FB2025_02 , released April 17, 2025
Gene: Dmel\p53
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General Information
Symbol
Dmel\p53
Species
D. melanogaster
Name
p53
Annotation Symbol
CG33336
Feature Type
FlyBase ID
FBgn0039044
Gene Model Status
Stock Availability
Gene Summary
p53 (p53) encodes a transcriptional factor required for adaptive responses to genotoxic stress, including cell death, compensatory proliferation and DNA repair. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
Also Known As

Dmp53, dp53

Key Links
Genomic Location
Cytogenetic map
Sequence location
Recombination map
3-77
RefSeq locus
NT_033777 REGION:23049657..23054082
Sequence
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
Gene Ontology (GO) Annotations (52 terms)
Molecular Function (12 terms)
Terms Based on Experimental Evidence (8 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
Biological Process (37 terms)
Terms Based on Experimental Evidence (35 terms)
CV Term
Evidence
References
involved_in apoptotic process
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
involved_in oogenesis
inferred from genetic interaction with FLYBASE:okr; FB:FBgn0002989
inferred from genetic interaction with FLYBASE:COX5A; FB:FBgn0019624
inferred from mutant phenotype
inferred from direct assay
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
involved_in response to UV
inferred from mutant phenotype
inferred from mutant phenotype
Terms Based on Predictions or Assertions (7 terms)
CV Term
Evidence
References
Cellular Component (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
colocalizes_with chromocenter
inferred from direct assay
colocalizes_with euchromatin
inferred from direct assay
located_in nucleus
inferred from high throughput direct assay
inferred from direct assay
inferred from mutant phenotype
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in nucleus
inferred from electronic annotation with InterPro:IPR002117, InterPro:IPR012346
Protein Family (UniProt)
-
Summaries
Gene Snapshot
p53 (p53) encodes a transcriptional factor required for adaptive responses to genotoxic stress, including cell death, compensatory proliferation and DNA repair. [Date last reviewed: 2019-03-14]
Gene Group (FlyBase)
UNCLASSIFIED DNA BINDING DOMAIN TRANSCRIPTION FACTORS -
This group comprises DNA-binding transcription factors that do not classify under other domain-based transcription factor groups in FlyBase.
Summary (Interactive Fly)

DNA repair pathway and apoptosis transcription factor - restricts retrotransposon activity and genetically interacts with components of the piRNA pathway

Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\p53 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q8IMZ4)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
PDB - An information portal to biological macromolecular structures
Comments on Gene Model

Gene model reviewed during 5.48

Gene model reviewed during 5.39

Gene model reviewed during 5.55

Low-frequency RNA-Seq exon junction(s) not annotated.

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0084359
1577
385
FBtr0084360
1870
495
FBtr0301765
2095
385
FBtr0345262
1324
334
Additional Transcript Data and Comments
Reported size (kB)

1.523 (longest cDNA)

1.381 (longest cDNA)

1.6 (northern blot)

Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
FBpp0083752
43.7
385
7.30
FBpp0083753
55.6
495
6.69
FBpp0290979
43.7
385
7.30
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

385 aa isoforms: p53-PA, p53-PC
Additional Polypeptide Data and Comments
Comments

Drosophila p53 protein binds the human p53 protein binding sites in the human p21 and GACC45 genes. Overexpression of Drosophila p53 protein induces apoptosis but not G1 arrest. X-ray induced apoptosis is blocked upon expression of a mutant form of p53 protein that has dominant-negative activity. p53-related genes are present in other insects (Tribolium castaneum and Leptinotarsa decemlineata EST projects).

External Data
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\p53 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.55

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: maternally deposited

organism | uniform

Comment: maternally deposited; NOT pole cell

organism | ubiquitous

Comment: maternal contribution

northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
RNase protection, primer extension, SI map
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
colocalizes_with chromocenter
inferred from direct assay
colocalizes_with euchromatin
inferred from direct assay
located_in nucleus
inferred from high throughput direct assay
inferred from direct assay
inferred from mutant phenotype
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\p53 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 25 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 65 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of p53
Transgenic constructs containing regulatory region of p53
Aberrations (Deficiencies and Duplications) ( 2 )
Inferred from experimentation ( 2 )
Gene partially disrupted in
Inferred from location ( 9 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (3)
7 of 14
Yes
Yes
 
