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Gene Dmel\CG6726

General Information
Symbol	Dmel\CG6726	Species	D. melanogaster
Name		Annotation symbol	CG6726
Feature type	protein_coding_gene	FlyBase ID	FBgn0039049
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	94D13-94D13	Sequence location	3R:18,917,446..18,919,181 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG6726 (FBgn0039049). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: aminoacylase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: cellular amino acid metabolic process. 5 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: N-acyl-L-amino-acid amidohydrolase; Peptidase M20; Peptidase M20, dimerisation domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed during late larval stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult hindgut, larval/adult Malpighian tubules, larval fat body. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval/adult midgut, larval hindgut, larval salivary gland, larval trachea, adult ovary, adult male accessory gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1623849_s_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of CG6726. Gene sequence location is 3R:18917446..18919181.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 94D13-94D13   Limits computationally determined from genome sequence between P{lacW}GclmL0580 and P{EP}hhEP3521
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG6726 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.48
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG6726-RA FBtr0084349  NM_142863   1473   401 CG6726-RB FBtr0084348  NM_170048   1420   401
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG6726-PA   FBpp0083742   45.0   401   5.33     NP_651120   AAF56094 CG6726-PB   FBpp0083741   45.0   401   5.33     NP_732822   AAN13926
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Peptidase M20 (IPR002933) N-acyl-L-amino-acid amidohydrolase (IPR010159) Peptidase M20, dimerisation domain (IPR011650)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141167   AA141168   AA202274   AE014297 AAF56094   AE014297 AAN13926   AI297254   AY119627 AAM50281   BI171719   BI362040   BI481691   CK657152   CO183493   CO192147   EC052228   EC052232   EC053254   EC056530   EV578029   GH747927   GH752167   GH752249   GH752907   GH754698   GH755577   GH756448   GH758065   GH758573   GH773338   GH777996   GH778519   GH778682   GH780281   GH783241   GH786834   GH786858   GH795614   GH797149   GH797549   GH797757   GH800796   GH802014   GH802156   GH802748   GH803977   GH806819   GH808174   GH814668   GH818603   GH818670   GH818672   GH818940   GH820972   GH821198   GH822451   GH823666   GH825823   GH830087   GH832612   GH836168   GH836423   GH837010   GH837039   GH838681   GH838745   GH840459   GH841246   GH844642   GH847184   GH847192   GH847379   GH847614   GH848262   GH849544   GH849742   GH851913   GH853815   GH854968   GH856711   GH860537   GH863839   GH864028   GH866419   GH871599   GH872845   GH873532   GH875521   GH875781   GH876105   GH878576   GH880722   GH880899   GH887797   GH888920   GH888925   GH891599   GH895612   GH900400   GH902275   GH908550   GH910281   GH913161   GH915705   GH921585   GH921645   GH926204   GH932191   GH932354   GH933804   GH936085   GH937885   GH937946   GH939455   GH940655
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VCR2 Q7JUX5
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 13 -- 16   crystal cell   (Fisher et al., 2012) embryonic Malpighian tubule   (Fisher et al., 2012) embryonic/larval garland cell   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult hindgut, larval/adult Malpighian tubules, larval fat body. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval/adult midgut, larval hindgut, larval salivary gland, larval trachea, adult ovary, adult male accessory gland, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    109.825 Larval Midgut    467.3 Larval Hindgut    317.2 Larval Malpighian Tubules    6396.6 Larval Fat Body    586.2 Larval Salivary Gland    246.8 Larval Trachea    103.525 Larval Carcass    228.25 Adult Head    55.4 Adult Eye    55.725 Adult Brain    22.5 Adult Thoracic-Abdominal Ganglion    37.2 Adult Crop    53.8 Adult Midgut    105.5 Adult Hindgut    669.2 Adult Malpighian Tubules    8244.2 Adult Fat Body    84.5 Adult Salivary Gland    87.5 Adult Heart    67.95 Adult VirginFemale Spermatheca    72.3 Adult InseminatedFemale Spermatheca    60.8 Adult Ovary    111.3 Adult Testis    9.5 Adult Male Accessory Gland    123.5 Adult Carcass    61.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    109.825 Larval Midgut    467.3 Larval Hindgut    317.2 Larval Malpighian Tubules  (6396.6) Larval Fat Body  (586.2) Larval Salivary Gland    246.8 Larval Trachea    103.525 Larval Carcass    228.25 Adult Head    55.4 Adult Eye    55.725 Adult Brain    22.5 Adult Thoracic-Abdominal Ganglion    37.2 Adult Crop    53.8 Adult Midgut    105.5 Adult Hindgut  (669.2) Adult Malpighian Tubules  (8244.2) Adult Fat Body    84.5 Adult Salivary Gland    87.5 Adult Heart    67.95 Adult VirginFemale Spermatheca    72.3 Adult InseminatedFemale Spermatheca    60.8 Adult Ovary    111.3 Adult Testis    9.5 Adult Male Accessory Gland    123.5 Adult Carcass    61.