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Gene Dmel\Ccap

General Information
Symbol	Dmel\Ccap	Species	D. melanogaster
Name	Cardioacceleratory peptide	Annotation symbol	CG4910
Feature type	protein_coding_gene	FlyBase ID	FBgn0039007
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	94C1-94C1	Sequence location	3R:18,526,304..18,527,806 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Cardioacceleratory peptide is referred to in FlyBase by the symbol Dmel\Ccap (CG4910, FBgn0039007). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: neuropeptide hormone activity. Based on sequence similarity, it is predicted to be involved in the biological process: positive regulation of heart contraction; regulation of heart contraction; neuropeptide signaling pathway. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Crustacean cardioactive peptide. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of no expression detected. Peak expression observed at stages throughout the larval period, at stages throughout the pupal period, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult thoracico-abdominal ganglion. Comments on Affy2 ProbeSet: ProbeSet 1637339_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Ccap. Gene sequence location is 3R:18526304..18527806.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features HFA15674 BKN30176
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 94C1-94C1   Limits computationally determined from genome sequence between P{lacW}GclmL0580 and P{EP}hhEP3521
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Ccap for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Ccap-RA FBtr0084333  NM_142826   1249   155
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Ccap-PA   FBpp0083726   18.0   155   8.90     NP_651083   AAF56045
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Crustacean cardioactive peptide (IPR024276)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF56045   BT024429   CK134592   EL870482   EL870483   GH752269   GH810376   GH813386   GH853708   GH873597   GH885739   GH888372
UniProtKB/Swiss-Prot	Q9VCW0
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference third instar larval stage   ventral nerve cord | restricted   (Dewey et al., 2004) brain | restricted   (Dewey et al., 2004) adult stage   neuron | subset of thoracico-abdominal ganglion   (Peterson et al., 2002) Comment:~ 3 neurons at the posterior tip of the thoracico-abdominal ganglion are labeled
Additional Descriptive Data
	~ 3 Ccap-positive neurons are observed in the posterior abdominal neuromere of the thoracico-abdominal ganglion. (Peterson et al., 2002)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0039007    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0039007 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of no expression detected. Peak expression observed at stages throughout the larval period, at stages throughout the pupal period, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0039007 expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    5 embryo 10-12hr    59 embryo 12-14hr    84 embryo 14-16hr    32 embryo 16-18hr    51 embryo 18-20hr    38 embryo 20-22hr    65 embryo 22-24hr    90 larva L1    105 larva L2    49 larva L3 12hr old    30 larva L3 puffstage 1-2    36 larva L3 puffstage 3-6    65 larva L3 puffstage 7-9    122 white prepupae new    152 white prepupae 12hr    94 white prepupae 24hr    132 pupae 2d postWPP    189 pupae 3d postWPP    221 pupae 4d postWPP    136 adult male 01day    142 adult male 05day    139 adult male 30day    134 adult female 01day    35 adult female 05day    21 adult female 30day    9 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    5 embryo 10-12hr    59 embryo 12-14hr    84 embryo 14-16hr    32 embryo 16-18hr    51 embryo 18-20hr    38 embryo 20-22hr    65 embryo 22-24hr    90 larva L1  105 larva L2    49 larva L3 12hr old    30 larva