FlyBase Gene Report: Dmel\Nrx-1

General Information

Symbol

Dmel\Nrx-1

Species

D. melanogaster

Name

Neurexin 1

Annotation Symbol

CG7050

Feature Type

protein_coding_gene

FlyBase ID

FBgn0038975

Gene Model Status

Current

Stock Availability

17 publicly available

Gene Summary

Neurexin 1 (Nrx-1) encodes a transmembrane synaptic adhesive molecule that regulates the synaptic architecture and function in the brain and neuromuscular junction. It contributes to synaptic growth, transmission, synaptic formation and also regulation of learning and memory, locomotion and visual function. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
UniProtKB
Interactive Fly

Also Known As

dnrx, neurexin, nrx, nrx1, dnrx1

Key Links

Genomic Location

Cytogenetic map

94A16-94B1

Sequence location

3R:22,468,512..22,486,969 [+]

Recombination map

3-75

RefSeq locus

NT_033777 REGION:22468512..22486969

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (26 terms)

Molecular Function (5 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

enables apolipoprotein binding

inferred from physical interaction with FLYBASE:apolpp; FB:FBgn0087002

(Tian et al., 2013)

enables neurexin family protein binding

inferred from physical interaction with UniProtKB:Q9VIC7

(Banerjee et al., 2017)

enables neuroligin family protein binding

inferred from physical interaction with FLYBASE:Nlg2; FB:FBgn0031866

(Chen et al., 2012)

enables protein binding

inferred from physical interaction with FLYBASE:CASK; FB:FBgn0013759

(Sun et al., 2009)

enables protein kinase binding

inferred from physical interaction with UniProtKB:Q24210

(Sun et al., 2009)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (16 terms)

Terms Based on Experimental Evidence (16 terms)

CV Term

Evidence

References

involved_in associative learning

inferred from direct assay

(Zeng et al., 2007)

involved_in chemical synaptic transmission

inferred from direct assay

(Li et al., 2007)

involved_in locomotion

inferred from mutant phenotype

(Sun et al., 2009)

involved_in neuroligin clustering involved in postsynaptic membrane assembly

inferred from mutant phenotype

(Banerjee et al., 2017)

involved_in neuromuscular synaptic transmission

inferred from mutant phenotype

(Sun et al., 2009)

inferred from mutant phenotype

(Chen et al., 2012)

involved_in positive regulation of synaptic vesicle endocytosis

inferred from mutant phenotype

(Sun et al., 2009)

inferred from genetic interaction with FLYBASE:CASK; FB:FBgn0013759

(Sun et al., 2009)

involved_in presynaptic membrane assembly

inferred from mutant phenotype

(Zweier et al., 2009)

involved_in regulation of locomotion

inferred from mutant phenotype

(Sun et al., 2009)

inferred from genetic interaction with FLYBASE:CASK; FB:FBgn0013759

(Sun et al., 2009)

involved_in regulation of neuromuscular synaptic transmission

inferred from mutant phenotype

(Sun et al., 2009)

inferred from genetic interaction with FLYBASE:CASK; FB:FBgn0013759

(Sun et al., 2009)

involved_in regulation of terminal button organization

inferred from mutant phenotype

(Sun et al., 2009)

involved_in synapse assembly

inferred from direct assay

(Zeng et al., 2007)

involved_in synapse organization

inferred from mutant phenotype

(Pandey et al., 2017)

inferred from direct assay

(Li et al., 2007)

involved_in synaptic assembly at neuromuscular junction

inferred from mutant phenotype

(Banerjee et al., 2017, Chen et al., 2012)

involved_in synaptic vesicle endocytosis

inferred from mutant phenotype

(Sun et al., 2009)

involved_in terminal button organization

inferred from mutant phenotype

(Zweier et al., 2009)

involved_in vitamin A transport

inferred from mutant phenotype

(Tian et al., 2013)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (5 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

located_in neuromuscular junction

inferred from direct assay

(Chen et al., 2010)

inferred from direct assay

(Sun et al., 2009)

located_in presynaptic membrane

inferred from direct assay

(Banerjee et al., 2017)

located_in terminal bouton

inferred from direct assay

(Pandey et al., 2017)

part_of trans-synaptic protein complex

inferred from physical interaction with FLYBASE:Nlg1; FB:FBgn0051146

(Banerjee et al., 2017)

located_in type I terminal bouton

inferred from mutant phenotype

(Sun et al., 2009)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

Protein Family (UniProt)

Belongs to the neurexin family. (Q3KN41)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Protein Function (UniProtKB)

