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Gene Dmel\HP1c

General Information
Symbol	Dmel\HP1c	Species	D. melanogaster
Name	HP1c	Annotation symbol	CG6990
Feature type	protein_coding_gene	FlyBase ID	FBgn0039019
Gene Model Status	Current	Stock availability	8 publicly available
Also Known As	HP1
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	94C4-94C4	Sequence location	3R:18,571,350..18,572,327 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene HP1c is referred to in FlyBase by the symbol Dmel\HP1c (CG6990, FBgn0039019). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; chromatin binding; methylated histone residue binding. There is experimental evidence that it is involved in the biological process: positive regulation of chromatin silencing at telomere; regulation of transcription from RNA polymerase II promoter. 13 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Chromo domain; Chromo domain subgroup; Chromo domain, conserved site; Chromo domain-like; Chromo domain/shadow; Chromo shadow domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, adult hindgut, larval/adult Malpighian tubules, larval fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system. Comments on Affy2 ProbeSet: ProbeSet 1629470_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of HP1c. Gene sequence location is 3R:18571350..18572327.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 94C4-94C4   Limits computationally determined from genome sequence between P{lacW}GclmL0580 and P{EP}hhEP3521
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\HP1c for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.42
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) HP1c-RA FBtr0084309  NM_142836   978   237
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein HP1c-PA   FBpp0083702   26.7   237   4.70     NP_651093   AAF56059
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Chromo domain subgroup (IPR017984) Chromo domain/shadow (IPR000953) Chromo shadow domain (IPR008251) Chromo domain-like (IPR016197) Chromo domain, conserved site (IPR023779) Chromo domain (IPR023780)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA391289   AA820321   AA951095   AE014297 AAF56059   AI259775   AI386783   AW942691   AY061322 AAL28870   BG638550   BI229504   BI232390   BI232750   BI612479   BP556950   BP556951   CO178954   CO308697   CZ487515   EC238252   EV594648   EV596888   GH750070   GH750407   GH751853   GH752018   GH752458   GH756507   GH757264   GH757693   GH758206   GH771815   GH772030   GH773591   GH778934   GH779518   GH780259   GH780691   GH781848   GH782538   GH785250   GH786790   GH795089   GH804444   GH808480   GH812763   GH815643   GH816695   GH819181   GH823694   GH831386   GH832662   GH836513   GH837213   GH839255   GH842272   GH846202   GH848450   GH849522   GH853586   GH861656   GH867507   GH868176   GH869806   GH878244   GH878590   GH879709   GH885114   GH885967   GH888236   GH897864   GH898325   GH905490   GH906440   GH911809   GH916522   GH918096   GH922530   GH922789   GH933626   GH935646   GH942527
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VCU6
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   central brain primordium   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic/larval nervous system   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
colocalizes_with euchromatin inferred from direct assay (Font-Burgada et al., 2008) nucleus inferred from direct assay (Font-Burgada et al., 2008) polytene chromosome interband inferred from direct assay (Font-Burgada et al., 2008, Abel et al., 2009) protein complex inferred from direct assay (Abel et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, adult hindgut, larval/adult Malpighian tubules, larval fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    309.3 Larval Midgut    56.9 Larval Hindgut    86.9 Larval Malpighian Tubules    101.9 Larval Fat Body    138.3 Larval Salivary Gland    160.6 Larval Trachea    153.275 Larval Carcass    85.775 Adult Head    122.8 Adult Eye    182.225 Adult Brain    163.3 Adult Thoracic-Abdominal Ganglion    121.2 Adult Crop    115 Adult Midgut    73.2 Adult Hindgut    112.4 Adult Malpighian Tubules    109.6 Adult Fat Body    54.6 Adult Salivary Gland    127.1 Adult Heart    50.9 Adult VirginFemale Spermatheca    109 Adult InseminatedFemale Spermatheca    126.4 Adult Ovary    293.5 Adult Testis    147.7 Adult Male Accessory Gland    211.9 Adult Carcass    73.1 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    309.3 Larval Midgut    56.9 Larval Hindgut    86.9 Larval Malpighian Tubules    101.9 Larval Fat Body    138.3 Larval Salivary Gland    160.6 Larval Trachea    153.275 Larval Carcass    85.775 Adult Head    122.8 Adult Eye    182.225 Adult Brain    163.3 Adult Thoracic-Abdominal Ganglion    121.2 Adult Crop    115 Adult Midgut    73.2 Adult Hindgut    112.4 Adult Malpighian Tubules    109.6 Adult Fat Body    54.6 Adult Salivary Gland    127.1 Adult Heart    50.9 Adult VirginFemale Spermatheca    109 Adult InseminatedFemale Spermatheca    126.4 Adult Ovary    293.5 Adult Testis    147.7 Adult Male Accessory Gland    211.9 Adult Carcass    73.