FlyBase Gene Report: Dmel\Lsd-1

General Information

Symbol

Dmel\Lsd-1

Species

D. melanogaster

Name

Lipid storage droplet-1

Annotation Symbol

CG10374

Feature Type

protein_coding_gene

FlyBase ID

FBgn0039114

Gene Model Status

Current

Stock Availability

7 publicly available

Gene Summary

Lipid storage droplet-1 (Lsd-1) encodes a protein associated with lipid droplets. It protects lipid droplets from lipase mediated remobilization and facilitates lipolysis by serving as an anchoring point for lipases such as the one encoded by Hsl. It is involved in lipid storage amount regulation and energy homeostasis in concert with the product of Lsd-2. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
UniProtKB
Interactive Fly

Also Known As

Lsd1, plin1, lipid storage droplet protein 1, Lsdp1

Key Links

Genomic Location

Cytogenetic map

95B1-95B1

Sequence location

3R:23,763,857..23,766,662 [+]

Recombination map

3-80

RefSeq locus

NT_033777 REGION:23763857..23766662

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (11 terms)

Molecular Function (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (8 terms)

Terms Based on Experimental Evidence (7 terms)

CV Term

Evidence

References

involved_in lipid droplet organization

inferred from mutant phenotype

(Yao et al., 2018, Beller et al., 2010)

inferred from mutant phenotype

(Ugrankar et al., 2019)

involved_in lipid storage

inferred from expression pattern

(Miura et al., 2002)

involved_in lipid transport

inferred from expression pattern

(Miura et al., 2002)

involved_in positive regulation of triglyceride catabolic process

inferred from direct assay

(Arrese et al., 2008)

involved_in protein localization to lipid droplet

inferred from mutant phenotype

(Bi et al., 2012)

involved_in regulation of lipid storage

inferred from mutant phenotype

(Beller et al., 2010)

involved_in triglyceride mobilization

inferred from mutant phenotype

(Bi et al., 2012)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in lipid storage

inferred from biological aspect of ancestor with PANTHER:PTN004450669

(GO Reference Genome Project, 2011-)

involved_in positive regulation of triglyceride storage

inferred from biological aspect of ancestor with PANTHER:PTN004450669

(GO Reference Genome Project, 2011-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

is_active_in lipid droplet

inferred from direct assay

(Liu et al., 2024)

located_in lipid droplet

inferred from direct assay

(Bi et al., 2012, Beller et al., 2010, Miura et al., 2002)

part_of protein-lipid complex

inferred from direct assay

(Arrese et al., 2008)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in cytosol

inferred from biological aspect of ancestor with PANTHER:PTN004450669

(GO Reference Genome Project, 2011-)

is_active_in lipid droplet

inferred from biological aspect of ancestor with PANTHER:PTN004450669

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Protein Family (UniProt)

Belongs to the perilipin family. (Q9VCI3)

Protein Signatures (InterPro)

Perilipin

Summaries

Gene Snapshot

Protein Function (UniProtKB)

Required for normal deposition of neutral lipids in the oocyte.

(UniProt, Q9VCI3)

Summary (Interactive Fly)

intracellular neutral lipid droplet storage protein - maintains energy homeostasis

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Lsd-1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VCI3)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.47

Low-frequency RNA-Seq exon junction(s) not annotated.

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Lsd-1-RA

FBtr0084455

NM_170092

1510

431

Lsd-1-RB

FBtr0084457

NM_170093

1501

325

Lsd-1-RC

FBtr0084456

NM_142926

1813

405

Lsd-1-RD

FBtr0335002

NM_001275954

1432

405

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Lsd-1-PA

FBpp0083846

48.8

431

9.59

FBpp0083848

36.9

325

9.48

NP_732905

AAF56184

Lsd-1-PC

FBpp0083847

45.8

405

9.02

FBpp0307010

45.8

405

9.02

A0A0B4KHZ1

NP_001262883

AGB96263

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

405 aa isoforms: Lsd-1-PC, Lsd-1-PD

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Perilipin

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Lsd-1 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.85

Transcript Expression

No Assay Recorded

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 15 -- 17

corpus allatum

(Beller et al., 2010)

ring gland

(Beller et al., 2010)

embryonic/larval fat body

(Beller et al., 2010)

adult stage

adult fat body

(Beller et al., 2010)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 11 -- 12

amnioserosa

(Fisher et al., 2012)

yolk nucleus

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic/larval corpus allatum

(Fisher et al., 2012)

embryonic/larval fat body

(Fisher et al., 2012)

yolk nucleus

(Fisher et al., 2012)

Additional Descriptive Data

Lsd-1 transcripts are expressed in late embryonic stages in the corpus allatum cells of the developing ring glad and in fat body. Fat body expression continues in post-embryonic stages.

