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Gene Dmel\CG6937

General Information
Symbol	Dmel\CG6937	Species	D. melanogaster
Name		Annotation symbol	CG6937
Feature type	protein_coding_gene	FlyBase ID	FBgn0038989
Gene Model Status	Current	Stock availability	2 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	94B5-94B5	Sequence location	3R:18,410,508..18,411,931 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG6937 (FBgn0038989). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: mRNA binding. There is experimental evidence that it is involved in the biological process: neurogenesis. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Nucleotide-binding, alpha-beta plait; RNA recognition motif domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, during early larval stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval trachea, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1635058_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG6937. Gene sequence location is 3R:18410508..18411931.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features BKN22289 HFA16140
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 94B5-94B5   Limits computationally determined from genome sequence between P{lacW}Dph5L4910 and P{lacW}GclmL0580
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG6937 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG6937-RA FBtr0084266  NM_142809   1294   356
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG6937-PA   FBpp0083659   39.6   356   10.49     NP_651066   AAF56024
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • RNA recognition motif domain (IPR000504) Nucleotide-binding, alpha-beta plait (IPR012677)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202006   AA264297   AA264892   AE014297 AAF56024   AY071293 AAL48915   BG640180   BI232103   BI236446   BP549999   BP550000   BQ103740   BT053677   CO266579   CO275919   EC197503   EC203436   EC210433   EC214959   EV582668   FD586282   FD586287   FD586725   FD586799   FD587448   GH741832   GH762504
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8SYV4 Q9VCY1
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0038989    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0038989 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, during early larval stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0038989 expression level Developmental Stage   Expression Level embryo 00-02hr    7643 embryo 02-04hr    2057 embryo 04-06hr    4703 embryo 06-08hr    5786 embryo 08-10hr    5705 embryo 10-12hr    5349 embryo 12-14hr    3434 embryo 14-16hr    1827 embryo 16-18hr    1507 embryo 18-20hr    1393 embryo 20-22hr    3010 embryo 22-24hr    2637 larva L1    5325 larva L2    2993 larva L3 12hr old    1891 larva L3 puffstage 1-2    861 larva L3 puffstage 3-6    1013 larva L3 puffstage 7-9    1261 white prepupae new    1128 white prepupae 12hr    1066 white prepupae 24hr    1100 pupae 2d postWPP    934 pupae 3d postWPP    510 pupae 4d postWPP    644 adult male 01day    480 adult male 05day    569 adult male 30day    466 adult female 01day    2882 adult female 05day    5966 adult female 30day    6070 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (7643) embryo 02-04hr  (2057) embryo 04-06hr  (4703) embryo 06-08hr  (5786) embryo 08-10hr  (5705) embryo 10-12hr  (5349) embryo 12-14hr  (3434) embryo 14-16hr  (1827) embryo 16-18hr  (1507) embryo 18-20hr  (1393) embryo 20-22hr  (3010) embryo 22-24hr  (2637) larva L1  (5325) larva L2  (2993) larva L3 12hr old  (1891) larva L3 puffstage 1-2  (861) larva L3 puffstage 3-6  (1013) larva L3 puffstage 7-9  (1261) white prepupae new  (1128) white prepupae 12hr  (1066) white prepupae 24hr  (1100) pupae 2d postWPP  (934) pupae 3d postWPP  (510) pupae 4d postWPP  (644) adult male 01day  (480) adult male 05day  (569) adult male 30day  (466) adult female 01day  (2882) adult female 05day  (5966) adult female 30day  (6070) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (7643) embryo 02-04hr  (2057) embryo 04-06hr  (4703) embryo 06-08hr  (5786) embryo 08-10hr  (5705) embryo 10-12hr  (5349) embryo 12-14hr  (3434) embryo 14-16hr  (1827) embryo 16-18hr  1507 embryo 18-20hr    1393 embryo 20-22hr  (3010) embryo 22-24hr  (2637) larva L1  (5325) larva L2  (2993) larva L3 12hr old  (1891) larva L3 puffstage 1-2    861 larva L3 puffstage 3-6    1013 larva L3 puffstage 7-9    1261 white prepupae new    1128 white prepupae 12hr    1066 white prepupae 24hr    1100 pupae 2d postWPP    934 pupae 3d postWPP    510 pupae 4d postWPP    644 adult male 01day    480 adult male 05day    569 adult male 30day    466 adult female 01day  (2882) adult female 05day  (5966) adult female 30day  (6070) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    7643 embryo 02-04hr    2057 embryo 04-06hr    4703 embryo 06-08hr    5786 embryo 08-10hr    5705 embryo 10-12hr    5349 embryo 12-14hr    3434 embryo 14-16hr    1827 embryo 16-18hr    1507 embryo 18-20hr    1393 embryo 20-22hr    3010 embryo 22-24hr    2637 larva L1    5325 larva L2    2993 larva L3 12hr old    1891 larva L3 puffstage 1-2    861 larva L3 puffstage 3-6    1013 larva L3 puffstage 7-9    1261 white prepupae new    1128 white prepupae 12hr    1066 white prepupae 24hr    1100 pupae 2d postWPP    934 pupae 3d postWPP    510 pupae 4d postWPP    644 adult male 01day    480 adult male 05day    569 adult male 30day    466 adult female 01day    2882 adult female 05day    5966 adult female 30day    6070 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    7643 embryo 02-04hr    2057 embryo 04-06hr    4703 embryo 06-08hr    5786 embryo 08-10hr    5705 embryo 10-12hr    5349 embryo 12-14hr    3434 embryo 14-16hr    1827 embryo 16-18hr    1507 embryo 18-20hr    1393 embryo 20-22hr    3010 embryo 22-24hr    2637 larva L1    5325 larva L2    2993 larva L3 12hr old    1891 larva L3 puffstage 1-2    861 larva L3 puffstage 3-6    1013 larva L3 puffstage 7-9    1261 white prepupae new    1128 white prepupae 12hr    1066 white prepupae 24hr    1100 pupae 2d postWPP    934 pupae 3d postWPP    510 pupae 4d postWPP    644 adult male 01day    480 adult male 05day    569 adult male 30day    466 adult female 01day    2882 adult female 05day    5966 adult female 30day    6070 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0038989 expression level Developmental Stage   Expression Level embryo 00-02hr    7643 embryo 02-04hr    2057 embryo 04-06hr    4703 embryo 06-08hr    5786 embryo 08-10hr    5705 embryo 10-12hr    5349 embryo 12-14hr    3434 embryo 14-16hr    1827 embryo 16-18hr    1507 embryo 18-20hr    1393 embryo 20-22hr    3010 embryo 22-24hr    2637 larva L1    5325 larva L2    2993 larva L3 12hr old    1891 larva L3 puffstage 1-2    861 larva L3 puffstage 3-6    1013 larva L3 puffstage 7-9    1261 white prepupae new    1128 white prepupae 12hr    1066 white prepupae 24hr    1100 pupae 2d postWPP    934 pupae 3d postWPP    510 pupae 4d postWPP    644 adult male 01day    480 adult male 05day    569 adult male 30day    466 adult female 01day    2882 adult female 05day    5966 adult female 30day    6070 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (7643) embryo 02-04hr  (2057) embryo 04-06hr  (4703) embryo 06-08hr  (5786) embryo 08-10hr  (5705) embryo 10-12hr  (5349) embryo 12-14hr  (3434) embryo 14-16hr  (1827) embryo 16-18hr  (1507) embryo 18-20hr  (1393) embryo 20-22hr  (3010) embryo 22-24hr  (2637) larva L1  (5325) larva L2  (2993) larva L3 12hr old  (1891) larva L3 puffstage 1-2  (861) larva L3 puffstage 3-6  (1013) larva L3 puffstage 7-9  (1261) white prepupae new  (1128) white prepupae 12hr  (1066) white prepupae 24hr  (1100) pupae 2d postWPP  (934) pupae 3d postWPP  (510) pupae 4d postWPP  (644) adult male 01day  (480) adult male 05day  (569) adult male 30day  (466) adult female 01day  (2882) adult female 05day  (5966) adult female 30day  (6070) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (7643) embryo 02-04hr  2057 embryo 04-06hr  (4703) embryo 06-08hr  (5786) embryo 08-10hr  (5705) embryo 10-12hr  (5349) embryo 12-14hr  (3434) embryo 14-16hr  1827 embryo 16-18hr  1507 embryo 18-20hr    1393 embryo 20-22hr  (3010) embryo 22-24hr  (2637) larva L1  (5325) larva L2  (2993) larva L3 12hr old  1891 larva L3 puffstage 1-2    861 larva L3 puffstage 3-6    1013 larva L3 puffstage 7-9    1261 white prepupae new    1128 white prepupae 12hr    1066 white prepupae 24hr    1100 pupae 2d postWPP    934 pupae 3d postWPP    510 pupae 4d postWPP    644 adult male 01day    480 adult male 05day    569 adult male 30day    466 adult female 01day  (2882) adult female 05day  (5966) adult female 30day  (6070) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    7643 embryo 02-04hr    2057 embryo 04-06hr    4703 embryo 06-08hr    5786 embryo 08-10hr    5705 embryo 10-12hr    5349 embryo 12-14hr    3434 embryo 14-16hr    1827 embryo 16-18hr    1507 embryo 18-20hr    1393 embryo 20-22hr    3010 embryo 22-24hr    2637 larva L1    5325 larva L2    2993 larva L3 12hr old    1891 larva L3 puffstage 1-2    861 larva L3 puffstage 3-6    1013 larva L3 puffstage 7-9    1261 white prepupae new    1128 white prepupae 12hr    1066 white prepupae 24hr    1100 pupae 2d postWPP    934 pupae 3d postWPP    510 pupae 4d postWPP    644 adult male 01day    480 adult male 05day    569 adult male 30day    466 adult female 01day    2882 adult female 05day    5966 adult female 30day    6070 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    7643 embryo 02-04hr    2057 embryo 04-06hr    4703 embryo 06-08hr    5786 embryo 08-10hr    5705 embryo 10-12hr    5349 embryo 12-14hr    3434 embryo 14-16hr    1827 embryo 16-18hr    1507 embryo 18-20hr    1393 embryo 20-22hr    3010 embryo 22-24hr    2637 larva L1    5325 larva L2    2993 larva L3 12hr old    1891 larva L3 puffstage 1-2    861 larva L3 puffstage 3-6    1013 larva L3 puffstage 7-9    1261 white prepupae new    1128 white prepupae 12hr    1066 white prepupae 24hr    1100 pupae 2d postWPP    934 pupae 3d postWPP    510 pupae 4d postWPP    644 adult male 01day    480 adult male 05day    569 adult male 30day    466 adult female 01day    2882 adult female 05day    5966 adult female 30day    6070 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0038989    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0038989 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval trachea, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0038989 expression level Tissue   Expression Level Larval Central Nervous System    136.3 Larval Midgut    38.4 Larval Hindgut    48.7 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    89 Larval Trachea    140.375 Larval Carcass    78.775 Adult Head    27.2 Adult Eye    24.475 Adult Brain    34.4 Adult Thoracic-Abdominal Ganglion    25.9 Adult Crop    31.4 Adult Midgut    45.6 Adult Hindgut    30.9 Adult Malpighian Tubules no informative data Adult Fat Body    58.9 Adult Salivary Gland no informative data Adult Heart    35.35 Adult VirginFemale Spermatheca    22.7 Adult InseminatedFemale Spermatheca    37.5 Adult Ovary    412.9 Adult Testis    22.2 Adult Male Accessory Gland    98.