FlyBase Gene Report: Dmel\EloA

General Information

Symbol

Dmel\EloA

Species

D. melanogaster

Name

Elongin A

Annotation Symbol

CG6755

Feature Type

protein_coding_gene

FlyBase ID

FBgn0039066

Gene Model Status

Current

Stock Availability

6 publicly available

Gene Summary

Elongin A (EloA) encodes a transcription elongation factor that enhances the catalytic rate of RNA Polymerase II by suppressing its transient pausing. It associates with the products of EloB and EloC. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

dEloA

Key Links

Genomic Location

Cytogenetic map

94E9-94E9

Sequence location

3R:23,251,563..23,255,071 [+]

Recombination map

3-78

RefSeq locus

NT_033777 REGION:23251563..23255071

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (6 terms)

Molecular Function (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in imaginal disc-derived wing vein specification

inferred from mutant phenotype

(Rougeot et al., 2013)

inferred from genetic interaction with FLYBASE:corto; FB:FBgn0010313

(Rougeot et al., 2013)

involved_in transcription elongation by RNA polymerase II

inferred from direct assay

(Gerber et al., 2004)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in transcription elongation by RNA polymerase II

inferred from sequence or structural similarity with UniProtKB:Q63187

(Gene Ontology Curators, 2002-)

inferred from electronic annotation with InterPro:IPR010684

(InterPro Project Members, 2004-)

inferred by curator from GO:0070449

(Rougeot et al., 2013)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

part_of elongin complex

inferred from direct assay

(Rougeot et al., 2013)

colocalizes_with euchromatin

inferred from direct assay

(Gerber et al., 2004)

located_in nucleus

inferred from direct assay

(Gerber et al., 2004)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

part_of elongin complex

inferred from electronic annotation with InterPro:IPR010684

(InterPro Project Members, 2004-)

inferred from sequence or structural similarity with RGD:3827

(Gerber et al., 2004)

located_in nucleus

inferred from electronic annotation with InterPro:IPR003617, InterPro:IPR010684

(InterPro Project Members, 2004-)

part_of transcription elongation factor complex

inferred from sequence or structural similarity with UniProtKB:Q63187

(Gene Ontology Curators, 2002-)

Gene Group (FlyBase)

ELONGIN COMPLEX

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

ELONGIN COMPLEX -: Elongin complex is a transcription elongation factor that increases RNA polymerase II elongation rate by suppressing transient pausing. Elongin complex is a heterotrimer composed of the large transcriptionally active subunit elongin A and two regulatory subunits elongin B and C, which form a stable subcomplex that binds to subunit A. (Adapted from FBrf0223250 and FBrf0180540).

Protein Function (UniProtKB)

SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). May play an important role in metamorphosis.

(UniProt, Q9VCP0)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\EloA for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VCP0)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

EloA-RA

FBtr0084374

NM_170061

2869

643

EloA-RB

FBtr0084375

NM_142878

2697

566

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

EloA-PA

FBpp0083766

71.2

643

10.45

FBpp0083767

62.5

566

10.45

NP_651135

AAN13934

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Domain

The elongin BC complex binding domain is also known as BC-box with the consensus

(UniProt, Q9VCP0)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9VCP0

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\EloA using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

EloA_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.60

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

central brain anlage in statu nascendi

(Fisher et al., 2012)

dorsal ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

organism | pair rule expression pattern

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

ventral ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

embryonic stage 7 -- 8

antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

dorsal ectoderm

(Fisher et al., 2012)

mesectoderm

(Fisher et al., 2012)

organism | pair rule expression pattern

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

ventral nerve cord primordium

Comment: reported as ventral nerve cord anlage

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | pair rule expression pattern

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | faint | ubiquitous

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

organism | faint | ubiquitous

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of elongin complex

inferred from direct assay

(Rougeot et al., 2013)

colocalizes_with euchromatin

inferred from direct assay

(Gerber et al., 2004)

located_in nucleus

inferred from direct assay

(Gerber et al., 2004)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\EloA in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\EloA

