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Gene Dmel\p53

General Information
Symbol	Dmel\p53	Species	D. melanogaster
Name	p53	Annotation symbol	CG33336
Feature type	protein_coding_gene	FlyBase ID	FBgn0039044
Gene Model Status	Current	Stock availability	33 publicly available
Also Known As	Dmp53, dp53, CG10873
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	94D10-94D10	Sequence location	3R:18,875,379..18,879,804 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene p53 is referred to in FlyBase by the symbol Dmel\p53 (CG33336, FBgn0039044). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; transcription factor binding. There is experimental evidence for 19 unique biological process terms, many of which group under: biological regulation; programmed cell death; cell death; regulation of apoptosis; response to abiotic stimulus; response to DNA damage stimulus; localization; response to ionizing radiation; response to UV; determination of adult lifespan; growth; cell cycle; multicellular organism reproduction. 49 alleles are reported. The phenotypes of these alleles are annotated with: eye disc; eye; interommatidial bristle; ovary; pole cell; germline cell; wing; outer photoreceptor cell; egg chamber; ommatidium. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Transcription factor p53, C-terminal, Drosophila; p53 tumour suppressor family; p53, DNA-binding domain; p53-like transcription factor, DNA-binding; p53/RUNT-type transcription factor, DNA-binding domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult crop, adult midgut, adult hindgut, larval/adult Malpighian tubules, adult salivary gland, adult ovary, adult male accessory gland. Gene sequence location is 3R:18875379..18879804.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Controlled Vocabulary Terms negative regulation of photoreceptor cell differentiation transcriptionally active chromatin transcription factor binding References Pedersen et al., 2010, Genome 53(10): 778--786 Kim et al., 2010, Exp. Gerontol. 45(12): 984--987 Sequence features BKN33065 HFA17024
FB2011_10	References Mauri et al., 2008, J. Biol. Chem. 283(30): 20848--20856
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 94D10-94D10   Limits computationally determined from genome sequence between P{lacW}GclmL0580 and P{EP}hhEP3521
Experimentally Determined Cytological Location
Cytogenetic map Notes References 94D-94D     (Jin, 2000.3.30) 94D-94D     (Potter, 2000.3.12) 94D-94D     (Brodsky, 2000.1.13) 94D-94D   (determined by in situ hybridisation)   (Ollmann et al., 2000) 94D-94D     (Karim, 2000.3.5)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\p53 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.39 Gene merge based on EST data
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) p53-RA FBtr0084359  NM_206545   1577   385 p53-RB FBtr0084360  NM_206544   1870   495 p53-RC FBtr0301765  NM_001170223   2095   385 p53-RD FBtr0308690     1326   318
Additional Transcript Data & Comments
Reported size (kB)	1.523 (longest cDNA) (Brodsky et al., 2000) 1.381 (longest cDNA) (Jin et al., 2000) 1.6 (northern blot) (Ollmann et al., 2000)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein p53-PA   FBpp0083752   43.7   385   7.30     NP_996268   AAF56087 p53-PB   FBpp0083753   55.6   495   6.69     NP_996267   AAN13925 p53-PC   FBpp0290979   43.7   385   7.30     NP_001163694   ACZ94989 p53-PD   FBpp0300896   36.1   318   8.71
Additional Polypeptide Data & Comments
Reported size (kDa)	385 (aa) (Ollmann et al., 2000, Jin et al., 2000, Brodsky et al., 2000)
Comments	Drosophila p53 protein binds the human p53 protein binding sites in the human p21 and GACC45 genes. Overexpression of Drosophila p53 protein induces apoptosis but not G1 arrest. X-ray induced apoptosis is blocked upon expression of a mutant form of p53 protein that has dominant-negative activity. p53-related genes are present in other insects (Tribolium castaneum and Leptinotarsa decemlineata EST projects). (Brodsky et al., 2000)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • p53-like transcription factor, DNA-binding (IPR008967) p53, DNA-binding domain (IPR011615) p53/RUNT-type transcription factor, DNA-binding domain (IPR012346) Transcription factor p53, C-terminal, Drosophila (IPR024631) p53 tumour suppressor family (IPR002117)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202039   AA951206   AE014297 AAF56087   AE014297 AAN13925   AC008200   AE014297 ACZ94989   AF192555 AAL56639   AF224713 AAF40427   AF224714   AF244918 AAF61572   AF250918 AAF74277   AF263722 AAF75270   AI061944   AI109492   AI134202   AI514845   AI516233   AI516383   AI517416   AI518673   AW940417   AY069096 AAL39241   BF491571   BI632541   BT001357 AAN71112   BT124732   CL526095   CL943607   CO308314   CO308516   DQ191318 ABB80263   DQ191319 ABB80264   DQ191320 ABB80265   EC051771   EC053758   EC056252   EC062042   EC204724   EC249565   GH757021   GH795509   GH796807   GH803729   GH809104   GH815941   GH823632   GH837757   GH842629   GH845748   GH848774   GH849536   GH850397   GH851555   GH880714   GH881538   GH888407   GH895078   GH897009   GH900151   GH909575   GH939296   GH940687   GH940748   GH944515   GH947244   GH948936   GH950794   GH955540   GH961678   GH965571   GH969788   GH973014   GH983046   GH984019
