head, mated 4-day male
0
head, mated 20-day male
0
salivary gland, larvae L3 wandering
13
salivary gland, white prepupae
5
digestive system, larvae L3 wandering
244
digestive system, 1-day adult
3026
digestive system, 4-day adult
2301
digestive system, 20-day adult
2091
fat body, larvae L3 wandering
1
fat body, white prepupae
1
fat body, pupae P8
18
carcass, larvae L3 wandering
1
carcass, 1-day adult
36
carcass, 4-day adult
11
carcass, 20-day adult
21
ovary, virgin 4-day female
1
ovary, mated 4-day female
1
testis, mated 4-day male
5
accessory gland, mated 4-day male
12
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Tissue
Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male
modENCODE Development RNA-Seq
Linear, scaled to maximum expression level
Developmental Stage
Expression Level
embryo 00-02hr
1
embryo 02-04hr
2
embryo 04-06hr
3
embryo 06-08hr
2
embryo 08-10hr
2
embryo 10-12hr
2
embryo 12-14hr
2
embryo 14-16hr
21
embryo 16-18hr
111
embryo 18-20hr
339
embryo 20-22hr
828
embryo 22-24hr
653
larva L1
1685
larva L2
1539
larva L3 12hr old
1783
larva L3 puffstage 1-2
899
larva L3 puffstage 3-6
118
larva L3 puffstage 7-9
21
white prepupae new
9
white prepupae 12hr
5
white prepupae 24hr
7
pupae 2d postWPP
4
pupae 3d postWPP
1
pupae 4d postWPP
22
adult male 01day
440
adult male 05day
224
adult male 30day
235
adult female 01day
1217
adult female 05day
512
adult female 30day
731
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Linear, scaled to Moderate expression
Developmental Stage
Expression Level
embryo 00-02hr
1
embryo 02-04hr
2
embryo 04-06hr
3
embryo 06-08hr
2
embryo 08-10hr
2
embryo 10-12hr
2
embryo 12-14hr
2
embryo 14-16hr
21
embryo 16-18hr
(111)
embryo 18-20hr
(339)
embryo 20-22hr
(828)
embryo 22-24hr
(653)
larva L1
(1685)
larva L2
(1539)
larva L3 12hr old
(1783)
larva L3 puffstage 1-2
(899)
larva L3 puffstage 3-6
(118)
larva L3 puffstage 7-9
21
white prepupae new
9
white prepupae 12hr
5
white prepupae 24hr
7
pupae 2d postWPP
4
pupae 3d postWPP
1
pupae 4d postWPP
22
adult male 01day
(440)
adult male 05day
(224)
adult male 30day
(235)
adult female 01day
(1217)
adult female 05day
(512)
adult female 30day
(731)
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Developmental Stage
Expression Level
embryo 00-02hr
1
embryo 02-04hr
2
embryo 04-06hr
3
embryo 06-08hr
2
embryo 08-10hr
2
embryo 10-12hr
2
embryo 12-14hr
2
embryo 14-16hr
21
embryo 16-18hr
(111)
embryo 18-20hr
(339)
embryo 20-22hr
(828)
embryo 22-24hr
(653)
larva L1
(1685)
larva L2
(1539)
larva L3 12hr old
(1783)
larva L3 puffstage 1-2
(899)
larva L3 puffstage 3-6
(118)
larva L3 puffstage 7-9
21
white prepupae new
9
white prepupae 12hr
5
white prepupae 24hr
7
pupae 2d postWPP
4
pupae 3d postWPP
1
pupae 4d postWPP
22
adult male 01day
(440)
adult male 05day
(224)
adult male 30day
(235)
adult female 01day
(1217)
adult female 05day
(512)
adult female 30day
(731)
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Developmental Stage
Expression Level
embryo 00-02hr
1
embryo 02-04hr
2
embryo 04-06hr
3
embryo 06-08hr
2
embryo 08-10hr
2
