Gene Dmel\CG17109

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General Information

Symbol

Dmel\CG17109

Species

D. melanogaster

Name

Annotation symbol

CG17109

Feature type

protein_coding_gene

FlyBase ID

FBgn0039051

Gene Model Status

Current

Stock availability

5 publicly available

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

94D13-94D13

Sequence location

3R:18,921,412..18,922,962 [+]

Genomic Maps

Select View:

Summary Information

Automatically generated summary

See sections below for more information

This gene is referred to in FlyBase by the symbol Dmel\CG17109 (FBgn0039051). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: aminoacylase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: cellular amino acid metabolic process. 4 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: N-acyl-L-amino-acid amidohydrolase; Peptidase M20; Peptidase M20, dimerisation domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed within 18-24 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval/adult midgut, larval Malpighian tubules. Expression at moderate levels in the following post-embryonic organs or tissues: adult Malpighian tubules, adult heart. Comments on Affy2 ProbeSet: ProbeSet 1639391_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG17109. Gene sequence location is 3R:18921412..18922962.

User Contributed Data

Beta version, feedback welcome

Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

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FB2013_03

FB2013_02

All updates

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Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

94D13-94D13

Limits computationally determined from genome sequence between P{lacW}Gclm^L0580 and P{EP}hh^EP3521

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Gene Model & Products

Please see the GBrowse view of Dmel\CG17109 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Comments on Gene Model

Gene model reviewed during 5.48

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

CG17109-RA

FBtr0084351

NM_142865

1313

400

CG17109-RB

FBtr0337027

NM_001275930

1373

400

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

CG17109-PA

FBpp0083744

45.0

400

4.69

NP_651122

AAF56096

CG17109-PB

FBpp0307956

45.0

400

4.69

NP_001262859

AGB96239

Additional Polypeptide Data & Comments

Reported size (kDa)

Comments

External Data

Linkouts

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Peptidase M20 (IPR002933)

N-acyl-L-amino-acid amidohydrolase (IPR010159)

Peptidase M20, dimerisation domain (IPR011650)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Mapped Features

Mapped Features have been reorganized, please see this article for details.

Additional mapped features and mutations can be found on GBrowse or related reports.

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 11 -- 12

procrystal cell

(Fisher et al., 2012)

embryonic stage 13 -- 16

crystal cell

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization (GO Cellular Component)

CV term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

Reference

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

FlyAtlas Anatomy Microarray

FlyAtlas Anatomical Expression Data

(FlyAtlas-RNA.adult)

(FlyAtlas-RNA.larva)

	Styles
	Linear
	Logarithmic
	Heatmap
	Back-to-back
	Scales
	gene max expression
	Moderate expression bin max
	High level expression bin max
	Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval/adult midgut, larval Malpighian tubules. Expression at moderate levels in the following post-embryonic organs or tissues: adult Malpighian tubules, adult heart.
[download data (TSV)]

Guide to FlyAtlas expression level colors
	No expression (0 - 9.999)
	Low expression (10 - 99.999)
	Moderate expression (100 - 499.999)
	High level expression (500 - 999.999)
	Very high expression (>999.999)

Linear, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		9.1
Larval Midgut		850.7
Larval Hindgut		17.5
Larval Malpighian Tubules		733.5
Larval Fat Body		47.1
Larval Salivary Gland		10.4
Larval Trachea		31.275
Larval Carcass		94.325
Adult Head		43.8
Adult Eye		11.25
Adult Brain		14.8
Adult Thoracic-Abdominal Ganglion		14.4
Adult Crop		9.2
Adult Midgut		599.3
Adult Hindgut		5.9
Adult Malpighian Tubules		127.5
Adult Fat Body		15.6
Adult Salivary Gland		10.1
Adult Heart		265.125
Adult VirginFemale Spermatheca		13.4
Adult InseminatedFemale Spermatheca		10.6
Adult Ovary		3.1
Adult Testis		11.6
Adult Male Accessory Gland		12.6
Adult Carcass		39.1
Expression Level Scale		None Low Moderate High

Linear, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		9.1
Larval Midgut		(850.7)
Larval Hindgut		17.5
Larval Malpighian Tubules		(733.5)
Larval Fat Body		47.1
Larval Salivary Gland		10.4
Larval Trachea		31.275
Larval Carcass		94.325
Adult Head		43.8
Adult Eye		11.25
Adult Brain		14.8
Adult Thoracic-Abdominal Ganglion		14.4
Adult Crop		9.2
Adult Midgut		(599.3)
Adult Hindgut		5.9
Adult Malpighian Tubules		127.5
Adult Fat Body		15.6
Adult Salivary Gland		10.1
Adult Heart		265.125
Adult VirginFemale Spermatheca		13.4
Adult InseminatedFemale Spermatheca		10.6
Adult Ovary		3.1
Adult Testis		11.6
Adult Male Accessory Gland		12.6
Adult Carcass		39.1
Expression Level Scale		None Low Moderate High

Linear, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		9.1
Larval Midgut		850.7
Larval Hindgut		17.5
Larval Malpighian Tubules		733.5
Larval Fat Body		47.1
Larval Salivary Gland		10.4
Larval Trachea		31.275
Larval Carcass		94.325
Adult Head		43.8
Adult Eye		11.25
Adult Brain		14.8
Adult Thoracic-Abdominal Ganglion		14.4
Adult Crop		9.2
Adult Midgut		599.3
Adult Hindgut		5.9
Adult Malpighian Tubules		127.5
Adult Fat Body		15.6
Adult Salivary Gland		10.1
Adult Heart		265.125
Adult VirginFemale Spermatheca		13.4
Adult InseminatedFemale Spermatheca		10.6
Adult Ovary		3.1
Adult Testis		11.6
Adult Male Accessory Gland		12.6
Adult Carcass		39.1
Expression Level Scale		None Low Moderate High Very high

