A Database of Drosophila Genes & Genomes

FB2012_01, released January 20th, 2012
 

Gene Dmel\Nup98-96

General Information
SymbolDmel\Nup98-96SpeciesD. melanogaster
NameNucleoporin 98-96Annotation symbolCG10198
Feature typeprotein_coding_geneFlyBase IDFBgn0039120
Gene Model StatusCurrent Stock availability 5 publicly available
Also Known AsNup98, Nup96, l(3)95BCd
Genomic Location
Chromosome (arm)3RRecombination map
Cytogenetic map95B1-95B5Sequence location3R:19,599,947..19,607,366 [-]

Genomic Maps

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modENCODE GBrowse
detailed view
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Automatically generated summary

See sections below for more information
The gene Nucleoporin 98-96 is referred to in FlyBase by the symbol Dmel\Nup98-96 (CG10198, FBgn0039120). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: germ-line stem cell maintenance; SMAD protein import into nucleus; phagocytosis, engulfment. 14 alleles are reported. The phenotypes of these alleles are annotated with: female fusome; nurse cell spectrosome; male germline cell. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Nuclear protein 96; Peptidase S59, nucleoporin. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval salivary gland, larval trachea, adult ovary, adult testis, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1632194_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Nup98. Gene sequence location is 3R:19599947..19607366.

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Description
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This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).
What does this section not display?
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FB2011_10
References
FB2012_01
Transgenic Constructs
Controlled Vocabulary Terms
Insertions
Alleles
Sequence features
All updates Click here to see a list of all updates to this record from FB2010_08 and on.
hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
95B1-95B5  
Limits computationally determined from genome sequence between P{PZ}l(3)0468404684 and P{PZ}Atg600096  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
hide Gene Model & Products
Please see the GBrowse view of Dmel\Nup98-96 for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
detailed view FBtr0084462 FBtr0084461 FBtr0304567 FBtr0084460 FBtr0304729 FBtr0084459 FBpp0083853 FBpp0083852 FBpp0293109 FBpp0083851 FBpp0293271 FBpp0083850 FBti0042639 FBti0053432 FBti0106530 FBti0029607 FBti0039164 FBti0124341 FBti0112054 FBti0036256 FBti0075881 FBti0072089 FBti0107176 FBti0055962 FBti0025198 FBti0036651 FBti0107088 FBti0143988 FBti0105642 FBti0100179 FBti0106161 FBti0011333 FBti0103920 FBti0103919 FBti0028137
Comments on Gene Model
The larger Nup98-RA transcript encodes a single, large precursor polyprotein that, in other eukaryotes, and thus presumably in flies, autoproteolytically cleaves itself between residues Phe1028 and Ser1029, yielding separate Nup98 and Nup96 proteins (FBrf0159638).
Gene model reviewed during 5.41
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
FBtr0084460
  6647
  1960
FBtr0304567
 
  3987
  1179
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
FBpp0083851  
210.1  
1960  
6.50  
FBpp0293109  
121.6  
1179  
6.47  
 
 
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
hide Mapped Features
Mapped Features have been reorganized, please see this article for details.
Additional mapped features and mutations can be found on GBrowse or related reports.
Type
Symbol & Location
Additional Notes
References
hide External Data
Linkouts
Crossreferences
hide Expression Data
hideTranscript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
hidePolypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
hide High-Throughput Expression Data
or
Untitled Document detailed view CG10208-RA Nup98-96-RC Nup98-96-RA mbc-RB mbc-RA
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

modENCODE Temporal Expression Data for FBgn0039120


   Styles
Linear
Logarithmic
Heatmap
   Scales
max expr for FBgn0039120
Very low expression bin max
Moderate expression bin max
High expression bin max
Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages.
[download data (TSV)]

Guide to modENCODE expression level colors
 
No expression (0 - 0)
 
Extremely low expression (1 - 10)
 
Very low expression (11 - 100)
 
Low expression (101 - 400)
 
Moderate expression (401 - 1400)
 
Moderately high expression (1401 - 4000)
 
High expression (4001 - 10000)
 
Very high expression (10001 - 100000)
 
Extremely high expression (100001 - 2000000)

Linear, scaled to maximum FBgn0039120 expression level
Developmental Stage   Expression Level
embryo 00-02hr
 
