• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\Nrx-1

General Information
Symbol	Dmel\Nrx-1	Species	D. melanogaster
Name	Neurexin 1	Annotation symbol	CG7050
Feature type	protein_coding_gene	FlyBase ID	FBgn0038975
Gene Model Status	Current	Stock availability	10 publicly available
Also Known As	Nrx, dnrx
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	94A16-94B1	Sequence location	3R:18,294,258..18,312,401 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Neurexin 1 is referred to in FlyBase by the symbol Dmel\Nrx-1 (CG7050, FBgn0038975). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: synapse assembly; synaptic transmission; associative learning; synapse organization. 21 alleles are reported. The phenotypes of these alleles are annotated with: bouton; neuromuscular junction; type I bouton; synapse. It has 8 annotated transcripts and 8 annotated polypeptides. Protein features are: Concanavalin A-like lectin/glucanase, subgroup; Concanavalin A-like lectin/glucanases superfamily; Epidermal growth factor-like domain; Laminin G domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed within 12-24 hour embryonic stages, during early larval stages, at stages throughout the pupal period, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval central nervous system. Comments on Affy2 ProbeSet: ProbeSet 1625623_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Nrx-1. Gene sequence location is 3R:18294258..18312401.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03	Alleles Nrx-1[Scer\UAS.cTa] Nrx-1[DeltaN.Scer\UAS] Nrx-1[DeltaC.Scer\UAS] Controlled Vocabulary Terms apolipoprotein binding vitamin A transport Transgenic Constructs P{UAS-Nrx-1.DeltaC} P{UAS-Nrx-1.T} P{UAS-Nrx-1.DeltaN}
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 94A16-94B1   Limits computationally determined from genome sequence between P{PZ}l(3)rQ178rQ178 and P{lacW}Dph5L4910
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Nrx-1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47 Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated Low-frequency RNA-Seq exon junction(s) not annotated. Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters. DGC clone LP03809 appears problematic: incomplete CDS
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Nrx-1-RA FBtr0084256  NM_079725   6257   1837 Nrx-1-RB FBtr0301485  NM_001170216   6266   1840 Nrx-1-RC FBtr0334607  NM_001275908   6612   1837 Nrx-1-RD FBtr0334608  NM_001275909   6621   1840 Nrx-1-RE FBtr0334609  NM_001275910   6576   1825 Nrx-1-RF FBtr0334610  NM_001275911   6642   1847 Nrx-1-RG FBtr0334611  NM_001275912   6147   1525 Nrx-1-RH FBtr0334612  NM_001275913   9346   1840
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Nrx-1-PA   FBpp0083649   199.3   1837   7.15     NP_524449   AAF56006 Nrx-1-PB   FBpp0290700   199.6   1840   7.15     NP_001163687   ACZ94983 Nrx-1-PC   FBpp0306674   199.3   1837   7.15     NP_001262837   AGB96217 Nrx-1-PD   FBpp0306675   199.6   1840   7.15     NP_001262838   AGB96218 Nrx-1-PE   FBpp0306676   197.9   1825   7.15     NP_001262839   AGB96219 Nrx-1-PF   FBpp0306677   200.4   1847   7.20     NP_001262840   AGB96220 Nrx-1-PG   FBpp0306678   167.4   1525   6.96     NP_001262841   AGB96221 Nrx-1-PH   FBpp0306679   199.6   1840   7.15     NP_001262842   AGB96222
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Epidermal growth factor-like domain (IPR000742) Laminin G domain (IPR001791) Concanavalin A-like lectin/glucanases superfamily (IPR008985) Concanavalin A-like lectin/glucanase, subgroup (IPR013320)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA567526   AA697990   AE014297 AAF56006   AE014297 ACZ94983   AE014297 AGB96217   AE014297 AGB96218   AE014297 AGB96219   AE014297 AGB96220   AE014297 AGB96221   AE014297 AGB96222   AI108014   AI109124   AI239060   AI260118   AI388381   AI402031   AW940146   AW944025   AY069731 AAL39876   BT023898   CO271064   CO293121   CO295981   CO303446   CO308930   CO333157   CO340063   CZ468744   EC071540   EC075666   EC076903   EC077754   EC213312   EC214460   EC226058   EC227368   EC231849   EC237450   EC239829   EC253629
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VCZ9 Q3KN41 Q8SZX4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
expression microarray Stage Tissue/Position (including subcellular localization) Reference adult stage | male     (Arbeitman et al., 2004) in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 14 -- 15   presumptive embryonic/larval central nervous system   (Li et al., 2007) embryonic stage 14 -- 17   ventral nerve cord   (Li et al., 2007) embryonic stage 16 -- 17   embryonic/larval brain   (Li et al., 2007) embryonic/larval central nervous system   (Li et al., 2007) embryonic/larval peripheral nervous system   (Li et al., 2007)
