Dmp53, dp53
DNA repair pathway and apoptosis transcription factor - restricts retrotransposon activity and genetically interacts with components of the piRNA pathway
Please see the JBrowse view of Dmel\p53 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.48
Gene model reviewed during 5.39
Gene model reviewed during 5.55
Low-frequency RNA-Seq exon junction(s) not annotated.
1.523 (longest cDNA)
1.381 (longest cDNA)
1.6 (northern blot)
385 (aa)
Drosophila p53 protein binds the human p53 protein binding sites in the human p21 and GACC45 genes. Overexpression of Drosophila p53 protein induces apoptosis but not G1 arrest. X-ray induced apoptosis is blocked upon expression of a mutant form of p53 protein that has dominant-negative activity. p53-related genes are present in other insects (Tribolium castaneum and Leptinotarsa decemlineata EST projects).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\p53 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
Comment: undetectable in follicle cells
JBrowse - Visual display of RNA-Seq signals
View Dmel\p53 in JBrowse3-77
3-79.3
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Haploinsufficient locus (not associated with strong haplolethality or haplosterility).
p53 interacts specifically through its C-terminal domain with enzymes of the sumolyation pathway.
Kc cells have been treated with dsRNA made from templates generated with primers directed against this gene.
p53 protects the retina during developmentally regulated DNA damage response.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Mutants are defective in irradiation-dependent caspase activation and do not show irradiation induced apoptosis.
p53 has a role in cell death and in the adaptive response to maintain genomic stability.
New annotation (CG31325) in release 3 of the genome annotation.
p53 is required for the apoptotic response to DNA damage.
Source for merge of: p53 CG10873
Source for merge of p53 CG10873 was sequence comparison ( date:000401 ).