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q2XVY6 Q2XVY7 Q8IH92 Q8IMZ4 Q9N6D8
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 4   organism | uniform   (Ollmann et al., 2000) Comment:maternally deposited; NOT pole cell embryonic stage 1 -- 5   organism | ubiquitous   (Jin et al., 2000) Comment:maternal contribution embryonic stage 6 -- 13   organism | ubiquitous   (Jin et al., 2000) embryonic stage 10   mesoderm   (Ollmann et al., 2000) foregut primordium   (Ollmann et al., 2000) anterior midgut primordium   (Ollmann et al., 2000) hindgut proper primordium   (Ollmann et al., 2000) posterior midgut primordium   (Ollmann et al., 2000) embryonic stage 16   germline cell   (Ollmann et al., 2000) embryonic/larval hindgut | restricted   (Ollmann et al., 2000) Comment:small patch of cells oogenesis stage S10 & adult stage | female   nurse cell   (Jin et al., 2000, Ollmann et al., 2000) Comment:undetectable in follicle cells adult stage | female & oogenesis stage S10   oocyte   (Ollmann et al., 2000) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage     (Ollmann et al., 2000) embryonic stage 10   mesoderm   (Ollmann et al., 2000) embryonic/larval midgut   (Ollmann et al., 2000) embryonic/larval hindgut   (Ollmann et al., 2000) embryonic/larval foregut   (Ollmann et al., 2000) embryonic stage 16   embryonic/larval hindgut | restricted   (Ollmann et al., 2000) larval stage     (Ollmann et al., 2000) adult stage     (Ollmann et al., 2000) adult stage & oogenesis stage S10   oocyte   (Ollmann et al., 2000) nurse cell   (Ollmann et al., 2000) RNase protection, primer extension, SI map Stage Tissue/Position (including subcellular localization) Reference embryonic stage     (Jin et al., 2000) embryonic stage -- adult stage     (Jin et al., 2000) adult stage | female     (Jin et al., 2000) adult stage & oogenesis stage S10   nurse cell   (Jin et al., 2000)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0039044    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0039044 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0039044 expression level Developmental Stage   Expression Level embryo 00-02hr    1637 embryo 02-04hr    1373 embryo 04-06hr    792 embryo 06-08hr    1069 embryo 08-10hr    1139 embryo 10-12hr    776 embryo 12-14hr    641 embryo 14-16hr    527 embryo 16-18hr    489 embryo 18-20hr    402 embryo 20-22hr    691 embryo 22-24hr    718 larva L1    689 larva L2    354 larva L3 12hr old    282 larva L3 puffstage 1-2    333 larva L3 puffstage 3-6    378 larva L3 puffstage 7-9    442 white prepupae new    470 white prepupae 12hr    562 white prepupae 24hr    574 pupae 2d postWPP    440 pupae 3d postWPP    264 pupae 4d postWPP    246 adult male 01day    333 adult male 05day    404 adult male 30day    449 adult female 01day    749 adult female 05day    1131 adult female 30day    1249 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1637) embryo 02-04hr  (1373) embryo 04-06hr  (792) embryo 06-08hr  (1069) embryo 08-10hr  (1139) embryo 10-12hr  (776) embryo 12-14hr  (641) embryo 14-16hr  (527) embryo 16-18hr  (489) embryo 18-20hr  (402) embryo 20-22hr  (691) embryo 22-24hr  (718) larva L1  (689) larva L2  (354) larva L3 12hr old  (282) larva L3 puffstage 1-2  (333) larva L3 puffstage 3-6  (378) larva L3 puffstage 7-9  (442) white prepupae new  (470) white prepupae 12hr  (562) white prepupae 24hr  (574) pupae 2d postWPP  (440) pupae 3d postWPP  (264) pupae 4d postWPP  (246) adult male 01day  (333) adult male 05day  (404) adult male 30day  (449) adult female 01day  (749) adult female 05day  (1131) adult female 30day  (1249) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (1637) embryo 02-04hr    1373 embryo 04-06hr    792 embryo 06-08hr    1069 embryo 08-10hr    1139 embryo 10-12hr    776 embryo 12-14hr    641 embryo 14-16hr    527 embryo 16-18hr    489 embryo 18-20hr    402 embryo 20-22hr    691 embryo 22-24hr    718 larva L1    689 larva L2    354 larva L3 12hr old    282 larva L3 puffstage 1-2    333 larva L3 puffstage 3-6    378 larva L3 puffstage 7-9    442 white prepupae new    470 white prepupae 12hr    562 white prepupae 24hr    574 pupae 2d postWPP    440 pupae 3d postWPP    264 pupae 4d postWPP    246 adult male 01day    333 adult male 05day    404 adult male 30day    449 adult female 01day    749 adult female 05day    1131 adult female 30day    1249 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1637 embryo 02-04hr    1373 embryo 04-06hr    792 embryo 06-08hr    1069 embryo 08-10hr    1139 embryo 10-12hr    776 embryo 12-14hr    641 embryo 14-16hr    527 embryo 16-18hr    489 embryo 18-20hr    402 embryo 20-22hr    691 embryo 22-24hr    718 larva L1    689 larva L2    354 larva L3 12hr old    282 larva L3 puffstage 1-2    333 larva L3 puffstage 3-6    378 larva L3 puffstage 7-9    442 white prepupae new    470 white prepupae 12hr    562 white prepupae 24hr    574 pupae 2d postWPP    440 pupae 3d postWPP    264 pupae 4d postWPP    246 adult male 01day    333 adult male 05day    404 adult male 30day    449 adult female 