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    309.3 Larval Midgut    56.9 Larval Hindgut    86.9 Larval Malpighian Tubules    101.9 Larval Fat Body    138.3 Larval Salivary Gland    160.6 Larval Trachea    153.275 Larval Carcass    85.775 Adult Head    122.8 Adult Eye    182.225 Adult Brain    163.3 Adult Thoracic-Abdominal Ganglion    121.2 Adult Crop    115 Adult Midgut    73.2 Adult Hindgut    112.4 Adult Malpighian Tubules    109.6 Adult Fat Body    54.6 Adult Salivary Gland    127.1 Adult Heart    50.9 Adult VirginFemale Spermatheca    109 Adult InseminatedFemale Spermatheca    126.4 Adult Ovary    293.5 Adult Testis    147.7 Adult Male Accessory Gland    211.9 Adult Carcass    73.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    309.3 Larval Midgut    56.9 Larval Hindgut    86.9 Larval Malpighian Tubules    101.9 Larval Fat Body    138.3 Larval Salivary Gland    160.6 Larval Trachea    153.275 Larval Carcass    85.775 Adult Head    122.8 Adult Eye    182.225 Adult Brain    163.3 Adult Thoracic-Abdominal Ganglion    121.2 Adult Crop    115 Adult Midgut    73.2 Adult Hindgut    112.4 Adult Malpighian Tubules    109.6 Adult Fat Body    54.6 Adult Salivary Gland    127.1 Adult Heart    50.9 Adult VirginFemale Spermatheca    109 Adult InseminatedFemale Spermatheca    126.4 Adult Ovary    293.5 Adult Testis    147.7 Adult Male Accessory Gland    211.9 Adult Carcass    73.1 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    309.3 Larval Midgut    56.9 Larval Hindgut    86.9 Larval Malpighian Tubules    101.9 Larval Fat Body    138.3 Larval Salivary Gland    160.6 Larval Trachea    153.275 Larval Carcass    85.775 Adult Head    122.8 Adult Eye    182.225 Adult Brain    163.3 Adult Thoracic-Abdominal Ganglion    121.2 Adult Crop    115 Adult Midgut    73.2 Adult Hindgut    112.4 Adult Malpighian Tubules    109.6 Adult Fat Body    54.6 Adult Salivary Gland    127.1 Adult Heart    50.9 Adult VirginFemale Spermatheca    109 Adult InseminatedFemale Spermatheca    126.4 Adult Ovary    293.5 Adult Testis    147.7 Adult Male Accessory Gland    211.9 Adult Carcass    73.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    309.3 Larval Midgut    56.9 Larval Hindgut    86.9 Larval Malpighian Tubules    101.9 Larval Fat Body    138.3 Larval Salivary Gland    160.6 Larval Trachea    153.275 Larval Carcass    85.775 Adult Head    122.8 Adult Eye    182.225 Adult Brain    163.3 Adult Thoracic-Abdominal Ganglion    121.2 Adult Crop    115 Adult Midgut    73.2 Adult Hindgut    112.4 Adult Malpighian Tubules    109.6 Adult Fat Body    54.6 Adult Salivary Gland    127.1 Adult Heart    50.9 Adult VirginFemale Spermatheca    109 Adult InseminatedFemale Spermatheca    126.4 Adult Ovary    293.5 Adult Testis    147.7 Adult Male Accessory Gland    211.9 Adult Carcass    73.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    309.3 Larval Midgut    56.9 Larval Hindgut    86.9 Larval Malpighian Tubules    101.9 Larval Fat Body    138.3 Larval Salivary Gland    160.6 Larval Trachea    153.275 Larval Carcass    85.775 Adult Head    122.8 Adult Eye    182.225 Adult Brain    163.3 Adult Thoracic-Abdominal Ganglion    121.2 Adult Crop    115 Adult Midgut    73.2 Adult Hindgut    112.4 Adult Malpighian Tubules    109.6 Adult Fat Body    54.6 Adult Salivary Gland    127.1 Adult Heart    50.9 Adult VirginFemale Spermatheca    109 Adult InseminatedFemale Spermatheca    126.4 Adult Ovary    293.5 Adult Testis    147.7 Adult Male Accessory Gland    211.9 Adult Carcass    73.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    309.3 Larval Midgut    56.9 Larval Hindgut    86.9 Larval Malpighian Tubules    101.9 Larval Fat Body    138.3 Larval Salivary Gland    160.6 Larval Trachea    153.275 Larval Carcass    85.775 Adult Head    122.8 Adult Eye    182.225 Adult Brain    163.3 Adult Thoracic-Abdominal Ganglion    121.2 Adult Crop    115 Adult Midgut    73.2 Adult Hindgut    112.4 Adult Malpighian Tubules    109.6 Adult Fat Body    54.6 Adult Salivary Gland    127.1 Adult Heart    50.9 Adult VirginFemale Spermatheca    109 Adult InseminatedFemale Spermatheca    126.4 Adult Ovary    293.5 Adult Testis    147.7 Adult Male Accessory Gland    211.9 Adult Carcass    73.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    122.8   NA  Eye    182.225   NA  Brain    163.3   309.3  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    121.2   NA  Crop    115   56.9  Midgut    73.2   86.9  Hindgut    112.4   101.9  Malpighian Tubules    109.6   138.3  Fat Body    54.6   160.6  Salivary Gland    127.1   NA  Heart    50.9   153.275  Trachea    NA   NA  VirginFemale Spermatheca    109   NA  InseminatedFemale Spermatheca    126.4   NA  Ovary    293.5   NA  Testis    147.7   NA  Male Accessory Gland    211.9   85.775  Carcass    73.1 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    65 central nervous system, larvae L3    70 central nervous system, pupae P8    27 head, virgin 1-day female    13 head, virgin 4-day female    17 head, virgin 20-day female    9 head, mated 1-day female    13 head, mated 4-day female    9 head, mated 20-day female    9 head, mated 1-day male    16 head, mated 4-day male    13 head, mated 20-day male    19 salivary gland, larvae L3 wandering    12 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    12 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    6 fat body, white prepupae    18 fat body, pupae P8    25 carcass, larvae L3 wandering    40 carcass, 1-day adult    6 carcass, 4-day adult    8 carcass, 20-day adult    10 ovary, virgin 4-day female    46 ovary, mated 4-day female    44 testis, mated 4-day male    111 accessory gland, mated 4-day male    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (65) central nervous system, larvae L3  (70) central nervous system, pupae P8  (27) head, virgin 1-day female    13 