Additional Descriptive Data
	Nrx-1 transcripts are enriched in brain and ventral nerve cord neurons starting at embryonic stage 14 and are absent from muscle. They are also detected in small subsets of peripheral nervous system neurons. (Li et al., 2007)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 14 -- 15   presumptive embryonic/larval central nervous system   (Li et al., 2007) embryonic stage 16 -- 17   embryonic/larval brain   (Li et al., 2007) ventral nerve cord   (Li et al., 2007) embryonic/larval central nervous system   (Li et al., 2007) neuron   • axon (Li et al., 2007) third instar larval stage   embryonic/larval neuromuscular junction   (Li et al., 2007) embryonic/larval hypodermal muscle   • neuromuscular junction (Li et al., 2007) NMJ bouton   (Li et al., 2007) type I bouton   (Li et al., 2007) neuron   • type I terminal bouton (Li et al., 2007) adult stage   adult brain   (Tian et al., 2013) retina   (Tian et al., 2013) rhabdomere of eye photoreceptor cell   (Tian et al., 2013) western blot Stage Tissue/Position (including subcellular localization) Reference adult stage   adult head   (Tian et al., 2013) retina   (Tian et al., 2013)
Additional Descriptive Data
	Nrx-1 protein is observed in the brain and ventral nerve cord starting at embryonic stage 14 and in third instar larvae. It is localized in the CNS neuropil and axonal tracts and motor axons. It is found in type I boutons of the larval body wall muscles. Nrx-1 protein is concentrated at active zones in neuromuscular junctions but also extends into periactive zones. (Li et al., 2007)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
neuromuscular junction inferred from direct assay (Chen et al., 2010) plasma membrane inferred from direct assay (Khanna et al., 2010)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval central nervous system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    203.675 Larval Midgut    14.3 Larval Hindgut    24.8 Larval Malpighian Tubules    7 Larval Fat Body    8.3 Larval Salivary Gland    5.4 Larval Trachea    5.75 Larval Carcass    8.25 Adult Head    156.7 Adult Eye    88.175 Adult Brain    844.5 Adult Thoracic-Abdominal Ganglion    693.8 Adult Crop    98.1 Adult Midgut    20.7 Adult Hindgut    41.2 Adult Malpighian Tubules    7.4 Adult Fat Body    16.5 Adult Salivary Gland    17.2 Adult Heart    76.575 Adult VirginFemale Spermatheca    14.7 Adult InseminatedFemale Spermatheca    13.2 Adult Ovary    2 Adult Testis    6.5 Adult Male Accessory Gland    40.4 Adult Carcass    27.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    203.675 Larval Midgut    14.3 Larval Hindgut    24.8 Larval Malpighian Tubules    7 Larval Fat Body    8.3 Larval Salivary Gland    5.4 Larval Trachea    5.75 Larval Carcass    8.25 Adult Head    156.7 Adult Eye    88.175 Adult Brain  (844.5) Adult Thoracic-Abdominal Ganglion  (693.8) Adult Crop    98.1 Adult Midgut    20.7 Adult Hindgut    41.2 Adult Malpighian Tubules    7.4 Adult Fat Body    16.5 Adult Salivary Gland    17.2 Adult Heart    76.575 Adult VirginFemale Spermatheca    14.7 Adult InseminatedFemale Spermatheca    13.2 Adult Ovary    2 Adult Testis    6.5 Adult Male Accessory Gland    40.4 Adult Carcass    27.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    203.675 Larval Midgut    14.3 Larval Hindgut    24.8 Larval Malpighian Tubules    7 Larval Fat Body    8.3 Larval Salivary Gland    5.4 Larval Trachea    5.75 Larval Carcass    8.25 Adult Head    156.7 Adult Eye    88.175 Adult Brain    844.5 Adult Thoracic-Abdominal Ganglion    693.8 Adult Crop    98.1 Adult Midgut    20.7 Adult Hindgut    41.2 Adult Malpighian Tubules    7.4 Adult Fat Body    16.5 Adult Salivary Gland    17.2 Adult Heart    76.575 Adult VirginFemale Spermatheca    14.7 Adult InseminatedFemale Spermatheca    13.2 Adult Ovary    2 Adult Testis    6.5 Adult Male Accessory Gland    40.4 Adult Carcass    27.