FB2021_06, released December 14, 2021
Gene: Dmel\Nrx-1
Gene: Dmel\Nrx-1
neurexin, dnrx, Nrx, dnrx1, nrx1
ligand of neuroligins involved in development and function of synaptic architecture in the brain and neuromuscular junction - glutamergic synapse
Please see the JBrowse view of Dmel\Nrx-1 for information on other features
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Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Gene model reviewed during 5.47
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.55
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Nrx-1 using the Feature Mapper tool.
Nrx-1 transcripts are enriched in brain and ventral nerve cord neurons starting at embryonic stage 14 and are absent from muscle. They are also detected in small subsets of peripheral nervous system neurons.
Nrx-1 transcripts are widely expressed in early embryos. As embryos develop, it is enriched in the brain and ventral nerve cord and is expressed in many, if not all, CNS neurons.
Nrx-1 protein is observed in the brain and ventral nerve cord starting at embryonic stage 14 and in third instar larvae. It is localized in the CNS neuropil and axonal tracts and motor axons. It is found in type I boutons of the larval body wall muscles. Nrx-1 protein is concentrated at active zones in neuromuscular junctions but also extends into periactive zones.
Nrx-1 protein expression is detected in the nervous system in embryos, larvae, and adults. Strong expression is observed in embryos along the longitudinal tracts of the ventral nerve cord and brain with weaker expression in the commissures of the ventral nerve cord. In adults, strong expression is observed in the medulla, lobula, lobula plate,mushroom body, and antennal lobe.
GBrowse - Visual display of RNA-Seq signals
View Dmel\Nrx-1 in GBrowse 23-74
3-77.4
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
monoclonal
Source for identity of: Nrx-1 CG7050
Loss of Nrx-1 leads to defects in rhodopsin maturation, as a consequence of a reduction in chromophore levels. Neurexin interacts with apolipoprotein I (ApoLI) and is required for the appropriate level of ApoLI and ApoLII proteins.