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    109.825 Larval Midgut    467.3 Larval Hindgut    317.2 Larval Malpighian Tubules  (6396.6) Larval Fat Body    586.2 Larval Salivary Gland    246.8 Larval Trachea    103.525 Larval Carcass    228.25 Adult Head    55.4 Adult Eye    55.725 Adult Brain    22.5 Adult Thoracic-Abdominal Ganglion    37.2 Adult Crop    53.8 Adult Midgut    105.5 Adult Hindgut    669.2 Adult Malpighian Tubules  (8244.2) Adult Fat Body    84.5 Adult Salivary Gland    87.5 Adult Heart    67.95 Adult VirginFemale Spermatheca    72.3 Adult InseminatedFemale Spermatheca    60.8 Adult Ovary    111.3 Adult Testis    9.5 Adult Male Accessory Gland    123.5 Adult Carcass    61.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    109.825 Larval Midgut    467.3 Larval Hindgut    317.2 Larval Malpighian Tubules    6396.6 Larval Fat Body    586.2 Larval Salivary Gland    246.8 Larval Trachea    103.525 Larval Carcass    228.25 Adult Head    55.4 Adult Eye    55.725 Adult Brain    22.5 Adult Thoracic-Abdominal Ganglion    37.2 Adult Crop    53.8 Adult Midgut    105.5 Adult Hindgut    669.2 Adult Malpighian Tubules    8244.2 Adult Fat Body    84.5 Adult Salivary Gland    87.5 Adult Heart    67.95 Adult VirginFemale Spermatheca    72.3 Adult InseminatedFemale Spermatheca    60.8 Adult Ovary    111.3 Adult Testis    9.5 Adult Male Accessory Gland    123.5 Adult Carcass    61.8 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    109.825 Larval Midgut    467.3 Larval Hindgut    317.2 Larval Malpighian Tubules    6396.6 Larval Fat Body    586.2 Larval Salivary Gland    246.8 Larval Trachea    103.525 Larval Carcass    228.25 Adult Head    55.4 Adult Eye    55.725 Adult Brain    22.5 Adult Thoracic-Abdominal Ganglion    37.2 Adult Crop    53.8 Adult Midgut    105.5 Adult Hindgut    669.2 Adult Malpighian Tubules    8244.2 Adult Fat Body    84.5 Adult Salivary Gland    87.5 Adult Heart    67.95 Adult VirginFemale Spermatheca    72.3 Adult InseminatedFemale Spermatheca    60.8 Adult Ovary    111.3 Adult Testis    9.5 Adult Male Accessory Gland    123.5 Adult Carcass    61.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    109.825 Larval Midgut    467.3 Larval Hindgut    317.2 Larval Malpighian Tubules  (6396.6) Larval Fat Body  586.2 Larval Salivary Gland    246.8 Larval Trachea    103.525 Larval Carcass    228.25 Adult Head    55.4 Adult Eye    55.725 Adult Brain    22.5 Adult Thoracic-Abdominal Ganglion    37.2 Adult Crop    53.8 Adult Midgut    105.5 Adult Hindgut  669.2 Adult Malpighian Tubules  (8244.2) Adult Fat Body    84.5 Adult Salivary Gland    87.5 Adult Heart    67.95 Adult VirginFemale Spermatheca    72.3 Adult InseminatedFemale Spermatheca    60.8 Adult Ovary    111.3 Adult Testis    9.5 Adult Male Accessory Gland    123.5 Adult Carcass    61.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    109.825 Larval Midgut    467.3 Larval Hindgut    317.2 Larval Malpighian Tubules  (6396.6) Larval Fat Body    586.2 Larval Salivary Gland    246.8 Larval Trachea    103.525 Larval Carcass    228.25 Adult Head    55.4 Adult Eye    55.725 Adult Brain    22.5 Adult Thoracic-Abdominal Ganglion    37.2 Adult Crop    53.8 Adult Midgut    105.5 Adult Hindgut    669.2 Adult Malpighian Tubules  (8244.2) Adult Fat Body    84.5 Adult Salivary Gland    87.5 Adult Heart    67.95 Adult VirginFemale Spermatheca    72.3 Adult InseminatedFemale Spermatheca    60.8 Adult Ovary    111.3 Adult Testis    9.5 Adult Male Accessory Gland    123.5 Adult Carcass    61.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    109.825 Larval Midgut    467.3 Larval Hindgut    317.2 Larval Malpighian Tubules    6396.6 Larval Fat Body    586.2 Larval Salivary Gland    246.8 Larval Trachea    103.525 Larval Carcass    228.25 Adult Head    55.4 Adult Eye    55.725 Adult Brain    22.5 Adult Thoracic-Abdominal Ganglion    37.2 Adult Crop    53.8 Adult Midgut    105.5 Adult Hindgut    669.2 Adult Malpighian Tubules    8244.2 Adult Fat Body    84.5 Adult Salivary Gland    87.5 Adult Heart    67.95 Adult VirginFemale Spermatheca    72.3 Adult InseminatedFemale Spermatheca    60.8 Adult Ovary    111.3 Adult Testis    9.5 Adult Male Accessory Gland    123.5 Adult Carcass    61.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    55.4   NA  Eye    55.725   NA  Brain    22.5   109.825  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    37.2   NA  Crop    53.8   467.3  Midgut    105.5   317.2  Hindgut    669.2   6396.6  Malpighian Tubules    8244.2   586.2  Fat Body    84.5   246.8  Salivary Gland    87.5   NA  Heart    67.95   103.525  Trachea    NA   NA  VirginFemale Spermatheca    72.3   NA  InseminatedFemale Spermatheca    60.8   NA  Ovary    111.3   NA  Testis    9.5   NA  Male Accessory Gland    123.5   228.25  Carcass    61.8 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    5 central nervous system, pupae P8    2 head, virgin 1-day female    3 head, virgin 4-day female    1 head, virgin 20-day female    4 head, mated 1-day female    2 head, mated 4-day female    1 