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    203.675 Larval Midgut    14.3 Larval Hindgut    24.8 Larval Malpighian Tubules    7 Larval Fat Body    8.3 Larval Salivary Gland    5.4 Larval Trachea    5.75 Larval Carcass    8.25 Adult Head    156.7 Adult Eye    88.175 Adult Brain    844.5 Adult Thoracic-Abdominal Ganglion    693.8 Adult Crop    98.1 Adult Midgut    20.7 Adult Hindgut    41.2 Adult Malpighian Tubules    7.4 Adult Fat Body    16.5 Adult Salivary Gland    17.2 Adult Heart    76.575 Adult VirginFemale Spermatheca    14.7 Adult InseminatedFemale Spermatheca    13.2 Adult Ovary    2 Adult Testis    6.5 Adult Male Accessory Gland    40.4 Adult Carcass    27.8 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    203.675 Larval Midgut    14.3 Larval Hindgut    24.8 Larval Malpighian Tubules    7 Larval Fat Body    8.3 Larval Salivary Gland    5.4 Larval Trachea    5.75 Larval Carcass    8.25 Adult Head    156.7 Adult Eye    88.175 Adult Brain    844.5 Adult Thoracic-Abdominal Ganglion    693.8 Adult Crop    98.1 Adult Midgut    20.7 Adult Hindgut    41.2 Adult Malpighian Tubules    7.4 Adult Fat Body    16.5 Adult Salivary Gland    17.2 Adult Heart    76.575 Adult VirginFemale Spermatheca    14.7 Adult InseminatedFemale Spermatheca    13.2 Adult Ovary    2 Adult Testis    6.5 Adult Male Accessory Gland    40.4 Adult Carcass    27.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    203.675 Larval Midgut    14.3 Larval Hindgut    24.8 Larval Malpighian Tubules    7 Larval Fat Body    8.3 Larval Salivary Gland    5.4 Larval Trachea    5.75 Larval Carcass    8.25 Adult Head    156.7 Adult Eye    88.175 Adult Brain  (844.5) Adult Thoracic-Abdominal Ganglion  693.8 Adult Crop    98.1 Adult Midgut    20.7 Adult Hindgut    41.2 Adult Malpighian Tubules    7.4 Adult Fat Body    16.5 Adult Salivary Gland    17.2 Adult Heart    76.575 Adult VirginFemale Spermatheca    14.7 Adult InseminatedFemale Spermatheca    13.2 Adult Ovary    2 Adult Testis    6.5 Adult Male Accessory Gland    40.4 Adult Carcass    27.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    203.675 Larval Midgut    14.3 Larval Hindgut    24.8 Larval Malpighian Tubules    7 Larval Fat Body    8.3 Larval Salivary Gland    5.4 Larval Trachea    5.75 Larval Carcass    8.25 Adult Head    156.7 Adult Eye    88.175 Adult Brain    844.5 Adult Thoracic-Abdominal Ganglion    693.8 Adult Crop    98.1 Adult Midgut    20.7 Adult Hindgut    41.2 Adult Malpighian Tubules    7.4 Adult Fat Body    16.5 Adult Salivary Gland    17.2 Adult Heart    76.575 Adult VirginFemale Spermatheca    14.7 Adult InseminatedFemale Spermatheca    13.2 Adult Ovary    2 Adult Testis    6.5 Adult Male Accessory Gland    40.4 Adult Carcass    27.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    203.675 Larval Midgut    14.3 Larval Hindgut    24.8 Larval Malpighian Tubules    7 Larval Fat Body    8.3 Larval Salivary Gland    5.4 Larval Trachea    5.75 Larval Carcass    8.25 Adult Head    156.7 Adult Eye    88.175 Adult Brain    844.5 Adult Thoracic-Abdominal Ganglion    693.8 Adult Crop    98.1 Adult Midgut    20.7 Adult Hindgut    41.2 Adult Malpighian Tubules    7.4 Adult Fat Body    16.5 Adult Salivary Gland    17.2 Adult Heart    76.575 Adult VirginFemale Spermatheca    14.7 Adult InseminatedFemale Spermatheca    13.2 Adult Ovary    2 Adult Testis    6.5 Adult Male Accessory Gland    40.4 Adult Carcass    27.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    156.7   NA  Eye    88.175   NA  Brain    844.5   203.675  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    693.8   NA  Crop    98.1   no informative data  Midgut    no informative data   24.8  Hindgut    41.2   7  Malpighian Tubules    7.4   8.3  Fat Body    no informative data   5.4  Salivary Gland    no informative data   NA  Heart    76.575   5.75  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    2   NA  Testis    6.5   NA  Male Accessory Gland    40.4   8.25  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    22 central nervous system, pupae P8    121 head, virgin 1-day female    43 head, virgin 4-day female    43 head, virgin 20-day female    25 head, mated 1-day female    40 head, mated 4-day female    37 head, mated 20-day female    22 head, mated 1-day male    66 head, mated 4-day male    69 head, mated 20-day male    59 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    9 carcass, larvae L3 wandering    3 carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    22 central nervous system, pupae P8  (121) head, virgin 1-day female  (43) head, virgin 4-day female  (43) head, virgin 20-day female    25 head, mated 1-day female  (40) head, mated 4-day female  (37) head, mated 20-day female    22 head, mated 1-day male  (66) head, mated 4-day male  (69) head, mated 20-day male  (59) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    9 carcass, larvae L3 wandering    3 carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    22 central nervous system, pupae P8  (121) head, virgin 1-day female    43 head, virgin 4-day female    43 head, virgin 20-day female    25 head, mated 1-day female    40 head, mated 4-day female    37 head, mated 20-day female    