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Gene Dmel\RanBP3

General Information
Symbol	Dmel\RanBP3	Species	D. melanogaster
Name	Ran binding protein 3	Annotation symbol	CG10225
Feature type	protein_coding_gene	FlyBase ID	FBgn0039110
Gene Model Status	Current	Stock availability	6 publicly available
Also Known As	RanBP3
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	95B1-95B1	Sequence location	3R:19,576,659..19,578,552 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Ran binding protein 3 is referred to in FlyBase by the symbol Dmel\RanBP3 (CG10225, FBgn0039110). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: nuclear export; negative regulation of Wnt receptor signaling pathway. 7 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Pleckstrin homology-type; Ran binding protein 1. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1635385_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of RanBP3. Gene sequence location is 3R:19576659..19578552.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Sequence features HFA14217 BKN45835 BKN28741
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 95B1-95B1   Limits computationally determined from genome sequence between P{PZ}l(3)0690606906 and P{PZ}l(3)0468404684
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\RanBP3 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) RanBP3-RA FBtr0084468  NM_142921   1766   449
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein RanBP3-PA   FBpp0083859   47.5   449   4.22     NP_651178   AAF56176
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ran binding protein 1 (IPR000156) Pleckstrin homology-type (IPR011993)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202726   AA539843   AA695397   AE014297 AAF56176   AW942032   AY069314 AAL39459   BF487026   BF496236   BG633598   BH900999   BI163565   BI215276   BI362855   BI369000   BI590435   BI641583   CK662156   CL844336   CO156314   CO178917   CO270059   CO272891   CO292081   CO293179   CO313023   CO338105   CZ474983   EC058365   EC079932   EC086714   EC197932   EC208670   EC209874   EC225551   EC235533   EC235664   EC262118   EC267095   FE862618   FE862635   FE862653   FE862659   FE862717   FE863176   FE863207   FE863272   GH740671   GH740799   GH741161   GH741689   GH742610   GH745035   GH745813   GH746031   GH747084   GH762194   GH763335   GH765248   GH766107   GH767476   GH769518   GH779400   GO254583
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VCI7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0039110    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0039110 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0039110 expression level Developmental Stage   Expression Level embryo 00-02hr    13874 embryo 02-04hr    9370 embryo 04-06hr    9201 embryo 06-08hr    8167 embryo 08-10hr    6141 embryo 10-12hr    5934 embryo 12-14hr    2385 embryo 14-16hr    2569 embryo 16-18hr    1573 embryo 18-20hr    1523 embryo 20-22hr    1316 embryo 22-24hr    1068 larva L1    2068 larva L2    2263 larva L3 12hr old    1995 larva L3 puffstage 1-2    2185 larva L3 puffstage 3-6    3591 larva L3 puffstage 7-9    3618 white prepupae new    3793 white prepupae 12hr    5151 white prepupae 24hr    5338 pupae 2d postWPP    3680 pupae 3d postWPP    2487 pupae 4d postWPP    3641 adult male 01day    3736 adult male 05day    5289 adult male 30day    4933 adult female 01day    4439 adult female 05day    6828 adult female 30day    7474 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (13874) embryo 02-04hr  (9370) embryo 04-06hr  (9201) embryo 06-08hr  (8167) embryo 