FB2025_02 , released April 17, 2025
Gene: Dmel\p53
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General Information
Symbol
Dmel\p53
Species
D. melanogaster
Name
p53
Annotation Symbol
CG33336
Feature Type
protein_coding_gene
FlyBase ID
FBgn0039044
Gene Model Status
Current
Stock Availability
43 publicly available
Gene Summary
p53 (p53) encodes a transcriptional factor required for adaptive responses to genotoxic stress, including cell death, compensatory proliferation and DNA repair. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Dmp53, dp53

Key Links
Genomic Location
Cytogenetic map
94D10-94D10
Sequence location
Recombination map
3-77
RefSeq locus
NT_033777 REGION:23049657..23054082
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (52 terms)
Molecular Function (12 terms)
Terms Based on Experimental Evidence (8 terms)
CV Term
Evidence
References
enables promoter-specific chromatin binding
inferred from direct assay
(Zhang et al., 2013)
enables protein binding
inferred from physical interaction with FLYBASE:Daxx; FB:FBgn0031820
(Bodai et al., 2007)
inferred from physical interaction with UniProtKB:Q95SP2
(Yamasaki et al., 2007)
enables RNA polymerase II general transcription initiation factor binding
inferred from physical interaction with FLYBASE:Taf3; FB:FBgn0026262
(Bereczki et al., 2008)
enables RNA polymerase II-specific DNA-binding transcription factor binding
inferred from physical interaction with UniProtKB:Q9V4D4
(Bereczki et al., 2008)
enables TFIIH-class transcription factor complex binding
inferred from physical interaction with FLYBASE:mrn; FB:FBgn0261109
(Villicaña et al., 2013)
enables transcription cis-regulatory region binding
inferred from direct assay
(Merlo et al., 2014)
enables ubiquitin conjugating enzyme binding
inferred from physical interaction with FLYBASE:Ubc6; FB:FBgn0004436
(Chen et al., 2011)
enables ubiquitin protein ligase binding
inferred from physical interaction with FLYBASE:sip3; FB:FBgn0039875
(Yamasaki et al., 2007)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
enables DNA binding
inferred from electronic annotation with InterPro:IPR002117, InterPro:IPR012346
(InterPro Project Members, 2004-)
enables DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from biological aspect of ancestor with PANTHER:PTN000893833
(GO Reference Genome Project, 2011-)
enables DNA-binding transcription factor activity
inferred from electronic annotation with InterPro:IPR002117, InterPro:IPR008967, InterPro:IPR012346
(InterPro Project Members, 2004-)
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN000893833
(GO Reference Genome Project, 2011-)
enables transcription cis-regulatory region binding
inferred from electronic annotation with InterPro:IPR011615
(InterPro Project Members, 2004-)
Biological Process (37 terms)
Terms Based on Experimental Evidence (35 terms)
CV Term
Evidence
References
involved_in apoptotic process
inferred from mutant phenotype
(McEwen and Peifer, 2005, Sogame et al., 2003)
involved_in cellular response to gamma radiation
inferred from mutant phenotype
(D'Brot et al., 2017, Zhang et al., 2013)
inferred from mutant phenotype
(Peters et al., 2002)
involved_in cellular response to starvation
inferred from mutant phenotype
(Hasygar and Hietakangas, 2014, Hou et al., 2008)
involved_in determination of adult lifespan
inferred from mutant phenotype
(Bauer et al., 2005)
inferred from mutant phenotype
(Bauer et al., 2007)
involved_in DNA damage response
inferred from mutant phenotype
(Jassim et al., 2003)
involved_in ectopic germ cell programmed cell death
inferred from mutant phenotype
(Bakhrat et al., 2010)
involved_in intrinsic apoptotic signaling pathway by p53 class mediator
inferred from mutant phenotype
(Peters et al., 2002)
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
inferred from genetic interaction with UniProtKB:P25153
(Chen et al., 2011)
inferred from mutant phenotype
(Zhang et al., 2015, Colombani et al., 2006, Lee et al., 2003, Brodsky et al., 2000)
inferred from mutant phenotype
(Peters et al., 2002)
involved_in intrinsic apoptotic signaling pathway in response to DNA damage
inferred from mutant phenotype
(Moon et al., 2008, Akdemir et al., 2007)
involved_in negative regulation of insulin-like growth factor receptor signaling pathway
inferred from mutant phenotype
(Bauer et al., 2007)
involved_in negative regulation of photoreceptor cell differentiation
inferred from mutant phenotype
(Fan et al., 2010)
involved_in neuroblast differentiation
inferred from mutant phenotype
(Ouyang et al., 2011)
involved_in neuroblast proliferation
inferred from mutant phenotype
(Ouyang et al., 2011)
involved_in oogenesis
inferred from genetic interaction with FLYBASE:okr; FB:FBgn0002989
(Lu et al., 2010)
involved_in positive regulation of cell cycle
inferred from genetic interaction with FLYBASE:COX5A; FB:FBgn0019624
(Mandal et al., 2005)
involved_in positive regulation of cellular response to X-ray
inferred from mutant phenotype
(Brodsky et al., 2004)
involved_in positive regulation of DNA-templated transcription
inferred from mutant phenotype
(Zhang et al., 2013, Bodai et al., 2007)
inferred from direct assay
(Brodsky et al., 2000)
involved_in positive regulation of gene expression
inferred from mutant phenotype
(D'Brot et al., 2017)
involved_in positive regulation of growth rate
inferred from mutant phenotype
(Bauer et al., 2007)
involved_in positive regulation of macroautophagy
inferred from mutant phenotype
(Hou et al., 2008)
involved_in positive regulation of multicellular organism growth
inferred from mutant phenotype
(Bauer et al., 2007)
acts_upstream_of positive regulation of programmed necrotic cell death
inferred from mutant phenotype
(Napoletano et al., 2017)
involved_in positive regulation of protein import into nucleus
inferred from mutant phenotype
(Bauer et al., 2007)
involved_in positive regulation of transcription by RNA polymerase II
inferred from mutant phenotype
(Bauer et al., 2007, Peters et al., 2002)
involved_in reciprocal meiotic recombination
inferred from mutant phenotype
(Lu et al., 2010)
involved_in regulation of apoptosis involved in tissue homeostasis
inferred from mutant phenotype
(Zhang et al., 2015)
involved_in regulation of cell population proliferation
inferred from mutant phenotype
(Mesquita et al., 2010)
involved_in regulation of DNA repair
inferred from mutant phenotype
(Brodsky et al., 2004)
involved_in regulation of organ growth
inferred from mutant phenotype
(Mesquita et al., 2010)
involved_in regulation of transcription by RNA polymerase II
inferred from mutant phenotype
(Zhang et al., 2014)
involved_in response to ionizing radiation
inferred from mutant phenotype
(Zhang et al., 2015, Link et al., 2013, Bodai et al., 2007)
involved_in response to radiation
inferred from mutant phenotype
(Sogame et al., 2003)
involved_in response to starvation
inferred from mutant phenotype
(Barrio et al., 2014)
involved_in response to UV
inferred from mutant phenotype
(Rebollar et al., 2006)
involved_in tissue regeneration
inferred from mutant phenotype
(Wells et al., 2006)
Terms Based on Predictions or Assertions (7 terms)
CV Term
Evidence
References
involved_in apoptotic process
inferred from electronic annotation with InterPro:IPR002117
(InterPro Project Members, 2004-)
traceable author statement
(De Laurenzi and Melino, 2000)
involved_in DNA damage response, signal transduction by p53 class mediator
traceable author statement
(Gorski and Marra, 2002)
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
traceable author statement
(Walworth, 2000)
involved_in intrinsic apoptotic signaling pathway in response to DNA damage
traceable author statement
(Gorski and Marra, 2002)
involved_in regulation of DNA-templated transcription
inferred from electronic annotation with InterPro:IPR002117, InterPro:IPR008967, InterPro:IPR012346
(InterPro Project Members, 2004-)
involved_in regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN000893833
(GO Reference Genome Project, 2011-)
traceable author statement
(Kumar, 2000)
involved_in response to radiation
traceable author statement
(Kumar, 2000)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
colocalizes_with chromocenter
inferred from direct assay
(Zhang et al., 2015)
colocalizes_with euchromatin
inferred from direct assay
(Schauer et al., 2009)
located_in nucleus
inferred from high throughput direct assay
(Sarov et al., 2016)
inferred from direct assay
(Schauer et al., 2009)
inferred from mutant phenotype
(D'Brot et al., 2017)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in nucleus
inferred from electronic annotation with InterPro:IPR002117, InterPro:IPR012346
(InterPro Project Members, 2004-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
p53 (p53) encodes a transcriptional factor required for adaptive responses to genotoxic stress, including cell death, compensatory proliferation and DNA repair. [Date last reviewed: 2019-03-14]
Gene Group (FlyBase)
UNCLASSIFIED DNA BINDING DOMAIN TRANSCRIPTION FACTORS -
This group comprises DNA-binding transcription factors that do not classify under other domain-based transcription factor groups in FlyBase.
Summary (Interactive Fly)