01day    749 adult female 05day    1131 adult female 30day    1249 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1637 embryo 02-04hr    1373 embryo 04-06hr    792 embryo 06-08hr    1069 embryo 08-10hr    1139 embryo 10-12hr    776 embryo 12-14hr    641 embryo 14-16hr    527 embryo 16-18hr    489 embryo 18-20hr    402 embryo 20-22hr    691 embryo 22-24hr    718 larva L1    689 larva L2    354 larva L3 12hr old    282 larva L3 puffstage 1-2    333 larva L3 puffstage 3-6    378 larva L3 puffstage 7-9    442 white prepupae new    470 white prepupae 12hr    562 white prepupae 24hr    574 pupae 2d postWPP    440 pupae 3d postWPP    264 pupae 4d postWPP    246 adult male 01day    333 adult male 05day    404 adult male 30day    449 adult female 01day    749 adult female 05day    1131 adult female 30day    1249 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0039044 expression level Developmental Stage   Expression Level embryo 00-02hr    1637 embryo 02-04hr    1373 embryo 04-06hr    792 embryo 06-08hr    1069 embryo 08-10hr    1139 embryo 10-12hr    776 embryo 12-14hr    641 embryo 14-16hr    527 embryo 16-18hr    489 embryo 18-20hr    402 embryo 20-22hr    691 embryo 22-24hr    718 larva L1    689 larva L2    354 larva L3 12hr old    282 larva L3 puffstage 1-2    333 larva L3 puffstage 3-6    378 larva L3 puffstage 7-9    442 white prepupae new    470 white prepupae 12hr    562 white prepupae 24hr    574 pupae 2d postWPP    440 pupae 3d postWPP    264 pupae 4d postWPP    246 adult male 01day    333 adult male 05day    404 adult male 30day    449 adult female 01day    749 adult female 05day    1131 adult female 30day    1249 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1637) embryo 02-04hr  (1373) embryo 04-06hr  (792) embryo 06-08hr  (1069) embryo 08-10hr  (1139) embryo 10-12hr  (776) embryo 12-14hr  (641) embryo 14-16hr  (527) embryo 16-18hr  (489) embryo 18-20hr  (402) embryo 20-22hr  (691) embryo 22-24hr  (718) larva L1  (689) larva L2  (354) larva L3 12hr old  (282) larva L3 puffstage 1-2  (333) larva L3 puffstage 3-6  (378) larva L3 puffstage 7-9  (442) white prepupae new  (470) white prepupae 12hr  (562) white prepupae 24hr  (574) pupae 2d postWPP  (440) pupae 3d postWPP  (264) pupae 4d postWPP  (246) adult male 01day  (333) adult male 05day  (404) adult male 30day  (449) adult female 01day  (749) adult female 05day  (1131) adult female 30day  (1249) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  1637 embryo 02-04hr    1373 embryo 04-06hr    792 embryo 06-08hr    1069 embryo 08-10hr    1139 embryo 10-12hr    776 embryo 12-14hr    641 embryo 14-16hr    527 embryo 16-18hr    489 embryo 18-20hr    402 embryo 20-22hr    691 embryo 22-24hr    718 larva L1    689 larva L2    354 larva L3 12hr old    282 larva L3 puffstage 1-2    333 larva L3 puffstage 3-6    378 larva L3 puffstage 7-9    442 white prepupae new    470 white prepupae 12hr    562 white prepupae 24hr    574 pupae 2d postWPP    440 pupae 3d postWPP    264 pupae 4d postWPP    246 adult male 01day    333 adult male 05day    404 adult male 30day    449 adult female 01day    749 adult female 05day    1131 adult female 30day    1249 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1637 embryo 02-04hr    1373 embryo 04-06hr    792 embryo 06-08hr    1069 embryo 08-10hr    1139 embryo 10-12hr    776 embryo 12-14hr    641 embryo 14-16hr    527 embryo 16-18hr    489 embryo 18-20hr    402 embryo 20-22hr    691 embryo 22-24hr    718 larva L1    689 larva L2    354 larva L3 12hr old    282 larva L3 puffstage 1-2    333 larva L3 puffstage 3-6    378 larva L3 puffstage 7-9    442 white prepupae new    470 white prepupae 12hr    562 white prepupae 24hr    574 pupae 2d postWPP    440 pupae 3d postWPP    264 pupae 4d postWPP    246 adult male 01day    333 adult male 05day    404 adult male 30day    449 adult female 01day    749 adult female 05day    1131 adult female 30day    1249 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1637 embryo 02-04hr    1373 embryo 04-06hr    792 embryo 06-08hr    1069 embryo 08-10hr    1139 embryo 10-12hr    776 embryo 12-14hr    641 embryo 14-16hr    527 embryo 16-18hr    489 embryo 18-20hr    402 embryo 20-22hr    691 embryo 22-24hr    718 larva L1    689 larva L2    354 larva L3 12hr old    282 larva L3 puffstage 1-2    333 larva L3 puffstage 3-6    378 larva L3 puffstage 7-9    442 white prepupae new    470 white prepupae 12hr    562 white prepupae 24hr    574 pupae 2d postWPP    440 pupae 3d postWPP    264 pupae 4d postWPP    246 adult male 01day    333 adult male 05day    404 adult male 30day    449 adult female 01day    749 adult female 05day    1131 adult female 30day    1249 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0039044    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0039044 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult crop, adult midgut, adult hindgut, larval/adult Malpighian tubules, adult salivary gland, adult ovary, adult male accessory gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Heatmap Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary no informative data Adult Testis no informative data Adult Male Accessory Gland no informative data Adult Carcass no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_13