Linear, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		9.1
Larval Midgut		850.7
Larval Hindgut		17.5
Larval Malpighian Tubules		733.5
Larval Fat Body		47.1
Larval Salivary Gland		10.4
Larval Trachea		31.275
Larval Carcass		94.325
Adult Head		43.8
Adult Eye		11.25
Adult Brain		14.8
Adult Thoracic-Abdominal Ganglion		14.4
Adult Crop		9.2
Adult Midgut		599.3
Adult Hindgut		5.9
Adult Malpighian Tubules		127.5
Adult Fat Body		15.6
Adult Salivary Gland		10.1
Adult Heart		265.125
Adult VirginFemale Spermatheca		13.4
Adult InseminatedFemale Spermatheca		10.6
Adult Ovary		3.1
Adult Testis		11.6
Adult Male Accessory Gland		12.6
Adult Carcass		39.1
Expression Level Scale		Very high

log, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		9.1
Larval Midgut		850.7
Larval Hindgut		17.5
Larval Malpighian Tubules		733.5
Larval Fat Body		47.1
Larval Salivary Gland		10.4
Larval Trachea		31.275
Larval Carcass		94.325
Adult Head		43.8
Adult Eye		11.25
Adult Brain		14.8
Adult Thoracic-Abdominal Ganglion		14.4
Adult Crop		9.2
Adult Midgut		599.3
Adult Hindgut		5.9
Adult Malpighian Tubules		127.5
Adult Fat Body		15.6
Adult Salivary Gland		10.1
Adult Heart		265.125
Adult VirginFemale Spermatheca		13.4
Adult InseminatedFemale Spermatheca		10.6
Adult Ovary		3.1
Adult Testis		11.6
Adult Male Accessory Gland		12.6
Adult Carcass		39.1
Expression Level Scale		None Low Moderate High Very high

log, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		9.1
Larval Midgut		(850.7)
Larval Hindgut		17.5
Larval Malpighian Tubules		733.5
Larval Fat Body		47.1
Larval Salivary Gland		10.4
Larval Trachea		31.275
Larval Carcass		94.325
Adult Head		43.8
Adult Eye		11.25
Adult Brain		14.8
Adult Thoracic-Abdominal Ganglion		14.4
Adult Crop		9.2
Adult Midgut		599.3
Adult Hindgut		5.9
Adult Malpighian Tubules		127.5
Adult Fat Body		15.6
Adult Salivary Gland		10.1
Adult Heart		265.125
Adult VirginFemale Spermatheca		13.4
Adult InseminatedFemale Spermatheca		10.6
Adult Ovary		3.1
Adult Testis		11.6
Adult Male Accessory Gland		12.6
Adult Carcass		39.1
Expression Level Scale		None Low Moderate High

log, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		9.1
Larval Midgut		850.7
Larval Hindgut		17.5
Larval Malpighian Tubules		733.5
Larval Fat Body		47.1
Larval Salivary Gland		10.4
Larval Trachea		31.275
Larval Carcass		94.325
Adult Head		43.8
Adult Eye		11.25
Adult Brain		14.8
Adult Thoracic-Abdominal Ganglion		14.4
Adult Crop		9.2
Adult Midgut		599.3
Adult Hindgut		5.9
Adult Malpighian Tubules		127.5
Adult Fat Body		15.6
Adult Salivary Gland		10.1
Adult Heart		265.125
Adult VirginFemale Spermatheca		13.4
Adult InseminatedFemale Spermatheca		10.6
Adult Ovary		3.1
Adult Testis		11.6
Adult Male Accessory Gland		12.6
Adult Carcass		39.1
Expression Level Scale		None Low Moderate High Very high

log, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		9.1
Larval Midgut		850.7
Larval Hindgut		17.5
Larval Malpighian Tubules		733.5
Larval Fat Body		47.1
Larval Salivary Gland		10.4
Larval Trachea		31.275
Larval Carcass		94.325
Adult Head		43.8
Adult Eye		11.25
Adult Brain		14.8
Adult Thoracic-Abdominal Ganglion		14.4
Adult Crop		9.2
Adult Midgut		599.3
Adult Hindgut		5.9
Adult Malpighian Tubules		127.5
Adult Fat Body		15.6
Adult Salivary Gland		10.1
Adult Heart		265.125
Adult VirginFemale Spermatheca		13.4
Adult InseminatedFemale Spermatheca		10.6
Adult Ovary		3.1
Adult Testis		11.6
Adult Male Accessory Gland		12.6
Adult Carcass		39.1
Expression Level Scale		None Low Moderate High Very high

Heatmap
Tissue		Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level	Tissue	Adult Expression Level
NA	Head	43.8
NA	Eye	no informative data
NA	Brain	14.8
9.1	Central Nervous System	NA
NA	Thoracic-Abdominal Ganglion	no informative data
NA	Crop	9.2
850.7	Midgut	599.3
no informative data	Hindgut	5.9
733.5	Malpighian Tubules	127.5
47.1	Fat Body	no informative data
no informative data	Salivary Gland	no informative data
NA	Heart	265.125
31.275	Trachea	NA
NA	VirginFemale Spermatheca	no informative data
NA	InseminatedFemale Spermatheca	no informative data
NA	Ovary	3.1
NA	Testis	11.6
NA	Male Accessory Gland	no informative data
94.325	Carcass	39.1

FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)