L3 puffstage 1-2    36 larva L3 puffstage 3-6    65 larva L3 puffstage 7-9  (122) white prepupae new  (152) white prepupae 12hr    94 white prepupae 24hr  (132) pupae 2d postWPP  (189) pupae 3d postWPP  (221) pupae 4d postWPP  (136) adult male 01day  (142) adult male 05day  (139) adult male 30day  (134) adult female 01day    35 adult female 05day    21 adult female 30day    9 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    5 embryo 10-12hr    59 embryo 12-14hr    84 embryo 14-16hr    32 embryo 16-18hr    51 embryo 18-20hr    38 embryo 20-22hr    65 embryo 22-24hr    90 larva L1    105 larva L2    49 larva L3 12hr old    30 larva L3 puffstage 1-2    36 larva L3 puffstage 3-6    65 larva L3 puffstage 7-9    122 white prepupae new    152 white prepupae 12hr    94 white prepupae 24hr    132 pupae 2d postWPP    189 pupae 3d postWPP    221 pupae 4d postWPP    136 adult male 01day    142 adult male 05day    139 adult male 30day    134 adult female 01day    35 adult female 05day    21 adult female 30day    9 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    5 embryo 10-12hr    59 embryo 12-14hr    84 embryo 14-16hr    32 embryo 16-18hr    51 embryo 18-20hr    38 embryo 20-22hr    65 embryo 22-24hr    90 larva L1    105 larva L2    49 larva L3 12hr old    30 larva L3 puffstage 1-2    36 larva L3 puffstage 3-6    65 larva L3 puffstage 7-9    122 white prepupae new    152 white prepupae 12hr    94 white prepupae 24hr    132 pupae 2d postWPP    189 pupae 3d postWPP    221 pupae 4d postWPP    136 adult male 01day    142 adult male 05day    139 adult male 30day    134 adult female 01day    35 adult female 05day    21 adult female 30day    9 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    5 embryo 10-12hr    59 embryo 12-14hr    84 embryo 14-16hr    32 embryo 16-18hr    51 embryo 18-20hr    38 embryo 20-22hr    65 embryo 22-24hr    90 larva L1    105 larva L2    49 larva L3 12hr old    30 larva L3 puffstage 1-2    36 larva L3 puffstage 3-6    65 larva L3 puffstage 7-9    122 white prepupae new    152 white prepupae 12hr    94 white prepupae 24hr    132 pupae 2d postWPP    189 pupae 3d postWPP    221 pupae 4d postWPP    136 adult male 01day    142 adult male 05day    139 adult male 30day    134 adult female 01day    35 adult female 05day    21 adult female 30day    9 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0039007 expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    5 embryo 10-12hr    59 embryo 12-14hr    84 embryo 14-16hr    32 embryo 16-18hr    51 embryo 18-20hr    38 embryo 20-22hr    65 embryo 22-24hr    90 larva L1    105 larva L2    49 larva L3 12hr old    30 larva L3 puffstage 1-2    36 larva L3 puffstage 3-6    65 larva L3 puffstage 7-9    122 white prepupae new    152 white prepupae 12hr    94 white prepupae 24hr    132 pupae 2d postWPP    189 pupae 3d postWPP    221 pupae 4d postWPP    136 adult male 01day    142 adult male 05day    139 adult male 30day    134 adult female 01day    35 adult female 05day    21 adult female 30day    9 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    5 embryo 10-12hr    59 embryo 12-14hr    84 embryo 14-16hr    32 embryo 16-18hr    51 embryo 18-20hr    38 embryo 20-22hr    65 embryo 22-24hr    90 larva L1  105 larva L2    49 larva L3 12hr old    30 larva L3 puffstage 1-2    36 larva L3 puffstage 3-6    65 larva L3 puffstage 7-9  122 white prepupae new  (152) white prepupae 12hr    94 white prepupae 24hr  132 pupae 2d postWPP  (189) pupae 3d postWPP  (221) pupae 4d postWPP  136 adult male 01day  142 adult male 05day  139 adult male 30day  134 adult female 01day    35 adult female 05day    21 adult female 30day    9 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    5 embryo 10-12hr    59 embryo 12-14hr    84 embryo 14-16hr    32 embryo 16-18hr    51 embryo 18-20hr    38 embryo 20-22hr    65 embryo 22-24hr    90 larva L1    105 larva L2    49 larva L3 12hr old    30 larva