22 head, mated 1-day male    66 head, mated 4-day male    69 head, mated 20-day male    59 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    9 carcass, larvae L3 wandering    3 carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    22 central nervous system, pupae P8    121 head, virgin 1-day female    43 head, virgin 4-day female    43 head, virgin 20-day female    25 head, mated 1-day female    40 head, mated 4-day female    37 head, mated 20-day female    22 head, mated 1-day male    66 head, mated 4-day male    69 head, mated 20-day male    59 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    9 carcass, larvae L3 wandering    3 carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    22 central nervous system, pupae P8    121 head, virgin 1-day female    43 head, virgin 4-day female    43 head, virgin 20-day female    25 head, mated 1-day female    40 head, mated 4-day female    37 head, mated 20-day female    22 head, mated 1-day male    66 head, mated 4-day male    69 head, mated 20-day male    59 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    9 carcass, larvae L3 wandering    3 carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    22 central nervous system, pupae P8  (121) head, virgin 1-day female  (43) head, virgin 4-day female  (43) head, virgin 20-day female    25 head, mated 1-day female  (40) head, mated 4-day female  (37) head, mated 20-day female    22 head, mated 1-day male  (66) head, mated 4-day male  (69) head, mated 20-day male  (59) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    9 carcass, larvae L3 wandering    3 carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    22 central nervous system, pupae P8  121 head, virgin 1-day female    43 head, virgin 4-day female    43 head, virgin 20-day female    25 head, mated 1-day female    40 head, mated 4-day female    37 head, mated 20-day female    22 head, mated 1-day male    66 head, mated 4-day male    69 head, mated 20-day male    59 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    9 carcass, larvae L3 wandering    3 carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    22 central nervous system, pupae P8    121 head, virgin 1-day female    43 head, virgin 4-day female    43 head, virgin 20-day female    25 head, mated 1-day female    40 head, mated 4-day female    37 head, mated 20-day female    22 head, mated 1-day male    66 head, mated 4-day male    69 head, mated 20-day male    59 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    9 carcass, larvae L3 wandering    3 carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed within 12-24 hour embryonic stages, during early larval stages, at stages throughout the pupal period, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    2 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    2 embryo 12-14hr    5 embryo 14-16hr    16 embryo 16-18hr    19 embryo 18-20hr    18 embryo 20-22hr    15 embryo 22-24hr    15 larva L1    18 larva L2    6 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    4 white prepupae new    4 white prepupae 12hr    9 white prepupae 24hr    16 pupae 2d postWPP    20 pupae 3d postWPP    18 pupae 4d postWPP    20 adult male 01day    21 adult male 05day    28 adult male 30day    30 adult female 01day    6 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    2 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    2 embryo 12-14hr    5 embryo 14-16hr    16 embryo 16-18hr    19 embryo 18-20hr    18 embryo 20-22hr    15 embryo 22-24hr    15 larva L1    18 larva L2    6 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    4 white prepupae new    4 white prepupae 12hr    9 white prepupae 24hr    16 pupae 2d postWPP    20 pupae 3d postWPP    18 pupae 4d postWPP    20 adult male 01day    21 adult male 05day  (28) adult male 30day  (30) adult female 01day    6 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    2 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    2 embryo 12-14hr    5 embryo 14-16hr    16 embryo 16-18hr    19 embryo 18-20hr    18 embryo 20-22hr    15 embryo 22-24hr    15 larva L1    18 larva L2    6 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    4 white prepupae new    4 white prepupae 12hr    9 white prepupae 24hr    16 pupae 2d postWPP    20 pupae 3d postWPP    18 pupae 4d postWPP    20 adult male 01day    21 adult male 05day    28 adult male 30day    30 adult female 01day    6 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    2 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    2 embryo 12-14hr    5 embryo 14-16hr    16 embryo 16-18hr    19 embryo 18-20hr    18 embryo 20-22hr    