(Beller et al., 2010)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

No Assay Recorded

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 15 -- 17

fat body

(Beller et al., 2010)

adult stage

adult fat body

(Beller et al., 2010)

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

wing disc

(Binh et al., 2019)

wing pouch | intense

(Binh et al., 2019)

mesonotum | intense

(Binh et al., 2019)

wandering third instar larval stage

wing pouch

(Men et al., 2016)

wing disc | restricted

(Men et al., 2016)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

Additional Descriptive Data

Lsd-1 protein is observed in the wing pouch of the wing disc, and in other areas of the wing disc.

(Men et al., 2016)

Lsd-1 protein is detected from late embryonic stages in the fat body. It associates with the lipid droplet surface in fat body cells.

(Beller et al., 2010)

Marker for

Subcellular Localization

CV Term

Evidence

References

is_active_in lipid droplet

inferred from direct assay

(Liu et al., 2024)

located_in lipid droplet

inferred from direct assay

(Bi et al., 2012, Beller et al., 2010, Miura et al., 2002)

part_of protein-lipid complex

inferred from direct assay

(Arrese et al., 2008)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Lsd-1 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Lsd-1

View exonic expression by tissue for Dmel\Lsd-1

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0039114

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42810/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0039114

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0039114

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0039114

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG10374

Flygut - An atlas of the Drosophila adult midgut

FBgn0039114

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Lsd-1

Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 10 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 17 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Lsd-1

Transgenic constructs containing regulatory region of Lsd-1

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(3R)Exel9013

(Ryder, 2004.4.26)

Inferred from location ( 4 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^en.PU

Lsd-1^GD6641

lethal, with Scer\GAL4^insc-Mz1407

Lsd-1^GD6641

lethal | heat sensitive, with Scer\GAL4^fat

Lsd-1^GD6641

lethal - all die during embryonic stage, with Scer\GAL4^Act5C.PU

Lsd-1^GD6641

lethal - all die during embryonic stage, with Scer\GAL4^Tub.PU

Lsd-1^GD6641

lethal - all die during P-stage, with Scer\GAL4^Mef2.PR

Lsd-1^GD6641

partially lethal - majority die, with Scer\GAL4^pnr-MD237

Lsd-1^GD6641

viable, with Scer\GAL4^pnr-MD237

Lsd-1^GD16398

viable, with Scer\GAL4^tin.CΔ4

Lsd-1^GD6641

Other Phenotypes

Allele

abnormal developmental rate, with Scer\GAL4^fat

Lsd-1^GD6641

abnormal immune response | adult stage

Lsd-1³⁸

abnormal immune response | adult stage, with Scer\GAL4^ppl.PU

abnormal neuroanatomy | larval stage, with Scer\GAL4^insc-Mz1407

Lsd-1^GD6641

abnormal size | larval stage

Lsd-1³⁸

abnormal size | larval stage, with Scer\GAL4^ppl.PU

Lsd-1^HMC05894

abnormal starvation stress response | larval stage

Lsd-1³⁸

abnormal stress response

Lsd-1¹

abnormal stress response, with Scer\GAL4^fat

Lsd-1^RNAi.UAS.cBa

abnormal stress response (with Lsd-1¹)

Lsd-1²

abnormal stress response (with Lsd-1²)

