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Gene Dmel\Dcr-1

General Information
Symbol	Dmel\Dcr-1	Species	D. melanogaster
Name	Dicer-1	Annotation symbol	CG4792
Feature type	protein_coding_gene	FlyBase ID	FBgn0039016
Gene Model Status	Current	Stock availability	9 publicly available
Also Known As	Dicer, DCR1, dicer1, dicer-1
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	94C4-94C4	Sequence location	3R:18,559,727..18,566,752 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Dicer-1 is referred to in FlyBase by the symbol Dmel\Dcr-1 (CG4792, FBgn0039016). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; bidentate ribonuclease III activity. There is experimental evidence for 11 unique biological process terms, many of which group under: biological regulation; cellular component organization or biogenesis; gene silencing; gene expression; multicellular organism reproduction; multicellular organismal development; gene silencing by miRNA; gamete generation; dsRNA fragmentation; RNA interference. 22 alleles are reported. The phenotypes of these alleles are annotated with: oocyte; embryonic/larval neuromuscular junction. It has one annotated transcript and one annotated polypeptide. Protein features are: Argonaute/Dicer protein, PAZ; Dicer double-stranded RNA-binding fold; Double-stranded RNA-binding; Helicase, C-terminal; Ribonuclease III. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1627580_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Dcr-1. Gene sequence location is 3R:18559727..18566752.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Kibanov et al., 2011, Mol. Biol. Cell 22(18): 3410--3419 Saito et al., 2010, Genes Dev. 24(22): 2493--2498
FB2012_01	References Handler et al., 2011, EMBO J. 30(19): 3977--3993 Thomsen et al., 2010, Genome Biol. 11(9): R93 Tsutsumi et al., 2011, Nat. Struct. Mol. Biol. 18(10): 1153--1158 Sequence features HFA15646 BKN20393
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 94C4-94C4   Limits computationally determined from genome sequence between P{lacW}GclmL0580 and P{EP}hhEP3521
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Dcr-1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Dcr-1-RA FBtr0084324  NM_079729   6854   2249
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Dcr-1-PA   FBpp0083717   255.3   2249   5.47     NP_524453   AAF56056
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ribonuclease III (IPR000999) Double-stranded RNA-binding (IPR001159) Helicase, C-terminal (IPR001650) Argonaute/Dicer protein, PAZ (IPR003100) Dicer double-stranded RNA-binding fold (IPR005034)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA803140   AE014297 AAF56056   AC009846   AI530872   AW944193   AX287266 CAD12300   AY050230 AAK84929   BG637566   CO303120   CO303631   CS456213 CAL91821   DQ398885 ABD61601   DQ398886 ABD61602   DQ398887 ABD61603   DQ398888 ABD61604   DQ398889 ABD61605   DQ398890 ABD61606   DQ398891 ABD61607   DQ398892 ABD61608   EC203082   EC248895   ES693809   ES694018   EY199048
UniProtKB/Swiss-Prot	Q9VCU9
UniProtKB/TrEMBL	Q27IU2 Q27IU3 Q27IU4 Q27IU5 Q27IU6 Q27IU7 Q27IU8 Q27IU9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0039016    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0039016 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0039016 expression level Developmental Stage   Expression Level embryo 00-02hr    1785 embryo 02-04hr    671 embryo 04-06hr    1406 embryo 06-08hr    1297 embryo 08-10hr    973 embryo 10-12hr    586 embryo 12-14hr    570 embryo 14-16hr    452 embryo 16-18hr    267 embryo 18-20hr    188 embryo 20-22hr    163 embryo 22-24hr    164 larva L1    362 larva L2    367 larva L3 12hr old    396 larva L3 puffstage 1-2    337 larva L3 puffstage 3-6    468 larva L3 puffstage 7-9    477 white prepupae new    479 white prepupae 12hr    483 white prepupae 24hr    652 pupae 2d postWPP    350 pupae 3d postWPP    176 pupae 4d postWPP    161 adult male 01day    260 adult male 05day    322 adult male 30day    327 adult female 01day    709 adult female 05day    1132 adult female 30day    1193 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1785) embryo 02-04hr  (671) embryo 04-06hr  (1406) embryo 06-08hr  (1297) embryo 08-10hr  (973) embryo 10-12hr  (586) embryo 12-14hr  (570) embryo 14-16hr  (452) embryo 16-18hr  (267) embryo 18-20hr  (188) embryo 20-22hr  (163) embryo 22-24hr  (164) larva L1  (362) larva L2  (367) larva L3 12hr old  (396) larva L3 puffstage 1-2  (337) larva L3 puffstage 3-6  (468) larva L3 puffstage 7-9  (477) white prepupae new  (479) white prepupae 12hr  (483) white prepupae 24hr  (652) pupae 2d postWPP  (350) pupae 3d postWPP  (176) pupae 4d postWPP  (161) adult male 01day  (260) adult male 05day  (322) adult male 30day  (327) adult female 01day  (709) adult female 05day  (1132) adult female 30day  (1193) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (1785) embryo 02-04hr    671 embryo 04-06hr  1406 embryo 06-08hr    1297 embryo 08-10hr    973 embryo 10-12hr    586 embryo 12-14hr    570 embryo 14-16hr    452 embryo 16-18hr    267 embryo 