embryo 10-12hr
2
embryo 12-14hr
2
embryo 14-16hr
21
embryo 16-18hr
111
embryo 18-20hr
339
embryo 20-22hr
828
embryo 22-24hr
653
larva L1
1685
larva L2
1539
larva L3 12hr old
1783
larva L3 puffstage 1-2
899
larva L3 puffstage 3-6
118
larva L3 puffstage 7-9
21
white prepupae new
9
white prepupae 12hr
5
white prepupae 24hr
7
pupae 2d postWPP
4
pupae 3d postWPP
1
pupae 4d postWPP
22
adult male 01day
440
adult male 05day
224
adult male 30day
235
adult female 01day
1217
adult female 05day
512
adult female 30day
731
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Developmental Stage
Expression Level
embryo 00-02hr
1
embryo 02-04hr
2
embryo 04-06hr
3
embryo 06-08hr
2
embryo 08-10hr
2
embryo 10-12hr
2
embryo 12-14hr
2
embryo 14-16hr
21
embryo 16-18hr
111
embryo 18-20hr
339
embryo 20-22hr
828
embryo 22-24hr
653
larva L1
1685
larva L2
1539
larva L3 12hr old
1783
larva L3 puffstage 1-2
899
larva L3 puffstage 3-6
118
larva L3 puffstage 7-9
21
white prepupae new
9
white prepupae 12hr
5
white prepupae 24hr
7
pupae 2d postWPP
4
pupae 3d postWPP
1
pupae 4d postWPP
22
adult male 01day
440
adult male 05day
224
adult male 30day
235
adult female 01day
1217
adult female 05day
512
adult female 30day
731
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
log, scaled to Moderate expression
Developmental Stage
Expression Level
embryo 00-02hr
1
embryo 02-04hr
2
embryo 04-06hr
3
embryo 06-08hr
2
embryo 08-10hr
2
embryo 10-12hr
2
embryo 12-14hr
2
embryo 14-16hr
21
embryo 16-18hr
(111)
embryo 18-20hr
(339)
embryo 20-22hr
(828)
embryo 22-24hr
(653)
larva L1
(1685)
larva L2
(1539)
larva L3 12hr old
(1783)
larva L3 puffstage 1-2
(899)
larva L3 puffstage 3-6
(118)
larva L3 puffstage 7-9
21
white prepupae new
9
white prepupae 12hr
5
white prepupae 24hr
7
pupae 2d postWPP
4
pupae 3d postWPP
1
pupae 4d postWPP
22
adult male 01day
(440)
adult male 05day
(224)
adult male 30day
(235)
adult female 01day
(1217)
adult female 05day
(512)
adult female 30day
(731)
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Developmental Stage
Expression Level
embryo 00-02hr
1
embryo 02-04hr
2
embryo 04-06hr
3
embryo 06-08hr
2
embryo 08-10hr
2
embryo 10-12hr
2
embryo 12-14hr
2
embryo 14-16hr
21
embryo 16-18hr
111
embryo 18-20hr
(339)
embryo 20-22hr
(828)
embryo 22-24hr
(653)
larva L1
(1685)
larva L2
(1539)
larva L3 12hr old
(1783)
larva L3 puffstage 1-2
(899)
larva L3 puffstage 3-6
118
larva L3 puffstage 7-9
21
white prepupae new
9
white prepupae 12hr
5
white prepupae 24hr
7
pupae 2d postWPP
4
pupae 3d postWPP
1
pupae 4d postWPP
22
adult male 01day
(440)
adult male 05day
(224)
adult male 30day
(235)
adult female 01day
(1217)
adult female 05day
(512)
adult female 30day
(731)
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Developmental Stage
Expression Level
embryo 00-02hr
1
embryo 02-04hr
2
embryo 04-06hr
3
embryo 06-08hr
2
embryo 08-10hr
2
embryo 10-12hr
2
embryo 12-14hr
2
embryo 14-16hr
21
embryo 16-18hr
111
embryo 18-20hr
339
embryo 20-22hr
828
embryo 22-24hr
653
larva L1
1685
larva L2
1539
larva L3 12hr old
1783
larva L3 puffstage 1-2
899
larva L3 puffstage 3-6
