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Gene Dmel\CG10184

General Information
Symbol	Dmel\CG10184	Species	D. melanogaster
Name		Annotation symbol	CG10184
Feature type	protein_coding_gene	FlyBase ID	FBgn0039094
Gene Model Status	Current	Stock availability	2 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	95A4-95A4	Sequence location	3R:19,428,229..19,431,217 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG10184 (FBgn0039094). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: threonine aldolase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: cellular amino acid metabolic process. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Aromatic amino acid beta-eliminating lyase/threonine aldolase; Pyridoxal phosphate-dependent transferase; Pyridoxal phosphate-dependent transferase, major region, subdomain 1; Pyridoxal phosphate-dependent transferase, major region, subdomain 2; Threonine aldolase. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed during early larval stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult midgut, larval/adult hindgut, larval fat body, larval/adult salivary gland, virgin spermatheca. Comments on Affy2 ProbeSet: ProbeSet 1638132_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG10184. Gene sequence location is 3R:19428229..19431217.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 95A4-95A4   Limits computationally determined from genome sequence between P{PZ}cnc03921 and P{PZ}l(3)0690606906
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG10184 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG10184-RA FBtr0084481  NM_142904   1330   383
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG10184-PA   FBpp0083872   41.2   383   7.00     NP_651161   AAF56152
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Aromatic amino acid beta-eliminating lyase/threonine aldolase (IPR001597) Threonine aldolase (IPR023603) Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (IPR015421) Pyridoxal phosphate-dependent transferase, major region, subdomain 2 (IPR015422) Pyridoxal phosphate-dependent transferase (IPR015424)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA979541   AE014297 AAF56152   AI542899   AW943216   AY051837 AAK93261   BI367085   CO320010   EC076595   EC250463   GH291258   GH779338
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VCK6
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult midgut, larval/adult hindgut, larval fat body, larval/adult salivary gland, virgin spermatheca. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    175.75 Larval Midgut    31.5 Larval Hindgut    239.3 Larval Malpighian Tubules    3.5 Larval Fat Body    122.9 Larval Salivary Gland    124.7 Larval Trachea    19.575 Larval Carcass    22.15 Adult Head    93.8 Adult Eye    70.15 Adult Brain    45.1 Adult Thoracic-Abdominal Ganglion    51.3 Adult Crop    53.7 Adult Midgut    102.9 Adult Hindgut    333.3 Adult Malpighian Tubules    6.7 Adult Fat Body    54.5 Adult Salivary Gland    179 Adult Heart    88.65 Adult VirginFemale Spermatheca    242.5 Adult InseminatedFemale Spermatheca    35 Adult Ovary    52.9 Adult Testis    31.5 Adult Male Accessory Gland    639 Adult Carcass    87.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    175.75 Larval Midgut    31.5 Larval Hindgut    239.3 Larval Malpighian Tubules    3.5 Larval Fat Body    122.9 Larval Salivary Gland    124.7 Larval Trachea    19.575 Larval Carcass    22.15 Adult Head    93.8 Adult Eye    70.15 Adult Brain    45.1 Adult Thoracic-Abdominal Ganglion    51.3 Adult Crop    53.7 Adult Midgut    102.9 Adult Hindgut    333.3 Adult Malpighian Tubules    6.7 Adult Fat Body    54.5 Adult Salivary Gland    179 Adult Heart    88.65 Adult VirginFemale Spermatheca    242.5 Adult InseminatedFemale Spermatheca    35 Adult Ovary    52.9 Adult Testis    31.5 Adult Male Accessory Gland  (639) Adult Carcass    87.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    175.75 Larval Midgut    31.5 Larval Hindgut    239.3 Larval Malpighian Tubules    3.5 Larval Fat Body    122.9 Larval Salivary Gland    124.7 Larval Trachea    19.575 Larval Carcass    22.15 Adult Head    93.8 Adult Eye    70.15 Adult Brain    45.1 Adult Thoracic-Abdominal Ganglion    51.3 Adult Crop    53.7 Adult Midgut    102.9 Adult Hindgut    333.3 Adult Malpighian Tubules    6.7 Adult Fat Body    54.5 Adult Salivary Gland    179 Adult Heart    88.65 Adult VirginFemale Spermatheca    242.5 Adult InseminatedFemale Spermatheca    35 Adult Ovary    52.9 Adult Testis    31.5 Adult Male Accessory Gland    639 Adult Carcass    87.