DNA repair pathway and apoptosis transcription factor - restricts retrotransposon activity and genetically interacts with components of the piRNA pathway

Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\p53 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q8IMZ4)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
PDB - An information portal to biological macromolecular structures
Comments on Gene Model

Gene model reviewed during 5.48

Gene model reviewed during 5.39

Gene model reviewed during 5.55

Low-frequency RNA-Seq exon junction(s) not annotated.

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
p53-RA
FBtr0084359
NM_206545
1577
385
p53-RB
FBtr0084360
NM_206544
1870
495
p53-RC
FBtr0301765
NM_001170223
2095
385
p53-RE
FBtr0345262
NM_001260323
1324
334
Additional Transcript Data and Comments
Reported size (kB)

1.523 (longest cDNA)

(Brodsky et al., 2000)

1.381 (longest cDNA)

(Jin et al., 2000)

1.6 (northern blot)

(Ollmann et al., 2000)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
p53-PA
FBpp0083752
43.7
385
7.30
Q9N6D8
NP_996268
AAF56087
p53-PB
FBpp0083753
55.6
495
6.69
Q8IMZ4
NP_996267
AAN13925
p53-PC
FBpp0290979
43.7
385
7.30
Q9N6D8
NP_001163694
ACZ94989
p53-PE
FBpp0311439
38.2
334
8.93
A0A0B4K7P1
NP_001247252
AFH06570
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

385 aa isoforms: p53-PA, p53-PC
Additional Polypeptide Data and Comments
Reported size (kDa)

385 (aa)

(Brodsky et al., 2000, Jin et al., 2000, Ollmann et al., 2000)
Comments

Drosophila p53 protein binds the human p53 protein binding sites in the human p21 and GACC45 genes. Overexpression of Drosophila p53 protein induces apoptosis but not G1 arrest. X-ray induced apoptosis is blocked upon expression of a mutant form of p53 protein that has dominant-negative activity. p53-related genes are present in other insects (Tribolium castaneum and Leptinotarsa decemlineata EST projects).

(Jin et al., 2000)
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
PDB - An information portal to biological macromolecular structures
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\p53 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.55

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 1 -- 4
organism | uniform

Comment: maternally deposited; NOT pole cell

(Ollmann et al., 2000)
embryonic stage 1 -- 5
organism | ubiquitous

Comment: maternal contribution

(Jin et al., 2000)
embryonic stage 1 -- 9
primordial germ cell
(Maezawa et al., 2009)
embryonic stage 4 -- 6
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 6 -- 13
organism | ubiquitous
(Jin et al., 2000)
embryonic stage 7 -- 8
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
germline cell
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 10
mesoderm
(Ollmann et al., 2000)
foregut primordium
(Ollmann et al., 2000)
anterior midgut primordium
(Ollmann et al., 2000)
hindgut proper primordium
(Ollmann et al., 2000)
posterior midgut primordium
(Ollmann et al., 2000)
embryonic stage 11 -- 12
germline cell
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
germline cell
(Fisher et al., 2012)
gonad
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 16
germline cell
(Ollmann et al., 2000)
embryonic/larval hindgut | restricted