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039044 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10873-RA;CG31325-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for p53 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4elav-C155 p53GUS.PB semi-lethal, with Scer\GAL4Act5C.PI p53Scer\UAS.cJa viable p5311-1B-1 p53E4 p53E8 p53EY09278 p53EY14108 p53EY16724 p53GMR.Ex viable, with Scer\GAL4pnr-MD237 p53GD4483 p53GD11134 Sterility Allele fertile p53EY09278 p53EY14108 p53EY16724 sterile | partially p53E4 Other Phenotypes Allele aging defective p53E4 cell death defective (with p53-ns.3') p53-ns.5' cell death defective (with p53-ns.5') p53-ns.3' cell death defective | conditional p535A-1-4 chemical resistant | RU486 conditional, with Scer\GAL4elav.Switch.PO p53259H.GUS p53Ct.GUS decreased cell death p535A-1-4 decreased cell death, with Scer\GAL4en-e16E p53259H.GUS p53Ct.GUS decreased cell death, with Scer\GAL4GMR.PF p53Ct.GUS decreased cell death | recessive p535A-1-4 decreased cell number, with Scer\GAL4nos.UTR.T:Hsim\VP16 p53Scer\UAS.P\T.cBa decreased cell number | pupal stage p53GMR.Ex decreased cell number | pupal stage | somatic clone, with Scer\GAL4GMR.PU p53GUS.PB decreased cell number | third instar larval stage p53GMR.Ex decreased cell number | third instar larval stage, with Scer\GAL4GMR.PU p53GUS.PB increased cell death p53GMR.Ex p53Scer\UAS.cJa increased cell death, with Scer\GAL4Bx-MS1096 p53EP-1 p53GUS.PB increased cell death, with Scer\GAL4en-e16E p53GUS.PB increased cell death, with Scer\GAL4GMR.PF p53EP-1 p53Scer\UAS.cJa p53Scer\UAS.cPa p53Scer\UAS.Ex increased cell death | conditional p5311-1B-1 p53259H.GUS increased cell death | germline clone, with Scer\GAL4GR1 p53Scer\UAS.P\T.cBa increased cell death | germline clone, with Scer\GAL4nos.UTR.T:Hsim\VP16 p53Scer\UAS.P\T.cBa increased cell death | third instar larval stage p53GMR.Ex increased cell death | third instar larval stage, with Scer\GAL4GMR.PU p53GUS.PB long lived, with Scer\GAL4elav-C155 p53Ct.GUS long lived | female | RU486 conditional, with Scer\GAL4Act5C.Switch.PR p53259H.GUS long lived | RU486 conditional, with Scer\GAL4elav.Switch.PO p53259H.GUS p53Ct.GUS mitotic cell cycle defective p53GMR.Ex radiation sensitive p535A-1-4 p53E4 radiation sensitive (with p53-ns.3') p53-ns.5' radiation sensitive (with p53-ns.5') p53-ns.3' short lived (with p53-ns.3') p53-ns.5' short lived (with p53-ns.5') p53-ns.3' size defective | adult stage p53GMR.Ex size defective | adult stage, with Scer\GAL4GMR.PU p53GUS.PB visible p53GMR.Ex visible, with Scer\GAL4Bx-MS1096 p53EP-1 p53GUS.PB visible, with Scer\GAL4GMR.PF p53EP-1 p53GUS.PB p53S4A.Scer\UAS p53S20A.Scer\UAS p53Scer\UAS.cPa p53Scer\UAS.Ex visible | adult stage p53GMR.Ex visible | adult stage, with Scer\GAL4GMR.PU p53GUS.PB wild-type p53H159N.GMR.Ex p53R155H.GMR.Ex Phenotype manifest in Allele cone cell | pupal stage p53GMR.Ex cone cell | third instar larval stage p53GMR.Ex egg chamber, with Scer\GAL4GR1 p53Scer\UAS.P\T.cBa eye p53GMR.Ex p53H159N.GMR.Ex p53R155H.GMR.Ex eye, with Scer\GAL4ey.PH p53Scer\UAS.Ex eye, with Scer\GAL4GMR.PF p53EP-1 p53GUS.PB p53S20A.Scer\UAS p53S4A.Scer\UAS p53Scer\UAS.Ex p53Scer\UAS.cJa p53Scer\UAS.cPa p53Scer\UAS.P\T.cBa eye, with Scer\GAL4GMR.PU p53GUS.PB eye | conditional p5311-1B-1 p53259H.GUS eye disc p535A-1-4 p53GMR.Ex eye disc, with Scer\GAL4GMR.PF p53GUS.PB p53Scer\UAS.cPa eye disc | posterior | third instar larval stage p53GMR.Ex eye disc | posterior | third instar larval stage, with Scer\GAL4GMR.PU p53GUS.PB eye disc | pupal stage p53GMR.Ex germline cell, with Scer\GAL4nos.UTR.T:Hsim\VP16 p53Scer\UAS.P\T.cBa interommatidial bristle p53GMR.Ex interommatidial bristle, with Scer\GAL4GMR.PF p53Scer\UAS.cPa p53Scer\UAS.P\T.cBa ommatidium p53GMR.Ex ommatidium, with Scer\GAL4GMR.PF p53Scer\UAS.cPa p53Scer\UAS.P\T.cBa ommatidium | pupal stage p53GMR.Ex ommatidium | pupal stage | somatic clone, with Scer\GAL4GMR.PU p53GUS.PB oocyte | oogenesis stage S2 p532 oocyte | oogenesis stage S2 (with Dp(3;3)p53-ns) p5311-1B-1 oocyte | oogenesis stage S2 (with p532) p5311-1B-1 oocyte | oogenesis stage S2 (with p5311-1B-1) p532 outer photoreceptor cell p53Scer\UAS.cJa ovary, with Scer\GAL4nos.UTR.T:Hsim\VP16 p53Scer\UAS.P\T.cBa photoreceptor cell R7 | pupal stage | somatic clone, with Scer\GAL4GMR.PU p53GUS.PB photoreceptor cell R7 | third instar larval stage p53GMR.Ex photoreceptor cell R7 | third instar larval stage, with Scer\GAL4GMR.PU p53GUS.PB pole cell p5311-1B-1 p535A-1-4 p53unspecified pole cell (with Dp(3;3)p53-ns) p535A-1-4 wing, with Scer\GAL4Bx-MS1096 p53EP-1 p53GUS.PB wing disc | posterior compartment, with Scer\GAL4en-e16E p53259H.GUS p53Ct.GUS p53H159N.Scer\UAS.Ex p53R155H.Scer\UAS.Ex
Classical Alleles ( 13 )
For All Classical Alleles Show
Allele of p53 Class Mutagen Stocks Known lesion p53-ns.3' SCEI endonuclease FLPase 1 Yes p53-ns.5' SCEI endonuclease FLPase 1 Yes p5311-1B-1 recombination 1 Yes p535A-1-4 recombination 1 Yes p53EY09278 P-element activity 1 Yes p53EY14108 P-element activity 1 -- p53EY16724 P-element activity 1 -- p53MI01307 1 -- p532 0 -- p53E4 Delta2-3 0 Yes p53E8 Delta2-3 0 Yes p53EP-1 P-element activity 0 Yes p53unspecified 0 --