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    175.75 Larval Midgut    31.5 Larval Hindgut    239.3 Larval Malpighian Tubules    3.5 Larval Fat Body    122.9 Larval Salivary Gland    124.7 Larval Trachea    19.575 Larval Carcass    22.15 Adult Head    93.8 Adult Eye    70.15 Adult Brain    45.1 Adult Thoracic-Abdominal Ganglion    51.3 Adult Crop    53.7 Adult Midgut    102.9 Adult Hindgut    333.3 Adult Malpighian Tubules    6.7 Adult Fat Body    54.5 Adult Salivary Gland    179 Adult Heart    88.65 Adult VirginFemale Spermatheca    242.5 Adult InseminatedFemale Spermatheca    35 Adult Ovary    52.9 Adult Testis    31.5 Adult Male Accessory Gland    639 Adult Carcass    87.3 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    175.75 Larval Midgut    31.5 Larval Hindgut    239.3 Larval Malpighian Tubules    3.5 Larval Fat Body    122.9 Larval Salivary Gland    124.7 Larval Trachea    19.575 Larval Carcass    22.15 Adult Head    93.8 Adult Eye    70.15 Adult Brain    45.1 Adult Thoracic-Abdominal Ganglion    51.3 Adult Crop    53.7 Adult Midgut    102.9 Adult Hindgut    333.3 Adult Malpighian Tubules    6.7 Adult Fat Body    54.5 Adult Salivary Gland    179 Adult Heart    88.65 Adult VirginFemale Spermatheca    242.5 Adult InseminatedFemale Spermatheca    35 Adult Ovary    52.9 Adult Testis    31.5 Adult Male Accessory Gland    639 Adult Carcass    87.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    175.75 Larval Midgut    31.5 Larval Hindgut    239.3 Larval Malpighian Tubules    3.5 Larval Fat Body    122.9 Larval Salivary Gland    124.7 Larval Trachea    19.575 Larval Carcass    22.15 Adult Head    93.8 Adult Eye    70.15 Adult Brain    45.1 Adult Thoracic-Abdominal Ganglion    51.3 Adult Crop    53.7 Adult Midgut    102.9 Adult Hindgut    333.3 Adult Malpighian Tubules    6.7 Adult Fat Body    54.5 Adult Salivary Gland    179 Adult Heart    88.65 Adult VirginFemale Spermatheca    242.5 Adult InseminatedFemale Spermatheca    35 Adult Ovary    52.9 Adult Testis    31.5 Adult Male Accessory Gland  639 Adult Carcass    87.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    175.75 Larval Midgut    31.5 Larval Hindgut    239.3 Larval Malpighian Tubules    3.5 Larval Fat Body    122.9 Larval Salivary Gland    124.7 Larval Trachea    19.575 Larval Carcass    22.15 Adult Head    93.8 Adult Eye    70.15 Adult Brain    45.1 Adult Thoracic-Abdominal Ganglion    51.3 Adult Crop    53.7 Adult Midgut    102.9 Adult Hindgut    333.3 Adult Malpighian Tubules    6.7 Adult Fat Body    54.5 Adult Salivary Gland    179 Adult Heart    88.65 Adult VirginFemale Spermatheca    242.5 Adult InseminatedFemale Spermatheca    35 Adult Ovary    52.9 Adult Testis    31.5 Adult Male Accessory Gland    639 Adult Carcass    87.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    175.75 Larval Midgut    31.5 Larval Hindgut    239.3 Larval Malpighian Tubules    3.5 Larval Fat Body    122.9 Larval Salivary Gland    124.7 Larval Trachea    19.575 Larval Carcass    22.15 Adult Head    93.8 Adult Eye    70.15 Adult Brain    45.1 Adult Thoracic-Abdominal Ganglion    51.3 Adult Crop    53.7 Adult Midgut    102.9 Adult Hindgut    333.3 Adult Malpighian Tubules    6.7 Adult Fat Body    54.5 Adult Salivary Gland    179 Adult Heart    88.65 Adult VirginFemale Spermatheca    242.5 Adult InseminatedFemale Spermatheca    35 Adult Ovary    52.9 Adult Testis    31.5 Adult Male Accessory Gland    639 Adult Carcass    87.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    93.8   NA  Eye    70.15   NA  Brain    45.1   175.75  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    51.3   NA  Crop    53.7   no informative data  Midgut    102.9   239.3  Hindgut    333.3   3.5  Malpighian Tubules    6.7   122.9  Fat Body    54.5   124.7  Salivary Gland    179   NA  Heart    88.65   19.575  Trachea    NA   NA  VirginFemale Spermatheca    242.5   NA  InseminatedFemale Spermatheca    35   NA  Ovary    52.9   NA  Testis    31.5   NA  Male Accessory Gland    639   no informative data  Carcass    87.3 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    2 central nervous system, pupae P8    7 head, virgin 1-day female    27 head, virgin 4-day female    7 head, virgin 20-day female    12 head, mated 1-day female    25 head, mated 4-day female    11 head, mated 20-day