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Gene Dmel\CG10214

General Information
Symbol	Dmel\CG10214	Species	D. melanogaster
Name		Annotation symbol	CG10214
Feature type	protein_coding_gene	FlyBase ID	FBgn0039115
Gene Model Status	Current	Stock availability	5 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	95B1-95B1	Sequence location	3R:19,592,241..19,593,210 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG10214 (FBgn0039115). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: oligonucleotidase activity. The biological processes in which it is involved are not known. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Exonuclease; Exonuclease, RNase T/DNA polymerase III; Ribonuclease H-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1628044_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG10214. Gene sequence location is 3R:19592241..19593210.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 95B1-95B1   Limits computationally determined from genome sequence between P{PZ}l(3)0468404684 and P{PZ}Atg600096
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG10214 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG10214-RA FBtr0084463  NM_142927   970   211
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG10214-PA   FBpp0083854   24.3   211   6.93     NP_651184   AAF56185
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Exonuclease (IPR006055) Ribonuclease H-like domain (IPR012337) Exonuclease, RNase T/DNA polymerase III (IPR013520) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME10214
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA539060   AE014297 AAF56185   AW942496   AY061251 AAL28799   BZ665674   CO274297   CO315876   EC089321   EC209446   FF579467
UniProtKB/Swiss-Prot	Q9VCI0
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) visceral muscle primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   crystal cell   (Fisher et al., 2012) dorsal pharyngeal muscle   (Fisher et al., 2012) embryonic/larval muscle system   (Fisher et al., 2012) embryonic/larval somatic muscle   (Fisher et al., 2012) embryonic/larval visceral muscle   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    256.525 Larval Midgut    180.1 Larval Hindgut    163.5 Larval Malpighian Tubules    239.7 Larval Fat Body    165 Larval Salivary Gland    247.5 Larval Trachea    210.1 Larval Carcass    196.55 Adult Head    170.7 Adult Eye    137.875 Adult Brain    189.6 Adult Thoracic-Abdominal Ganglion    185 Adult Crop    163.6 Adult Midgut    216 Adult Hindgut    171.2 Adult Malpighian Tubules    146.7 Adult Fat Body    174.3 Adult Salivary Gland    200.2 Adult Heart    128.55 Adult VirginFemale Spermatheca    138.1 Adult InseminatedFemale Spermatheca    150.2 Adult Ovary    419 Adult Testis    82.1 Adult Male Accessory Gland    325.9 Adult Carcass    181.6 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    256.525 Larval Midgut    180.1 Larval Hindgut    163.5 Larval Malpighian Tubules    239.7 Larval Fat Body    165 Larval Salivary Gland    247.5 Larval Trachea    210.1 Larval Carcass    196.55 Adult Head    170.7 Adult Eye    137.875 Adult Brain    189.6 Adult Thoracic-Abdominal Ganglion    185 Adult Crop    163.6 Adult Midgut    216 Adult Hindgut    171.2 Adult Malpighian Tubules    146.7 Adult Fat Body    174.3 Adult Salivary Gland    200.2 Adult Heart    128.55 Adult VirginFemale Spermatheca    138.1 Adult InseminatedFemale Spermatheca    150.2 Adult Ovary    419 Adult Testis    82.1 Adult Male Accessory Gland    325.9 Adult Carcass    181.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    256.525 Larval Midgut    180.1 Larval Hindgut    163.5 Larval Malpighian Tubules    239.7 Larval Fat Body    165 Larval Salivary Gland    247.5 Larval Trachea    210.1 Larval Carcass    196.55 Adult Head    170.7 Adult Eye    137.875 Adult Brain    189.6 Adult Thoracic-Abdominal Ganglion    185 Adult Crop    163.6 Adult Midgut    216 Adult Hindgut    171.2 Adult Malpighian Tubules    146.7 Adult Fat Body    174.3 Adult Salivary Gland    200.2 Adult Heart    128.55 Adult VirginFemale Spermatheca    138.1 Adult InseminatedFemale Spermatheca    150.2 Adult Ovary    419 Adult Testis    82.1 Adult Male Accessory Gland    325.9 Adult Carcass    181.