18-20hr    188 embryo 20-22hr    163 embryo 22-24hr    164 larva L1    362 larva L2    367 larva L3 12hr old    396 larva L3 puffstage 1-2    337 larva L3 puffstage 3-6    468 larva L3 puffstage 7-9    477 white prepupae new    479 white prepupae 12hr    483 white prepupae 24hr    652 pupae 2d postWPP    350 pupae 3d postWPP    176 pupae 4d postWPP    161 adult male 01day    260 adult male 05day    322 adult male 30day    327 adult female 01day    709 adult female 05day    1132 adult female 30day    1193 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1785 embryo 02-04hr    671 embryo 04-06hr    1406 embryo 06-08hr    1297 embryo 08-10hr    973 embryo 10-12hr    586 embryo 12-14hr    570 embryo 14-16hr    452 embryo 16-18hr    267 embryo 18-20hr    188 embryo 20-22hr    163 embryo 22-24hr    164 larva L1    362 larva L2    367 larva L3 12hr old    396 larva L3 puffstage 1-2    337 larva L3 puffstage 3-6    468 larva L3 puffstage 7-9    477 white prepupae new    479 white prepupae 12hr    483 white prepupae 24hr    652 pupae 2d postWPP    350 pupae 3d postWPP    176 pupae 4d postWPP    161 adult male 01day    260 adult male 05day    322 adult male 30day    327 adult female 01day    709 adult female 05day    1132 adult female 30day    1193 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1785 embryo 02-04hr    671 embryo 04-06hr    1406 embryo 06-08hr    1297 embryo 08-10hr    973 embryo 10-12hr    586 embryo 12-14hr    570 embryo 14-16hr    452 embryo 16-18hr    267 embryo 18-20hr    188 embryo 20-22hr    163 embryo 22-24hr    164 larva L1    362 larva L2    367 larva L3 12hr old    396 larva L3 puffstage 1-2    337 larva L3 puffstage 3-6    468 larva L3 puffstage 7-9    477 white prepupae new    479 white prepupae 12hr    483 white prepupae 24hr    652 pupae 2d postWPP    350 pupae 3d postWPP    176 pupae 4d postWPP    161 adult male 01day    260 adult male 05day    322 adult male 30day    327 adult female 01day    709 adult female 05day    1132 adult female 30day    1193 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0039016 expression level Developmental Stage   Expression Level embryo 00-02hr    1785 embryo 02-04hr    671 embryo 04-06hr    1406 embryo 06-08hr    1297 embryo 08-10hr    973 embryo 10-12hr    586 embryo 12-14hr    570 embryo 14-16hr    452 embryo 16-18hr    267 embryo 18-20hr    188 embryo 20-22hr    163 embryo 22-24hr    164 larva L1    362 larva L2    367 larva L3 12hr old    396 larva L3 puffstage 1-2    337 larva L3 puffstage 3-6    468 larva L3 puffstage 7-9    477 white prepupae new    479 white prepupae 12hr    483 white prepupae 24hr    652 pupae 2d postWPP    350 pupae 3d postWPP    176 pupae 4d postWPP    161 adult male 01day    260 adult male 05day    322 adult male 30day    327 adult female 01day    709 adult female 05day    1132 adult female 30day    1193 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1785) embryo 02-04hr  (671) embryo 04-06hr  (1406) embryo 06-08hr  (1297) embryo 08-10hr  (973) embryo 10-12hr  (586) embryo 12-14hr  (570) embryo 14-16hr  (452) embryo 16-18hr  (267) embryo 18-20hr  (188) embryo 20-22hr  (163) embryo 22-24hr  (164) larva L1  (362) larva L2  (367) larva L3 12hr old  (396) larva L3 puffstage 1-2  (337) larva L3 puffstage 3-6  (468) larva L3 puffstage 7-9  (477) white prepupae new  (479) white prepupae 12hr  (483) white prepupae 24hr  (652) pupae 2d postWPP  (350) pupae 3d postWPP  (176) pupae 4d postWPP  (161) adult male 01day  (260) adult male 05day  (322) adult male 30day  (327) adult female 01day  (709) adult female 05day  (1132) adult female 30day  (1193) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  1785 embryo 02-04hr    671 embryo 04-06hr  1406 embryo 06-08hr    1297 embryo 08-10hr    973 embryo 10-12hr    586 embryo 12-14hr    570 embryo 14-16hr    452 embryo 16-18hr    267 embryo 18-20hr    188 embryo 20-22hr    163 embryo 22-24hr    164 larva L1    362 larva L2    367 larva L3 12hr old    396 larva L3 puffstage 1-2    337 larva L3 puffstage 3-6    468 larva L3 puffstage 7-9    477 white prepupae new    479 white prepupae 12hr    483 white prepupae 24hr    652 pupae 2d postWPP    350 pupae 3d postWPP    176 pupae 4d postWPP    161 adult male 01day    260 adult male 05day    322 adult male 30day    327 adult female 01day    709 adult female 05day    1132 adult female 30day    1193 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1785 embryo 02-04hr    671 embryo 04-06hr    1406 embryo 06-08hr    1297 embryo 08-10hr    973 embryo 10-12hr    586 embryo 12-14hr    570 embryo 14-16hr    452 embryo 16-18hr    267 embryo 18-20hr    188 embryo 20-22hr    163 embryo 22-24hr    164 larva L1    362 larva L2    367 larva L3 12hr old    396 larva L3 puffstage 1-2    337 larva L3 puffstage 3-6    468 larva L3 puffstage 7-9    477 white prepupae new    479 white prepupae 12hr    483 white prepupae 24hr    652 pupae 2d postWPP    350 pupae 3d postWPP    176 pupae 4d postWPP    161 adult male 01day    260 adult male 05day    322 adult male 30day    327 adult female 01day    709 adult female 05day    1132 adult female 