female    17 head, mated 1-day male    30 head, mated 4-day male    39 head, mated 20-day male    73 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    25 digestive system, 4-day adult    13 digestive system, 20-day adult    19 fat body, larvae L3 wandering    48 fat body, white prepupae    2 fat body, pupae P8    8 carcass, larvae L3 wandering    3 carcass, 1-day adult    17 carcass, 4-day adult    14 carcass, 20-day adult    17 ovary, virgin 4-day female    14 ovary, mated 4-day female    11 testis, mated 4-day male    19 accessory gland, mated 4-day male    46 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    2 central nervous system, pupae P8    7 head, virgin 1-day female  (27) head, virgin 4-day female    7 head, virgin 20-day female    12 head, mated 1-day female    25 head, mated 4-day female    11 head, mated 20-day female    17 head, mated 1-day male  (30) head, mated 4-day male  (39) head, mated 20-day male  (73) salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    25 digestive system, 4-day adult    13 digestive system, 20-day adult    19 fat body, larvae L3 wandering  (48) fat body, white prepupae    2 fat body, pupae P8    8 carcass, larvae L3 wandering    3 carcass, 1-day adult    17 carcass, 4-day adult    14 carcass, 20-day adult    17 ovary, virgin 4-day female    14 ovary, mated 4-day female    11 testis, mated 4-day male    19 accessory gland, mated 4-day male  (46) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    2 central nervous system, pupae P8    7 head, virgin 1-day female    27 head, virgin 4-day female    7 head, virgin 20-day female    12 head, mated 1-day female    25 head, mated 4-day female    11 head, mated 20-day female    17 head, mated 1-day male    30 head, mated 4-day male    39 head, mated 20-day male    73 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    25 digestive system, 4-day adult    13 digestive system, 20-day adult    19 fat body, larvae L3 wandering    48 fat body, white prepupae    2 fat body, pupae P8    8 carcass, larvae L3 wandering    3 carcass, 1-day adult    17 carcass, 4-day adult    14 carcass, 20-day adult    17 ovary, virgin 4-day female    14 ovary, mated 4-day female    11 testis, mated 4-day male    19 accessory gland, mated 4-day male    46 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    2 central nervous system, pupae P8    7 head, virgin 1-day female    27 head, virgin 4-day female    7 head, virgin 20-day female    12 head, mated 1-day female    25 head, mated 4-day female    11 head, mated 20-day female    17 head, mated 1-day male    30 head, mated 4-day male    39 head, mated 20-day male    73 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    25 digestive system, 4-day adult    13 digestive system, 20-day adult    19 fat body, larvae L3 wandering    48 fat body, white prepupae    2 fat body, pupae P8    8 carcass, larvae L3 wandering    3 carcass, 1-day adult    17 carcass, 4-day adult    14 carcass, 20-day adult    17 ovary, virgin 4-day female    14 ovary, mated 4-day female    11 testis, mated 4-day male    19 accessory gland, mated 4-day male    46 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    2 central nervous system, pupae P8    7 head, virgin 1-day female    27 head, virgin 4-day female    7 head, virgin 20-day female    12 head, mated 1-day female    25 head, mated 4-day female    11 head, mated 20-day female    17 head, mated 1-day male    30 head, mated 4-day male    39 head, mated 20-day male    73 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    25 digestive system, 4-day adult    13 digestive system, 20-day adult    19 fat body, larvae L3 wandering    48 fat body, white prepupae    2 fat body, pupae P8    8 carcass, larvae L3 wandering    3 carcass, 1-day adult    17 carcass, 4-day adult    14 carcass, 20-day adult    17 ovary, virgin 4-day female    14 ovary, mated 4-day female    11 testis, mated 4-day male    19 accessory gland, mated 4-day male    46 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    2 central nervous system, pupae P8    7 head, virgin 1-day female  27 head, virgin 4-day female    7 head, virgin 20-day female    12 head, mated 1-day female    25 head, mated 4-day female    11 head, mated 20-day female    17 head, mated 1-day male  30 head, mated 4-day male  (39) head, mated 20-day male  (73) salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    25 digestive system, 4-day adult    13 digestive system, 