Alleles Carried on Transgenic Constructs ( 36 )
For All Alleles Carried on Transgenic Constructs Show
Allele of p53 Class Mutagen Stocks Known lesion p53H159N.Scer\UAS.Ex in vitro construct - regulatory fusion in vitro construct - amino acid replacement 3 Yes p53R155H.GMR.Ex gain of function allele in vitro construct - regulatory fusion in vitro construct - amino acid replacement 3 Yes p53vg.MQ.Exel in vitro construct - regulatory fusion 3 Yes p53GD11134 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes p53GD4483 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes p53GMR.Ex in vitro construct - regulatory fusion 2 Yes p53Scer\UAS.Ex in vitro construct - regulatory fusion 2 Yes p53sev.Exel in vitro construct - regulatory fusion 2 Yes p53259H.GUS gain of function allele in vitro construct - regulatory fusion in vitro construct - amino acid replacement 1 Yes p53Ct.GUS gain of function allele in vitro construct - deletion 1 Yes p53ey.3.5.Exel in vitro construct - regulatory fusion 1 Yes p53GUS.PB in vitro construct - regulatory fusion 1 Yes p53JF02513 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes p53KK113065 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes p53R155H.Scer\UAS.Ex in vitro construct - regulatory fusion in vitro construct - amino acid replacement 1 Yes p53155H.GUS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes p532.8.Scer\SceI.RS in vitro construct - site directed mutagenesis in vitro construct - deletion 0 Yes p538.6.Scer\SceI.RS in vitro construct 0 Yes p53Act5C.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes p53D259H.cPa in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes p53D259H.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes p53dsRNA.Scer\UAS in vitro construct - RNAi in vitro construct - regulatory fusion 0 -- p53fl.Act5C in vitro construct - regulatory fusion 0 Yes p53H159N.GMR.Ex gain of function allele in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes p53mut155.Act5C in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes p53S16A.cPa in vitro construct - amino acid replacement 0 Yes p53S20A.cPa in vitro construct - amino acid replacement in vitro construct - regulatory fusion 0 Yes p53S20A.Scer\UAS in vitro construct - amino acid replacement in vitro construct - regulatory fusion 0 Yes p53S4A.cPa in vitro construct - amino acid replacement in vitro construct - regulatory fusion 0 Yes p53S4A.Scer\UAS in vitro construct - amino acid replacement in vitro construct - regulatory fusion 0 Yes p53S8A.cPa in vitro construct - amino acid replacement 0 Yes p53Scer\SceI.RS.cXa in vitro construct 0 Yes p53Scer\UAS.cJa in vitro construct - regulatory fusion 0 Yes p53Scer\UAS.cPa in vitro construct - regulatory fusion 0 Yes p53Scer\UAS.P\T.cBa in vitro construct - regulatory fusion 0 Yes p53Scer\UAS.P\T.cCa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6193 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4483} NA P{GD11134} NA P{KK113065} NA P{TRiP.JF02513} NA P{UAS-p53.D259H} NA P{UAS-p53.J} NA P{UAS-p53.P} NA P{UAS-p53.RNAi} NA P{UAS-p53.S4A} NA P{UAS-p53.S20A} NA P{UASp-p53.B} NA P{UASp-p53RB.C} NA reporter construct P{p5'-p53.mutDREall-lacZ} No P{p5'-p53.wt-lacZ} No characterization construct P{ey3.5-p53.Exel} NA P{FRT(whs.p538.6.Scer\SceI.RS)} NA P{GMR-p53.Ex} NA P{GMR-p53.H159N.Ex} NA P{GMR-p53.R155H.Ex} NA P{GUS-p53.259H} NA P{GUS-p53.Ct} NA P{GUS-p53} NA P{p53.TV2} NA P{p53Scer\SceI.RS.cXa} NA P{sev-p53.Exel} NA P{UAS-p53.Ex} NA P{UAS-p53.H159N.Ex} NA P{UAS-p53.R155H.Ex} NA P{vgMQ-p53.Exel} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}p53EP-1 NA P{EPgy2}p53EY09278 NA P{EPgy2}p53EY14108 NA P{EPgy2}p53EY16724 NA miscellaneous insertions Mi{MIC}p53MI01307 NA PBac{RB}Gr94ae03459 NA
Gene Ontology: Function, Process & Cellular Component ( 28 unique terms )
Terms Based on Experimental Evidence ( 23 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with DLP (Bodai et al., 2007) inferred from physical interaction with UniProtKB:Q95SP2 (assigned by UniProtKB) (Yamasaki, 2007) transcription factor binding inferred from physical interaction with bip2 (Bereczki et al., 2008)
Biological Process
CV term Evidence References
activation of caspase activity inferred from mutant phenotype (Akdemir et al., 2007) apoptotic process inferred from mutant phenotype (McEwen and Peifer, 2005) cell death inferred from mutant phenotype (Sogame et al., 2003) determination of adult lifespan inferred from mutant phenotype (Bauer et al., 2005, Bauer et al., 2005) DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis inferred from mutant phenotype (Lee et al., 2003, Colombani et al., 2006, Brodsky et al., 2000) DNA damage response, signal transduction resulting in induction of apoptosis inferred from mutant phenotype (Moon et al., 2008) germ cell programmed cell death inferred from mutant phenotype (Bakhrat et al., 2010) negative regulation of photoreceptor cell differentiation inferred from mutant phenotype (Fan et al., 2010) oogenesis inferred from genetic interaction with okr (Lu et al., 2010) positive