modENCODE Anatomy RNA-Seq

modENCODE Tissue Expression Data

(modENCODE_mRNA-Seq_tissues)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		7
central nervous system, larvae L3		0
central nervous system, pupae P8		0
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		1
head, mated 4-day female		1
head, mated 20-day female		1
head, mated 1-day male		0
head, mated 4-day male		2
head, mated 20-day male		1
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		24
digestive system, 1-day adult		45
digestive system, 4-day adult		36
digestive system, 20-day adult		39
fat body, larvae L3 wandering		6
fat body, white prepupae		0
fat body, pupae P8		0
carcass, larvae L3 wandering		0
carcass, 1-day adult		0
carcass, 4-day adult		1
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		1
accessory gland, mated 4-day male		1
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		7
central nervous system, larvae L3		0
central nervous system, pupae P8		0
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		1
head, mated 4-day female		1
head, mated 20-day female		1
head, mated 1-day male		0
head, mated 4-day male		2
head, mated 20-day male		1
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		24
digestive system, 1-day adult		(45)
digestive system, 4-day adult		(36)
digestive system, 20-day adult		(39)
fat body, larvae L3 wandering		6
fat body, white prepupae		0
fat body, pupae P8		0
carcass, larvae L3 wandering		0
carcass, 1-day adult		0
carcass, 4-day adult		1
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		1
accessory gland, mated 4-day male		1
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		7
central nervous system, larvae L3		0
central nervous system, pupae P8		0
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		1
head, mated 4-day female		1
head, mated 20-day female		1
head, mated 1-day male		0
head, mated 4-day male		2
head, mated 20-day male		1
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		24
digestive system, 1-day adult		45
digestive system, 4-day adult		36
digestive system, 20-day adult		39
fat body, larvae L3 wandering		6
fat body, white prepupae		0
fat body, pupae P8		0
carcass, larvae L3 wandering		0
carcass, 1-day adult		0
carcass, 4-day adult		1
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		1
accessory gland, mated 4-day male		1
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		7
central nervous system, larvae L3		0
central nervous system, pupae P8		0
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		1
head, mated 4-day female		1
head, mated 20-day female		1
head, mated 1-day male		0
head, mated 4-day male		2
head, mated 20-day male		1
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		24
digestive system, 1-day adult		45
digestive system, 4-day adult		36
digestive system, 20-day adult		39
fat body, larvae L3 wandering		6
fat body, white prepupae		0
fat body, pupae P8		0
carcass, larvae L3 wandering		0
carcass, 1-day adult		0
carcass, 4-day adult		1
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		1
accessory gland, mated 4-day male		1
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		7
central nervous system, larvae L3		0
central nervous system, pupae P8		0
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		1
head, mated 4-day female		1
head, mated 20-day female		1
head, mated 1-day male		0
head, mated 4-day male		2
head, mated 20-day male		1
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		24
digestive system, 1-day adult		45
digestive system, 4-day adult		36
digestive system, 20-day adult		39
fat body, larvae L3 wandering		6
fat body, white prepupae		0
fat body, pupae P8		0
carcass, larvae L3 wandering		0
carcass, 1-day adult		0
carcass, 4-day adult		1
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		1
accessory gland, mated 4-day male		1
Expression Level Scale		Very low Low Moderate Moderately high High

log, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		7
central nervous system, larvae L3		0
central nervous system, pupae P8		0
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		1
head, mated 4-day female		1
head, mated 20-day female		1
head, mated 1-day male		0
head, mated 4-day male		2
head, mated 20-day male		1
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		24
digestive system, 1-day adult		(45)
digestive system, 4-day adult		(36)
digestive system, 20-day adult		(39)
fat body, larvae L3 wandering		6
fat body, white prepupae		0
fat body, pupae P8		0
carcass, larvae L3 wandering		0
carcass, 1-day adult		0
carcass, 4-day adult		1
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		1
accessory gland, mated 4-day male		1
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		7
central nervous system, larvae L3		0
central nervous system, pupae P8		0
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		1
head, mated 4-day female		1
head, mated 20-day female		1
head, mated 1-day male		0
head, mated 4-day male		2
head, mated 20-day male		1
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		24
digestive system, 1-day adult		45
digestive system, 4-day adult		36
digestive system, 20-day adult		39
fat body, larvae L3 wandering		6
fat body, white prepupae		0
fat body, pupae P8		0
carcass, larvae L3 wandering		0
carcass, 1-day adult		0
carcass, 4-day adult		1
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		1
accessory gland, mated 4-day male		1
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		7
central nervous system, larvae L3		0
central nervous system, pupae P8		0
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		1
head, mated 4-day female		1
head, mated 20-day female		1
head, mated 1-day male		0
head, mated 4-day male		2
head, mated 20-day male		1
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		24
digestive system, 1-day adult		45
digestive system, 4-day adult		36
digestive system, 20-day adult		39
fat body, larvae L3 wandering		6
fat body, white prepupae		0
fat body, pupae P8		0
carcass, larvae L3 wandering		0
carcass, 1-day adult		0
carcass, 4-day adult		1
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		1
accessory gland, mated 4-day male		1
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Tissue		Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male