head, virgin 4-day female    17 head, virgin 20-day female    9 head, mated 1-day female    13 head, mated 4-day female    9 head, mated 20-day female    9 head, mated 1-day male    16 head, mated 4-day male    13 head, mated 20-day male    19 salivary gland, larvae L3 wandering    12 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    12 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    6 fat body, white prepupae    18 fat body, pupae P8    25 carcass, larvae L3 wandering  (40) carcass, 1-day adult    6 carcass, 4-day adult    8 carcass, 20-day adult    10 ovary, virgin 4-day female  (46) ovary, mated 4-day female  (44) testis, mated 4-day male  (111) accessory gland, mated 4-day male    25 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    65 central nervous system, larvae L3    70 central nervous system, pupae P8    27 head, virgin 1-day female    13 head, virgin 4-day female    17 head, virgin 20-day female    9 head, mated 1-day female    13 head, mated 4-day female    9 head, mated 20-day female    9 head, mated 1-day male    16 head, mated 4-day male    13 head, mated 20-day male    19 salivary gland, larvae L3 wandering    12 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    12 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    6 fat body, white prepupae    18 fat body, pupae P8    25 carcass, larvae L3 wandering    40 carcass, 1-day adult    6 carcass, 4-day adult    8 carcass, 20-day adult    10 ovary, virgin 4-day female    46 ovary, mated 4-day female    44 testis, mated 4-day male  (111) accessory gland, mated 4-day male    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    65 central nervous system, larvae L3    70 central nervous system, pupae P8    27 head, virgin 1-day female    13 head, virgin 4-day female    17 head, virgin 20-day female    9 head, mated 1-day female    13 head, mated 4-day female    9 head, mated 20-day female    9 head, mated 1-day male    16 head, mated 4-day male    13 head, mated 20-day male    19 salivary gland, larvae L3 wandering    12 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    12 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    6 fat body, white prepupae    18 fat body, pupae P8    25 carcass, larvae L3 wandering    40 carcass, 1-day adult    6 carcass, 4-day adult    8 carcass, 20-day adult    10 ovary, virgin 4-day female    46 ovary, mated 4-day female    44 testis, mated 4-day male    111 accessory gland, mated 4-day male    25 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    65 central nervous system, larvae L3    70 central nervous system, pupae P8    27 head, virgin 1-day female    13 head, virgin 4-day female    17 head, virgin 20-day female    9 head, mated 1-day female    13 head, mated 4-day female    9 head, mated 20-day female    9 head, mated 1-day male    16 head, mated 4-day male    13 head, mated 20-day male    19 salivary gland, larvae L3 wandering    12 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    12 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    6 fat body, white prepupae    18 fat body, pupae P8    25 carcass, larvae L3 wandering    40 carcass, 1-day adult    6 carcass, 4-day adult    8 carcass, 20-day adult    10 ovary, virgin 4-day female    46 ovary, mated 4-day female    44 testis, mated 4-day male    111 accessory gland, mated 4-day male    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (65) central nervous system, larvae L3  (70) central nervous system, pupae P8  27 head, virgin 1-day female    13 head, virgin 4-day female    17 head, virgin 20-day female    9 head, mated 1-day female    13 head, mated 4-day female    9 head, mated 20-day female    9 head, mated 1-day male    16 head, mated 4-day male    13 head, mated 20-day male    19 salivary gland, larvae L3 wandering    12 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    12 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    6 fat body, white prepupae    18 fat body, pupae P8    25 carcass, larvae L3 wandering  (40) carcass, 1-day adult    6 carcass, 4-day adult    8 carcass, 20-day adult    10 ovary, virgin 4-day female  (46) ovary, mated 4-day female  (44) testis, mated 4-day male  (111) accessory gland, mated 4-day male    25 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    65 central nervous system, larvae L3    70 central nervous system, pupae P8    27 head, virgin 1-day female    13 head, virgin 4-day female    17 head, virgin 20-day female    9 head, mated 1-day female    13 head, mated 4-day female    9 head, mated 20-day female    9 head, mated 1-day male    16 head, mated 4-day male    13 head, mated 20-day male    19 salivary gland, larvae L3 wandering    12 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    12 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    6 fat body, white prepupae    18 fat body, pupae P8    25 carcass, larvae L3 wandering    40 carcass, 1-day adult    6 carcass, 4-day adult    8 carcass, 20-day adult    10 ovary, virgin 4-day female    46 ovary, mated 4-day female    44 testis, mated 4-day male  111 accessory gland, mated 4-day male    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    65 central nervous system, larvae L3    70 central nervous system, pupae P8    27 head, virgin 1-day female    13 head, virgin 4-day female    17 head, virgin 20-day female    9 head, mated 1-day female    13 head, mated 4-day female    9 head, mated 20-day female    9 head, mated 1-day male    16 head, mated 4-day male    13 head, mated 20-day