• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • CytoSearch
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Downloads:
  • Precomputed files
  • Archived data
  • Releases (FTP)
  • Genomes (FTP)
  • AAA data (FTP)
  • Lists:
  • Transposons (Dmel)
  • Transposons (other)
  • Vectors & Constructs
  • Anatomical Terms
  • Map Conversion
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Other links:
  • BDGP
  • DGRC
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\Ir

General Information
Symbol	Dmel\Ir	Species	D. melanogaster
Name	Inwardly rectifying potassium channel	Annotation symbol	CG6747
Feature type	protein_coding_gene	FlyBase ID	FBgn0039061
Gene Model Status	Current	Stock availability	6 publicly available
Also Known As	Dir, irk1
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	94E4-94E4	Sequence location	3R:18,999,595..19,011,364 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Inwardly rectifying potassium channel is referred to in FlyBase by the symbol Dmel\Ir (CG6747, FBgn0039061). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: inward rectifier potassium channel activity. There is experimental evidence that it is involved in the biological process: potassium ion transport; regulation of membrane potential. 6 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; mesothoracic tergum. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Immunoglobulin E-set; Potassium channel, inwardly rectifying, Kir; Potassium channel, inwardly rectifying, Kir, conserved region 2; Potassium channel, inwardly rectifying, Kir, cytoplasmic; Potassium channel, inwardly rectifying, Kir-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed during late larval stages, during early pupal stages, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval/adult midgut, larval/adult Malpighian tubules, larval/adult salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult crop, larval hindgut, larval trachea, adult ovary, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1627795_at completely aligns to an exonic region common to each of the 4 FlyBase-annotated transcript isoforms of Ir. Gene sequence location is 3R:18999595..19011364.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features HFA16106 BKN22315
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 94E4-94E4   Limits computationally determined from genome sequence between P{EP}hhEP3521 and P{PZ}cnc03921
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Ir for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Ir-RB FBtr0113273  NM_001104414   2813   555 Ir-RC FBtr0300388  NM_001170226   2213   526 Ir-RD FBtr0301382  NM_142874   2202   532 Ir-RE FBtr0303041  NM_001202341   3202   540
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Ir-PB   FBpp0112185   61.8   555   9.15     NP_001097884   ABW08737 Ir-PC   FBpp0289617   58.3   526   8.91     NP_001163697   ACZ94992 Ir-PD   FBpp0290596   59.1   532   9.15     NP_651131   AAF56107 Ir-PE   FBpp0292160   60.0   540   8.78     NP_001189270   ADV37361
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Potassium channel, inwardly rectifying, Kir-like (IPR001838) Potassium channel, inwardly rectifying, Kir, conserved region 2 (IPR013521) Potassium channel, inwardly rectifying, Kir, cytoplasmic (IPR013518) Immunoglobulin E-set (IPR014756) Potassium channel, inwardly rectifying, Kir (IPR016449)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF56107   AE014297 ABW08737   AE014297 ACZ94992   AE014297 ADV37361   AJ344344 CAC87637   AY044166 AAK98804   BG637372   BI634604   BT029920   BT029951   BT099989   CA804486   CA804888   CA806787   CA806839   CO280010   CO307182   CO308856   EC077721   EC088870   EC221227   EC222175   EC261970   EL870757   EL870827   EL870828   EL870985   EL870986   EL886054   EL886055   EL886271   EL886272