118
larva L3 puffstage 7-9
21
white prepupae new
9
white prepupae 12hr
5
white prepupae 24hr
7
pupae 2d postWPP
4
pupae 3d postWPP
1
pupae 4d postWPP
22
adult male 01day
440
adult male 05day
224
adult male 30day
235
adult female 01day
1217
adult female 05day
512
adult female 30day
731
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Developmental Stage
Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day
modENCODE Cell Lines RNA-Seq
Linear, scaled to maximum expression level
Cell Line
Expression Level
Schneider line 2 S2R+
3
Schneider line 2 Sg4
1
embryonic 1182-4H
1
embryonic GM2
2
embryonic Kc167
2
embryonic S1
0
embryonic S3
1
leg disc CME L1
1
wing disc CME-W2
2
wing disc ML-DmD8
0
wing disc ML-DmD9
4
wing disc ML-DmD16-c3
1
wing disc ML-DmD21
2
wing disc ML-DmD32
2
haltere disc ML-DmD17-c3
1
eye-antennal disc ML-DmD11
1
antennal disc ML-DmD20-c5
1
mixed discs ML-DmD4-c1
0
CNS ML-DmBG1-c1
2
CNS ML-DmBG2-c2
1
tumorous blood cells mbn2
3
ovary fGS/OSS
1
ovary OSC
0
ovary OSS
0
Expression Level Scale
Very low
Low
Moderate
Linear, scaled to Moderate expression
Cell Line
Expression Level
Schneider line 2 S2R+
3
Schneider line 2 Sg4
1
embryonic 1182-4H
1
embryonic GM2
2
embryonic Kc167
2
embryonic S1
0
embryonic S3
1
leg disc CME L1
1
wing disc CME-W2
2
wing disc ML-DmD8
0
wing disc ML-DmD9
4
wing disc ML-DmD16-c3
1
wing disc ML-DmD21
2
wing disc ML-DmD32
2
haltere disc ML-DmD17-c3
1
eye-antennal disc ML-DmD11
1
antennal disc ML-DmD20-c5
1
mixed discs ML-DmD4-c1
0
CNS ML-DmBG1-c1
2
CNS ML-DmBG2-c2
1
tumorous blood cells mbn2
3
ovary fGS/OSS
1
ovary OSC
0
ovary OSS
0
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Cell Line
Expression Level
Schneider line 2 S2R+
3
Schneider line 2 Sg4
1
embryonic 1182-4H
1
embryonic GM2
2
embryonic Kc167
2
embryonic S1
0
embryonic S3
1
leg disc CME L1
1
wing disc CME-W2
2
wing disc ML-DmD8
0
wing disc ML-DmD9
4
wing disc ML-DmD16-c3
1
wing disc ML-DmD21
2
wing disc ML-DmD32
2
haltere disc ML-DmD17-c3
1
eye-antennal disc ML-DmD11
1
antennal disc ML-DmD20-c5
1
mixed discs ML-DmD4-c1
0
CNS ML-DmBG1-c1
2
CNS ML-DmBG2-c2
1
tumorous blood cells mbn2
3
ovary fGS/OSS
1
ovary OSC
0
ovary OSS
0
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Cell Line
Expression Level
Schneider line 2 S2R+
3
Schneider line 2 Sg4
1
embryonic 1182-4H
1
embryonic GM2
2
embryonic Kc167
2
embryonic S1
0
embryonic S3
1
leg disc CME L1
1
wing disc CME-W2
2
wing disc ML-DmD8
0
wing disc ML-DmD9
4
wing disc ML-DmD16-c3
1
wing disc ML-DmD21
2
wing disc ML-DmD32
2
haltere disc ML-DmD17-c3
1
eye-antennal disc ML-DmD11
1
antennal disc ML-DmD20-c5
1
mixed discs ML-DmD4-c1
0
CNS ML-DmBG1-c1
2
CNS ML-DmBG2-c2
1
tumorous blood cells mbn2
3
ovary fGS/OSS
1
ovary OSC
0
ovary OSS
0
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Cell Line
Expression Level
Schneider line 2 S2R+
3
Schneider line 2 Sg4
1
embryonic 1182-4H
1
embryonic GM2
2
embryonic Kc167
2
embryonic S1
0
embryonic S3
1
leg disc CME L1
1
wing disc CME-W2
2
wing disc ML-DmD8
0
wing disc ML-DmD9
4
wing disc ML-DmD16-c3
1
wing disc ML-DmD21