View exonic expression by tissue for Dmel\EloA

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0039066

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42749/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0039066

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0039066

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0039066

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6755

Flygut - An atlas of the Drosophila adult midgut

FBgn0039066

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\EloA

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 1 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 5 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of EloA

Transgenic constructs containing regulatory region of EloA

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(3R)Exel6274

(Ryder, 2004.4.26)

Df(3R)Exel6280

(Ryder, 2004.4.26)

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

EloA^GD1290

lethal, with Scer\GAL4^Act5C.PU

EloA^RNAi.Sym.UAS

lethal - all die before end of pupal stage, with Scer\GAL4^da.G32

EloA^RNAi.Sym.UAS

lethal - all die during embryonic stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

EloA^GD1290

viable

EloA^G4930

viable, with Scer\GAL4^Mef2.PR

EloA^GD1290

viable, with Scer\GAL4^pnr-MD237

EloA^GD1290

viable, with Scer\GAL4^tin.CΔ4

EloA^GD1290

Other Phenotypes

Allele

some die during pupal stage, with Scer\GAL4^da.G32

EloA^RNAi.Sym.UAS

visible, with Scer\GAL4^Bx-MS1096

EloA^G4930

visible, with Scer\GAL4^sd.PU

EloA^G4930

visible | somatic clone, with Scer\GAL4^Act5C.PP

EloA^G4930

Phenotype manifest in

Allele

wing margin, with Scer\GAL4^sd.PU

EloA^G4930

wing margin | somatic clone, with Scer\GAL4^Act5C.PP

EloA^G4930

wing vein | ectopic, with Scer\GAL4^Bx-MS1096

EloA^G4930

wing vein | ectopic, with Scer\GAL4^sd.PU

EloA^G4930

wing vein | somatic clone, with Scer\GAL4^Act5C.PP

EloA^G4930

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (12)

Hsap\ELOA2

13 of 14

Yes

Hsap\ELOA

12 of 14

Yes

Hsap\ELOA3DP

9 of 14

Yes

Hsap\ELOA3BP

8 of 14

Yes

Hsap\ELOA3P

7 of 14

Yes

Hsap\ELOA3CP

6 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (8)

Rnor\Eloa

13 of 14

Yes

Rnor\LOC683469

4 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (7)

Mmus\Eloa

12 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (6)

Xtro\LOC100497894

10 of 13

Yes

Xtro\eloa

9 of 13

Yes

2 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (7)

Drer\eloal

13 of 14

Yes

Drer\eloa

8 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (6)

Cele\tceb-3

9 of 14

Yes

Cele\B0212.3

1 of 14

Yes

Cele\K09F5.1

1 of 14

Yes

Cele\M57.1

1 of 14

Yes

Cele\T23E1.3

1 of 14

Yes

Cele\T24H10.1

1 of 14

Anopheles gambiae (African malaria mosquito) (3)

Agam\AgaP_AGAP004363

12 of 12

Yes

Agam\AgaP_AGAP004866

1 of 12

Agam\AgaP_AGAP009035

1 of 12

Arabidopsis thaliana (thale-cress) (6)

Atha\AT2G42780

3 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\ELA1

3 of 13

Yes

Scer\DST1

1 of 13

Schizosaccharomyces pombe (Fission yeast) (3)

Spom\pof4

7 of 12

Yes

Spom\SPCC645.13

1 of 12

Spom\tfs1

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:EloA. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (3)

CG8117

1 of 13

pps

1 of 13

TfIIS

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

EloA^KK101126

model of candidiasis

CEA

(Glittenberg et al., 2022)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

EloA^GD1290

ameliorates Machado-Joseph disease

modeled by Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Voßfeldt et al., 2012)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