08-10hr  (6141) embryo 10-12hr  (5934) embryo 12-14hr  (2385) embryo 14-16hr  (2569) embryo 16-18hr  (1573) embryo 18-20hr  (1523) embryo 20-22hr  (1316) embryo 22-24hr  (1068) larva L1  (2068) larva L2  (2263) larva L3 12hr old  (1995) larva L3 puffstage 1-2  (2185) larva L3 puffstage 3-6  (3591) larva L3 puffstage 7-9  (3618) white prepupae new  (3793) white prepupae 12hr  (5151) white prepupae 24hr  (5338) pupae 2d postWPP  (3680) pupae 3d postWPP  (2487) pupae 4d postWPP  (3641) adult male 01day  (3736) adult male 05day  (5289) adult male 30day  (4933) adult female 01day  (4439) adult female 05day  (6828) adult female 30day  (7474) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (13874) embryo 02-04hr  (9370) embryo 04-06hr  (9201) embryo 06-08hr  (8167) embryo 08-10hr  (6141) embryo 10-12hr  (5934) embryo 12-14hr  (2385) embryo 14-16hr  (2569) embryo 16-18hr  (1573) embryo 18-20hr  (1523) embryo 20-22hr    1316 embryo 22-24hr    1068 larva L1  (2068) larva L2  (2263) larva L3 12hr old  (1995) larva L3 puffstage 1-2  (2185) larva L3 puffstage 3-6  (3591) larva L3 puffstage 7-9  (3618) white prepupae new  (3793) white prepupae 12hr  (5151) white prepupae 24hr  (5338) pupae 2d postWPP  (3680) pupae 3d postWPP  (2487) pupae 4d postWPP  (3641) adult male 01day  (3736) adult male 05day  (5289) adult male 30day  (4933) adult female 01day  (4439) adult female 05day  (6828) adult female 30day  (7474) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (13874) embryo 02-04hr    9370 embryo 04-06hr    9201 embryo 06-08hr    8167 embryo 08-10hr    6141 embryo 10-12hr    5934 embryo 12-14hr    2385 embryo 14-16hr    2569 embryo 16-18hr    1573 embryo 18-20hr    1523 embryo 20-22hr    1316 embryo 22-24hr    1068 larva L1    2068 larva L2    2263 larva L3 12hr old    1995 larva L3 puffstage 1-2    2185 larva L3 puffstage 3-6    3591 larva L3 puffstage 7-9    3618 white prepupae new    3793 white prepupae 12hr    5151 white prepupae 24hr    5338 pupae 2d postWPP    3680 pupae 3d postWPP    2487 pupae 4d postWPP    3641 adult male 01day    3736 adult male 05day    5289 adult male 30day    4933 adult female 01day    4439 adult female 05day    6828 adult female 30day    7474 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    13874 embryo 02-04hr    9370 embryo 04-06hr    9201 embryo 06-08hr    8167 embryo 08-10hr    6141 embryo 10-12hr    5934 embryo 12-14hr    2385 embryo 14-16hr    2569 embryo 16-18hr    1573 embryo 18-20hr    1523 embryo 20-22hr    1316 embryo 22-24hr    1068 larva L1    2068 larva L2    2263 larva L3 12hr old    1995 larva L3 puffstage 1-2    2185 larva L3 puffstage 3-6    3591 larva L3 puffstage 7-9    3618 white prepupae new    3793 white prepupae 12hr    5151 white prepupae 24hr    5338 pupae 2d postWPP    3680 pupae 3d postWPP    2487 pupae 4d postWPP    3641 adult male 01day    3736 adult male 05day    5289 adult male 30day    4933 adult female 01day    4439 adult female 05day    6828 adult female 30day    7474 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0039110 expression level Developmental Stage   Expression Level embryo 00-02hr    13874 embryo 02-04hr    9370 embryo 04-06hr    9201 embryo 06-08hr    8167 embryo 08-10hr    6141 embryo 10-12hr    5934 embryo 12-14hr    2385 embryo 14-16hr    2569 embryo 16-18hr    1573 embryo 18-20hr    1523 embryo 20-22hr    1316 embryo 22-24hr    1068 larva L1    2068 larva L2    2263 larva L3 12hr old    1995 larva L3 puffstage 1-2    2185 larva L3 puffstage 3-6    3591 larva L3 puffstage 7-9    3618 white prepupae new    3793 white prepupae 12hr    5151 white