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q95UP7 Q9VCQ0 A8JR87 E1JIU2
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 17   organism | ubiquitous   (MacLean et al., 2002) embryonic stage 12 -- 17   presumptive embryonic salivary gland   (MacLean et al., 2002) third instar larval stage   embryonic/larval corpus cardiacum   (Kim and Rulifson, 2004) embryonic/larval brain   (MacLean et al., 2002) ventral nerve cord   (MacLean et al., 2002) wing disc   (MacLean et al., 2002) ventral thoracic disc   (MacLean et al., 2002) eye-antennal disc   (MacLean et al., 2002)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0039061    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0039061 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed during late larval stages, during early pupal stages, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0039061 expression level Developmental Stage   Expression Level embryo 00-02hr    1221 embryo 02-04hr    143 embryo 04-06hr    19 embryo 06-08hr    66 embryo 08-10hr    138 embryo 10-12hr    401 embryo 12-14hr    362 embryo 14-16hr    401 embryo 16-18hr    469 embryo 18-20hr    524 embryo 20-22hr    988 embryo 22-24hr    978 larva L1    975 larva L2    1024 larva L3 12hr old    1028 larva L3 puffstage 1-2    1174 larva L3 puffstage 3-6    1311 larva L3 puffstage 7-9    1634 white prepupae new    2492 white prepupae 12hr    2430 white prepupae 24hr    1297 pupae 2d postWPP    918 pupae 3d postWPP    646 pupae 4d postWPP    1237 adult male 01day    1449 adult male 05day    1281 adult male 30day    1517 adult female 01day    1812 adult female 05day    1396 adult female 30day    1371 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1221) embryo 02-04hr  (143) embryo 04-06hr    19 embryo 06-08hr    66 embryo 08-10hr  (138) embryo 10-12hr  (401) embryo 12-14hr  (362) embryo 14-16hr  (401) embryo 16-18hr  (469) embryo 18-20hr  (524) embryo 20-22hr  (988) embryo 22-24hr  (978) larva L1  (975) larva L2  (1024) larva L3 12hr old  (1028) larva L3 puffstage 1-2  (1174) larva L3 puffstage 3-6  (1311) larva L3 puffstage 7-9  (1634) white prepupae new  (2492) white prepupae 12hr  (2430) white prepupae 24hr  (1297) pupae 2d postWPP  (918) pupae 3d postWPP  (646) pupae 4d postWPP  (1237) adult male 01day  (1449) adult male 05day  (1281) adult male 30day  (1517) adult female 01day  (1812) adult female 05day  (1396) adult female 30day  (1371) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1221 embryo 02-04hr    143 embryo 04-06hr    19 embryo 06-08hr    66 embryo 08-10hr    138 embryo 10-12hr    401 embryo 12-14hr    362 embryo 14-16hr    401 embryo 16-18hr    469 embryo 18-20hr    524 embryo 20-22hr    988 embryo 22-24hr    978 larva L1    975 larva L2    1024 larva L3 12hr old    1028 larva L3 puffstage 1-2    1174 larva L3 puffstage 3-6    1311 larva L3 puffstage 7-9  (1634) white prepupae new  (2492) white prepupae 12hr  (2430) white prepupae 24hr    1297 pupae 2d postWPP    918 pupae 3d postWPP    646 pupae 4d postWPP    1237 adult male 01day  1449 adult male 05day    1281 adult male 30day  (1517) adult female 01day  (1812) adult female 05day    1396 adult female 30day    1371 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1221 embryo 02-04hr    143 embryo 04-06hr    19 embryo 06-08hr    66 embryo 08-10hr    138 embryo 10-12hr    401 embryo 12-14hr    362 embryo 14-16hr    401 embryo 16-18hr    469 embryo 18-20hr    524 embryo 20-22hr    988 embryo 22-24hr    978 larva L1    975 larva L2    1024 larva L3 12hr old    1028 larva L3 puffstage 1-2    1174 larva L3 puffstage 3-6    1311 larva L3 puffstage 7-9    1634 white prepupae new    2492 white prepupae 12hr    2430 white prepupae 24hr    1297 pupae 2d postWPP    918 pupae 3d postWPP    646 pupae 4d postWPP    1237 adult male 01day    1449 adult male 05day    1281 adult male 30day    1517 adult female 