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    3 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    89 digestive system, 1-day adult    230 digestive system, 4-day adult    140 digestive system, 20-day adult    139 fat body, larvae L3 wandering    18 fat body, white prepupae    18 fat body, pupae P8    26 carcass, larvae L3 wandering    8 carcass, 1-day adult    9 carcass, 4-day adult    7 carcass, 20-day adult    10 ovary, virgin 4-day female    14 ovary, mated 4-day female    8 testis, mated 4-day male    30 accessory gland, mated 4-day male    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    5 central nervous system, pupae P8    2 head, virgin 1-day female    3 head, virgin 4-day female    1 head, virgin 20-day female    4 head, mated 1-day female    2 head, mated 4-day female    1 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    3 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    4 digestive system, larvae L3 wandering  (89) digestive system, 1-day adult  (230) digestive system, 4-day adult  (140) digestive system, 20-day adult  (139) fat body, larvae L3 wandering    18 fat body, white prepupae    18 fat body, pupae P8  26 carcass, larvae L3 wandering    8 carcass, 1-day adult    9 carcass, 4-day adult    7 carcass, 20-day adult    10 ovary, virgin 4-day female    14 ovary, mated 4-day female    8 testis, mated 4-day male  (30) accessory gland, mated 4-day male    21 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    5 central nervous system, pupae P8    2 head, virgin 1-day female    3 head, virgin 4-day female    1 head, virgin 20-day female    4 head, mated 1-day female    2 head, mated 4-day female    1 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    3 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    89 digestive system, 1-day adult  (230) digestive system, 4-day adult  (140) digestive system, 20-day adult  (139) fat body, larvae L3 wandering    18 fat body, white prepupae    18 fat body, pupae P8    26 carcass, larvae L3 wandering    8 carcass, 1-day adult    9 carcass, 4-day adult    7 carcass, 20-day adult    10 ovary, virgin 4-day female    14 ovary, mated 4-day female    8 testis, mated 4-day male    30 accessory gland, mated 4-day male    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    5 central nervous system, pupae P8    2 head, virgin 1-day female    3 head, virgin 4-day female    1 head, virgin 20-day female    4 head, mated 1-day female    2 head, mated 4-day female    1 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    3 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    89 digestive system, 1-day adult    230 digestive system, 4-day adult    140 digestive system, 20-day adult    139 fat body, larvae L3 wandering    18 fat body, white prepupae    18 fat body, pupae P8    26 carcass, larvae L3 wandering    8 carcass, 1-day adult    9 carcass, 4-day adult    7 carcass, 20-day adult    10 ovary, virgin 4-day female    14 ovary, mated 4-day female    8 testis, mated 4-day male    30 accessory gland, mated 4-day male    21 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    5 central nervous system, pupae P8    2 head, virgin 1-day female    3 head, virgin 4-day female    1 head, virgin 20-day female    4 head, mated 1-day female    2 head, mated 4-day female    1 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    3 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    89 digestive system, 1-day adult    230 digestive system, 4-day adult    140 digestive system, 20-day adult    139 fat body, larvae L3 wandering    18 fat body, white prepupae    18 fat body, pupae P8    26 carcass, larvae L3 wandering    8 carcass, 1-day adult    9 carcass, 4-day adult    7 carcass, 20-day adult    10 ovary, virgin 4-day female    14 ovary, mated 4-day female    8 testis, mated 4-day male    30 accessory gland, mated 4-day male    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    5 central nervous system, pupae P8    2 head, virgin 1-day female    3 head, virgin 4-day female    1 head, virgin 20-day female    4 head, mated 1-day female    2 head, mated 4-day female    1 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    3 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    4 digestive system, larvae L3 wandering  (89) digestive system, 1-day adult  (230) digestive system, 4-day adult  (140) digestive system, 20-day adult  (139) fat body, larvae L3 wandering    18 fat body, white prepupae    18 fat body, pupae P8  26 carcass, larvae L3 wandering    8 carcass, 1-day adult    9 carcass, 4-day adult    7 carcass, 20-day adult    10 ovary, virgin 4-day female    14 ovary, mated 4-day female    8 testis, mated 4-day male  30 accessory gland, mated 4-day male    21 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    5 central nervous system, pupae P8    2 head, virgin 1-day female    3 head, virgin 4-day female    1 head, virgin 20-day female    4 head, mated 1-day female    2 head, mated 4-day female    1 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    3 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    89 digestive system, 1-day adult  (230) digestive system, 4-day adult  140 digestive