Gene model reviewed during 5.48
Gene model reviewed during 5.39
Gene model reviewed during 5.55
Low-frequency RNA-Seq exon junction(s) not annotated.
Drosophila p53 protein binds the human p53 protein binding sites in the human p21 and GACC45 genes. Overexpression of Drosophila p53 protein induces apoptosis but not G1 arrest. X-ray induced apoptosis is blocked upon expression of a mutant form of p53 protein that has dominant-negative activity. p53-related genes are present in other insects (Tribolium castaneum and Leptinotarsa decemlineata EST projects).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\p53 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\p53 in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Haploinsufficient locus (not associated with strong haplolethality or haplosterility).
p53 interacts specifically through its C-terminal domain with enzymes of the sumolyation pathway.
p53 mediates the coordination of tissue growth; when growth rate is reduced in a specific territory in the developing wing disc, both growth and proliferation rates are regulated in a coordinated and non-autonomous manner by activation of p53 in the growth-depleted territory.
Kc cells have been treated with dsRNA made from templates generated with primers directed against this gene.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Mutants are defective in irradiation-dependent caspase activation and do not show irradiation induced apoptosis.
p53 has a role in cell death and in the adaptive response to maintain genomic stability.
New annotation (CG31325) in release 3 of the genome annotation.