Neuronal cell adhesion protein involved in synapse formation, development of synaptic active zones, synaptic regulation and visual function (PubMed:17498701, PubMed:17785181, PubMed:19379781, PubMed:20559439, PubMed:22864612, PubMed:23352167, PubMed:26201245, PubMed:26471740). Plays a role in cell adhesion between the pre- and the postsynaptic cell (PubMed:17785181). Required for proper proliferation of synaptic boutons during larval development, a process necessary for coordinated matching of pre-and postsynaptic compartments (PubMed:17785181). Promotes presynaptic active zone formation and neurotransmitter release (PubMed:20559439). Spn/Spinophilin fine-tunes nrx-1/nlg1 signaling at the pre-synapse to control active zone number and functionality and thereby optimizing action potential-induced exocytosis (PubMed:26471740). Required for synapse formation in central nervous system (PubMed:17498701). By regulating synapse formation, may play a role in larval associative learning (PubMed:17498701, PubMed:19379781). Together with RhoGAP100F/syd-1, controls synapse formation at the neuromuscular junction (PubMed:22864612). Essential for synaptic vesicle cycling, which plays critical roles in neurotransmission at neuromuscular junctions (NMJ) (PubMed:19379781). Regulated and restricts formation of glutamate receptor clusters (PubMed:20559439). Mediates retinoid transport and subsequent rhodopsin maturation and may regulate lipoprotein function; thereby playing a role in vision (PubMed:23352167). Regulates sleep, circadian rhythm and synaptic plasticity (PubMed:26201245). Together with CASK, required for locomotion (PubMed:19379781).

(UniProt, Q3KN41)

Summary (Interactive Fly)

ligand of neuroligins involved in development and function of synaptic architecture in the brain and neuromuscular junction - glutamergic synapse

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Nrx-1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q3KN41)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

PDB - An information portal to biological macromolecular structures

4XHV

Comments on Gene Model

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Gene model reviewed during 5.47

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.55

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Nrx-1-RA

FBtr0084256

NM_079725

6719

1837

Nrx-1-RB

FBtr0301485

NM_001170216

6290

1840

Nrx-1-RC

FBtr0334607

NM_001275908

6619

1837

Nrx-1-RD

FBtr0334608

NM_001275909

6628

1840

Nrx-1-RE

FBtr0334609

NM_001275910

6583

1825

Nrx-1-RF

FBtr0334610

NM_001275911

6649

1847

Nrx-1-RG

FBtr0334611

NM_001275912

6451

1525

Nrx-1-RH

FBtr0334612

NM_001275913

9353

1840

Nrx-1-RI

FBtr0345228

NM_001300538

9643

1840

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Nrx-1-PA

FBpp0083649

199.3

1837

7.15

FBpp0290700

199.6

1840

7.15

FBpp0306674

199.3

1837

7.15

FBpp0306675

199.6

1840

7.15

FBpp0306676

197.9

1825

7.15

FBpp0306677

200.4

1847

7.20

FBpp0306678

167.4

1525

6.96

FBpp0306679

199.6

1840

7.15

FBpp0311420

199.6

1840

7.15

Q3KN41

NP_001287467

AHN57466

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1837 aa isoforms: Nrx-1-PA, Nrx-1-PC

1840 aa isoforms: Nrx-1-PB, Nrx-1-PD, Nrx-1-PH, Nrx-1-PI

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Interacts (via C-terminal PDZ binding motif) with CASK (via PDZ domain) (PubMed:19379781). Interacts (via cytoplasmic domain) with apolpp/ApoLI; the interaction supports apolpp/ApoLI protein stability (PubMed:23352167). Interact (via cytoplasmic domain) with Spn/Spinophilin (PubMed:26471740). Interacts with RhoGAP100F/Syd-1 (via PDZ domain); RhoGAP100F/Syd-1 may recruit Nrx-1 to the presynaptic active zone (PubMed:22864612).

(UniProt, Q3KN41)

Domain

The intracellular region is required for chromophore generation and subsequent rhodopsin 1 maturation.

(UniProt, Q3KN41)

Crossreferences

InterPro - A database of protein families, domains and functional sites

PDB - An information portal to biological macromolecular structures

4XHV

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Nrx-1 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.69

Transcript Expression

expression microarray

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | male

(Arbeitman et al., 2004)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 5

organism | ubiquitous

(Zeng et al., 2007)

embryonic stage 9 -- 11

presumptive embryonic/larval central nervous system

(Zeng et al., 2007)

embryonic stage 14 -- 15

presumptive embryonic/larval central nervous system

(Li et al., 2007)

embryonic stage 14 -- 17

larval ventral nerve cord

(Li et al., 2007, Zeng et al., 2007)

larval brain

(Zeng et al., 2007)

embryonic stage 16 -- 17

larval brain

(Li et al., 2007)

larval central nervous system

(Li et al., 2007)

larval peripheral nervous system

(Li et al., 2007)

larval stage

larval ventral nerve cord

(Zeng et al., 2007)

larval brain

(Zeng et al., 2007)

Additional Descriptive Data

Nrx-1 transcripts are enriched in brain and ventral nerve cord neurons starting at embryonic stage 14 and are absent from muscle. They are also detected in small subsets of peripheral nervous system neurons.