Lsd-1¹

atrophy | adult stage, with Scer\GAL4^Bx-MS1096

Lsd-1^GD6641

increased body size

increased cell death | third instar larval stage, with Scer\GAL4^Bx-MS1096

Lsd-1^GD6641

increased size | adult stage, with Scer\GAL4^ppl.PP

Lsd-1^TH04820.N

long lived | conditional

Lsd-1³⁸

long lived | conditional, with Scer\GAL4^ppl.PU

Lsd-1^RNAi.UAS.cUa

short lived | conditional, with Scer\GAL4^ppl.PU

Lsd-1^UAS.mCherry

some die during pupal stage, with Scer\GAL4^pnr-MD237

Lsd-1^GD6641

visible, with Scer\GAL4^pnr-MD237

Lsd-1^GD6641

visible | adult stage, with Scer\GAL4^Bx-MS1096

Lsd-1^GD6641

Phenotype manifest in

Allele

adult fat body | adult stage

Lsd-1³⁸

adult fat body | adult stage, with Scer\GAL4^ppl.PU

adult fat body | adult stage | RU486 conditional, with Scer\GAL4^Switch1.106

embryonic/larval fat body | larval stage

embryonic/larval fat body | larval stage, with Scer\GAL4^ppl.PU

Lsd-1^HMC05894

fat cell | third instar larval stage, with Scer\GAL4^DcG

Lsd-1^HMC05894

ganglion mother cell | larval stage, with Scer\GAL4^insc-Mz1407

Lsd-1^GD6641

lipid droplet

lipid droplet, with Scer\GAL4^fat

Lsd-1^RNAi.UAS.cBa

lipid droplet | adult stage

Lsd-1³⁸

lipid droplet | adult stage, with Scer\GAL4^ppl.PP

Lsd-1^TH04820.N

lipid droplet | adult stage, with Scer\GAL4^ppl.PU

lipid droplet | adult stage | increased number, with Scer\GAL4^ninaE.PT

Lsd-1^UAS.EGFP

lipid droplet | adult stage | progressive

Lsd-1³⁸

lipid droplet | adult stage | RU486 conditional, with Scer\GAL4^Switch1.106

lipid droplet | larval stage

Lsd-1³⁸

lipid droplet | larval stage, with Scer\GAL4^ppl.PU

Lsd-1^HMC05894

lipid droplet | third instar larval stage, with Scer\GAL4^DcG

Lsd-1^HMC05894

mesonotum, with Scer\GAL4^pnr-MD237

Lsd-1^GD6641

mesothoracic tergotrochanter muscle cell | progressive

Lsd-1³⁸

mitochondrion | third instar larval stage, with Scer\GAL4^Bx-MS1096

Lsd-1^GD6641

photoreceptor neuron | adult stage, with Scer\GAL4^ninaE.PT

Lsd-1^UAS.EGFP

wing, with Scer\GAL4^Bx-MS1096

Lsd-1^GD6641

wing pouch, with Scer\GAL4^Bx-MS1096

Lsd-1^GD6641

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (5)

Hsap\PLIN3

5 of 14

Yes

Hsap\PLIN5

5 of 14

Yes

Hsap\PLIN2

4 of 14

Hsap\PLIN1

3 of 14

Hsap\PLIN4

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (5)

Rnor\Plin2

4 of 14

Yes

3 of 14

3 of 14

2 of 14

1 of 14

Mus musculus (laboratory mouse) (5)

Mmus\Plin5

4 of 14

Yes

3 of 14

3 of 14

3 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (4)

Xtro\plin2

6 of 13

Yes

Xtro\plin1

4 of 13

Yes

Xtro\plin3

4 of 13

Xtro\LOC101734278

1 of 13

Danio rerio (Zebrafish) (5)

Drer\plin2

5 of 14

Yes

3 of 14

2 of 14

2 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (0)

Anopheles gambiae (African malaria mosquito) (2)

Agam\AgaP_AGAP002890

11 of 12

Yes

Agam\AgaP_AGAP000167

2 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Lsd-1. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (1)

Lsd-2

4 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

obesity, susceptibility to (postulated), PLIN-related

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 3 )

Allele

Disease

Evidence

References

Lsd-1¹

model of obesity

CEA

(Beller et al., 2010)

Lsd-1²

model of obesity

CEA with Lsd-1¹

(Beller et al., 2010)

Lsd-1^RNAi.UAS.cBa

model of obesity

CEA

(Beller et al., 2010)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 2 )