modENCODE Development RNA-Seq

modENCODE Temporal Expression Data

(modENCODE_mRNA-Seq_U)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed within 18-24 hour embryonic stages.
[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		1
embryo 10-12hr		3
embryo 12-14hr		4
embryo 14-16hr		15
embryo 16-18hr		32
embryo 18-20hr		55
embryo 20-22hr		203
embryo 22-24hr		194
larva L1		107
larva L2		85
larva L3 12hr old		69
larva L3 puffstage 1-2		55
larva L3 puffstage 3-6		19
larva L3 puffstage 7-9		7
white prepupae new		2
white prepupae 12hr		1
white prepupae 24hr		0
pupae 2d postWPP		1
pupae 3d postWPP		0
pupae 4d postWPP		8
adult male 01day		12
adult male 05day		14
adult male 30day		11
adult female 01day		17
adult female 05day		6
adult female 30day		8
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		1
embryo 10-12hr		3
embryo 12-14hr		4
embryo 14-16hr		15
embryo 16-18hr		(32)
embryo 18-20hr		(55)
embryo 20-22hr		(203)
embryo 22-24hr		(194)
larva L1		(107)
larva L2		(85)
larva L3 12hr old		(69)
larva L3 puffstage 1-2		(55)
larva L3 puffstage 3-6		19
larva L3 puffstage 7-9		7
white prepupae new		2
white prepupae 12hr		1
white prepupae 24hr		0
pupae 2d postWPP		1
pupae 3d postWPP		0
pupae 4d postWPP		8
adult male 01day		12
adult male 05day		14
adult male 30day		11
adult female 01day		17
adult female 05day		6
adult female 30day		8
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		1
embryo 10-12hr		3
embryo 12-14hr		4
embryo 14-16hr		15
embryo 16-18hr		32
embryo 18-20hr		55
embryo 20-22hr		(203)
embryo 22-24hr		(194)
larva L1		107
larva L2		85
larva L3 12hr old		69
larva L3 puffstage 1-2		55
larva L3 puffstage 3-6		19
larva L3 puffstage 7-9		7
white prepupae new		2
white prepupae 12hr		1
white prepupae 24hr		0
pupae 2d postWPP		1
pupae 3d postWPP		0
pupae 4d postWPP		8
adult male 01day		12
adult male 05day		14
adult male 30day		11
adult female 01day		17
adult female 05day		6
adult female 30day		8
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		1
embryo 10-12hr		3
embryo 12-14hr		4
embryo 14-16hr		15
embryo 16-18hr		32
embryo 18-20hr		55
embryo 20-22hr		203
embryo 22-24hr		194
larva L1		107
larva L2		85
larva L3 12hr old		69
larva L3 puffstage 1-2		55
larva L3 puffstage 3-6		19
larva L3 puffstage 7-9		7
white prepupae new		2
white prepupae 12hr		1
white prepupae 24hr		0
pupae 2d postWPP		1
pupae 3d postWPP		0
pupae 4d postWPP		8
adult male 01day		12
adult male 05day		14
adult male 30day		11
adult female 01day		17
adult female 05day		6
adult female 30day		8
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		1
embryo 10-12hr		3
embryo 12-14hr		4
embryo 14-16hr		15
embryo 16-18hr		32
embryo 18-20hr		55
embryo 20-22hr		203
embryo 22-24hr		194
larva L1		107
larva L2		85
larva L3 12hr old		69
larva L3 puffstage 1-2		55
larva L3 puffstage 3-6		19
larva L3 puffstage 7-9		7
white prepupae new		2
white prepupae 12hr		1
white prepupae 24hr		0
pupae 2d postWPP		1
pupae 3d postWPP		0
pupae 4d postWPP		8
adult male 01day		12
adult male 05day		14
adult male 30day		11
adult female 01day		17
adult female 05day		6
adult female 30day		8
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		1
embryo 10-12hr		3
embryo 12-14hr		4
embryo 14-16hr		15
embryo 16-18hr		32
embryo 18-20hr		(55)
embryo 20-22hr		(203)
embryo 22-24hr		(194)
larva L1		(107)
larva L2		(85)
larva L3 12hr old		(69)
larva L3 puffstage 1-2		(55)
larva L3 puffstage 3-6		19
larva L3 puffstage 7-9		7
white prepupae new		2
white prepupae 12hr		1
white prepupae 24hr		0
pupae 2d postWPP		1
pupae 3d postWPP		0
pupae 4d postWPP		8
adult male 01day		12
adult male 05day		14
adult male 30day		11
adult female 01day		17
adult female 05day		6
adult female 30day		8
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		1
embryo 10-12hr		3
embryo 12-14hr		4
embryo 14-16hr		15
embryo 16-18hr		32
embryo 18-20hr		55
embryo 20-22hr		(203)
embryo 22-24hr		(194)
larva L1		107
larva L2		85
larva L3 12hr old		69
larva L3 puffstage 1-2		55
larva L3 puffstage 3-6		19
larva L3 puffstage 7-9		7
white prepupae new		2
white prepupae 12hr		1
white prepupae 24hr		0
pupae 2d postWPP		1
pupae 3d postWPP		0
pupae 4d postWPP		8
adult male 01day		12
adult male 05day		14
adult male 30day		11
adult female 01day		17
adult female 05day		6
adult female 30day		8
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		1
embryo 10-12hr		3
embryo 12-14hr		4
embryo 14-16hr		15
embryo 16-18hr		32
embryo 18-20hr		55
embryo 20-22hr		203
embryo 22-24hr		194
larva L1		107
larva L2		85
larva L3 12hr old		69
larva L3 puffstage 1-2		55
larva L3 puffstage 3-6		19
larva L3 puffstage 7-9		7
white prepupae new		2
white prepupae 12hr		1
white prepupae 24hr		0
pupae 2d postWPP		1
pupae 3d postWPP		0
pupae 4d postWPP		8
adult male 01day		12
adult male 05day		14
adult male 30day		11
adult female 01day		17
adult female 05day		6
adult female 30day		8
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Developmental Stage		Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day

modENCODE Temporal Expression Data (Graveley et al., 2011)

modENCODE Cell Lines RNA-Seq

modENCODE Cell Line Expression Data

(modENCODE_mRNA-Seq_cell.A)

(modENCODE_mRNA-Seq_cell.B)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		0
Schneider line 2 Sg4		1
embryonic 1182-4H		0
embryonic GM2		70
embryonic Kc167		0
embryonic S1		3
embryonic S3		0
leg disc CME L1		1
wing disc CME-W2		1
wing disc ML-DmD8		0
wing disc ML-DmD9		0
wing disc ML-DmD16-c3		15
wing disc ML-DmD21		1
wing disc ML-DmD32		0
haltere disc ML-DmD17-c3		0
eye-antennal disc ML-DmD11		0
antennal disc ML-DmD20-c5		0
mixed discs ML-DmD4-c1		0
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		0
tumorous blood cells mbn2		0
ovary fGS/OSS		0
ovary OSC		0
ovary OSS		0
Expression Level Scale		Very low Low Moderate Moderately high High