01day    1812 adult female 05day    1396 adult female 30day    1371 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1221 embryo 02-04hr    143 embryo 04-06hr    19 embryo 06-08hr    66 embryo 08-10hr    138 embryo 10-12hr    401 embryo 12-14hr    362 embryo 14-16hr    401 embryo 16-18hr    469 embryo 18-20hr    524 embryo 20-22hr    988 embryo 22-24hr    978 larva L1    975 larva L2    1024 larva L3 12hr old    1028 larva L3 puffstage 1-2    1174 larva L3 puffstage 3-6    1311 larva L3 puffstage 7-9    1634 white prepupae new    2492 white prepupae 12hr    2430 white prepupae 24hr    1297 pupae 2d postWPP    918 pupae 3d postWPP    646 pupae 4d postWPP    1237 adult male 01day    1449 adult male 05day    1281 adult male 30day    1517 adult female 01day    1812 adult female 05day    1396 adult female 30day    1371 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0039061 expression level Developmental Stage   Expression Level embryo 00-02hr    1221 embryo 02-04hr    143 embryo 04-06hr    19 embryo 06-08hr    66 embryo 08-10hr    138 embryo 10-12hr    401 embryo 12-14hr    362 embryo 14-16hr    401 embryo 16-18hr    469 embryo 18-20hr    524 embryo 20-22hr    988 embryo 22-24hr    978 larva L1    975 larva L2    1024 larva L3 12hr old    1028 larva L3 puffstage 1-2    1174 larva L3 puffstage 3-6    1311 larva L3 puffstage 7-9    1634 white prepupae new    2492 white prepupae 12hr    2430 white prepupae 24hr    1297 pupae 2d postWPP    918 pupae 3d postWPP    646 pupae 4d postWPP    1237 adult male 01day    1449 adult male 05day    1281 adult male 30day    1517 adult female 01day    1812 adult female 05day    1396 adult female 30day    1371 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1221) embryo 02-04hr  143 embryo 04-06hr    19 embryo 06-08hr    66 embryo 08-10hr  138 embryo 10-12hr  (401) embryo 12-14hr  (362) embryo 14-16hr  (401) embryo 16-18hr  (469) embryo 18-20hr  (524) embryo 20-22hr  (988) embryo 22-24hr  (978) larva L1  (975) larva L2  (1024) larva L3 12hr old  (1028) larva L3 puffstage 1-2  (1174) larva L3 puffstage 3-6  (1311) larva L3 puffstage 7-9  (1634) white prepupae new  (2492) white prepupae 12hr  (2430) white prepupae 24hr  (1297) pupae 2d postWPP  (918) pupae 3d postWPP  (646) pupae 4d postWPP  (1237) adult male 01day  (1449) adult male 05day  (1281) adult male 30day  (1517) adult female 01day  (1812) adult female 05day  (1396) adult female 30day  (1371) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1221 embryo 02-04hr    143 embryo 04-06hr    19 embryo 06-08hr    66 embryo 08-10hr    138 embryo 10-12hr    401 embryo 12-14hr    362 embryo 14-16hr    401 embryo 16-18hr    469 embryo 18-20hr    524 embryo 20-22hr    988 embryo 22-24hr    978 larva L1    975 larva L2    1024 larva L3 12hr old    1028 larva L3 puffstage 1-2    1174 larva L3 puffstage 3-6    1311 larva L3 puffstage 7-9  1634 white prepupae new  (2492) white prepupae 12hr  2430 white prepupae 24hr    1297 pupae 2d postWPP    918 pupae 3d postWPP    646 pupae 4d postWPP    1237 adult male 01day  1449 adult male 05day    1281 adult male 30day  1517 adult female 01day  1812 adult female 05day    1396 adult female 30day    1371 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1221 embryo 02-04hr    143 embryo 04-06hr    19 embryo 06-08hr    66 embryo 08-10hr    138 embryo 10-12hr    401 embryo 12-14hr    362 embryo 14-16hr    401 embryo 16-18hr    469 embryo 18-20hr    524 embryo 20-22hr    988 embryo 22-24hr    978 larva L1    975 larva L2    1024 larva L3 12hr old    1028 larva L3 puffstage 1-2    1174 larva L3 puffstage 3-6    1311 larva L3 puffstage 7-9    1634 white prepupae new    2492 white prepupae 12hr    2430 white prepupae 24hr    1297 pupae 2d postWPP    918 pupae 3d postWPP    646 pupae 4d postWPP    1237 adult male 01day    1449 adult male 05day    1281 adult male 