(Li et al., 2007)

Nrx-1 transcripts are widely expressed in early embryos. As embryos develop, it is enriched in the brain and ventral nerve cord and is expressed in many, if not all, CNS neurons.

(Zeng et al., 2007)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 14 -- 15

presumptive embryonic/larval central nervous system

(Li et al., 2007)

embryonic stage 14 -- 17

larval ventral nerve cord

(Zeng et al., 2007)

larval brain

(Zeng et al., 2007)

embryonic stage 16 -- 17

larval brain

(Li et al., 2007)

larval ventral nerve cord

(Li et al., 2007)

larval central nervous system

(Li et al., 2007)

neuron

• axon

(Li et al., 2007)

larval stage

larval longitudinal connective

(Zeng et al., 2007)

larval ventral nerve cord

(Zeng et al., 2007)

larval brain

(Zeng et al., 2007)

third instar larval stage

embryonic/larval neuromuscular junction

(Li et al., 2007)

embryonic/larval hypodermal muscle cell

• neuromuscular junction

(Li et al., 2007)

NMJ bouton

(Li et al., 2007)

type I bouton

(Li et al., 2007)

neuron

• type I terminal bouton

(Li et al., 2007)

wandering third instar larval stage

neuropil of larval central nervous system

(Sun et al., 2009)

adult stage

adult brain

(Tian et al., 2013, Zeng et al., 2007)

retina

(Tian et al., 2013)

rhabdomere of eye photoreceptor cell

(Tian et al., 2013)

medulla

(Zeng et al., 2007)

lobula

(Zeng et al., 2007)

lobula plate

(Zeng et al., 2007)

adult mushroom body

(Zeng et al., 2007)

adult antennal lobe

(Zeng et al., 2007)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

(Tian et al., 2013)

retina

(Tian et al., 2013)

Additional Descriptive Data

Nrx-1-protein is concentrated at neuropil of the larval brain and nerve cord where it is co-expressed with CASK.

(Sun et al., 2009)

Nrx-1 protein is observed in the brain and ventral nerve cord starting at embryonic stage 14 and in third instar larvae. It is localized in the CNS neuropil and axonal tracts and motor axons. It is found in type I boutons of the larval body wall muscles. Nrx-1 protein is concentrated at active zones in neuromuscular junctions but also extends into periactive zones.

(Li et al., 2007)

Nrx-1 protein expression is detected in the nervous system in embryos, larvae, and adults. Strong expression is observed in embryos along the longitudinal tracts of the ventral nerve cord and brain with weaker expression in the commissures of the ventral nerve cord. In adults, strong expression is observed in the medulla, lobula, lobula plate,mushroom body, and antennal lobe.

(Zeng et al., 2007)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in neuromuscular junction

inferred from direct assay

(Chen et al., 2010)

inferred from direct assay

(Sun et al., 2009)

located_in presynaptic membrane

inferred from direct assay

(Banerjee et al., 2017)

located_in terminal bouton

inferred from direct assay

(Pandey et al., 2017)

part_of trans-synaptic protein complex

inferred from physical interaction with FLYBASE:Nlg1; FB:FBgn0051146

(Banerjee et al., 2017)

located_in type I terminal bouton

inferred from mutant phenotype

(Sun et al., 2009)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Nrx-1 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Nrx-1

View exonic expression by tissue for Dmel\Nrx-1

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42646/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0038975

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0038975

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0038975

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7050

Flygut - An atlas of the Drosophila adult midgut

FBgn0038975

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 19 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 28 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Nrx-1

Transgenic constructs containing regulatory region of Nrx-1

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(3R)5C1

(Li et al., 2007)

Df(3R)Exel6191

(Chen et al., 2010, Ryder, 2004.4.26)

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

partially lethal - majority die

Nrx-1²⁷³

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

viable (with Df(3R)5C1)

Nrx-1²⁷³

viable (with Df(3R)Exel6191)

Sterility

Allele

fertile

fertile, with Scer\GAL4^{Nrx-1-MI10278-TG4.1}, Zzzz\VHH^{NbALFA.UAS.mScarlet-I}

Nrx-1^{20xUAS.Tag:ALFA}

fertile (with Df(3R)Exel6191)

Nrx-1^Δ83

Other Phenotypes

Allele

abnormal learning

Nrx-1^Δ83

abnormal learning | adult stage

Nrx-1^HP35068

abnormal learning | adult stage | adult stage | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

Nrx-1^JF02652

abnormal learning | adult stage | adult stage | RU486 conditional, with Scer\GAL4^{Mef2.247.Switch}

Nrx-1^JF02652

abnormal locomotor behavior | late third instar larval stage

Nrx-1^Δ83

abnormal memory | adult stage | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

Nrx-1^JF02652

abnormal memory | adult stage | RU486 conditional, with Scer\GAL4^{Mef2.247.Switch}