30day    1193 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1785 embryo 02-04hr    671 embryo 04-06hr    1406 embryo 06-08hr    1297 embryo 08-10hr    973 embryo 10-12hr    586 embryo 12-14hr    570 embryo 14-16hr    452 embryo 16-18hr    267 embryo 18-20hr    188 embryo 20-22hr    163 embryo 22-24hr    164 larva L1    362 larva L2    367 larva L3 12hr old    396 larva L3 puffstage 1-2    337 larva L3 puffstage 3-6    468 larva L3 puffstage 7-9    477 white prepupae new    479 white prepupae 12hr    483 white prepupae 24hr    652 pupae 2d postWPP    350 pupae 3d postWPP    176 pupae 4d postWPP    161 adult male 01day    260 adult male 05day    322 adult male 30day    327 adult female 01day    709 adult female 05day    1132 adult female 30day    1193 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0039016    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0039016 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0039016 expression level Tissue   Expression Level Larval Central Nervous System    92.575 Larval Midgut    31.9 Larval Hindgut    43.4 Larval Malpighian Tubules    37.3 Larval Fat Body    57.5 Larval Salivary Gland    72.9 Larval Trachea    55.95 Larval Carcass    46.775 Adult Head    33 Adult Eye    21.55 Adult Brain    41 Adult Thoracic-Abdominal Ganglion    35.9 Adult Crop    33.9 Adult Midgut    32.8 Adult Hindgut    34.3 Adult Malpighian Tubules    33.7 Adult Fat Body    48 Adult Salivary Gland no informative data Adult Heart    22.3 Adult VirginFemale Spermatheca    65.4 Adult InseminatedFemale Spermatheca    55.7 Adult Ovary    108.7 Adult Testis    36.2 Adult Male Accessory Gland    54.7 Adult Carcass    37.2 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    92.575 Larval Midgut    31.9 Larval Hindgut    43.4 Larval Malpighian Tubules    37.3 Larval Fat Body    57.5 Larval Salivary Gland    72.9 Larval Trachea    55.95 Larval Carcass    46.775 Adult Head    33 Adult Eye    21.55 Adult Brain    41 Adult Thoracic-Abdominal Ganglion    35.9 Adult Crop    33.9 Adult Midgut    32.8 Adult Hindgut    34.3 Adult Malpighian Tubules    33.7 Adult Fat Body    48 Adult Salivary Gland no informative data Adult Heart    22.3 Adult VirginFemale Spermatheca    65.4 Adult InseminatedFemale Spermatheca    55.7 Adult Ovary    108.7 Adult Testis    36.2 Adult Male Accessory Gland    54.7 Adult Carcass    37.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    92.575 Larval Midgut    31.9 Larval Hindgut    43.4 Larval Malpighian Tubules    37.3 Larval Fat Body    57.5 Larval Salivary Gland    72.9 Larval Trachea    55.95 Larval Carcass    46.775 Adult Head    33 Adult Eye    21.55 Adult Brain    41 Adult Thoracic-Abdominal Ganglion    35.9 Adult Crop    33.9 Adult Midgut    32.8 Adult Hindgut    34.3 Adult Malpighian Tubules    33.7 Adult Fat Body    48 Adult Salivary Gland no informative data Adult Heart    22.3 Adult VirginFemale Spermatheca    65.4 Adult InseminatedFemale Spermatheca    55.7 Adult Ovary    108.7 Adult Testis    36.2 Adult Male Accessory Gland    54.7 Adult Carcass    37.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    92.575 Larval Midgut    31.9 Larval Hindgut    43.4 Larval Malpighian Tubules    37.3 Larval Fat Body    57.5 Larval Salivary Gland    72.9 Larval Trachea    55.95 Larval Carcass    46.775 Adult Head    33 Adult Eye    21.55 Adult Brain    41 Adult Thoracic-Abdominal Ganglion    35.9 Adult Crop    33.9 Adult Midgut    32.8 Adult Hindgut    34.3 Adult Malpighian Tubules    33.7 Adult Fat Body    48 Adult Salivary Gland no informative data Adult Heart    22.3 Adult VirginFemale Spermatheca    65.4 Adult InseminatedFemale Spermatheca    55.7 Adult Ovary    108.7 Adult Testis    36.2 Adult Male Accessory Gland    54.7 Adult Carcass    37.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0039016 expression level Tissue   Expression Level Larval Central Nervous System    92.575 Larval Midgut    31.9 Larval Hindgut    43.4 Larval Malpighian Tubules    37.3 Larval Fat Body    57.5 Larval Salivary Gland    72.9 Larval Trachea    55.95 Larval Carcass    46.775 Adult Head    33 Adult Eye    21.55 Adult Brain    41 Adult Thoracic-Abdominal Ganglion    35.9 Adult Crop    33.9 Adult Midgut    32.8 Adult Hindgut    34.3 Adult Malpighian Tubules    33.7 Adult Fat Body    48 Adult Salivary Gland no informative data Adult Heart    22.3 Adult VirginFemale Spermatheca    65.4 Adult InseminatedFemale Spermatheca    55.7 Adult Ovary    108.7 Adult Testis    36.2 Adult Male Accessory Gland    54.7 Adult Carcass    37.2 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    92.575 Larval Midgut    31.9 Larval Hindgut    43.4 Larval Malpighian Tubules    37.3 Larval Fat Body    57.5 Larval Salivary Gland    72.9 Larval Trachea    55.95 Larval Carcass    46.775 Adult Head    33 Adult Eye    21.55 Adult Brain    41 Adult Thoracic-Abdominal Ganglion    35.9 Adult Crop    33.9 Adult Midgut    32.8 Adult Hindgut    34.3 Adult Malpighian Tubules    33.7 Adult Fat Body    48 Adult Salivary Gland no informative data Adult Heart    22.3 Adult VirginFemale Spermatheca    65.4 Adult InseminatedFemale Spermatheca    55.7 Adult Ovary    108.7 Adult Testis    36.2 Adult Male Accessory Gland    54.7 Adult Carcass    37.