30day    1517 adult female 01day    1812 adult female 05day    1396 adult female 30day    1371 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1221 embryo 02-04hr    143 embryo 04-06hr    19 embryo 06-08hr    66 embryo 08-10hr    138 embryo 10-12hr    401 embryo 12-14hr    362 embryo 14-16hr    401 embryo 16-18hr    469 embryo 18-20hr    524 embryo 20-22hr    988 embryo 22-24hr    978 larva L1    975 larva L2    1024 larva L3 12hr old    1028 larva L3 puffstage 1-2    1174 larva L3 puffstage 3-6    1311 larva L3 puffstage 7-9    1634 white prepupae new    2492 white prepupae 12hr    2430 white prepupae 24hr    1297 pupae 2d postWPP    918 pupae 3d postWPP    646 pupae 4d postWPP    1237 adult male 01day    1449 adult male 05day    1281 adult male 30day    1517 adult female 01day    1812 adult female 05day    1396 adult female 30day    1371 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0039061    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0039061 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval/adult midgut, larval/adult Malpighian tubules, larval/adult salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult crop, larval hindgut, larval trachea, adult ovary, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0039061 expression level Tissue   Expression Level Larval Central Nervous System    55.075 Larval Midgut    782.1 Larval Hindgut    302 Larval Malpighian Tubules    844.2 Larval Fat Body    87.5 Larval Salivary Gland    725.4 Larval Trachea    166.225 Larval Carcass    221.025 Adult Head    115.5 Adult Eye    76.725 Adult Brain    32.4 Adult Thoracic-Abdominal Ganglion    78.6 Adult Crop    281.2 Adult Midgut    506.5 Adult Hindgut    83.4 Adult Malpighian Tubules    1099.3 Adult Fat Body    41.5 Adult Salivary Gland    7480.9 Adult Heart    32.1 Adult VirginFemale Spermatheca    80.1 Adult InseminatedFemale Spermatheca    98.5 Adult Ovary    202.9 Adult Testis    6.6 Adult Male Accessory Gland    122.4 Adult Carcass    125.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    55.075 Larval Midgut  (782.1) Larval Hindgut    302 Larval Malpighian Tubules  (844.2) Larval Fat Body    87.5 Larval Salivary Gland  (725.4) Larval Trachea    166.225 Larval Carcass    221.025 Adult Head    115.5 Adult Eye    76.725 Adult Brain    32.4 Adult Thoracic-Abdominal Ganglion    78.6 Adult Crop    281.2 Adult Midgut  506.5 Adult Hindgut    83.4 Adult Malpighian Tubules  (1099.3) Adult Fat Body    41.5 Adult Salivary Gland  (7480.9) Adult Heart    32.1 Adult VirginFemale Spermatheca    80.1 Adult InseminatedFemale Spermatheca    98.5 Adult Ovary    202.9 Adult Testis    6.6 Adult Male Accessory Gland    122.4 Adult Carcass    125.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    55.075 Larval Midgut    782.1 Larval Hindgut    302 Larval Malpighian Tubules    844.2 Larval Fat Body    87.5 Larval Salivary Gland    725.4 Larval Trachea    166.225 Larval Carcass    221.025 Adult Head    115.5 Adult Eye    76.725 Adult Brain    32.4 Adult Thoracic-Abdominal Ganglion    78.6 Adult Crop    281.2 Adult Midgut    506.5 Adult Hindgut    83.4 Adult Malpighian Tubules  (1099.3) Adult Fat Body    41.5 Adult Salivary Gland  (7480.9) Adult Heart    32.1 Adult VirginFemale Spermatheca    80.1 Adult InseminatedFemale Spermatheca    98.5 Adult Ovary    202.9 Adult Testis    6.6 Adult Male Accessory Gland    122.4 Adult Carcass    125.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    55.075 Larval Midgut    782.1 Larval Hindgut    302 Larval Malpighian Tubules    844.2 Larval Fat Body    87.5 Larval Salivary Gland    725.4 Larval Trachea    166.225 Larval Carcass    221.025 Adult Head    115.5 Adult Eye    76.725 Adult Brain    32.4 Adult Thoracic-Abdominal Ganglion    78.6 Adult Crop    281.2 Adult Midgut    506.5 Adult Hindgut    83.4 Adult Malpighian Tubules    1099.3 Adult Fat Body    41.5 Adult Salivary Gland    7480.9 Adult Heart    32.1 Adult VirginFemale Spermatheca    80.1 Adult InseminatedFemale Spermatheca    98.5 Adult Ovary    202.9 Adult Testis    6.6 Adult Male Accessory Gland    122.4 Adult Carcass    125.