Comment: small patch of cells

(Ollmann et al., 2000)
oogenesis stage S10 & adult stage | female
nurse cell

Comment: undetectable in follicle cells

(Jin et al., 2000, Ollmann et al., 2000)
adult stage | female & oogenesis stage S10
oocyte
(Ollmann et al., 2000)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
(Ollmann et al., 2000)
embryonic stage 10
mesoderm
(Ollmann et al., 2000)
embryonic/larval midgut
(Ollmann et al., 2000)
embryonic/larval hindgut
(Ollmann et al., 2000)
embryonic/larval foregut
(Ollmann et al., 2000)
embryonic stage 16
embryonic/larval hindgut | restricted
(Ollmann et al., 2000)
larval stage
(Ollmann et al., 2000)
adult stage
(Ollmann et al., 2000)
adult stage & oogenesis stage S10
oocyte
(Ollmann et al., 2000)
nurse cell
(Ollmann et al., 2000)
RNase protection, primer extension, SI map
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
(Jin et al., 2000)
embryonic stage -- adult stage
(Jin et al., 2000)
adult stage | female
(Jin et al., 2000)
adult stage & oogenesis stage S10
nurse cell
(Jin et al., 2000)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
colocalizes_with chromocenter
inferred from direct assay
(Zhang et al., 2015)
colocalizes_with euchromatin
inferred from direct assay
(Schauer et al., 2009)
located_in nucleus
inferred from high throughput direct assay
(Sarov et al., 2016)
inferred from direct assay
(Schauer et al., 2009)
inferred from mutant phenotype
(D'Brot et al., 2017)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\p53 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 25 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 65 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of p53
Transgenic constructs containing regulatory region of p53
Aberrations (Deficiencies and Duplications) ( 2 )
Inferred from experimentation ( 2 )
Gene disrupted in
Df(3R)Exel6193
(Ryder, 2004.4.26)
Gene partially disrupted in
In(3LR)TM3-3
(Miller et al., 2016)
Inferred from location ( 9 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4Act5C.PU
lethal, with Scer\GAL4elav-C155
lethal | male limited, with Scer\GAL4Bx-MS1096
lethal | male limited | cold sensitive, with Scer\GAL4Bx-MS1096
lethal - all die before end of pupal stage
partially lethal - majority die, with Scer\GAL4Act5C.PI
partially lethal - majority die | pupal stage, with Scer\GAL4da.G32
partially lethal - majority die | third instar larval stage, with Scer\GAL4da.G32
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female semi-fertile
female semi-sterile
fertile
semi-sterile
Other Phenotypes
Allele
abnormal cell death
abnormal cell death | conditional
abnormal cell number | embryonic stage
abnormal cell number | embryonic stage, with Scer\GAL4VP16.nanos.UTR
abnormal developmental rate, with Scer\GAL4Ilp2.PR
abnormal DNA repair | oogenesis
abnormal immune response | adult stage
abnormal meiotic cell cycle | spermatogenesis
abnormal mitotic cell cycle
abnormal neuroanatomy | larval stage, with Scer\GAL4wor.PA
abnormal size, with Scer\GAL4GMR.PF
abnormal size | adult stage
abnormal size | adult stage, with Scer\GAL4GMR.PF
abnormal size | adult stage, with Scer\GAL4GMR.PU
abnormal size | larval stage, with Scer\GAL4sd.PU
abnormal starvation stress response
abnormal starvation stress response, with Scer\GAL4Cg.PU
abnormal starvation stress response, with Scer\GAL4ppl.PP
abnormal starvation stress response, with Scer\GAL4yolk
chemical resistant, with Scer\GAL4ple.PF
chemical resistant | RU486 conditional, with Scer\GAL4elav.Switch.PO
chemical sensitive
chemical sensitive | adult stage
decreased body size | pupal stage, with Scer\GAL4Ilp2.PR
decreased cell death
decreased cell death, with Scer\GAL4en-e16E
decreased cell death, with Scer\GAL4GMR.PF
decreased cell death | embryonic stage | conditional (with p53-ns)
decreased cell death | embryonic stage | conditional (with p53TM3)
decreased cell death | heat sensitive, with Scer\GAL4hs.PU
decreased cell death | larval stage | conditional
decreased cell death | larval stage | conditional (with p53-ns)
decreased cell death | larval stage | conditional (with p53TM3)
decreased cell death | oogenesis
decreased cell death | recessive
decreased cell death | spermatogenesis
decreased cell death | spermatogenesis, with Scer\GAL4nanos.PU
decreased cell death | third instar larval stage | conditional
decreased cell number, with Scer\GAL4VP16.nanos.UTR
decreased cell number | adult stage, with Scer\GAL4ninaE.PT
decreased cell number | adult stage | female | conditional
decreased cell number | oogenesis, with Scer\GAL4nanos.PG
decreased cell number | pupal stage
decreased cell number | pupal stage | somatic clone, with Scer\GAL4GMR.PU
decreased cell number | third instar larval stage
decreased cell number | third instar larval stage, with Scer\GAL4GMR.PU
decreased fecundity, with Scer\GAL4VP16.nanos.UTR, p535A-1-4
decreased fecundity, with Scer\GAL4VP16.nanos.UTR, p53UASp.A
decreased fecundity | conditional
decreased size | adult stage
decreased size | adult stage, with Scer\GAL4GMR.PF
hyperplasia | larval stage, with Scer\GAL4Bx-MS1096
hyperplasia | recessive | spermatogenesis
hyperplasia | spermatogenesis
hyperplasia | spermatogenesis, with Scer\GAL4nanos.PU
increased cell death
increased cell death, with Scer\GAL4Bx-MS1096
increased cell death, with Scer\GAL4Bx-MS1096, p535A-1-4
increased cell death, with Scer\GAL4Bx-MS1096, p53UAS.Dp53
increased cell death, with Scer\GAL4Bx-MS1096, p53UAS.DΔNp53
increased cell death, with Scer\GAL4en-e16E
increased cell death, with Scer\GAL4fkh.PH
increased cell death, with Scer\GAL4GMR.PF
increased cell death, with Scer\GAL4GMR.PU
increased cell death, with Scer\GAL4hs.PU
increased cell death | adult stage
increased cell death | adult stage, with Scer\GAL4ninaE.PT
increased cell death | adult stage | chemical conditional
increased cell death | adult stage | heat sensitive, with Scer\GAL4hs.PU
increased cell death | conditional
increased cell death | germline clone, with Scer\GAL4GR1
increased cell death | germline clone, with Scer\GAL4VP16.nanos.UTR
increased cell death | larval stage, with Scer\GAL4hh.PU
increased cell death | larval stage, with Scer\GAL4sd.PU
increased cell death | oogenesis
increased cell death | third instar larval stage
increased cell death | third instar larval stage, with Scer\GAL4en.PU
increased cell death | third instar larval stage, with Scer\GAL4GMR.PU
increased cell death | third instar larval stage, with Scer\GAL4hh.PU
increased cell number | embryonic stage
increased cell size | somatic clone
increased mortality | adult stage | conditional
increased occurrence of cell division | larval stage, with Scer\GAL4Bx-MS1096
increased occurrence of cell division | larval stage, with Scer\GAL4sd.PU
long lived, with Scer\GAL4elav-C155
long lived | female | RU486 conditional, with Scer\GAL4Act5C.Switch.PR
long lived | RU486 conditional, with Scer\GAL4elav.Switch.PO
majority die during embryonic stage | maternal effect
neoplasia | larval stage, with Scer\GAL4sd.PU
radiation resistant
radiation resistant | oogenesis
radiation sensitive
radiation sensitive | third instar larval stage
short lived
short lived | chemical conditional
some die during embryonic stage | maternal effect
visible
visible, with Scer\GAL4Bx-MS1096
visible, with Scer\GAL4GMR.PF
visible, with Scer\GAL4GMR.PU
visible | adult stage
visible | adult stage, with Scer\GAL4en.PU
visible | adult stage, with Scer\GAL4GMR.PF
visible | adult stage, with Scer\GAL4GMR.PU
visible | adult stage, with Scer\GAL4nub-AC-62
visible | adult stage, with Scer\GAL4sd.PU
visible | female limited, with Scer\GAL4Bx-MS1096
visible | female limited | cold sensitive, with Scer\GAL4Bx-MS1096
visible | maternal effect
wild-type
Phenotype manifest in
Allele
adult | chemical conditional
adult brain | chemical conditional
adult fat body | nutrition conditional, with Scer\GAL4ppl.PP
adult heart, with Scer\GAL4tin.CΔ4
adult heart muscle cell, with Scer\GAL4tin.CΔ4
autolysosome, with Scer\GAL4ninaE.PT
autophagosome, with Scer\GAL4ninaE.PT
autophagosome | increased number, with Scer\GAL4ninaE.PT
cardiac myofibril | adult stage, with Scer\GAL4tin.CΔ4
cone cell | pupal stage
cone cell | third instar larval stage
cystic bulge
dorsal-ventral compartment boundary of the wing disc, with Scer\GAL4sd.PU
egg | maternal effect
egg chamber, with Scer\GAL4GR1
eye
eye, with Scer\GAL4ey.PH
eye, with Scer\GAL4ey.PU
eye, with Scer\GAL4GMR.PF
eye, with Scer\GAL4GMR.PU
eye | conditional
eye disc
eye disc, with Scer\GAL4GMR.PF
eye disc, with Scer\GAL4GMR.PU
eye disc | conditional
eye disc | posterior | third instar larval stage
eye disc | posterior | third instar larval stage, with Scer\GAL4GMR.PU
eye disc | pupal stage
eye disc | third instar larval stage, with Scer\GAL4GMR.PU
eye photoreceptor cell, with Scer\GAL4ninaE.PT
female germline cell
female germline cell | decreased number, with Scer\GAL4nanos.PG
female germline cell | oogenesis
female germline cyst, with Scer\GAL4nanos.PG
female germline stem cell | adult stage | conditional
follicle cell
follicle cell | heat sensitive, with Scer\GAL4hs.PU
follicle cell | oogenesis stage S8, with Scer\GAL4hs.PU
germarium, with Scer\GAL4nanos.PG
germarium | oogenesis
germline cell, with Scer\GAL4VP16.nanos.UTR
imaginal disc, with Scer\GAL4hs.PU
imaginal disc | third instar larval stage
interommatidial bristle
interommatidial bristle, with Scer\GAL4GMR.PF
interommatidial bristle, with Scer\GAL4GMR.PU
larval neuroblast | larval stage | conditional
lipid droplet | nutrition conditional, with Scer\GAL4ppl.PP
mitochondrion | somatic clone
neuroblast, with Scer\GAL4insc-Mz1407
neuroblast | larval stage, with Scer\GAL4wor.PA
nurse cell
ommatidium
ommatidium, with Scer\GAL4GMR.PF
ommatidium, with Scer\GAL4GMR.PU
ommatidium | pupal stage
ommatidium | pupal stage | somatic clone, with Scer\GAL4GMR.PU
onion stage spermatid
oocyte
oocyte | oogenesis stage S2
oocyte | oogenesis stage S2 (with p532)
oocyte | oogenesis stage S2 (with p5311-1B-1)
oocyte | oogenesis stage S2 (with p53-ns)
outer photoreceptor cell
ovary, with Scer\GAL4VP16.nanos.UTR
photoreceptor cell R7 | pupal stage | somatic clone, with Scer\GAL4GMR.PU
photoreceptor cell R7 | third instar larval stage
photoreceptor cell R7 | third instar larval stage, with Scer\GAL4GMR.PU
primordial germ cell
primordial germ cell (with p535A-1-4)
primordial germ cell (with p53-ns)
primordial germ cell | embryonic stage
primordial germ cell | embryonic stage, with Scer\GAL4VP16.nanos.UTR
primordial germ cell | increased number
spermatogonium
spermatogonium, with Scer\GAL4nanos.PU
testis | adult stage
testis | adult stage, with Scer\GAL4nanos.PU
wing, with Scer\GAL4Bx-MS1096
wing, with Scer\GAL4en.PU
wing, with Scer\GAL4nub-AC-62
wing, with Scer\GAL4sd.PU
wing | female limited, with Scer\GAL4Bx-MS1096
wing | female limited | cold sensitive, with Scer\GAL4Bx-MS1096
wing disc, with Scer\GAL4Bx-MS1096
wing disc, with Scer\GAL4sd.PU
wing disc | conditional
wing disc | embryonic stage | conditional (with p53-ns)
wing disc | embryonic stage | conditional (with p53TM3)
wing disc | larval stage, with Scer\GAL4hh.PU
wing disc | larval stage | conditional
wing disc | larval stage | conditional (with p53-ns)
wing disc | larval stage | conditional (with p53TM3)
wing disc | somatic clone
wing disc | third instar larval stage, with Scer\GAL4fkh.PH
wing disc | third instar larval stage, with Scer\GAL4hh.PU
wing disc | third instar larval stage | conditional
wing disc posterior compartment, with Scer\GAL4en.PU
wing disc posterior compartment, with Scer\GAL4en-e16E
wing pouch, with Scer\GAL4sd.PU
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (3)
Hsap\TP53
7 of 14
Yes
Yes
 