Nrx-1^JF02652

abnormal neuroanatomy, with Scer\GAL4^elav-C155

Nrx-1^UAS.cLa

abnormal neuroanatomy, with Scer\GAL4^futsch-C380

Nrx-1^UAS.cLa

abnormal neuroanatomy (with Df(3R)5C1)

Nrx-1²⁷³

abnormal neuroanatomy | adult stage

abnormal neuroanatomy | adult stage, with Scer\GAL4^GMR31C06

Nrx-1^HMS00403

abnormal neuroanatomy | adult stage (with Nrx-1²⁷³)

Nrx-1^Δ83

abnormal neuroanatomy | adult stage (with Nrx-1^Δ83)

Nrx-1²⁷³

abnormal neuroanatomy | adult stage | somatic clone

Nrx-1²⁷³

abnormal neuroanatomy | embryonic stage, with Scer\GAL4^elav.PLu

Nrx-1^RNAi.UAS

abnormal neuroanatomy | embryonic stage (with Df(3R)Exel6191)

Nrx-1³¹³

abnormal neuroanatomy | larval stage

abnormal neuroanatomy | larval stage, with Nrx-1^20xUAS.cVa, Scer\GAL4^BG380

Nrx-1²⁷³

abnormal neuroanatomy | larval stage, with Nrx-1^{20xUAS.Tag:ALFA}, Scer\GAL4^BG380

Nrx-1²⁷³

abnormal neuroanatomy | larval stage, with Nrx-1²⁷³, Scer\GAL4^BG380

abnormal neuroanatomy | larval stage, with Nrx-1^{PDZ.UAS.NbALFA}, Scer\GAL4^BG380

Nrx-1^ΔPDZ-AT

abnormal neuroanatomy | larval stage, with Nrx-1^UAS.GFP, Scer\GAL4^BG380

Nrx-1²⁷³

abnormal neuroanatomy | larval stage, with Nrx-1^ΔPDZ-AT, Scer\GAL4^BG380

Nrx-1^{PDZ.UAS.NbALFA}

abnormal neuroanatomy | larval stage, with Scer\GAL4^elav.PU

Nrx-1^UAS.cZa

abnormal neuroanatomy | larval stage (with Df(3R)Exel6191)

Nrx-1²⁴¹

abnormal neuroanatomy | larval stage | recessive

Nrx-1²⁷³

abnormal neuroanatomy | pharate adult stage (with Df(3R)Exel6191)

Nrx-1²⁴¹

abnormal neuroanatomy | pupal stage | somatic clone

Nrx-1²⁷³

abnormal neuroanatomy | recessive | third instar larval stage

Nrx-1²⁷³

abnormal neuroanatomy | third instar larval stage (with Df(3R)5C1)

abnormal neurophysiology (with Df(3R)5C1)

Nrx-1²⁷³

abnormal neurophysiology | adult stage

Nrx-1^Δ83

abnormal neurophysiology | embryonic stage, with Scer\GAL4^elav.PLu

Nrx-1^RNAi.UAS

abnormal neurophysiology | embryonic stage (with Df(3R)Exel6191)

Nrx-1³¹³

abnormal neurophysiology | larval stage

abnormal neurophysiology | late third instar larval stage

Nrx-1^Δ83

abnormal neurophysiology | third instar larval stage

Nrx-1²⁷³

abnormal neurophysiology | third instar larval stage (with Nrx-1²⁷³)

Nrx-1^Δ83

abnormal neurophysiology | third instar larval stage (with Nrx-1^Δ83)

Nrx-1²⁷³

abnormal neurophysiology | third instar larval stage | conditional (with Nrx-1²⁷³)

Nrx-1^Δ83

abnormal neurophysiology | third instar larval stage | conditional (with Nrx-1^Δ83)

Nrx-1²⁷³

abnormal phototaxis | adult stage

Nrx-1^Δ83

decreased size | larval stage

decreased size | third instar larval stage (with Df(3R)5C1)

Nrx-1²⁴¹

increased size | larval stage

Nrx-1^AT

increased size | larval stage, with Nrx-1^{PDZ.UAS.NbALFA}, Scer\GAL4^BG380

Nrx-1^ΔPDZ-AT

increased size | larval stage, with Nrx-1^ΔPDZ-AT, Scer\GAL4^BG380

Nrx-1^{PDZ.UAS.NbALFA}

short lived

Nrx-1^Δ83

some die during pupal stage

Nrx-1²⁷³

uncoordinated | larval stage

Nrx-1²⁷³

uncoordinated | larval stage (with Df(3R)5C1)

Nrx-1²⁷³

uncoordinated | larval stage (with Nrx-1²⁴¹)

Nrx-1²⁷³

uncoordinated | larval stage (with Nrx-1²⁷³)

Nrx-1²⁴¹

visible, with Scer\GAL4^GMR.PU

Nrx-1^GD2619

Phenotype manifest in

Allele

abdominal lateral tergosternal muscle cell | pharate adult stage (with Df(3R)Exel6191)