male    19 salivary gland, larvae L3 wandering    12 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    12 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    6 fat body, white prepupae    18 fat body, pupae P8    25 carcass, larvae L3 wandering    40 carcass, 1-day adult    6 carcass, 4-day adult    8 carcass, 20-day adult    10 ovary, virgin 4-day female    46 ovary, mated 4-day female    44 testis, mated 4-day male    111 accessory gland, mated 4-day male    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    70 embryo 02-04hr    105 embryo 04-06hr    102 embryo 06-08hr    106 embryo 08-10hr    90 embryo 10-12hr    85 embryo 12-14hr    43 embryo 14-16hr    39 embryo 16-18hr    26 embryo 18-20hr    20 embryo 20-22hr    14 embryo 22-24hr    15 larva L1    18 larva L2    19 larva L3 12hr old    13 larva L3 puffstage 1-2    23 larva L3 puffstage 3-6    30 larva L3 puffstage 7-9    35 white prepupae new    35 white prepupae 12hr    35 white prepupae 24hr    47 pupae 2d postWPP    30 pupae 3d postWPP    18 pupae 4d postWPP    17 adult male 01day    20 adult male 05day    23 adult male 30day    23 adult female 01day    28 adult female 05day    36 adult female 30day    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (70) embryo 02-04hr  (105) embryo 04-06hr  (102) embryo 06-08hr  (106) embryo 08-10hr  (90) embryo 10-12hr  (85) embryo 12-14hr  (43) embryo 14-16hr  (39) embryo 16-18hr  26 embryo 18-20hr    20 embryo 20-22hr    14 embryo 22-24hr    15 larva L1    18 larva L2    19 larva L3 12hr old    13 larva L3 puffstage 1-2    23 larva L3 puffstage 3-6  (30) larva L3 puffstage 7-9  (35) white prepupae new  (35) white prepupae 12hr  (35) white prepupae 24hr  (47) pupae 2d postWPP  (30) pupae 3d postWPP    18 pupae 4d postWPP    17 adult male 01day    20 adult male 05day    23 adult male 30day    23 adult female 01day  (28) adult female 05day  (36) adult female 30day  (37) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    70 embryo 02-04hr  105 embryo 04-06hr  102 embryo 06-08hr  106 embryo 08-10hr    90 embryo 10-12hr    85 embryo 12-14hr    43 embryo 14-16hr    39 embryo 16-18hr    26 embryo 18-20hr    20 embryo 20-22hr    14 embryo 22-24hr    15 larva L1    18 larva L2    19 larva L3 12hr old    13 larva L3 puffstage 1-2    23 larva L3 puffstage 3-6    30 larva L3 puffstage 7-9    35 white prepupae new    35 white prepupae 12hr    35 white prepupae 24hr    47 pupae 2d postWPP    30 pupae 3d postWPP    18 pupae 4d postWPP    17 adult male 01day    20 adult male 05day    23 adult male 30day    23 adult female 01day    28 adult female 05day    36 adult female 30day    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    70 embryo 02-04hr    105 embryo 04-06hr    102 embryo 06-08hr    106 embryo 08-10hr    90 embryo 10-12hr    85 embryo 12-14hr    43 embryo 14-16hr    39 embryo 16-18hr    26 embryo 18-20hr    20 embryo 20-22hr    14 embryo 22-24hr    15 larva L1    18 larva L2    19 larva L3 12hr old    13 larva L3 puffstage 1-2    23 larva L3 puffstage 3-6    30 larva L3 puffstage 7-9    35 white prepupae new    35 white prepupae 12hr    35 white prepupae 24hr    47 pupae 2d postWPP    30 pupae 3d postWPP    18 pupae 4d postWPP    17 adult male 01day    20 adult male 05day    23 adult male 30day    23 adult female 01day    28 adult female 05day    36 adult female 30day    37 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    70 embryo 02-04hr    105 embryo 04-06hr    102 embryo 06-08hr    106 embryo 08-10hr    90 embryo 10-12hr    85 embryo 12-14hr    43 embryo 14-16hr    39 embryo 16-18hr    26 embryo 18-20hr    20 embryo 20-22hr    14 embryo 22-24hr    15 larva L1    18 larva L2    19 larva L3 12hr old    13 larva L3 puffstage 1-2    23 larva L3 puffstage 3-6    30 larva L3 puffstage 7-9    35 white prepupae new    35 white prepupae 12hr    35 white prepupae 24hr    47 pupae 2d postWPP    30 pupae 3d postWPP    18 pupae 4d postWPP    17 adult male 01day    20 adult male 05day    23 adult male 30day    23 adult female 01day    28 adult female 05day    36 adult female 30day    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (70) embryo 02-04hr  (105) embryo 04-06hr  (102) embryo 06-08hr  (106) embryo 08-10hr  (90) embryo 10-12hr  (85) embryo 12-14hr  (43) embryo 14-16hr  (39) embryo 16-18hr  26 embryo 18-20hr    20 embryo 20-22hr    14 embryo 22-24hr    15 larva L1    18 larva L2    19 larva L3 12hr old    13 larva L3 puffstage 1-2    23 larva L3 puffstage 3-6  30 larva L3 puffstage 7-9  (35) white prepupae new  (35) white prepupae 12hr  (35) white prepupae 24hr  (47) pupae 2d postWPP  30 pupae 3d postWPP    18 pupae 4d postWPP    17 adult male 01day    20 adult male 05day    23 adult male 30day    23 adult female 01day  28 adult female 05day  (36) adult female 30day  (37) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    70 embryo 02-04hr  105 embryo 04-06hr  102 embryo 06-08hr  106 embryo 08-10hr    90 embryo 10-12hr    85 embryo 12-14hr    43 embryo 14-16hr    39 embryo 16-18hr    26 embryo 18-20hr    20 embryo 20-22hr    14 embryo 22-24hr    15 larva L1    18 larva L2    19 larva L3 12hr old    13 larva L3 puffstage 1-2    23 larva L3 puffstage 3-6    30 larva L3 puffstage 7-9    35 white prepupae new    35 white prepupae 12hr    35 white prepupae 24hr    47 pupae 2d postWPP    30 pupae 3d postWPP    18 pupae 4d postWPP    17 adult male 01day    20 adult male 05day    23 adult male 30day    23 adult female 01day    28 adult female 05day    36 adult female 30day    