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Gene Dmel\CG6733

General Information
Symbol	Dmel\CG6733	Species	D. melanogaster
Name		Annotation symbol	CG6733
Feature type	protein_coding_gene	FlyBase ID	FBgn0039052
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	94D13-94D13	Sequence location	3R:18,923,440..18,924,913 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG6733 (FBgn0039052). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: aminoacylase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: cellular amino acid metabolic process. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: N-acyl-L-amino-acid amidohydrolase; Peptidase M20; Peptidase M20, dimerisation. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression. Peak expression observed within 06-18 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval/adult Malpighian tubules. Expression at moderate levels in the following post-embryonic organs or tissues: adult hindgut, adult heart. Comments on Affy2 ProbeSet: ProbeSet 1632228_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG6733. Gene sequence location is 3R:18923440..18924913.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features BKN45017 BKN32403 HFA16103
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 94D13-94D13   Limits computationally determined from genome sequence between P{lacW}GclmL0580 and P{EP}hhEP3521
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG6733 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG6733-RA FBtr0084352  NM_142866   1301   401
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG6733-PA   FBpp0083745   44.9   401   5.84     NP_651123   AAF56097
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Peptidase M20 (IPR002933) N-acyl-L-amino-acid amidohydrolase (IPR010159) Peptidase M20, dimerisation (IPR011650)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF56097   BI214539   BI242182   BI375279   BT023493   EC051220   EC053713   EC054745   EC055309   EV588561   FD585688   FD586054   FD586680   FD586716   FD587339   FD587386   FD587401   FD587428   GH738836   GH742990   GH743921   GH763976   GH765915   GH766323
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VCQ9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0039052    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0039052 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression. Peak expression observed within 06-18 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0039052 expression level Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    29 embryo 04-06hr    39 embryo 06-08hr    386 embryo 08-10hr    1167 embryo 10-12hr    4038 embryo 12-14hr    4075 embryo 14-16hr    2262 embryo 16-18hr    2195 embryo 18-20hr    856 embryo 20-22hr    1892 embryo 22-24hr    1311 larva L1    1447 larva L2    758 larva L3 12hr old    1232 larva L3 puffstage 1-2    1270 larva L3 puffstage 3-6    530 larva L3 puffstage 7-9    181 white prepupae new    66 white prepupae 12hr    509 white prepupae 24hr    490 pupae 2d postWPP    517 pupae 3d postWPP    111 pupae 4d postWPP    564 adult male 01day    2650 adult male 05day    2387 adult male 30day    2651 adult female 01day    1729 adult female 05day    888 adult female 30day    1565 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    29 embryo 04-06hr    39 embryo 06-08hr  (386) embryo 08-10hr  (1167) embryo 10-12hr  (4038) embryo 12-14hr  (4075) embryo 14-16hr  (2262) embryo 16-18hr  (2195) embryo 18-20hr  (856) embryo 20-22hr  (1892) embryo 22-24hr  (1311) larva L1  (1447) larva L2  (758) larva L3 12hr old  (1232) larva L3 puffstage 1-2  (1270) larva L3 puffstage 3-6  (530) larva L3 puffstage 7-9  (181) white prepupae new    66 white prepupae 12hr  (509) white prepupae 24hr  (490) pupae 2d postWPP  (517) pupae 3d postWPP  (111) pupae 4d postWPP  (564) adult male 01day  (2650) adult male 05day  (2387) adult male 30day  (2651) adult female 01day  (1729) adult female 05day  (888) adult female 30day  (1565) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    29 embryo 04-06hr    39 embryo 06-08hr    386 embryo 08-10hr    1167 embryo 10-12hr  (4038) embryo 12-14hr  (4075) embryo 14-16hr  (2262) embryo 16-18hr  (2195) embryo 18-20hr    856 embryo 20-22hr  (1892) embryo 22-24hr    1311 larva L1  1447 larva L2    758 larva L3 12hr old    1232 larva L3 puffstage 1-2    1270 larva L3 puffstage 3-6    530 larva L3 puffstage 7-9    181 white prepupae new    66 white prepupae 12hr    509 white prepupae 24hr    490 pupae 2d postWPP    517 pupae 3d postWPP    111 pupae 4d postWPP    564 adult male 01day  (2650) adult male 05day  (2387) adult male 30day  (2651) adult female 01day  (1729) adult female 05day    888 adult female 30day  (1565) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    29 embryo 04-06hr    39 embryo 06-08hr    386 embryo 08-10hr    1167 embryo 10-12hr    4038 embryo 12-14hr    4075 embryo 14-16hr    2262 embryo 16-18hr    2195 embryo 18-20hr    856 embryo 20-22hr    1892 embryo 22-24hr    1311 larva L1    1447 larva L2    758 larva L3 12hr old    1232 larva L3 puffstage 1-2    1270 larva L3 puffstage 3-6    530 larva L3 puffstage 7-9    181 white prepupae new    66 white prepupae 12hr    509 white prepupae 24hr    490 pupae 2d postWPP    517 pupae 3d postWPP    111 pupae 4d postWPP    564 adult male 01day    2650 