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    256.525 Larval Midgut    180.1 Larval Hindgut    163.5 Larval Malpighian Tubules    239.7 Larval Fat Body    165 Larval Salivary Gland    247.5 Larval Trachea    210.1 Larval Carcass    196.55 Adult Head    170.7 Adult Eye    137.875 Adult Brain    189.6 Adult Thoracic-Abdominal Ganglion    185 Adult Crop    163.6 Adult Midgut    216 Adult Hindgut    171.2 Adult Malpighian Tubules    146.7 Adult Fat Body    174.3 Adult Salivary Gland    200.2 Adult Heart    128.55 Adult VirginFemale Spermatheca    138.1 Adult InseminatedFemale Spermatheca    150.2 Adult Ovary    419 Adult Testis    82.1 Adult Male Accessory Gland    325.9 Adult Carcass    181.6 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    256.525 Larval Midgut    180.1 Larval Hindgut    163.5 Larval Malpighian Tubules    239.7 Larval Fat Body    165 Larval Salivary Gland    247.5 Larval Trachea    210.1 Larval Carcass    196.55 Adult Head    170.7 Adult Eye    137.875 Adult Brain    189.6 Adult Thoracic-Abdominal Ganglion    185 Adult Crop    163.6 Adult Midgut    216 Adult Hindgut    171.2 Adult Malpighian Tubules    146.7 Adult Fat Body    174.3 Adult Salivary Gland    200.2 Adult Heart    128.55 Adult VirginFemale Spermatheca    138.1 Adult InseminatedFemale Spermatheca    150.2 Adult Ovary    419 Adult Testis    82.1 Adult Male Accessory Gland    325.9 Adult Carcass    181.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    256.525 Larval Midgut    180.1 Larval Hindgut    163.5 Larval Malpighian Tubules    239.7 Larval Fat Body    165 Larval Salivary Gland    247.5 Larval Trachea    210.1 Larval Carcass    196.55 Adult Head    170.7 Adult Eye    137.875 Adult Brain    189.6 Adult Thoracic-Abdominal Ganglion    185 Adult Crop    163.6 Adult Midgut    216 Adult Hindgut    171.2 Adult Malpighian Tubules    146.7 Adult Fat Body    174.3 Adult Salivary Gland    200.2 Adult Heart    128.55 Adult VirginFemale Spermatheca    138.1 Adult InseminatedFemale Spermatheca    150.2 Adult Ovary    419 Adult Testis    82.1 Adult Male Accessory Gland    325.9 Adult Carcass    181.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    256.525 Larval Midgut    180.1 Larval Hindgut    163.5 Larval Malpighian Tubules    239.7 Larval Fat Body    165 Larval Salivary Gland    247.5 Larval Trachea    210.1 Larval Carcass    196.55 Adult Head    170.7 Adult Eye    137.875 Adult Brain    189.6 Adult Thoracic-Abdominal Ganglion    185 Adult Crop    163.6 Adult Midgut    216 Adult Hindgut    171.2 Adult Malpighian Tubules    146.7 Adult Fat Body    174.3 Adult Salivary Gland    200.2 Adult Heart    128.55 Adult VirginFemale Spermatheca    138.1 Adult InseminatedFemale Spermatheca    150.2 Adult Ovary    419 Adult Testis    82.1 Adult Male Accessory Gland    325.9 Adult Carcass    181.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    256.525 Larval Midgut    180.1 Larval Hindgut    163.5 Larval Malpighian Tubules    239.7 Larval Fat Body    165 Larval Salivary Gland    247.5 Larval Trachea    210.1 Larval Carcass    196.55 Adult Head    170.7 Adult Eye    137.875 Adult Brain    189.6 Adult Thoracic-Abdominal Ganglion    185 Adult Crop    163.6 Adult Midgut    216 Adult Hindgut    171.2 Adult Malpighian Tubules    146.7 Adult Fat Body    174.3 Adult Salivary Gland    200.2 Adult Heart    128.55 Adult VirginFemale Spermatheca    138.1 Adult InseminatedFemale Spermatheca    150.2 Adult Ovary    419 Adult Testis    82.1 Adult Male Accessory Gland    325.9 Adult Carcass    181.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    170.7   NA  Eye    137.875   NA  Brain    189.6   256.525  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    185   NA  Crop    163.6   180.1  Midgut    216   163.5  Hindgut    171.2   239.7  Malpighian Tubules    146.7   165  Fat Body    174.3   247.5  Salivary Gland    200.2   NA  Heart    128.55   210.1  Trachea    NA   NA  VirginFemale Spermatheca    138.1   NA  InseminatedFemale Spermatheca    150.2   NA  Ovary    419   NA  Testis    82.1   NA  Male Accessory Gland    325.9   196.55  Carcass    181.6 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    18 central nervous system, larvae L3    15 central nervous system, pupae P8    16 head, virgin 1-day female    10 head, virgin 4-day female    9 head, virgin 20-day female    9 head, mated 1-day female    5 head, mated 4-day female    10 head, mated 20-day female    9 head, mated 1-day male    11 head, mated 4-day male    14 head, mated 20-day male    20 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    10 digestive system, 4-day adult    12 digestive system, 20-day adult    11 fat body, larvae L3 wandering    2 fat body, white prepupae    6 fat body, pupae P8    12 carcass, larvae L3 wandering    11 carcass, 1-day adult    8 carcass, 4-day adult    13 carcass, 20-day adult    11 ovary, virgin 4-day female    61 ovary, mated 