Nrx-1²⁴¹

adult persistent motor neuron | pharate adult stage (with Df(3R)Exel6191)

Nrx-1²⁴¹

axon | adult stage

axon | adult stage, with Scer\GAL4^GMR31C06

Nrx-1^HMS00403

axon | adult stage (with Nrx-1²⁷³)

Nrx-1^Δ83

axon | adult stage (with Nrx-1^Δ83)

Nrx-1²⁷³

axon | adult stage | somatic clone

Nrx-1²⁷³

axon | pupal stage | somatic clone

Nrx-1²⁷³

bouton, with Scer\GAL4^elav-C155

Nrx-1^UAS.cLa

bouton, with Scer\GAL4^futsch-C380

Nrx-1^UAS.cLa

bouton | late third instar larval stage

Nrx-1^Δ83

distal axon | pharate adult stage (with Df(3R)Exel6191)

Nrx-1²⁴¹

embryonic/larval neuromuscular junction | larval stage

embryonic/larval neuromuscular junction | larval stage, with Nrx-1^{PDZ.UAS.NbALFA}, Scer\GAL4^BG380

Nrx-1^ΔPDZ-AT

embryonic/larval neuromuscular junction | larval stage, with Nrx-1^ΔPDZ-AT, Scer\GAL4^BG380

Nrx-1^{PDZ.UAS.NbALFA}

embryonic/larval neuromuscular junction | late third instar larval stage

Nrx-1^Δ83

embryonic/larval neuromuscular junction | third instar larval stage (with Df(3R)5C1)

embryonic/larval neuromuscular junction | third instar larval stage (with Nrx-1²⁷³)

Nrx-1^Δ83

embryonic/larval neuromuscular junction | third instar larval stage (with Nrx-1^Δ83)

Nrx-1²⁷³

embryonic/larval neuromuscular junction | third instar larval stage | conditional (with Nrx-1²⁷³)

Nrx-1^Δ83

embryonic/larval neuromuscular junction | third instar larval stage | conditional (with Nrx-1^Δ83)

Nrx-1²⁷³

eye, with Scer\GAL4^GMR.PU

Nrx-1^GD2619

lamina monopolar neuron L4 | adult stage

lamina monopolar neuron L4 | adult stage, with Scer\GAL4^GMR31C06

Nrx-1^HMS00403

lamina monopolar neuron L4 | adult stage (with Nrx-1²⁷³)

Nrx-1^Δ83

lamina monopolar neuron L4 | adult stage (with Nrx-1^Δ83)

Nrx-1²⁷³

lamina monopolar neuron L4 | adult stage | somatic clone

Nrx-1²⁷³

lamina monopolar neuron L4 | pupal stage | somatic clone

Nrx-1²⁷³

larval brain | larval stage, with Scer\GAL4^elav.PU

Nrx-1^UAS.cZa

medulla | adult stage

medulla | adult stage, with Scer\GAL4^GMR31C06

Nrx-1^HMS00403

medulla | adult stage (with Nrx-1²⁷³)

Nrx-1^Δ83

medulla | adult stage (with Nrx-1^Δ83)

Nrx-1²⁷³

medulla | adult stage | somatic clone

Nrx-1²⁷³

medulla | pupal stage | somatic clone

Nrx-1²⁷³

muscle cell of A1-7 lateral longitudinal muscle 1 | third instar larval stage (with Df(3R)5C1)

Nrx-1²⁴¹

neuromuscular junction (with Df(3R)5C1)

Nrx-1²⁷³

neuromuscular junction | embryonic stage, with Scer\GAL4^elav.PLu

Nrx-1^RNAi.UAS

neuromuscular junction | embryonic stage (with Df(3R)Exel6191)

Nrx-1³¹³

neuromuscular junction | larval stage (with Df(3R)Exel6191)

Nrx-1²⁴¹

neuromuscular junction | third instar larval stage

neuromuscular junction | third instar larval stage, with Scer\GAL4^elav.PU

Nrx-1^UAS.cLa

NMJ bouton | decreased number | larval stage

NMJ bouton | increased number | larval stage

Nrx-1^AT

NMJ bouton | increased number | larval stage, with Nrx-1^20xUAS.cVa, Scer\GAL4^BG380

Nrx-1²⁷³

NMJ bouton | increased number | larval stage, with Nrx-1^{20xUAS.Tag:ALFA}, Scer\GAL4^BG380

Nrx-1²⁷³

NMJ bouton | increased number | larval stage, with Nrx-1²⁷³, Scer\GAL4^BG380

NMJ bouton | increased number | larval stage, with Nrx-1^{PDZ.UAS.NbALFA}, Scer\GAL4^BG380

Nrx-1^ΔPDZ-AT

NMJ bouton | increased number | larval stage, with Nrx-1^UAS.GFP, Scer\GAL4^BG380

Nrx-1²⁷³

NMJ bouton | increased number | larval stage, with Nrx-1^ΔPDZ-AT, Scer\GAL4^BG380