adult male 05day    2387 adult male 30day    2651 adult female 01day    1729 adult female 05day    888 adult female 30day    1565 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    29 embryo 04-06hr    39 embryo 06-08hr    386 embryo 08-10hr    1167 embryo 10-12hr    4038 embryo 12-14hr    4075 embryo 14-16hr    2262 embryo 16-18hr    2195 embryo 18-20hr    856 embryo 20-22hr    1892 embryo 22-24hr    1311 larva L1    1447 larva L2    758 larva L3 12hr old    1232 larva L3 puffstage 1-2    1270 larva L3 puffstage 3-6    530 larva L3 puffstage 7-9    181 white prepupae new    66 white prepupae 12hr    509 white prepupae 24hr    490 pupae 2d postWPP    517 pupae 3d postWPP    111 pupae 4d postWPP    564 adult male 01day    2650 adult male 05day    2387 adult male 30day    2651 adult female 01day    1729 adult female 05day    888 adult female 30day    1565 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0039052 expression level Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    29 embryo 04-06hr    39 embryo 06-08hr    386 embryo 08-10hr    1167 embryo 10-12hr    4038 embryo 12-14hr    4075 embryo 14-16hr    2262 embryo 16-18hr    2195 embryo 18-20hr    856 embryo 20-22hr    1892 embryo 22-24hr    1311 larva L1    1447 larva L2    758 larva L3 12hr old    1232 larva L3 puffstage 1-2    1270 larva L3 puffstage 3-6    530 larva L3 puffstage 7-9    181 white prepupae new    66 white prepupae 12hr    509 white prepupae 24hr    490 pupae 2d postWPP    517 pupae 3d postWPP    111 pupae 4d postWPP    564 adult male 01day    2650 adult male 05day    2387 adult male 30day    2651 adult female 01day    1729 adult female 05day    888 adult female 30day    1565 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    29 embryo 04-06hr    39 embryo 06-08hr  (386) embryo 08-10hr  (1167) embryo 10-12hr  (4038) embryo 12-14hr  (4075) embryo 14-16hr  (2262) embryo 16-18hr  (2195) embryo 18-20hr  (856) embryo 20-22hr  (1892) embryo 22-24hr  (1311) larva L1  (1447) larva L2  (758) larva L3 12hr old  (1232) larva L3 puffstage 1-2  (1270) larva L3 puffstage 3-6  (530) larva L3 puffstage 7-9  (181) white prepupae new    66 white prepupae 12hr  (509) white prepupae 24hr  (490) pupae 2d postWPP  (517) pupae 3d postWPP  111 pupae 4d postWPP  (564) adult male 01day  (2650) adult male 05day  (2387) adult male 30day  (2651) adult female 01day  (1729) adult female 05day  (888) adult female 30day  (1565) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    29 embryo 04-06hr    39 embryo 06-08hr    386 embryo 08-10hr    1167 embryo 10-12hr  (4038) embryo 12-14hr  (4075) embryo 14-16hr  2262 embryo 16-18hr  2195 embryo 18-20hr    856 embryo 20-22hr  1892 embryo 22-24hr    1311 larva L1  1447 larva L2    758 larva L3 12hr old    1232 larva L3 puffstage 1-2    1270 larva L3 puffstage 3-6    530 larva L3 puffstage 7-9    181 white prepupae new    66 white prepupae 12hr    509 white prepupae 24hr    490 pupae 2d postWPP    517 pupae 3d postWPP    111 pupae 4d postWPP    564 adult male 01day  (2650) adult male 05day  2387 adult male 30day  (2651) adult female 01day  1729 adult female 05day    888 adult female 30day  1565 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    29 embryo 04-06hr    39 embryo 06-08hr    386 embryo 08-10hr    1167 embryo 10-12hr    4038 embryo 12-14hr    4075 embryo 14-16hr    2262 embryo 16-18hr    2195 embryo 18-20hr    856 embryo 20-22hr    1892 embryo 22-24hr    1311 larva L1    1447 larva L2    758 larva L3 12hr old    1232 larva L3 puffstage 1-2    1270 larva L3 puffstage 3-6    530 larva L3 puffstage 7-9    181 white prepupae new    66 white prepupae 12hr    509 white prepupae 24hr    490 pupae 2d postWPP    517 pupae 3d postWPP    111 pupae 4d postWPP    564 adult male 01day    2650 adult male 05day    2387 adult male 30day    2651 adult female 01day    1729 adult female 05day    888 adult female 30day    1565 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    29 embryo 04-06hr    39 embryo 06-08hr    386 embryo 08-10hr    1167 embryo 10-12hr    4038 embryo 12-14hr    4075 embryo 14-16hr    2262 embryo 16-18hr    2195 embryo 18-20hr    856 embryo 20-22hr    1892 embryo 22-24hr    1311 larva L1    1447 larva L2    758 larva L3 12hr old    1232 larva L3 puffstage 1-2    1270 larva L3 puffstage 3-6    530 larva L3 puffstage 7-9    181 white prepupae new    66 white prepupae 12hr    509 white prepupae 24hr    490 pupae 2d postWPP    517 pupae 3d postWPP    111 pupae 4d postWPP    564 adult male 01day    2650 adult male 05day    2387 adult male 30day    2651 adult female 01day    1729 adult female 05day    888 adult female 30day    1565 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0039052    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0039052 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval/adult Malpighian tubules. Expression at moderate levels in the following post-embryonic organs or tissues: adult hindgut, adult heart. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0039052 expression level Tissue   Expression Level Larval Central Nervous System    3.5 Larval Midgut    8.3 Larval Hindgut no informative data Larval Malpighian Tubules    1624.2 Larval Fat Body    3.2 Larval Salivary Gland    5 Larval Trachea    5.675 Larval Carcass    9.15 Adult Head    36.8 Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    251.6 Adult Malpighian Tubules    4798 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    156.275 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    2.3 Adult Testis    3.8 Adult Male Accessory Gland    5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    3.5 Larval Midgut    8.3 Larval Hindgut no informative data Larval Malpighian Tubules  (1624.2) Larval Fat Body    3.2 Larval Salivary Gland    5 Larval Trachea    5.675 Larval Carcass    9.15 Adult Head    36.8 Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    251.6 Adult Malpighian Tubules  (4798) Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    156.275 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    2.3 Adult Testis    3.8 Adult Male Accessory Gland    5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    3.5 Larval Midgut    8.3 Larval Hindgut no informative data Larval Malpighian Tubules  (1624.2) Larval Fat Body    3.2 Larval Salivary Gland    5 Larval Trachea    5.675 Larval Carcass    9.15 Adult Head    36.8 Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    251.6 Adult Malpighian Tubules  (4798) Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    156.275 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    2.3 Adult Testis    3.8 Adult Male Accessory Gland    5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    3.5 Larval Midgut    8.3 Larval Hindgut no informative data Larval Malpighian Tubules    1624.2 Larval Fat Body    3.2 Larval Salivary Gland    5 Larval Trachea    5.675 Larval Carcass    9.15 Adult Head    36.8 Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    251.6 Adult Malpighian Tubules    4798 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    156.275 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    2.3 Adult Testis    3.8 Adult Male Accessory Gland    5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0039052 expression level Tissue   Expression Level Larval Central Nervous System    3.5 Larval Midgut    8.3 Larval Hindgut no informative data Larval Malpighian Tubules    1624.2 Larval Fat Body    3.2 Larval Salivary Gland    5 Larval Trachea    5.675 Larval Carcass    9.15 Adult Head    36.8 Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    251.6 Adult Malpighian Tubules    4798 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    156.275 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    2.3 Adult Testis    3.8 Adult Male Accessory Gland    5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    3.5 Larval Midgut    8.3 Larval Hindgut no informative data Larval Malpighian Tubules  (1624.2) Larval Fat Body    3.2 Larval Salivary Gland    5 Larval Trachea    5.675 Larval Carcass    9.15 Adult Head    36.8 Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    251.6 Adult Malpighian Tubules  (4798) Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    156.275 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    2.3 Adult Testis    3.8 Adult Male Accessory Gland    5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    3.5 Larval Midgut    8.3 Larval Hindgut no informative data Larval Malpighian Tubules  1624.2 Larval Fat Body    3.2 Larval Salivary Gland    5 Larval Trachea    5.675 Larval Carcass    9.15 Adult Head    36.8 Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    251.6 Adult Malpighian Tubules  (4798) Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    156.275 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    2.3 Adult Testis    3.8 Adult Male Accessory Gland    5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    3.5 Larval Midgut    8.3 Larval Hindgut no informative data Larval Malpighian Tubules    1624.2 Larval Fat Body    3.2 Larval Salivary Gland    5 Larval Trachea    5.675 Larval Carcass    9.15 Adult Head    36.8 Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    251.6 Adult Malpighian Tubules    4798 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    156.275 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    2.3 Adult Testis    3.8 Adult Male Accessory Gland    5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut no informative data Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    36.8   NA  Eye    no informative data   NA  Brain    no informative data   3.5  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    no informative data   NA  Crop    no informative data   8.3  Midgut    no informative data   no informative data  Hindgut    251.6   1624.2  Malpighian Tubules    4798   3.2  Fat Body    no informative data   5  Salivary Gland    no informative data   NA  Heart    156.275   5.675  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    2.3   NA  Testis    3.8   NA  Male Accessory Gland    5   9.15  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_09
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039052 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6733-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG6733GD16561 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of CG6733 Class Mutagen Stocks Known lesion CG6733MB09645 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG6733 Class Mutagen Stocks Known lesion CG6733GD16561 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG6733KK112403 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG6733GD12019 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6193 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD12019} NA P{GD16561} NA P{KK112403} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system Mi{ET1}CG13830MB09645 No