2
wing disc ML-DmD32
2
haltere disc ML-DmD17-c3
1
eye-antennal disc ML-DmD11
1
antennal disc ML-DmD20-c5
1
mixed discs ML-DmD4-c1
0
CNS ML-DmBG1-c1
2
CNS ML-DmBG2-c2
1
tumorous blood cells mbn2
3
ovary fGS/OSS
1
ovary OSC
0
ovary OSS
0
Expression Level Scale
Very low
Low
Moderate
log, scaled to Moderate expression
Cell Line
Expression Level
Schneider line 2 S2R+
3
Schneider line 2 Sg4
1
embryonic 1182-4H
1
embryonic GM2
2
embryonic Kc167
2
embryonic S1
0
embryonic S3
1
leg disc CME L1
1
wing disc CME-W2
2
wing disc ML-DmD8
0
wing disc ML-DmD9
4
wing disc ML-DmD16-c3
1
wing disc ML-DmD21
2
wing disc ML-DmD32
2
haltere disc ML-DmD17-c3
1
eye-antennal disc ML-DmD11
1
antennal disc ML-DmD20-c5
1
mixed discs ML-DmD4-c1
0
CNS ML-DmBG1-c1
2
CNS ML-DmBG2-c2
1
tumorous blood cells mbn2
3
ovary fGS/OSS
1
ovary OSC
0
ovary OSS
0
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Cell Line
Expression Level
Schneider line 2 S2R+
3
Schneider line 2 Sg4
1
embryonic 1182-4H
1
embryonic GM2
2
embryonic Kc167
2
embryonic S1
0
embryonic S3
1
leg disc CME L1
1
wing disc CME-W2
2
wing disc ML-DmD8
0
wing disc ML-DmD9
4
wing disc ML-DmD16-c3
1
wing disc ML-DmD21
2
wing disc ML-DmD32
2
haltere disc ML-DmD17-c3
1
eye-antennal disc ML-DmD11
1
antennal disc ML-DmD20-c5
1
mixed discs ML-DmD4-c1
0
CNS ML-DmBG1-c1
2
CNS ML-DmBG2-c2
1
tumorous blood cells mbn2
3
ovary fGS/OSS
1
ovary OSC
0
ovary OSS
0
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Cell Line
Expression Level
Schneider line 2 S2R+
3
Schneider line 2 Sg4
1
embryonic 1182-4H
1
embryonic GM2
2
embryonic Kc167
2
embryonic S1
0
embryonic S3
1
leg disc CME L1
1
wing disc CME-W2
2
wing disc ML-DmD8
0
wing disc ML-DmD9
4
wing disc ML-DmD16-c3
1
wing disc ML-DmD21
2
wing disc ML-DmD32
2
haltere disc ML-DmD17-c3
1
eye-antennal disc ML-DmD11
1
antennal disc ML-DmD20-c5
1
mixed discs ML-DmD4-c1
0
CNS ML-DmBG1-c1
2
CNS ML-DmBG2-c2
1
tumorous blood cells mbn2
3
ovary fGS/OSS
1
ovary OSC
0
ovary OSS
0
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Cell Line
Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS
modENCODE Treatments RNA-Seq
Linear, scaled to maximum expression level
Treatment
Expression Level
extended cold, 4-day adult
61
cold shock, 4-day adult
79
heat shock, 4-day adult
697
Cadmium 50 mM 6 hrs, larvae L3
1537
Cadmium 50 mM 12 hrs, larvae L3
444
Cadmium 50 mM 48 hrs, 4-day adult
774
Cadmium 100 mM 48 hrs, 4-day adult
51
Copper 0.5 mM 12 hrs, larvae L3
593
Copper 15 mM 48 hrs, 4-day adult
16
Zinc 5 mM 12 hrs, larvae L3
592
Zinc 4.5 mM 48 hrs, 4-day adult
50
Ethanol 2.5% 3 hrs, larvae L3
88
Ethanol 5% 3 hrs, larvae L3
1124
Ethanol 10% 3 hrs, larvae L3
1302
Caffeine 1.5 mg/ml 4 hrs, larvae L3
737
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
5
Caffeine 25 mg/ml 48 hrs, 4-day adult
77
Paraquat 5 mM 48 hrs, 4-day adult
31
Paraquat 10 mM 48 hrs, 4-day adult
29
Rotenone 2 μg 12 hrs, larvae L3
1475
Rotenone 8 μg 12 hrs, larvae L3
1642
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Linear, scaled to Moderate expression
Treatment
Expression Level