L3 puffstage 1-2    36 larva L3 puffstage 3-6    65 larva L3 puffstage 7-9    122 white prepupae new    152 white prepupae 12hr    94 white prepupae 24hr    132 pupae 2d postWPP    189 pupae 3d postWPP    221 pupae 4d postWPP    136 adult male 01day    142 adult male 05day    139 adult male 30day    134 adult female 01day    35 adult female 05day    21 adult female 30day    9 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    5 embryo 10-12hr    59 embryo 12-14hr    84 embryo 14-16hr    32 embryo 16-18hr    51 embryo 18-20hr    38 embryo 20-22hr    65 embryo 22-24hr    90 larva L1    105 larva L2    49 larva L3 12hr old    30 larva L3 puffstage 1-2    36 larva L3 puffstage 3-6    65 larva L3 puffstage 7-9    122 white prepupae new    152 white prepupae 12hr    94 white prepupae 24hr    132 pupae 2d postWPP    189 pupae 3d postWPP    221 pupae 4d postWPP    136 adult male 01day    142 adult male 05day    139 adult male 30day    134 adult female 01day    35 adult female 05day    21 adult female 30day    9 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    5 embryo 10-12hr    59 embryo 12-14hr    84 embryo 14-16hr    32 embryo 16-18hr    51 embryo 18-20hr    38 embryo 20-22hr    65 embryo 22-24hr    90 larva L1    105 larva L2    49 larva L3 12hr old    30 larva L3 puffstage 1-2    36 larva L3 puffstage 3-6    65 larva L3 puffstage 7-9    122 white prepupae new    152 white prepupae 12hr    94 white prepupae 24hr    132 pupae 2d postWPP    189 pupae 3d postWPP    221 pupae 4d postWPP    136 adult male 01day    142 adult male 05day    139 adult male 30day    134 adult female 01day    35 adult female 05day    21 adult female 30day    9 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0039007    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0039007 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult thoracico-abdominal ganglion. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0039007 expression level Tissue   Expression Level Larval Central Nervous System    86.85 Larval Midgut    8.2 Larval Hindgut    1.3 Larval Malpighian Tubules    6.3 Larval Fat Body    7.9 Larval Salivary Gland    2 Larval Trachea    2.875 Larval Carcass    3.5 Adult Head no informative data Adult Eye    2.025 Adult Brain    33.6 Adult Thoracic-Abdominal Ganglion    102.6 Adult Crop    2.9 Adult Midgut    4.5 Adult Hindgut    4.6 Adult Malpighian Tubules    4.6 Adult Fat Body    5.7 Adult Salivary Gland no informative data Adult Heart    7.8 Adult VirginFemale Spermatheca    4.2 Adult InseminatedFemale Spermatheca    2.3 Adult Ovary    0.6 Adult Testis    29.6 Adult Male Accessory Gland    2.4 Adult Carcass    6.1 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    86.85 Larval Midgut    8.2 Larval Hindgut    1.3 Larval Malpighian Tubules    6.3 Larval Fat Body    7.9 Larval Salivary Gland    2 Larval Trachea    2.875 Larval Carcass    3.5 Adult Head no informative data Adult Eye    2.025 Adult Brain    33.6 Adult Thoracic-Abdominal Ganglion    102.6 Adult Crop    2.9 Adult Midgut    4.5 Adult Hindgut    4.6 Adult Malpighian Tubules    4.6 Adult Fat Body    5.7 Adult Salivary Gland no informative data Adult Heart    7.8 Adult VirginFemale Spermatheca    4.2 Adult InseminatedFemale Spermatheca    2.3 Adult Ovary    0.6 Adult Testis    29.6 Adult Male Accessory Gland    2.4 Adult Carcass    6.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    86.85 Larval Midgut    8.2 Larval Hindgut    1.3 Larval Malpighian Tubules    6.3 Larval Fat Body    7.9 Larval Salivary Gland    2 Larval Trachea    2.875 Larval Carcass    3.5 Adult Head no informative data Adult Eye    2.025 Adult Brain    33.6 Adult Thoracic-Abdominal Ganglion    102.6 Adult Crop    2.9 Adult Midgut    4.5 Adult Hindgut    4.6 Adult Malpighian Tubules    4.6 Adult Fat Body    5.7 Adult Salivary Gland no informative data Adult Heart    7.8 Adult VirginFemale Spermatheca    4.2 Adult InseminatedFemale Spermatheca    2.3 Adult Ovary    0.6 Adult Testis    29.6 Adult Male Accessory Gland    2.4 Adult Carcass    6.