system, 20-day adult  139 fat body, larvae L3 wandering    18 fat body, white prepupae    18 fat body, pupae P8    26 carcass, larvae L3 wandering    8 carcass, 1-day adult    9 carcass, 4-day adult    7 carcass, 20-day adult    10 ovary, virgin 4-day female    14 ovary, mated 4-day female    8 testis, mated 4-day male    30 accessory gland, mated 4-day male    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    5 central nervous system, pupae P8    2 head, virgin 1-day female    3 head, virgin 4-day female    1 head, virgin 20-day female    4 head, mated 1-day female    2 head, mated 4-day female    1 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    3 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    89 digestive system, 1-day adult    230 digestive system, 4-day adult    140 digestive system, 20-day adult    139 fat body, larvae L3 wandering    18 fat body, white prepupae    18 fat body, pupae P8    26 carcass, larvae L3 wandering    8 carcass, 1-day adult    9 carcass, 4-day adult    7 carcass, 20-day adult    10 ovary, virgin 4-day female    14 ovary, mated 4-day female    8 testis, mated 4-day male    30 accessory gland, mated 4-day male    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed during late larval stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    24 embryo 02-04hr    22 embryo 04-06hr    9 embryo 06-08hr    4 embryo 08-10hr    7 embryo 10-12hr    11 embryo 12-14hr    8 embryo 14-16hr    14 embryo 16-18hr    17 embryo 18-20hr    23 embryo 20-22hr    49 embryo 22-24hr    58 larva L1    106 larva L2    129 larva L3 12hr old    129 larva L3 puffstage 1-2    148 larva L3 puffstage 3-6    80 larva L3 puffstage 7-9    49 white prepupae new    31 white prepupae 12hr    18 white prepupae 24hr    21 pupae 2d postWPP    18 pupae 3d postWPP    16 pupae 4d postWPP    63 adult male 01day    94 adult male 05day    97 adult male 30day    114 adult female 01day    79 adult female 05day    57 adult female 30day    75 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    24 embryo 02-04hr    22 embryo 04-06hr    9 embryo 06-08hr    4 embryo 08-10hr    7 embryo 10-12hr    11 embryo 12-14hr    8 embryo 14-16hr    14 embryo 16-18hr    17 embryo 18-20hr    23 embryo 20-22hr  (49) embryo 22-24hr  (58) larva L1  (106) larva L2  (129) larva L3 12hr old  (129) larva L3 puffstage 1-2  (148) larva L3 puffstage 3-6  (80) larva L3 puffstage 7-9  (49) white prepupae new  (31) white prepupae 12hr    18 white prepupae 24hr    21 pupae 2d postWPP    18 pupae 3d postWPP    16 pupae 4d postWPP  (63) adult male 01day  (94) adult male 05day  (97) adult male 30day  (114) adult female 01day  (79) adult female 05day  (57) adult female 30day  (75) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    24 embryo 02-04hr    22 embryo 04-06hr    9 embryo 06-08hr    4 embryo 08-10hr    7 embryo 10-12hr    11 embryo 12-14hr    8 embryo 14-16hr    14 embryo 16-18hr    17 embryo 18-20hr    23 embryo 20-22hr    49 embryo 22-24hr    58 larva L1  106 larva L2  (129) larva L3 12hr old  (129) larva L3 puffstage 1-2  (148) larva L3 puffstage 3-6    80 larva L3 puffstage 7-9    49 white prepupae new    31 white prepupae 12hr    18 white prepupae 24hr    21 pupae 2d postWPP    18 pupae 3d postWPP    16 pupae 4d postWPP    63 adult male 01day    94 adult male 05day    97 adult male 30day  (114) adult female 01day    79 adult female 05day    57 adult female 30day    75 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    24 embryo 02-04hr    22 embryo 04-06hr    9 embryo 06-08hr    4 embryo 08-10hr    7 embryo 10-12hr    11 embryo 12-14hr    8 embryo 14-16hr    14 embryo 16-18hr    17 embryo 18-20hr    23 embryo 20-22hr    49 embryo 22-24hr    58 larva L1    106 larva L2    129 larva L3 12hr old    129 larva L3 puffstage 1-2    148 larva L3 puffstage 3-6    80 larva L3 puffstage 7-9    49 white prepupae new    31 white prepupae 12hr    18 white prepupae 24hr    21 pupae 2d postWPP    18 pupae 3d postWPP    16 pupae 4d postWPP    63 adult male 01day    94 adult male 05day    97 adult male 30day    114 adult female 01day    79 adult female 05day    57 adult female 30day    75 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    24 embryo 02-04hr    22 embryo 04-06hr    9 embryo 06-08hr    4 embryo 08-10hr    7 embryo 10-12hr    11 embryo 12-14hr    8 embryo 14-16hr    14 embryo 16-18hr    17 embryo 18-20hr    23 embryo 20-22hr    49 embryo 22-24hr    58 larva L1    106 larva L2    129 larva L3 12hr old    129 larva L3 puffstage 1-2    148 larva L3 puffstage 3-6    80 larva L3 puffstage 7-9    49 white prepupae new    31 white prepupae 12hr    18 white prepupae 24hr    21 pupae 2d postWPP    18 pupae 3d postWPP    16 pupae 4d postWPP    63 adult male 01day    94 adult male 05day    97 adult male 30day    114 adult female 01day    79 adult female 05day    57 adult female 30day    75 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    24 embryo 02-04hr    22 embryo 04-06hr    9 embryo 06-08hr    4 embryo 08-10hr    7 embryo 10-12hr    11 embryo 12-14hr    8 embryo 14-16hr    14 embryo 16-18hr    17 embryo 18-20hr    23 embryo 20-22hr  (49) embryo 22-24hr  (58) larva L1  (106) larva L2  (129) larva L3 12hr old  (129) larva L3 puffstage 1-2  (148) larva L3 puffstage 3-6  (80) larva L3 puffstage 7-9  (49) white prepupae new  31 white prepupae 12hr    18 white prepupae 24hr    21 pupae 2d postWPP    18 pupae 3d postWPP    16 pupae 4d postWPP  (63) adult male 01day  (94) adult male 05day  (97) adult male 30day  (114) adult female 01day  (79) adult female 05day  (57) adult female 30day  (75) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    24 embryo 02-04hr    22 embryo 04-06hr    9 embryo 06-08hr    4 embryo 08-10hr    7 embryo 10-12hr    11 embryo 12-14hr    8 embryo 14-16hr    14 embryo 16-18hr    17 embryo 18-20hr    23 embryo 20-22hr    49 embryo 22-24hr    58 larva L1  106 larva L2  129 larva L3 12hr old  129 larva L3 puffstage 1-2  (148) larva L3 puffstage 3-6    80 larva L3 puffstage 7-9    49 white prepupae new    31 white prepupae 12hr    18 white prepupae 24hr    21 pupae 2d postWPP    18 pupae 3d postWPP    16 pupae 4d postWPP    63 adult male 01day    94 adult male 05day    97 adult male 30day  114 adult female 01day    79 adult female 05day    57 adult female 30day    75 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    24 embryo 02-04hr    22 embryo 04-06hr    9 embryo 06-08hr    4 embryo 08-10hr    7 embryo 10-12hr    11 embryo 12-14hr    8 embryo 14-16hr    14 embryo 16-18hr    17 embryo 18-20hr    23 embryo 20-22hr    49 embryo 22-24hr    58 larva L1    106 larva L2    129 larva L3 12hr old    129 larva L3 puffstage 1-2    148 larva L3 puffstage 3-6    80 larva L3 puffstage 7-9    49 white prepupae new    31 white prepupae 12hr    18 white prepupae 24hr    21 pupae 2d postWPP    18 pupae 3d postWPP    16 pupae 4d postWPP    63 adult male 01day    94 adult male 05day    97 adult male 30day    114 adult female 01day    79 adult female 05day    57 adult female 30day    75 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    11 Schneider line 2 Sg4    13 embryonic 1182-4H    16 embryonic GM2    14 embryonic Kc167    9 embryonic S1    22 embryonic S3    28 leg disc CME L1    9 wing disc CME-W2    7 wing disc ML-DmD8    11 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    18 wing disc ML-DmD32    13 haltere disc ML-DmD17-c3    20 eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5    21 mixed discs ML-DmD4-c1    24 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    4 ovary fGS/OSS    8 ovary OSC    10 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    11 Schneider line 2 Sg4    13 embryonic 1182-4H    16 embryonic GM2    14 embryonic Kc167    9 embryonic S1    22 embryonic S3  (28) leg disc CME L1    9 wing disc CME-W2    7 wing disc ML-DmD8    11 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    18 wing disc ML-DmD32    13 haltere disc ML-DmD17-c3    20 eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5    21 mixed discs ML-DmD4-c1    24 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    4 ovary fGS/OSS    8 ovary OSC    10 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    11 Schneider line 2 Sg4    13 embryonic 1182-4H    16 embryonic GM2    14 embryonic Kc167    9 embryonic S1    22 embryonic S3    28 leg disc CME L1    9 wing disc CME-W2    7 wing disc ML-DmD8    11 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    18 wing disc ML-DmD32    13 haltere disc ML-DmD17-c3    20 eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5    21 mixed discs ML-DmD4-c1    24 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    4 ovary fGS/OSS    8 ovary OSC    10 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    11 Schneider line 2 Sg4    13 embryonic 1182-4H    16 embryonic GM2    14 embryonic Kc167    9 embryonic S1    22 embryonic S3    28 leg disc CME L1    9 wing disc CME-W2    7 wing disc ML-DmD8    11 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    18 wing disc ML-DmD32    13 haltere disc ML-DmD17-c3    20 eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5    21 mixed discs ML-DmD4-c1    24 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    4 ovary fGS/OSS    8 ovary OSC    10 ovary OSS    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    11 Schneider line 2 Sg4    13 embryonic 1182-4H    16 embryonic GM2    14 embryonic Kc167    9 embryonic S1    22 embryonic S3    28 leg disc CME L1    9 wing disc CME-W2    7 wing disc ML-DmD8    11 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    18 wing disc ML-DmD32    13 haltere disc ML-DmD17-c3    20 eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5    21 mixed discs ML-DmD4-c1    24 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    4 ovary fGS/OSS    8 ovary OSC    10 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    11 Schneider line 2 Sg4    13 embryonic 1182-4H    16 embryonic GM2    14 embryonic Kc167    9 embryonic S1    22 embryonic S3  28 leg disc CME L1    9 wing disc CME-W2    7 wing disc ML-DmD8    11 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    18 wing disc ML-DmD32    13 haltere disc ML-DmD17-c3    20 eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5    21 mixed discs ML-DmD4-c1    24 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    4 ovary fGS/OSS    8 