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0039061 expression level Tissue   Expression Level Larval Central Nervous System    55.075 Larval Midgut    782.1 Larval Hindgut    302 Larval Malpighian Tubules    844.2 Larval Fat Body    87.5 Larval Salivary Gland    725.4 Larval Trachea    166.225 Larval Carcass    221.025 Adult Head    115.5 Adult Eye    76.725 Adult Brain    32.4 Adult Thoracic-Abdominal Ganglion    78.6 Adult Crop    281.2 Adult Midgut    506.5 Adult Hindgut    83.4 Adult Malpighian Tubules    1099.3 Adult Fat Body    41.5 Adult Salivary Gland    7480.9 Adult Heart    32.1 Adult VirginFemale Spermatheca    80.1 Adult InseminatedFemale Spermatheca    98.5 Adult Ovary    202.9 Adult Testis    6.6 Adult Male Accessory Gland    122.4 Adult Carcass    125.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    55.075 Larval Midgut  782.1 Larval Hindgut    302 Larval Malpighian Tubules  (844.2) Larval Fat Body    87.5 Larval Salivary Gland  725.4 Larval Trachea    166.225 Larval Carcass    221.025 Adult Head    115.5 Adult Eye    76.725 Adult Brain    32.4 Adult Thoracic-Abdominal Ganglion    78.6 Adult Crop    281.2 Adult Midgut  506.5 Adult Hindgut    83.4 Adult Malpighian Tubules  (1099.3) Adult Fat Body    41.5 Adult Salivary Gland  (7480.9) Adult Heart    32.1 Adult VirginFemale Spermatheca    80.1 Adult InseminatedFemale Spermatheca    98.5 Adult Ovary    202.9 Adult Testis    6.6 Adult Male Accessory Gland    122.4 Adult Carcass    125.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    55.075 Larval Midgut    782.1 Larval Hindgut    302 Larval Malpighian Tubules    844.2 Larval Fat Body    87.5 Larval Salivary Gland    725.4 Larval Trachea    166.225 Larval Carcass    221.025 Adult Head    115.5 Adult Eye    76.725 Adult Brain    32.4 Adult Thoracic-Abdominal Ganglion    78.6 Adult Crop    281.2 Adult Midgut    506.5 Adult Hindgut    83.4 Adult Malpighian Tubules  1099.3 Adult Fat Body    41.5 Adult Salivary Gland  (7480.9) Adult Heart    32.1 Adult VirginFemale Spermatheca    80.1 Adult InseminatedFemale Spermatheca    98.5 Adult Ovary    202.9 Adult Testis    6.6 Adult Male Accessory Gland    122.4 Adult Carcass    125.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    55.075 Larval Midgut    782.1 Larval Hindgut    302 Larval Malpighian Tubules    844.2 Larval Fat Body    87.5 Larval Salivary Gland    725.4 Larval Trachea    166.225 Larval Carcass    221.025 Adult Head    115.5 Adult Eye    76.725 Adult Brain    32.4 Adult Thoracic-Abdominal Ganglion    78.6 Adult Crop    281.2 Adult Midgut    506.5 Adult Hindgut    83.4 Adult Malpighian Tubules    1099.3 Adult Fat Body    41.5 Adult Salivary Gland    7480.9 Adult Heart    32.1 Adult VirginFemale Spermatheca    80.1 Adult InseminatedFemale Spermatheca    98.5 Adult Ovary    202.9 Adult Testis    6.6 Adult Male Accessory Gland    122.4 Adult Carcass    125.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    115.5   NA  Eye    76.725   NA  Brain    32.4   55.075  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    78.6   NA  Crop    281.2   782.1  Midgut    506.5   302  Hindgut    83.4   844.2  Malpighian Tubules    1099.3   87.5  Fat Body    41.5   725.4  Salivary Gland    7480.9   NA  Heart    32.1   166.225  Trachea    NA   NA  VirginFemale Spermatheca    80.1   NA  InseminatedFemale Spermatheca    98.5   NA  Ovary    202.9   NA  Testis    6.6   NA  Male Accessory Gland    122.4   221.025  Carcass    125.3 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_10