4-day female    43 testis, mated 4-day male    12 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    18 central nervous system, larvae L3    15 central nervous system, pupae P8    16 head, virgin 1-day female    10 head, virgin 4-day female    9 head, virgin 20-day female    9 head, mated 1-day female    5 head, mated 4-day female    10 head, mated 20-day female    9 head, mated 1-day male    11 head, mated 4-day male    14 head, mated 20-day male    20 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    10 digestive system, 4-day adult    12 digestive system, 20-day adult    11 fat body, larvae L3 wandering    2 fat body, white prepupae    6 fat body, pupae P8    12 carcass, larvae L3 wandering    11 carcass, 1-day adult    8 carcass, 4-day adult    13 carcass, 20-day adult    11 ovary, virgin 4-day female  (61) ovary, mated 4-day female  (43) testis, mated 4-day male    12 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    18 central nervous system, larvae L3    15 central nervous system, pupae P8    16 head, virgin 1-day female    10 head, virgin 4-day female    9 head, virgin 20-day female    9 head, mated 1-day female    5 head, mated 4-day female    10 head, mated 20-day female    9 head, mated 1-day male    11 head, mated 4-day male    14 head, mated 20-day male    20 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    10 digestive system, 4-day adult    12 digestive system, 20-day adult    11 fat body, larvae L3 wandering    2 fat body, white prepupae    6 fat body, pupae P8    12 carcass, larvae L3 wandering    11 carcass, 1-day adult    8 carcass, 4-day adult    13 carcass, 20-day adult    11 ovary, virgin 4-day female    61 ovary, mated 4-day female    43 testis, mated 4-day male    12 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    18 central nervous system, larvae L3    15 central nervous system, pupae P8    16 head, virgin 1-day female    10 head, virgin 4-day female    9 head, virgin 20-day female    9 head, mated 1-day female    5 head, mated 4-day female    10 head, mated 20-day female    9 head, mated 1-day male    11 head, mated 4-day male    14 head, mated 20-day male    20 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    10 digestive system, 4-day adult    12 digestive system, 20-day adult    11 fat body, larvae L3 wandering    2 fat body, white prepupae    6 fat body, pupae P8    12 carcass, larvae L3 wandering    11 carcass, 1-day adult    8 carcass, 4-day adult    13 carcass, 20-day adult    11 ovary, virgin 4-day female    61 ovary, mated 4-day female    43 testis, mated 4-day male    12 accessory gland, mated 4-day male    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    18 central nervous system, larvae L3    15 central nervous system, pupae P8    16 head, virgin 1-day female    10 head, virgin 4-day female    9 head, virgin 20-day female    9 head, mated 1-day female    5 head, mated 4-day female    10 head, mated 20-day female    9 head, mated 1-day male    11 head, mated 4-day male    14 head, mated 20-day male    20 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    10 digestive system, 4-day adult    12 digestive system, 20-day adult    11 fat body, larvae L3 wandering    2 fat body, white prepupae    6 fat body, pupae P8    12 carcass, larvae L3 wandering    11 carcass, 1-day adult    8 carcass, 4-day adult    13 carcass, 20-day adult    11 ovary, virgin 4-day female    61 ovary, mated 4-day female    43 testis, mated 4-day male    12 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    18 central nervous system, larvae L3    15 central nervous system, pupae P8    16 head, virgin 1-day female    10 head, virgin 4-day female    9 head, virgin 20-day female    9 head, mated 1-day female    5 head, mated 4-day female    10 head, mated 20-day female    9 head, mated 1-day male    11 head, mated 4-day male    14 head, mated 20-day male    20 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    10 digestive system, 4-day adult    12 digestive system, 20-day adult    11 fat body, larvae L3 wandering    2 fat body, white prepupae    6 fat body, pupae P8    12 carcass, larvae L3 wandering    11 carcass, 1-day adult    8 carcass, 4-day adult    13 carcass, 20-day adult    11 ovary, virgin 4-day female  (61) ovary, mated 4-day female  (43) testis, mated 4-day male    12 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    18 central nervous system, larvae L3    15 central nervous system, pupae P8    16 head, virgin 1-day female    10 head, virgin 4-day female    9 head, virgin 20-day female    9 head, mated 1-day