regulation of cell cycle inferred from genetic interaction with CoVa (Mandal et al., 2005) positive regulation of transcription, DNA-dependent inferred from direct assay (Brodsky et al., 2000) inferred from mutant phenotype (Bodai et al., 2007) reciprocal meiotic recombination inferred from mutant phenotype (Lu et al., 2010) regulation of cell proliferation inferred from mutant phenotype (Mesquita et al., 2010) regulation of organ growth inferred from mutant phenotype (Mesquita et al., 2010) response to DNA damage stimulus inferred from direct assay (Ravi et al., 2009) inferred from mutant phenotype (Jassim et al., 2003) response to ionizing radiation inferred from mutant phenotype (Bodai et al., 2007) response to radiation inferred from mutant phenotype (Sogame et al., 2003) response to UV inferred from mutant phenotype (Rebollar et al., 2006) tissue regeneration inferred from mutant phenotype (Wells et al., 2006)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Schauer et al., 2009) colocalizes_with transcriptionally active chromatin inferred from direct assay (Schauer et al., 2009)
Terms Based on Predictions or Assertions ( 9 terms )
Molecular Function
CV term Evidence References
DNA binding non-traceable author statement (FlyBase, 1992-) sequence-specific DNA binding transcription factor activity inferred from electronic annotation with InterPro:IPR002117, InterPro:IPR008967, InterPro:IPR012346 (FlyBase Curators et al., 2004-) non-traceable author statement (Brodsky, 2000.1.13) transcription regulatory region DNA binding inferred from electronic annotation with InterPro:IPR011615 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
apoptotic process traceable author statement (Richardson and Kumar, 2002, De Laurenzi and Melino, 2000) DNA damage response, signal transduction by p53 class mediator traceable author statement (Gorski and Marra, 2002, Richardson and Kumar, 2002) DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis traceable author statement (Walworth, 2000) DNA damage response, signal transduction resulting in induction of apoptosis traceable author statement (Gorski and Marra, 2002) regulation of transcription from RNA polymerase II promoter traceable author statement (Kumar, 2000) response to radiation traceable author statement (Kumar, 2000)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions p53 allele Gene References p5311-1B-1 mus201 (Jassim et al., 2003) p53GMR.Ex Myt1 (Price et al., 2002) wee (Price et al., 2002) p53GUS.PB hay (Merino et al., 2002) p53R155H.Scer\UAS.Ex tefu (Song et al., 2004) p53Scer\UAS.cPa lok (Peters et al., 2002) unspecified 14-3-3ζ (Mueller et al., 2005) Amun (Mueller et al., 2005) aop (Mueller et al., 2005) Arf72A (Mueller et al., 2005) ban (Mueller et al., 2005) CG5261 (Mueller et al., 2005) CG11779 (Mueller et al., 2005) CG32521 (Mueller et al., 2005) CoVa (Mandal et al., 2005) Dl (Mueller et al., 2005) dve (Mueller et al., 2005) Egfr (Mueller et al., 2005) elB (Mueller et al., 2005) grim (Mueller et al., 2005) H (Mueller et al., 2005) hep (Mueller et al., 2005) hpo (Colombani et al., 2006) Hr4 (Mueller et al., 2005) Imp (Mueller et al., 2005) klu (Mueller et al., 2005) lilli (Mueller et al., 2005) mir-278 (Mueller et al., 2005) N (Mueller et al., 2005) pnt (Mueller et al., 2005) puc (Mueller et al., 2005) rho (Mueller et al., 2005) Rho1 (Mueller et al., 2005) rpr (Mueller et al., 2005) sav (Colombani et al., 2006) Su(H) (Mueller et al., 2005) th (Mueller et al., 2005) tutl (Mueller et al., 2005) W (Mueller et al., 2005) wdb (Mueller et al., 2005) wg (Wells et al., 2006) wts (Colombani et al., 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 77545 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0039044 DroID - A comprehensive database of gene and protein interactions. • FBgn0039044 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 2768677
Orthologs
Genome-wide drosophilid orthologs	Dana\GF18271 Dere\GG12467 Dgri\GH18203 Dmoj\GI10763 Dper\GL27356 Dpse\GA27050 Dsec\GM23598 Dsim\GD18411 Dvir\GJ14364 Dwil\GK11606 Dyak\GE23990
Curated drosophilid orthologs
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • ENSCINP00000004447 Ciona intestinalis (sea squirt) CPIJ002758 Culex pipens (mosquito) ENSCSAVP00000016659 Ciona savignyi (sedentary tunicate) PHUM006027-PA Pediculus humanus (human body louse) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV12978 LH21233 ISCW018042 ISCW012889 FBgn0241132 FBgn0213617 FBgn0201577 FBgn0189936 FBgn0178463 JGI_V11_304717 FBgn0248421 FBgn0164937 FBgn0133526 FBgn0125671 FBgn0104755 FBgn0095289 CPIJ002764 BGIBMGA013185 ACYPI51115 ACYPI42272 ACYPI002015 GB11330 AGAP002352 AAEL013292 AAEL007594 PB25804 PHUM003140 GLEAN_11560 GLEAN_11559
Stocks & Reagents
Stocks Listed in FlyBase ( 33 )
Bloomington	6584 w1118; P{GUS-p53}2.1 9170 w1118; P{UAS-p53.Ex}2 6582 w1118; P{GUS-p53.259H}3.1 8432 y1 w1118; P{sev-p53.Exel}2 8433 P{sev-p53.Exel}1, y1 w1118 8429 P{vgMQ-p53.Exel}1, y1 w1118 8430 y1 w1118; P{vgMQ-p53.Exel}3
VDRC	v103001 P{KK113065}VIE-260B v10692 w1118; P{GD4483}v10692 v38235 w1118; P{GD4483}v38235 v45138 w1118; P{GD11134}v45138 v45139 w1118; P{GD11134}v45139
	More stocks available...