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    136.3 Larval Midgut    38.4 Larval Hindgut    48.7 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    89 Larval Trachea    140.375 Larval Carcass    78.775 Adult Head    27.2 Adult Eye    24.475 Adult Brain    34.4 Adult Thoracic-Abdominal Ganglion    25.9 Adult Crop    31.4 Adult Midgut    45.6 Adult Hindgut    30.9 Adult Malpighian Tubules no informative data Adult Fat Body    58.9 Adult Salivary Gland no informative data Adult Heart    35.35 Adult VirginFemale Spermatheca    22.7 Adult InseminatedFemale Spermatheca    37.5 Adult Ovary    412.9 Adult Testis    22.2 Adult Male Accessory Gland    98.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    136.3 Larval Midgut    38.4 Larval Hindgut    48.7 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    89 Larval Trachea    140.375 Larval Carcass    78.775 Adult Head    27.2 Adult Eye    24.475 Adult Brain    34.4 Adult Thoracic-Abdominal Ganglion    25.9 Adult Crop    31.4 Adult Midgut    45.6 Adult Hindgut    30.9 Adult Malpighian Tubules no informative data Adult Fat Body    58.9 Adult Salivary Gland no informative data Adult Heart    35.35 Adult VirginFemale Spermatheca    22.7 Adult InseminatedFemale Spermatheca    37.5 Adult Ovary    412.9 Adult Testis    22.2 Adult Male Accessory Gland    98.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    136.3 Larval Midgut    38.4 Larval Hindgut    48.7 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    89 Larval Trachea    140.375 Larval Carcass    78.775 Adult Head    27.2 Adult Eye    24.475 Adult Brain    34.4 Adult Thoracic-Abdominal Ganglion    25.9 Adult Crop    31.4 Adult Midgut    45.6 Adult Hindgut    30.9 Adult Malpighian Tubules no informative data Adult Fat Body    58.9 Adult Salivary Gland no informative data Adult Heart    35.35 Adult VirginFemale Spermatheca    22.7 Adult InseminatedFemale Spermatheca    37.5 Adult Ovary    412.9 Adult Testis    22.2 Adult Male Accessory Gland    98.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0038989 expression level Tissue   Expression Level Larval Central Nervous System    136.3 Larval Midgut    38.4 Larval Hindgut    48.7 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    89 Larval Trachea    140.375 Larval Carcass    78.775 Adult Head    27.2 Adult Eye    24.475 Adult Brain    34.4 Adult Thoracic-Abdominal Ganglion    25.9 Adult Crop    31.4 Adult Midgut    45.6 Adult Hindgut    30.9 Adult Malpighian Tubules no informative data Adult Fat Body    58.9 Adult Salivary Gland no informative data Adult Heart    35.35 Adult VirginFemale Spermatheca    22.7 Adult InseminatedFemale Spermatheca    37.5 Adult Ovary    412.9 Adult Testis    22.2 Adult Male Accessory Gland    98.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    136.3 Larval Midgut    38.4 Larval Hindgut    48.7 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    89 Larval Trachea    140.375 Larval Carcass    78.775 Adult Head    27.2 Adult Eye    24.475 Adult Brain    34.4 Adult Thoracic-Abdominal Ganglion    25.9 Adult Crop    31.4 Adult Midgut    45.6 Adult Hindgut    30.9 Adult Malpighian Tubules no informative data Adult Fat Body    58.9 Adult Salivary Gland no informative data Adult Heart    35.35 Adult VirginFemale Spermatheca    22.7 Adult InseminatedFemale Spermatheca    37.5 Adult Ovary    412.9 Adult Testis    22.2 Adult Male Accessory Gland    98.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    136.3 Larval Midgut    38.4 Larval Hindgut    48.7 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    89 Larval Trachea    140.375 Larval Carcass    78.775 Adult Head    27.2 Adult Eye    24.475 Adult Brain    34.4 Adult Thoracic-Abdominal Ganglion    25.9 Adult Crop    31.4 Adult Midgut    45.6 Adult Hindgut    30.9 Adult Malpighian Tubules no informative data Adult Fat Body    58.9 Adult Salivary Gland no informative data Adult Heart    35.35 Adult VirginFemale Spermatheca    22.7 Adult InseminatedFemale Spermatheca    37.5 Adult Ovary    412.9 Adult Testis    22.2 Adult Male Accessory Gland    98.