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    86.85 Larval Midgut    8.2 Larval Hindgut    1.3 Larval Malpighian Tubules    6.3 Larval Fat Body    7.9 Larval Salivary Gland    2 Larval Trachea    2.875 Larval Carcass    3.5 Adult Head no informative data Adult Eye    2.025 Adult Brain    33.6 Adult Thoracic-Abdominal Ganglion    102.6 Adult Crop    2.9 Adult Midgut    4.5 Adult Hindgut    4.6 Adult Malpighian Tubules    4.6 Adult Fat Body    5.7 Adult Salivary Gland no informative data Adult Heart    7.8 Adult VirginFemale Spermatheca    4.2 Adult InseminatedFemale Spermatheca    2.3 Adult Ovary    0.6 Adult Testis    29.6 Adult Male Accessory Gland    2.4 Adult Carcass    6.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0039007 expression level Tissue   Expression Level Larval Central Nervous System    86.85 Larval Midgut    8.2 Larval Hindgut    1.3 Larval Malpighian Tubules    6.3 Larval Fat Body    7.9 Larval Salivary Gland    2 Larval Trachea    2.875 Larval Carcass    3.5 Adult Head no informative data Adult Eye    2.025 Adult Brain    33.6 Adult Thoracic-Abdominal Ganglion    102.6 Adult Crop    2.9 Adult Midgut    4.5 Adult Hindgut    4.6 Adult Malpighian Tubules    4.6 Adult Fat Body    5.7 Adult Salivary Gland no informative data Adult Heart    7.8 Adult VirginFemale Spermatheca    4.2 Adult InseminatedFemale Spermatheca    2.3 Adult Ovary    0.6 Adult Testis    29.6 Adult Male Accessory Gland    2.4 Adult Carcass    6.1 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    86.85 Larval Midgut    8.2 Larval Hindgut    1.3 Larval Malpighian Tubules    6.3 Larval Fat Body    7.9 Larval Salivary Gland    2 Larval Trachea    2.875 Larval Carcass    3.5 Adult Head no informative data Adult Eye    2.025 Adult Brain    33.6 Adult Thoracic-Abdominal Ganglion    102.6 Adult Crop    2.9 Adult Midgut    4.5 Adult Hindgut    4.6 Adult Malpighian Tubules    4.6 Adult Fat Body    5.7 Adult Salivary Gland no informative data Adult Heart    7.8 Adult VirginFemale Spermatheca    4.2 Adult InseminatedFemale Spermatheca    2.3 Adult Ovary    0.6 Adult Testis    29.6 Adult Male Accessory Gland    2.4 Adult Carcass    6.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    86.85 Larval Midgut    8.2 Larval Hindgut    1.3 Larval Malpighian Tubules    6.3 Larval Fat Body    7.9 Larval Salivary Gland    2 Larval Trachea    2.875 Larval Carcass    3.5 Adult Head no informative data Adult Eye    2.025 Adult Brain    33.6 Adult Thoracic-Abdominal Ganglion    102.6 Adult Crop    2.9 Adult Midgut    4.5 Adult Hindgut    4.6 Adult Malpighian Tubules    4.6 Adult Fat Body    5.7 Adult Salivary Gland no informative data Adult Heart    7.8 Adult VirginFemale Spermatheca    4.2 Adult InseminatedFemale Spermatheca    2.3 Adult Ovary    0.6 Adult Testis    29.6 Adult Male Accessory Gland    2.4 Adult Carcass    6.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    86.85 Larval Midgut    8.2 Larval Hindgut    1.3 Larval Malpighian Tubules    6.3 Larval Fat Body    7.9 Larval Salivary Gland    2 Larval Trachea    2.875 Larval Carcass    3.5 Adult Head no informative data Adult Eye    2.025 Adult Brain    33.6 Adult Thoracic-Abdominal Ganglion    102.6 Adult Crop    2.9 Adult Midgut    4.5 Adult Hindgut    4.6 Adult Malpighian Tubules    4.6 Adult Fat Body    5.7 Adult Salivary Gland no informative data Adult Heart    7.8 Adult VirginFemale Spermatheca    4.2 Adult InseminatedFemale Spermatheca    2.3 Adult Ovary    0.6 Adult Testis    29.6 Adult Male Accessory Gland    2.4 Adult Carcass    6.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head no informative data Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    no informative data   NA  Eye    2.025   NA  Brain    33.6   86.85  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    102.6   NA  Crop    2.9   8.2  Midgut    4.5   1.3  Hindgut    4.6   6.3  Malpighian Tubules    4.6   7.9  Fat Body    5.7   2  Salivary Gland    no informative data   NA  Heart    7.8   2.875  Trachea    NA   NA  VirginFemale Spermatheca    4.2   NA  InseminatedFemale Spermatheca    2.3   NA  Ovary    0.6   NA  Testis    29.6   NA  Male Accessory Gland    2.4   3.5  Carcass    6.1 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_24