20-day adult    19 fat body, larvae L3 wandering  (48) fat body, white prepupae    2 fat body, pupae P8    8 carcass, larvae L3 wandering    3 carcass, 1-day adult    17 carcass, 4-day adult    14 carcass, 20-day adult    17 ovary, virgin 4-day female    14 ovary, mated 4-day female    11 testis, mated 4-day male    19 accessory gland, mated 4-day male  (46) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    2 central nervous system, pupae P8    7 head, virgin 1-day female    27 head, virgin 4-day female    7 head, virgin 20-day female    12 head, mated 1-day female    25 head, mated 4-day female    11 head, mated 20-day female    17 head, mated 1-day male    30 head, mated 4-day male    39 head, mated 20-day male    73 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    25 digestive system, 4-day adult    13 digestive system, 20-day adult    19 fat body, larvae L3 wandering    48 fat body, white prepupae    2 fat body, pupae P8    8 carcass, larvae L3 wandering    3 carcass, 1-day adult    17 carcass, 4-day adult    14 carcass, 20-day adult    17 ovary, virgin 4-day female    14 ovary, mated 4-day female    11 testis, mated 4-day male    19 accessory gland, mated 4-day male    46 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    2 central nervous system, pupae P8    7 head, virgin 1-day female    27 head, virgin 4-day female    7 head, virgin 20-day female    12 head, mated 1-day female    25 head, mated 4-day female    11 head, mated 20-day female    17 head, mated 1-day male    30 head, mated 4-day male    39 head, mated 20-day male    73 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    25 digestive system, 4-day adult    13 digestive system, 20-day adult    19 fat body, larvae L3 wandering    48 fat body, white prepupae    2 fat body, pupae P8    8 carcass, larvae L3 wandering    3 carcass, 1-day adult    17 carcass, 4-day adult    14 carcass, 20-day adult    17 ovary, virgin 4-day female    14 ovary, mated 4-day female    11 testis, mated 4-day male    19 accessory gland, mated 4-day male    46 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed during early larval stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    8 embryo 02-04hr    1 embryo 04-06hr    4 embryo 06-08hr    5 embryo 08-10hr    4 embryo 10-12hr    13 embryo 12-14hr    10 embryo 14-16hr    14 embryo 16-18hr    16 embryo 18-20hr    19 embryo 20-22hr    26 embryo 22-24hr    23 larva L1    51 larva L2    45 larva L3 12hr old    61 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    3 white prepupae 24hr    4 pupae 2d postWPP    6 pupae 3d postWPP    7 pupae 4d postWPP    9 adult male 01day    15 adult male 05day    10 adult male 30day    10 adult female 01day    12 adult female 05day    15 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    8 embryo 02-04hr    1 embryo 04-06hr    4 embryo 06-08hr    5 embryo 08-10hr    4 embryo 10-12hr    13 embryo 12-14hr    10 embryo 14-16hr    14 embryo 16-18hr    16 embryo 18-20hr    19 embryo 20-22hr  26 embryo 22-24hr    23 larva L1  (51) larva L2  (45) larva L3 12hr old  (61) larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    3 white prepupae 24hr    4 pupae 2d postWPP    6 pupae 3d postWPP    7 pupae 4d postWPP    9 adult male 01day    15 adult male 05day    10 adult male 30day    10 adult female 01day    12 adult female 05day    15 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    8 embryo 02-04hr    1 embryo 04-06hr    4 embryo 06-08hr    5 embryo 08-10hr    4 embryo 10-12hr    13 embryo 12-14hr    10 embryo 14-16hr    14 embryo 16-18hr    16 embryo 18-20hr    19 embryo 20-22hr    26 embryo 22-24hr    23 larva L1    51 larva L2    45 larva L3 12hr old    61 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    3 white prepupae 24hr    4 pupae 2d postWPP    6 pupae 3d postWPP    7 pupae 4d postWPP    9 adult male 01day    15 adult male 05day    10 adult male 30day    10 adult female 01day    12 adult female 05day    15 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    8 embryo 02-04hr    1 embryo 04-06hr    4 embryo 06-08hr    5 embryo 08-10hr    4 embryo 10-12hr    13 embryo 12-14hr    10 embryo 14-16hr    14 embryo 16-18hr    16 embryo 18-20hr    19 embryo 20-22hr    26 embryo 22-24hr    23 larva L1    51 larva L2    45 larva L3 12hr old    61 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    3 white prepupae 24hr    4 pupae 2d postWPP    6 pupae 3d postWPP    7 pupae 4d postWPP    9 adult