female    5 head, mated 4-day female    10 head, mated 20-day female    9 head, mated 1-day male    11 head, mated 4-day male    14 head, mated 20-day male    20 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    10 digestive system, 4-day adult    12 digestive system, 20-day adult    11 fat body, larvae L3 wandering    2 fat body, white prepupae    6 fat body, pupae P8    12 carcass, larvae L3 wandering    11 carcass, 1-day adult    8 carcass, 4-day adult    13 carcass, 20-day adult    11 ovary, virgin 4-day female    61 ovary, mated 4-day female    43 testis, mated 4-day male    12 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    18 central nervous system, larvae L3    15 central nervous system, pupae P8    16 head, virgin 1-day female    10 head, virgin 4-day female    9 head, virgin 20-day female    9 head, mated 1-day female    5 head, mated 4-day female    10 head, mated 20-day female    9 head, mated 1-day male    11 head, mated 4-day male    14 head, mated 20-day male    20 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    10 digestive system, 4-day adult    12 digestive system, 20-day adult    11 fat body, larvae L3 wandering    2 fat body, white prepupae    6 fat body, pupae P8    12 carcass, larvae L3 wandering    11 carcass, 1-day adult    8 carcass, 4-day adult    13 carcass, 20-day adult    11 ovary, virgin 4-day female    61 ovary, mated 4-day female    43 testis, mated 4-day male    12 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    54 embryo 02-04hr    85 embryo 04-06hr    87 embryo 06-08hr    58 embryo 08-10hr    58 embryo 10-12hr    47 embryo 12-14hr    42 embryo 14-16hr    30 embryo 16-18hr    25 embryo 18-20hr    19 embryo 20-22hr    24 embryo 22-24hr    24 larva L1    46 larva L2    36 larva L3 12hr old    21 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    16 white prepupae new    12 white prepupae 12hr    14 white prepupae 24hr    12 pupae 2d postWPP    15 pupae 3d postWPP    14 pupae 4d postWPP    11 adult male 01day    11 adult male 05day    13 adult male 30day    13 adult female 01day    24 adult female 05day    38 adult female 30day    40 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (54) embryo 02-04hr  (85) embryo 04-06hr  (87) embryo 06-08hr  (58) embryo 08-10hr  (58) embryo 10-12hr  (47) embryo 12-14hr  (42) embryo 14-16hr  (30) embryo 16-18hr    25 embryo 18-20hr    19 embryo 20-22hr    24 embryo 22-24hr    24 larva L1  (46) larva L2  (36) larva L3 12hr old    21 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    16 white prepupae new    12 white prepupae 12hr    14 white prepupae 24hr    12 pupae 2d postWPP    15 pupae 3d postWPP    14 pupae 4d postWPP    11 adult male 01day    11 adult male 05day    13 adult male 30day    13 adult female 01day    24 adult female 05day  (38) adult female 30day  (40) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    54 embryo 02-04hr    85 embryo 04-06hr    87 embryo 06-08hr    58 embryo 08-10hr    58 embryo 10-12hr    47 embryo 12-14hr    42 embryo 14-16hr    30 embryo 16-18hr    25 embryo 18-20hr    19 embryo 20-22hr    24 embryo 22-24hr    24 larva L1    46 larva L2    36 larva L3 12hr old    21 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    16 white prepupae new    12 white prepupae 12hr    14 white prepupae 24hr    12 pupae 2d postWPP    15 pupae 3d postWPP    14 pupae 4d postWPP    11 adult male 01day    11 adult male 05day    13 adult male 30day    13 adult female 01day    24 adult female 05day    38 adult female 30day    40 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    54 embryo 02-04hr    85 embryo 04-06hr    87 embryo 06-08hr    58 embryo 08-10hr    58 embryo 10-12hr    47 embryo 12-14hr    42 embryo 14-16hr    30 embryo 16-18hr    25 embryo 18-20hr    19 embryo 20-22hr    24 embryo 22-24hr    24 larva L1    46 larva L2    36 larva L3 12hr old    21 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    16 white prepupae new    12 white prepupae 12hr    14 white prepupae 24hr    12 pupae 2d postWPP    15 pupae 3d postWPP    14 pupae 4d postWPP    11 adult male 01day    11 adult male 05day    13 adult male 30day    13 adult female 01day    24 adult female 05day    38 adult female 30day    40 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    54 embryo 02-04hr    85 embryo 04-06hr    87 embryo 06-08hr    58 embryo 08-10hr    58 embryo 10-12hr    47 embryo 12-14hr    42 embryo 14-16hr    30 embryo 16-18hr    25 embryo 18-20hr    19 embryo 20-22hr    24 embryo 22-24hr    24 larva L1    46 larva L2    36 larva L3 12hr old    21 