Nrx-1^{PDZ.UAS.NbALFA}

NMJ bouton | larval stage, with Scer\GAL4^elav.PU

Nrx-1^UAS.cZa

NMJ bouton | third instar larval stage

Nrx-1²⁷³

NMJ bouton | third instar larval stage (with Df(3R)5C1)

postsynaptic density

Nrx-1²⁷³

postsynaptic density | third instar larval stage

Nrx-1²⁷³

presynaptic active zone (with Df(3R)5C1)

Nrx-1²⁴¹

presynaptic active zone | decreased number (with Df(3R)5C1)

Nrx-1²⁴¹

presynaptic active zone | increased number

Nrx-1²⁷³

presynaptic active zone | larval stage, with Scer\GAL4^elav.PU

Nrx-1^UAS.cZa

presynaptic active zone | third instar larval stage

subsynaptic reticulum

Nrx-1²⁷³

subsynaptic reticulum | third instar larval stage

Nrx-1²⁷³

synapse

Nrx-1^Δ83

synapse (with Df(3R)Exel6191)

Nrx-1^Δ83

synaptic vesicle

Nrx-1^Δ83

terminal bouton | third instar larval stage

Nrx-1²⁷³

terminal bouton | third instar larval stage, with Scer\GAL4^elav.PU

Nrx-1^UAS.cLa

type I bouton (with Df(3R)5C1)

Nrx-1²⁷³

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (33)

Hsap\NRXN2

13 of 14

Yes

Hsap\NRXN1

12 of 14

Yes

Hsap\NRXN3

12 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\SHBG

1 of 14

Yes

Hsap\SLIT2

1 of 14

Hsap\SLIT3

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (28)

Rnor\Nrxn2

12 of 14

Yes

Rnor\Nrxn3

12 of 14

Yes

Rnor\Nrxn1

11 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Shbg

1 of 14

Yes

Mus musculus (laboratory mouse) (28)

Mmus\Nrxn2

13 of 14

Yes

Mmus\Nrxn3

13 of 14

Yes

Mmus\Nrxn1

12 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Shbg

1 of 14

Yes

Mmus\Slit2

1 of 14

Xenopus tropicalis (Western clawed frog) (22)

Xtro\nrxn3

8 of 13

Yes

Xtro\nrxn1

7 of 13

Yes

Xtro\nrxn2

6 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (36)

Drer\nrxn1a

12 of 14

Yes

Drer\nrxn1b

12 of 14

Yes

Drer\nrxn2a

12 of 14

Yes

Drer\nrxn3a

12 of 14

Yes

Drer\nrxn3b

12 of 14

Yes

Drer\nrxn2b

4 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\shbg

1 of 14

Yes

Drer\si:ch211-241e1.3

1 of 14

Drer\si:dkey-22o22.2

1 of 14

Drer\ush2a

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (12)

Cele\nrx-1

11 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (14)

Agam\AgaP_AGAP004066

12 of 12

Yes

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Nrx-1. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (28)

Nrx-IV

4 of 13

axo

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

crb

1 of 13

Cubn2

1 of 13

Cubn

1 of 13

eys

1 of 13

kon

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

tld

1 of 13

tok

1 of 13

trol

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 5 )

Allele

Disease

Evidence

References

Nrx-1^Δ83

model of autism spectrum disorder

CEA

(Guangming et al., 2023)

CEA with Nlg3^KO127

(Guangming et al., 2023)

Nrx-1^HP35068

model of autism spectrum disorder

CEA

(Dong et al., 2016)

Nrx-1^JF02652

model of autism spectrum disorder

CEA

(Dong et al., 2016)

Nrx-1²⁷³

model of autism spectrum disorder

CEA

(Guangming et al., 2023, Levy et al., 2022, Rui et al., 2017)

CEA with Nrx-1²⁴¹

(Levy et al., 2022)

Nrx-1²⁴¹

model of autism spectrum disorder

CEA

(Levy et al., 2022)

CEA with Nrx-1²⁷³

(Levy et al., 2022)

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

NRXN1; neurexin 1

model of Pitt-Hopkins-like syndrome 2

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 4 )

Allele

Disease

Interaction

References

Nrx-1^Δ83

model of autism spectrum disorder

is exacerbated by Nlg4^KO10

(Guangming et al., 2023)

is ameliorated by Nrx-1^Δ174

(Guangming et al., 2023)

Nrx-1^Δ174

ameliorates autism spectrum disorder

modeled by Nrx-1^Δ83

(Guangming et al., 2023)

Nrx-1²⁷³

model of autism spectrum disorder

is ameliorated by scrib^UAS.GFP

(Rui et al., 2017)