male 01day    15 adult male 05day    10 adult male 30day    10 adult female 01day    12 adult female 05day    15 adult female 30day    12 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    8 embryo 02-04hr    1 embryo 04-06hr    4 embryo 06-08hr    5 embryo 08-10hr    4 embryo 10-12hr    13 embryo 12-14hr    10 embryo 14-16hr    14 embryo 16-18hr    16 embryo 18-20hr    19 embryo 20-22hr    26 embryo 22-24hr    23 larva L1    51 larva L2    45 larva L3 12hr old    61 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    3 white prepupae 24hr    4 pupae 2d postWPP    6 pupae 3d postWPP    7 pupae 4d postWPP    9 adult male 01day    15 adult male 05day    10 adult male 30day    10 adult female 01day    12 adult female 05day    15 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    8 embryo 02-04hr    1 embryo 04-06hr    4 embryo 06-08hr    5 embryo 08-10hr    4 embryo 10-12hr    13 embryo 12-14hr    10 embryo 14-16hr    14 embryo 16-18hr    16 embryo 18-20hr    19 embryo 20-22hr  26 embryo 22-24hr    23 larva L1  (51) larva L2  (45) larva L3 12hr old  (61) larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    3 white prepupae 24hr    4 pupae 2d postWPP    6 pupae 3d postWPP    7 pupae 4d postWPP    9 adult male 01day    15 adult male 05day    10 adult male 30day    10 adult female 01day    12 adult female 05day    15 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    8 embryo 02-04hr    1 embryo 04-06hr    4 embryo 06-08hr    5 embryo 08-10hr    4 embryo 10-12hr    13 embryo 12-14hr    10 embryo 14-16hr    14 embryo 16-18hr    16 embryo 18-20hr    19 embryo 20-22hr    26 embryo 22-24hr    23 larva L1    51 larva L2    45 larva L3 12hr old    61 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    3 white prepupae 24hr    4 pupae 2d postWPP    6 pupae 3d postWPP    7 pupae 4d postWPP    9 adult male 01day    15 adult male 05day    10 adult male 30day    10 adult female 01day    12 adult female 05day    15 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    8 embryo 02-04hr    1 embryo 04-06hr    4 embryo 06-08hr    5 embryo 08-10hr    4 embryo 10-12hr    13 embryo 12-14hr    10 embryo 14-16hr    14 embryo 16-18hr    16 embryo 18-20hr    19 embryo 20-22hr    26 embryo 22-24hr    23 larva L1    51 larva L2    45 larva L3 12hr old    61 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    3 white prepupae 24hr    4 pupae 2d postWPP    6 pupae 3d postWPP    7 pupae 4d postWPP    9 adult male 01day    15 adult male 05day    10 adult male 30day    10 adult female 01day    12 adult female 05day    15 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    31 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    1 embryonic Kc167    0 embryonic S1    0 embryonic S3    9 leg disc CME L1    1 wing disc CME-W2    1 wing disc ML-DmD8    5 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    2 tumorous blood cells mbn2    0 ovary fGS/OSS    1 ovary OSC    1 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (31) Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    1 embryonic Kc167    0 embryonic S1    0 embryonic S3    9 leg disc CME L1    1 wing disc CME-W2    1 wing disc ML-DmD8    5 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    2 tumorous blood cells mbn2    0 ovary fGS/OSS    1 ovary OSC    1 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    31 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    1 embryonic Kc167    0 embryonic S1    0 embryonic S3    9 leg disc CME L1    1 wing disc CME-W2    1 wing disc ML-DmD8    5 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    2 tumorous blood cells mbn2    0 ovary fGS/OSS    1 ovary OSC    1 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    31 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    1 embryonic Kc167    0 embryonic S1    0 embryonic S3    9 leg disc CME L1    1 wing disc CME-W2    1 wing disc ML-DmD8    5 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    2 tumorous blood cells mbn2    0 ovary fGS/OSS    1 ovary OSC    1 ovary OSS    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    31 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    1 embryonic Kc167    0 embryonic S1    0 embryonic S3    9 leg disc CME L1    1 wing disc CME-W2    1 wing disc ML-DmD8    5 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    2 tumorous blood cells mbn2    0 ovary fGS/OSS    1 ovary OSC    1 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  