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039007 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4910-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable CcapEY15558 Sterility Allele fertile CcapEY15558 Phenotype manifest in Allele
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of Ccap Class Mutagen Stocks Known lesion CcapEY15558 P-element activity 1 -- CcapMI01341 1 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Ccap Class Mutagen Stocks Known lesion CcapJF03248 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CcapGD6801 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6192 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD6801} NA P{TRiP.JF03248} NA characterization construct P{Ccap-GAL80.L} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}CcapEY15558 NA miscellaneous insertions Mi{MIC}CcapMI01341 NA
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
neuropeptide hormone activity inferred from sequence or structural similarity (vanden Broeck, 2001) inferred from sequence or structural similarity with EMBL:AF071800 (FlyBase, 1992-) inferred from sequence or structural similarity with UniProtKB:Q8WRC7 (assigned by UniProtKB) (Dewey et al., 2004) non-traceable author statement (Hewes and Taghert, 2001)
Biological Process
CV term Evidence References
neuropeptide signaling pathway inferred from sequence or structural similarity (vanden Broeck, 2001) positive regulation of heart contraction inferred from sequence or structural similarity with UniProtKB:Q7KRY7 AND inferred from sequence or structural similarity with UniProt:Q8WRC7 (assigned by UniProtKB) (Dewey et al., 2004) regulation of heart contraction inferred from sequence or structural similarity with EMBL:AF071800 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
extracellular region inferred from sequence or structural similarity with UniProtKB:Q7KRY7 AND inferred from sequence or structural similarity with UniProt:Q8WRC7 (assigned by UniProtKB) (Dewey et al., 2004)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Ccap allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67633 DroID - A comprehensive database of gene and protein interactions. • FBgn0039007 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42683
Orthologs
Genome-wide drosophilid orthologs	Dana\GF16697 Dere\GG12496 Dgri\GH18507 Dmoj\GI24352 Dper\GL23784 Dpse\GA18518 Dsec\GM23628 Dsim\GD18435 Dvir\GJ24364 Dwil\GK11630 Dyak\GE24016
Curated drosophilid orthologs	Dpse\GA18518
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL000630-PA Aedes aegypti (mosquito) AGAP009729-PA Anopheles gambiae (mosquito) BGIBMGA009606-PA Bombyx mori (silk worm) CPIJ005842 Culex pipens (mosquito) CPIJ019809 Culex pipens (mosquito) XP_975431.1 Tribolium castaneum (red flour beetle) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • ISCW010619 FBgn0241158 FBgn0213641 FBgn0211444 FBgn0189959 FBgn0178493 JGI_V11_300598 FBgn0078520 FBgn0161374 FBgn0147075 FBgn0125974 FBgn0104784 FBgn0093718 CPIJ019809 CPIJ005842 BGIBMGA009606 ACYPI53853 GB18160 CCAP AAEL000630 PHUM173410 GLEAN_01088
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	29569 y1 v1; P{TRiP.JF03248}attP2 21144 y1 w67c23; P{EPgy2}CcapEY15558 35062 y1 w*; Mi{MIC}CcapMI01341/TM3, Sb1 Ser1
Genomic Clones ( 2 )
	BACR02L12 BACR23F10 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 10 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP02558