extended cold, 4-day adult
(61)
cold shock, 4-day adult
(79)
heat shock, 4-day adult
(697)
Cadmium 50 mM 6 hrs, larvae L3
(1537)
Cadmium 50 mM 12 hrs, larvae L3
(444)
Cadmium 50 mM 48 hrs, 4-day adult
(774)
Cadmium 100 mM 48 hrs, 4-day adult
(51)
Copper 0.5 mM 12 hrs, larvae L3
(593)
Copper 15 mM 48 hrs, 4-day adult
16
Zinc 5 mM 12 hrs, larvae L3
(592)
Zinc 4.5 mM 48 hrs, 4-day adult
(50)
Ethanol 2.5% 3 hrs, larvae L3
(88)
Ethanol 5% 3 hrs, larvae L3
(1124)
Ethanol 10% 3 hrs, larvae L3
(1302)
Caffeine 1.5 mg/ml 4 hrs, larvae L3
(737)
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
5
Caffeine 25 mg/ml 48 hrs, 4-day adult
(77)
Paraquat 5 mM 48 hrs, 4-day adult
(31)
Paraquat 10 mM 48 hrs, 4-day adult
(29)
Rotenone 2 μg 12 hrs, larvae L3
(1475)
Rotenone 8 μg 12 hrs, larvae L3
(1642)
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Treatment
Expression Level
extended cold, 4-day adult
61
cold shock, 4-day adult
79
heat shock, 4-day adult
(697)
Cadmium 50 mM 6 hrs, larvae L3
(1537)
Cadmium 50 mM 12 hrs, larvae L3
(444)
Cadmium 50 mM 48 hrs, 4-day adult
(774)
Cadmium 100 mM 48 hrs, 4-day adult
51
Copper 0.5 mM 12 hrs, larvae L3
(593)
Copper 15 mM 48 hrs, 4-day adult
16
Zinc 5 mM 12 hrs, larvae L3
(592)
Zinc 4.5 mM 48 hrs, 4-day adult
50
Ethanol 2.5% 3 hrs, larvae L3
88
Ethanol 5% 3 hrs, larvae L3
(1124)
Ethanol 10% 3 hrs, larvae L3
(1302)
Caffeine 1.5 mg/ml 4 hrs, larvae L3
(737)
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
5
Caffeine 25 mg/ml 48 hrs, 4-day adult
77
Paraquat 5 mM 48 hrs, 4-day adult
31
Paraquat 10 mM 48 hrs, 4-day adult
29
Rotenone 2 μg 12 hrs, larvae L3
(1475)
Rotenone 8 μg 12 hrs, larvae L3
(1642)
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Treatment
Expression Level
extended cold, 4-day adult
61
cold shock, 4-day adult
79
heat shock, 4-day adult
697
Cadmium 50 mM 6 hrs, larvae L3
1537
Cadmium 50 mM 12 hrs, larvae L3
444
Cadmium 50 mM 48 hrs, 4-day adult
774
Cadmium 100 mM 48 hrs, 4-day adult
51
Copper 0.5 mM 12 hrs, larvae L3
593
Copper 15 mM 48 hrs, 4-day adult
16
Zinc 5 mM 12 hrs, larvae L3
592
Zinc 4.5 mM 48 hrs, 4-day adult
50
Ethanol 2.5% 3 hrs, larvae L3
88
Ethanol 5% 3 hrs, larvae L3
1124
Ethanol 10% 3 hrs, larvae L3
1302
Caffeine 1.5 mg/ml 4 hrs, larvae L3
737
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
5
Caffeine 25 mg/ml 48 hrs, 4-day adult
77
Paraquat 5 mM 48 hrs, 4-day adult
31
Paraquat 10 mM 48 hrs, 4-day adult
29
Rotenone 2 μg 12 hrs, larvae L3
1475
Rotenone 8 μg 12 hrs, larvae L3
1642
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Treatment
Expression Level
extended cold, 4-day adult
61
cold shock, 4-day adult
79
heat shock, 4-day adult
697
Cadmium 50 mM 6 hrs, larvae L3
1537
Cadmium 50 mM 12 hrs, larvae L3
444
Cadmium 50 mM 48 hrs, 4-day adult
774
Cadmium 100 mM 48 hrs, 4-day adult
51
Copper 0.5 mM 12 hrs, larvae L3
593
Copper 15 mM 48 hrs, 4-day adult
16
Zinc 5 mM 12 hrs, larvae L3
592
Zinc 4.5 mM 48 hrs, 4-day adult
50
Ethanol 2.5% 3 hrs, larvae L3
88
Ethanol 5% 3 hrs, larvae L3
1124
Ethanol 10% 3 hrs, larvae L3
1302
Caffeine 1.5 mg/ml 4 hrs, larvae L3