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    92.575 Larval Midgut    31.9 Larval Hindgut    43.4 Larval Malpighian Tubules    37.3 Larval Fat Body    57.5 Larval Salivary Gland    72.9 Larval Trachea    55.95 Larval Carcass    46.775 Adult Head    33 Adult Eye    21.55 Adult Brain    41 Adult Thoracic-Abdominal Ganglion    35.9 Adult Crop    33.9 Adult Midgut    32.8 Adult Hindgut    34.3 Adult Malpighian Tubules    33.7 Adult Fat Body    48 Adult Salivary Gland no informative data Adult Heart    22.3 Adult VirginFemale Spermatheca    65.4 Adult InseminatedFemale Spermatheca    55.7 Adult Ovary    108.7 Adult Testis    36.2 Adult Male Accessory Gland    54.7 Adult Carcass    37.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    92.575 Larval Midgut    31.9 Larval Hindgut    43.4 Larval Malpighian Tubules    37.3 Larval Fat Body    57.5 Larval Salivary Gland    72.9 Larval Trachea    55.95 Larval Carcass    46.775 Adult Head    33 Adult Eye    21.55 Adult Brain    41 Adult Thoracic-Abdominal Ganglion    35.9 Adult Crop    33.9 Adult Midgut    32.8 Adult Hindgut    34.3 Adult Malpighian Tubules    33.7 Adult Fat Body    48 Adult Salivary Gland no informative data Adult Heart    22.3 Adult VirginFemale Spermatheca    65.4 Adult InseminatedFemale Spermatheca    55.7 Adult Ovary    108.7 Adult Testis    36.2 Adult Male Accessory Gland    54.7 Adult Carcass    37.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    33   NA  Eye    21.55   NA  Brain    41   92.575  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    35.9   NA  Crop    33.9   31.9  Midgut    32.8   43.4  Hindgut    34.3   37.3  Malpighian Tubules    33.7   57.5  Fat Body    48   72.9  Salivary Gland    no informative data   NA  Heart    22.3   55.95  Trachea    NA   NA  VirginFemale Spermatheca    65.4   NA  InseminatedFemale Spermatheca    55.7   NA  Ovary    108.7   NA  Testis    36.2   NA  Male Accessory Gland    54.7   46.775  Carcass    37.2 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039016 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4792-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage, with Scer\GAL4αTub84B.PL Dcr-1dsRNA.Scer\UAS.WIZ lethal | embryonic stage | recessive Dcr-1Q1147X lethal | recessive Dcr-1Q1147X viable, with Scer\GAL4pnr-MD237 Dcr-1GD11429 Other Phenotypes Allele increased cell death | somatic clone Dcr-1Q1147X mitotic cell cycle defective | embryonic stage Dcr-1Q1147X neuroanatomy defective | somatic clone Dcr-1LL06357 Dcr-1Q1147X Dcr-1Q1948X suppressor of variegation, with P{T1(-FRT)}T190-177 Dcr-1Q1147X suppressor of variegation, with P{T1}T190-177 Dcr-1Q1147X visible | somatic clone Dcr-1Q1147X Phenotype manifest in Allele abdominal 1 dorsal multidendritic neuron ddaC | somatic clone Dcr-1Q1147X Dcr-1Q1948X adult antennal lobe projection neuron DL1 adPN | somatic clone Dcr-1LL06357 antennal lobe projection neuron adPN | somatic clone Dcr-1LL06357 antennal lobe projection neuron lPN | somatic clone Dcr-1LL06357 axon & DL1 adPN | somatic clone Dcr-1LL06357 chaeta & mesothoracic tergum | somatic clone Dcr-1Q1147X dendrite & ad PN | somatic clone Dcr-1LL06357 dendrite & DA1 lPN | somatic clone Dcr-1LL06357 dendrite & DL1 adPN | somatic clone Dcr-1LL06357 dendrite & lPN | somatic clone Dcr-1LL06357 dendrite & vPN | somatic clone Dcr-1LL06357 dendrite | somatic clone Dcr-1Q1147X Dcr-1Q1948X embryonic/larval neuromuscular junction, with Scer\GAL4how-24B Dcr-1dsRNA.Scer\UAS.WIZ eye | somatic clone Dcr-1Q1147X eye disc | somatic clone Dcr-1Q1147X germline stem cell | germline clone Dcr-1Q1147X Dcr-1Q1948X oocyte Dcr-1Q1147X ovariole | germline clone Dcr-1Q1147X Dcr-1Q1948X pole cell | germline clone | maternal effect Dcr-1Q1147X wing | somatic clone Dcr-1Q1147X wing disc | somatic clone Dcr-1Q1147X
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of Dcr-1 Class Mutagen Stocks Known lesion Dcr-1LL06357 1 Yes Dcr-1Q1147X ethyl methanesulfonate 1 Yes Dcr-1Q1948X 1 --
Alleles Carried on Transgenic Constructs ( 19 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Dcr-1 Class Mutagen Stocks Known lesion Dcr-1GD11429 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Dcr-1HM05086 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Dcr-1HMS00141 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Dcr-1KK100297 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Dcr-1Scer\UAS.cDa in vitro construct - regulatory fusion 1 Yes Dcr-1dsRNA.5912-6737 in vitro construct - RNAi 0 Yes Dcr-1dsRNA.cBa in vitro construct - RNAi 0 Yes Dcr-1dsRNA.cDa in vitro construct - RNAi 0 Yes Dcr-1dsRNA.cFa in vitro construct - RNAi 0 Yes Dcr-1dsRNA.cJa in vitro construct - RNAi 0 Yes Dcr-1dsRNA.cJb in vitro construct - RNAi 0 Yes Dcr-1dsRNA.cLa in vitro construct - RNAi 0 Yes Dcr-1dsRNA.cOa in vitro construct - RNAi 0 Yes Dcr-1dsRNA.cRa in vitro construct - RNAi 0 Yes Dcr-1dsRNA.cSa in vitro construct - RNAi 0 Yes Dcr-1dsRNA.Scer\UAS.WIZ in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes Dcr-1MtnA.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Dcr-1T:Uuuu\T7 in vitro construct - coding region fusion 0 Yes Dcr-1VDRC.cUa in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6192 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11429} NA P{KK100297} NA P{TRiP.HM05086} NA P{TRiP.HMS00141} NA P{UAS-Dcr-1.D} NA P{UAS-Dcr-1.WIZ} NA characterization construct P{VDRC.Dcr-1.U} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{SAstopDsRed}Dcr-1LL06357 NA