prepupae 24hr    5338 pupae 2d postWPP    3680 pupae 3d postWPP    2487 pupae 4d postWPP    3641 adult male 01day    3736 adult male 05day    5289 adult male 30day    4933 adult female 01day    4439 adult female 05day    6828 adult female 30day    7474 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (13874) embryo 02-04hr  (9370) embryo 04-06hr  (9201) embryo 06-08hr  (8167) embryo 08-10hr  (6141) embryo 10-12hr  (5934) embryo 12-14hr  (2385) embryo 14-16hr  (2569) embryo 16-18hr  (1573) embryo 18-20hr  (1523) embryo 20-22hr  (1316) embryo 22-24hr  (1068) larva L1  (2068) larva L2  (2263) larva L3 12hr old  (1995) larva L3 puffstage 1-2  (2185) larva L3 puffstage 3-6  (3591) larva L3 puffstage 7-9  (3618) white prepupae new  (3793) white prepupae 12hr  (5151) white prepupae 24hr  (5338) pupae 2d postWPP  (3680) pupae 3d postWPP  (2487) pupae 4d postWPP  (3641) adult male 01day  (3736) adult male 05day  (5289) adult male 30day  (4933) adult female 01day  (4439) adult female 05day  (6828) adult female 30day  (7474) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (13874) embryo 02-04hr  (9370) embryo 04-06hr  (9201) embryo 06-08hr  (8167) embryo 08-10hr  (6141) embryo 10-12hr  (5934) embryo 12-14hr  2385 embryo 14-16hr  (2569) embryo 16-18hr  1573 embryo 18-20hr  1523 embryo 20-22hr    1316 embryo 22-24hr    1068 larva L1  2068 larva L2  2263 larva L3 12hr old  1995 larva L3 puffstage 1-2  2185 larva L3 puffstage 3-6  (3591) larva L3 puffstage 7-9  (3618) white prepupae new  (3793) white prepupae 12hr  (5151) white prepupae 24hr  (5338) pupae 2d postWPP  (3680) pupae 3d postWPP  (2487) pupae 4d postWPP  (3641) adult male 01day  (3736) adult male 05day  (5289) adult male 30day  (4933) adult female 01day  (4439) adult female 05day  (6828) adult female 30day  (7474) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  13874 embryo 02-04hr    9370 embryo 04-06hr    9201 embryo 06-08hr    8167 embryo 08-10hr    6141 embryo 10-12hr    5934 embryo 12-14hr    2385 embryo 14-16hr    2569 embryo 16-18hr    1573 embryo 18-20hr    1523 embryo 20-22hr    1316 embryo 22-24hr    1068 larva L1    2068 larva L2    2263 larva L3 12hr old    1995 larva L3 puffstage 1-2    2185 larva L3 puffstage 3-6    3591 larva L3 puffstage 7-9    3618 white prepupae new    3793 white prepupae 12hr    5151 white prepupae 24hr    5338 pupae 2d postWPP    3680 pupae 3d postWPP    2487 pupae 4d postWPP    3641 adult male 01day    3736 adult male 05day    5289 adult male 30day    4933 adult female 01day    4439 adult female 05day    6828 adult female 30day    7474 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    13874 embryo 02-04hr    9370 embryo 04-06hr    9201 embryo 06-08hr    8167 embryo 08-10hr    6141 embryo 10-12hr    5934 embryo 12-14hr    2385 embryo 14-16hr    2569 embryo 16-18hr    1573 embryo 18-20hr    1523 embryo 20-22hr    1316 embryo 22-24hr    1068 larva L1    2068 larva L2    2263 larva L3 12hr old    1995 larva L3 puffstage 1-2    2185 larva L3 puffstage 3-6    3591 larva L3 puffstage 7-9    3618 white prepupae new    3793 white prepupae 12hr    5151 white prepupae 24hr    5338 pupae 2d postWPP    3680 pupae 3d postWPP    2487 pupae 4d postWPP    3641 adult male 01day    3736 adult male 05day    5289 adult male 30day    4933 adult female 01day    4439 adult female 05day    6828 adult female 30day    7474 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0039110    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0039110 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0039110 expression level Tissue   Expression Level Larval Central