Allele

Disease

Interaction

References

Lsd-1¹

model of obesity

is exacerbated by AkhR¹

(Beller et al., 2010)

is exacerbated by bmm¹

(Beller et al., 2010)

is ameliorated by Pka-C1^UAS.cKa

(Beller et al., 2010)

is ameliorated by bmm^UAS.cGa

(Beller et al., 2010)

Lsd-1^UAS.EGFP

exacerbates Parkinson's disease 1

modeled by Hsap\SNCA^UAS.cFa

(Girard et al., 2021)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

5 of 14

5 of 14

4 of 14

3 of 14

LIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 4; FPLD4

familial partial lipodystrophy type 4

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Lsd-1 - Bre1

anti bait coimmunoprecipitation, western blot

(Lin et al., 2024)

Lsd-1 - CG11700

split luciferase complementation, luminiscence technology

(Kolkhof et al., 2017)

Lsd-1 - CG7900

colocalization, fluorescence microscopy, inferred by author

(Girard et al., 2021)

Lsd-1 - CoRest

anti bait coimmunoprecipitation, western blot

(Shao et al., 2022)

Lsd-1 - Jabba

split luciferase complementation, luminiscence technology

(Kolkhof et al., 2017)

Lsd-1 - Rdh1

anti tag coimmunoprecipitation, anti tag western blot

(Zhao et al., 2022)

Lsd-1 - Ubi-p5E

split luciferase complementation, luminiscence technology

(Kolkhof et al., 2017)

Lsd-1 - Ubi-p63E

split luciferase complementation, luminiscence technology

(Kolkhof et al., 2017)

RNA-protein

Physical Interaction

Assay

References

Lsd-1 - Arlr

anti tag coimmunoprecipitation, quantitative reverse transcription pcr, full identification by RNA sequencing

(Sun et al., 2023)

Lsd-1 - hpRNA:LINR-1

anti bait coimmunoprecipitation, full identification by RNA sequencing, pull down, western blot

(Shao et al., 2022)

Lsd-1 - hpRNA:LINR-2

pull down, western blot, anti bait coimmunoprecipitation, full identification by RNA sequencing

(Shao et al., 2022)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Bi et al., 2012)

suppressible

(Men et al., 2016)

enhanceable

(Bi et al., 2012)

suppressible

(Bi et al., 2012)

enhanceable

(Bi et al., 2012)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Sun et al., 2023)

suppressible

(Wang et al., 2021)

suppressible

(Bi et al., 2012)

enhanceable

(Bi et al., 2012)

suppressible

(Yao et al., 2018)

suppressible

(Wang et al., 2021)

Sod2

suppressible

Lsd-1

(Wang et al., 2021)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

67748

DroID - A comprehensive database of gene and protein interactions.

FBgn0039114

MIST (genetic) - An integrated Molecular Interaction Database

42810

MIST (protein-protein) - An integrated Molecular Interaction Database

42810

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

gene_with_edited_transcript

(Graveley et al., 2011)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-80

Cytogenetic map

95B1-95B1

Sequence location

3R:23,763,857..23,766,662 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

95B1-95B1

Limits computationally determined from genome sequence between P{PZ}l(3)04684⁰⁴⁶⁸⁴ and P{PZ}Atg6⁰⁰⁰⁹⁶

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

95B7-95B9

(Miura, 2001.3.7)

Experimentally Determined Recombination Data

Location

3-80

(FlyBase, 2016)

3-81.9

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (7)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

31784

w¹¹¹⁸; P{EP}Lsd-1^G4304

27828

w¹¹¹⁸; Mi{ET1}Lsd-1^MB10034

94601

w^*; TI{TI}Lsd-1^GFP/TM6B, Tb¹

65020

y¹ sc^* v¹ sev²¹; P{TRiP.HMC05894}attP40

97723

y¹ w^*; TI{CRIMIC.TG4.1}Lsd-1^{CR02993-TG4.1}/TM3, Sb¹ Ser¹

VDRC

v106891

P{KK111944}VIE-260B

v30884

w¹¹¹⁸; P{GD6641}v30884

Genomic Clones (18)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (46)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

FI19802

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0039114

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0039114

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Beller et al., 2010, Beller et al., 2010)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Lsd-1 modulates the access of proteins to the lipid droplet surface, shapes lipid droplet structure and has a role in regulation of lipid storage.