14  
7 of 14
Yes
Yes
6 of 14
No
Yes
1  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (4)
7 of 14
Yes
Yes
7 of 14
Yes
Yes
6 of 14
No
Yes
1 of 14
No
Yes
Mus musculus (laboratory mouse) (3)
7 of 14
Yes
Yes
7 of 14
Yes
Yes
6 of 14
No
Yes
Xenopus tropicalis (Western clawed frog) (7)
5 of 13
Yes
No
5 of 13
Yes
Yes
4 of 13
No
Yes
3 of 13
No
Yes
1 of 13
No
No
1 of 13
No
Yes
1 of 13
No
No
Danio rerio (Zebrafish) (3)
7 of 14
Yes
Yes
6 of 14
No
Yes
6 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (0)
Anopheles gambiae (African malaria mosquito) (2)
5 of 12
Yes
Yes
5 of 12
Yes
Yes
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:p53. Refer to their site for version information.
Paralogs
Paralogs (via DIOPT v9.1)
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 11 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 15 )
Modifiers Based on Experimental Evidence ( 15 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Dmel gene
Ortholog showing functional complementation
Supporting References
Interactions
Summary of Physical Interactions
Interaction Browsers

Please see the Physical Interaction reports below for full details
protein-protein
Physical Interaction
Assay
References
RNA-RNA
Physical Interaction
Assay
References
Summary of Genetic Interactions
Interaction Browsers

Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
External Data
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Class of Gene
Genomic Location and Detailed Mapping Data
Chromosome (arm)
3R
Recombination map
3-77
Cytogenetic map
Sequence location
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
94D10-94D10
Limits computationally determined from genome sequence between P{lacW}GclmL0580 and P{EP}hhEP3521
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
94D-94D
(determined by in situ hybridisation)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (43)
Genomic Clones (16)
 

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (30)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced
BDGP DGC clones
Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)
RNAi and Array Information
Linkouts
DRSC - Results frm RNAi screens
Antibody Information
Laboratory Generated Antibodies
Commercially Available Antibodies
 
Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
Cell Line Information
Publicly Available Cell Lines
 
    Other Stable Cell Lines
     
      Other Comments

      Corp protein negatively regulates p53 protein levels. Since Corp has been previously identified as a transcriptional target of p53, Corp thus produces a negative feedback loop on p53.

      Haploinsufficient locus (not associated with strong haplolethality or haplosterility).

      p53 interacts specifically through its C-terminal domain with enzymes of the sumolyation pathway.

      p53 mediates the coordination of tissue growth; when growth rate is reduced in a specific territory in the developing wing disc, both growth and proliferation rates are regulated in a coordinated and non-autonomous manner by activation of p53 in the growth-depleted territory.

      Kc cells have been treated with dsRNA made from templates generated with primers directed against this gene.

      Kc cells have been treated with dsRNA made from templates generated with primers directed against this gene to study the how p53 RNAi affects phosphorylation of the hpo product.

      p53 is dispensable for lkb1-dependent apoptosis and vice versa.

      p53 protects the retina during developmentally regulated DNA damage response.

      dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

      Mutants are defective in irradiation-dependent caspase activation and do not show irradiation induced apoptosis.

      p53 has a role in cell death and in the adaptive response to maintain genomic stability.

      New annotation (CG31325) in release 3 of the genome annotation.

      p53 protein binds a damage response element at the rpr locus. rpr is a direct transcriptional target of p53 following DNA damage.

      p53 is required for the apoptotic response to DNA damage.

      Overexpression of p53 induces apoptosis (but does not induce G1 cell cycle block). Inhibition of p53 function renders cells resistant to X-ray induced apoptosis and does not affect X-ray induced cell cycle arrest.

      Relationship to Other Genes
      Source for database merge of

      Source for merge of: p53 CG10873

      Additional comments

      Source for merge of p53 CG10873 was sequence comparison ( date:000401 ).