15 embryo 22-24hr    15 larva L1    18 larva L2    6 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    4 white prepupae new    4 white prepupae 12hr    9 white prepupae 24hr    16 pupae 2d postWPP    20 pupae 3d postWPP    18 pupae 4d postWPP    20 adult male 01day    21 adult male 05day    28 adult male 30day    30 adult female 01day    6 adult female 05day    2 adult female 30day    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    2 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    2 embryo 12-14hr    5 embryo 14-16hr    16 embryo 16-18hr    19 embryo 18-20hr    18 embryo 20-22hr    15 embryo 22-24hr    15 larva L1    18 larva L2    6 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    4 white prepupae new    4 white prepupae 12hr    9 white prepupae 24hr    16 pupae 2d postWPP    20 pupae 3d postWPP    18 pupae 4d postWPP    20 adult male 01day    21 adult male 05day    28 adult male 30day    30 adult female 01day    6 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    2 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    2 embryo 12-14hr    5 embryo 14-16hr    16 embryo 16-18hr    19 embryo 18-20hr    18 embryo 20-22hr    15 embryo 22-24hr    15 larva L1    18 larva L2    6 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    4 white prepupae new    4 white prepupae 12hr    9 white prepupae 24hr    16 pupae 2d postWPP    20 pupae 3d postWPP    18 pupae 4d postWPP    20 adult male 01day    21 adult male 05day  28 adult male 30day  30 adult female 01day    6 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    2 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    2 embryo 12-14hr    5 embryo 14-16hr    16 embryo 16-18hr    19 embryo 18-20hr    18 embryo 20-22hr    15 embryo 22-24hr    15 larva L1    18 larva L2    6 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    4 white prepupae new    4 white prepupae 12hr    9 white prepupae 24hr    16 pupae 2d postWPP    20 pupae 3d postWPP    18 pupae 4d postWPP    20 adult male 01day    21 adult male 05day    28 adult male 30day    30 adult female 01day    6 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    2 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    2 embryo 12-14hr    5 embryo 14-16hr    16 embryo 16-18hr    19 embryo 18-20hr    18 embryo 20-22hr    15 embryo 22-24hr    15 larva L1    18 larva L2    6 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    4 white prepupae new    4 white prepupae 12hr    9 white prepupae 24hr    16 pupae 2d postWPP    20 pupae 3d postWPP    18 pupae 4d postWPP    20 adult male 01day    21 adult male 05day    28 adult male 30day    30 adult female 01day    6 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    25 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    15 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    25 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    15 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    25 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    15 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    25 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    15 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    25 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    15 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    25 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    15 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    25 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    15 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    25 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    15 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    10 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    10 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    10 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    10 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    10 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    10 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    10 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    10 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_14 mE1_20_mRNA_expression_cluster_14