31 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    1 embryonic Kc167    0 embryonic S1    0 embryonic S3    9 leg disc CME L1    1 wing disc CME-W2    1 wing disc ML-DmD8    5 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    2 tumorous blood cells mbn2    0 ovary fGS/OSS    1 ovary OSC    1 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    31 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    1 embryonic Kc167    0 embryonic S1    0 embryonic S3    9 leg disc CME L1    1 wing disc CME-W2    1 wing disc ML-DmD8    5 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    2 tumorous blood cells mbn2    0 ovary fGS/OSS    1 ovary OSC    1 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    31 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    1 embryonic Kc167    0 embryonic S1    0 embryonic S3    9 leg disc CME L1    1 wing disc CME-W2    1 wing disc ML-DmD8    5 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    2 tumorous blood cells mbn2    0 ovary fGS/OSS    1 ovary OSC    1 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    4 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    48 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    24 Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3    40 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    19 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    46 Ethanol 10% 3 hrs, larvae L3    40 Caffeine 1.5 mg/ml 4 hrs, larvae L3    20 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    36 Rotenone 8 μg 12 hrs, larvae L3    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    4 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3  (48) Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    24 Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3  (40) Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    19 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3  (46) Ethanol 10% 3 hrs, larvae L3  (40) Caffeine 1.5 mg/ml 4 hrs, larvae L3    20 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3  (36) Rotenone 8 μg 12 hrs, larvae L3  (42) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    4 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    48 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    24 Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3    40 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    19 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    46 Ethanol 10% 3 hrs, larvae L3    40 Caffeine 1.5 mg/ml 4 hrs, larvae L3    20 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    36 Rotenone 8 μg 12 hrs, larvae L3    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    4 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    48 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    24 Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3    40 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    19 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    46 Ethanol 10% 3 hrs, larvae L3    40 Caffeine 1.5 mg/ml 4 hrs, larvae L3    20 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    36 Rotenone 8 μg 12 hrs, larvae L3    42 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    4 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    48 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    24 Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3    40 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    19 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    46 Ethanol 10% 3 hrs, larvae L3    40 Caffeine 1.5 mg/ml 4 hrs, larvae L3    20 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    36 Rotenone 8 μg 12 hrs, larvae L3    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    4 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3  (48) Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    24 Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3  (40) Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    19 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3  (46) Ethanol 10% 3 hrs, larvae L3  (40) Caffeine 1.5 mg/ml 4 hrs, larvae L3    20 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3  (36) Rotenone 8 μg 12 hrs, larvae L3  (42) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    4 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    48 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    24 Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3    