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039061 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6747-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 IrGD12824 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 IrGD12824 Phenotype manifest in Allele mesothoracic tergum, with Scer\GAL4pnr-MD237 IrGD12824 trichogen cell, with Scer\GAL4pnr-MD237 IrGD12824
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of Ir Class Mutagen Stocks Known lesion Ire00325 1 -- IrMB08423 1 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Ir Class Mutagen Stocks Known lesion IrGD12824 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes IrJF01841 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes IrKK102249 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes IrAct5C.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6274 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD12824} NA P{KK102249} NA P{TRiP.JF01841} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{RB}Ire00325 NA insertion of enhancer trap binary system Mi{ET1}IrMB08423 No
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function
CV term Evidence References
inward rectifier potassium channel activity inferred from direct assay (Doring et al., 2002)
Biological Process
CV term Evidence References
potassium ion transport inferred from direct assay (Doring et al., 2002) regulation of membrane potential inferred from direct assay (Doring et al., 2002)
Cellular Component
CV term Evidence References
integral to membrane inferred from direct assay (Doring et al., 2002)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
ATP-activated inward rectifier potassium channel activity inferred from sequence or structural similarity with UniProtKB:P52188 (FlyBase, 1992-) inward rectifier potassium channel activity non-traceable author statement (Doering, 2001.9.3)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Ir allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0039061
Orthologs
Genome-wide drosophilid orthologs	Dana\GF16984 Dere\GG11193 Dgri\GH19549 Dmoj\GI22262 Dper\GL24490 Dpse\GA19830 Dsec\GM26492 Dsim\GD21006 Dvir\GJ24053 Dwil\GK14058 Dyak\GE10360
Curated drosophilid orthologs	Dpse\GA19830
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL008932-PA Aedes aegypti (mosquito) AGAP001280-PA Anopheles gambiae (mosquito) XP_392010.3 Apis mellifera (honey bee) XP_001949404.1 Acyrthosiphon pisum (pea aphid) 128229 Branchiostoma floridae (lancelet) BGIBMGA007034-PA Bombyx mori (silk worm) ENSBTAP00000033973 Bos taurus (bovine) CN06950 Caenorhabditis brenneri (small nematode) CBP27693 Caenorhabditis briggsae (nematode) CE07387 Caenorhabditis elegans (worm) ENSCAFP00000027352 Canis familiaris (dog) ENSCINP00000016903 Ciona intestinalis (sea squirt) JA06498 Caenorhabditis japonica (nematode) CPIJ017135 Culex pipens (mosquito) ENSCPOP00000015208 Cavia porcellus (guinea pig) 169948 Chlamidomonas reinhardtii (green alga) RP29565 Caenorhabditis remanei (nematode) ENSCSAVP00000019853 Ciona savignyi (sedentary tunicate) 3998 Capitella spl (polychaete worm) 311738 Daphnia pulex (daphnia) ENSDARP00000079165 Danio rerio (zebra fish) ENSECAP00000002476 Equus caballus (horse) ENSGACP00000017159 Gymnopilus aculeatus (mushroom) ENSGALP00000001788 Gallus gallus (chicken) 106279 Hypsipyla robusta (cedar shoot borer) ENSP00000328150 Homo sapiens (human) ISCW016219-PA Ixodes scapularis (deer tick) 131645 Lottia gigantea (owl limpet) ENSMODP00000021264 Monodelphis domestica (gray opossum) ENSMMUP00000014304 Macaca mulatta (rhesus monkey) ENSMUSP00000041696 Mus musculus (house mouse) 93919 Nematostella vectensis (starlet anemone) XP_001607604.1 Nasonia vitripennis (wasp) ENSOANP00000012318 Ornithorynchus anatinus (platypus) ENSOANP00000012841 Ornithorynchus anatinus (platypus) ENSORLP00000005092 Oryzias latipes (japanese killifish) ENSPPYP00000000751 Pongo pygmaeus (orangutan) 128732 