Nervous System    457.55 Larval Midgut    129.3 Larval Hindgut    218.8 Larval Malpighian Tubules    295.6 Larval Fat Body    204.7 Larval Salivary Gland    330.2 Larval Trachea    440.375 Larval Carcass    312.2 Adult Head    143.1 Adult Eye    201.925 Adult Brain    194.8 Adult Thoracic-Abdominal Ganglion    213.1 Adult Crop    172.3 Adult Midgut    112.4 Adult Hindgut    218.8 Adult Malpighian Tubules    149.1 Adult Fat Body    132.1 Adult Salivary Gland    213.1 Adult Heart    149.125 Adult VirginFemale Spermatheca    155.2 Adult InseminatedFemale Spermatheca    165.2 Adult Ovary    578.7 Adult Testis    445.9 Adult Male Accessory Gland    182.7 Adult Carcass    161.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    457.55 Larval Midgut    129.3 Larval Hindgut    218.8 Larval Malpighian Tubules    295.6 Larval Fat Body    204.7 Larval Salivary Gland    330.2 Larval Trachea    440.375 Larval Carcass    312.2 Adult Head    143.1 Adult Eye    201.925 Adult Brain    194.8 Adult Thoracic-Abdominal Ganglion    213.1 Adult Crop    172.3 Adult Midgut    112.4 Adult Hindgut    218.8 Adult Malpighian Tubules    149.1 Adult Fat Body    132.1 Adult Salivary Gland    213.1 Adult Heart    149.125 Adult VirginFemale Spermatheca    155.2 Adult InseminatedFemale Spermatheca    165.2 Adult Ovary  (578.7) Adult Testis    445.9 Adult Male Accessory Gland    182.7 Adult Carcass    161.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    457.55 Larval Midgut    129.3 Larval Hindgut    218.8 Larval Malpighian Tubules    295.6 Larval Fat Body    204.7 Larval Salivary Gland    330.2 Larval Trachea    440.375 Larval Carcass    312.2 Adult Head    143.1 Adult Eye    201.925 Adult Brain    194.8 Adult Thoracic-Abdominal Ganglion    213.1 Adult Crop    172.3 Adult Midgut    112.4 Adult Hindgut    218.8 Adult Malpighian Tubules    149.1 Adult Fat Body    132.1 Adult Salivary Gland    213.1 Adult Heart    149.125 Adult VirginFemale Spermatheca    155.2 Adult InseminatedFemale Spermatheca    165.2 Adult Ovary    578.7 Adult Testis    445.9 Adult Male Accessory Gland    182.7 Adult Carcass    161.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    457.55 Larval Midgut    129.3 Larval Hindgut    218.8 Larval Malpighian Tubules    295.6 Larval Fat Body    204.7 Larval Salivary Gland    330.2 Larval Trachea    440.375 Larval Carcass    312.2 Adult Head    143.1 Adult Eye    201.925 Adult Brain    194.8 Adult Thoracic-Abdominal Ganglion    213.1 Adult Crop    172.3 Adult Midgut    112.4 Adult Hindgut    218.8 Adult Malpighian Tubules    149.1 Adult Fat Body    132.1 Adult Salivary Gland    213.1 Adult Heart    149.125 Adult VirginFemale Spermatheca    155.2 Adult InseminatedFemale Spermatheca    165.2 Adult Ovary    578.7 Adult Testis    445.9 Adult Male Accessory Gland    182.7 Adult Carcass    161.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0039110 expression level Tissue   Expression Level Larval Central Nervous System    457.55 Larval Midgut    129.3 Larval Hindgut    218.8 Larval Malpighian Tubules    295.6 Larval Fat Body    204.7 Larval Salivary Gland    330.2 Larval Trachea    440.375 Larval Carcass    312.2 Adult Head    143.1 Adult Eye    201.925 Adult Brain    194.8 Adult Thoracic-Abdominal Ganglion    213.1 Adult Crop    172.3 Adult Midgut    112.4 Adult Hindgut    218.8 Adult Malpighian Tubules    149.1 Adult Fat Body    132.1 Adult Salivary Gland    213.1 Adult Heart    149.125 Adult VirginFemale Spermatheca    155.2 Adult InseminatedFemale Spermatheca    165.2 Adult Ovary    578.7 Adult Testis    445.9 Adult Male Accessory Gland    182.7 Adult Carcass    161.