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0038975 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7050-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele partially lethal - majority die | pupal stage Nrx-1273 viable Nrx-1d08766 Nrx-1Δ80 Nrx-1Δ83 Nrx-1Δ174 Nrx-1Δ188 viable, with Scer\GAL4pnr-MD237 Nrx-1GD2619 Nrx-1GD14451 viable (with Df(3R)Exel6191) Nrx-1Δ83 Sterility Allele fertile Nrx-1d08766 Nrx-1Δ80 Nrx-1Δ83 Nrx-1Δ174 Nrx-1Δ188 fertile (with Df(3R)Exel6191) Nrx-1Δ83 Other Phenotypes Allele learning defective Nrx-1Δ83 neuroanatomy defective, with Scer\GAL4elav-C155 Nrx-1Scer\UAS.cLa neuroanatomy defective, with Scer\GAL4futsch-C380 Nrx-1Scer\UAS.cLa neuroanatomy defective (with Df(3R)5C1) Nrx-1273 neuroanatomy defective | embryonic stage, with Scer\GAL4elav.PLu Nrx-1dsRNA.Scer\UAS neuroanatomy defective | embryonic stage (with Df(3R)Exel6191) Nrx-1313 neuroanatomy defective | larval stage (with Df(3R)Exel6191) Nrx-1241 neurophysiology defective (with Df(3R)5C1) Nrx-1273 neurophysiology defective | adult stage Nrx-1Δ83 neurophysiology defective | embryonic stage, with Scer\GAL4elav.PLu Nrx-1dsRNA.Scer\UAS neurophysiology defective | embryonic stage (with Df(3R)Exel6191) Nrx-1313 phototaxis defective | adult stage Nrx-1Δ83 short lived Nrx-1Δ83 short lived (with Nrx-1Scer\UAS.cZa), with Scer\GAL4elav-C155 Nrx-1Δ83 short lived (with Nrx-1Δ83), with Scer\GAL4elav-C155 Nrx-1Scer\UAS.cZa uncoordinated | larval stage Nrx-1273 uncoordinated | larval stage (with Df(3R)5C1) Nrx-1273 uncoordinated | larval stage (with Nrx-1241) Nrx-1273 uncoordinated | larval stage (with Nrx-1273) Nrx-1241 Phenotype manifest in Allele bouton, with Scer\GAL4elav-C155 Nrx-1Scer\UAS.cLa bouton, with Scer\GAL4futsch-C380 Nrx-1Scer\UAS.cLa neuromuscular junction (with Df(3R)5C1) Nrx-1273 neuromuscular junction | embryonic stage, with Scer\GAL4elav.PLu Nrx-1dsRNA.Scer\UAS neuromuscular junction | embryonic stage (with Df(3R)Exel6191) Nrx-1313 neuromuscular junction | larval stage (with Df(3R)Exel6191) Nrx-1241 synapse Nrx-1Δ83 synapse (with Df(3R)Exel6191) Nrx-1Δ83 type I bouton (with Df(3R)5C1) Nrx-1273
Classical Alleles ( 11 )
For All Classical Alleles Show
Allele of Nrx-1 Class Mutagen Stocks Known lesion Nrx-1d08766 P-element activity 2 Yes Nrx-1c03581 piggyBac transposase 1 -- Nrx-1HP35068 1 -- Nrx-1MB00002 1 -- Nrx-1241 P-element activity 0 Yes Nrx-1273 P-element activity 0 Yes Nrx-1313 transposable element activity 0 Yes Nrx-1Δ174 Delta2-3 0 Yes Nrx-1Δ188 Delta2-3 0 Yes Nrx-1Δ80 Delta2-3 0 Yes Nrx-1Δ83 Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Nrx-1 Class Mutagen Stocks Known lesion Nrx-1GD14451 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Nrx-1GD2619 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Nrx-1HMS00403 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Nrx-1JF02652 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Nrx-1dsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes Nrx-1GD123 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Nrx-1Scer\UAS.cLa in vitro construct - regulatory fusion 0 Yes Nrx-1Scer\UAS.cTa in vitro construct - regulatory fusion 0 Yes Nrx-1Scer\UAS.cZa in vitro construct - regulatory fusion 0 Yes Nrx-1Scer\UAS.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Nrx-1Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Nrx-1ΔC.Scer\UAS in vitro construct - regulatory fusion 0 Yes Nrx-1ΔN.Scer\UAS in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)5C1 (Li et al., 2007) Df(3R)Exel6191 (Ryder, 2004.4.26, Chen et al., 2010)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD123} NA P{GD2619} NA P{GD14451} NA P{TRiP.HMS00403} NA P{TRiP.JF02652} NA P{UAS-Nrx-1.fl} NA P{UAS-Nrx-1.L} NA P{UAS-Nrx-1.T} NA P{UAS-Nrx-1.ΔC} NA P{UAS-Nrx-1.ΔN} NA P{UAS-Nrx.EGFP} NA P{UAS-nrx.GFP} NA P{UAS-nrx.RNAi} NA GAL4 construct P{Nrx-1-GAL4.T} No
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{PB}Nrx-1c03581 NA insertion of mobile activating element P{EPg}Nrx-1HP35068 NA P{XP}Nrx-1d08766 NA insertion of enhancer trap binary system Mi{ET1}Nrx-1MB00002 No
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 8 terms )
Molecular Function
CV term Evidence References
apolipoprotein binding inferred from physical interaction with Rfabg (Tian et al., 2013)
Biological Process
CV term Evidence References
associative learning inferred from direct assay (Zeng et al., 2007) synapse assembly inferred from direct assay (Zeng et al., 2007) synapse organization inferred from direct assay (Li et al., 2007) synaptic transmission inferred from direct assay (Li et al., 2007) vitamin A transport inferred from mutant phenotype (Tian et al., 2013)
Cellular Component
CV term Evidence References
neuromuscular junction inferred from direct assay (Chen et al., 2010) plasma membrane inferred from direct assay (Khanna et al., 2010)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
