FB2020_03, released Jun 16, 2020

Gene: Dmel\p53

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General Information
Symbol
Dmel\p53
Species
D. melanogaster
Name
p53
Annotation Symbol
CG33336
Feature Type
protein_coding_gene
FlyBase ID
FBgn0039044
Gene Model Status
Current
Stock Availability
41 publicly available
Gene Snapshot
p53 (p53) encodes a transcriptional factor required for adaptive responses to genotoxic stress, including cell death, compensatory proliferation and DNA repair. [Date last reviewed: 2019-03-14]
Other Summaries
Also Known As

Dmp53, dp53

Key Links
Genomic Location
Cytogenetic map
94D10-94D10
Sequence location
3R:23,049,657..23,054,082 [-]
Recombination map

3-77

RefSeq locus
NT_033777 REGION:23049657..23054082
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (52 terms)
Molecular Function (9 terms)
Terms Based on Experimental Evidence (8 terms)
CV Term
Evidence
References
promoter-specific chromatin binding
inferred from direct assay
(Zhang et al., 2013)
protein binding
inferred from physical interaction with UniProtKB:Q95SP2
(assigned by UniProt )
(Yamasaki et al., 2007)
inferred from physical interaction with FLYBASE:Daxx; FB:FBgn0031820
(Bodai et al., 2007)
RNA polymerase II transcription factor binding
inferred from physical interaction with UniProtKB:Q9V4D4
(assigned by BHF-UCL )
(Bereczki et al., 2008)
TFIIH-class transcription factor complex binding
inferred from physical interaction with FLYBASE:mrn; FB:FBgn0261109
(Villicaña et al., 2013)
transcription factor binding
inferred from physical interaction with FLYBASE:bip2; FB:FBgn0026262
(Bereczki et al., 2008)
transcription regulatory region sequence-specific DNA binding
inferred from direct assay
(Merlo et al., 2014)
ubiquitin conjugating enzyme binding
inferred from physical interaction with FLYBASE:Ubc6; FB:FBgn0004436
(Chen et al., 2011)
ubiquitin protein ligase binding
inferred from physical interaction with FLYBASE:sip3; FB:FBgn0039875
(Yamasaki et al., 2007)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
DNA-binding transcription factor activity
inferred from electronic annotation with InterPro:IPR002117, InterPro:IPR008967, InterPro:IPR012346
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Biological Process (40 terms)
Terms Based on Experimental Evidence (39 terms)
CV Term
Evidence
References
activation of cysteine-type endopeptidase activity involved in apoptotic process
inferred from mutant phenotype
(Akdemir et al., 2007)
apoptotic process
inferred from mutant phenotype
(McEwen and Peifer, 2005)
cell death
inferred from mutant phenotype
(Sogame et al., 2003)
cellular response to DNA damage stimulus
inferred from mutant phenotype
(Jassim et al., 2003)
cellular response to gamma radiation
inferred from mutant phenotype
(assigned by BHF-UCL )
(Peters et al., 2002)
inferred from mutant phenotype
(D'Brot et al., 2017, Zhang et al., 2013)
cellular response to starvation
inferred from mutant phenotype
(Hasygar and Hietakangas, 2014, Hou et al., 2008)
determination of adult lifespan
inferred from mutant phenotype
(Bauer et al., 2005)
inferred from mutant phenotype
(assigned by BHF-UCL )
(Bauer et al., 2007)
ectopic germ cell programmed cell death
inferred from mutant phenotype
(Bakhrat et al., 2010)
intrinsic apoptotic signaling pathway by p53 class mediator
inferred from mutant phenotype
(assigned by BHF-UCL )
(Peters et al., 2002)
intrinsic apoptotic signaling pathway in response to DNA damage
inferred from mutant phenotype
(Moon et al., 2008)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
inferred from mutant phenotype
(Zhang et al., 2015, Colombani et al., 2006, Lee et al., 2003, Brodsky et al., 2000)
inferred from mutant phenotype
(assigned by BHF-UCL )
(Peters et al., 2002)
inferred from genetic interaction with UniProtKB:P25153
(assigned by BHF-UCL )
(Chen et al., 2011)
negative regulation of phosphatidylinositol 3-kinase activity
inferred from mutant phenotype
(assigned by BHF-UCL )
(Bauer et al., 2007)
negative regulation of photoreceptor cell differentiation
inferred from mutant phenotype
(Fan et al., 2010)
neuroblast differentiation
inferred from mutant phenotype
(Ouyang et al., 2011)
neuroblast proliferation
inferred from mutant phenotype
(Ouyang et al., 2011)
oogenesis
inferred from genetic interaction with FLYBASE:okr; FB:FBgn0002989
(Lu et al., 2010)
positive regulation of cell cycle
inferred from genetic interaction with FLYBASE:COX5A; FB:FBgn0019624
(Mandal et al., 2005)
positive regulation of cellular response to X-ray
inferred from mutant phenotype
(Brodsky et al., 2004)
positive regulation of gene expression
inferred from mutant phenotype
(D'Brot et al., 2017)
positive regulation of growth rate
inferred from mutant phenotype
(assigned by BHF-UCL )
(Bauer et al., 2007)
positive regulation of insulin-like growth factor receptor signaling pathway
inferred from mutant phenotype
(assigned by BHF-UCL )
(Bauer et al., 2007)
positive regulation of macroautophagy
inferred from mutant phenotype
(Hou et al., 2008)
positive regulation of multicellular organism growth
inferred from mutant phenotype
(assigned by BHF-UCL )
(Bauer et al., 2007)
positive regulation of necrotic cell death
inferred from mutant phenotype
(Napoletano et al., 2017)
positive regulation of protein import into nucleus
inferred from mutant phenotype
(assigned by BHF-UCL )
(Bauer et al., 2007)
positive regulation of transcription by RNA polymerase II
inferred from mutant phenotype
(assigned by BHF-UCL )
(Bauer et al., 2007, Peters et al., 2002)
positive regulation of transcription, DNA-templated
inferred from direct assay
(Brodsky et al., 2000)
inferred from mutant phenotype
(Zhang et al., 2013, Bodai et al., 2007)
reciprocal meiotic recombination
inferred from mutant phenotype
(Lu et al., 2010)
regulation of apoptosis involved in tissue homeostasis
inferred from mutant phenotype
(Zhang et al., 2015)
regulation of cell population proliferation
inferred from mutant phenotype
(Mesquita et al., 2010)
regulation of DNA repair
inferred from mutant phenotype
(Brodsky et al., 2004)
regulation of organ growth
inferred from mutant phenotype
(Mesquita et al., 2010)
regulation of transcription by RNA polymerase II
inferred from mutant phenotype
(Zhang et al., 2014)
regulation of transcription from RNA polymerase II promoter in response to DNA damage
inferred from mutant phenotype
(Zhang et al., 2015, Zhang et al., 2013)
response to ionizing radiation
inferred from mutant phenotype
(Zhang et al., 2015, Link et al., 2013, Bodai et al., 2007)
response to radiation
inferred from mutant phenotype
(Sogame et al., 2003)
response to starvation
inferred from mutant phenotype
(Barrio et al., 2014)
response to UV
inferred from mutant phenotype
(Rebollar et al., 2006)
tissue regeneration
inferred from mutant phenotype
(Wells et al., 2006)
Terms Based on Predictions or Assertions (6 terms)
CV Term
Evidence
References
apoptotic process
traceable author statement
(Richardson and Kumar, 2002, De Laurenzi and Melino, 2000)
DNA damage response, signal transduction by p53 class mediator
traceable author statement
(Gorski and Marra, 2002, Richardson and Kumar, 2002)
intrinsic apoptotic signaling pathway in response to DNA damage
traceable author statement
(Gorski and Marra, 2002)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
traceable author statement
(Walworth, 2000)
regulation of transcription by RNA polymerase II
traceable author statement
(Kumar, 2000)
response to radiation
traceable author statement
(Kumar, 2000)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
colocalizes_with chromocenter
inferred from direct assay
(Zhang et al., 2015)
nucleus
inferred from mutant phenotype
(D'Brot et al., 2017)
inferred from direct assay
(Schauer et al., 2009)
inferred from high throughput direct assay
(Sarov et al., 2016)
colocalizes_with transcriptionally active chromatin
inferred from direct assay
(Schauer et al., 2009)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
OTHER DNA BINDING DOMAIN TRANSCRIPTION FACTORS -
The Other DNA binding domain transcription factors group is a collection of DNA-binding transcription factors that do not fit into any of the other major domain-based transcription factor groups.
Summary (Interactive Fly)