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	IP02560 RE68888 RP003054811 RP003093362 RP003138645 RP003142153 RP003301659 RP003502641 RP003543418
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0039007 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42683
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Ccap CG4910 (Ewer, 2001.3.5)
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_142826 RefSeq (Proteins) • NP_651083 DDBJ / EMBL / GenBank • AAF56045 Entrez Gene - A searchable database of RefSeq genes. • 42683 UniProtKB/Swiss-Prot • Q9VCW0
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Crustacean cardioactive peptide (IPR024276)
Linkouts
	BioGRID - A database of protein and genetic interactions • 67633 DroID - A comprehensive database of gene and protein interactions. • FBgn0039007 DRSC - Results from RNAi screens. • FBgn0039007 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039007 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4910-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0039007 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42683 InParanoid A subset of ortholog calls from InParanoid. • AAEL000630-PA Aedes aegypti (mosquito) AGAP009729-PA Anopheles gambiae (mosquito) BGIBMGA009606-PA Bombyx mori (silk worm) CPIJ005842 Culex pipens (mosquito) CPIJ019809 Culex pipens (mosquito) XP_975431.1 Tribolium castaneum (red flour beetle) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /sturtevant/ccap1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42683 modMine - Data generated by the modENCODE project. • FBgn0039007 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • ISCW010619 FBgn0241158 FBgn0213641 FBgn0211444 FBgn0189959 FBgn0178493 JGI_V11_300598 FBgn0078520 FBgn0161374 FBgn0147075 FBgn0125974 FBgn0104784 FBgn0093718 CPIJ019809 CPIJ005842 BGIBMGA009606 ACYPI53853 GB18160 CCAP AAEL000630 PHUM173410 GLEAN_01088
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	CCAP (Dulcis and Levine, 2003, Luan et al., 2006, Zhang et al., 2000, Casci, 2004, Park et al., 2004, Johnson et al., 2003, Hewes et al., 2003, Peterson et al., 2002, vanden Broeck, 2001, Ewer et al., 2001, Hoose et al., 2006, Luan et al., 2006, Davis et al., 2007, Luan et al., 2007, Peabody et al., 2007, Kim et al., 2006, Ewer, 2006, Voemel and Wegener, 2007, Zhao et al., 2008, Husain and Ewer, 2004, Dulcis et al., 2005, Luan et al., 2006, Park et al., 2008, Birse et al., 2006, Davis et al., 2007, Hari et al., 2008, Paré et al., 2009, Peabody et al., 2009, Johnson et al., 2005, Johnson et al., 2008, Rayburn et al., 2009, Veenstra et al., 2008, Jorgensen et al., 2006, Morton et al., 2008, Hector et al., 2009) Ccap (Santos et al., 2007, Junion et al., 2007, Gauthier and Hewes, 2006, Wegener and Gorbashov, 2008) ccap (Melcher and Pankratz, 2005) CG4910 (Vanden Broeck et al., 2001, Perkins et al., 2009, Wegener and Gorbashov, 2008) DmCCAP (Park et al., 2003)
Name Synonym	Cardioacceleratory peptide (Park et al., 2003, Gauthier and Hewes, 2006) CCAP prepropeptide (Santos et al., 2007) Crustacean Cardioactive Peptide (Ewer et al., 2004, Peabody et al., 2007, Johnson et al., 2008) crustacean cardioactive peptide (Davis et al., 2007, Kim et al., 2006, Park et al., 2008, Birse et al., 2006, Paré et al., 2009, Johnson et al., 2005, Veenstra, 2009, Rayburn et al., 2009, Vömel and Wegener, 2008, Zhou et al., 2009, Hector et al., 2009)
Secondary FlyBase IDs
References ( 72 )
Generate a list of	All references relating to this gene ( 72 )
List References by type	Research paper  ( 42 ) Supplementary material  ( 4 ) Review  ( 7 ) Personal communication to FlyBase  ( 4 ) Abstract  ( 12 ) FlyBase analysis  ( 1 ) Computer file  ( 1 )
Recent research papers ( 1 )
	Veverytsa and Allan, 2011, Development 138(15): 3147--3157 Retrograde BMP signaling controls Drosophila behavior through regulation of a peptide hormone battery. [FBrf0214334] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...