13 of 14

12 of 14

ELOA3DP; elongin A3 family member D, pseudogene

9 of 14

ELOA3BP; elongin A3 family member B, pseudogene

8 of 14

ELOA3P; elongin A3, pseudogene

7 of 14

ELOA3CP; elongin A3 family member C, pseudogene

6 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

EloA - EloC

anti tag coimmunoprecipitation, anti tag western blot

(Rougeot et al., 2013)

EloA - Polr2A

coimmunoprecipitation, western blot

(Gerber et al., 2004)

EloA - corto

anti tag coimmunoprecipitation, anti tag western blot

(Rougeot et al., 2013)

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

corto

suppressible

EloA

(Rougeot et al., 2013)

kis

suppressible

EloA

(Rougeot et al., 2013)

mor

suppressible

EloA

(Rougeot et al., 2013)

trx

suppressible

EloA

(Rougeot et al., 2013)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

67692

DroID - A comprehensive database of gene and protein interactions.

FBgn0039066

MIST (protein-protein) - An integrated Molecular Interaction Database

42749

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-78

Cytogenetic map

94E9-94E9

Sequence location

3R:23,251,563..23,255,071 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

94E9-94E9

Limits computationally determined from genome sequence between P{PZ}cnc⁰³⁹²¹ and P{PZ}l(3)06906⁰⁶⁹⁰⁶

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-78

(FlyBase, 2016)

3-79.9

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (6)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

30108

w¹¹¹⁸; P{EP}EloA^G4930

81676

y¹ sc^* v¹ sev²¹; P{TOE.GS02735}attP40

37017

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01255}attP2

NIG-Fly

HMS01255

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01255}attP2

VDRC

v110387

P{KK101126}VIE-260B

v6282

w¹¹¹⁸; P{GD1290}v6282

Genomic Clones (20)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (128)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

FI18652

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0039066

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0039066

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

The Elongin complex (comprising EloA, EloB and EloC) appears to participate in vein vs intervein specification in the wing, antagonising corto and several trithorax group genes (mor, kis and trx) in this process.

(Rougeot et al., 2013)

Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days.

(Claridge-Chang et al., 2001)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: EloA CG6755

(Gerber et al., 2004)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

CG6755

(Glittenberg et al., 2022, Rougeot et al., 2013, Ni et al., 2011.7.19, Ardehali et al., 2009, Keleman et al., 2009.8.5, Gandhi et al., 2007, Molnar et al., 2006, Gerber et al., 2004, Giot et al., 2003, Claridge-Chang et al., 2001)

Elo-A

(Chopra et al., 2009)

EloA

(Wang et al., 2022, Transgenic RNAi Project members, 2017-, Aradska et al., 2015, Kwon et al., 2013, Rougeot et al., 2013, Tenney et al., 2006)

dEloA

(Tenney et al., 2006, Gerber et al., 2005, Gerber et al., 2004)

Name Synonyms

Elongin A

(Chopra and Levine, 2008, Eissenberg et al., 2007, Gerber et al., 2004)

Elongin-A

(Chopra et al., 2009)

ElonginA

(Ardehali et al., 2009)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 44 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

42749

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VCP0

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VCP0

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VCP0

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0039066

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42749/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0039066

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0039066

FlyMine - An integrated database for Drosophila genomics

FBgn0039066

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG6755

MARRVEL_MODEL - MARRVEL (model organism gene)

42749

Linkouts

BioGRID - A database of protein and genetic interactions.

67692

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0039066

DroID - A comprehensive database of gene and protein interactions.

FBgn0039066

DRSC - Results frm RNAi screens

FBgn0039066

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

EloA_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0039066

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0039066

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6755

Flygut - An atlas of the Drosophila adult midgut

FBgn0039066

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0039066

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC001477

MIST (protein-protein) - An integrated Molecular Interaction Database

42749

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (41)

The following external sites may use different assemblies or annotations than FlyBase.

0.60

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