 5145
embryo 02-04hr
 
 3831
embryo 04-06hr
 
 4946
embryo 06-08hr
 
 3703
embryo 08-10hr
 
 2944
embryo 10-12hr
 
 1618
embryo 12-14hr
 
 1596
embryo 14-16hr
 
 1285
embryo 16-18hr
 
 1007
embryo 18-20hr
 
 647
embryo 20-22hr
 
 798
embryo 22-24hr
 
 822
larva L1
 
 1229
larva L2
 
 1130
larva L3 12hr old
 
 921
larva L3 puffstage 1-2
 
 760
larva L3 puffstage 3-6
 
 1193
larva L3 puffstage 7-9
 
 1290
white prepupae new
 
 1259
white prepupae 12hr
 
 1407
white prepupae 24hr
 
 1657
pupae 2d postWPP
 
 1093
pupae 3d postWPP
 
 675
pupae 4d postWPP
 
 678
adult male 01day
 
 840
adult male 05day
 
 1208
adult male 30day
 
 1074
adult female 01day
 
 1710
adult female 05day
 
 3412
adult female 30day
 
 3380
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
Linear, scaled to Very low expression
Developmental Stage   Expression Level
embryo 00-02hr
 (5145)
embryo 02-04hr
 (3831)
embryo 04-06hr
 (4946)
embryo 06-08hr
 (3703)
embryo 08-10hr
 (2944)
embryo 10-12hr
 (1618)
embryo 12-14hr
 (1596)
embryo 14-16hr
 (1285)
embryo 16-18hr
 (1007)
embryo 18-20hr
 (647)
embryo 20-22hr
 (798)
embryo 22-24hr
 (822)
larva L1
 (1229)
larva L2
 (1130)
larva L3 12hr old
 (921)
larva L3 puffstage 1-2
 (760)
larva L3 puffstage 3-6
 (1193)
larva L3 puffstage 7-9
 (1290)
white prepupae new
 (1259)
white prepupae 12hr
 (1407)
white prepupae 24hr
 (1657)
pupae 2d postWPP
 (1093)
pupae 3d postWPP
 (675)
pupae 4d postWPP
 (678)
adult male 01day
 (840)
adult male 05day
 (1208)
adult male 30day
 (1074)
adult female 01day
 (1710)
adult female 05day
 (3412)
adult female 30day
 (3380)
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
Linear, scaled to Moderate expression
Developmental Stage   Expression Level
embryo 00-02hr
 (5145)
embryo 02-04hr
 (3831)
embryo 04-06hr
 (4946)
embryo 06-08hr
 (3703)
embryo 08-10hr
 (2944)
embryo 10-12hr
 (1618)
embryo 12-14hr
 (1596)
embryo 14-16hr
 
 1285
embryo 16-18hr
 
 1007
embryo 18-20hr
 
 647
embryo 20-22hr
 
 798
embryo 22-24hr
 
 822
larva L1
 
 1229
larva L2
 
 1130
larva L3 12hr old
 
 921
larva L3 puffstage 1-2
 
 760
larva L3 puffstage 3-6
 
 1193
larva L3 puffstage 7-9
 
 1290
white prepupae new
 
 1259
white prepupae 12hr
 1407
white prepupae 24hr
 (1657)
pupae 2d postWPP
 
 1093
pupae 3d postWPP
 
 675
pupae 4d postWPP
 
 678
adult male 01day
 
 840
adult male 05day
 
 1208
adult male 30day
 
 1074
adult female 01day
 (1710)
adult female 05day
 (3412)
adult female 30day
 (3380)
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
Linear, scaled to High expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 5145
embryo 02-04hr
 
 3831
embryo 04-06hr
 
 4946
embryo 06-08hr
 
 3703
embryo 08-10hr
 
 2944
embryo 10-12hr
 
 1618
embryo 12-14hr
 
 1596
embryo 14-16hr
 
 1285
embryo 16-18hr
 
 1007
embryo 18-20hr
 
 647
embryo 20-22hr
 
 798
embryo 22-24hr
 
 822
larva L1
 
 1229
larva L2
 
 1130
larva L3 12hr old
 
 921
larva L3 puffstage 1-2
 
 760
larva L3 puffstage 3-6
 
 1193
larva L3 puffstage 7-9
 
 1290
white prepupae new
 
 1259
white prepupae 12hr
 
 1407
white prepupae 24hr
 
 1657
pupae 2d postWPP
 
 1093
pupae 3d postWPP
 
 675
pupae 4d postWPP
 
 678
adult male 01day
 
 840
adult male 05day
 
 1208
adult male 30day
 
 1074
adult female 01day
 
 1710
adult female 05day
 
 3412
adult female 30day
 
 3380
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Extremely high expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 5145
embryo 02-04hr
 