Phytophthora sojae (root rot pathogen) ENSPTRP00000053885 Pan troglodytes (chimpanzee) ENSRNOP00000054762 Rattus norvegicus (norway rat) XP_797173.1 Strongylocentrotus purpuratus (purple sea urchin) 3835 Trichoplax adhaerens (metazoa) XP_974184.2 Tribolium castaneum (red flour beetle) ENSTNIP00000007179 Tetraodon nigroviridis (green spotted pufferfish) ENSTNIP00000015820 Tetraodon nigroviridis (green spotted pufferfish) 25330 Thalassiosira pseudonana (marine diatom) 5256 Thalassiosira pseudonana (marine diatom) ENSTRUP00000000108 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000038651 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14144 NV14143 LH19041 LH19038 ISCW016219 FBgn0228227 FBgn0068135 FBgn0216064 FBgn0215164 FBgn0214276 FBgn0211140 FBgn0210225 FBgn0192461 FBgn0189907 FBgn0181345 FBgn0178430 JGI_V11_311738 FBgn0079826 FBgn0078146 FBgn0162079 FBgn0151452 FBgn0144990 FBgn0133472 FBgn0039081 FBgn0128231 FBgn0127013 FBgn0104720 FBgn0103494 FBgn0095780 FBgn0094003 CPIJ017135 CPIJ017138 BGIBMGA007070 BGIBMGA007034 ACYPI007397 ACYPI001807 GB17183 GB10519 AGAP001284 AGAP001281 AGAP001283 AGAP001280 AAEL008932 AAEL008928 PB21978 PHUM083610 GLEAN_06706 GLEAN_01199
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	26372 w1118; Mi{ET1}IrMB08423 25823 y1 v1; P{TRiP.JF01841}attP2
Harvard	- PBac{RB}Ire00325
VDRC	v107389 P{KK102249}VIE-260B v28430 w1118; P{GD12824}v28430 v28431 w1118; P{GD12824}v28431
Genomic Clones ( 2 )
	BACR03N12 BACR17P04 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 22 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones	FI12006 IP03029 IP17244
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RH38792 SD15336
Other clones	29639 39234 147079 156378 524328 EK152223 EK253842 EK259525 ESG015a.E21_B06 ESG015b.E21_B06 ESG0113d.B21_D12 ESG0115c.B21_F04 IP02829 IP02929 IP03129 IP17344 IP17544
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0039061 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42742
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Ir CG6747 (FlyBase, 1996-)
Source for database merge of
Additional comments	Source for identity of Ir CG6747 was sequence comparison (date:011219). (FlyBase, 1996-)
Other Comments
	Gene expression is increased in response to the presence of either one or two copies of Scer\GAL4hs.PB. (Liu and Lehmann, 2008)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_142874 NM_001104414 NM_001170226 NM_001202341 RefSeq (Proteins) • NP_651131 NP_001097884 NP_001163697 NP_001189270 DDBJ / EMBL / GenBank • AAF56107 AAK98804 ABW08737 ACZ94992 ADV37361 AJ344344 AY044166 CAC87637 Entrez Gene - A searchable database of RefSeq genes. • 42742 UniProtKB/TrEMBL • A8JR87 E1JIU2 Q9VCQ0 Q95UP7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Potassium channel, inwardly rectifying, Kir-like (IPR001838) Potassium channel, inwardly rectifying, Kir, conserved region 2 (IPR013521) Potassium channel, inwardly rectifying, Kir, cytoplasmic (IPR013518) Immunoglobulin E-set (IPR014756) Potassium channel, inwardly rectifying, Kir (IPR016449)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0039061 DRSC - Results from RNAi screens. • FBgn0039061 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039061 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6747-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0039061 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42742 InParanoid A subset of ortholog calls from InParanoid. • AAEL008932-PA Aedes aegypti (mosquito) AGAP001280-PA Anopheles gambiae (mosquito) XP_392010.3 Apis mellifera (honey bee) XP_001949404.1 Acyrthosiphon pisum (pea aphid) 128229 Branchiostoma floridae (lancelet) BGIBMGA007034-PA Bombyx mori (silk worm) ENSBTAP00000033973 Bos taurus (bovine) CN06950 Caenorhabditis brenneri (small nematode) CBP27693 Caenorhabditis briggsae (nematode) CE07387 