Linear, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		0
Schneider line 2 Sg4		1
embryonic 1182-4H		0
embryonic GM2		(70)
embryonic Kc167		0
embryonic S1		3
embryonic S3		0
leg disc CME L1		1
wing disc CME-W2		1
wing disc ML-DmD8		0
wing disc ML-DmD9		0
wing disc ML-DmD16-c3		15
wing disc ML-DmD21		1
wing disc ML-DmD32		0
haltere disc ML-DmD17-c3		0
eye-antennal disc ML-DmD11		0
antennal disc ML-DmD20-c5		0
mixed discs ML-DmD4-c1		0
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		0
tumorous blood cells mbn2		0
ovary fGS/OSS		0
ovary OSC		0
ovary OSS		0
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		0
Schneider line 2 Sg4		1
embryonic 1182-4H		0
embryonic GM2		70
embryonic Kc167		0
embryonic S1		3
embryonic S3		0
leg disc CME L1		1
wing disc CME-W2		1
wing disc ML-DmD8		0
wing disc ML-DmD9		0
wing disc ML-DmD16-c3		15
wing disc ML-DmD21		1
wing disc ML-DmD32		0
haltere disc ML-DmD17-c3		0
eye-antennal disc ML-DmD11		0
antennal disc ML-DmD20-c5		0
mixed discs ML-DmD4-c1		0
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		0
tumorous blood cells mbn2		0
ovary fGS/OSS		0
ovary OSC		0
ovary OSS		0
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		0
Schneider line 2 Sg4		1
embryonic 1182-4H		0
embryonic GM2		70
embryonic Kc167		0
embryonic S1		3
embryonic S3		0
leg disc CME L1		1
wing disc CME-W2		1
wing disc ML-DmD8		0
wing disc ML-DmD9		0
wing disc ML-DmD16-c3		15
wing disc ML-DmD21		1
wing disc ML-DmD32		0
haltere disc ML-DmD17-c3		0
eye-antennal disc ML-DmD11		0
antennal disc ML-DmD20-c5		0
mixed discs ML-DmD4-c1		0
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		0
tumorous blood cells mbn2		0
ovary fGS/OSS		0
ovary OSC		0
ovary OSS		0
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		0
Schneider line 2 Sg4		1
embryonic 1182-4H		0
embryonic GM2		70
embryonic Kc167		0
embryonic S1		3
embryonic S3		0
leg disc CME L1		1
wing disc CME-W2		1
wing disc ML-DmD8		0
wing disc ML-DmD9		0
wing disc ML-DmD16-c3		15
wing disc ML-DmD21		1
wing disc ML-DmD32		0
haltere disc ML-DmD17-c3		0
eye-antennal disc ML-DmD11		0
antennal disc ML-DmD20-c5		0
mixed discs ML-DmD4-c1		0
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		0
tumorous blood cells mbn2		0
ovary fGS/OSS		0
ovary OSC		0
ovary OSS		0
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		0
Schneider line 2 Sg4		1
embryonic 1182-4H		0
embryonic GM2		(70)
embryonic Kc167		0
embryonic S1		3
embryonic S3		0
leg disc CME L1		1
wing disc CME-W2		1
wing disc ML-DmD8		0
wing disc ML-DmD9		0
wing disc ML-DmD16-c3		15
wing disc ML-DmD21		1
wing disc ML-DmD32		0
haltere disc ML-DmD17-c3		0
eye-antennal disc ML-DmD11		0
antennal disc ML-DmD20-c5		0
mixed discs ML-DmD4-c1		0
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		0
tumorous blood cells mbn2		0
ovary fGS/OSS		0
ovary OSC		0
ovary OSS		0
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		0
Schneider line 2 Sg4		1
embryonic 1182-4H		0
embryonic GM2		70
embryonic Kc167		0
embryonic S1		3
embryonic S3		0
leg disc CME L1		1
wing disc CME-W2		1
wing disc ML-DmD8		0
wing disc ML-DmD9		0
wing disc ML-DmD16-c3		15
wing disc ML-DmD21		1
wing disc ML-DmD32		0
haltere disc ML-DmD17-c3		0
eye-antennal disc ML-DmD11		0
antennal disc ML-DmD20-c5		0
mixed discs ML-DmD4-c1		0
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		0
tumorous blood cells mbn2		0
ovary fGS/OSS		0
ovary OSC		0
ovary OSS		0
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		0
Schneider line 2 Sg4		1
embryonic 1182-4H		0
embryonic GM2		70
embryonic Kc167		0
embryonic S1		3
embryonic S3		0
leg disc CME L1		1
wing disc CME-W2		1
wing disc ML-DmD8		0
wing disc ML-DmD9		0
wing disc ML-DmD16-c3		15
wing disc ML-DmD21		1
wing disc ML-DmD32		0
haltere disc ML-DmD17-c3		0
eye-antennal disc ML-DmD11		0
antennal disc ML-DmD20-c5		0
mixed discs ML-DmD4-c1		0
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		0
tumorous blood cells mbn2		0
ovary fGS/OSS		0
ovary OSC		0
ovary OSS		0
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Cell Line		Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS

modENCODE Treatments RNA-Seq

modENCODE Treatment Expression Data

(modENCODE_mRNA-Seq_treatments)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		3
cold shock, 4-day adult		2
heat shock, 4-day adult		26
Cadmium 50 mM 6 hrs, larvae L3		48
Cadmium 50 mM 12 hrs, larvae L3		17
Cadmium 50 mM 48 hrs, 4-day adult		29
Cadmium 100 mM 48 hrs, 4-day adult		4
Copper 0.5 mM 12 hrs, larvae L3		19
Copper 15 mM 48 hrs, 4-day adult		4
Zinc 5 mM 12 hrs, larvae L3		18
Zinc 4.5 mM 48 hrs, 4-day adult		5
Ethanol 2.5% 3 hrs, larvae L3		4
Ethanol 5% 3 hrs, larvae L3		89
Ethanol 10% 3 hrs, larvae L3		59
Caffeine 1.5 mg/ml 4 hrs, larvae L3		52
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		3
Caffeine 25 mg/ml 48 hrs, 4-day adult		2
Paraquat 5 mM 48 hrs, 4-day adult		7
Paraquat 10 mM 48 hrs, 4-day adult		1
Rotenone 2 μg 12 hrs, larvae L3		92
Rotenone 8 μg 12 hrs, larvae L3		77
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		3
cold shock, 4-day adult		2
heat shock, 4-day adult		26
Cadmium 50 mM 6 hrs, larvae L3		(48)
Cadmium 50 mM 12 hrs, larvae L3		17
Cadmium 50 mM 48 hrs, 4-day adult		(29)
Cadmium 100 mM 48 hrs, 4-day adult		4
Copper 0.5 mM 12 hrs, larvae L3		19
Copper 15 mM 48 hrs, 4-day adult		4
Zinc 5 mM 12 hrs, larvae L3		18
Zinc 4.5 mM 48 hrs, 4-day adult		5
Ethanol 2.5% 3 hrs, larvae L3		4
Ethanol 5% 3 hrs, larvae L3		(89)
Ethanol 10% 3 hrs, larvae L3		(59)
Caffeine 1.5 mg/ml 4 hrs, larvae L3		(52)
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		3
Caffeine 25 mg/ml 48 hrs, 4-day adult		2
Paraquat 5 mM 48 hrs, 4-day adult		7
Paraquat 10 mM 48 hrs, 4-day adult		1
Rotenone 2 μg 12 hrs, larvae L3		(92)
Rotenone 8 μg 12 hrs, larvae L3		(77)
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		3
cold shock, 4-day adult		2
heat shock, 4-day adult		26
Cadmium 50 mM 6 hrs, larvae L3		48
Cadmium 50 mM 12 hrs, larvae L3		17
Cadmium 50 mM 48 hrs, 4-day adult		29
Cadmium 100 mM 48 hrs, 4-day adult		4
Copper 0.5 mM 12 hrs, larvae L3		19
Copper 15 mM 48 hrs, 4-day adult		4
Zinc 5 mM 12 hrs, larvae L3		18
Zinc 4.5 mM 48 hrs, 4-day adult		5
Ethanol 2.5% 3 hrs, larvae L3		4
Ethanol 5% 3 hrs, larvae L3		89
Ethanol 10% 3 hrs, larvae L3		59
Caffeine 1.5 mg/ml 4 hrs, larvae L3		52
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		3
Caffeine 25 mg/ml 48 hrs, 4-day adult		2
Paraquat 5 mM 48 hrs, 4-day adult		7
Paraquat 10 mM 48 hrs, 4-day adult		1
Rotenone 2 μg 12 hrs, larvae L3		92
Rotenone 8 μg 12 hrs, larvae L3		77
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		3
cold shock, 4-day adult		2
heat shock, 4-day adult		26
Cadmium 50 mM 6 hrs, larvae L3		48
Cadmium 50 mM 12 hrs, larvae L3		17
Cadmium 50 mM 48 hrs, 4-day adult		29
Cadmium 100 mM 48 hrs, 4-day adult		4
Copper 0.5 mM 12 hrs, larvae L3		19
Copper 15 mM 48 hrs, 4-day adult		4
Zinc 5 mM 12 hrs, larvae L3		18
Zinc 4.5 mM 48 hrs, 4-day adult		5
Ethanol 2.5% 3 hrs, larvae L3		4
Ethanol 5% 3 hrs, larvae L3		89
Ethanol 10% 3 hrs, larvae L3		59
Caffeine 1.5 mg/ml 4 hrs, larvae L3		52
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		3
Caffeine 25 mg/ml 48 hrs, 4-day adult		2
Paraquat 5 mM 48 hrs, 4-day adult		7
Paraquat 10 mM 48 hrs, 4-day adult		1
Rotenone 2 μg 12 hrs, larvae L3		92
Rotenone 8 μg 12 hrs, larvae L3		77
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		3
cold shock, 4-day adult		2
heat shock, 4-day adult		26
Cadmium 50 mM 6 hrs, larvae L3		48
Cadmium 50 mM 12 hrs, larvae L3		17
Cadmium 50 mM 48 hrs, 4-day adult		29
Cadmium 100 mM 48 hrs, 4-day adult		4
Copper 0.5 mM 12 hrs, larvae L3		19
Copper 15 mM 48 hrs, 4-day adult		4
Zinc 5 mM 12 hrs, larvae L3		18
Zinc 4.5 mM 48 hrs, 4-day adult		5
Ethanol 2.5% 3 hrs, larvae L3		4
Ethanol 5% 3 hrs, larvae L3		89
Ethanol 10% 3 hrs, larvae L3		59
Caffeine 1.5 mg/ml 4 hrs, larvae L3		52
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		3
Caffeine 25 mg/ml 48 hrs, 4-day adult		2
Paraquat 5 mM 48 hrs, 4-day adult		7
Paraquat 10 mM 48 hrs, 4-day adult		1
Rotenone 2 μg 12 hrs, larvae L3		92
Rotenone 8 μg 12 hrs, larvae L3		77
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		3
cold shock, 4-day adult		2
heat shock, 4-day adult		26
Cadmium 50 mM 6 hrs, larvae L3		(48)
Cadmium 50 mM 12 hrs, larvae L3		17
Cadmium 50 mM 48 hrs, 4-day adult		29
Cadmium 100 mM 48 hrs, 4-day adult		4
Copper 0.5 mM 12 hrs, larvae L3		19
Copper 15 mM 48 hrs, 4-day adult		4
Zinc 5 mM 12 hrs, larvae L3		18
Zinc 4.5 mM 48 hrs, 4-day adult		5
Ethanol 2.5% 3 hrs, larvae L3		4
Ethanol 5% 3 hrs, larvae L3		(89)
Ethanol 10% 3 hrs, larvae L3		(59)
Caffeine 1.5 mg/ml 4 hrs, larvae L3		(52)
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		3
Caffeine 25 mg/ml 48 hrs, 4-day adult		2
Paraquat 5 mM 48 hrs, 4-day adult		7
Paraquat 10 mM 48 hrs, 4-day adult		1
Rotenone 2 μg 12 hrs, larvae L3		(92)
Rotenone 8 μg 12 hrs, larvae L3		(77)
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		3
cold shock, 4-day adult		2
heat shock, 4-day adult		26
Cadmium 50 mM 6 hrs, larvae L3		48
Cadmium 50 mM 12 hrs, larvae L3		17
Cadmium 50 mM 48 hrs, 4-day adult		29
Cadmium 100 mM 48 hrs, 4-day adult		4
Copper 0.5 mM 12 hrs, larvae L3		19
Copper 15 mM 48 hrs, 4-day adult		4
Zinc 5 mM 12 hrs, larvae L3		18
Zinc 4.5 mM 48 hrs, 4-day adult		5
Ethanol 2.5% 3 hrs, larvae L3		4
Ethanol 5% 3 hrs, larvae L3		89
Ethanol 10% 3 hrs, larvae L3		59
Caffeine 1.5 mg/ml 4 hrs, larvae L3		52
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		3
Caffeine 25 mg/ml 48 hrs, 4-day adult		2
Paraquat 5 mM 48 hrs, 4-day adult		7
Paraquat 10 mM 48 hrs, 4-day adult		1
Rotenone 2 μg 12 hrs, larvae L3		92
Rotenone 8 μg 12 hrs, larvae L3		77
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		3
cold shock, 4-day adult		2
heat shock, 4-day adult		26
Cadmium 50 mM 6 hrs, larvae L3		48
Cadmium 50 mM 12 hrs, larvae L3		17
Cadmium 50 mM 48 hrs, 4-day adult		29
Cadmium 100 mM 48 hrs, 4-day adult		4
Copper 0.5 mM 12 hrs, larvae L3		19
Copper 15 mM 48 hrs, 4-day adult		4
Zinc 5 mM 12 hrs, larvae L3		18
Zinc 4.5 mM 48 hrs, 4-day adult		5
Ethanol 2.5% 3 hrs, larvae L3		4
Ethanol 5% 3 hrs, larvae L3		89
Ethanol 10% 3 hrs, larvae L3		59
Caffeine 1.5 mg/ml 4 hrs, larvae L3		52
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		3
Caffeine 25 mg/ml 48 hrs, 4-day adult		2
Paraquat 5 mM 48 hrs, 4-day adult		7
Paraquat 10 mM 48 hrs, 4-day adult		1
Rotenone 2 μg 12 hrs, larvae L3		92
Rotenone 8 μg 12 hrs, larvae L3		77
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Treatment		Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3