ovary OSC    10 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    11 Schneider line 2 Sg4    13 embryonic 1182-4H    16 embryonic GM2    14 embryonic Kc167    9 embryonic S1    22 embryonic S3    28 leg disc CME L1    9 wing disc CME-W2    7 wing disc ML-DmD8    11 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    18 wing disc ML-DmD32    13 haltere disc ML-DmD17-c3    20 eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5    21 mixed discs ML-DmD4-c1    24 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    4 ovary fGS/OSS    8 ovary OSC    10 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    11 Schneider line 2 Sg4    13 embryonic 1182-4H    16 embryonic GM2    14 embryonic Kc167    9 embryonic S1    22 embryonic S3    28 leg disc CME L1    9 wing disc CME-W2    7 wing disc ML-DmD8    11 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    18 wing disc ML-DmD32    13 haltere disc ML-DmD17-c3    20 eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5    21 mixed discs ML-DmD4-c1    24 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    4 ovary fGS/OSS    8 ovary OSC    10 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    8 heat shock, 4-day adult    40 Cadmium 50 mM 6 hrs, larvae L3    65 Cadmium 50 mM 12 hrs, larvae L3    70 Cadmium 50 mM 48 hrs, 4-day adult    47 Cadmium 100 mM 48 hrs, 4-day adult    15 Copper 0.5 mM 12 hrs, larvae L3    33 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    24 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    83 Ethanol 10% 3 hrs, larvae L3    70 Caffeine 1.5 mg/ml 4 hrs, larvae L3    74 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    38 Paraquat 10 mM 48 hrs, 4-day adult    30 Rotenone 2 μg 12 hrs, larvae L3    69 Rotenone 8 μg 12 hrs, larvae L3    67 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    8 heat shock, 4-day adult  (40) Cadmium 50 mM 6 hrs, larvae L3  (65) Cadmium 50 mM 12 hrs, larvae L3  (70) Cadmium 50 mM 48 hrs, 4-day adult  (47) Cadmium 100 mM 48 hrs, 4-day adult    15 Copper 0.5 mM 12 hrs, larvae L3  (33) Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    24 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3  (83) Ethanol 10% 3 hrs, larvae L3  (70) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (74) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult  (38) Paraquat 10 mM 48 hrs, 4-day adult  (30) Rotenone 2 μg 12 hrs, larvae L3  (69) Rotenone 8 μg 12 hrs, larvae L3  (67) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    8 heat shock, 4-day adult    40 Cadmium 50 mM 6 hrs, larvae L3    65 Cadmium 50 mM 12 hrs, larvae L3    70 Cadmium 50 mM 48 hrs, 4-day adult    47 Cadmium 100 mM 48 hrs, 4-day adult    15 Copper 0.5 mM 12 hrs, larvae L3    33 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    24 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    83 Ethanol 10% 3 hrs, larvae L3    70 Caffeine 1.5 mg/ml 4 hrs, larvae L3    74 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    38 Paraquat 10 mM 48 hrs, 4-day adult    30 Rotenone 2 μg 12 hrs, larvae L3    69 Rotenone 8 μg 12 hrs, larvae L3    67 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    8 heat shock, 4-day adult    40 Cadmium 50 mM 6 hrs, larvae L3    65 Cadmium 50 mM 12 hrs, larvae L3    70 Cadmium 50 mM 48 hrs, 4-day adult    47 Cadmium 100 mM 48 hrs, 4-day adult    15 Copper 0.5 mM 12 hrs, larvae L3    33 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    24 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    83 Ethanol 10% 3 hrs, larvae L3    70 Caffeine 1.5 mg/ml 4 hrs, larvae L3    74 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    38 Paraquat 10 mM 48 hrs, 4-day adult    30 Rotenone 2 μg 12 hrs, larvae L3    69 Rotenone 8 μg 12 hrs, larvae L3    67 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    8 heat shock, 4-day adult    40 Cadmium 50 mM 6 hrs, larvae L3    65 Cadmium 50 mM 12 hrs, larvae L3    70 Cadmium 50 mM 48 hrs, 4-day adult    47 Cadmium 100 mM 48 hrs, 4-day adult    15 Copper 0.5 mM 12 hrs, larvae L3    33 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    24 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    83 Ethanol 10% 3 hrs, larvae L3    70 Caffeine 1.5 mg/ml 4 hrs, larvae L3    74 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    38 Paraquat 10 mM 48 hrs, 4-day adult    30 Rotenone 2 μg 12 hrs, larvae L3    69 Rotenone 8 μg 12 hrs, larvae L3    67 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    8 heat shock, 4-day adult  (40) Cadmium 50 mM 6 hrs, larvae L3  (65) Cadmium 50 mM 12 hrs, larvae L3  (70) Cadmium 50 mM 48 hrs, 4-day adult  (47) Cadmium 100 mM 48 hrs, 4-day adult    15 Copper 0.5 mM 12 hrs, larvae L3  (33) Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    24 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3  (83) Ethanol 10% 3 hrs, larvae L3  (70) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (74) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult  (38) Paraquat 10 mM 48 hrs, 4-day adult  30 Rotenone 2 μg 12 hrs, larvae L3  (69) Rotenone 8 μg 12 hrs, larvae L3  (67) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    8 heat shock, 4-day adult    