14  
Hsap\TP63
7 of 14
Yes
Yes
Hsap\TP73
6 of 14
No
Yes
1  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (4)
Rnor\Tp53
7 of 14
Yes
Yes
Rnor\Tp63
7 of 14
Yes
Yes
Rnor\Tp73
6 of 14
No
Yes
Rnor\LOC498414
1 of 14
No
Yes
Mus musculus (laboratory mouse) (3)
Mmus\Trp53
7 of 14
Yes
Yes
Mmus\Trp63
7 of 14
Yes
Yes
Mmus\Trp73
6 of 14
No
Yes
Xenopus tropicalis (Western clawed frog) (7)
Xtro\rad51
5 of 13
Yes
No
Xtro\tp53
5 of 13
Yes
Yes
Xtro\tp63
4 of 13
No
Yes
Xtro\tp73
3 of 13
No
Yes
Xtro\phyh
1 of 13
No
No
Xtro\stmnd1
1 of 13
No
Yes
Xtro\taf1
1 of 13
No
No
Danio rerio (Zebrafish) (3)
Drer\tp53
7 of 14
Yes
Yes
Drer\tp63
6 of 14
No
Yes
Drer\tp73
6 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (0)
Anopheles gambiae (African malaria mosquito) (2)
Agam\AgaP_AGAP002352
5 of 12
Yes
Yes
Agam\AgaP_AGAP004319
5 of 12
Yes
Yes
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:p53. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 11 )
Allele
Disease
Evidence
References
p53259H.GUS
model of  cancer
CEA
(Sidorov and Belitskii, 2002)
p535A-1-4
model of  testicular cancer
CEA
(Napoletano et al., 2017)
model of  cancer
CEA
(de la Cova et al., 2014)
p53E8
model of  testicular cancer
CEA
(Napoletano et al., 2017)
p53H159N.UAS.Ex
DOES NOT model  cancer
CEA with pnutGD1512
(Gerlach et al., 2018)
p53GD4483
model of  intestinal cancer
CEA with ApcGD1333, Ras85DV12.cUa.UAS
(Quintero and Bangi, 2023)
CEA with ApcGD1333, PtenRNAi.UAS.cUa, Ras85DV12.cUa.UAS
(Quintero and Bangi, 2023)
CEA with ApcGD1333, MedGD1483, Ras85DV12.cUa.UAS
(Quintero and Bangi, 2023)
model of  cancer
CEA with MycUAS.cZa
(Diaz et al., 2024)
p53GD11134
model of  testicular cancer
CEA
(Napoletano et al., 2017)
p53TM3
model of  cancer
CEA with p53-ns, Hsap\TP53R175H
(D'Brot et al., 2017)
CEA with p53-ns, Hsap\TP53G245S
(D'Brot et al., 2017)
CEA with p53-ns, Hsap\TP53R248Q
(D'Brot et al., 2017)
CEA with p53-ns, Hsap\TP53R273C
(D'Brot et al., 2017)
CEA with p53-ns, Hsap\TP53R273H
(D'Brot et al., 2017)
p53-ns
model of  cancer
CEA with p53TM3, Hsap\TP53R175H
(D'Brot et al., 2017)
CEA with p53TM3, Hsap\TP53G245S
(D'Brot et al., 2017)
CEA with p53TM3, Hsap\TP53R248Q
(D'Brot et al., 2017)
CEA with p53TM3, Hsap\TP53R273C
(D'Brot et al., 2017)
CEA with p53TM3, Hsap\TP53R273H
(D'Brot et al., 2017)
p53sgRNA.UAS
model of  colorectal cancer
CEA with Ras85DV12.cUa.UAS
(Zipper et al., 2022)
p53RNAi.UAS.RasG12D
model of  pancreatic ductal adenocarcinoma
CEA with CycEUAS.Tag:HA.Medsh, MedRNAi.UAS.CycE-HA, Ras85DG12D.UAS.p53sh
(Sekiya et al., 2023)
CEA with CycEUAS.Tag:HA.Medsh, MedRNAi.UAS.CycE-HA, Ras85DG12D.UAS.cSa
(Sekiya et al., 2023)
model of  cancer
CEA with MycUAS.cZa
(Diaz et al., 2024)
p53RNAi.UAS.cUa
model of  colorectal cancer
CEA with Ras85DV12.cUa.UAS, PtenGD13500, ApcRNAi.UAS.cUa, MedRNAi.UAS.cUa
(Bangi et al., 2016)
CEA with Ras85DV12.cUa.UAS, PtenGD13500, ApcRNAi.UAS.cUa
(Bangi et al., 2016)
CEA with Ras85DV12.cUa.UAS, ApcRNAi.UAS.cUa, MedRNAi.UAS.cUa
(Bangi et al., 2016)
Potential Models Based on Orthology ( 15 )
Modifiers Based on Experimental Evidence ( 15 )
Allele
Disease
Interaction
References
p5311-1B-1
ameliorates  Alexander disease
modeled by Hsap\GFAPR79H.UAS
(Wang et al., 2015)
exacerbates  tauopathy
modeled by Hsap\MAPTR406W.UAS
(Merlo et al., 2014)
ameliorates  brain ischemia
modeled by Mmus\Gria1Lc.UAS
(Lei et al., 2017)
p53259H.GUS
exacerbates  Alzheimer's disease 1
modeled by Hsap\APPArctic.Aβ42.UAS.Tag:SS(rPENK)
(Iijima et al., 2010)
p535A-1-4
ameliorates  Huntington's disease
modeled by Hsap\HTTGMR.Q120
(Bae et al., 2005)
ameliorates  cytochrome-c oxidase deficiency disease
modeled by ScoxGD898
(Martínez-Morentin et al., 2015)
exacerbates  tauopathy
modeled by Hsap\MAPTR406W.UAS
(Merlo et al., 2014)
p53Ct.GUS
exacerbates  Alzheimer's disease 1
modeled by Hsap\APPArctic.Aβ42.UAS.Tag:SS(rPENK)
(Iijima et al., 2010)
p53GMR.Ex
ameliorates  viral infectious disease
modeled by EBV\BRLF1GMR.PA
(Adamson and Lajeunesse, 2012)
exacerbates  viral infectious disease
modeled by EBV\BZLF1GMR.PA
(Adamson and Lajeunesse, 2012)
ameliorates  infectious mononucleosis
modeled by EBV\BRLF1GMR.PA
(Adamson and Lajeunesse, 2012)
exacerbates  infectious mononucleosis
modeled by EBV\BZLF1GMR.PA
(Adamson and Lajeunesse, 2012)
ameliorates  Epstein-Barr virus hepatitis
modeled by EBV\BRLF1GMR.PA
(Adamson and Lajeunesse, 2012)
exacerbates  Epstein-Barr virus hepatitis
modeled by EBV\BZLF1GMR.PA
(Adamson and Lajeunesse, 2012)
p53R155H.UAS.Ex
ameliorates  ataxia telangiectasia
modeled by tefuΔ356
(Song et al., 2004)
ameliorates  cancer
modeled by Ptip3804, Ras85DV12.cUa.UAS
(Dong et al., 2021)
p53GL01032
ameliorates  frontotemporal dementia and/or amyotrophic lateral sclerosis 1
modeled by Zzzz\GGGGCC30.UAS.EGFP
(Maor-Nof et al., 2021)
p53GD11134
model of  testicular cancer
is NOT exacerbated by HtrA2DF1
(Napoletano et al., 2017)
p53KK113065
ameliorates  cancer
modeled by Ptip3804, Ras85DV12.cUa.UAS
(Dong et al., 2021)
p53JF02513
ameliorates  Alexander disease
modeled by Hsap\GFAPR79H.UAS
(Wang et al., 2015)
p53GL01220
ameliorates  frontotemporal dementia and/or amyotrophic lateral sclerosis 1
modeled by Zzzz\GGGGCC30.UAS.EGFP
(Maor-Nof et al., 2021)
exacerbates  amyotrophic lateral sclerosis type 1
modeled by Hsap\SOD1A4V.UAS
(Lu et al., 2019)
exacerbates  frontotemporal dementia and/or amyotrophic lateral sclerosis 1
modeled by Zzzz\poly-PRPO-100.UAS
(Lu et al., 2019)
p53UAS.cUa
exacerbates  cytochrome-c oxidase deficiency disease
modeled by ScoxGD898
(Martínez-Morentin et al., 2015)
exacerbates  brain ischemia
modeled by Mmus\Gria1Lc.UAS
(Lei et al., 2017)
exacerbates  cancer
modeled by Ras85DV12.cUa.UAS
(Dong et al., 2021)
p53HMS02286
ameliorates  frontotemporal dementia and/or amyotrophic lateral sclerosis 1
modeled by Zzzz\GGGGCC30.UAS.EGFP
(Maor-Nof et al., 2021)
p53DN.UAS.cUa
ameliorates  cytochrome-c oxidase deficiency disease
modeled by ScoxGD898
(Martínez-Morentin et al., 2015)
ameliorates  brain cancer
modeled by dpnUAS.cUa
(Morrissy et al., 2016)
p53RNAi.UAS.cUa
ameliorates  Alzheimer's disease 1
modeled by Hsap\APPT12.Aβ42.UAS.Tag:SS(nec)
(Taylor and Tuxworth, 2019)
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
TP53; tumor protein p53
7 of 14
191170
 