737
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
5
Caffeine 25 mg/ml 48 hrs, 4-day adult
77
Paraquat 5 mM 48 hrs, 4-day adult
31
Paraquat 10 mM 48 hrs, 4-day adult
29
Rotenone 2 μg 12 hrs, larvae L3
1475
Rotenone 8 μg 12 hrs, larvae L3
1642
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
log, scaled to Moderate expression
Treatment
Expression Level
extended cold, 4-day adult
(61)
cold shock, 4-day adult
(79)
heat shock, 4-day adult
(697)
Cadmium 50 mM 6 hrs, larvae L3
(1537)
Cadmium 50 mM 12 hrs, larvae L3
(444)
Cadmium 50 mM 48 hrs, 4-day adult
(774)
Cadmium 100 mM 48 hrs, 4-day adult
(51)
Copper 0.5 mM 12 hrs, larvae L3
(593)
Copper 15 mM 48 hrs, 4-day adult
16
Zinc 5 mM 12 hrs, larvae L3
(592)
Zinc 4.5 mM 48 hrs, 4-day adult
(50)
Ethanol 2.5% 3 hrs, larvae L3
(88)
Ethanol 5% 3 hrs, larvae L3
(1124)
Ethanol 10% 3 hrs, larvae L3
(1302)
Caffeine 1.5 mg/ml 4 hrs, larvae L3
(737)
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
5
Caffeine 25 mg/ml 48 hrs, 4-day adult
(77)
Paraquat 5 mM 48 hrs, 4-day adult
31
Paraquat 10 mM 48 hrs, 4-day adult
29
Rotenone 2 μg 12 hrs, larvae L3
(1475)
Rotenone 8 μg 12 hrs, larvae L3
(1642)
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Treatment
Expression Level
extended cold, 4-day adult
61
cold shock, 4-day adult
79
heat shock, 4-day adult
(697)
Cadmium 50 mM 6 hrs, larvae L3
(1537)
Cadmium 50 mM 12 hrs, larvae L3
(444)
Cadmium 50 mM 48 hrs, 4-day adult
(774)
Cadmium 100 mM 48 hrs, 4-day adult
51
Copper 0.5 mM 12 hrs, larvae L3
(593)
Copper 15 mM 48 hrs, 4-day adult
16
Zinc 5 mM 12 hrs, larvae L3
(592)
Zinc 4.5 mM 48 hrs, 4-day adult
50
Ethanol 2.5% 3 hrs, larvae L3
88
Ethanol 5% 3 hrs, larvae L3
(1124)
Ethanol 10% 3 hrs, larvae L3
(1302)
Caffeine 1.5 mg/ml 4 hrs, larvae L3
(737)
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
5
Caffeine 25 mg/ml 48 hrs, 4-day adult
77
Paraquat 5 mM 48 hrs, 4-day adult
31
Paraquat 10 mM 48 hrs, 4-day adult
29
Rotenone 2 μg 12 hrs, larvae L3
(1475)
Rotenone 8 μg 12 hrs, larvae L3
(1642)
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Treatment
Expression Level
extended cold, 4-day adult
61
cold shock, 4-day adult
79
heat shock, 4-day adult
697
Cadmium 50 mM 6 hrs, larvae L3
1537
Cadmium 50 mM 12 hrs, larvae L3
444
Cadmium 50 mM 48 hrs, 4-day adult
774
Cadmium 100 mM 48 hrs, 4-day adult
51
Copper 0.5 mM 12 hrs, larvae L3
593
Copper 15 mM 48 hrs, 4-day adult
16
Zinc 5 mM 12 hrs, larvae L3
592
Zinc 4.5 mM 48 hrs, 4-day adult
50
Ethanol 2.5% 3 hrs, larvae L3
88
Ethanol 5% 3 hrs, larvae L3
1124
Ethanol 10% 3 hrs, larvae L3
1302
Caffeine 1.5 mg/ml 4 hrs, larvae L3
737
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
5
Caffeine 25 mg/ml 48 hrs, 4-day adult
77
Paraquat 5 mM 48 hrs, 4-day adult
31
Paraquat 10 mM 48 hrs, 4-day adult
29
Rotenone 2 μg 12 hrs, larvae L3
1475
Rotenone 8 μg 12 hrs, larvae L3
1642
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Treatment
Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
A cluster of genes with similar mRNA expression dynamics across development.