(Beller et al., 2010)

The Hrp59 protein binds preferentially to a subset of mRNAs, including Lsd-1 mRNA.

(Kiesler et al., 2005)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (20)

Reported As

Symbol Synonym

CG10374

(Zhao et al., 2022, Aradska et al., 2015, Hosono et al., 2015, Lin et al., 2014, Cammarato et al., 2011, Kühnlein, 2011, Keleman et al., 2009.8.5, Perkins et al., 2009, Beller et al., 2006)

DmPLIN1

(Lee et al., 2013)

LSD-1

(Thanh et al., 2020, Li et al., 2012, Beller et al., 2010, Pospisilik et al., 2010, Miura et al., 2002)

LSD1

(Zhimulev et al., 2024, Richards et al., 2022, Liu et al., 2020, Toprak et al., 2020, Ugrankar et al., 2019, Rennie et al., 2018, Zheng et al., 2016)

LSDP1

(Miura, 2001.3.7)

Lsd1

(Lin et al., 2024, Qian et al., 2023, Song et al., 2022, Zhou et al., 2022, De Groef et al., 2021, Gong et al., 2021, Moraes and Montagne, 2021, Onishi et al., 2021, Vidaurre and Chen, 2021, Cacchione et al., 2020, Zheng et al., 2017, Men et al., 2016, Lin et al., 2014, Arrese et al., 2008, Arrese et al., 2008, Kiesler et al., 2005)

Lsdp1

(Giot et al., 2003)

PLIN1

(Heier et al., 2021, Girard et al., 2020, Toprak et al., 2020, Zheng et al., 2016, Lin et al., 2014, Thiel et al., 2013, Kuhnlein, 2012)

Plin1

(Alassaf et al., 2025, Wang et al., 2023, Zhao et al., 2022, Musselman and Kühnlein, 2018)

dLSD1

(Ullah et al., 2022)

dPlin1

(Girard et al., 2021)

dmPLIN1

(Kolkhof et al., 2017)

lsd-1

(De Groef et al., 2024, Lourido et al., 2021, Harsh et al., 2019)

plin1

(Wang et al., 2021, Kierdorf et al., 2020, Harsh et al., 2019, Yao et al., 2018, Yan et al., 2017, Bi et al., 2012, Wang et al., 2012, Beller et al., 2010, Beller et al., 2010)

Name Synonyms

Lipid storage droplet-1

(Newell et al., 2020, Icreverzi et al., 2015, Cammarato et al., 2011, Kühnlein, 2011, Kühnlein, 2010, Miura et al., 2002)

Lipid storage droplets surface binding protein

lipid storage droplet protein 1

(Lin et al., 2014, Parisi et al., 2010, Arrese et al., 2008)

perilipin

(Lee et al., 2013)

perilipin 1

(Eickelberg et al., 2022)

Secondary FlyBase IDs

Datasets (2)

Study focus (2)

Experimental Role

Project

Project Type

Title

bait_protein

modENCODE_chromatin_proteins_cells

genome binding

Genome-wide localization of chromosomal proteins in cell lines by ChIP-chip and ChIP-Seq.

bait_protein

modENCODE_chromatin_proteins_flies

genome binding

Genome-wide localization of chromosomal proteins in fly tissues by ChIP-chip and ChIP-Seq.

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 49 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

42810

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VCI3

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VCI3

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

A0A0B4KHZ1

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VCI3

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0039114

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42810/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0039114

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0039114

FlyMine - An integrated database for Drosophila genomics

FBgn0039114

InterPro - A database of protein families, domains and functional sites

Perilipin

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG10374

MARRVEL_MODEL - MARRVEL (model organism gene)

42810

Linkouts

BioGRID - A database of protein and genetic interactions.

67748

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0039114

DroID - A comprehensive database of gene and protein interactions.

FBgn0039114

DRSC - Results frm RNAi screens

FBgn0039114

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0039114

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0039114

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG10374

Flygut - An atlas of the Drosophila adult midgut

FBgn0039114

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0039114

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC001324

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (genetic) - An integrated Molecular Interaction Database

42810

MIST (protein-protein) - An integrated Molecular Interaction Database

42810

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (130)

The following external sites may use different assemblies or annotations than FlyBase.

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