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    70 embryo 02-04hr    105 embryo 04-06hr    102 embryo 06-08hr    106 embryo 08-10hr    90 embryo 10-12hr    85 embryo 12-14hr    43 embryo 14-16hr    39 embryo 16-18hr    26 embryo 18-20hr    20 embryo 20-22hr    14 embryo 22-24hr    15 larva L1    18 larva L2    19 larva L3 12hr old    13 larva L3 puffstage 1-2    23 larva L3 puffstage 3-6    30 larva L3 puffstage 7-9    35 white prepupae new    35 white prepupae 12hr    35 white prepupae 24hr    47 pupae 2d postWPP    30 pupae 3d postWPP    18 pupae 4d postWPP    17 adult male 01day    20 adult male 05day    23 adult male 30day    23 adult female 01day    28 adult female 05day    36 adult female 30day    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    44 Schneider line 2 Sg4    55 embryonic 1182-4H    52 embryonic GM2    35 embryonic Kc167    25 embryonic S1    71 embryonic S3    26 leg disc CME L1    51 wing disc CME-W2    33 wing disc ML-DmD8    37 wing disc ML-DmD9    41 wing disc ML-DmD16-c3    56 wing disc ML-DmD21    104 wing disc ML-DmD32    57 haltere disc ML-DmD17-c3    77 eye-antennal disc ML-DmD11    49 antennal disc ML-DmD20-c5    88 mixed discs ML-DmD4-c1    58 CNS ML-DmBG1-c1    49 CNS ML-DmBG2-c2    39 tumorous blood cells mbn2    22 ovary fGS/OSS    49 ovary OSC    27 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (44) Schneider line 2 Sg4  (55) embryonic 1182-4H  (52) embryonic GM2  (35) embryonic Kc167    25 embryonic S1  (71) embryonic S3  26 leg disc CME L1  (51) wing disc CME-W2  (33) wing disc ML-DmD8  (37) wing disc ML-DmD9  (41) wing disc ML-DmD16-c3  (56) wing disc ML-DmD21  (104) wing disc ML-DmD32  (57) haltere disc ML-DmD17-c3  (77) eye-antennal disc ML-DmD11  (49) antennal disc ML-DmD20-c5  (88) mixed discs ML-DmD4-c1  (58) CNS ML-DmBG1-c1  (49) CNS ML-DmBG2-c2  (39) tumorous blood cells mbn2    22 ovary fGS/OSS  (49) ovary OSC  (27) ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    44 Schneider line 2 Sg4    55 embryonic 1182-4H    52 embryonic GM2    35 embryonic Kc167    25 embryonic S1    71 embryonic S3    26 leg disc CME L1    51 wing disc CME-W2    33 wing disc ML-DmD8    37 wing disc ML-DmD9    41 wing disc ML-DmD16-c3    56 wing disc ML-DmD21  104 wing disc ML-DmD32    57 haltere disc ML-DmD17-c3    77 eye-antennal disc ML-DmD11    49 antennal disc ML-DmD20-c5    88 mixed discs ML-DmD4-c1    58 CNS ML-DmBG1-c1    49 CNS ML-DmBG2-c2    39 tumorous blood cells mbn2    22 ovary fGS/OSS    49 ovary OSC    27 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    44 Schneider line 2 Sg4    55 embryonic 1182-4H    52 embryonic GM2    35 embryonic Kc167    25 embryonic S1    71 embryonic S3    26 leg disc CME L1    51 wing disc CME-W2    33 wing disc ML-DmD8    37 wing disc ML-DmD9    41 wing disc ML-DmD16-c3    56 wing disc ML-DmD21    104 wing disc ML-DmD32    57 haltere disc ML-DmD17-c3    77 eye-antennal disc ML-DmD11    49 antennal disc ML-DmD20-c5    88 mixed discs ML-DmD4-c1    58 CNS ML-DmBG1-c1    49 CNS ML-DmBG2-c2    39 tumorous blood cells mbn2    22 ovary fGS/OSS    49 ovary OSC    27 ovary OSS    15 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    44 Schneider line 2 Sg4    55 embryonic 1182-4H    52 embryonic GM2    35 embryonic Kc167    25 embryonic S1    71 embryonic S3    26 leg disc CME L1    51 wing disc CME-W2    33 wing disc ML-DmD8    37 wing disc ML-DmD9    41 wing disc ML-DmD16-c3    56 wing disc ML-DmD21    104 wing disc ML-DmD32    57 haltere disc ML-DmD17-c3    77 eye-antennal disc ML-DmD11    49 antennal disc ML-DmD20-c5    88 mixed discs ML-DmD4-c1    58 CNS ML-DmBG1-c1    49 CNS ML-DmBG2-c2    39 tumorous blood cells mbn2    22 ovary fGS/OSS    49 ovary OSC    27 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (44) Schneider line 2 Sg4  (55) embryonic 1182-4H  (52) embryonic GM2  (35) embryonic Kc167    25 embryonic S1  (71) embryonic S3  26 leg disc CME L1  (51) wing disc CME-W2  (33) wing disc ML-DmD8  (37) wing disc ML-DmD9  (41) wing disc ML-DmD16-c3  (56) wing disc ML-DmD21  (104) wing disc ML-DmD32  (57) haltere disc ML-DmD17-c3  (77) eye-antennal disc ML-DmD11  (49) antennal disc ML-DmD20-c5  (88) mixed discs ML-DmD4-c1  (58) CNS ML-DmBG1-c1  (49) CNS ML-DmBG2-c2  (39) tumorous blood cells mbn2    22 ovary fGS/OSS  (49) ovary OSC  27 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    44 Schneider line 2 Sg4    55 embryonic 1182-4H    52 embryonic GM2    35 embryonic Kc167    25 embryonic S1    71 embryonic S3    26 leg disc CME L1    51 wing disc CME-W2    33 wing disc ML-DmD8    37 wing disc ML-DmD9    41 wing disc ML-DmD16-c3    56 wing disc ML-DmD21  104 wing disc ML-DmD32    57 haltere disc ML-DmD17-c3    77 eye-antennal disc ML-DmD11    49 antennal disc ML-DmD20-c5    88 mixed discs ML-DmD4-c1    58 CNS ML-DmBG1-c1    49 CNS ML-DmBG2-c2    39 tumorous blood cells mbn2    22 ovary fGS/OSS    49 ovary OSC    27 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    44 Schneider line 2 Sg4    55 embryonic 1182-4H    52 embryonic GM2    35 embryonic Kc167    25 embryonic S1    71 embryonic S3    26 leg disc CME L1    51 wing disc CME-W2    33 wing disc ML-DmD8    37 wing disc ML-DmD9    41 wing disc ML-DmD16-c3    56 wing disc ML-DmD21    104 wing disc ML-DmD32    57 haltere disc ML-DmD17-c3    77 eye-antennal disc ML-DmD11    49 antennal disc ML-DmD20-c5    88 mixed discs ML-DmD4-c1    58 CNS ML-DmBG1-c1    49 CNS ML-DmBG2-c2    39 tumorous blood cells mbn2    22 ovary fGS/OSS    49 ovary OSC    27 