External Data & Images
Linkouts
- Cell culture data for RNAi and other high-throughput technologies
- Adult expression by tissue, using Affymetrix Dros2 array
Alleles & Phenotypes Summary of Allele Phenotypes Classical Alleles ( 0 ) For All Classical Alleles Show Allele of
Pebp1 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs
( 3 ) For All Alleles Carried on Transgenic
Constructs Show Aneuploid Aberrations Disrupted in Transgenic Constructs & Insertions
Transgenic Constructs Insertions Gene Ontology: Function, Process
& Cellular Component ( 3 unique terms ) Terms Based on
Experimental Evidence ( 3 terms ) Molecular Function ( 0 terms) Biological Process inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
Cellular Component ( 0 terms) Terms Based on Predictions or
Assertions ( 0 terms ) Sequence Ontology: Class of Gene Interactions & Pathways
Summary of Physical Interactions
protein-protein anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
Summary of Genetic Interactions Interacts with Please look at the allele data
for full details of the genetic interactions
External Data Linkouts
- A database of protein and genetic interactions
- DPiM, Drosophila Protein interaction Map
- A comprehensive database of gene and protein interactions.
Protein-protein interactions (PPI) from both known and predicted PPI data sets.
Orthologs
OrthoDB Orthologs (26)
- based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
OrthoDB orthology group searches
Drosophila inclusive ortholog search
Dipteran inclusive ortholog search
No orthologs identified
Insect inclusive ortholog search
No orthologs identified
Arthropod inclusive ortholog search
No orthologs identified
Metazoa inclusive ortholog search
Orthologs in Drosophila Species
(EOG6NS3Z2 )
Drosophila melanogaster
fruit fly
Drosophila pseudoobscura pseudoobscura
Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa
(EOG6DVJFV )
Caenorhabditis elegans
Nematode
Y
Strongylocentrotus purpuratus
Purple sea urchin
Y
Strongylocentrotus purpuratus
Purple sea urchin
Y
Strongylocentrotus purpuratus
Purple sea urchin
Y
Strongylocentrotus purpuratus
Purple sea urchin
Y
Strongylocentrotus purpuratus
Purple sea urchin
Y
Xenopus tropicalis
Western clawed frog
Y
Gallus gallus
Domestic chicken
Y
Mus musculus
House mouse
Y
Mus musculus
House mouse
Y
Rattus norvegicus
Norway rat
Y
Human Orthologs (1)AAA Orthologs (10)
based on analysis using Dmel annotation version 4.3
Drosophila pseudoobscura pseudoobscura
Stocks & Reagents Stocks Listed in FlyBase ( 3 )Bloomington VDRC Genomic Clones ( 2 )Please Note FlyBase no
longer curates genomic clone accessions so this list
may not be complete
cDNA Clones ( 49 )Please Note This section lists
cDNAs and ESTs that fall within the genomic extent
of the gene model, which may include cDNAs and ESTs
of genes within introns, or of overlapping genes.