 3831
embryo 04-06hr
 
 4946
embryo 06-08hr
 
 3703
embryo 08-10hr
 
 2944
embryo 10-12hr
 
 1618
embryo 12-14hr
 
 1596
embryo 14-16hr
 
 1285
embryo 16-18hr
 
 1007
embryo 18-20hr
 
 647
embryo 20-22hr
 
 798
embryo 22-24hr
 
 822
larva L1
 
 1229
larva L2
 
 1130
larva L3 12hr old
 
 921
larva L3 puffstage 1-2
 
 760
larva L3 puffstage 3-6
 
 1193
larva L3 puffstage 7-9
 
 1290
white prepupae new
 
 1259
white prepupae 12hr
 
 1407
white prepupae 24hr
 
 1657
pupae 2d postWPP
 
 1093
pupae 3d postWPP
 
 675
pupae 4d postWPP
 
 678
adult male 01day
 
 840
adult male 05day
 
 1208
adult male 30day
 
 1074
adult female 01day
 
 1710
adult female 05day
 
 3412
adult female 30day
 
 3380
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
log, scaled to maximum FBgn0039120 expression level
Developmental Stage   Expression Level
embryo 00-02hr
 
 5145
embryo 02-04hr
 
 3831
embryo 04-06hr
 
 4946
embryo 06-08hr
 
 3703
embryo 08-10hr
 
 2944
embryo 10-12hr
 
 1618
embryo 12-14hr
 
 1596
embryo 14-16hr
 
 1285
embryo 16-18hr
 
 1007
embryo 18-20hr
 
 647
embryo 20-22hr
 
 798
embryo 22-24hr
 
 822
larva L1
 
 1229
larva L2
 
 1130
larva L3 12hr old
 
 921
larva L3 puffstage 1-2
 
 760
larva L3 puffstage 3-6
 
 1193
larva L3 puffstage 7-9
 
 1290
white prepupae new
 
 1259
white prepupae 12hr
 
 1407
white prepupae 24hr
 
 1657
pupae 2d postWPP
 
 1093
pupae 3d postWPP
 
 675
pupae 4d postWPP
 
 678
adult male 01day
 
 840
adult male 05day
 
 1208
adult male 30day
 
 1074
adult female 01day
 
 1710
adult female 05day
 
 3412
adult female 30day
 
 3380
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Very low expression
Developmental Stage   Expression Level
embryo 00-02hr
 (5145)
embryo 02-04hr
 (3831)
embryo 04-06hr
 (4946)
embryo 06-08hr
 (3703)
embryo 08-10hr
 (2944)
embryo 10-12hr
 (1618)
embryo 12-14hr
 (1596)
embryo 14-16hr
 (1285)
embryo 16-18hr
 (1007)
embryo 18-20hr
 (647)
embryo 20-22hr
 (798)
embryo 22-24hr
 (822)
larva L1
 (1229)
larva L2
 (1130)
larva L3 12hr old
 (921)
larva L3 puffstage 1-2
 (760)
larva L3 puffstage 3-6
 (1193)
larva L3 puffstage 7-9
 (1290)
white prepupae new
 (1259)
white prepupae 12hr
 (1407)
white prepupae 24hr
 (1657)
pupae 2d postWPP
 (1093)
pupae 3d postWPP
 (675)
pupae 4d postWPP
 (678)
adult male 01day
 (840)
adult male 05day
 (1208)
adult male 30day
 (1074)
adult female 01day
 (1710)
adult female 05day
 (3412)
adult female 30day
 (3380)
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
log, scaled to Moderate expression
Developmental Stage   Expression Level
embryo 00-02hr
 (5145)
embryo 02-04hr
 (3831)
embryo 04-06hr
 (4946)
embryo 06-08hr
 (3703)
embryo 08-10hr
 (2944)
embryo 10-12hr
 1618
embryo 12-14hr
 1596
embryo 14-16hr
 