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    16 white prepupae new    12 white prepupae 12hr    14 white prepupae 24hr    12 pupae 2d postWPP    15 pupae 3d postWPP    14 pupae 4d postWPP    11 adult male 01day    11 adult male 05day    13 adult male 30day    13 adult female 01day    24 adult female 05day    38 adult female 30day    40 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (54) embryo 02-04hr  (85) embryo 04-06hr  (87) embryo 06-08hr  (58) embryo 08-10hr  (58) embryo 10-12hr  (47) embryo 12-14hr  (42) embryo 14-16hr  30 embryo 16-18hr    25 embryo 18-20hr    19 embryo 20-22hr    24 embryo 22-24hr    24 larva L1  (46) larva L2  (36) larva L3 12hr old    21 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    16 white prepupae new    12 white prepupae 12hr    14 white prepupae 24hr    12 pupae 2d postWPP    15 pupae 3d postWPP    14 pupae 4d postWPP    11 adult male 01day    11 adult male 05day    13 adult male 30day    13 adult female 01day    24 adult female 05day  (38) adult female 30day  (40) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    54 embryo 02-04hr    85 embryo 04-06hr    87 embryo 06-08hr    58 embryo 08-10hr    58 embryo 10-12hr    47 embryo 12-14hr    42 embryo 14-16hr    30 embryo 16-18hr    25 embryo 18-20hr    19 embryo 20-22hr    24 embryo 22-24hr    24 larva L1    46 larva L2    36 larva L3 12hr old    21 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    16 white prepupae new    12 white prepupae 12hr    14 white prepupae 24hr    12 pupae 2d postWPP    15 pupae 3d postWPP    14 pupae 4d postWPP    11 adult male 01day    11 adult male 05day    13 adult male 30day    13 adult female 01day    24 adult female 05day    38 adult female 30day    40 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    54 embryo 02-04hr    85 embryo 04-06hr    87 embryo 06-08hr    58 embryo 08-10hr    58 embryo 10-12hr    47 embryo 12-14hr    42 embryo 14-16hr    30 embryo 16-18hr    25 embryo 18-20hr    19 embryo 20-22hr    24 embryo 22-24hr    24 larva L1    46 larva L2    36 larva L3 12hr old    21 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    16 white prepupae new    12 white prepupae 12hr    14 white prepupae 24hr    12 pupae 2d postWPP    15 pupae 3d postWPP    14 pupae 4d postWPP    11 adult male 01day    11 adult male 05day    13 adult male 30day    13 adult female 01day    24 adult female 05day    38 adult female 30day    40 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    40 Schneider line 2 Sg4    24 embryonic 1182-4H    14 embryonic GM2    27 embryonic Kc167    45 embryonic S1    33 embryonic S3    43 leg disc CME L1    32 wing disc CME-W2    38 wing disc ML-DmD8    19 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    26 wing disc ML-DmD21    19 wing disc ML-DmD32    22 haltere disc ML-DmD17-c3    26 eye-antennal disc ML-DmD11    29 antennal disc ML-DmD20-c5    35 mixed discs ML-DmD4-c1    24 CNS ML-DmBG1-c1    42 CNS ML-DmBG2-c2    24 tumorous blood cells mbn2    37 ovary fGS/OSS    21 ovary OSC    23 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (40) Schneider line 2 Sg4    24 embryonic 1182-4H    14 embryonic GM2  (27) embryonic Kc167  (45) embryonic S1  (33) embryonic S3  (43) leg disc CME L1  (32) wing disc CME-W2  (38) wing disc ML-DmD8    19 wing disc ML-DmD9    20 wing disc ML-DmD16-c3  26 wing disc ML-DmD21    19 wing disc ML-DmD32    22 haltere disc ML-DmD17-c3  26 eye-antennal disc ML-DmD11  (29) antennal disc ML-DmD20-c5  (35) mixed discs ML-DmD4-c1    24 CNS ML-DmBG1-c1  (42) CNS ML-DmBG2-c2    24 tumorous blood cells mbn2  (37) ovary fGS/OSS    21 ovary OSC    23 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    40 Schneider line 2 Sg4    24 embryonic 1182-4H    14 embryonic GM2    27 embryonic Kc167    45 embryonic S1    33 embryonic S3    43 leg disc CME L1    32 wing disc CME-W2    38 wing disc ML-DmD8    19 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    26 wing disc ML-DmD21    19 wing disc ML-DmD32    22 haltere disc ML-DmD17-c3    26 eye-antennal disc ML-DmD11    29 antennal disc ML-DmD20-c5    35 mixed discs ML-DmD4-c1    24 CNS ML-DmBG1-c1    42 CNS ML-DmBG2-c2    24 tumorous blood cells mbn2    37 ovary fGS/OSS    21 ovary OSC    23 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    40 Schneider line 2 Sg4    24 embryonic 1182-4H    14 embryonic GM2    27 embryonic Kc167    45 embryonic S1    33 embryonic S3    43 leg disc CME L1    32 wing disc CME-W2    38 wing disc ML-DmD8    19 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    26 wing disc ML-DmD21    19 wing disc ML-DmD32    