DNA repair pathway and apoptosis transcription factor - restricts retrotransposon activity and genetically interacts with components of the piRNA pathway

Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
3

Please see the GBrowse view of Dmel\p53 or the JBrowse view of Dmel\p53 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.48

Gene model reviewed during 5.39

Gene model reviewed during 5.55

Low-frequency RNA-Seq exon junction(s) not annotated.

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
p53-RA
FBtr0084359
NM_206545
1577
385
p53-RB
FBtr0084360
NM_206544
1870
495
p53-RC
FBtr0301765
NM_001170223
2095
385
p53-RE
FBtr0345262
NM_001260323
1324
334
Additional Transcript Data and Comments
Reported size (kB)

1.523 (longest cDNA)

(Brodsky et al., 2000)

1.381 (longest cDNA)

(Jin et al., 2000)

1.6 (northern blot)

(Ollmann et al., 2000)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
p53-PA
FBpp0083752
43.7
385
7.30
NP_996268
AAF56087
p53-PB
FBpp0083753
55.6
495
6.69
NP_996267
AAN13925
p53-PC
FBpp0290979
43.7
385
7.30
NP_001163694
ACZ94989
p53-PE
FBpp0311439
38.2
334
8.93
NP_001247252
AFH06570
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

385 aa isoforms: p53-PA, p53-PC
Additional Polypeptide Data and Comments
Reported size (kDa)

385 (aa)

(Brodsky et al., 2000, Jin et al., 2000, Ollmann et al., 2000)
Comments

Drosophila p53 protein binds the human p53 protein binding sites in the human p21 and GACC45 genes. Overexpression of Drosophila p53 protein induces apoptosis but not G1 arrest. X-ray induced apoptosis is blocked upon expression of a mutant form of p53 protein that has dominant-negative activity. p53-related genes are present in other insects (Tribolium castaneum and Leptinotarsa decemlineata EST projects).

(Jin et al., 2000)
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\p53 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 16
germline cell
(Ollmann et al., 2000)
embryonic/larval hindgut | restricted

Comment: small patch of cells

(Ollmann et al., 2000)
oogenesis stage S10 & adult stage | female
nurse cell

Comment: undetectable in follicle cells

(Jin et al., 2000, Ollmann et al., 2000)
embryonic stage 1 -- 5
organism | ubiquitous

Comment: maternal contribution

(Jin et al., 2000)
embryonic stage 6 -- 13
organism | ubiquitous
(Jin et al., 2000)
adult stage | female & oogenesis stage S10
oocyte
(Ollmann et al., 2000)
embryonic stage 1 -- 4
organism | uniform