40 Cadmium 50 mM 6 hrs, larvae L3    65 Cadmium 50 mM 12 hrs, larvae L3    70 Cadmium 50 mM 48 hrs, 4-day adult    47 Cadmium 100 mM 48 hrs, 4-day adult    15 Copper 0.5 mM 12 hrs, larvae L3    33 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    24 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    83 Ethanol 10% 3 hrs, larvae L3    70 Caffeine 1.5 mg/ml 4 hrs, larvae L3    74 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    38 Paraquat 10 mM 48 hrs, 4-day adult    30 Rotenone 2 μg 12 hrs, larvae L3    69 Rotenone 8 μg 12 hrs, larvae L3    67 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    8 heat shock, 4-day adult    40 Cadmium 50 mM 6 hrs, larvae L3    65 Cadmium 50 mM 12 hrs, larvae L3    70 Cadmium 50 mM 48 hrs, 4-day adult    47 Cadmium 100 mM 48 hrs, 4-day adult    15 Copper 0.5 mM 12 hrs, larvae L3    33 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    24 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    83 Ethanol 10% 3 hrs, larvae L3    70 Caffeine 1.5 mg/ml 4 hrs, larvae L3    74 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    38 Paraquat 10 mM 48 hrs, 4-day adult    30 Rotenone 2 μg 12 hrs, larvae L3    69 Rotenone 8 μg 12 hrs, larvae L3    67 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_10 mE1_20_mRNA_expression_cluster_15
External Data & Images
Linkouts	BDGP expression data • RE13549 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039049 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6726-RB FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for CG6726 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG6726GD10651 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of CG6726 Class Mutagen Stocks Known lesion CG6726DG39212 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG6726 Class Mutagen Stocks Known lesion CG6726GD10651 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG6726GL01122 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG6726KK103421 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG6726NIG.6726R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6193 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD10651} NA P{KK103421} NA P{NIG.6726R} NA P{TRiP.GL01122} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{wHy}CG6726DG39212 NA PBac{RB}CG13830e03146 NA
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
NOT aminoacylase activity non-traceable author statement (FlyBase, 1992-) aminoacylase activity inferred from electronic annotation with InterPro:IPR010159 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
cellular amino acid metabolic process inferred from electronic annotation with InterPro:IPR010159 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
cytoplasm inferred from electronic annotation with InterPro:IPR010159 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
CG6726 - CG4933 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6726 - CG6465 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) CG6726 - Crc experimental knowledge based (Guruharsha et al., 2011) CG6726 - Gip experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) CG6726 - loqs experimental knowledge based (Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG6726 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67673 DroID - A comprehensive database of gene and protein interactions. • FBgn0039049 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42728
Orthologs
OrthoDB Orthologs (54) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6R24DR Dipteran inclusive ortholog search EOG634WFK Insect inclusive ortholog search EOG6SF82B Arthropod inclusive ortholog search EOG68CZ9S Metazoa inclusive ortholog search EOG66MQC3
Orthologs in Drosophila Species (EOG6R24DR)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG6726     Drosophila simulans   Dsim\GD20996     Drosophila sechellia   Dsec\GM26483     Drosophila erecta   Dere\GG11184     Drosophila yakuba   Dyak\GE10351     Drosophila ananassae   Dana\GF16975     Drosophila pseudoobscura pseudoobscura   Dpse\GA19815     Drosophila persimilis   Dper\GL13662     Drosophila willistoni   Dwil\GK14410     Drosophila virilis   Dvir\GJ24611     Drosophila mojavensis   Dmoj\GI23017 Y   Drosophila grimshawi   Dgri\GH23739
Orthologs in non-Drosophila Dipterans (EOG634WFK)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL011206 Y Anopheles gambiae Malaria mosquito  Agam\AGAP000679 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ013669 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ013670 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ009804 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ013671 Y