Gene Ontology: Function, Process & Cellular Component ( 20 unique terms )
Terms Based on Experimental Evidence ( 16 terms )
Molecular Function
CV term Evidence References
bidentate ribonuclease III activity inferred from direct assay (Bernstein et al., 2001) protein binding inferred from physical interaction with AGO1 (Okamura et al., 2004) inferred from physical interaction with AGO2 (Hammond et al., 2001) inferred from physical interaction with Fmr1 (assigned by UniProtKB) (Ishizuka et al., 2002) inferred from physical interaction with loqs (Ye et al., 2007) inferred from physical interaction with piwi (Megosh et al., 2006) inferred from physical interaction with vas (Megosh et al., 2006)
Biological Process
CV term Evidence References
dendrite morphogenesis inferred from mutant phenotype (Berdnik et al., 2008) dsRNA transport inferred from mutant phenotype (Saleh et al., 2006) germ-line stem cell division inferred from mutant phenotype (Hatfield et al., 2005) mitotic cell cycle, embryonic inferred from mutant phenotype (Megosh et al., 2006) pole cell formation inferred from mutant phenotype (Megosh et al., 2006) pre-miRNA processing inferred from direct assay (Ye et al., 2007) inferred from mutant phenotype (Jiang et al., 2005, Forstemann et al., 2005, Saito et al., 2005) production of miRNAs involved in gene silencing by miRNA inferred from mutant phenotype (Lee et al., 2004) production of siRNA involved in RNA interference inferred from direct assay (Bernstein et al., 2001) inferred from direct assay (assigned by UniProtKB) (Ishizuka et al., 2002) RNA interference inferred from direct assay (Pham et al., 2004) inferred from mutant phenotype (Lee et al., 2004) segment polarity determination inferred from genetic interaction with AGO1 (Meyer et al., 2006) siRNA loading onto RISC involved in RNA interference inferred from mutant phenotype (Lee et al., 2004)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (Saito et al., 2005, Grimaud et al., 2006) colocalizes_with nucleus inferred from direct assay (Grimaud et al., 2006) RNA-induced silencing complex inferred from direct assay (Pham et al., 2004)
Terms Based on Predictions or Assertions ( 7 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR001650 (FlyBase Curators et al., 2004-) double-stranded RNA binding inferred from electronic annotation with InterPro:IPR001159 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Lasko, 2000) helicase activity inferred from electronic annotation with InterPro:IPR001650 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
gene silencing by miRNA traceable author statement (Heinrichs, 2004) pre-miRNA processing traceable author statement (He and Hannon, 2004) production of miRNAs involved in gene silencing by miRNA traceable author statement (Heinrichs, 2004, Skipper, 2004) RNA interference traceable author statement (Cerutti, 2003, Heinrichs, 2004)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Dcr-1 allele Gene References Dcr-1Q1147X dap (Hatfield et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67642 DroID - A comprehensive database of gene and protein interactions. • FBgn0039016 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42693
Orthologs
Genome-wide drosophilid orthologs	Dana\GF18290 Dere\GG12488 Dgri\GH18503 Dmoj\GI24348 Dper\GL23778 Dpse\GA18437 Dsec\GM23619 Dvir\GJ24359 Dwil\GK11626 Dyak\GE24009
Curated drosophilid orthologs	Dpse\GA18437   Dsim\Dcr-1 (Obbard et al., 2006.2.10)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL001612-PA Aedes aegypti (mosquito) AGAP002836-PA Anopheles gambiae (mosquito) XP_624510.2 Apis mellifera (honey bee) XP_001944314.1 Acyrthosiphon pisum (pea aphid) At1g01040.1 Arabidopsis thaliana (wall cress) 23044 Batrachochytrium dendrobatidis (chytrid fungus) 202604 Branchiostoma floridae (lancelet) 244760 Branchiostoma floridae (lancelet) ENSBTAP00000051463 Bos taurus (bovine) CN04613 Caenorhabditis brenneri (small nematode) CBP29718 Caenorhabditis briggsae (nematode) CE25057 Caenorhabditis elegans (worm) ENSCAFP00000026121 Canis familiaris (dog) ENSCINP00000017117 Ciona intestinalis (sea squirt) JA11476 Caenorhabditis japonica (nematode) cn03359 Cryptococcus neoformans (yeast-like fungus) CPIJ003169 Culex pipens (mosquito) ENSCPOP00000003807 Cavia porcellus (guinea pig) RP31780 Caenorhabditis remanei (nematode) ENSCSAVP00000010413 Ciona savignyi (sedentary tunicate) 223153 Capitella spl (polychaete worm) 308316 Daphnia pulex (daphnia) ENSDARP00000045880 Danio rerio (zebra fish) ENSECAP00000005352 Equus caballus (horse) ENSGACP00000026600 