Comment: maternally deposited; NOT pole cell

(Ollmann et al., 2000)
embryonic stage 10
mesoderm
(Ollmann et al., 2000)
foregut primordium
(Ollmann et al., 2000)
anterior midgut primordium
(Ollmann et al., 2000)
hindgut proper primordium
(Ollmann et al., 2000)
posterior midgut primordium
(Ollmann et al., 2000)
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
germline cell
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
germline cell
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
germline cell
(Fisher et al., 2012)
gonad
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 1 -- 9
primordial germ cell
(Maezawa et al., 2009)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 10
mesoderm
(Ollmann et al., 2000)
embryonic/larval midgut
(Ollmann et al., 2000)
embryonic/larval hindgut
(Ollmann et al., 2000)
embryonic/larval foregut
(Ollmann et al., 2000)
larval stage
(Ollmann et al., 2000)
adult stage & oogenesis stage S10
oocyte
(Ollmann et al., 2000)
nurse cell
(Ollmann et al., 2000)
embryonic stage 16
embryonic/larval hindgut | restricted
(Ollmann et al., 2000)
adult stage
(Ollmann et al., 2000)
embryonic stage
(Ollmann et al., 2000)
RNase protection, primer extension, SI map
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage & oogenesis stage S10
nurse cell
(Jin et al., 2000)
embryonic stage -- adult stage
(Jin et al., 2000)
embryonic stage
(Jin et al., 2000)
adult stage | female
(Jin et al., 2000)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
colocalizes_with chromocenter
inferred from direct assay
(Zhang et al., 2015)
nucleus
inferred from mutant phenotype
(D'Brot et al., 2017)
inferred from direct assay
(Schauer et al., 2009)
inferred from high throughput direct assay
(Sarov et al., 2016)
colocalizes_with transcriptionally active chromatin
inferred from direct assay
(Schauer et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\p53 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 17 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 61 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of p53
Transgenic constructs containing regulatory region of p53
Deletions and Duplications ( 2 )
Disrupted in
Df(3R)Exel6193
(Ryder, 2004.4.26)
Partially disrupted in
In(3LR)TM3a
(Miller et al., 2016)
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4Act5C.PU
lethal, with Scer\GAL4elav-C155
lethal | male limited, with Scer\GAL4Bx-MS1096
lethal | male limited | cold sensitive, with Scer\GAL4Bx-MS1096
lethal - all die before end of pupal stage
partially lethal - majority die, with Scer\GAL4Act5C.PI
partially lethal - majority die | pupal stage, with Scer\GAL4da.G32
partially lethal - majority die | third instar larval stage, with Scer\GAL4da.G32
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
fertile
semi-sterile
Other Phenotypes
Allele
cell death defective
cell death defective | conditional
chemical resistant, with Scer\GAL4ple.PF
chemical resistant | RU486 conditional, with Scer\GAL4elav.Switch.PO
chemical sensitive
chemical sensitive | adult stage
decreased cell death
decreased cell death, with Scer\GAL4en-e16E
decreased cell death, with Scer\GAL4GMR.PF
decreased cell death | embryonic stage | conditional (with p53-ns)
decreased cell death | embryonic stage | conditional (with p53TM3)
decreased cell death | heat sensitive, with Scer\GAL4hs.PU
decreased cell death | larval stage | conditional
decreased cell death | larval stage | conditional (with p53-ns)
decreased cell death | larval stage | conditional (with p53TM3)
decreased cell death | recessive
decreased cell death | spermatogenesis
decreased cell death | spermatogenesis, with Scer\GAL4nos.PU
decreased cell death | third instar larval stage | conditional
decreased cell number, with Scer\GAL4VP16.nos.UTR
decreased cell number | adult stage, with Scer\GAL4ninaE.PT
decreased cell number | pupal stage
decreased cell number | pupal stage | somatic clone, with Scer\GAL4GMR.PU
decreased cell number | third instar larval stage
decreased cell number | third instar larval stage, with Scer\GAL4GMR.PU
developmental rate defective, with Scer\GAL4Ilp2.PR
hyperplasia | larval stage, with Scer\GAL4Bx-MS1096
hyperplasia | recessive | spermatogenesis
hyperplasia | spermatogenesis
hyperplasia | spermatogenesis, with Scer\GAL4nos.PU
immune response defective | adult stage
increased cell death
increased cell death, with Scer\GAL4Bx-MS1096
increased cell death, with Scer\GAL4Bx-MS1096, p535A-1-4
increased cell death, with Scer\GAL4Bx-MS1096, p53UAS.Dp53
increased cell death, with Scer\GAL4Bx-MS1096, p53UAS.DΔNp53
increased cell death, with Scer\GAL4en-e16E
increased cell death, with Scer\GAL4fkh.PH
increased cell death, with Scer\GAL4GMR.PF
increased cell death, with Scer\GAL4GMR.PU
increased cell death, with Scer\GAL4hs.PU
increased cell death | adult stage
increased cell death | adult stage, with Scer\GAL4ninaE.PT
increased cell death | adult stage | chemical conditional
increased cell death | adult stage | heat sensitive, with Scer\GAL4hs.PU
increased cell death | conditional
increased cell death | germline clone, with Scer\GAL4GR1
increased cell death | germline clone, with Scer\GAL4VP16.nos.UTR
increased cell death | larval stage, with Scer\GAL4sd.PU
increased cell death | third instar larval stage
increased cell death | third instar larval stage, with Scer\GAL4en.PU
increased cell death | third instar larval stage, with Scer\GAL4GMR.PU
increased cell size | somatic clone
increased mortality | adult stage | conditional
increased occurrence of cell division | larval stage, with Scer\GAL4Bx-MS1096
increased occurrence of cell division | larval stage, with Scer\GAL4sd.PU
long lived, with Scer\GAL4elav-C155
long lived | female | RU486 conditional, with Scer\GAL4Act5C.Switch.PR
long lived | RU486 conditional, with Scer\GAL4elav.Switch.PO
meiotic cell cycle defective | spermatogenesis
mitotic cell cycle defective
neoplasia | larval stage, with Scer\GAL4sd.PU
neuroanatomy defective | larval stage, with Scer\GAL4wor.PA
radiation resistant
radiation sensitive
radiation sensitive | third instar larval stage
short lived
short lived | chemical conditional
size defective, with Scer\GAL4GMR.PF
size defective | adult stage
size defective | adult stage, with Scer\GAL4GMR.PF
size defective | adult stage, with Scer\GAL4GMR.PU
size defective | larval stage, with Scer\GAL4sd.PU
small body | pupal stage, with Scer\GAL4Ilp2.PR
starvation stress response defective
starvation stress response defective, with Scer\GAL4Cg.PU
starvation stress response defective, with Scer\GAL4ppl.PP
starvation stress response defective, with Scer\GAL4yolk
visible
visible, with Scer\GAL4Bx-MS1096
visible, with Scer\GAL4GMR.PF
visible, with Scer\GAL4GMR.PU
visible | adult stage
visible | adult stage, with Scer\GAL4en.PU
visible | adult stage, with Scer\GAL4GMR.PU
visible | adult stage, with Scer\GAL4sd.PU
visible | female limited, with Scer\GAL4Bx-MS1096
visible | female limited | cold sensitive, with Scer\GAL4Bx-MS1096
wild-type
Phenotype manifest in
Allele
adult | chemical conditional
adult brain | chemical conditional
adult fat body | nutrition conditional, with Scer\GAL4ppl.PP
adult heart, with Scer\GAL4tin.CΔ4
adult heart muscle, with Scer\GAL4tin.CΔ4
autolysosome, with Scer\GAL4ninaE.PT
autophagosome, with Scer\GAL4ninaE.PT
autophagosome | supernumerary, with Scer\GAL4ninaE.PT
cardiac myofibril | adult stage, with Scer\GAL4tin.CΔ4
cone cell | pupal stage
cone cell | third instar larval stage
cystic bulge
dorsal-ventral compartment boundary of the wing disc, with Scer\GAL4sd.PU
egg chamber, with Scer\GAL4GR1
eye
eye, with Scer\GAL4ey.PH
eye, with Scer\GAL4ey.PU
eye, with Scer\GAL4GMR.PF
eye, with Scer\GAL4GMR.PU
eye | conditional
eye disc
eye disc, with Scer\GAL4GMR.PF
eye disc, with Scer\GAL4GMR.PU
eye disc | conditional
eye disc | posterior | third instar larval stage
eye disc | posterior | third instar larval stage, with Scer\GAL4GMR.PU
eye disc | pupal stage
eye disc | third instar larval stage, with Scer\GAL4GMR.PU
eye photoreceptor cell, with Scer\GAL4ninaE.PT
follicle cell | heat sensitive, with Scer\GAL4hs.PU
follicle cell | oogenesis stage S8, with Scer\GAL4hs.PU
germline cell, with Scer\GAL4VP16.nos.UTR
imaginal disc, with Scer\GAL4hs.PU
imaginal disc | third instar larval stage
interommatidial bristle
interommatidial bristle, with Scer\GAL4GMR.PF
interommatidial bristle, with Scer\GAL4GMR.PU
larval neuroblast | larval stage | conditional
lipid droplet | nutrition conditional, with Scer\GAL4ppl.PP
mitochondrion | somatic clone
neuroblast
neuroblast | larval stage, with Scer\GAL4wor.PA
ommatidium
ommatidium, with Scer\GAL4GMR.PF
ommatidium, with Scer\GAL4GMR.PU
ommatidium | pupal stage
ommatidium | pupal stage | somatic clone, with Scer\GAL4GMR.PU
onion stage spermatid
oocyte | oogenesis stage S2
oocyte | oogenesis stage S2 (with p532)
oocyte | oogenesis stage S2 (with p5311-1B-1)
oocyte | oogenesis stage S2 (with p53-ns)
outer photoreceptor cell
ovary, with Scer\GAL4VP16.nos.UTR
photoreceptor cell R7 | pupal stage | somatic clone, with Scer\GAL4GMR.PU
photoreceptor cell R7 | third instar larval stage
photoreceptor cell R7 | third instar larval stage, with Scer\GAL4GMR.PU
primordial germ cell
spermatogonium
spermatogonium, with Scer\GAL4nos.PU
testis | adult stage
testis | adult stage, with Scer\GAL4nos.PU
wing, with Scer\GAL4Bx-MS1096
wing, with Scer\GAL4en.PU
wing, with Scer\GAL4sd.PU
wing | female limited, with Scer\GAL4Bx-MS1096
wing | female limited | cold sensitive, with Scer\GAL4Bx-MS1096
wing disc, with Scer\GAL4Bx-MS1096
wing disc, with Scer\GAL4sd.PU
wing disc | conditional
wing disc | embryonic stage | conditional (with p53-ns)
wing disc | embryonic stage | conditional (with p53TM3)
wing disc | larval stage | conditional
wing disc | larval stage | conditional (with p53-ns)
wing disc | larval stage | conditional (with p53TM3)
wing disc | somatic clone
wing disc | third instar larval stage, with Scer\GAL4fkh.PH
wing disc | third instar larval stage | conditional
wing disc posterior compartment, with Scer\GAL4en.PU
wing disc posterior compartment, with Scer\GAL4en-e16E
wing pouch, with Scer\GAL4sd.PU
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\TP63
8 of 15
Yes
Yes
Hsap\TP73
8 of 15
Yes
Yes
Hsap\TP53
7 of 15
No
Yes
 