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    457.55 Larval Midgut    129.3 Larval Hindgut    218.8 Larval Malpighian Tubules    295.6 Larval Fat Body    204.7 Larval Salivary Gland    330.2 Larval Trachea    440.375 Larval Carcass    312.2 Adult Head    143.1 Adult Eye    201.925 Adult Brain    194.8 Adult Thoracic-Abdominal Ganglion    213.1 Adult Crop    172.3 Adult Midgut    112.4 Adult Hindgut    218.8 Adult Malpighian Tubules    149.1 Adult Fat Body    132.1 Adult Salivary Gland    213.1 Adult Heart    149.125 Adult VirginFemale Spermatheca    155.2 Adult InseminatedFemale Spermatheca    165.2 Adult Ovary  578.7 Adult Testis    445.9 Adult Male Accessory Gland    182.7 Adult Carcass    161.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    457.55 Larval Midgut    129.3 Larval Hindgut    218.8 Larval Malpighian Tubules    295.6 Larval Fat Body    204.7 Larval Salivary Gland    330.2 Larval Trachea    440.375 Larval Carcass    312.2 Adult Head    143.1 Adult Eye    201.925 Adult Brain    194.8 Adult Thoracic-Abdominal Ganglion    213.1 Adult Crop    172.3 Adult Midgut    112.4 Adult Hindgut    218.8 Adult Malpighian Tubules    149.1 Adult Fat Body    132.1 Adult Salivary Gland    213.1 Adult Heart    149.125 Adult VirginFemale Spermatheca    155.2 Adult InseminatedFemale Spermatheca    165.2 Adult Ovary    578.7 Adult Testis    445.9 Adult Male Accessory Gland    182.7 Adult Carcass    161.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    457.55 Larval Midgut    129.3 Larval Hindgut    218.8 Larval Malpighian Tubules    295.6 Larval Fat Body    204.7 Larval Salivary Gland    330.2 Larval Trachea    440.375 Larval Carcass    312.2 Adult Head    143.1 Adult Eye    201.925 Adult Brain    194.8 Adult Thoracic-Abdominal Ganglion    213.1 Adult Crop    172.3 Adult Midgut    112.4 Adult Hindgut    218.8 Adult Malpighian Tubules    149.1 Adult Fat Body    132.1 Adult Salivary Gland    213.1 Adult Heart    149.125 Adult VirginFemale Spermatheca    155.2 Adult InseminatedFemale Spermatheca    165.2 Adult Ovary    578.7 Adult Testis    445.9 Adult Male Accessory Gland    182.7 Adult Carcass    161.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    143.1   NA  Eye    201.925   NA  Brain    194.8   457.55  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    213.1   NA  Crop    172.3   129.3  Midgut    112.4   218.8  Hindgut    218.8   295.6  Malpighian Tubules    149.1   204.7  Fat Body    132.1   330.2  Salivary Gland    213.1   NA  Heart    149.125   440.375  Trachea    NA   NA  VirginFemale Spermatheca    155.2   NA  InseminatedFemale Spermatheca    165.2   NA  Ovary    578.7   NA  Testis    445.9   NA  Male Accessory Gland    182.7   312.2  Carcass    161.8 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_06
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039110 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10225-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable RanBP3EY10605 viable, with Scer\GAL4pnr-MD237 RanBP3GD6906 Sterility Allele fertile RanBP3EY10605 Phenotype manifest in Allele
Classical Alleles ( 5 )
For All Classical Alleles Show
Allele of RanBP3 Class Mutagen Stocks Known lesion RanBP3d06200 P-element activity 1 -- RanBP3DG19608 P-element activity 1 -- RanBP3EY10605 P-element activity 1 -- RanBP3KG08193 P-element activity 1 -- RanBP3CB02343 0 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of RanBP3 Class Mutagen Stocks Known lesion RanBP3GD6906 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes RanBP3KK108741 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel9013 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}RanBP3EY10605 NA P{XP}RanBP3d06200 NA miscellaneous insertions P{PTT-GB}RanBP3CB02343 NA P{SUPor-P}RanBP3KG08193 NA P{wHy}RanBP3DG19608 NA