Gymnopilus aculeatus (mushroom) ENSGALP00000017889 Gallus gallus (chicken) 103772 Hypsipyla robusta (cedar shoot borer) ENSP00000376783 Homo sapiens (human) ISCW000890-PA Ixodes scapularis (deer tick) 111015 Lottia gigantea (owl limpet) ENSMODP00000015796 Monodelphis domestica (gray opossum) ENSMMUP00000032603 Macaca mulatta (rhesus monkey) ENSMUSP00000043676 Mus musculus (house mouse) XP_001605287.1 Nasonia vitripennis (wasp) ENSOANP00000019062 Ornithorynchus anatinus (platypus) ENSORLP00000013824 Oryzias latipes (japanese killifish) LOC_Os03g02970.1 Oryza sativa (asian rice) PHUM002435-PA Pediculus humanus (human body louse) 205895 Physcomitrella patens (moss) ENSPPYP00000006949 Pongo pygmaeus (orangutan) 158151 Phytophthora sojae (root rot pathogen) 552372 Populus trichocarpa (black cottonwood) ENSPTRP00000046628 Pan troglodytes (chimpanzee) ENSRNOP00000014405 Rattus norvegicus (norway rat) 4999016 Sorghum bicolor (sorghum) Smp_169750 Schistosoma mansoni (trematode parasite) XP_790894.1 Strongylocentrotus purpuratus (purple sea urchin) 51673 Trichoplax adhaerens (metazoa) XP_968993.2 Tribolium castaneum (red flour beetle) ENSTNIP00000008130 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000014961 Takifugu rubripes (pufferfish Takifugu) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV18057 LH14175 ISCW000890 FBgn0241151 FBgn0213637 FBgn0211439 FBgn0084784 FBgn0178484 JGI_V11_308316 FBgn0078439 FBgn0161368 FBgn0147071 FBgn0125970 FBgn0104776 FBgn0095308 CPIJ003169 BGIBMGA001833 ACYPI005290 ACYPI000864 GB11966 AGAP002836 AAEL001612 PB22137 PHUM435060 GLEAN_01750
Stocks & Reagents
Stocks Listed in FlyBase ( 9 )
Bloomington	36510 y1 w*; P{UAS-Dcr-1.D}3 34826 y1 sc* v1; P{TRiP.HMS00141}attP2 28598 y1 v1; P{TRiP.HM05086}attP2/TM3, Sb1 32067 P{GMR-w.IR}13D; P{neoFRT}82B Dcr-1Q1948X/TM3, Sb1 32066 yd2 w1118 P{ey-FLP.N}2; P{neoFRT}82B Dcr-1Q1147X/TM3, Sb1
Kyoto	141894 y* w*; P{FRT(whs)}2A P{neoFRT}82B PBac{SAstopDsRed}Dcr-1LL06357 P{Car20y}96E / TM6B, Tb1
VDRC	v106041 P{KK100297}VIE-260B v24666 w1118; P{GD11429}v24666 v24667 w1118; P{GD11429}v24667
Genomic Clones ( 1 )
	BACR23F10 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 5 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	SD01621
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	120298 EK240052 EK242252 GM10303
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0039016 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42693
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Dcr-1 CG4792 (Bernstein et al., 2001)
Source for database merge of
Additional comments
Other Comments
	The loqs-PD isoform is capable of associating with the Dcr-2 protein, but not with the Dcr-1 protein. The loqs-PB and loqs-PA isoforms can associate with the Dcr-1 protein, and also to some extent with Dcr-2 protein. (Hartig et al., 2009) The loqs-PB isoform, and to a lesser extent the loqs-PA isoform, is capable of associating with the Dcr-1 protein. The loqs-PD isoform is capable of associating with the Dcr-2 protein, but not with the Dcr-1 protein. (Zhou et al., 2009) Dcr-1 is required for normal projection neuron dendrite targeting and axon-terminal elaboration. (Berdnik et al., 2008) Expression is not enriched in embryonic gonads. (Shigenobu et al., 2006) Dcr-1 is not required for repeat-associated small interfering RNA (rasiRNA) production (Vagin et al., 2006) loqs is required together with Dcr-1 for normal pre-miRNA processing. (Forstemann et al., 2005) loqs protein alone is not capable of converting pre-miRNAs into mature miRNAs. However, the loqs and Dcr-1 proteins form a complex that converts pre-miRNAs into mature miRNAs, and the loqs protein stimulates and directs the specific pre-miRNA processing activity of Dcr-1 protein. (Saito et al., 2005)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079729 RefSeq (Proteins) • NP_524453 DDBJ / EMBL / GenBank • AAF56056 AAK84929 ABD61601 ABD61602 ABD61603 ABD61604 ABD61605 ABD61606 ABD61607 ABD61608 AC009846 AI530872 AW944193 AX287266 AY050230 CAD12300 CAL91821 CS456213 DQ398885 DQ398886 DQ398887 DQ398888 DQ398889 DQ398890 DQ398891 DQ398892 Entrez Gene - A searchable database of RefSeq genes. • 42693 UniProtKB/Swiss-Prot • Q9VCU9 UniProtKB/TrEMBL • Q27IU2 Q27IU3 Q27IU4 Q27IU5 Q27IU6 Q27IU7 Q27IU8 Q27IU9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ribonuclease III (IPR000999) Double-stranded RNA-binding (IPR001159) Helicase, C-terminal (IPR001650) Argonaute/Dicer protein, PAZ (IPR003100) Dicer double-stranded RNA-binding fold (IPR005034)
Linkouts