14  
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Trp63
8 of 15
Yes
Yes
Mmus\Trp73
8 of 15
Yes
Yes
Mmus\Trp53
7 of 15
No
Yes
Rattus norvegicus (Norway rat) (6)
Rnor\Tp63
7 of 13
Yes
Yes
Rnor\Tp73
7 of 13
Yes
Yes
Rnor\Tp53
5 of 13
No
Yes
Rnor\LOC100910954
2 of 13
No
Yes
Rnor\LOC498414
1 of 13
No
Yes
Rnor\LOC499219
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (3)
Xtro\tp63
5 of 12
Yes
Yes
Xtro\tp73
5 of 12
Yes
Yes
Xtro\tp53
4 of 12
No
Yes
Danio rerio (Zebrafish) (3)
Drer\tp73
8 of 15
Yes
Yes
Drer\tp53
6 of 15
No
Yes
Drer\tp63
6 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (0)
No records found.
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190CS8 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila simulans
Dsim\GD18411
Drosophila sechellia
Dsec\GM23598
Drosophila erecta
Dere\GG12467
Drosophila yakuba
Dyak\GE23990
Drosophila ananassae
Dana\GF18271
Drosophila pseudoobscura pseudoobscura
Dpse\GA27050
Drosophila persimilis
Dper\GL27356
Drosophila willistoni
Dwil\GK11606
Drosophila virilis
Dvir\GJ14364
Drosophila mojavensis
Dmoj\GI10763
Drosophila grimshawi
Dgri\GH18203
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091504JC )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17013972
Glossina morsitans
Tsetse fly
Gmor\GMOY006812
Glossina morsitans
Tsetse fly
Gmor\GMOY001706
Glossina morsitans
Tsetse fly
Gmor\GMOY000048
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_03656
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL007595
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL007594
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL013292
Anopheles darlingi
American malaria mosquito
Adar\ADAC006376
Anopheles darlingi
American malaria mosquito
Adar\ADAC006371
Anopheles gambiae
Malaria mosquito
Agam\AGAP004319
Anopheles gambiae
Malaria mosquito
Agam\AGAP002352
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ002755
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ002757
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ002756
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ002758
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ002764
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0KU0 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA013185
Danaus plexippus
Monarch butterfly
Dple\DPOGS201796-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL003574
Apis florea
Little honeybee
Aflo\3945804228
Apis mellifera
Western honey bee
Amel\LOC100577122
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP19024
Bombus terrestris
Buff-tailed bumblebee
Bter\15210939
Linepithema humile
Argentine ant
Lhum\LH21233
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000287
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG006480
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG020650
Tribolium castaneum
Red flour beetle
Tcas\TC011559
Tribolium castaneum
Red flour beetle
Tcas\TC011560
Pediculus humanus
Human body louse
Phum\PHUM003140
Rhodnius prolixus
Kissing bug
Rpro\RPRC003641
Cimex lectularius
Bed bug
Clec\CLEC002498
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI002015
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI42272
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_11991
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0L0Y )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR002642
Strigamia maritima
European centipede
Smar\SMAR002643
Ixodes scapularis
Black-legged tick
Isca\ISCW012889
Stegodyphus mimosarum
African social velvet spider
Smim\KFM58159.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM58162.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM58161.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM80478.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM72309.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM66596.1
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_304717
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 7 )
Potential Models Based on Orthology ( 15 )
Modifiers Based on Experimental Evidence ( 8 )
Allele
Disease
Interaction
References
p5311-1B-1
ameliorates  Alexander disease
modeled by Hsap\GFAPR79H.UAS
(Wang et al., 2015)
exacerbates  tauopathy
modeled by Hsap\MAPTR406W.UAS
(Merlo et al., 2014)
p535A-1-4
ameliorates  Huntington's disease
modeled by Hsap\HTTGMR.Q120
(Bae et al., 2005)
ameliorates  cytochrome-c oxidase deficiency disease
modeled by ScoxGD898
(Martínez-Morentin et al., 2015)
exacerbates  tauopathy
modeled by Hsap\MAPTR406W.UAS
(Merlo et al., 2014)
p53GMR.Ex
ameliorates  viral infectious disease
modeled by EBV\BRLF1GMR.PA
(Adamson and Lajeunesse, 2012)
exacerbates  viral infectious disease
modeled by EBV\BZLF1GMR.PA
(Adamson and Lajeunesse, 2012)
ameliorates  infectious mononucleosis
modeled by EBV\BRLF1GMR.PA
(Adamson and Lajeunesse, 2012)
exacerbates  infectious mononucleosis
modeled by EBV\BZLF1GMR.PA
(Adamson and Lajeunesse, 2012)
ameliorates  Epstein-Barr virus hepatitis
modeled by EBV\BRLF1GMR.PA
(Adamson and Lajeunesse, 2012)
exacerbates  Epstein-Barr virus hepatitis
modeled by EBV\BZLF1GMR.PA
(Adamson and Lajeunesse, 2012)
p53GD11134
model of  testicular cancer
is NOT exacerbated by HtrA2DF1
(Napoletano et al., 2017)
p53JF02513
ameliorates  Alexander disease
modeled by Hsap\GFAPR79H.UAS
(Wang et al., 2015)
p53GL01220
exacerbates  amyotrophic lateral sclerosis type 1
modeled by Hsap\SOD1A4V.UAS
(Lu et al., 2019)
exacerbates  frontotemporal dementia and/or amyotrophic lateral sclerosis-1
modeled by Zzzz\poly-PRPO-100.UAS
(Lu et al., 2019)
p53UAS.cUa
exacerbates  cytochrome-c oxidase deficiency disease
modeled by ScoxGD898
(Martínez-Morentin et al., 2015)
p53DN.UAS.cUa
ameliorates  cytochrome-c oxidase deficiency disease
modeled by ScoxGD898
(Martínez-Morentin et al., 2015)
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
TP63; tumor protein p63
8 of 15
603273
TP73; tumor protein p73
8 of 15
601990
      TP53; tumor protein p53
      7 of 15
      191170
       