Genomic Clones ( 2 )
	BACR01K08 BACR17P04 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 58 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT28346 GH11591
Other clones	DPiM_AT28346 DPiM_GH11591 MIP21145
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH08710 GH28349 LD03645 LD31553 LD35041 LD38321 LD41269 LD42031 LD42237 SD26348
Other clones	44018 153987 180757 EC051771 EC053758 EC056252 EK257513 EK258606 RP003023598 RP003077523 RP003089268 RP003157282 RP003161286 RP003260493 RP003264386 RP003414985 RP003436727 RP003500144 RP003538287 RP003556622 RP003569200 RP003578352 RP003615929 RP003627033 RP003641438 RP003652558 RP003657391 RP003665974 RP003668913 RP003676876 RP003681516 RP003682361 RP004094239 RP004164195 RP004189785 RP004203273 RP004211593 RP004215039 RP004240582 RP004388226 RP004436668 RP004490097 RP004532662
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0039044 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42722 318683
Antibody Information
	monoclonal (Ollmann et al., 2000) polyclonal (Brodsky et al., 2000, Ollmann et al., 2000)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: p53 CG10873 (FlyBase Genome Annotators, 2004, FlyBase, 1996-)
Additional comments	Source for merge of p53 CG10873 was sequence comparison (date:000401). (FlyBase Genome Annotators, 2004, FlyBase, 1996-)
Other Comments
	p53 mediates the coordination of tissue growth; when growth rate is reduced in a specific territory in the developing wing disc, both growth and proliferation rates are regulated in a coordinated and non-autonomous manner by activation of p53 in the growth-depleted territory. (Mesquita et al., 2010) Kc cells have been treated with dsRNA made from templates generated with primers directed against this gene to study the how p53 RNAi affects phosphorylation of the hpo product. (Colombani et al., 2006) Kc cells have been treated with dsRNA made from templates generated with primers directed against this gene. (Colombani et al., 2006) p53 is dispensable for lkb1-dependent apoptosis and vice versa. (Lee et al., 2006) p53 protects the retina during developmentally regulated DNA damage response. (Jassim et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Mutants are defective in irradiation-dependent caspase activation and do not show irradiation induced apoptosis. (Lee et al., 2003) p53 has a role in cell death and in the adaptive response to maintain genomic stability. (Sogame et al., 2003) New annotation (CG31325) in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) p53 protein binds a damage response element at the rpr locus. rpr is a direct transcriptional target of p53 following DNA damage. (Brodsky et al., 2000) p53 is required for the apoptotic response to DNA damage. (Ollmann et al., 2000) Overexpression of p53 induces apoptosis (but does not induce G1 cell cycle block). Inhibition of p53 function renders cells resistant to X-ray induced apoptosis and does not affect X-ray induced cell cycle arrest. (Ollmann et al., 2000)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_206544 NM_206545 NM_001170223 RefSeq (Proteins) • NP_996267 NP_996268 NP_001163694 DDBJ / EMBL / GenBank • AAF40427 AAF40428 AAF56087 AAF61572 AAF74277 AAF75270 AAL39241 AAL56639 AAN13925 AAN71112 ABB80263 ABB80264 ABB80265 AC008200 ACZ94989 AF192555 AF224713 AF224714 AF244918 AF250918 AF263722 AI061944 AI134202 AW940417 AY069096 BF491571 BT001357 CL526095 CL943607 DQ191318 DQ191319 DQ191320 Entrez Gene - A searchable database of RefSeq genes. • 2768677 UniProtKB/TrEMBL • Q2XVY6 Q2XVY7 Q8IH92 Q8IMZ4 Q9N6D8
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • p53-like transcription factor, DNA-binding (IPR008967) p53, DNA-binding domain (IPR011615) p53/RUNT-type transcription factor, DNA-binding domain (IPR012346) Transcription factor p53, C-terminal, Drosophila (IPR024631) p53 tumour suppressor family (IPR002117)
Linkouts
	BioGRID - A database of protein and genetic interactions • 77545 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0039044 DroID - A comprehensive database of gene and protein interactions. • FBgn0039044 DRSC - Results from RNAi screens. • FBgn0039044 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039044 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10873-RA;CG31325-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0039044 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42722 318683 InParanoid A subset of ortholog calls from InParanoid. • ENSCINP00000004447 Ciona intestinalis (sea squirt) CPIJ002758 Culex pipens (mosquito) ENSCSAVP00000016659 Ciona savignyi (sedentary tunicate) PHUM006027-PA Pediculus humanus (human body louse) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /hjmuller/p53-1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 2768677 modMine - Data generated by the modENCODE project. • FBgn0039044 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV12978 LH21233 ISCW018042 ISCW012889 FBgn0241132 FBgn0213617 FBgn0201577 FBgn0189936 FBgn0178463 JGI_V11_304717 FBgn0248421 FBgn0164937 FBgn0133526 FBgn0125671 FBgn0104755 FBgn0095289 CPIJ002764 BGIBMGA013185 ACYPI51115 ACYPI42272 ACYPI002015 GB11330 AGAP002352 AAEL013292 AAEL007594 PB25804 PHUM003140 GLEAN_11560 GLEAN_11559
Synonyms & Secondary IDs ( 15 )
Reported As