22 haltere disc ML-DmD17-c3    26 eye-antennal disc ML-DmD11    29 antennal disc ML-DmD20-c5    35 mixed discs ML-DmD4-c1    24 CNS ML-DmBG1-c1    42 CNS ML-DmBG2-c2    24 tumorous blood cells mbn2    37 ovary fGS/OSS    21 ovary OSC    23 ovary OSS    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    40 Schneider line 2 Sg4    24 embryonic 1182-4H    14 embryonic GM2    27 embryonic Kc167    45 embryonic S1    33 embryonic S3    43 leg disc CME L1    32 wing disc CME-W2    38 wing disc ML-DmD8    19 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    26 wing disc ML-DmD21    19 wing disc ML-DmD32    22 haltere disc ML-DmD17-c3    26 eye-antennal disc ML-DmD11    29 antennal disc ML-DmD20-c5    35 mixed discs ML-DmD4-c1    24 CNS ML-DmBG1-c1    42 CNS ML-DmBG2-c2    24 tumorous blood cells mbn2    37 ovary fGS/OSS    21 ovary OSC    23 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (40) Schneider line 2 Sg4    24 embryonic 1182-4H    14 embryonic GM2  27 embryonic Kc167  (45) embryonic S1  (33) embryonic S3  (43) leg disc CME L1  32 wing disc CME-W2  (38) wing disc ML-DmD8    19 wing disc ML-DmD9    20 wing disc ML-DmD16-c3  26 wing disc ML-DmD21    19 wing disc ML-DmD32    22 haltere disc ML-DmD17-c3  26 eye-antennal disc ML-DmD11  29 antennal disc ML-DmD20-c5  (35) mixed discs ML-DmD4-c1    24 CNS ML-DmBG1-c1  (42) CNS ML-DmBG2-c2    24 tumorous blood cells mbn2  (37) ovary fGS/OSS    21 ovary OSC    23 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    40 Schneider line 2 Sg4    24 embryonic 1182-4H    14 embryonic GM2    27 embryonic Kc167    45 embryonic S1    33 embryonic S3    43 leg disc CME L1    32 wing disc CME-W2    38 wing disc ML-DmD8    19 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    26 wing disc ML-DmD21    19 wing disc ML-DmD32    22 haltere disc ML-DmD17-c3    26 eye-antennal disc ML-DmD11    29 antennal disc ML-DmD20-c5    35 mixed discs ML-DmD4-c1    24 CNS ML-DmBG1-c1    42 CNS ML-DmBG2-c2    24 tumorous blood cells mbn2    37 ovary fGS/OSS    21 ovary OSC    23 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    40 Schneider line 2 Sg4    24 embryonic 1182-4H    14 embryonic GM2    27 embryonic Kc167    45 embryonic S1    33 embryonic S3    43 leg disc CME L1    32 wing disc CME-W2    38 wing disc ML-DmD8    19 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    26 wing disc ML-DmD21    19 wing disc ML-DmD32    22 haltere disc ML-DmD17-c3    26 eye-antennal disc ML-DmD11    29 antennal disc ML-DmD20-c5    35 mixed discs ML-DmD4-c1    24 CNS ML-DmBG1-c1    42 CNS ML-DmBG2-c2    24 tumorous blood cells mbn2    37 ovary fGS/OSS    21 ovary OSC    23 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    3 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    30 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    36 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    26 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    20 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    3 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult  (30) Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3  (28) Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (36) Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult  26 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    20 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    3 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    30 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    36 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    26 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    20 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    3 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    30 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    36 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    26 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    20 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    3 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    30 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    36 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    26 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    20 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    3 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult  30 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3  28 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (36) Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult  26 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    20 