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
negative regulation of Wnt receptor signaling pathway inferred from direct assay (Hendriksen et al., 2005) nuclear export inferred from mutant phenotype (Sabri et al., 2007)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions RanBP3 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67742 DroID - A comprehensive database of gene and protein interactions. • FBgn0039110 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42804
Orthologs
Genome-wide drosophilid orthologs	Dana\GF18744 Dere\GG12410 Dgri\GH11730 Dmoj\GI22401 Dper\GL24276 Dpse\GA10170 Dsec\GM23544 Dsim\GD18358 Dvir\GJ24650 Dwil\GK10849 Dyak\GE23929
Curated drosophilid orthologs	Dpse\GA10170
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL014529-PA Aedes aegypti (mosquito) AGAP004520-PA Anopheles gambiae (mosquito) XP_001120684.1 Apis mellifera (honey bee) XP_001950334.1 Acyrthosiphon pisum (pea aphid) At3g15970.1 Arabidopsis thaliana (wall cress) 130833 Branchiostoma floridae (lancelet) XP_001892167.1 Brugia malayi (roundworm nematode) BGIBMGA004672-PA Bombyx mori (silk worm) ENSBTAP00000042039 Bos taurus (bovine) CAL0005996 Candida albicans (a form of yeast) CN00133 Caenorhabditis brenneri (small nematode) CN23117 Caenorhabditis brenneri (small nematode) CE02847 Caenorhabditis elegans (worm) ENSCAFP00000027650 Canis familiaris (dog) CAGL0M12617g Candida glabrata (haploid yeast) ENSCINP00000015453 Ciona intestinalis (sea squirt) CPIJ008315 Culex pipens (mosquito) ENSCPOP00000018821 Cavia porcellus (guinea pig) RP42787 Caenorhabditis remanei (nematode) ENSCSAVP00000002196 Ciona savignyi (sedentary tunicate) DDB0205337 Dictyostelium discoideum (amoeba) 318238 Daphnia pulex (daphnia) ENSDARP00000090948 Danio rerio (zebra fish) ENSECAP00000022359 Equus caballus (horse) ENSGACP00000022229 Gymnopilus aculeatus (mushroom) ENSGALP00000000805 Gallus gallus (chicken) ENSP00000341483 Homo sapiens (human) ISCW010229-PA Ixodes scapularis (deer tick) ENSMODP00000001661 Monodelphis domestica (gray opossum) ENSMMUP00000015687 Macaca mulatta (rhesus monkey) ENSMUSP00000002445 Mus musculus (house mouse) XP_001607745.1 Nasonia vitripennis (wasp) ENSOANP00000007848 Ornithorynchus anatinus (platypus) ENSORLP00000022593 Oryzias latipes (japanese killifish) LOC_Os05g28190.1 Oryza sativa (asian rice) PHUM010624-PA Pediculus humanus (human body louse) ENSPPYP00000010590 Pongo pygmaeus (orangutan) 797471 Populus trichocarpa (black cottonwood) ENSPTRP00000017608 Pan troglodytes (chimpanzee) ENSRNOP00000039309 Rattus norvegicus (norway rat) 4893975 Sorghum bicolor (sorghum) YIL063C Saccharomyces cerevisiae (budding yeast) SPBC365.13c Schizosaccharomyces pombe (fission yeast) XP_796334.2 Strongylocentrotus purpuratus (purple sea urchin) 58839 Trichoplax adhaerens (metazoa) XP_970620.1 Tribolium castaneum (red flour beetle) ENSTNIP00000017933 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000028596 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000025122 Xenopus tropicalis (frog) YALI0E10901g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB18655 NV10338 LH11552 ISCW010229 FBgn0241074 FBgn0212860 FBgn0211727 FBgn0189886 FBgn0178410 JGI_V11_318238 FBgn0070229 FBgn0161866 FBgn0145129 FBgn0119210 FBgn0104698 FBgn0095761 BGIBMGA004672 ACYPI006600 GB12739 AGAP004520 AAEL014529 PHUM521120 GLEAN_12664