40 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    19 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    46 Ethanol 10% 3 hrs, larvae L3    40 Caffeine 1.5 mg/ml 4 hrs, larvae L3    20 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    36 Rotenone 8 μg 12 hrs, larvae L3    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    4 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    48 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    24 Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3    40 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    19 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    46 Ethanol 10% 3 hrs, larvae L3    40 Caffeine 1.5 mg/ml 4 hrs, larvae L3    20 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    36 Rotenone 8 μg 12 hrs, larvae L3    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_20
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039094 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10184-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG10184GD1182 Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of CG10184 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG10184 Class Mutagen Stocks Known lesion CG10184GD1182 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG10184KK109320 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6194 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1182} NA P{KK109320} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{SUPor-P}KG06779 NA
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
pyridoxal phosphate binding inferred from electronic annotation with InterPro:IPR015421, InterPro:IPR015422 (FlyBase Curators et al., 2004-) threonine aldolase activity inferred from sequence or structural similarity with UniProtKB:P37303 (FlyBase, 1992-)
Biological Process
CV term Evidence References
cellular amino acid metabolic process inferred from electronic annotation with InterPro:IPR001597 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
CG10184 - 14-3-3ζ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG10184 - Arpc2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG10184 - Arpc5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG10184 - CG14968 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG10184 - CG15818 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) CG10184 - CG18335 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG10184 - Hsc70-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG10184 - ImpL3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG10184 - Tm1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG10184 - Ykt6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG10184 - regucalcin experimental knowledge based (Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG10184 allele Gene References
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0039094 DroID - A comprehensive database of gene and protein interactions. • FBgn0039094 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42783
Orthologs
OrthoDB Orthologs (41) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6S1TT7 Dipteran inclusive ortholog search EOG64BB9Z Insect inclusive ortholog search EOG6T4BRB Arthropod inclusive ortholog search EOG68W9HT Metazoa inclusive ortholog search EOG67MDRM
Orthologs in Drosophila Species (EOG6S1TT7)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG10184     Drosophila simulans   Dsim\GD18368 Y   Drosophila sechellia   Dsec\GM23553 Y   Drosophila erecta   Dere\GG12420 Y   Drosophila yakuba   Dyak\GE23939 Y   Drosophila ananassae   Dana\GF18752 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA10138 Y   Drosophila persimilis   Dper\GL13839 Y   Drosophila willistoni   Dwil\GK21059     Drosophila willistoni   Dwil\GK13412 Y   Drosophila virilis   Dvir\GJ23119 Y   Drosophila mojavensis   Dmoj\GI10703 Y   Drosophila grimshawi   Dgri\GH19068 Y
Orthologs in non-Drosophila Dipterans (EOG64BB9Z)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL005819   Anopheles gambiae Malaria mosquito  Agam\AGAP003688   Anopheles gambiae Malaria mosquito  Agam\AGAP013274   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ012034