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Dmel gene
      Ortholog showing functional complementation
      Supporting References
      p53
      Hsap\TP53
      (D'Brot et al., 2017)
      Interactions
      Summary of Physical Interactions
      esyN Network Diagram
      Show neighbor-neighbor interactions:
      Select Layout:
      Legend:
      Protein
      RNA
      Selected Interactor(s)
      Interactions Browser
      View in Interactions Browser
      Please see the Physical Interaction reports below for full details
      protein-protein
      Physical Interaction
      Assay
      References
      p53
      pull down, autoradiography, anti tag coimmunoprecipitation, western blot, coimmunoprecipitation, anti tag western blot
      (Park et al., 2019, Zhang et al., 2015, Lunardi et al., 2010)
      p53 - 140up
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - AGO2
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - Ada2b
      pull down, western blot, anti tag coimmunoprecipitation, anti tag western blot
      (Pankotai et al., 2013, Kusch et al., 2003)
      p53 - Ahcy
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - Bap60
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - Brd8
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - CG10333
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - CG1074
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - CG10932
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - CG11035
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - CG1137
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - CG12861
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - CG13436
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - CG15269
      two hybrid array
      (Shokri et al., 2019)
      p53 - CG1602
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - CG1647
      two hybrid array
      (Shokri et al., 2019)
      p53 - CG1958
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - CG30059
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - CG32985
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - CG3610
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - CG4854
      anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based, two hybrid array
      (Shokri et al., 2019, Rhee et al., 2014)
      p53 - CG6325
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - CG6333
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - CG6686
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - CG7139
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - CG7379
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - CG7387
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - CG7634
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - CG8236
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - CG8712
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - CG8728
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - CG8851
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - Cep89
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - Coprox
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - Corp
      pull down, western blot, autoradiography, anti tag coimmunoprecipitation, anti tag western blot
      (Chakraborty et al., 2015)
      p53 - Cp110
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - CycG
      two hybrid, anti tag coimmunoprecipitation, western blot
      (Bayer et al., 2017)
      p53 - Cyp6a22
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - Cyp6d5
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - Cyt-c1
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - Daxx
      pull down, autoradiography, two hybrid
      (Lunardi et al., 2010, Bodai et al., 2007)
      p53 - Dlip3
      anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
      (Rhee et al., 2014)
      p53 - Dll
      two hybrid array
      (Shokri et al., 2019)
      p53 - Dph1
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - Fdh
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - Gas8
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - Gcn5
      anti bait coimmunoprecipitation, western blot, pull down
      (Kusch et al., 2003)
      p53 - Hsf
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - Hsp23
      anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
      (Rhee et al., 2014)
      p53 - Hsp26
      anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based, anti bait coimmunoprecipitation, western blot
      (Lei et al., 2017, Rhee et al., 2014)
      p53 - Hsp27
      anti bait coimmunoprecipitation, western blot
      (Lei et al., 2017)
      p53 - INPP5E
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - Ice2
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - Idi
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - Imp
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - Mmp2
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - ND-51L2
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - Nna1
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - Non1
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - Nprl3
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - PPO2
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - RpA-70
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - RtcB
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - SA
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - Sas-6
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - Sirt1
      anti tag coimmunoprecipitation, western blot
      (Bauer et al., 2009)
      p53 - Sox102F
      two hybrid array
      (Shokri et al., 2019)
      p53 - Su(var)2-10
      two hybrid, pull down, autoradiography
      (Pardi et al., 2011)
      p53 - Svil
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - TTLL5
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - Taf11
      anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
      (Rhee et al., 2014)
      p53 - Tfb1
      anti bait coimmunoprecipitation, western blot
      (Villicaña et al., 2013)
      p53 - Tm1
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - Tom40
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - Topors
      pull down, autoradiography
      (Secombe and Parkhurst, 2004)
      p53 - TwdlW
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - Uba2
      two hybrid, pull down, autoradiography
      (Pardi et al., 2011)
      p53 - Ubc6
      anti tag coimmunoprecipitation, anti tag western blot, coimmunoprecipitation, pull down, western blot
      (Chen et al., 2011)
      p53 - Ubx
      bimolecular fluorescence complementation, fluorescence microscopy
      (Bischof et al., 2018)
      p53 - Usp7
      enzymatic study, western blot
      (van der Knaap et al., 2005)
      p53 - Utx
      anti bait coimmunoprecipitation, western blot
      (Zhang et al., 2013)
      p53 - Vha36-2
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - abd-A
      bimolecular fluorescence complementation, fluorescence microscopy
      (Bischof et al., 2018)
      p53 - al
      anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
      (Rhee et al., 2014)
      p53 - ap
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - asf1
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - asp
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - aub
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - bip2
      pull down, autoradiography, two hybrid
      (Bereczki et al., 2008)
      p53 - boly
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - bowl
      two hybrid array
      (Shokri et al., 2019)
      p53 - bsf
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - bsk
      anti tag coimmunoprecipitation, western blot
      (Gowda et al., 2012)
      p53 - chb
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - chinmo
      two hybrid array
      (Shokri et al., 2019)
      p53 - cort
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - croc
      two hybrid array
      (Shokri et al., 2019)
      p53 - dsx
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - dup
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - dyl
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - fdl
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - grau
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - gry
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - gus
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - hay
      anti bait coimmunoprecipitation, western blot
      (Villicaña et al., 2013)
      p53 - hmw
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - if
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - jp
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - ktub
      two hybrid array
      (Shokri et al., 2019)
      p53 - lost
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - lwr
      two hybrid, pull down, autoradiography
      (Hu et al., 2017.6.13, Pardi et al., 2011)
      p53 - mRpL16
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - mTTF
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - mrj
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - mrn
      anti tag coimmunoprecipitation, anti tag western blot, pull down, autoradiography, anti bait coimmunoprecipitation, western blot
      (Villicaña et al., 2013)
      p53 - mtgo
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - mu2
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - mura
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - nord
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - pho
      two hybrid array, bimolecular fluorescence complementation, fluorescence microscopy
      (Shokri et al., 2019)
      p53 - raskol
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - sima
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - sip3
      enzymatic study, western blot
      (Yamasaki et al., 2007)
      p53 - spoon
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - sqh
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - ssx
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - tbrd-1
      pull down, autoradiography
      (Lunardi et al., 2010)
      p53 - toy
      pull down, autoradiography, two hybrid array
      (Shokri et al., 2019, Lunardi et al., 2010)
      p53 - yki
      anti tag coimmunoprecipitation, anti tag western blot
      (Di Cara et al., 2015)
      RNA-RNA
      Physical Interaction
      Assay
      References
      p53 - mir-1014
      luminiscence technology
      (Barrio et al., 2014)
      p53 - mir-219
      luminiscence technology, fluorescence technology
      (Barrio et al., 2014)
      p53 - mir-279
      luminiscence technology
      (Barrio et al., 2014)
      p53 - mir-283
      fluorescence technology, luminiscence technology
      (Barrio et al., 2014)
      p53 - mir-305
      fluorescence technology, necessary binding region, luminiscence technology
      (Barrio et al., 2014)
      Summary of Genetic Interactions
      esyN Network Diagram
      esyN Network Key:
      Suppression
      Enhancement
      View in Interactions Browser
      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      p53
      suppressible
      ago
      (Ouyang et al., 2011)
      p53
      enhanceable
      Atg1
      (Robin et al., 2019)
      mrn|p53
      suppressible
      bsk
      (Villicaña et al., 2013)
      p53
      enhanceable
      Corp
      (Chakraborty et al., 2015)
      p53
      suppressible
      Corp
      (Chakraborty et al., 2015)
      p53
      suppressible
      CycE
      (Ouyang et al., 2011)
      p53
      suppressible
      dap
      (Fan et al., 2010)
      p53
      suppressible
      Dark
      (Fan et al., 2010)
      p53
      enhanceable
      Daxx
      (Bodai et al., 2007)
      p53
      suppressible
      Diap1
      (Simón et al., 2014)
      p53
      suppressible
      Dronc
      (Fan et al., 2010, Kondo et al., 2006)
      p53
      suppressible
      Erk7
      (Hasygar and Hietakangas, 2014)
      p53
      suppressible
      fzy
      (Kuang et al., 2014)
      Pten|Ras85D|p53|Apc
      enhanceable
      gig
      (Bangi et al., 2016)
      p53
      suppressible
      hay
      (Merino et al., 2002)
      p53
      suppressible
      hid
      (Fan et al., 2010)
      p53
      suppressible
      hpo
      (Colombani et al., 2006)
      p53
      enhanceable
      Hr3
      (Kim et al., 2011)
      p53
      suppressible
      Hr4
      (Müller et al., 2005)
      p53
      suppressible
      Imp
      (Müller et al., 2005)
      p53
      enhanceable
      lok
      (Bakhrat et al., 2010, Brodsky et al., 2004, Peters et al., 2002)
      p53
      suppressible
      lok
      (Brodsky et al., 2004, Peters et al., 2002)
      okr|p53
      suppressible
      mei-W68
      (Lu et al., 2010)
      p53
      suppressible
      mir-278
      (Müller et al., 2005)
      p53
      enhanceable
      mir-285
      (Li et al., 2017)
      p53
      enhanceable
      mus201
      (Jassim et al., 2003)
      p53
      suppressible
      Myt1
      (Price et al., 2002)
      p53
      enhanceable
      N
      (Simón et al., 2014)
      p53
      suppressible
      N
      (Simón et al., 2014)
      p53
      suppressible
      ninaA
      (Mendes et al., 2009)
      p53
      enhanceable
      Pi3K92E
      (Lee et al., 2003)
      p53
      suppressible
      sav
      (Colombani et al., 2006)
      p53
      enhanceable
      Scox
      (Martínez-Morentin et al., 2015)
      p53
      suppressible
      Set
      (Kim et al., 2012)
      p53
      suppressible
      Surf1
      (Martínez-Morentin et al., 2015)
      Pten|Ras85D|p53|Apc
      enhanceable
      Tsc1
      (Bangi et al., 2016)
      p53
      suppressible
      Wee1
      (Price et al., 2002)
      p53
      suppressible
      wts
      (Colombani et al., 2006)
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Apc|Ras85D
      suppressible
      Pten|p53
      (Bangi et al., 2016)
      bon
      suppressible
      p53
      (Allton et al., 2009)
      COX5A
      suppressible
      p53
      (Mandal et al., 2010, Mandal et al., 2005)
      Dcr-1
      suppressible
      p53
      (Barrio et al., 2014)
      DNApol-α180|mei-41
      suppressible
      p53
      (LaRocque et al., 2007)
      Dref
      suppressible
      p53
      (Trong-Tue et al., 2010)
      dup
      suppressible
      p53
      (Mehrotra et al., 2008)
      Fcp1
      enhanceable
      p53
      (Schauer et al., 2009)
      Fcp1
      suppressible
      p53
      (Schauer et al., 2009)
      Fen1
      suppressible
      p53
      (Kuang et al., 2014)
      hid
      suppressible
      p53
      (Chakraborty et al., 2015, Wells et al., 2006)
      His1:CG31617
      suppressible
      p53
      (Bayona-Feliu et al., 2017)
      His1:CG31617
      enhanceable
      p53
      (Bayona-Feliu et al., 2017)
      Hr3
      suppressible
      p53
      (Kim et al., 2011)
      HUWE1
      suppressible
      p53
      (Yanku et al., 2018)
      Idh
      suppressible
      p53
      (Reitman et al., 2015)
      mir-285
      enhanceable
      p53
      (Li et al., 2017)
      mrn
      enhanceable
      p53
      (Villicaña et al., 2013)
      mus201
      enhanceable
      p53
      (Jassim et al., 2003)
      Myc
      suppressible
      p53
      (de la Cova et al., 2014)
      N
      enhanceable
      p53
      (Simón et al., 2014)
      nbs
      suppressible
      p53
      (Oikemus et al., 2006)
      Nf-YA
      enhanceable
      p53
      (Tue et al., 2011)
      numb
      suppressible
      p53
      (Ouyang et al., 2011)
      out
      suppressible
      p53
      (Yamada et al., 2008)
      Pten|Ras85D
      suppressible
      p53
      (Bangi et al., 2016)
      Ras85D
      enhanceable
      Apc|Pten|p53
      (Bangi et al., 2016)
      Ras85D
      enhanceable
      Apc|Med|Pten|p53
      (Bangi et al., 2016)
      Ras85D
      suppressible
      Pten|p53
      (Bangi et al., 2016)
      Ras85D
      enhanceable
      Apc|Med|p53
      (Bangi et al., 2016)
      Ras85D
      enhanceable
      p53
      (Bangi et al., 2016)
      Ras85D
      suppressible
      Apc|Pten|p53
      (Bangi et al., 2016)
      Ras85D
      enhanceable
      Med|Pten|p53
      (Bangi et al., 2016)
      Ras85D
      suppressible
      p53
      (Bangi et al., 2016)
      Ras85D
      enhanceable
      Pten|p53
      (Bangi et al., 2016)
      Rbf
      suppressible
      p53
      (Moon et al., 2008)
      RIOK1
      suppressible
      p53
      (Hasygar and Hietakangas, 2014)
      RIOK2
      suppressible
      p53
      (Hasygar and Hietakangas, 2014)
      Rpp30
      suppressible
      p53
      (Molla-Herman et al., 2015)
      Scox
      enhanceable
      p53
      (Martínez-Morentin et al., 2015)
      Scox
      suppressible
      p53
      (Martínez-Morentin et al., 2015)
      stwl
      suppressible
      p53
      (Brun et al., 2006)
      tefu
      enhanceable
      p53
      (Wang et al., 2013)
      tefu
      suppressible
      p53
      (Oikemus et al., 2004, Song et al., 2004)
      wg
      enhanceable
      p53
      (Simón et al., 2014)
      wg
      suppressible
      p53
      (Wells et al., 2006)
      External Data
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      MIST (genetic) - An integrated Molecular Interaction Database
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      External Data
      Linkouts
      KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      3R
      Recombination map