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    12 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    26 Cadmium 50 mM 12 hrs, larvae L3    26 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    41 Copper 0.5 mM 12 hrs, larvae L3    25 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    20 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    18 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    36 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    34 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    12 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3  26 Cadmium 50 mM 12 hrs, larvae L3  26 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult  (41) Copper 0.5 mM 12 hrs, larvae L3    25 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    20 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3  (28) Ethanol 5% 3 hrs, larvae L3    18 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (36) Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult  (34) Paraquat 10 mM 48 hrs, 4-day adult  (27) Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    12 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    26 Cadmium 50 mM 12 hrs, larvae L3    26 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    41 Copper 0.5 mM 12 hrs, larvae L3    25 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    20 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    18 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    36 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    34 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    12 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    26 Cadmium 50 mM 12 hrs, larvae L3    26 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    41 Copper 0.5 mM 12 hrs, larvae L3    25 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    20 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    18 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    36 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    34 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    12 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    26 Cadmium 50 mM 12 hrs, larvae L3    26 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    41 Copper 0.5 mM 12 hrs, larvae L3    25 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    20 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    18 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    36 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    34 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    12 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3  26 Cadmium 50 mM 12 hrs, larvae L3  26 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult  (41) Copper 0.5 mM 12 hrs, larvae L3    25 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    20 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3  28 Ethanol 5% 3 hrs, larvae L3    18 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (36) Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult  (34) Paraquat 10 mM 48 hrs, 4-day adult  27 Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    12 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    26 Cadmium 50 mM 12 hrs, larvae L3    26 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    41 Copper 0.5 mM 12 hrs, larvae L3    25 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    20 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    18 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    36 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    34 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    12 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    26 Cadmium 50 mM 12 hrs, larvae L3    26 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    41 Copper 0.5 mM 12 hrs, larvae L3    25 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    20 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    18 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    36 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    34 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_30 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • LD23881 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039019 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6990-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for HP1c Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable HP1cf04929 viable, with Scer\GAL4pnr-MD237 HP1cGD12098 HP1cGD17526 Sterility Allele fertile HP1cf04929 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of HP1c Class Mutagen Stocks Known lesion HP1cf04929 piggyBac transposase 2 --
Alleles Carried on Transgenic Constructs ( 12 )
For All Alleles Carried on Transgenic Constructs Show
Allele of HP1c Class Mutagen Stocks Known lesion HP1cGD12098 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes HP1cGD17526 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes HP1cHMS00919 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes HP1cJF01297 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes HP1cKK112389 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes HP1cCHSc.hs.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes HP1cdsRNA.Scer\UAS in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes HP1chs.T:Ecol\dam,T:Hsap\MYC in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes HP1chs.T:Ecol\lacI in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes HP1chs.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes HP1cNIG.6990R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes HP1cT:Avic\GFP-EGFP in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6192 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD12098} NA P{GD17526} NA P{KK112389} NA P{NIG.6990R} NA P{TRiP.HMS00919} NA P{TRiP.JF01297} NA P{UAS-HP1c.RNAi.WIZ} NA heat-shock construct P{hs-HP1c.lacI} NA characterization construct P{vret.EGFP} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{WH}HP1cf04929 NA