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    136.3 Larval Midgut    38.4 Larval Hindgut    48.7 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    89 Larval Trachea    140.375 Larval Carcass    78.775 Adult Head    27.2 Adult Eye    24.475 Adult Brain    34.4 Adult Thoracic-Abdominal Ganglion    25.9 Adult Crop    31.4 Adult Midgut    45.6 Adult Hindgut    30.9 Adult Malpighian Tubules no informative data Adult Fat Body    58.9 Adult Salivary Gland no informative data Adult Heart    35.35 Adult VirginFemale Spermatheca    22.7 Adult InseminatedFemale Spermatheca    37.5 Adult Ovary    412.9 Adult Testis    22.2 Adult Male Accessory Gland    98.2 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules no informative data Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    27.2   NA  Eye    24.475   NA  Brain    34.4   136.3  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    25.9   NA  Crop    31.4   38.4  Midgut    45.6   48.7  Hindgut    30.9   no informative data  Malpighian Tubules    no informative data   no informative data  Fat Body    58.9   89  Salivary Gland    no informative data   NA  Heart    35.35   140.375  Trachea    NA   NA  VirginFemale Spermatheca    22.7   NA  InseminatedFemale Spermatheca    37.5   NA  Ovary    412.9   NA  Testis    22.2   NA  Male Accessory Gland    98.2   78.775  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_08
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0038989 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6937-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for CG6937 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL41407 CG6937GD12080 lethal | pupal stage, with Scer\GAL4pnr-MD237 CG6937GD12080 Other Phenotypes Allele neuroanatomy defective | larval stage, with Scer\GAL41407 CG6937GD12080 Phenotype manifest in Allele embryonic/larval neuroblast | larval stage, with Scer\GAL41407 CG6937GD12080 ganglion mother cell | larval stage, with Scer\GAL41407 CG6937GD12080
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of CG6937 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG6937 Class Mutagen Stocks Known lesion CG6937GD12080 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG6937KK102223 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6273 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD12080} NA P{KK102223} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
neurogenesis inferred from mutant phenotype (Neumüller et al., 2011)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
mRNA binding inferred from sequence or structural similarity (Lasko, 2000) nucleic acid binding inferred from electronic annotation with InterPro:IPR000504 (FlyBase Curators et al., 2004-) nucleotide binding inferred from electronic annotation with InterPro:IPR012677 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG6937 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67616 DroID - A comprehensive database of gene and protein interactions. • FBgn0038989 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42662
Orthologs
Genome-wide drosophilid orthologs	Dana\GF18861 Dere\GG11148 Dgri\GH22444 Dmoj\GI22244 Dper\GL13812 Dpse\GA19968 Dsec\GM26446 Dsim\GD20965 Dvir\GJ23050 Dwil\GK11303 Dyak\GE10313
Curated drosophilid orthologs	Dpse\GA19968