      3-77

      Cytogenetic map
      94D10-94D10
      Sequence location
      3R:23,049,657..23,054,082 [-]
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      94D10-94D10
      Limits computationally determined from genome sequence between P{lacW}GclmL0580 and P{EP}hhEP3521
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      94D-94D
      (determined by in situ hybridisation)
      (Ollmann et al., 2000)
      94D-94D
      (Brodsky, 2000.1.13, Jin, 2000.3.30, Karim, 2000.3.5, Potter, 2000.3.12)
      Experimentally Determined Recombination Data
      Location

      3-77

      (FlyBase, 2016)

      3-79.3

      (Comeron et al., 2012)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (41)
      Genomic Clones (16)
       

      Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

      cDNA Clones (31)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
      Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
       

      polyclonal

      (Park et al., 2019, Brodsky et al., 2004, Peters et al., 2002, Brodsky et al., 2000, Ollmann et al., 2000)

      monoclonal

      (Brodsky et al., 2004, Ollmann et al., 2000)
      Commercially Available Antibodies
       
      Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
      Other Information
      Relationship to Other Genes
      Source for database identify of
      Source for database merge of

      Source for merge of: p53 CG10873

      (FlyBase Genome Annotators, 2004, FlyBase, 1996-)
      Additional comments

      Source for merge of p53 CG10873 was sequence comparison ( date:000401 ).