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 9 terms )
Molecular Function
CV term Evidence References
chromatin binding inferred from direct assay (Doheny et al., 2008) methylated histone residue binding inferred from direct assay (Font-Burgada et al., 2008) protein binding inferred from physical interaction with row (Abel et al., 2009, Font-Burgada et al., 2008) inferred from physical interaction with woc (Font-Burgada et al., 2008)
Biological Process
CV term Evidence References
positive regulation of chromatin silencing at telomere inferred from mutant phenotype (Doheny et al., 2008) regulation of transcription from RNA polymerase II promoter inferred from mutant phenotype (Font-Burgada et al., 2008)
Cellular Component
CV term Evidence References
colocalizes_with euchromatin inferred from direct assay (Font-Burgada et al., 2008) nucleus inferred from direct assay (Font-Burgada et al., 2008) polytene chromosome interband inferred from direct assay (Font-Burgada et al., 2008, Abel et al., 2009) protein complex inferred from direct assay (Abel et al., 2009)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function
CV term Evidence References
chromatin binding inferred from sequence or structural similarity with mouse Cbx1 (FlyBase, 1992-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
HP1c - CG10681 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) HP1c - CG15514 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) HP1c - CG5565 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) HP1c - His3 far western blotting, anti tag western blot, pull down, western blot (Font-Burgada et al., 2008) HP1c - ctp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) HP1c - grau anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) HP1c - row experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Font-Burgada et al., 2008) HP1c - woc anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, peptide massfingerprinting (Font-Burgada et al., 2008)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions HP1c allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0039019 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42696
Orthologs
OrthoDB Orthologs (40) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6BG9GC Dipteran inclusive ortholog search EOG6VHKGH Insect inclusive ortholog search EOG67M0V1 Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search EOG6B09JP
Orthologs in Drosophila Species (EOG6BG9GC)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\HP1c     Drosophila simulans   Dsim\HP1C Y   Drosophila sechellia   Dsec\HP1C Y   Drosophila erecta   Dere\HP1C Y   Drosophila yakuba   Dyak\HP1C Y   Drosophila ananassae   Dana\HP1C Y   Drosophila pseudoobscura pseudoobscura   Dpse\HP1C Y   Drosophila persimilis   Dper\HP1C Y   Drosophila willistoni   Dwil\HP1C Y   Drosophila virilis   Dvir\HP1C Y   Drosophila mojavensis   Dmoj\HP1C Y   Drosophila grimshawi   Dgri\HP1C Y
Orthologs in non-Drosophila Dipterans (EOG6VHKGH)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ017443
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (EOG6B09JP)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\hpl-1 Y Caenorhabditis elegans Nematode  Cele\hpl-2 Y Danio rerio Zebrafish  Drer\cbx3a Y Danio rerio Zebrafish  Drer\cbx3b Y Danio rerio Zebrafish  Drer\cbx5 Y Danio rerio Zebrafish  Drer\cbx1b Y Xenopus tropicalis Western clawed frog  Xtro\cbx5 Y Xenopus tropicalis Western clawed frog  Xtro\cbx1 Y Xenopus tropicalis Western clawed frog  Xtro\cbx3 Y Gallus gallus Domestic chicken  Ggal\CBX3 Y Gallus gallus Domestic chicken  Ggal\ENSGALG00000000230 Y Mus musculus House mouse  Mmus\Cbx3 Y Mus musculus House mouse  Mmus\Cbx5 Y Mus musculus House mouse  Mmus\Gm6901 Y Mus musculus House mouse  Mmus\Cbx1 Y Mus musculus House mouse  Mmus\Cbx3 Y Mus musculus House mouse  Mmus\Cbx3 Y Rattus norvegicus Norway rat  Rnor\LOC100360260 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000031392 Y Rattus norvegicus Norway rat  Rnor\LOC689244 Y Rattus norvegicus Norway rat  Rnor\Cbx5 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000033992 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000029143 Y Rattus norvegicus Norway rat  Rnor\Cbx1 Y Homo sapiens Human  Hsap\CBX3 Y Homo sapiens Human  Hsap\CBX1 Y Homo sapiens Human  Hsap\CBX5 Y
Human Orthologs (3)
Gene OMIM HGNC Hsap\CBX3     Hsap\CBX1     Hsap\CBX5
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\HP1C Drosophila sechellia Dsec\HP1C Drosophila erecta Dere\HP1C Drosophila yakuba Dyak\HP1C Drosophila ananassae Dana\HP1C Drosophila pseudoobscura pseudoobscura Dpse\HP1C Drosophila persimilis Dper\HP1C Drosophila willistoni Dwil\HP1C Drosophila virilis Dvir\HP1C Drosophila mojavensis Dmoj\HP1C Drosophila grimshawi Dgri\HP1C
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	18819 w1118; PBac{WH}HP1cf04929 31339 y1 v1; P{TRiP.JF01297}attP2 33962 y1 sc* v1; P{TRiP.HMS00919}attP2
Harvard	- PBac{WH}HP1cf04929