TP63; tumor protein p63
7 of 14
603273
TP73; tumor protein p73
6 of 14
601990
     
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Dmel gene
    Ortholog showing functional complementation
    Supporting References
    p53
    Hsap\TP53
    (D'Brot et al., 2017)
    Interactions
    Summary of Physical Interactions
    Interaction Browsers
    View in FlyBase Interactions Browser   View in MIST tool (external link)
    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    p53
    anti tag coimmunoprecipitation, western blot, coimmunoprecipitation, anti tag western blot, pull down, autoradiography
    (Park et al., 2019, Zhang et al., 2015, Lunardi et al., 2010)
    p53 - AGO2
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - Acat1
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - Ada2b
    anti tag coimmunoprecipitation, anti tag western blot, pull down, western blot
    (Pankotai et al., 2013, Kusch et al., 2003)
    p53 - Ahcy
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - Bap60
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - Brd8
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - CG10333
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - CG1074
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - CG11035
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - CG1137
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - CG12861
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - CG13436
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - CG15269
    two hybrid array
    (Shokri et al., 2019)
    p53 - CG1602
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - CG1647
    two hybrid array
    (Shokri et al., 2019)
    p53 - CG1958
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - CG30059
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - CG32985
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - CG3610
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - CG4854
    two hybrid array, anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
    (Shokri et al., 2019, Rhee et al., 2014)
    p53 - CG6325
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - CG6333
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - CG6686
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - CG7139
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - CG7379
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - CG7387
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - CG7634
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - CG8236
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - CG8728
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - CG8851
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - Cep89
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - Coprox
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - Corp
    anti tag coimmunoprecipitation, anti tag western blot, pull down, autoradiography, western blot
    (Chakraborty et al., 2015)
    p53 - Cp110
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - CycG
    two hybrid, anti tag coimmunoprecipitation, western blot
    (Bayer et al., 2017)
    p53 - Cyp6a22
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - Cyp6d5
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - Cyt-c1
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - Daxx
    pull down, autoradiography, two hybrid
    (Lunardi et al., 2010, Bodai et al., 2007)
    p53 - Dlip3
    anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
    (Rhee et al., 2014)
    p53 - Dll
    two hybrid array
    (Shokri et al., 2019)
    p53 - Dph1
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - Fdh
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - Gas8
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - Gcn5
    anti bait coimmunoprecipitation, western blot, pull down
    (Kusch et al., 2003)
    p53 - Hsf
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - Hsp23
    anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
    (Rhee et al., 2014)
    p53 - Hsp26
    anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
    (Lei et al., 2017, Rhee et al., 2014)
    p53 - Hsp27
    anti bait coimmunoprecipitation, western blot
    (Lei et al., 2017)
    p53 - INPP5E
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - Ice2
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - Idi
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - Imp
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - Mmp2
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - ND-51L2
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - Nna1
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - Non1
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - Nprl3
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - PPO2
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - RPA1
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - RtcB
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - SA1
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - Sas-6
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - Sirt1
    anti tag coimmunoprecipitation, western blot
    (Bauer et al., 2009)
    p53 - Sox102F
    two hybrid array
    (Shokri et al., 2019)
    p53 - Su(var)2-10
    two hybrid, pull down, autoradiography
    (Pardi et al., 2011)
    p53 - Svil
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - TTLL5
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - Taf11
    anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
    (Rhee et al., 2014)
    p53 - Taf3
    two hybrid, pull down, autoradiography
    (Bereczki et al., 2008)
    p53 - Tfb1
    anti bait coimmunoprecipitation, western blot
    (Villicaña et al., 2013)
    p53 - Timmdc1
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - Tm1
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - Tom40
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - Topors
    pull down, autoradiography
    (Secombe and Parkhurst, 2004)
    p53 - TwdlW
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - Uba2
    two hybrid, pull down, autoradiography
    (Pardi et al., 2011)
    p53 - Ubc6
    pull down, western blot, anti tag coimmunoprecipitation, anti tag western blot, coimmunoprecipitation
    (Chen et al., 2011)
    p53 - Ubx
    bimolecular fluorescence complementation, fluorescence microscopy
    (Bischof et al., 2018)
    p53 - Usp7
    enzymatic study, western blot
    (van der Knaap et al., 2005)
    p53 - Utx
    anti bait coimmunoprecipitation, western blot
    (Zhang et al., 2013)
    p53 - Vha36-2
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - abd-A
    bimolecular fluorescence complementation, fluorescence microscopy
    (Bischof et al., 2018)
    p53 - al
    anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
    (Rhee et al., 2014)
    p53 - ap
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - asf1
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - asp
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - aub
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - boly
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - bowl
    two hybrid array
    (Shokri et al., 2019)
    p53 - bsf
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - bsk
    anti tag coimmunoprecipitation, western blot
    (Gowda et al., 2012)
    p53 - chb
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - chinmo
    two hybrid array
    (Shokri et al., 2019)
    p53 - cort
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - croc
    two hybrid array
    (Shokri et al., 2019)
    p53 - dsx
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - dup
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - dyl
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - fdl
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - grau
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - gry
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - gus
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - hay
    anti bait coimmunoprecipitation, western blot
    (Villicaña et al., 2013)
    p53 - hmw
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - if
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - jp
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - ktub
    two hybrid array
    (Shokri et al., 2019)
    p53 - lost
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - lwr
    pull down, autoradiography, two hybrid
    (Hu et al., 2017.6.13, Pardi et al., 2011)
    p53 - mRpL16
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - mTTF
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - mrj
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - mrn
    pull down, autoradiography, anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, anti tag western blot
    (Villicaña et al., 2013)
    p53 - mtgo
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - mu2
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - mura
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - nord
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - pho
    bimolecular fluorescence complementation, fluorescence microscopy, two hybrid array
    (Shokri et al., 2019)
    p53 - raskol
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - sima
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - sip3
    enzymatic study, western blot
    (Yamasaki et al., 2007)
    p53 - spoon