plasma membrane non-traceable author statement (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Nrx-1 - Rtnl1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nrx-1 - neuroligin anti bait coimmunoprecipitation, western blot (Sun et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Nrx-1 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0038975 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42646
Orthologs
OrthoDB Orthologs (61) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG637S05 Dipteran inclusive ortholog search EOG6W3SVW Insect inclusive ortholog search EOG6D51SK Arthropod inclusive ortholog search EOG689329 Metazoa inclusive ortholog search EOG6XWTQD
Orthologs in Drosophila Species (EOG637S05)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Nrx-1     Drosophila simulans   Dsim\GD20957 Y   Drosophila sechellia   Dsec\GM26438 Y   Drosophila erecta   Dere\GG11140 Y   Drosophila yakuba   Dyak\GE10306 Y   Drosophila ananassae   Dana\GF23380 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA20059 Y   Drosophila persimilis   Dper\GL24221 Y   Drosophila willistoni   Dwil\GK11702 Y   Drosophila virilis   Dvir\GJ14339 Y   Drosophila mojavensis   Dmoj\GI21979 Y   Drosophila grimshawi   Dgri\GH22245 Y
Orthologs in non-Drosophila Dipterans (EOG6W3SVW)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL006199   Anopheles gambiae Malaria mosquito  Agam\AGAP004066   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ013638
Orthologs in non-Dipteran Insects (EOG6D51SK)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB52280   Apis mellifera Western honey bee  Amel\GB52279   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG011140   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH27191   Atta cephalotes Leafcutter ant  Acep\ACEP17793   Camponotus floridanus Florida carpenter ant  Cflo\CFLO19162   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL15802   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL15801   Linepithema humile Argentine ant  Lhum\LH24694   Linepithema humile Argentine ant  Lhum\LH24693   Pogonomyrmex barbatus Red harvester ant  Pbar\PB15062   Pogonomyrmex barbatus Red harvester ant  Pbar\PB15061   Solenopsis invicta Red fire ant  Sinv\SINV10757   Solenopsis invicta Red fire ant  Sinv\SINV10740   Acyrthosiphon pisum Pea aphid  Apim\ACYPI009827   Bombyx mori Silkmoth  Bmor\BGIBMGA004748   Pediculus humanus Human body louse  Phum\PHUM226540   Tribolium castaneum Red flour beetle  Tcas\TC009677   Tribolium castaneum Red flour beetle  Tcas\TC009678   Tribolium castaneum Red flour beetle  Tcas\TC009676
Orthologs in non-Insect Arthropods (EOG689329)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_20079   Ixodes scapularis Deer tick  Isca\ISCW021414
Orthologs in non-Arthropod Metazoa (EOG6XWTQD)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\nrx-1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_024416gn   Danio rerio Zebrafish  Drer\nrxn2a   Danio rerio Zebrafish  Drer\nrxn1b   Danio rerio Zebrafish  Drer\nrxn3a   Danio rerio Zebrafish  Drer\ENSDARG00000063606   Danio rerio Zebrafish  Drer\nrxn3b   Danio rerio Zebrafish  Drer\nrxn1a   Danio rerio Zebrafish  Drer\nrxn2b   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000012291   Xenopus tropicalis Western clawed frog  Xtro\nrxn1   Xenopus tropicalis Western clawed frog  Xtro\nrxn2   Xenopus tropicalis Western clawed frog  Xtro\nrxn3   Gallus gallus Domestic chicken  Ggal\NRXN3   Gallus gallus Domestic chicken  Ggal\ENSGALG00000009107   Mus musculus House mouse  Mmus\ENSMUSG00000024109   Mus musculus House mouse  Mmus\Nrxn3   Mus musculus House mouse  Mmus\Nrxn2   Rattus norvegicus Norway rat  Rnor\Nrxn3   Rattus norvegicus Norway rat  Rnor\Nrxn2   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000027796   Homo sapiens Human  Hsap\NRXN2   Homo sapiens Human  Hsap\ENSG00000179915   Homo sapiens Human  Hsap\ENSG00000021645
Human Orthologs (3)
Gene OMIM HGNC Hsap\NRXN2     Hsap\ENSG00000179915     Hsap\ENSG00000021645
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD20957 Drosophila sechellia Dsec\GM26438 Drosophila erecta Dere\GG11140 Drosophila yakuba Dyak\GE10306 Drosophila ananassae Dana\GF23380 Drosophila pseudoobscura pseudoobscura Dpse\GA20059 Drosophila persimilis Dper\GL24221 Drosophila willistoni Dwil\GK11702 Drosophila virilis Dvir\GJ14339 Drosophila mojavensis Dmoj\GI21979 Drosophila grimshawi Dgri\GH22245
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	19299 w1118; P{XP}Nrx-1d08766 21977 w1118; P{EPg}Nrx-1HP35068 27502 y1 v1; P{TRiP.JF02652}attP2 22662 y1 w67c23; Mi{ET1}Nrx-1MB00002 32408 y1 sc* v1; P{TRiP.HMS00403}attP2
Harvard	- P{XP}Nrx-1d08766 - PBac{PB}Nrx-1c03581
VDRC	v4306 w1118; P{GD2619}v4306 v36328 w1118; P{GD14451}v36328 v36326 w1118; P{GD14451}v36326/TM3
Genomic Clones ( 2 )