      (FlyBase Genome Annotators, 2004, FlyBase, 1996-)
      Other Comments

      Corp protein negatively regulates p53 protein levels. Since Corp has been previously identified as a transcriptional target of p53, Corp thus produces a negative feedback loop on p53.

      (Chakraborty et al., 2015)

      Haploinsufficient locus (not associated with strong haplolethality or haplosterility).

      (Cook et al., 2012)

      p53 interacts specifically through its C-terminal domain with enzymes of the sumolyation pathway.

      (Pardi et al., 2011)

      p53 mediates the coordination of tissue growth; when growth rate is reduced in a specific territory in the developing wing disc, both growth and proliferation rates are regulated in a coordinated and non-autonomous manner by activation of p53 in the growth-depleted territory.

      (Mesquita et al., 2010)

      Kc cells have been treated with dsRNA made from templates generated with primers directed against this gene.

      (Colombani et al., 2006)

      Kc cells have been treated with dsRNA made from templates generated with primers directed against this gene to study the how p53 RNAi affects phosphorylation of the hpo product.

      (Colombani et al., 2006)

      p53 is dispensable for lkb1-dependent apoptosis and vice versa.

      (Lee et al., 2006)

      p53 protects the retina during developmentally regulated DNA damage response.

      (Jassim et al., 2003)

      dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

      (Kiger et al., 2003)

      Mutants are defective in irradiation-dependent caspase activation and do not show irradiation induced apoptosis.

      (Lee et al., 2003)

      p53 has a role in cell death and in the adaptive response to maintain genomic stability.

      (Sogame et al., 2003)

      New annotation (CG31325) in release 3 of the genome annotation.

      (FlyBase Genome Annotators, 2002-2003)

      p53 protein binds a damage response element at the rpr locus. rpr is a direct transcriptional target of p53 following DNA damage.

      (Brodsky et al., 2000)

      p53 is required for the apoptotic response to DNA damage.

      (Ollmann et al., 2000)

      Overexpression of p53 induces apoptosis (but does not induce G1 cell cycle block). Inhibition of p53 function renders cells resistant to X-ray induced apoptosis and does not affect X-ray induced cell cycle arrest.