      Nomenclature History
      Source for database identify of
      Nomenclature comments
      Etymology
      Synonyms and Secondary IDs (18)
      Reported As
      Symbol Synonym
      CG31325
      p53
      (Alaraby et al., 2024, Chen et al., 2024, Collins et al., 2024, Dangabar Shadrack et al., 2024, Datta and Bangi, 2024, Ewen-Campen and Perrimon, 2024, Fukuda et al., 2024, Jansen et al., 2024, Li et al., 2024, Luo et al., 2024, Raicu et al., 2024, Sadanandappa and Bosco, 2024, Stanković et al., 2024, Szlanka et al., 2024, Vasavan et al., 2024, Vedelek et al., 2024, Breznak et al., 2023, Datta et al., 2023, Deng et al., 2023, Feng et al., 2023, Ikegawa et al., 2023, Kim et al., 2023, Kiparaki and Baker, 2023, Lee et al., 2023, Muita and Baxter, 2023, Quintero and Bangi, 2023, Sekiya et al., 2023, Yamada et al., 2023, Zhang et al., 2023, Baker and Montagna, 2022, Baonza et al., 2022, Chakravarti et al., 2022, Climent-Cantó et al., 2022, Demir et al., 2022, Ecovoiu et al., 2022, Eickelberg et al., 2022, Enomoto and Igaki, 2022, Feng et al., 2022, Jiang et al., 2022, Kumar and Baker, 2022, Liu et al., 2022, Logeay et al., 2022, Martin et al., 2022, Wang et al., 2022, Weina et al., 2022, Wylie et al., 2022, Yang et al., 2022, Zipper et al., 2022, Bilder et al., 2021, Chang et al., 2021, Gong et al., 2021, Harnish et al., 2021, Hounsell and Fan, 2021, Loreto et al., 2021, Maor-Nof et al., 2021, Marques-Reis and Moreno, 2021, Martin et al., 2021, Moutaoufik and Tanguay, 2021, Nagel et al., 2021, Naz and Siddique, 2021, Osman and Pek, 2021, Pang et al., 2021, Paraskevopoulos and McGuigan, 2021, Parra-Peralbo et al., 2021, Rajasekaran et al., 2021, Smylla et al., 2021, Yamaguchi et al., 2021, Yamamura et al., 2021, Yamazoe et al., 2021, Yi et al., 2021, Baker, 2020, Bhargava et al., 2020, Bozek and Gompel, 2020, Coelho, 2020, Denton et al., 2020, Gerlach and Herranz, 2020, Gohel et al., 2020, Gutiérrez-Martínez et al., 2020, Kelleher et al., 2020, Li et al., 2020, Macedo et al., 2020, Marthiens and Basto, 2020, Miller et al., 2020, Nakajima et al., 2020, Palu et al., 2020, Parniewska and Stocker, 2020, Serafini et al., 2020, Srivastav et al., 2020, Tamamouna et al., 2020, Trcek et al., 2020, Wagle and Song, 2020, Yang et al., 2020, Zurita and Murillo-Maldonado, 2020, Alaraby et al., 2019, Baker et al., 2019, Bangi et al., 2019, Barik and Mishra, 2019, Boulan et al., 2019, Khan et al., 2019, Meltzer et al., 2019, Palu et al., 2019, Park et al., 2019, Robin et al., 2019, Sanchez et al., 2019, Shokri et al., 2019, Snigdha et al., 2019, Su et al., 2019, Taylor and Tuxworth, 2019, Wei et al., 2019, Yamamoto et al., 2019, Ahmed-de-Prado and Baonza, 2018, Akishina et al., 2018, Baillon et al., 2018, Bischof et al., 2018, Clémot et al., 2018, Contreras et al., 2018, Crossman et al., 2018, Demir and Marcos, 2018, Enomoto et al., 2018, Hughes et al., 2018, Kang et al., 2018, Lee et al., 2018, Lehmann, 2018, McCarthy et al., 2018, Moon et al., 2018, Pinal et al., 2018, Rust et al., 2018, Stuelten et al., 2018, Tasnim and Kelleher, 2018, Yuan et al., 2018, Akishina et al., 2017, Bayer et al., 2017, Bayona-Feliu et al., 2017, Di Giacomo et al., 2017, Eom et al., 2017, Hu et al., 2017.6.13, Jin et al., 2017, Lei et al., 2017, Li et al., 2017, Napoletano et al., 2017, Poulton et al., 2017, Ren et al., 2017, Tavignot et al., 2017, Transgenic RNAi Project members, 2017-, Tsuyama et al., 2017, Tue et al., 2017, Wang et al., 2017, Wu et al., 2017, Yamaguchi et al., 2017, Alaraby et al., 2016, Baker and Kale, 2016, Bangi et al., 2016, Clavería and Torres, 2016, Di Gregorio et al., 2016, Eroglu and Derry, 2016, Hirabayashi, 2016, Joruiz and Bourdon, 2016, Kuleesha et al., 2016, Levine et al., 2016, Ma et al., 2016, Miller et al., 2016, Morrissy et al., 2016, Sarov et al., 2016, Wagstaff et al., 2016, Wylie et al., 2016, Wylie et al., 2016, Yadav et al., 2016, Zhang et al., 2016, Alaraby et al., 2015, Bennett et al., 2015, Bouleau and Tricoire, 2015, Chakraborty et al., 2015, Di Cara et al., 2015, Elenbaas et al., 2015, Enomoto et al., 2015, Gene Disruption Project members, 2015-, Gogendeau et al., 2015, Grewal, 2015, Hull et al., 2015, Kale et al., 2015, Kavi et al., 2015, Kopp et al., 2015, Kovacs et al., 2015, Lashmanova et al., 