Orthologs in non-Dipteran Insects (EOG6T4BRB)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB51675   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG008887   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH18484   Atta cephalotes Leafcutter ant  Acep\ACEP10360   Atta cephalotes Leafcutter ant  Acep\ACEP10361   Camponotus floridanus Florida carpenter ant  Cflo\CFLO23415   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL22315   Linepithema humile Argentine ant  Lhum\LH10780   Pogonomyrmex barbatus Red harvester ant  Pbar\PB24014   Acyrthosiphon pisum Pea aphid  Apim\ACYPI002421   Acyrthosiphon pisum Pea aphid  Apim\ACYPI000540   Bombyx mori Silkmoth  Bmor\BGIBMGA005681   Pediculus humanus Human body louse  Phum\PHUM423170   Tribolium castaneum Red flour beetle  Tcas\TC014583   Tribolium castaneum Red flour beetle  Tcas\TC006461   Tribolium castaneum Red flour beetle  Tcas\GLEAN_15250
Orthologs in non-Insect Arthropods (EOG68W9HT)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Atg12   Ixodes scapularis Deer tick  Isca\ISCW008580   Ixodes scapularis Deer tick  Isca\ISCW015447
Orthologs in non-Arthropod Metazoa (EOG67MDRM)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\R102.4   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_008871gn   Danio rerio Zebrafish  Drer\tha1   Xenopus tropicalis Western clawed frog  Xtro\tha1p   Mus musculus House mouse  Mmus\Tha1
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD18368 Drosophila sechellia Dsec\GM23553 Drosophila erecta Dere\GG12420 Drosophila yakuba Dyak\GE23939 Drosophila ananassae Dana\GF18752 Drosophila pseudoobscura pseudoobscura Dpse\GA10138 Drosophila persimilis Dper\GL13839 Drosophila willistoni Dwil\GK13412 Drosophila virilis Dvir\GJ23119 Drosophila mojavensis Dmoj\GI10703 Drosophila grimshawi Dgri\GH19068
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
VDRC	v104488 P{KK109320}VIE-260B v3311 w1118; P{GD1182}v3311/CyO
Genomic Clones ( 1 )
	BACR24C15 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 9 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD34157
Other clones	DPiM_LD34157
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE52759 SD09412
Other clones	106647 176891 DMG6-chr3R.34.004.pred.a EK281716 RP001047543
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0039094 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42783
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days. (Claridge-Chang et al., 2001)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_142904 RefSeq (Proteins) • NP_651161 DDBJ / EMBL / GenBank • AA979541 AAF56152 AAK93261 AW943216 AY051837 Entrez Gene - A searchable database of RefSeq genes. • 42783 UniProtKB/TrEMBL • Q9VCK6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Aromatic amino acid beta-eliminating lyase/threonine aldolase (IPR001597) Threonine aldolase (IPR023603) Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (IPR015421) Pyridoxal phosphate-dependent transferase, major region, subdomain 2 (IPR015422) Pyridoxal phosphate-dependent transferase (IPR015424)
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0039094 DroID - A comprehensive database of gene and protein interactions. • FBgn0039094 DRSC - Results from RNAi screens. • FBgn0039094 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039094 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10184-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0039094 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42783 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42783 modMine - Data generated by the modENCODE project. • FBgn0039094
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG10184 (Bartkuhn et al., 2009, Keleman et al., 2009.8.5)
Name Synonym
Secondary FlyBase IDs
References ( 15 )
Research paper	Bartkuhn et al., 2009, EMBO J. 28(7): 877--888 Active promoters and insulators are marked by the centrosomal protein 190. [FBrf0207850] Claridge-Chang et al., 2001, Neuron 32(4): 657--671 Circadian regulation of gene expression systems in the Drosophila head. [FBrf0141689]
Supplementary material	Guruharsha et al., 2011, Cell 147(3): Table S3. [FBrf0218395] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Mintseris et al., 2009.11.23, DPiM: the Drosophila Protein Interaction Mapping project DPiM: the Drosophila Protein Interaction Mapping project [FBrf0209452] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335] Gene Disruption Project members, 2001-, (Computer file) (Computer file) [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]
FlyBase analysis	FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]
Curated genome annotation	Lei, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126680]