      (Ollmann et al., 2000)
      Origin and Etymology
      Discoverer
      Etymology
      Identification
      External Crossreferences and Linkouts ( 83 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
      InterPro - A database of protein families, domains and functional sites
      KEGG Genes - Molecular building blocks of life in the genomic space.
      modMine - A data warehouse for the modENCODE project
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DPiM - Drosophila Protein interaction map
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
      FlyMine - An integrated database for Drosophila genomics
      Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
      MIST (genetic) - An integrated Molecular Interaction Database
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Synonyms and Secondary IDs (18)
      Reported As
      Symbol Synonym
      CG10873
      (Brodsky, 2000.3.25, Potter, 2000.3.12)
      CG31325
      CG33336
      (Ni et al., 2011.7.19, Ni et al., 2010.12.1, Trong-Tue et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009)
      D-p53
      (Allton et al., 2009)
      DMP53
      (Chen et al., 2011)
      Dm-P53
      (Gorski and Marra, 2002)
      DmP53
      (Zhang et al., 2008, Morey et al., 2003)
      Dmp53
      (Fallahi et al., 2016, Tan et al., 2016, Nässel et al., 2015, Ortega-Arellano et al., 2013, Brandt et al., 2012, Gowda et al., 2012, Antosh et al., 2011, Frankel et al., 2011, Kim et al., 2011, Pardi et al., 2011, Partridge et al., 2011, Bakhrat et al., 2010, Bauer et al., 2010, Hull and Ntwasa, 2010, Palomera-Sanchez et al., 2010, Bauer et al., 2009, Schauer et al., 2009, Bereczki et al., 2008, Joza et al., 2008, Lee et al., 2008, Bauer et al., 2007, Bauer et al., 2007, Bodai et al., 2007, Der Ou et al., 2007, Peterson et al., 2007, Yamasaki et al., 2007, Colombani et al., 2006, Kondo et al., 2006, O'Keefe et al., 2006, Rebollar et al., 2006, Bauer et al., 2005, Müller et al., 2005, Pankotai et al., 2005, Pankotai et al., 2005, Kumar and Cakouros, 2004, Secombe and Parkhurst, 2004, Song et al., 2004, Christich et al., 2003, Claveria and Torres, 2003, Jassim et al., 2003, Kusch et al., 2003, Lee et al., 2003, Morey et al., 2003, Park et al., 2003, Sogame et al., 2003, Sogame et al., 2003, Gorski and Marra, 2002, Merino et al., 2002, Peters et al., 2002, Richardson and Kumar, 2002, Taylor et al., 2001, White et al., 2001, Steller, 2000)
      Dp53
      (Baena-Lopez et al., 2018, D'Brot et al., 2017, Simoes da Silva et al., 2017, Clemente-Ruiz et al., 2016, Zhang et al., 2015, Wylie et al., 2014, Villicaña et al., 2013, Suissa et al., 2011, Fan et al., 2010, Akdemir et al., 2007)
      P53
      (Mirkovic et al., 2019, Kapahi et al., 2017, Liu et al., 2017, Padash Barmchi et al., 2016, Katewa and Kapahi, 2011)
      dmP53
      (Yanku et al., 2018)
      dmp53
      (Chen et al., 2013, Monk et al., 2012, Tue et al., 2011, Trong-Tue et al., 2010, Fan and Bergmann, 2007, Sutcliffe and Brehm, 2004, Brun et al., 2002, Bangs et al., 2000)
      dp53
      (Lu et al., 2019, Murcia et al., 2019, Martínez-Morentin et al., 2015, Barrio et al., 2014, Herrera et al., 2013, Pankotai et al., 2013, Kim et al., 2012, Shlevkov and Morata, 2012, Ouyang et al., 2011, Khoury and Bourdon, 2010, Mesquita et al., 2010, Mendes et al., 2009, Nicholson et al., 2009, Montero et al., 2008, Moon et al., 2008, Garcia et al., 2007, Wells and Johnston, 2007, Morris et al., 2006, Wells et al., 2006, Bourdon et al., 2005, Mills, 2005, Dai et al., 2004, Van Hoof and Goris, 2003, Li et al., 2002, Pieper et al., 2002, Jin et al., 2000)
      p53
      (Kelleher et al., 2020, Palu et al., 2020, Alaraby et al., 2019, Baker et al., 2019, Bangi et al., 2019, Barik and Mishra, 2019, Boulan et al., 2019, Khan et al., 2019, Meltzer et al., 2019, Palu et al., 2019, Park et al., 2019, Robin et al., 2019, Sanchez et al., 2019, Shokri et al., 2019, Snigdha et al., 2019, Su et al., 2019, Taylor and Tuxworth, 2019, Wei et al., 2019, Yamamoto et al., 2019, Ahmed-de-Prado and Baonza, 2018, Akishina et al., 2018, Bischof et al., 2018, Clémot et al., 2018, Contreras et al., 2018, Demir and Marcos, 2018, Enomoto et al., 2018, Hughes et al., 2018, Kang et al., 2018, Lee et al., 2018, Lehmann, 2018, McCarthy et al., 2018, Moon et al., 2018, Pinal et al., 2018, Rust et al., 2018, Stuelten et al., 2018, Tasnim and Kelleher, 2018, Yuan et al., 2018, Akishina et al., 2017, Bayona-Feliu et al., 2017, Di Giacomo et al., 2017, Eom et al., 2017, Hu et al., 2017.6.13, Jin et al., 2017, Lei et al., 2017, Li et al., 2017, Napoletano et al., 2017, Poulton et al., 2017, Ren et al., 2017, Tavignot et al., 2017, Transgenic RNAi Project members, 2017-, Tsuyama et al., 2017, Tue et al., 2017, Wang et al., 2017, Wu et al., 2017, Yamaguchi et al., 2017, Alaraby et al., 2016, Baker and Kale, 2016, Bangi et al., 2016, Clavería and Torres, 2016, Di Gregorio et al., 2016, Eroglu and Derry, 2016, Hirabayashi, 2016, Joruiz and Bourdon, 2016, Kuleesha et al., 2016, Levine et al., 2016, Ma et al., 2016, Miller et al., 2016, Sarov et al., 2016, Wylie et al., 2016, Wylie et al., 2016, Yadav et al., 2016, Alaraby et al., 2015, Bennett et al., 2015, Bouleau and Tricoire, 2015, Chakraborty et al., 2015, Di Cara et al., 2015, Elenbaas et al., 2015, Enomoto et al., 2015, Gene Disruption Project members, 2015-, Gogendeau et al., 2015, Grewal, 2015, Hull et al., 2015, Kale et al., 2015, Kavi et al., 2015, Kopp et al., 2015, Kovacs et al., 2015, Lashmanova et al., 2015, Lion et al., 2015, Merino et al., 2015, Molla-Herman et al., 2015, O'Keefe et al., 2015, Omelyanchuk et al., 2015, Reitman et al., 2015, Sanchez-Alvarez et al., 2015, Schertel et al., 2015, Seeds et al., 2015, Su, 2015, Sun and Chen, 2015, Tower, 2015, Wang et al., 2015, Zhai et al., 2015, Zhang et al., 2015, Alic et al., 2014, de la Cova et al., 2014, Fan et al., 2014, Hasygar and Hietakangas, 2014, Kuang et al., 2014, Merlo et al., 2014, Poulton et al., 2014, Simón et al., 2014, Tanaka et al., 2014, Titen et al., 2014, Zhang et al., 2014, Ciurciu et al., 2013, Das et al., 2013, Dichtel-Danjoy et al., 2013, Hwang et al., 2013, James et al., 2013, Link et al., 2013, Morais da Silva et al., 2013, Morishita et al., 2013, Pomerantz and Blau, 2013, Shen et al., 2013, Terriente-Felix et al., 2013, Wang et al., 2013, Zhang and Cohen, 2013, Zhang et al., 2013, Adamson and Lajeunesse, 2012, Beaucher et al., 2012, Bhadra et al., 2012, Chakrabarti et al., 2012, Cook et al., 2012, Garcia et al., 2012, Gladstone et al., 2012, Gowda et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Kang et al., 2012, Liu et al., 2012, Ma et al., 2012, Miura, 2012, Spedale et al., 2012, van Bergeijk et al., 2012, Vecchio et al., 2012, Wang et al., 2012, Zhai et al., 2012, Antosh et al., 2011, Bangi et al., 2011, Edwards et al., 2011, Holland et al., 2011, Kirsanov et al., 2011, Kurzhals et al., 2011, Pardi et al., 2011, Tower, 2011, Tue et al., 2011, Yang and Su, 2011, Ahamed et al., 2010, Bergantiños et al., 2010, Gan et al., 2010, Iijima et al., 2010, Kim et al., 2010, Lee et al., 2010, Li et al., 2010, Lu et al., 2010, Lunardi et al., 2010, Mandal et al., 2010, Papaconstantinou et al., 2010, Pedersen et al., 2010, Buchon et al., 2009, Hong et al., 2009, Jiang et al., 2009, Maezawa et al., 2009, McNamee and Brodsky, 2009, Peng and Karpen, 2009, Qian and Bodmer, 2009, Ravi et al., 2009, Shen et al., 2009, Waskar et al., 2009, Bereczki et al., 2008, Fan and Bergmann, 2008, Griswold et al., 2008, Hou et al., 2008, Jaklevic et al., 2008, Liu et al., 2008, Mauri et al., 2008, McNamee and Brodsky, 2008, Mehrotra et al., 2008, Moon et al., 2008, Owusu-Ansah et al., 2008, Titen and Golic, 2008, Yamada et al., 2008, Abraham et al., 2007, Akdemir et al., 2007, Bauer et al., 2007, Bauer et al., 2007, Chandraratna et al., 2007, Grewal et al., 2007, LaRocque et al., 2007, Luo et al., 2007, Tountas and Fortini, 2007, Wichmann et al., 2007, Baehrecke, 2006, Brun et al., 2006, Colombani et al., 2006, Colombani et al., 2006, Hochwagen, 2006, Lee et al., 2006, Lin and Beal, 2006, McBride et al., 2006, Morris et al., 2006, Moskalev et al., 2006, Mukherjee et al., 2006, Oikemus et al., 2006, Park et al., 2006, Singh et al., 2006, Wichmann et al., 2006, Bae et al., 2005, Bauer et al., 2005, Jager et al., 2005, Juhasz and Sass, 2005, Mandal et al., 2005, McEwen and Peifer, 2005, Terashima and Bownes, 2005, van der Knaap et al., 2005, Brodsky et al., 2004, Bruckner et al., 2004, Gorski et al., 2004, Marhold et al., 2004, Stanyon et al., 2004, Gullaud et al., 2003, Sidorov et al., 2003, Folberg-Blum et al., 2002)
      prac
      (Inohara, 1999.10.6)
      Name Synonyms
      Dmp53
      (Peterson et al., 2007)
      Drosophila p53
      (Fan et al., 2010)
      p53
      (Shen et al., 2013, Moon et al., 2008, Terashima and Bownes, 2005, Gullaud et al., 2003)
      p53-like regulator of apoptosis and cell cycle
      (Inohara, 1999.10.6)
      protein 53
      (Kim et al., 2010)
      Secondary FlyBase IDs
      • FBgn0051325
      • FBgn0053336
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      References (463)