	BACR30J14 BACR48C17 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 26 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LP03809 LP14275
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH15230 GH19272 HL01394 HL03581
Other clones	79943 84352 118237 119168 121332 156859 174523 280977 CK01.130B.F8 CK01.147B.C8 EC253629 EK101856 EK201801 EK212433 EK241455 EK259710 EK305953 EP09948 GH03851 GH05937
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0038975 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42646
Antibody Information
	polyclonal (Tian et al., 2013, Li et al., 2007, Sun et al., 2009, Zeng et al., 2007, Chen et al., 2010)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Nrx-1 CG7050 (Auld, 2001.3.7)
Source for database merge of
Additional comments
Other Comments
	Loss of Nrx-1 leads to defects in rhodopsin maturation, as a consequence of a reduction in chromophore levels. Neurexin interacts with apolipoprotein I (ApoLI) and is required for the appropriate level of ApoLI and ApoLII proteins. (Tian et al., 2013)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079725 NM_001170216 NM_001275908 NM_001275909 NM_001275910 NM_001275911 NM_001275912 NM_001275913 RefSeq (Proteins) • NP_524449 NP_001163687 NP_001262837 NP_001262838 NP_001262839 NP_001262840 NP_001262841 NP_001262842 DDBJ / EMBL / GenBank • AAF56006 AAL39876 ACZ94983 AGB96217 AGB96218 AGB96219 AGB96220 AGB96221 AGB96222 AI109124 AI260118 AW940146 AW944025 AY069731 CZ468744 Entrez Gene - A searchable database of RefSeq genes. • 42646 UniProtKB/TrEMBL • Q3KN41 Q8SZX4 Q9VCZ9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Epidermal growth factor-like domain (IPR000742) Laminin G domain (IPR001791) Concanavalin A-like lectin/glucanases superfamily (IPR008985) Concanavalin A-like lectin/glucanase, subgroup (IPR013320)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0038975 DRSC - Results from RNAi screens. • FBgn0038975 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0038975 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7050-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0038975 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42646 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42646 modMine - Data generated by the modENCODE project. • FBgn0038975
Synonyms & Secondary IDs ( 16 )
Reported As
Symbol Synonym	CG7050 (Arbeitman et al., 2004, Furlong et al., 2001, Tian et al., 2013, Zweier et al., 2009, Zeng et al., 2007, Perkins et al., 2009, Khanna et al., 2010, Ni et al., 2010.12.1) CT21808 (Hynes and Zhao, 2000) dnrx (Banovic et al., 2010, Sun et al., 2009, Li et al., 2007, Sun et al., 2011, Owald et al., 2012) dnrx-1 (Salinas et al., 2001) dnrx1 (Mozer and Sandstrom, 2012) Nrx (Lee et al., 2003, Mack et al., 2006, Wang et al., 2006) nrx (Tian et al., 2013, Chen et al., 2010) Nrx1 (Adolfsen et al., 2004) Nrx-1 (Geng and MacDonald, 2007, Zweier et al., 2009, Zeng et al., 2007, Zhou et al., 2008, Owald et al., 2012)
Name Synonym	Drosophila neurexin (Li et al., 2007) Neurexin (Banovic et al., 2010, Zeng et al., 2007, Sun et al., 2011) neurexin (Tian et al., 2013, Sun et al., 2009, Li et al., 2007, Chen et al., 2010, Owald et al., 2012) Neurexin 1 (Salinas et al., 2001, Zeng et al., 2007, Khanna et al., 2010, Khanna et al., 2010) neurexin 1 (Mozer and Sandstrom, 2012) Neurexin-1 (Zeng et al., 2007) Neurexin-like (Hynes and Zhao, 2000)
Secondary FlyBase IDs
References ( 48 )
Generate a list of	All references relating to this gene ( 48 )
List References by type	Research paper  ( 21 ) Supplementary material  ( 8 ) Review  ( 1 ) Personal communication to FlyBase  ( 13 ) Abstract  ( 1 ) FlyBase analysis  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 5 )
	Tian et al., 2013, Neuron 77(2): 311--322 Neurexin Regulates Visual Function via Mediating Retinoid Transport to Promote Rhodopsin Maturation. [FBrf0220614] Koper et al., 2012, PLoS ONE 7(4): e36339 Analysis of Adhesion Molecules and Basement Membrane Contributions to Synaptic Adhesion at the Drosophila Embryonic NMJ. [FBrf0218212] Mozer and Sandstrom, 2012, Mol. Cell. Neurosci. 51(3-4): 89--100 Drosophila neuroligin 1 regulates synaptic growth and function in response to activity and phosphoinositide-3-kinase. [FBrf0219839] Owald et al., 2012, Nat. Neurosci. 15(9): 1219--1226 Cooperation of Syd-1 with Neurexin synchronizes pre- with postsynaptic assembly. [FBrf0219330] Sun et al., 2011, J. Neurosci. 31(2): 687--699 Neuroligin 2 is required for synapse development and function at the Drosophila neuromuscular junction. [FBrf0212770] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...