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
NOT aminoacylase activity non-traceable author statement (FlyBase, 1992-) aminoacylase activity inferred from electronic annotation with InterPro:IPR010159 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
cellular amino acid metabolic process inferred from electronic annotation with InterPro:IPR010159 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
cytoplasm inferred from electronic annotation with InterPro:IPR010159 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG6733 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67676 DroID - A comprehensive database of gene and protein interactions. • FBgn0039052 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42731
Orthologs
Genome-wide drosophilid orthologs	Dsec\GM26487
Curated drosophilid orthologs	Dpse\GA19818
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • CE03011 Caenorhabditis elegans (worm) CE20491 Caenorhabditis elegans (worm) cn07316 Cryptococcus neoformans (yeast-like fungus) cn08271 Cryptococcus neoformans (yeast-like fungus) Tc00.1047053507657.10 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053507657.20 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053507689.30 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053507689.40 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053510837.20 Trypanosoma cruzi (parasitic trypanosome) YALI0D17446g Yarrowia lipolytica (nonconventional yeast) YALI0F16489g Yarrowia lipolytica (nonconventional yeast) YALI0F25333g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0228221 FBgn0216419 FBgn0192455 FBgn0181340 FBgn0079814 FBgn0151269 FBgn0103488 FBgn0093997
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	29056 w1118; Mi{ET1}CG13830MB09645 CG6733MB09645
VDRC	v102774 P{KK112403}VIE-260B v50173 w1118; P{GD16561}v50173 v50172 w1118; P{GD16561}v50172/CyO
Genomic Clones ( 1 )
	BACR17P04 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 22 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE20374
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE39452 RE63051
Other clones	Dmel_neb_015179_0135_1446 EC051220 EC053713 EC054745 EC055309 RM03472 RM03572 RM03672 RM03772 RM03872 RM03972 RM04072 RM04172 RP01480 RP001009944 RP001018761 RP001033626 RP001041594 RP001050366
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0039052 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42731
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_142866 RefSeq (Proteins) • NP_651123 DDBJ / EMBL / GenBank • AAF56097 BI214539 Entrez Gene - A searchable database of RefSeq genes. • 42731 UniProtKB/TrEMBL • Q9VCQ9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Peptidase M20 (IPR002933) N-acyl-L-amino-acid amidohydrolase (IPR010159) Peptidase M20, dimerisation (IPR011650)
Linkouts
	BioGRID - A database of protein and genetic interactions • 67676 DroID - A comprehensive database of gene and protein interactions. • FBgn0039052 DRSC - Results from RNAi screens. • FBgn0039052 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039052 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6733-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0039052 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42731 InParanoid A subset of ortholog calls from InParanoid. • CE03011 Caenorhabditis elegans (worm) CE20491 Caenorhabditis elegans (worm) cn07316 Cryptococcus neoformans (yeast-like fungus) cn08271 Cryptococcus neoformans (yeast-like fungus) Tc00.1047053507657.10 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053507657.20 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053507689.30 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053507689.40 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053510837.20 Trypanosoma cruzi (parasitic trypanosome) YALI0D17446g Yarrowia lipolytica (nonconventional yeast) YALI0F16489g Yarrowia lipolytica (nonconventional yeast) YALI0F25333g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42731 modMine - Data generated by the modENCODE project. • FBgn0039052 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0228221 FBgn0216419 FBgn0192455 FBgn0181340 FBgn0079814 FBgn0151269 FBgn0103488 FBgn0093997
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG6733 (Conant and Wagner, 2003, Roxstrom-Lindquist et al., 2004, Keleman et al., 2009.8.5)
Name Synonym
Secondary FlyBase IDs
References ( 15 )
Research paper	Roxstrom-Lindquist et al., 2004, EMBO Rpts 5(2): 207--212 Parasite-specific immune response in adult Drosophila melanogaster: a genomic study. [FBrf0167559] Conant and Wagner, 2003, Genome Res. 13(9): 2052--2058 Asymmetric sequence divergence of duplicate genes. [FBrf0167689]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Dietzl et al., 2007, Nature 448(7150): Supplementary Table 1. [FBrf0202579] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Bellen, 2009.10.19, BDGP_2009_1020.GDP.xml BDGP_2009_1020.GDP.xml [FBrf0208884] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Curated genome annotation	Gong, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126669]