Expression Clusters

A cluster of genes with similar mRNA expression dynamics across development.

(The modENCODE Consortium, 2010, Graveley et al., 2011)

External Data & Images

Linkouts

BDGP expression data

•

RE61589

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0039051

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG17109-RA

FlyExpress - Embryonic expression images (BDGP data)

•

Show all FlyExpress processed images for CG17109

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

partially lethal - majority die | pupal stage, with Scer\GAL4^pnr-MD237

CG17109^GD9285

viable, with Scer\GAL4^pnr-MD237

CG17109^GD16624

Phenotype manifest in

Allele

Classical Alleles ( 1 )

For All Classical Alleles Show

Allele of CG17109	Class	Mutagen	Stocks	Known lesion
CG17109^MB08905			1	--

Alleles Carried on Transgenic Constructs ( 3 )

For All Alleles Carried on Transgenic Constructs Show

Allele of CG17109	Mutagen	Stocks	Known lesion
CG17109^GD16624	in vitro construct - RNAi in vitro construct - regulatory fusion	2	Yes
CG17109^GD9285	in vitro construct - RNAi in vitro construct - regulatory fusion	2	Yes
CG17109^NIG.17109R	in vitro construct - RNAi in vitro construct - regulatory fusion	0	Yes

Aneuploid Aberrations

Disrupted in

Df(3R)Exel6193

(Ryder, 2004.4.26)

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD9285}

P{GD16624}

P{NIG.17109R}

Insertions

Type of insertions

Name

Expression data

insertion of enhancer trap binary system

Mi{ET1}CG13830^MB08905

Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )

Terms Based on Experimental Evidence ( 0 terms )

Terms Based on Predictions or Assertions ( 3 terms )

Molecular Function

CV term

Evidence

References

NOT
aminoacylase activity

non-traceable author statement

(FlyBase, 1992-)

aminoacylase activity

inferred from electronic annotation with InterPro:IPR010159

(FlyBase Curators et al., 2004-)

Biological Process

CV term

Evidence

References

cellular amino acid metabolic process

inferred from electronic annotation with InterPro:IPR010159

(FlyBase Curators et al., 2004-)

Cellular Component

CV term

Evidence

References

cytoplasm

inferred from electronic annotation with InterPro:IPR010159

(FlyBase Curators et al., 2004-)

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Interactions & Pathways

Summary of Physical Interactions

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

CG17109 allele

Gene

References

External Data

Linkouts

BioGRID - A database of protein and genetic interactions

•

67675

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0039051

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

42730

Orthologs

OrthoDB Orthologs (61) - based on analysis using Dmel annotation version 5.41

OrthoDB Ortholog Groups

OrthoDB orthology group searches

(Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288)

Drosophila inclusive ortholog search

EOG6RJGMD

Dipteran inclusive ortholog search

EOG634WFK

Insect inclusive ortholog search

EOG6SF82B

Arthropod inclusive ortholog search

EOG68CZ9S

Metazoa inclusive ortholog search

EOG66MQC3

Orthologs in Drosophila Species (EOG6RJGMD)

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Dmel\CG17109

Drosophila melanogaster

fruit fly

Dmel\CG6733

Drosophila melanogaster

fruit fly

Drosophila simulans

Drosophila simulans

Drosophila simulans

Drosophila sechellia

Drosophila sechellia

Drosophila erecta

Drosophila erecta

Drosophila yakuba

Drosophila yakuba

Drosophila yakuba

Drosophila ananassae

Drosophila ananassae

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA19818

Drosophila persimilis

Dper\GL13664

Drosophila willistoni

Dwil\GK14413

Orthologs in non-Drosophila Dipterans (EOG634WFK)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL011206

Anopheles gambiae

Malaria mosquito

Agam\AGAP000679

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ013669

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ013670

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ009804

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ013671

Orthologs in non-Dipteran Insects (EOG6SF82B)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Apis mellifera