VDRC	v104893 P{KK112389}VIE-260B v27782 w1118; P{GD12098}v27782 v50520 w1118; P{GD17526}v50520 v27779 w1118; P{GD12098}v27779/TM3
Genomic Clones ( 1 )
	BACR23F10 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 76 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD23881
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH16996 LD09889 LD31380 LP03264 RE27296 RE28447 RE28872 RH41355
Other clones	156318 Dmel_neb_009694_0909_3092 Dmel_neb_011961_0670_2339 EK058039 EK259134 FGM306E01 LD29216 RP003003604 RP003004523 RP003047167 RP003063139 RP003063772 RP003064354 RP003084273 RP003094471 RP003098953 RP003111135 RP003114667 RP003129816 RP003133789 RP003134425 RP003143996 RP003147714 RP003147903 RP003152032 RP003165014 RP003179060 RP003187564 RP003214359 RP003226379 RP003232909 RP003250148 RP003250655 RP003251944 RP003258459 RP003267093 RP003267258 RP003270399 RP003273840 RP003279445 RP003287019 RP003293286 RP003310404 RP003325465 RP003326658 RP003332838 RP003376678 RP003381848 RP003388738 RP003399300 RP003401852 RP003435203 RP003467342 RP003487787 RP003503989 RP003505878 RP003506044 RP003506885 RP003509139 RP003540055 RP003542490 RP003557505 RP003561726 RP003606111 RP003646201 RP003665741 RP003680048
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0039019 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42696
Antibody Information
	polyclonal (Font-Burgada et al., 2008, Riddle et al., 2011)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	DNA-protein interactions: genome-wide binding profile assayed for HP1c protein in Kc167 cells; see Chromatin_types_NKI collection report. Individual protein-binding experiments listed under "Samples" at GEO_GSE22069 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22069). (Filion et al., 2010)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_142836 RefSeq (Proteins) • NP_651093 DDBJ / EMBL / GenBank • AA820321 AAF56059 AAL28870 AW942691 AY061322 CZ487515 Entrez Gene - A searchable database of RefSeq genes. • 42696 UniProtKB/TrEMBL • Q9VCU6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Chromo domain subgroup (IPR017984) Chromo domain/shadow (IPR000953) Chromo shadow domain (IPR008251) Chromo domain-like (IPR016197) Chromo domain, conserved site (IPR023779) Chromo domain (IPR023780) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD23881
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0039019 DRSC - Results from RNAi screens. • FBgn0039019 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039019 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6990-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0039019 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42696 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/hp1c.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42696 modMine - Data generated by the modENCODE project. • FBgn0039019
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	CG6990 (Przewloka et al., 2007, Keleman et al., 2009.8.5, Ni et al., 2008, Levine et al., 2012, Ni et al., 2010.12.1) HP1 (Schulze et al., 2009, Wood et al., 2010) Hp1c (Mason et al., 2004, Doheny et al., 2008) HP1c (Moorman et al., 2006, Moorman et al., 2006, Vermaak et al., 2005, Przewloka et al., 2007, Li et al., 2002, Brower-Toland et al., 2007, Kharchenko et al., 2011, Lin et al., 2008, Abel et al., 2009, Filion et al., 2010, Kwon et al., 2010, Handler et al., 2011, Sakoparnig et al., 2012, Demakov et al., 2011, Japanese National Institute of Genetics, 2012.5.21, Antao et al., 2012) hp1c (Font-Burgada et al., 2008) HP1C (van Steensel et al., 2010, Levine et al., 2012, Levine et al., 2012)
Name Synonym	Heterochromatin protein 1c (Moorman et al., 2006) Heterochromatin Protein 1c   HP1c
Secondary FlyBase IDs
References ( 53 )
Generate a list of	All references relating to this gene ( 53 )
List References by type	Research paper  ( 28 ) Supplementary material  ( 6 ) Review  ( 2 ) Personal communication to FlyBase  ( 10 ) FlyBase analysis  ( 2 ) Stock list  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 8 )
	Antao et al., 2012, Mol. Cell. Biol. 32(12): 2170--2182 Protein Landscape at Drosophila melanogaster Telomere-Associated Sequence Repeats. [FBrf0218429] Levine et al., 2012, PLoS Genet. 8(6): e1002729 Phylogenomic Analysis Reveals Dynamic Evolutionary History of the Drosophila Heterochromatin Protein 1 (HP1) Gene Family. [FBrf0218715] Riddle et al., 2012, PLoS Genet. 8(9): e1002954 Enrichment of HP1a on Drosophila Chromosome 4 Genes Creates an Alternate Chromatin Structure Critical for Regulation in this Heterochromatic Domain. [FBrf0219520] Sakoparnig et al., 2012, J. Comput. Biol. 19(2): 126--138 Binding profiles of chromatin-modifying proteins are predictive for transcriptional activity and promoter-proximal pausing. [FBrf0217402] Demakov et al., 2011, BMC Genomics 12: 566 Protein composition of interband regions in polytene and cell line chromosomes of Drosophila melanogaster. [FBrf0216974] Handler et al., 2011, EMBO J. 30(19): 3977--3993 A systematic analysis of Drosophila TUDOR domain-containing proteins identifies Vreteno and the Tdrd12 family as essential primary piRNA pathway factors. [FBrf0216344] Kharchenko et al., 2011, Nature 471(7339): 480--485 Comprehensive analysis of the chromatin landscape in Drosophila melanogaster. [FBrf0213294] Riddle et al., 2011, Genome Res. 21(2): 147--163 Plasticity in patterns of histone modifications and chromosomal proteins in Drosophila heterochromatin. [FBrf0213099] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...