	BioGRID - A database of protein and genetic interactions • 67642 DroID - A comprehensive database of gene and protein interactions. • FBgn0039016 DRSC - Results from RNAi screens. • FBgn0039016 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039016 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4792-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0039016 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42693 InParanoid A subset of ortholog calls from InParanoid. • AAEL001612-PA Aedes aegypti (mosquito) AGAP002836-PA Anopheles gambiae (mosquito) XP_624510.2 Apis mellifera (honey bee) XP_001944314.1 Acyrthosiphon pisum (pea aphid) At1g01040.1 Arabidopsis thaliana (wall cress) 23044 Batrachochytrium dendrobatidis (chytrid fungus) 202604 Branchiostoma floridae (lancelet) 244760 Branchiostoma floridae (lancelet) ENSBTAP00000051463 Bos taurus (bovine) CN04613 Caenorhabditis brenneri (small nematode) CBP29718 Caenorhabditis briggsae (nematode) CE25057 Caenorhabditis elegans (worm) ENSCAFP00000026121 Canis familiaris (dog) ENSCINP00000017117 Ciona intestinalis (sea squirt) JA11476 Caenorhabditis japonica (nematode) cn03359 Cryptococcus neoformans (yeast-like fungus) CPIJ003169 Culex pipens (mosquito) ENSCPOP00000003807 Cavia porcellus (guinea pig) RP31780 Caenorhabditis remanei (nematode) ENSCSAVP00000010413 Ciona savignyi (sedentary tunicate) 223153 Capitella spl (polychaete worm) 308316 Daphnia pulex (daphnia) ENSDARP00000045880 Danio rerio (zebra fish) ENSECAP00000005352 Equus caballus (horse) ENSGACP00000026600 Gymnopilus aculeatus (mushroom) ENSGALP00000017889 Gallus gallus (chicken) 103772 Hypsipyla robusta (cedar shoot borer) ENSP00000376783 Homo sapiens (human) ISCW000890-PA Ixodes scapularis (deer tick) 111015 Lottia gigantea (owl limpet) ENSMODP00000015796 Monodelphis domestica (gray opossum) ENSMMUP00000032603 Macaca mulatta (rhesus monkey) ENSMUSP00000043676 Mus musculus (house mouse) XP_001605287.1 Nasonia vitripennis (wasp) ENSOANP00000019062 Ornithorynchus anatinus (platypus) ENSORLP00000013824 Oryzias latipes (japanese killifish) LOC_Os03g02970.1 Oryza sativa (asian rice) PHUM002435-PA Pediculus humanus (human body louse) 205895 Physcomitrella patens (moss) ENSPPYP00000006949 Pongo pygmaeus (orangutan) 158151 Phytophthora sojae (root rot pathogen) 552372 Populus trichocarpa (black cottonwood) ENSPTRP00000046628 Pan troglodytes (chimpanzee) ENSRNOP00000014405 Rattus norvegicus (norway rat) 4999016 Sorghum bicolor (sorghum) Smp_169750 Schistosoma mansoni (trematode parasite) XP_790894.1 Strongylocentrotus purpuratus (purple sea urchin) 51673 Trichoplax adhaerens (metazoa) XP_968993.2 Tribolium castaneum (red flour beetle) ENSTNIP00000008130 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000014961 Takifugu rubripes (pufferfish Takifugu) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /dbzhnsky/dicer1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42693 modMine - Data generated by the modENCODE project. • FBgn0039016 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV18057 LH14175 ISCW000890 FBgn0241151 FBgn0213637 FBgn0211439 FBgn0084784 FBgn0178484 JGI_V11_308316 FBgn0078439 FBgn0161368 FBgn0147071 FBgn0125970 FBgn0104776 FBgn0095308 CPIJ003169 BGIBMGA001833 ACYPI005290 ACYPI000864 GB11966 AGAP002836 AAEL001612 PB22137 PHUM435060 GLEAN_01750
Synonyms & Secondary IDs ( 17 )
Reported As
Symbol Synonym	CG4792 (Hammond, 2005, Cerutti et al., 2000, Anantharaman et al., 2002, Bernstein et al., 2001, Saleh et al., 2006, Keleman et al., 2009.8.5, Perkins et al., 2009, Ni et al., 2011.7.19) cg4792 (Lasko, 2000) Dcr (Kadener et al., 2009) Dcr-1 (Czech et al., 2008, Park et al., 2007, Grimaud et al., 2006, Dorner et al., 2006, Shigenobu et al., 2006, Meyer et al., 2006, Okamura et al., 2009, Okamura et al., 2007, Tomari et al., 2007, Jin and Xie, 2008, Dietzl et al., 2007, Ye et al., 2007, Okamura et al., 2008, Preall et al., 2006, Chung et al., 2008, Zhou et al., 2008, Karr et al., 2009, Yu et al., 2009, Habayeb et al., 2009, Sabin et al., 2009, Liu et al., 2007, Lipardi and Paterson, 2009, Zhou et al., 2009, Carthew, 2010.7.27, Mukherjee and Hanley, 2010, Ghildiyal et al., 2010, Okamura et al., 2011, Wasbrough et al., 2010, Cenik et al., 2011, Poulton et al., 2011, Kawamata et al., 2009) dcr-1 (Friggi-Grelin et al., 2008, Forstemann et al., 2005, Hatfield et al., 2005, Heinrichs, 2004, Du et al., 2006, Megosh et al., 2006, Lim and Kai, 2007, Hartig et al., 2009, Haynes et al., 2006, Kavi et al., 2006, Förstemann et al., 2007, Bilen et al., 2006, Ghildiyal et al., 2008, Jin and Xie, 2007, Park et al., 2007, Lim and Kai, 2007, Xu et al., 2008, Kadener et al., 2009, Flynt et al., 2009, Pek et al., 2009, Martin et al., 2009, Kalidas et al., 2008, Lee et al., 2009, Czech et al., 2009, Bejarano et al., 2010, Herranz et al., 2010, Gehrke et al., 2010) DCR1 (Tang, 2005, Matzke and Birchler, 2005, Eulalio et al., 2007) dcr1 (Hatfield et al., 2005, Chambeyron et al., 2008, Cziko et al., 2009) Dcr1 (Obbard et al., 2006.2.10, Obbard et al., 2006, Brodersen and Voinnet, 2006, Zaratiegui, 2007, Kawamura et al., 2008) dcr 1 (Kadener et al., 2009) Dicer (Zhang and Broadie, 2005, Finnegan and Matzke, 2003, Chekulaeva and Ephrussi, 2004, Hutvagner and Zamore, 2002, Cerutti, 2003, Findley et al., 2003, Carmell et al., 2002, Ishizuka et al., 2002, Pasquinelli, 2002, Zamore, 2002, Hannon, 2002, Schwarz and Zamore, 2002, Matzke et al., 2001, Ruvkun, 2001, Moss, 2001, Hammond et al., 2001, Bernstein et al., 2001, Pearson et al., 2005, Yu et al., 2007, Schwarz et al., 2002) dicer (Denli and Hannon, 2003, Elbashir et al., 2001, Tsang, 2001, Baulcombe, 2001) DICER (Lakatos et al., 2004) dicer-1 (Croce, 2005, Nakahara and Carthew, 2004, Heinrichs, 2004) dicer1 (Meyer et al., 2005, Hatfield et al., 2005) Dicer1 (Megosh et al., 2005, Carmell and Hannon, 2004)