Symbol Synonym	CG10873 (Brodsky, 2000.3.25, Potter, 2000.3.12, ) CG31325   CG33336 (Keleman et al., 2009.8.5, Perkins et al., 2009, Trong-Tue et al., 2010) Dmp53 (Mueller et al., 2005, Song et al., 2004, Kusch et al., 2003, Kumar and Cakouros, 2004, Secombe and Parkhurst, 2004, Jassim et al., 2003, Lee et al., 2003, Merino et al., 2002, Sogame et al., 2003, Claveria and Torres, 2003, Peters et al., 2002, Sogame et al., 2003, Christich et al., 2003, Richardson and Kumar, 2002, Gorski and Marra, 2002, Taylor et al., 2001, White et al., 2001, Steller, 2000, Pankotai et al., 2005, O'Keefe et al., 2006, Bauer et al., 2007, Bauer et al., 2005, Colombani et al., 2006, Rebollar et al., 2006, Peterson et al., 2007, Park et al., 2003, Bodai et al., 2007, Pankotai et al., 2005, Kondo et al., 2006, Bauer et al., 2007, Der Ou et al., 2007, Yamasaki, 2007, Morey et al., 2003, Schauer et al., 2009, Bereczki et al., 2008, Palomera-Sanchez et al., 2010, Bakhrat et al., 2010, Joza et al., 2008) DmP53 (Morey et al., 2003, Zhang et al., 2008) dmp53 (Sutcliffe and Brehm, 2004, Bangs et al., 2000, Fan and Bergmann, 2007, Trong-Tue et al., 2010, Brun et al., 2002, Tue et al., 2011) Dm-P53 (Gorski and Marra, 2002) dp53 (Bourdon, 2005, Mills, 2005, Dai et al., 2004, Van Hoof and Goris, 2003, Pieper et al., 2002, Jin et al., 2000, Wells and Johnston, 2007, Wells et al., 2006, Garcia et al., 2007, Li et al., 2002, Mesquita et al., 2010, Moon et al., 2008, Montero et al., 2008, Mendes et al., 2009, Nicholson et al., 2009, Morris et al., 2006) Dp53 (Akdemir et al., 2007, Fan et al., 2010, Suissa et al., 2011) D-p53 (Allton et al., 2009) p53 (Singh et al., 2006, Abraham et al., 2007, Bauer et al., 2007, Wichmann et al., 2007, Wichmann et al., 2006, Bauer et al., 2005, McEwen and Peifer, 2005, McBride et al., 2006, Colombani et al., 2006, Colombani et al., 2006, Hochwagen, 2006, Mukherjee et al., 2006, Bruckner et al., 2004, Sidorov et al., 2003, Bae et al., 2005, Lin and Beal, 2006, Tountas and Fortini, 2007, Lunardi et al., 2010, Gullaud et al., 2003, Mandal et al., 2005, Baehrecke, 2006, LaRocque et al., 2007, McNamee and Brodsky, 2008, Brodsky et al., 2004, Gan et al., 2010, Yamada et al., 2008, Jager et al., 2005, Akdemir et al., 2007, Oikemus et al., 2006, Moon et al., 2008, Bauer et al., 2007, Luo et al., 2007, Fan and Bergmann, 2008, Mehrotra et al., 2008, Chandraratna et al., 2007, Titen and Golic, 2008, Jaklevic et al., 2008, Lee et al., 2010, Buchon et al., 2009, Peng and Karpen, 2009, Brun et al., 2006, Lee et al., 2006, Hong et al., 2009, Maezawa et al., 2009, Ravi et al., 2009, Jiang et al., 2009, Qian and Bodmer, 2009, Owusu-Ansah et al., 2008, Liu et al., 2008, Grewal et al., 2007, Morris et al., 2006, Marhold et al., 2004, Bereczki et al., 2008, Mandal et al., 2010, Lu et al., 2010, Shen et al., 2009, Folberg-Blum et al., 2002, Tue et al., 2011, Terashima and Bownes, 2005, Juhasz and Sass, 2005, Edwards et al., 2011, Pedersen et al., 2010, Kim et al., 2010) prac (Inohara, 1999.10.6)
Name Synonym	Dmp53 (Peterson et al., 2007) Drosophila p53 (Fan et al., 2010) p53 (Bae et al., 2005, Gullaud et al., 2003, Moon et al., 2008, Terashima and Bownes, 2005) p53-like regulator of apoptosis and cell cycle (Inohara, 1999.10.6) protein 53 (Kim et al., 2010)
Secondary FlyBase IDs
	FBgn0051325 FBgn0053336
References ( 196 )
Generate a list of	All references relating to this gene ( 196 )
List References by type	Research paper  ( 119 ) Supplementary material  ( 7 ) Review  ( 24 ) Personal communication to FlyBase  ( 11 ) Abstract  ( 20 ) FlyBase analysis  ( 4 ) DNA/RNA sequence record  ( 5 ) Conference report  ( 2 ) Computer file  ( 2 ) Curated genome annotation  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 19 )
	Edwards et al., 2011, Dis. Model Mech. 4(4): 496--503 Combinatorial effect of maytansinol and radiation in Drosophila and human cancer cells. [FBrf0214017] Marinho et al., 2011, Development 138(2): 349--357 The Drosophila Nol12 homologue viriato is a dMyc target that regulates nucleolar architecture and is required for dMyc-stimulated cell growth. [FBrf0212565] Moskalev et al., 2011, Biogerontology 12(3): 253--263 Radiation hormesis and radioadaptive response in Drosophila melanogaster flies with different genetic backgrounds: the role of cellular stress-resistance mechanisms. [FBrf0213740] Suissa et al., 2011, J. Biol. Chem. 286(17): 15556--15564 The NAB-Brk Signal Bifurcates at JNK to Independently Induce Apoptosis and Compensatory Proliferation. [FBrf0213516] Tue et al., 2011, Gene 473(1): 1--7 NF-Y transcriptionally regulates the Drosophila p53 gene. [FBrf0212943] Bakhrat et al., 2010, Apoptosis 15(12): 1425--1434 Drosophila Chk2 and p53 proteins induce stage-specific cell death independently during oogenesis. [FBrf0212376] Fan et al., 2010, Cell Death Differ. 17(6): 912--921 Dual roles of Drosophila p53 in cell death and cell differentiation. [FBrf0210741] Gan et al., 2010, Cell Res. 20(7): 763--783 Dynamic regulation of alternative splicing and chromatin structure in Drosophila gonads revealed by RNA-seq. [FBrf0211191] Kim et al., 2010, Exp. Gerontol. 45(12): 984--987 Enhancement of stress resistances and downregulation of Imd pathway by lower developmental temperature in Drosophila melanogaster. [FBrf0212401] Lee et al., 2010, Science 327(5970): 1223--1228 Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. [FBrf0210161] Lu et al., 2010, Science 328(5983): 1278--1281 Meiotic recombination provokes functional activation of the p53 regulatory network. [FBrf0210965] Lunardi et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(14): 6322--6327 A genome-scale protein interaction profile of Drosophila p53 uncovers additional nodes of the human p53 network. [FBrf0210534] Mandal et al., 2010, J. Cell Biol. 188(4): 473--479 Metabolic control of G1-S transition: cyclin E degradation by p53-induced activation of the ubiquitin-proteasome system. [FBrf0210063] Mesquita et al., 2010, PLoS Biol. 8(12): e1000566 A dp53-Dependent Mechanism Involved in Coordinating Tissue Growth in Drosophila. [FBrf0212630] Palomera-Sanchez et al., 2010, J. Biol. Chem. 285(41): 31370--31379 Drosophila p53 Is Required to Increase the Levels of the dKDM4B Demethylase after UV-induced DNA Damage to Demethylate Histone H3 Lysine 9. [FBrf0211957] Pedersen et al., 2010, Genome 53(10): 778--786 Molecular genetic characterization of Drosophila ATM conserved functional domains. [FBrf0212143] Shen and Tower, 2010, Exp. Gerontol. 45(2): 97--105 Drosophila foxo acts in males to cause sexual-dimorphism in tissue-specific p53 life span effects. [FBrf0209844] Trong-Tue et al., 2010, Oncogene 29(14): 2060--2069 Role of DREF in transcriptional regulation of the Drosophila p53 gene. [FBrf0210535] Wichmann et al., 2010, Dev. Biol. 346(1): 80--89 E2F1 and E2F2 have opposite effects on radiation-induced p53-independent apoptosis in Drosophila. [FBrf0211749] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...