Please see
GBrowse for alignment of the cDNAs and ESTs
to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones Other clones cDNA Clones, End Sequenced
(ESTs) BDGP DGC clones Other clones RNAi & Array Information Linkouts
- Results from RNAi screens.
- GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
Antibody Information
Other Information Discoverer Etymology Identification Relationship to Other Genes Source for database identity of Source for identity of: Pebp1 CG18594
Source for database merge of Source for merge of: CG18594 BcDNA:LP12095
Additional comments Source for merge of CG18594 BcDNA:LP12095 was a shared cDNA (date:030728).
Other Comments External Crossreferences & Linkouts
Sequence Crossreferences
- A searchable database of RefSeq genes.
Other Crossreferences
domains - A database of protein families, domains, and functional sites
- Patterns of gene expression in Drosophila embryogenesis
Linkouts
- A database of protein and genetic interactions
- DPiM, Drosophila Protein interaction Map
- A comprehensive database of gene and protein interactions.
- Results from RNAi screens.
- Cell culture data for RNAi and other high-throughput technologies
- Adult expression by tissue, using Affymetrix Dros2 array
- Integrated genomics database for Drosophila, Anopheles, and C.elegans
- GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
Protein-protein interactions (PPI) from both known and predicted PPI data sets.
- Data generated by the modENCODE project.
Synonyms & Secondary IDs
( 6 )Reported As Symbol Synonym CG18594
(
Chamilos et al., 2008 ,
Reumer et al., 2009 ,
Rautureau et al., 2009 ,
Rautureau et al., 2006 ,
Keleman et al., 2009.8.5 ,
Carpenter et al., 2009 )
Name Synonym Phosphatidylethanolamine-binding protein 1
Secondary FlyBase
IDs References ( 19 )Research paper Carpenter et al., 2009, PLoS ONE 4(8): e6838The transcriptional response of Drosophila melanogaster to infection with the sigma virus (Rhabdoviridae). [FBrf0208625] Rautureau et al., 2009, Arch. Insect Biochem. Physiol. 71(2): 55--69Expression and characterization of the PEBP homolog genes from Drosophila. [FBrf0208002] Reumer et al., 2009, Dev. Comp. Immunol. 33(11): 1186--1195Unraveling the protective effect of a Drosophila phosphatidylethanolamine-binding protein upon bacterial infection by means of proteomics. [FBrf0208656] Chamilos et al., 2008, Proc. Natl. Acad. Sci. U.S.A. 105(27): 9367--9372Drosophila melanogaster as a model host to dissect the immunopathogenesis of zygomycosis. [FBrf0207383] Rautureau et al., 2006, Protein Expr. Purif. 48(1): 90--97Cloning, high yield over-expression, purification, and characterization of CG18594, a new PEBP/RKIP family member from Drosophila melanogaster. [FBrf0193724] Vierstraete et al., 2004, Proc. Natl. Acad. Sci. U.S.A. 101(2): 470--475A proteomic approach for the analysis of instantly released wound and immune proteins in Drosophila melanogaster hemolymph. [FBrf0168012] Vierstraete et al., 2004, Biochem. Biophys. Res. Commun. 317(4): 1052--1060The instantly released Drosophila immune proteome is infection-specific. [FBrf0174382] de Morais Guedes et al., 2003, Biochem. Biophys. Res. Commun. 312(3): 545--554Drosophila melanogaster larval hemolymph protein mapping. [FBrf0167337] Supplementary material Guruharsha et al., 2011, Cell 147(3): Table S3. [FBrf0218395] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452] Personal communication to FlyBase Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi CenterRNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Mintseris et al., 2009.11.23, DPiM: the Drosophila Protein Interaction Mapping projectDPiM: the Drosophila Protein Interaction Mapping project [FBrf0209452] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi CenterRNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Ryder, 2004.4.26, Exelixis CG deletion data.Exelixis CG deletion data. [FBrf0184335] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file)Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078] FlyBase analysis FlyBase, 1996-, FlyBase inference based on genome sequence analysis.FlyBase inference based on genome sequence analysis. [FBrf0104946] Website Fisher et al., 2012, BDGP insitu homepageBDGP insitu homepage [FBrf0219073]