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	20192 y1 w67c23; P{EPgy2}RanBP3EY10605 14695 y1 w67c23; ry506 P{SUPor-P}RanBP3KG08193 21697 y1 w67c23; P{wHy}RanBP3DG19608 P{wHy}Tbp-1DG19608
Harvard	- P{XP}RanBP3d06200
VDRC	v104432 P{KK108741}VIE-260B v38363 w1118; P{GD6906}v38363
Genomic Clones ( 2 )
	BACR11E07 BACR16I18 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 56 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD02979
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT09987 AT21687 LD19117 LP22162 RE02989 RE21635 RE47529 RE55073 RH04057 SD24980
Other clones	9373 15294 71275 73020 73905 105712 527720 569956 CK01.7C.E10 CK01.73C.C6 CK01.126D.G10 EK057943 EK097257 EK108662 EK199139 EK202015 EK230945 EN07827 EN15950 GM02752 RM05182 RM05382 RM05582 RM05682 RM05982 RM06282 RM06382 RM06482 RP01018 RP001000407 RP001008711 RP001020028 RP001028054 RP001030528 RP001031305 RP001035178 RP001036635 RP001036878 RP001039328 RP001039528 RP001039961 RP001042015 RP001043077 RP001045648 RP001046406
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0039110 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42804
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: RanBP3 CG10225 (Hendriksen et al., 2005)
Source for database merge of
Additional comments
Other Comments
	S2 cells treated with dsRNA against CG10225 display a significant increase in phospho-Stat92E nuclear accumulation upon os stimulation. (Baeg et al., 2005) S2-derived S2-NP cells are treated with dsRNA made from templates generated with primers directed against CG10225 to assess the role of this gene in Stat92E tyrosine phosphorylation. (Baeg et al., 2005) Injection into embryos of dsRNA made from templates generated with primers directed against this gene causes a partial or complete transformation of denticles into naked cuticle in ~14% of the embryos. The most severe phenotypes exhibit deformation of both the head and spiracles. Almost all injected embryos exhibiting a strong naked cuticle phenotype are shorter than wild-type. (Hendriksen et al., 2005)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_142921 RefSeq (Proteins) • NP_651178 DDBJ / EMBL / GenBank • AA202726 AAF56176 AAL39459 AW942032 AY069314 BH900999 CL844336 CZ474983 Entrez Gene - A searchable database of RefSeq genes. • 42804 UniProtKB/TrEMBL • Q9VCI7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ran binding protein 1 (IPR000156) Pleckstrin homology-type (IPR011993)
Linkouts
	BioGRID - A database of protein and genetic interactions • 67742 DroID - A comprehensive database of gene and protein interactions. • FBgn0039110 DRSC - Results from RNAi screens. • FBgn0039110 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039110 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10225-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0039110 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42804 InParanoid A subset of ortholog calls from InParanoid. • AAEL014529-PA Aedes aegypti (mosquito) AGAP004520-PA Anopheles gambiae (mosquito) XP_001120684.1 Apis mellifera (honey bee) XP_001950334.1 Acyrthosiphon pisum (pea aphid) At3g15970.1 Arabidopsis thaliana (wall cress) 130833 Branchiostoma floridae (lancelet) XP_001892167.1 Brugia malayi (roundworm nematode) BGIBMGA004672-PA Bombyx mori (silk worm) ENSBTAP00000042039 Bos taurus (bovine) CAL0005996 Candida albicans (a form of yeast) CN00133 Caenorhabditis brenneri (small nematode) CN23117 Caenorhabditis brenneri (small nematode) CE02847 Caenorhabditis elegans (worm) ENSCAFP00000027650 Canis familiaris (dog) CAGL0M12617g Candida glabrata (haploid