Name Synonym	Dicer (Stitzel and Seydoux, 2007, Schmittgen et al., 2004, Yu et al., 2007, Carthew, 2006, Schwarz et al., 2002, Glavic et al., 2009, Celotto and Graveley, 2002, Bejarano et al., 2010, Lee et al., 2011) dicer (Kavi et al., 2006, Horabin and Olcese, 2008, Benítez et al., 2009) Dicer1 (Landthaler et al., 2004, Siomi et al., 2005, Ghildiyal et al., 2010, Miyoshi et al., 2010) Dicer-1 (Bernstein et al., 2001, Carmi, 2006, Vagin et al., 2006, Seydoux and Braun, 2006, Shcherbata et al., 2007, LeBrasseur, 2005, Lin, 2007, Jin and Xie, 2008, Shcherbata et al., 2008, Reynolds et al., 2008, Jacquier et al., 2008, Eulalio et al., 2007, Rehwinkel et al., 2006, Czech et al., 2008, Jin and Xie, 2007, Park et al., 2007, Berdnik et al., 2008, Saleh et al., 2006, Eulalio et al., 2007, Karr et al., 2009, Yu et al., 2009, Li et al., 2009, Liu et al., 2007, Berdnik et al., 2008, Zhou et al., 2009, Herranz et al., 2010, Flynt et al., 2010, Gangaraju et al., 2011, Cenik et al., 2011, Poulton et al., 2011, Ni et al., 2011, Park et al., 2011) DICER-1 (Megosh et al., 2006) dicer-1 (Ruby et al., 2007, Garcia et al., 2007, Ruby et al., 2007, Yu et al., 2008, Bilen et al., 2006, Kadener et al., 2009, Pek et al., 2009, Kadener et al., 2009, Kalidas et al., 2008, Lee et al., 2009, Xu et al., 2008, Gehrke et al., 2010, Thomsen et al., 2010) dicer1 (Gehrke et al., 2010, Saito et al., 2010, Handler et al., 2011)
Secondary FlyBase IDs
References ( 193 )
Generate a list of	All references relating to this gene ( 193 )
List References by type	Research paper  ( 103 ) Supplementary material  ( 6 ) Review  ( 51 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 15 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 3 ) Conference report  ( 1 ) Patent  ( 1 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 19 )
	Cenik et al., 2011, Mol. Cell 42(2): 172--184 Phosphate and R2D2 Restrict the Substrate Specificity of Dicer-2, an ATP-Driven Ribonuclease. [FBrf0213543] Gangaraju et al., 2011, Nat. Genet. 43(2): 153--158 Drosophila Piwi functions in Hsp90-mediated suppression of phenotypic variation. [FBrf0212873] Handler et al., 2011, EMBO J. 30(19): 3977--3993 A systematic analysis of Drosophila TUDOR domain-containing proteins identifies Vreteno and the Tdrd12 family as essential primary piRNA pathway factors. [FBrf0216344] Kibanov et al., 2011, Mol. Biol. Cell 22(18): 3410--3419 A novel organelle, the piNG-body, in the nuage of Drosophila male germ cells is associated with piRNA-mediated gene silencing. [FBrf0215572] Lee et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(33): 13794--13799 Serotonin-mushroom body circuit modulating the formation of anesthesia-resistant memory in Drosophila. [FBrf0214737] Ni et al., 2011, Nat. Methods 8(5): 405--407 A genome-scale shRNA resource for transgenic RNAi in Drosophila. [FBrf0213581] Okamura et al., 2011, Mol. Cell. Biol. 31(4): 884--896 R2D2 Organizes Small Regulatory RNA Pathways in Drosophila. [FBrf0212879] Park et al., 2011, Nature 475(7355): 201--205 Dicer recognizes the 5' end of RNA for efficient and accurate processing. [FBrf0214413] Poulton et al., 2011, Development 138(9): 1737--1745 The microRNA pathway regulates the temporal pattern of Notch signaling in Drosophila follicle cells. [FBrf0213494] Tsutsumi et al., 2011, Nat. Struct. Mol. Biol. 18(10): 1153--1158 Recognition of the pre-miRNA structure by Drosophila Dicer-1. [FBrf0216328] Bejarano et al., 2010, Dev. Biol. 338(1): 63--73 miR-9a prevents apoptosis during wing development by repressing Drosophila LIM-only. [FBrf0209786] Flynt et al., 2010, Mol. Cell 38(6): 900--907 MicroRNA Biogenesis via Splicing and Exosome-Mediated Trimming in Drosophila. [FBrf0211240] Gehrke et al., 2010, Nature 466(7306): 637--641 Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression. [FBrf0211387] Ghildiyal et al., 2010, RNA 16(1): 43--56 Sorting of Drosophila small silencing RNAs partitions microRNA* strands into the RNA interference pathway. [FBrf0209572] Herranz et al., 2010, EMBO J. 29(10): 1688--1698 The miRNA machinery targets Mei-P26 and regulates Myc protein levels in the Drosophila wing. [FBrf0210816] Miyoshi et al., 2010, RNA 16(3): 506--515 Molecular mechanisms that funnel RNA precursors into endogenous small-interfering RNA and microRNA biogenesis pathways in Drosophila. [FBrf0210024] Mukherjee and Hanley, 2010, BMC Microbiol. 10: 127 RNA interference modulates replication of dengue virus in Drosophila melanogaster cells. [FBrf0210847] Saito et al., 2010, Genes Dev. 24(22): 2493--2498 Roles for the Yb body components Armitage and Yb in primary piRNA biogenesis in Drosophila. [FBrf0212297] Thomsen et al., 2010, Genome Biol. 11(9): R93 Genome-wide analysis of mRNA decay patterns during early Drosophila development. [FBrf0212195] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...