Caenorhabditis elegans (worm) ENSCAFP00000027352 Canis familiaris (dog) ENSCINP00000016903 Ciona intestinalis (sea squirt) JA06498 Caenorhabditis japonica (nematode) CPIJ017135 Culex pipens (mosquito) ENSCPOP00000015208 Cavia porcellus (guinea pig) 169948 Chlamidomonas reinhardtii (green alga) RP29565 Caenorhabditis remanei (nematode) ENSCSAVP00000019853 Ciona savignyi (sedentary tunicate) 3998 Capitella spl (polychaete worm) 311738 Daphnia pulex (daphnia) ENSDARP00000079165 Danio rerio (zebra fish) ENSECAP00000002476 Equus caballus (horse) ENSGACP00000017159 Gymnopilus aculeatus (mushroom) ENSGALP00000001788 Gallus gallus (chicken) 106279 Hypsipyla robusta (cedar shoot borer) ENSP00000328150 Homo sapiens (human) ISCW016219-PA Ixodes scapularis (deer tick) 131645 Lottia gigantea (owl limpet) ENSMODP00000021264 Monodelphis domestica (gray opossum) ENSMMUP00000014304 Macaca mulatta (rhesus monkey) ENSMUSP00000041696 Mus musculus (house mouse) 93919 Nematostella vectensis (starlet anemone) XP_001607604.1 Nasonia vitripennis (wasp) ENSOANP00000012318 Ornithorynchus anatinus (platypus) ENSOANP00000012841 Ornithorynchus anatinus (platypus) ENSORLP00000005092 Oryzias latipes (japanese killifish) ENSPPYP00000000751 Pongo pygmaeus (orangutan) 128732 Phytophthora sojae (root rot pathogen) ENSPTRP00000053885 Pan troglodytes (chimpanzee) ENSRNOP00000054762 Rattus norvegicus (norway rat) XP_797173.1 Strongylocentrotus purpuratus (purple sea urchin) 3835 Trichoplax adhaerens (metazoa) XP_974184.2 Tribolium castaneum (red flour beetle) ENSTNIP00000007179 Tetraodon nigroviridis (green spotted pufferfish) ENSTNIP00000015820 Tetraodon nigroviridis (green spotted pufferfish) 25330 Thalassiosira pseudonana (marine diatom) 5256 Thalassiosira pseudonana (marine diatom) ENSTRUP00000000108 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000038651 Xenopus tropicalis (frog) modMine - Data generated by the modENCODE project. • FBgn0039061 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14144 NV14143 LH19041 LH19038 ISCW016219 FBgn0228227 FBgn0068135 FBgn0216064 FBgn0215164 FBgn0214276 FBgn0211140 FBgn0210225 FBgn0192461 FBgn0189907 FBgn0181345 FBgn0178430 JGI_V11_311738 FBgn0079826 FBgn0078146 FBgn0162079 FBgn0151452 FBgn0144990 FBgn0133472 FBgn0039081 FBgn0128231 FBgn0127013 FBgn0104720 FBgn0103494 FBgn0095780 FBgn0094003 CPIJ017135 CPIJ017138 BGIBMGA007070 BGIBMGA007034 ACYPI007397 ACYPI001807 GB17183 GB10519 AGAP001284 AGAP001281 AGAP001283 AGAP001280 AAEL008932 AAEL008928 PB21978 PHUM083610 GLEAN_06706 GLEAN_01199
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	CG6747 (Wang et al., 2004, Perkins et al., 1.15.2009, Keleman et al., 2009.8.5, Piacentini et al., 2009) Dir (MacLean et al., 2002) DIR (MacLean, 2001.7.6) dKirI (Doring et al., 2002) Ir (Geng and MacDonald, 2007, Liu and Lehmann, 2008, Wang et al., 2004, Qian and Bodmer, 2009, Kula-Eversole et al., 2010, Nagoshi et al., 2010) ir (Evans et al., 2005) irk1 (Doering, 2001.9.3) Irk1 (McCormack, 2003)
Name Synonym	Drosophila inward rectifier (MacLean et al., 2002) Inwardly rectifying potassium channel (Qian and Bodmer, 2009)
Secondary FlyBase IDs
References ( 27 )
Generate a list of	All references relating to this gene ( 27 )
List References by type	Research paper  ( 12 ) Supplementary material  ( 2 ) Personal communication to FlyBase  ( 6 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 2 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 2 )
	Kula-Eversole et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(30): 13497--13502 Surprising gene expression patterns within and between PDF-containing circadian neurons in Drosophila. [FBrf0211416] Nagoshi et al., 2010, Nat. Neurosci. 13(1): 60--68 Dissecting differential gene expression within the circadian neuronal circuit of Drosophila. [FBrf0209632] Show all research papers ...