Orthologs in non-Dipteran Insects (EOG6SF82B)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC408969 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG014144 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH12440 Y Atta cephalotes Leafcutter ant  Acep\ACEP14422 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO23461 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO23227 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL18649 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL18648 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL15518 Y Linepithema humile Argentine ant  Lhum\LH15213 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB20516 Y Solenopsis invicta Red fire ant  Sinv\SINV24105 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI003420 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI006254 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI009740 Y Bombyx mori Silkmoth  Bmor\BGIBMGA010352 Y Pediculus humanus Human body louse  Phum\PHUM047660 Y Tribolium castaneum Red flour beetle  Tcas\TC012531 Y Tribolium castaneum Red flour beetle  Tcas\TC012530 Y Tribolium castaneum Red flour beetle  Tcas\TC012529 Y
Orthologs in non-Insect Arthropods (EOG68CZ9S)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Hrb87F Y Daphnia pulex Water flea  Dpux\JGI_V11_48442 Y Ixodes scapularis Deer tick  Isca\ISCW020050 Y
Orthologs in non-Arthropod Metazoa (EOG66MQC3)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\C10C5.5 Y Caenorhabditis elegans Nematode  Cele\C10C5.3 Y Caenorhabditis elegans Nematode  Cele\C10C5.4 Y Caenorhabditis elegans Nematode  Cele\C06A6.4 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_010120gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_015090gn Y Danio rerio Zebrafish  Drer\CU896698.1 Y Danio rerio Zebrafish  Drer\ENSDARG00000038475 Y Xenopus tropicalis Western clawed frog  Xtro\acy1.1 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000032120 Y Mus musculus House mouse  Mmus\ENSMUSG00000023262 Y Rattus norvegicus Norway rat  Rnor\Acy1a Y Homo sapiens Human  Hsap\ACY1 Y
Human Orthologs (1)
Gene OMIM HGNC Hsap\ACY1
AAA Orthologs (1) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila mojavensis Dmoj\GI23017
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	38189 y1 sc* v1; P{TRiP.GL01122}attP2 21777 y1 w67c23; P{wHy}CG6726DG39212 CG13830DG39212
VDRC	v108360 P{KK103421}VIE-260B v34247 w1118; P{GD10651}v34247
Genomic Clones ( 1 )
	BACR17P04 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 110 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE13549
Other clones	DPiM_RE13549
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD02530 LP11519 LP23229 RE46493 RE64284
Other clones	CK01307 Dmel_dig_019348_0658_1399 EC25824 EC33250 EC052228 EC052232 EC053254 EC056530 RP003012666 RP003025260 RP003040103 RP003046461 RP003049673 RP003061845 RP003068315 RP003084613 RP003101141 RP003132670 RP003138276 RP003142095 RP003146847 RP003151578 RP003153498 RP003162448 RP003179817 RP003188432 RP003196204 RP003199483 RP003208781 RP003208793 RP003210898 RP003211386 RP003216942 RP003232395 RP003233932 RP003239181 RP003239994 RP003245870 RP003246670 RP003258309 RP003265704 RP003269213 RP003279178 RP003286193 RP003292633 RP003295999 RP003297096 RP003301823 RP003304887 RP003304980 RP003307781 RP003311623 RP003312900 RP003328096 RP003328307 RP003336860 RP003337056 RP003348553 RP003385444 RP003394522 RP003396857 RP003421512 RP003431754 RP003436246 RP003450108 RP003459692 RP003469186 RP003472203 RP003475966 RP003485024 RP003490384 RP003501835 RP003505673 RP003507257 RP003510165 RP003532221 RP003539137 RP003543743 RP003548719 RP003550454 RP003550488 RP003564288 RP003572900 RP003575971 RP003586474 RP003588116 RP003595701 RP003596261 RP003601869 RP003610887 RP003627579 RP003630032 RP003634489 RP003638251 RP003638672 RP003640857 RP003652562 RP003655787 RP003660716 RP003663739 RP003667334 RP003670159 RP003677718
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0039049 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42728
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_142863 NM_170048 RefSeq (Proteins) • NP_651120 NP_732822 DDBJ / EMBL / GenBank • AAF56094 AAM50281 AAN13926 AY119627 BI171719 Entrez Gene - A searchable database of RefSeq genes. • 42728 UniProtKB/TrEMBL • Q7JUX5 Q9VCR2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Peptidase M20 (IPR002933) N-acyl-L-amino-acid amidohydrolase (IPR010159) Peptidase M20, dimerisation domain (IPR011650) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE13549
Linkouts
	BioGRID - A database of protein and genetic interactions • 67673 DroID - A comprehensive database of gene and protein interactions. • FBgn0039049 DRSC - Results from RNAi screens. • FBgn0039049 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039049 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6726-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0039049 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42728 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42728 modMine - Data generated by the modENCODE project. • FBgn0039049
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG6726 (Wang et al., 2004, Ni et al., 2011.7.19, Roxstrom-Lindquist et al., 2004, Keleman et al., 2009.8.5, Japanese National Institute of Genetics, 2012.5.21)
Name Synonym
Secondary FlyBase IDs
References ( 22 )
Generate a list of	All references relating to this gene ( 22 )
List References by type	Research paper  ( 3 ) Supplementary material  ( 5 ) Personal communication to FlyBase  ( 9 ) FlyBase analysis  ( 1 ) Stock list  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2011 Show research papers ...