yeast) ENSCINP00000015453 Ciona intestinalis (sea squirt) CPIJ008315 Culex pipens (mosquito) ENSCPOP00000018821 Cavia porcellus (guinea pig) RP42787 Caenorhabditis remanei (nematode) ENSCSAVP00000002196 Ciona savignyi (sedentary tunicate) DDB0205337 Dictyostelium discoideum (amoeba) 318238 Daphnia pulex (daphnia) ENSDARP00000090948 Danio rerio (zebra fish) ENSECAP00000022359 Equus caballus (horse) ENSGACP00000022229 Gymnopilus aculeatus (mushroom) ENSGALP00000000805 Gallus gallus (chicken) ENSP00000341483 Homo sapiens (human) ISCW010229-PA Ixodes scapularis (deer tick) ENSMODP00000001661 Monodelphis domestica (gray opossum) ENSMMUP00000015687 Macaca mulatta (rhesus monkey) ENSMUSP00000002445 Mus musculus (house mouse) XP_001607745.1 Nasonia vitripennis (wasp) ENSOANP00000007848 Ornithorynchus anatinus (platypus) ENSORLP00000022593 Oryzias latipes (japanese killifish) LOC_Os05g28190.1 Oryza sativa (asian rice) PHUM010624-PA Pediculus humanus (human body louse) ENSPPYP00000010590 Pongo pygmaeus (orangutan) 797471 Populus trichocarpa (black cottonwood) ENSPTRP00000017608 Pan troglodytes (chimpanzee) ENSRNOP00000039309 Rattus norvegicus (norway rat) 4893975 Sorghum bicolor (sorghum) YIL063C Saccharomyces cerevisiae (budding yeast) SPBC365.13c Schizosaccharomyces pombe (fission yeast) XP_796334.2 Strongylocentrotus purpuratus (purple sea urchin) 58839 Trichoplax adhaerens (metazoa) XP_970620.1 Tribolium castaneum (red flour beetle) ENSTNIP00000017933 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000028596 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000025122 Xenopus tropicalis (frog) YALI0E10901g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42804 modMine - Data generated by the modENCODE project. • FBgn0039110 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB18655 NV10338 LH11552 ISCW010229 FBgn0241074 FBgn0212860 FBgn0211727 FBgn0189886 FBgn0178410 JGI_V11_318238 FBgn0070229 FBgn0161866 FBgn0145129 FBgn0119210 FBgn0104698 FBgn0095761 BGIBMGA004672 ACYPI006600 GB12739 AGAP004520 AAEL014529 PHUM521120 GLEAN_12664
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	CG10225 (Buszczak et al., 2007, Liu et al., 2009, Keleman et al., 2009.8.5) GC10225 (Hendriksen et al., 2005) RanBP3 (Hendriksen et al., 2005, Sabri et al., 2007, )
Name Synonym	Ran binding protein 3 (Hendriksen et al., 2005, )
Secondary FlyBase IDs
References ( 18 )
Research paper	Liu et al., 2009, Science 323(5918): 1218--1222 Analysis of Drosophila segmentation network identifies a JNK pathway factor overexpressed in kidney cancer. [FBrf0207535] Buszczak et al., 2007, Genetics 175(3): 1505--1531 The Carnegie protein trap library: A versatile tool for Drosophila developmental studies. [FBrf0200345] Sabri et al., 2007, J. Cell Biol. 178(4): 557--565 Distinct functions of the Drosophila Nup153 and Nup214 FG domains in nuclear protein transport. [FBrf0201308] Baeg et al., 2005, Genes Dev. 19(16): 1861--1870 Genome-wide RNAi analysis of JAK/STAT signaling components in Drosophila. [FBrf0187589] Hendriksen et al., 2005, J. Cell Biol. 171(5): 785--797 RanBP3 enhances nuclear export of active beta-catenin independently of CRM1. [FBrf0190935]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Gelbart, 2008.3.31, DG.xml DG.xml [FBrf0204101] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
FlyBase analysis	FlyBase Curators, 2008, Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. [FBrf0202955] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. Genomic mapping of Exelixis insertion collection. [FBrf0184340] Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]