Nrx-1^MI02579

ameliorates Huntington's disease

modeled by Hsap\HTT^{128Q.1-231.UAS}

(Onur et al., 2021)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

13 of 14

12 of 14

Pitt-Hopkins-like syndrome 2

NRXN3; neurexin 3

12 of 14

600567

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

RNA-protein

Physical Interaction

Assay

References

Nrx-1 - Syp

anti bait coimmunoprecipitation, quantitative reverse transcription pcr

(McDermott et al., 2014)

protein-protein

Physical Interaction

Assay

References

Nrx-1 - CASK

two hybrid, anti bait coimmunoprecipitation, western blot, pull down

(Sun et al., 2009)

Nrx-1 - Dg

anti tag coimmunoprecipitation, anti tag western blot

(Zhao et al., 2024)

Nrx-1 - Ephrin

pull down, molecular weight estimation by staining, anti bait coimmunoprecipitation, western blot, two hybrid

(Liu et al., 2017)

Nrx-1 - Megf8

anti bait coimmunoprecipitation, western blot

(Chen et al., 2022)

Nrx-1 - Nlg1

anti bait coimmunoprecipitation, western blot

(Banerjee et al., 2017)

Nrx-1 - Nlg2

anti bait coimmunoprecipitation, western blot

(Chen et al., 2012, Sun et al., 2011)

Nrx-1 - RhoGAP100F

isothermal titration calorimetry, predetermined participant, two hybrid, anti bait coimmunoprecipitation, western blot

(Muhammad et al., 2015, Owald et al., 2012)

Nrx-1 - Spn

anti bait coimmunoprecipitation, western blot, pull down, molecular weight estimation by staining, two hybrid, isothermal titration calorimetry, predetermined participant, x-ray crystallography

(Muhammad et al., 2015)

Nrx-1 - apolpp

anti bait coimmunoprecipitation, western blot, two hybrid, pull down

(Tian et al., 2013)

Nrx-1 - comt

pull down, western blot, anti bait coimmunoprecipitation, two hybrid

(Li et al., 2015)

Nrx-1 - rt

anti tag coimmunoprecipitation, anti tag western blot

(Zhao et al., 2024)

Nrx-1 - scrib

anti tag coimmunoprecipitation, western blot, pull down

(Rui et al., 2017)

Nrx-1 - tw

anti tag coimmunoprecipitation, anti tag western blot

(Zhao et al., 2024)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Sun et al., 2009)

enhanceable

(Sun et al., 2011)

enhanceable

(Banerjee et al., 2017)

Nrx-1

suppressible

wit

(Banerjee et al., 2017)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Sun et al., 2009)

suppressible

(Mozer and Sandstrom, 2012, Owald et al., 2012)

enhanceable

(Sun et al., 2011)

suppressible

(Ramesh et al., 2021)

Syx4

enhanceable

Nrx-1

(Harris et al., 2016)

External Data

Subunit Structure (UniProtKB)

(UniProt, Q3KN41 )

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0038975

MIST (genetic) - An integrated Molecular Interaction Database

42646

MIST (protein-protein) - An integrated Molecular Interaction Database

42646

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Neurexins and neuroligins

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-75

Cytogenetic map

94A16-94B1

Sequence location

3R:22,468,512..22,486,969 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

94A16-94B1

Limits computationally determined from genome sequence between P{PZ}l(3)rQ178^rQ178 and P{lacW}Dph5^L4910

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-75

(FlyBase, 2016)

3-77.4

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (17)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

72337

w¹¹¹⁸; P{VT045774-p65.AD}attP40

19299

w¹¹¹⁸; P{XP}Nrx-1^d08766

71965

w¹¹¹⁸; P{VT045774-GAL4.DBD}attP2

21977

w¹¹¹⁸; P{EPg}Nrx-1^HP35068

27502

y¹ v¹; P{TRiP.JF02652}attP2

61696

y¹ w^*; Mi{MIC}Nrx-1^MI02579

Korea

12498

P{VT045774-GAL4}attP2

14645

P{VT045774-lexA}attP2

11100

P{EP}Nrx-1^G9024

VDRC

v4306

w¹¹¹⁸; P{GD2619}v4306

v36328

w¹¹¹⁸; P{GD14451}v36328

v36326

w¹¹¹⁸; P{GD14451}v36326/TM3

More stocks available...

Genomic Clones (29)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (13)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0038975

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0038975

Antibody Information

Laboratory Generated Antibodies

monoclonal

(Liu et al., 2017, Sun et al., 2009)

polyclonal

(Tong et al., 2016, Tian et al., 2013, Chen et al., 2010, Li et al., 2007, Zeng et al., 2007)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Loss of Nrx-1 leads to defects in rhodopsin maturation, as a consequence of a reduction in chromophore levels. Neurexin interacts with apolipoprotein I (ApoLI) and is required for the appropriate level of ApoLI and ApoLII proteins.