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL012100-PA Aedes aegypti (mosquito) AGAP006090-PA Anopheles gambiae (mosquito) XP_624686.1 Apis mellifera (honey bee) XP_001949378.1 Acyrthosiphon pisum (pea aphid) 132769 Branchiostoma floridae (lancelet) ENSBTAP00000031516 Bos taurus (bovine) CAL0002077 Candida albicans (a form of yeast) CBP10843 Caenorhabditis briggsae (nematode) CE01075 Caenorhabditis elegans (worm) ENSCAFP00000007026 Canis familiaris (dog) CAGL0L03806g Candida glabrata (haploid yeast) ENSCINP00000003753 Ciona intestinalis (sea squirt) JA18878 Caenorhabditis japonica (nematode) CPIJ015549 Culex pipens (mosquito) ENSCPOP00000006740 Cavia porcellus (guinea pig) RP06770 Caenorhabditis remanei (nematode) ENSCSAVP00000002328 Ciona savignyi (sedentary tunicate) 150391 Capitella spl (polychaete worm) DDB0217706 Dictyostelium discoideum (amoeba) DEHA2A05720g Debaryomyces Hansenii (yeast) 222793 Daphnia pulex (daphnia) ENSDARP00000059548 Danio rerio (zebra fish) ENSECAP00000016035 Equus caballus (horse) ENSGALP00000019016 Gallus gallus (chicken) ENSP00000285814 Homo sapiens (human) 134785 Lottia gigantea (owl limpet) ENSMODP00000036295 Monodelphis domestica (gray opossum) ENSMMUP00000027538 Macaca mulatta (rhesus monkey) ENSMUSP00000027626 Mus musculus (house mouse) 181320 Nematostella vectensis (starlet anemone) XP_001600029.1 Nasonia vitripennis (wasp) PP21820 Pristionchus pacificus (nematode) ENSPPYP00000020812 Pongo pygmaeus (orangutan) 138735 Phytophthora sojae (root rot pathogen) ENSPTRP00000021260 Pan troglodytes (chimpanzee) ENSRNOP00000058336 Rattus norvegicus (norway rat) SPCC1827.05c Schizosaccharomyces pombe (fission yeast) XP_793694.2 Strongylocentrotus purpuratus (purple sea urchin) ENSTNIP00000020989 Tetraodon nigroviridis (green spotted pufferfish) 261569 Thalassiosira pseudonana (marine diatom) ENSTRUP00000012510 Takifugu rubripes (pufferfish Takifugu) 21.m00370 Tetrahymena thermophila (ciliate protozoa) 87349.m00158 Trichomonas vaginalis (parasitic flagellated protozoan) 90756.m00172 Trichomonas vaginalis (parasitic flagellated protozoan) YALI0F14245g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV18432 LH24948 FBgn0228181 FBgn0213314 FBgn0210152 FBgn0192421 FBgn0181299 JGI_V11_222793 FBgn0079964 FBgn0151417 FBgn0144972 FBgn0129902 FBgn0103449 FBgn0095875 CPIJ015549 BGIBMGA004635 ACYPI006149 GB14098 AGAP006090 AAEL012100 PB21465 GLEAN_04828
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
VDRC	v103728 P{KK102223}VIE-260B v22315 w1118; P{GD12080}v22315
Genomic Clones ( 2 )
	BACR02L12 BACR48C17 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 23 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE32504
Other clones	FI03269
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD03888 LD07980 LD09522 RE28119 SD11143
Other clones	35861 146239 149632 CK01.144C.A2 Dmel_dig_018060_0599_2988 EK119133 EK146928 FGM104G01 RM04253 RM04353 RM04653 RM04853 RM04953 RP001044751 RP001051479 UUGC1151
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0038989 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42662
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	Identified as a potential component of the hh signalling pathway in a genome-wide RNAi screen. dsRNA made from templates generated with primers directed affects the extent of expression of a hh signaling reporter construct in Clone 8 cells. (Nybakken et al., 2005)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_142809 RefSeq (Proteins) • NP_651066 DDBJ / EMBL / GenBank • AAF56024 AAL48915 AY071293 BI236446 Entrez Gene - A searchable database of RefSeq genes. • 42662 UniProtKB/TrEMBL • Q8SYV4 Q9VCY1
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • RNA recognition motif domain (IPR000504) Nucleotide-binding, alpha-beta plait (IPR012677)
Linkouts