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - sqh
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - ssx
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - tbrd-1
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - toy
    two hybrid array, pull down, autoradiography
    (Shokri et al., 2019, Lunardi et al., 2010)
    p53 - uno
    pull down, autoradiography
    (Lunardi et al., 2010)
    p53 - yki
    anti tag coimmunoprecipitation, anti tag western blot
    (Di Cara et al., 2015)
    RNA-RNA
    Physical Interaction
    Assay
    References
    p53 - mir-1014
    luminiscence technology
    (Barrio et al., 2014)
    p53 - mir-219
    luminiscence technology, fluorescence technology
    (Barrio et al., 2014)
    p53 - mir-279
    luminiscence technology
    (Barrio et al., 2014)
    p53 - mir-283
    luminiscence technology, fluorescence technology
    (Barrio et al., 2014)
    p53 - mir-305
    fluorescence technology, necessary binding region, luminiscence technology
    (Barrio et al., 2014)
    Summary of Genetic Interactions
    Interaction Browsers
    View in FlyBase Interactions Browser   View in MIST tool (external link)
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    p53
    suppressible
    ago
    (Ouyang et al., 2011)
    p53
    suppressible
    AIF
    (Tarayrah-Ibraheim et al., 2021)
    p53
    enhanceable
    Atg1
    (Robin et al., 2019)
    Ras85D|p53|CycE|Med
    suppressible
    aurA
    (Sekiya et al., 2023)
    Ras85D|p53|CycE|Med
    suppressible
    aurB
    (Sekiya et al., 2023)
    p53|mrn
    suppressible
    bsk
    (Villicaña et al., 2013)
    p53
    suppressible
    Corp
    (Chakraborty et al., 2015)
    p53
    enhanceable
    Corp
    (Chakraborty et al., 2015)
    p53
    suppressible
    CycE
    (Ouyang et al., 2011)
    p53
    suppressible
    dap
    (Fan et al., 2010)
    p53
    suppressible
    Dark
    (Fan et al., 2010)
    p53
    enhanceable
    Daxx
    (Bodai et al., 2007)
    p53
    suppressible
    Diap1
    (Simón et al., 2014)
    p53
    suppressible
    Dronc
    (Fan et al., 2010, Kondo et al., 2006)
    Ras85D|p53|CycE|Med
    suppressible
    Dsor1
    (Sekiya et al., 2023)
    p53
    suppressible
    Erk7
    (Hasygar and Hietakangas, 2014)
    p53
    suppressible
    fzy
    (Kuang et al., 2014)
    Ras85D|Apc|p53|Pten
    enhanceable
    gig
    (Bangi et al., 2016)
    p53
    suppressible
    hay
    (Merino et al., 2002)
    p53
    suppressible
    hid
    (Fan et al., 2010)
    p53
    suppressible
    hpo
    (Colombani et al., 2006)
    p53
    enhanceable
    Hr3
    (Kim et al., 2011)
    p53
    suppressible
    Hr4
    (Müller et al., 2005)
    p53
    suppressible
    Imp
    (Müller et al., 2005)
    Apc|p53|Ras85D
    suppressible
    InR
    (Quintero and Bangi, 2023)
    p53
    suppressible
    lok
    (Brodsky et al., 2004, Peters et al., 2002)
    p53
    enhanceable
    lok
    (Bakhrat et al., 2010, Brodsky et al., 2004, Peters et al., 2002)
    p53
    suppressible
    mei-W68
    (Chakravarti et al., 2022)
    okr|p53
    suppressible
    mei-W68
    (Lu et al., 2010)
    p53
    suppressible
    mir-278
    (Müller et al., 2005)
    p53
    enhanceable
    mir-285
    (Li et al., 2017)
    p53
    suppressible
    Mnr
    (Nagel et al., 2021)
    p53
    enhanceable
    mus201
    (Jassim et al., 2003)
    p53
    suppressible
    Myt1
    (Price et al., 2002)
    p53
    suppressible
    N
    (Simón et al., 2014)
    p53
    enhanceable
    N
    (Simón et al., 2014)
    p53
    suppressible
    ninaA
    (Mendes et al., 2009)
    p53
    enhanceable
    okr
    (Chakravarti et al., 2022)
    p53
    enhanceable
    Pi3K92E
    (Lee et al., 2003)
    Apc|p53|Ras85D
    suppressible
    Pten
    (Quintero and Bangi, 2023)
    p53
    suppressible
    Ras85D
    (Murcia et al., 2019)
    Ras85D|p53|CycE|Med
    suppressible
    Rok
    (Sekiya et al., 2023)
    p53
    suppressible
    sav
    (Colombani et al., 2006)
    Apc|p53|Ras85D|Med
    suppressible
    sc
    (Quintero and Bangi, 2023)
    Apc|p53|Ras85D|Pten
    suppressible
    sc
    (Quintero and Bangi, 2023)
    Apc|p53|Ras85D
    suppressible
    sc
    (Quintero and Bangi, 2023)
    p53
    enhanceable
    Scox
    (Martínez-Morentin et al., 2015)
    p53
    suppressible
    Set
    (Kim et al., 2012)
    Ras85D|p53|CycE|Med
    suppressible
    Src42A
    (Sekiya et al., 2023)
    p53
    suppressible
    Surf1
    (Martínez-Morentin et al., 2015)
    p53
    suppressible
    synr
    (Ikegawa et al., 2023)
    Apc|p53|Ras85D
    suppressible
    Tk
    (Quintero and Bangi, 2023)
    Apc|p53|Ras85D|Pten
    suppressible
    Tk
    (Quintero and Bangi, 2023)
    Apc|p53|Ras85D|Pten
    suppressible
    TkR99D
    (Quintero and Bangi, 2023)
    Apc|p53|Ras85D
    suppressible
    TkR99D
    (Quintero and Bangi, 2023)
    Ras85D|Apc|p53|Pten
    enhanceable
    Tsc1
    (Bangi et al., 2016)
    p53
    suppressible
    Wee1
    (Price et al., 2002)
    Ras85D|p53|CycE|Med
    suppressible
    Wee1
    (Sekiya et al., 2023)
    p53
    suppressible
    wts
    (Colombani et al., 2006)
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    ais
    suppressible
    p53
    (Martin et al., 2022)
    ath
    suppressible
    p53
    (Martin et al., 2022)
    bon
    suppressible
    p53
    (Allton et al., 2009)
    COX5A
    suppressible
    p53
    (Mandal et al., 2010, Mandal et al., 2005)
    Dcr-1
    suppressible
    p53
    (Barrio et al., 2014)
    dpp
    suppressible
    p53
    (Yang and Su, 2011)
    Dref
    suppressible
    p53
    (Trong-Tue et al., 2010)
    dup
    suppressible
    p53
    (Mehrotra et al., 2008)
    Fcp1
    suppressible
    p53
    (Schauer et al., 2009)
    Fcp1
    enhanceable
    p53
    (Schauer et al., 2009)
    Fen1
    suppressible
    p53
    (Kuang et al., 2014)
    HemK2
    suppressible
    p53
    (Xu et al., 2024)
    hid
    suppressible
    p53
    (Chakraborty et al., 2015, Wells et al., 2006)
    His1
    enhanceable
    p53
    (Bayona-Feliu et al., 2017)
    His1
    suppressible
    p53
    (Bayona-Feliu et al., 2017)
    Hr3
    suppressible
    p53
    (Kim et al., 2011)
    HUWE1
    suppressible
    p53
    (Yanku et al., 2018)
    Idh
    suppressible
    p53
    (Reitman et al., 2015)
    mir-285
    enhanceable
    p53
    (Li et al., 2017)
    mrn
    enhanceable
    p53
    (Villicaña et al., 2013)
    mus201
    enhanceable
    p53
    (Jassim et al., 2003)
    Myc
    suppressible
    p53
    (de la Cova et al., 2014)
    N
    enhanceable
    p53
    (Simón et al., 2014)
    nbs
    suppressible
    p53
    (Oikemus et al., 2006)
    Nf-YA
    enhanceable
    p53
    (Tue et al., 2011)
    Non1
    suppressible
    p53
    (Martin et al., 2022)
    numb
    suppressible
    p53
    (Ouyang et al., 2011)
    okr
    suppressible
    p53
    (Chakravarti et al., 2022)
    out
    suppressible
    p53
    (Yamada et al., 2008)
    PolA1|mei-41
    suppressible
    p53
    (LaRocque et al., 2007)
    Pten|Ras85D
    suppressible
    p53
    (Bangi et al., 2016)
    pths
    suppressible
    p53
    (Martin et al., 2022)
    Ras85D
    suppressible
    p53
    (Bangi et al., 2016)
    Ras85D
    enhanceable
    Pten|Apc|p53
    (Bangi et al., 2016)
    Ras85D
    enhanceable
    Pten|Apc|Med|p53
    (Bangi et al., 2016)
    Ras85D
    enhanceable
    Pten|p53
    (Bangi et al., 2016)
    Ras85D
    enhanceable
    p53
    (Bangi et al., 2016)
    Ras85D
    enhanceable
    Pten|Med|p53
    (Bangi et al., 2016)
    Ras85D
    suppressible
    Pten|p53
    (Bangi et al., 2016)
    Ras85D
    enhanceable
    Apc|Med|p53
    (Bangi et al., 2016)
    Ras85D
    suppressible
    Pten|Apc|p53
    (Bangi et al., 2016)
    Ras85D|Apc
    suppressible
    Pten|p53
    (Bangi et al., 2016)
    raw
    suppressible
    p53
    (Yang and Su, 2011)
    Rbf
    suppressible
    p53
    (Moon et al., 2008)
    RIOK1
    suppressible
    p53
    (Hasygar and Hietakangas, 2014)
    RIOK2
    suppressible
    p53
    (Hasygar and Hietakangas, 2014)
    rl
    suppressible
    p53
    (Murcia et al., 2019)
    Rpp30
    suppressible
    p53
    (Molla-Herman et al., 2015)
    Scox
    suppressible
    p53
    (Martínez-Morentin et al., 2015)
    Scox
    enhanceable
    p53
    (Martínez-Morentin et al., 2015)
    stwl
    suppressible
    p53
    (Brun et al., 2006)
    Tak1
    suppressible
    p53
    (Yang and Su, 2011)
    tefu
    suppressible
    p53
    (Oikemus et al., 2004, Song et al., 2004)
    tefu
    enhanceable
    p53
    (Wang et al., 2013)
    wg
    enhanceable
    p53
    (Simón et al., 2014)
    wg
    suppressible
    p53
    (Ewen-Campen and Perrimon, 2024, Wells et al., 2006)
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Class of Gene
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3R
    Recombination map
    3-77
    Cytogenetic map
    94D10-94D10
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    94D10-94D10
    Limits computationally determined from genome sequence between P{lacW}GclmL0580 and P{EP}hhEP3521
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    94D-94D
    (Brodsky, 2000.1.13, Jin, 2000.3.30, Karim, 2000.3.5, Potter, 2000.3.12)
    94D-94D
    (determined by in situ hybridisation)
    (Ollmann et al., 2000)
    Experimentally Determined Recombination Data
    Location