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    3 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    30 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    36 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    26 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    20 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    3 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    30 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    36 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    26 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    20 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_08 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • LD18757 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039115 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10214-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG10214GD6903 Phenotype manifest in Allele
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of CG10214 Class Mutagen Stocks Known lesion CG102145-HA-5044 1 -- CG10214KG09291 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG10214 Class Mutagen Stocks Known lesion CG10214GD6903 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG10214KK109035 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG10214NIG.10214R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel9013 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD6903} NA P{KK109035} NA P{NIG.10214R} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{RS5}CG102145-HA-5044 NA P{SUPor-P}CG10214KG09291 NA
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
3'-5'-exoribonuclease activity non-traceable author statement (Swiss-Prot Project Members, 2000.10.1) exonuclease activity inferred from electronic annotation with InterPro:IPR006055 (FlyBase Curators et al., 2004-) nucleic acid binding inferred from electronic annotation with InterPro:IPR012337 (FlyBase Curators et al., 2004-) oligonucleotidase activity inferred from sequence or structural similarity with UniProtKB:Q9Y3B8 (Sardiello et al., 2003.6.11)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
mitochondrion inferred from sequence or structural similarity with UniProtKB:Q9Y3B8 (Sardiello et al., 2003.6.11) nucleus inferred from sequence or structural similarity with UniProtKB:Q9Y3B8 (Sardiello et al., 2003.6.11)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
CG10214 - Df31 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) CG10214 - Hsp60 experimental knowledge based (Guruharsha et al., 2011) CG10214 - Ote anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) CG10214 - Sod experimental knowledge based (Guruharsha et al., 2011) CG10214 - baf experimental knowledge based (Guruharsha et al., 2011) CG10214 - mtSSB experimental knowledge based (Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG10214 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67749 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0039115 DroID - A comprehensive database of gene and protein interactions. • FBgn0039115 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42811
Orthologs
OrthoDB Orthologs (47) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG60S124 Dipteran inclusive ortholog search EOG6Z0BFW Insect inclusive ortholog search EOG6NCK97 Arthropod inclusive ortholog search EOG6Q2BZ1 Metazoa inclusive ortholog search EOG6C5RD9
Orthologs in Drosophila Species (EOG60S124)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG10214     Drosophila simulans   Dsim\GD18354 Y   Drosophila sechellia   Dsec\GM23540 Y   Drosophila erecta   Dere\GG12405 Y   Drosophila yakuba   Dyak\GE23924 Y   Drosophila ananassae   Dana\GF18739 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA10162 Y   Drosophila persimilis   Dper\GL24271 Y   Drosophila willistoni   Dwil\GK22765 Y   Drosophila virilis   Dvir\GJ24646 Y   Drosophila mojavensis   Dmoj\GI22396 Y   Drosophila grimshawi   Dgri\GH11306 Y
Orthologs in non-Drosophila Dipterans (EOG6Z0BFW)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL008865   Anopheles gambiae Malaria mosquito  Agam\AGAP004759   Anopheles gambiae Malaria mosquito  Agam\AGAP012804   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ011181