(Tian et al., 2013)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Nrx-1 CG7050

(Auld, 2001.3.7)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (23)

Reported As

Symbol Synonym

CG7050

(Kim et al., 2021, Aradska et al., 2015, Hosono et al., 2015, Li et al., 2015, Tian et al., 2013, Khanna et al., 2010, Ni et al., 2010.12.1, Perkins et al., 2009, Zweier et al., 2009, Zeng et al., 2007, Arbeitman et al., 2004, Furlong et al., 2001)

CT21808

(Hynes and Zhao, 2000)

DNrx

(Xing et al., 2018, Blunk et al., 2014, Xing et al., 2014)

Dnrx

(Zhang et al., 2018)

Nrx

(Turrel et al., 2024, Waddell et al., 2019, Constance et al., 2018, Fan et al., 2013, Fan et al., 2013, Mack et al., 2006, Wang et al., 2006, Lee et al., 2003)

Nrx-1

(Iwanaga et al., 2024, Vicidomini et al., 2024, Corthals et al., 2023, Garcia-Vaquero et al., 2023, Voutyraki et al., 2023, Levy et al., 2022, Pizzo et al., 2021, Salim et al., 2021, Szikora et al., 2021, Kurmangaliyev et al., 2020, Mariano et al., 2020, Singh et al., 2020, Watanabe et al., 2020, Spinner et al., 2018, Transgenic RNAi Project members, 2017-, David-Morrison et al., 2016, Dong et al., 2016, Gene Disruption Project members, 2016-, Harris et al., 2016, Shen et al., 2016, Aradska et al., 2015, Harris and Littleton, 2015, Muhammad et al., 2015, Ashwal-Fluss et al., 2014, Sen et al., 2013, Zhang et al., 2013, Owald et al., 2012, Owald et al., 2012, Williams et al., 2012, Winbush et al., 2012, Haussmann et al., 2011, Zweier et al., 2009, Zhou et al., 2008, Geng and MacDonald, 2007, Zeng et al., 2007)

Nrx-I

(Zweier et al., 2009)

Nrx1

(Baranski et al., 2018, Huang et al., 2017, Adolfsen et al., 2004)

dNRXN3

(Onur et al., 2021)

dNrx

(Liu et al., 2017)

dnrx

(Guangming et al., 2023, Chen et al., 2022, Wu et al., 2018, Xing et al., 2018, Banerjee et al., 2017, Rui et al., 2017, Sun et al., 2016, Chen et al., 2012, Owald et al., 2012, Sun et al., 2011, Banovic et al., 2010, Sun et al., 2009, Li et al., 2007)

dnrx-1

(Salinas et al., 2001)

dnrx1

(Pandey et al., 2017, Mozer and Sandstrom, 2012)

neurexin

(Coutinho-Budd et al., 2024, Barber et al., 2021, Kamimura and Maeda, 2021)

nrx

(Bedont et al., 2021, Guangming et al., 2020, Sulkowski et al., 2016, Tong et al., 2016, Li et al., 2015, Blunk et al., 2014, Tian et al., 2013, Chen et al., 2010)

nrx-1

(Lim-Kian-Siang et al., 2024, Smith et al., 2024, Onur et al., 2021, Hoover et al., 2019, Meltzer et al., 2019, D'Rozario et al., 2016, McDermott et al., 2014)

nrx1

(Gunderson et al., 2021, Chou et al., 2020, Iyer et al., 2016)

Name Synonyms

Drosophila neurexin

(Li et al., 2007)

Neurexin

(Chakraborty et al., 2020, Finegan and Bergstralh, 2020, Mukherjee et al., 2014, Choi et al., 2011, Sun et al., 2011, Banovic et al., 2010, Zeng et al., 2007)

Neurexin 1

(Khanna et al., 2010, Khanna et al., 2010, Zeng et al., 2007, Salinas et al., 2001)

Neurexin-1

(Dong et al., 2016, Winbush et al., 2012, Zeng et al., 2007)

Neurexin-like

(Hynes and Zhao, 2000)

neurexin

(Shafer and Keene, 2021, D'Rozario et al., 2016, Blunk et al., 2014, Tian et al., 2013, Owald et al., 2012, Chen et al., 2010, Sun et al., 2009, Li et al., 2007)

neurexin 1

(Ni, 2021, Mozer and Sandstrom, 2012)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 69 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

42646

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q3KN41

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q3KN41

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q3KN41

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42646/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0038975

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0038975

FlyMine - An integrated database for Drosophila genomics

FBgn0038975

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG7050

MARRVEL_MODEL - MARRVEL (model organism gene)

42646

PDB - An information portal to biological macromolecular structures

4XHV

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0038975

DroID - A comprehensive database of gene and protein interactions.

FBgn0038975

DRSC - Results frm RNAi screens

FBgn0038975

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0038975

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0038975

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7050

Flygut - An atlas of the Drosophila adult midgut

FBgn0038975

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC034774

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (genetic) - An integrated Molecular Interaction Database

42646

MIST (protein-protein) - An integrated Molecular Interaction Database

42646

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Neurexins and neuroligins

References (154)

The following external sites may use different assemblies or annotations than FlyBase.

-0.69

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