    3-77

    (FlyBase, 2016)

    3-79.3

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (43)
    Genomic Clones (16)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (30)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    Antibody Information
    Laboratory Generated Antibodies
     

    polyclonal

    (Chang et al., 2021, Park et al., 2019, Brodsky et al., 2004, Peters et al., 2002, Brodsky et al., 2000, Ollmann et al., 2000)

    monoclonal

    (Brodsky et al., 2004, Ollmann et al., 2000)
    Commercially Available Antibodies
     
    Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
    Cell Line Information
    Publicly Available Cell Lines
     
      Other Stable Cell Lines
       
        Other Comments

        Corp protein negatively regulates p53 protein levels. Since Corp has been previously identified as a transcriptional target of p53, Corp thus produces a negative feedback loop on p53.

        (Chakraborty et al., 2015)

        Haploinsufficient locus (not associated with strong haplolethality or haplosterility).

        (Cook et al., 2012)

        p53 interacts specifically through its C-terminal domain with enzymes of the sumolyation pathway.

        (Pardi et al., 2011)

        p53 mediates the coordination of tissue growth; when growth rate is reduced in a specific territory in the developing wing disc, both growth and proliferation rates are regulated in a coordinated and non-autonomous manner by activation of p53 in the growth-depleted territory.

        (Mesquita et al., 2010)

        Kc cells have been treated with dsRNA made from templates generated with primers directed against this gene.

        (Colombani et al., 2006)

        Kc cells have been treated with dsRNA made from templates generated with primers directed against this gene to study the how p53 RNAi affects phosphorylation of the hpo product.

        (Colombani et al., 2006)

        p53 is dispensable for lkb1-dependent apoptosis and vice versa.

        (Lee et al., 2006)

        p53 protects the retina during developmentally regulated DNA damage response.

        (Jassim et al., 2003)

        dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

        (Kiger et al., 2003)

        Mutants are defective in irradiation-dependent caspase activation and do not show irradiation induced apoptosis.

        (Lee et al., 2003)

        p53 has a role in cell death and in the adaptive response to maintain genomic stability.

        (Sogame et al., 2003)

        New annotation (CG31325) in release 3 of the genome annotation.

        (FlyBase Genome Annotators, 2002-2003)

        p53 protein binds a damage response element at the rpr locus. rpr is a direct transcriptional target of p53 following DNA damage.

        (Brodsky et al., 2000)

        p53 is required for the apoptotic response to DNA damage.

        (Ollmann et al., 2000)

        Overexpression of p53 induces apoptosis (but does not induce G1 cell cycle block). Inhibition of p53 function renders cells resistant to X-ray induced apoptosis and does not affect X-ray induced cell cycle arrest.

        (Ollmann et al., 2000)
        Relationship to Other Genes
        Source for database merge of

        Source for merge of: p53 CG10873

        (FlyBase Genome Annotators, 2004, FlyBase, 1996-)
        Additional comments

        Source for merge of p53 CG10873 was sequence comparison ( date:000401 ).