Western honey bee

Amel\LOC408969

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG014144

Acromyrmex echinatior

Panamanian leafcutter ant

Aech\AECH12440

Atta cephalotes

Leafcutter ant

Acep\ACEP14422

Camponotus floridanus

Florida carpenter ant

Cflo\CFLO23461

Camponotus floridanus

Florida carpenter ant

Cflo\CFLO23227

Harpegnathos saltator

Jerdons jumping ant

Hsal\HSAL18649

Harpegnathos saltator

Jerdons jumping ant

Hsal\HSAL18648

Harpegnathos saltator

Jerdons jumping ant

Hsal\HSAL15518

Linepithema humile

Argentine ant

Lhum\LH15213

Pogonomyrmex barbatus

Red harvester ant

Pbar\PB20516

Solenopsis invicta

Red fire ant

Sinv\SINV24105

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI003420

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI006254

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI009740

Bombyx mori

Silkmoth

Bmor\BGIBMGA010352

Pediculus humanus

Human body louse

Phum\PHUM047660

Tribolium castaneum

Red flour beetle

Tcas\TC012531

Tribolium castaneum

Red flour beetle

Tcas\TC012530

Tribolium castaneum

Red flour beetle

Tcas\TC012529

Orthologs in non-Insect Arthropods (EOG68CZ9S)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Daphnia pulex

Water flea

Dpux\Hrb87F

Daphnia pulex

Water flea

Dpux\JGI_V11_48442

Ixodes scapularis

Deer tick

Isca\ISCW020050

Orthologs in non-Arthropod Metazoa (EOG66MQC3)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Caenorhabditis elegans

Nematode

Cele\C10C5.5

Caenorhabditis elegans

Nematode

Cele\C10C5.3

Caenorhabditis elegans

Nematode

Cele\C10C5.4

Caenorhabditis elegans

Nematode

Cele\C06A6.4

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_010120gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_015090gn

Danio rerio

Zebrafish

Drer\CU896698.1

Danio rerio

Zebrafish

Drer\ENSDARG00000038475

Xenopus tropicalis

Western clawed frog

Xtro\acy1.1

Xenopus tropicalis

Western clawed frog

Xtro\ENSXETG00000032120

Mus musculus

House mouse

Mmus\ENSMUSG00000023262

Rattus norvegicus

Norway rat

Rnor\Acy1a

Homo sapiens

Human

Hsap\ACY1

Human Orthologs (1)

Gene

OMIM

HGNC

Hsap\ACY1

AAA Orthologs (3) based on analysis using Dmel annotation version 4.3

Organism

Gene

Drosophila sechellia

Dsec\GM26486

Drosophila erecta

Dere\GG11186

Drosophila yakuba

Dyak\GE10353

Stocks & Reagents

Stocks Listed in FlyBase ( 5 )

Bloomington

26415

w¹¹¹⁸; Mi{ET1}CG13830^MB08905 CG17109^MB08905

VDRC

v32858

w¹¹¹⁸ P{GD9285}v32858

v50820

w¹¹¹⁸ P{GD16624}v50820

v32859

w¹¹¹⁸; P{GD9285}v32859/TM3

v50819

w¹¹¹⁸; P{GD16624}v50819/TM3

Genomic Clones ( 1 )

BACR17P04

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones ( 5 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

RE61589

Other clones

FI09240

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RE63537

Other clones

RNAi & Array Information

Linkouts

DRSC - Results from RNAi screens.

•

FBgn0039051

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

42730

Antibody Information

Other Information

Discoverer

Etymology

Identification

Relationship to Other Genes

Source for database identity of

Source for database merge of

Additional comments

Other Comments

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

RefSeq (Proteins)

•

DDBJ / EMBL / GenBank

•

Entrez Gene - A searchable database of RefSeq genes.

•

42730

UniProtKB/TrEMBL

•

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Peptidase M20 (IPR002933)

N-acyl-L-amino-acid amidohydrolase (IPR010159)

Peptidase M20, dimerisation domain (IPR011650)

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

•

RE61589

Linkouts

BioGRID - A database of protein and genetic interactions

•

67675

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0039051

DRSC - Results from RNAi screens.

•

FBgn0039051

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0039051

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG17109-RA

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0039051

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

42730

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

42730

modMine - Data generated by the modENCODE project.

•

FBgn0039051

Synonyms & Secondary IDs ( 1 )

Reported As

Symbol Synonym

CG17109

(Conant and Wagner, 2003, Japanese National Institute of Genetics, 2012.5.21)

Name Synonym

Secondary FlyBase IDs

References ( 19 )

Research paper

Antosh et al., 2011, Aging 3(6): 576--583: New comparative genomics approach reveals a conserved health span signature across species. [FBrf0216594]
Asha et al., 2003, Genetics 163(1): 203--215: Analysis of ras-induced overproliferation in Drosophila hemocytes. [FBrf0155813]
Conant and Wagner, 2003, Genome Res. 13(9): 2052--2058: Asymmetric sequence divergence of duplicate genes. [FBrf0167689]
de Morais Guedes et al., 2003, Biochem. Biophys. Res. Commun. 312(3): 545--554: Drosophila melanogaster larval hemolymph protein mapping. [FBrf0167337]
Vierstraete et al., 2003, Biochem. Biophys. Res. Commun. 304(4): 831--838: Proteomics in Drosophila melanogaster: first 2D database of larval hemolymph proteins. [FBrf0158736]

Supplementary material

Graveley et al., 2011, Nature 471(7339):: Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980]
The modENCODE Consortium, 2010, Science 330(6012):: DataS14: Gene co-expression clusters. [FBrf0213979]
Mummery-Widmer et al., 2009, Nature 458(7241):: Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Giot et al., 2003, Science 302(5651):: Tables S1 to S7. [FBrf0166452]

Personal communication to FlyBase

Bellen, 2008.12.12, set821.xml: set821.xml [FBrf0206287]
Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center: RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327]
FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms.: Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
Ryder, 2004.4.26, Exelixis CG deletion data.: Exelixis CG deletion data. [FBrf0184335]
BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file): Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]

FlyBase analysis

FlyBase, 1992-, FlyBase curation.: FlyBase curation. [FBrf0105495]

Stock list

Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY.: RNAi stocks available from NIG-FLY. [FBrf0218457]

Website

Fisher et al., 2012, BDGP insitu homepage: BDGP insitu homepage [FBrf0219073]

Curated genome annotation

Gong, 1999.11, [Annotations performed at the Celera Jamboreee.]: [Annotations performed at the Celera Jamboreee.] [FBrf0126669]