Orthologs in non-Dipteran Insects (EOG6NCK97)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB54960   Apis mellifera Western honey bee  Amel\GB47487   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG011278   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG011228   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG006409   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH18681   Atta cephalotes Leafcutter ant  Acep\ACEP14741   Atta cephalotes Leafcutter ant  Acep\orn   Camponotus floridanus Florida carpenter ant  Cflo\CFLO15317   Camponotus floridanus Florida carpenter ant  Cflo\CFLO12595   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL14167   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL21487   Linepithema humile Argentine ant  Lhum\LH11333   Pogonomyrmex barbatus Red harvester ant  Pbar\PB21859   Pogonomyrmex barbatus Red harvester ant  Pbar\PB20465   Solenopsis invicta Red fire ant  Sinv\SINV25464   Solenopsis invicta Red fire ant  Sinv\SINV24456   Acyrthosiphon pisum Pea aphid  Apim\ACYPI004795   Bombyx mori Silkmoth  Bmor\BGIBMGA011592   Pediculus humanus Human body louse  Phum\PHUM357250   Tribolium castaneum Red flour beetle  Tcas\TC008587
Orthologs in non-Insect Arthropods (EOG6Q2BZ1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\MOB1B   Ixodes scapularis Deer tick  Isca\ISCW008878
Orthologs in non-Arthropod Metazoa (EOG6C5RD9)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\C08B6.8   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_019393gn   Danio rerio Zebrafish  Drer\smfn   Xenopus tropicalis Western clawed frog  Xtro\rexo2   Gallus gallus Domestic chicken  Ggal\REXO2   Mus musculus House mouse  Mmus\Rexo2   Rattus norvegicus Norway rat  Rnor\Rexo2   Homo sapiens Human  Hsap\REXO2
Human Orthologs (1)
Gene OMIM HGNC Hsap\REXO2
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD18354 Drosophila sechellia Dsec\GM23540 Drosophila erecta Dere\GG12405 Drosophila yakuba Dyak\GE23924 Drosophila ananassae Dana\GF18739 Drosophila pseudoobscura pseudoobscura Dpse\GA10162 Drosophila persimilis Dper\GL24271 Drosophila willistoni Dwil\GK22765 Drosophila virilis Dvir\GJ24646 Drosophila mojavensis Dmoj\GI22396 Drosophila grimshawi Dgri\GH11306
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	15177 y1; ry506 P{SUPor-P}CG10214KG09291/TM3, Sb1 Ser1
Kyoto	125806 w1118; P{RS5}CG102145-HA-5044
VDRC	v101393 P{KK109035}VIE-260B v18035 w1118; P{GD6903}v18035 v18033 w1118; P{GD6903}v18033/CyO
Genomic Clones ( 2 )
	BACR11E07 BACR16I18 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 7 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD18757
Other clones	DPiM_LD18757
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	12623 160039 EK113735 EK262914 Fernando_27_A11
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0039115 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42811
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_142927 RefSeq (Proteins) • NP_651184 DDBJ / EMBL / GenBank • AA539060 AAF56185 AAL28799 AW942496 AY061251 BZ665674 Entrez Gene - A searchable database of RefSeq genes. • 42811 UniProtKB/Swiss-Prot • Q9VCI0
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Exonuclease (IPR006055) Ribonuclease H-like domain (IPR012337) Exonuclease, RNase T/DNA polymerase III (IPR013520) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME10214 BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD18757
Linkouts
	BioGRID - A database of protein and genetic interactions • 67749 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0039115 DroID - A comprehensive database of gene and protein interactions. • FBgn0039115 DRSC - Results from RNAi screens. • FBgn0039115 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039115 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10214-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0039115 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42811 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42811 modMine - Data generated by the modENCODE project. • FBgn0039115
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG10214 (Liu et al., 2011, Han et al., 2011, Keleman et al., 2009.8.5, Beller et al., 2010, Japanese National Institute of Genetics, 2012.5.21)
Name Synonym
Secondary FlyBase IDs
References ( 23 )
Generate a list of	All references relating to this gene ( 23 )
List References by type	Research paper  ( 5 ) Supplementary material  ( 5 ) Personal communication to FlyBase  ( 8 ) FlyBase analysis  ( 1 ) Stock list  ( 1 ) Protein sequence record  ( 1 ) Website  ( 1 )
Recent research papers ( 2 )
	Han et al., 2011, Curr. Biol. 21(22): 1878--1887 The 3'-to-5' Exoribonuclease Nibbler Shapes the 3' Ends of MicroRNAs Bound to Drosophila Argonaute1. [FBrf0216729] Liu et al., 2011, Curr. Biol. 21(22): 1888--1893 The Exoribonuclease Nibbler Controls 3' End Processing of MicroRNAs in Drosophila. [FBrf0216782] Show all research papers ...