        (FlyBase Genome Annotators, 2004, FlyBase, 1996-)
        Nomenclature History
        Source for database identify of
        Nomenclature comments
        Etymology
        Synonyms and Secondary IDs (18)
        Reported As
        Symbol Synonym
        CG10873
        (Brodsky, 2000.3.25, Potter, 2000.3.12)
        CG31325
        CG33336
        (Ni et al., 2011.7.19, Ni et al., 2010.12.1, Trong-Tue et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009)
        D-p53
        (Allton et al., 2009)
        DMP53
        (Kang et al., 2023, Chen et al., 2011)
        Dm-P53
        (Gorski and Marra, 2002)
        DmP53
        (Zhou, 2019, Zhang et al., 2008, Morey et al., 2003)
        Dmp53
        (Santos-Cruz et al., 2023, Ingaramo et al., 2020, Mohammadi et al., 2020, Fallahi et al., 2016, Tan et al., 2016, Nässel et al., 2015, Periz et al., 2015, Ortega-Arellano et al., 2013, Velentzas et al., 2013, Brandt et al., 2012, Gowda et al., 2012, Antosh et al., 2011, Frankel et al., 2011, Kim et al., 2011, Pardi et al., 2011, Partridge et al., 2011, Bakhrat et al., 2010, Bauer et al., 2010, Hull and Ntwasa, 2010, Palomera-Sanchez et al., 2010, Bauer et al., 2009, Schauer et al., 2009, Bereczki et al., 2008, Joza et al., 2008, Lee et al., 2008, Bauer et al., 2007, Bauer et al., 2007, Bodai et al., 2007, Der Ou et al., 2007, Peterson et al., 2007, Yamasaki et al., 2007, Colombani et al., 2006, Kondo et al., 2006, O'Keefe et al., 2006, Rebollar et al., 2006, Bauer et al., 2005, Müller et al., 2005, Pankotai et al., 2005, Pankotai et al., 2005, Kumar and Cakouros, 2004, Secombe and Parkhurst, 2004, Song et al., 2004, Christich et al., 2003, Claveria and Torres, 2003, Jassim et al., 2003, Kusch et al., 2003, Lee et al., 2003, Morey et al., 2003, Park et al., 2003, Sogame et al., 2003, Sogame et al., 2003, Gorski and Marra, 2002, Merino et al., 2002, Peters et al., 2002, Richardson and Kumar, 2002, Taylor et al., 2001, White et al., 2001, Steller, 2000)
        Dp53
        (Chan et al., 2023, Millet-Boureima et al., 2021, Baena-Lopez et al., 2018, D'Brot et al., 2017, Simoes da Silva et al., 2017, Clemente-Ruiz et al., 2016, Zhang et al., 2015, Wylie et al., 2014, Villicaña et al., 2013, Suissa et al., 2011, Fan et al., 2010, Akdemir et al., 2007)
        P53
        (Zhao et al., 2023, Sentürk et al., 2020, Mirkovic et al., 2019, Kapahi et al., 2017, Liu et al., 2017, Padash Barmchi et al., 2016, Katewa and Kapahi, 2011)
        dmP53
        (Yanku et al., 2018)
        dmp53
        (Jin et al., 2020, Chen et al., 2013, Monk et al., 2012, Tue et al., 2011, Trong-Tue et al., 2010, Fan and Bergmann, 2007, Sutcliffe and Brehm, 2004, Brun et al., 2002, Bangs et al., 2000)
        dp53
        (Dong et al., 2021, Brown et al., 2020, Lu et al., 2019, Murcia et al., 2019, Martínez-Morentin et al., 2015, Barrio et al., 2014, Herrera et al., 2013, Pankotai et al., 2013, Kim et al., 2012, Shlevkov and Morata, 2012, Ouyang et al., 2011, Khoury and Bourdon, 2010, Mesquita et al., 2010, Mendes et al., 2009, Nicholson et al., 2009, Montero et al., 2008, Moon et al., 2008, Garcia et al., 2007, Wells and Johnston, 2007, Morris et al., 2006, Wells et al., 2006, Bourdon et al., 2005, Mills, 2005, Dai et al., 2004, Van Hoof and Goris, 2003, Li et al., 2002, Pieper et al., 2002, Jin et al., 2000)
        p53
        (Alaraby et al., 2024, Chen et al., 2024, Collins et al., 2024, Dangabar Shadrack et al., 2024, Datta and Bangi, 2024, Ewen-Campen and Perrimon, 2024, Fukuda et al., 2024, Jansen et al., 2024, Li et al., 2024, Luo et al., 2024, Raicu et al., 2024, Sadanandappa and Bosco, 2024, Stanković et al., 2024, Szlanka et al., 2024, Vasavan et al., 2024, Vedelek et al., 2024, Breznak et al., 2023, Datta et al., 2023, Deng et al., 2023, Feng et al., 2023, Ikegawa et al., 2023, Kim et al., 2023, Kiparaki and Baker, 2023, Lee et al., 2023, Muita and Baxter, 2023, Quintero and Bangi, 2023, Sekiya et al., 2023, Yamada et al., 2023, Zhang et al., 2023, Baker and Montagna, 2022, Baonza et al., 2022, Chakravarti et al., 2022, Climent-Cantó et al., 2022, Demir et al., 2022, Ecovoiu et al., 2022, Eickelberg et al., 2022, Enomoto and Igaki, 2022, Feng et al., 2022, Jiang et al., 2022, Kumar and Baker, 2022, Liu et al., 2022, Logeay et al., 2022, Martin et al., 2022, Wang et al., 2022, Weina et al., 2022, Wylie et al., 2022, Yang et al., 2022, Zipper et al., 2022, Bilder et al., 2021, Chang et al., 2021, Gong et al., 2021, Harnish et al., 2021, Hounsell and Fan, 2021, Loreto et al., 2021, Maor-Nof et al., 2021, Marques-Reis and Moreno, 2021, Martin et al., 2021, Moutaoufik and Tanguay, 2021, Nagel et al., 2021, Naz and Siddique, 2021, Osman and Pek, 2021, Pang et al., 2021, Paraskevopoulos and McGuigan, 2021, Parra-Peralbo et al., 2021, Rajasekaran et al., 2021, Smylla et al., 2021, Yamaguchi et al., 2021, Yamamura et al., 2021, Yamazoe et al., 2021, Yi et al., 2021, Baker, 2020, Bhargava et al., 2020, Bozek and Gompel, 2020, Coelho, 2020, Denton et al., 2020, Gerlach and Herranz, 2020, Gohel et al., 2020, Gutiérrez-Martínez et al., 2020, Kelleher et al., 2020, Li et al., 2020, Macedo et al., 2020, Marthiens and Basto, 2020, Miller et al., 2020, Nakajima et al., 2020, Palu et al., 2020, Parniewska and Stocker, 2020, Serafini et al., 2020, Srivastav et al., 2020, Tamamouna et al., 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        prac
        (Inohara, 1999.10.6)
        Name Synonyms
        Dmp53
        (Peterson et al., 2007)
        Drosophila p53
        (Fan et al., 2010)
        p53
        (Shen et al., 2013, Moon et al., 2008, Terashima and Bownes, 2005, Gullaud et al., 2003)
        p53-like regulator of apoptosis and cell cycle
        (Inohara, 1999.10.6)
        protein 53
        (Kim et al., 2010)
        Secondary FlyBase IDs
        • FBgn0051325
        • FBgn0053336
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        Study result (0)
        Result
        Result Type
        Title
        External Crossreferences and Linkouts ( 104 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
        EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
        FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
        FlyMine - An integrated database for Drosophila genomics
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        MARRVEL_MODEL - MARRVEL (model organism gene)
        PDB - An information portal to biological macromolecular structures
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
        KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        References (612)