2015, Lion et al., 2015, Merino et al., 2015, Molla-Herman et al., 2015, O'Keefe et al., 2015, Omelyanchuk et al., 2015, Reitman et al., 2015, Sanchez-Alvarez et al., 2015, Schertel et al., 2015, Seeds et al., 2015, Su, 2015, Sun and Chen, 2015, Tower, 2015, Wang et al., 2015, Zhai et al., 2015, Zhang et al., 2015, Alic et al., 2014, de la Cova et al., 2014, Fan et al., 2014, Hasygar and Hietakangas, 2014, Iampietro et al., 2014, Kuang et al., 2014, Merlo et al., 2014, Poulton et al., 2014, Simón et al., 2014, Tanaka et al., 2014, Titen et al., 2014, Zhang et al., 2014, Ciurciu et al., 2013, Das et al., 2013, Dichtel-Danjoy et al., 2013, Hwang et al., 2013, James et al., 2013, Li et al., 2013, Link et al., 2013, Morais da Silva et al., 2013, Morishita et al., 2013, Pomerantz and Blau, 2013, Shen et al., 2013, Terriente-Felix et al., 2013, Wang et al., 2013, Zhang and Cohen, 2013, Zhang et al., 2013, Adamson and Lajeunesse, 2012, Beaucher et al., 2012, Bhadra et al., 2012, Chakrabarti et al., 2012, Cook et al., 2012, Garcia et al., 2012, Gladstone et al., 2012, Gowda et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Kang et al., 2012, Liu et al., 2012, Ma et al., 2012, Miura, 2012, Smith et al., 2012, Spedale et al., 2012, van Bergeijk et al., 2012, Vecchio et al., 2012, Wang et al., 2012, Zhai et al., 2012, Antosh et al., 2011, Bangi et al., 2011, Edwards et al., 2011, Holland et al., 2011, Kirsanov et al., 2011, Kurzhals et al., 2011, Pardi et al., 2011, Tower, 2011, Tue et al., 2011, Yang and Su, 2011, Ahamed et al., 2010, Bergantiños et al., 2010, Gan et al., 2010, Iijima et al., 2010, Kim et al., 2010, Lee et al., 2010, Li et al., 2010, Lu et al., 2010, Lunardi et al., 2010, Mandal et al., 2010, Papaconstantinou et al., 2010, Pedersen et al., 2010, Buchon et al., 2009, Hong et al., 2009, Jiang et al., 2009, Maezawa et al., 2009, McNamee and Brodsky, 2009, Peng and Karpen, 2009, Qian and Bodmer, 2009, Ravi et al., 2009, Shen et al., 2009, Waskar et al., 2009, Bereczki et al., 2008, Fan and Bergmann, 2008, Griswold et al., 2008, Hou et al., 2008, Jaklevic et al., 2008, Liu et al., 2008, Mauri et al., 2008, McNamee and Brodsky, 2008, Mehrotra et al., 2008, Moon et al., 2008, Owusu-Ansah et al., 2008, Titen and Golic, 2008, Yamada et al., 2008, Abraham et al., 2007, Akdemir et al., 2007, Bauer et al., 2007, Bauer et al., 2007, Chandraratna et al., 2007, Grewal et al., 2007, LaRocque et al., 2007, Luo et al., 2007, Tountas and Fortini, 2007, Wichmann et al., 2007, Baehrecke, 2006, Brun et al., 2006, Colombani et al., 2006, Colombani et al., 2006, Hochwagen, 2006, Lee et al., 2006, Lin and Beal, 2006, McBride et al., 2006, Morris et al., 2006, Moskalev et al., 2006, Mukherjee et al., 2006, Oikemus et al., 2006, Park et al., 2006, Singh et al., 2006, Wichmann et al., 2006, Bae et al., 2005, Bauer et al., 2005, Jager et al., 2005, Juhasz and Sass, 2005, Mandal et al., 2005, McEwen and Peifer, 2005, Terashima and Bownes, 2005, van der Knaap et al., 2005, Brodsky et al., 2004, Bruckner et al., 2004, Gorski et al., 2004, Marhold et al., 2004, Stanyon et al., 2004, Gullaud et al., 2003, Sidorov et al., 2003, Folberg-Blum et al., 2002)
      Name Synonyms
      Secondary FlyBase IDs
      • FBgn0051325
      • FBgn0053336
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      Study result (0)
      Result
      Result Type
      Title
      External Crossreferences and Linkouts ( 104 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
      DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
      EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
      FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
      FlyMine - An integrated database for Drosophila genomics
      KEGG Genes - Molecular building blocks of life in the genomic space.
      MARRVEL_MODEL - MARRVEL (model organism gene)
      PDB - An information portal to biological macromolecular structures
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
      Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
      KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
      MIST (genetic) - An integrated Molecular Interaction Database
      MIST (protein-protein) - An integrated Molecular Interaction Database
      References (612)