	BioGRID - A database of protein and genetic interactions • 67616 DroID - A comprehensive database of gene and protein interactions. • FBgn0038989 DRSC - Results from RNAi screens. • FBgn0038989 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0038989 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6937-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0038989 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42662 InParanoid A subset of ortholog calls from InParanoid. • AAEL012100-PA Aedes aegypti (mosquito) AGAP006090-PA Anopheles gambiae (mosquito) XP_624686.1 Apis mellifera (honey bee) XP_001949378.1 Acyrthosiphon pisum (pea aphid) 132769 Branchiostoma floridae (lancelet) ENSBTAP00000031516 Bos taurus (bovine) CAL0002077 Candida albicans (a form of yeast) CBP10843 Caenorhabditis briggsae (nematode) CE01075 Caenorhabditis elegans (worm) ENSCAFP00000007026 Canis familiaris (dog) CAGL0L03806g Candida glabrata (haploid yeast) ENSCINP00000003753 Ciona intestinalis (sea squirt) JA18878 Caenorhabditis japonica (nematode) CPIJ015549 Culex pipens (mosquito) ENSCPOP00000006740 Cavia porcellus (guinea pig) RP06770 Caenorhabditis remanei (nematode) ENSCSAVP00000002328 Ciona savignyi (sedentary tunicate) 150391 Capitella spl (polychaete worm) DDB0217706 Dictyostelium discoideum (amoeba) DEHA2A05720g Debaryomyces Hansenii (yeast) 222793 Daphnia pulex (daphnia) ENSDARP00000059548 Danio rerio (zebra fish) ENSECAP00000016035 Equus caballus (horse) ENSGALP00000019016 Gallus gallus (chicken) ENSP00000285814 Homo sapiens (human) 134785 Lottia gigantea (owl limpet) ENSMODP00000036295 Monodelphis domestica (gray opossum) ENSMMUP00000027538 Macaca mulatta (rhesus monkey) ENSMUSP00000027626 Mus musculus (house mouse) 181320 Nematostella vectensis (starlet anemone) XP_001600029.1 Nasonia vitripennis (wasp) PP21820 Pristionchus pacificus (nematode) ENSPPYP00000020812 Pongo pygmaeus (orangutan) 138735 Phytophthora sojae (root rot pathogen) ENSPTRP00000021260 Pan troglodytes (chimpanzee) ENSRNOP00000058336 Rattus norvegicus (norway rat) SPCC1827.05c Schizosaccharomyces pombe (fission yeast) XP_793694.2 Strongylocentrotus purpuratus (purple sea urchin) ENSTNIP00000020989 Tetraodon nigroviridis (green spotted pufferfish) 261569 Thalassiosira pseudonana (marine diatom) ENSTRUP00000012510 Takifugu rubripes (pufferfish Takifugu) 21.m00370 Tetrahymena thermophila (ciliate protozoa) 87349.m00158 Trichomonas vaginalis (parasitic flagellated protozoan) 90756.m00172 Trichomonas vaginalis (parasitic flagellated protozoan) YALI0F14245g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42662 modMine - Data generated by the modENCODE project. • FBgn0038989 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV18432 LH24948 FBgn0228181 FBgn0213314 FBgn0210152 FBgn0192421 FBgn0181299 JGI_V11_222793 FBgn0079964 FBgn0151417 FBgn0144972 FBgn0129902 FBgn0103449 FBgn0095875 CPIJ015549 BGIBMGA004635 ACYPI006149 GB14098 AGAP006090 AAEL012100 PB21465 GLEAN_04828
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	cg6937 (Lasko, 2000) CG6937 (Nybakken et al., 2005, Somma et al., 2008, McGraw et al., 2008, Keleman et al., 2009.8.5)
Name Synonym
Secondary FlyBase IDs
References ( 18 )
Research paper	Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] McGraw et al., 2008, Genetics 179(3): 1395--1408 Post-mating gene expression profiles of female Drosophila melanogaster in response to time and to four male accessory gland proteins. [FBrf0207105] Somma et al., 2008, PLoS Genet. 4(7): e1000126 Identification of Drosophila mitotic genes by combining co-expression analysis and RNA interference. [FBrf0206064] Nybakken et al., 2005, Nature Genetics 37(12): 1323--1332 A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway. [FBrf0191274] Lasko, 2000, J. Cell Biol. 150(2): F51--F56 The Drosophila melanogaster genome: translation factors and RNA binding proteins. [FBrf0129923]
Supplementary material	Neumüller et al., 2011, Cell Stem Cell 8(5): Supplemental Table S1. [FBrf0214431] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]
Curated genome annotation	Lasko, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126679]