 1285
embryo 16-18hr
 
 1007
embryo 18-20hr
 
 647
embryo 20-22hr
 
 798
embryo 22-24hr
 
 822
larva L1
 
 1229
larva L2
 
 1130
larva L3 12hr old
 
 921
larva L3 puffstage 1-2
 
 760
larva L3 puffstage 3-6
 
 1193
larva L3 puffstage 7-9
 
 1290
white prepupae new
 
 1259
white prepupae 12hr
 1407
white prepupae 24hr
 1657
pupae 2d postWPP
 
 1093
pupae 3d postWPP
 
 675
pupae 4d postWPP
 
 678
adult male 01day
 
 840
adult male 05day
 
 1208
adult male 30day
 
 1074
adult female 01day
 1710
adult female 05day
 (3412)
adult female 30day
 (3380)
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
log, scaled to High expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 5145
embryo 02-04hr
 
 3831
embryo 04-06hr
 
 4946
embryo 06-08hr
 
 3703
embryo 08-10hr
 
 2944
embryo 10-12hr
 
 1618
embryo 12-14hr
 
 1596
embryo 14-16hr
 
 1285
embryo 16-18hr
 
 1007
embryo 18-20hr
 
 647
embryo 20-22hr
 
 798
embryo 22-24hr
 
 822
larva L1
 
 1229
larva L2
 
 1130
larva L3 12hr old
 
 921
larva L3 puffstage 1-2
 
 760
larva L3 puffstage 3-6
 
 1193
larva L3 puffstage 7-9
 
 1290
white prepupae new
 
 1259
white prepupae 12hr
 
 1407
white prepupae 24hr
 
 1657
pupae 2d postWPP
 
 1093
pupae 3d postWPP
 
 675
pupae 4d postWPP
 
 678
adult male 01day
 
 840
adult male 05day
 
 1208
adult male 30day
 
 1074
adult female 01day
 
 1710
adult female 05day
 
 3412
adult female 30day
 
 3380
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Extremely high expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 5145
embryo 02-04hr
 
 3831
embryo 04-06hr
 
 4946
embryo 06-08hr
 
 3703
embryo 08-10hr
 
 2944
embryo 10-12hr
 
 1618
embryo 12-14hr
 
 1596
embryo 14-16hr
 
 1285
embryo 16-18hr
 
 1007
embryo 18-20hr
 
 647
embryo 20-22hr
 
 798
embryo 22-24hr
 
 822
larva L1
 
 1229
larva L2
 
 1130
larva L3 12hr old
 
 921
larva L3 puffstage 1-2
 
 760
larva L3 puffstage 3-6
 
 1193
larva L3 puffstage 7-9
 
 1290
white prepupae new
 
 1259
white prepupae 12hr
 
 1407
white prepupae 24hr
 
 1657
pupae 2d postWPP
 
 1093
pupae 3d postWPP
 
 675
pupae 4d postWPP
 
 678
adult male 01day
 
 840
adult male 05day
 
 1208
adult male 30day
 
 1074
adult female 01day
 
 1710
adult female 05day
 
 3412
adult female 30day
 
 3380
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
Heatmap
Developmental Stage   Expression Level
embryo 00-02hr
 
 
embryo 02-04hr
 
 
embryo 04-06hr
 
 
embryo 06-08hr
 
 
embryo 08-10hr
 
 
embryo 10-12hr
 
 
embryo 12-14hr
 
 
embryo 14-16hr
 
 
embryo 16-18hr
 
 
embryo 18-20hr
 
 
embryo 20-22hr
 
 
embryo 22-24hr
 
 
larva L1
 
 
larva L2
 
 
larva L3 12hr old
 
 
larva L3 puffstage 1-2
 
 
larva L3 puffstage 3-6
 
 
larva L3 puffstage 7-9
 
 
white prepupae new
 
 
white prepupae 12hr
 
 
white prepupae 24hr
 
 
pupae 2d postWPP
 
 
pupae 3d postWPP
 
 
pupae 4d postWPP
 
 
adult male 01day
 
 
adult male 05day
 
 
adult male 30day
 
 
adult female 01day
 
 
adult female 05day
 
 
adult female 30day
 
 

FlyAtlas Anatomical Expression Data for FBgn0039120


   Styles
Linear
Logarithmic
Heatmap
Back-to-back
   Scales
max expr for FBgn0039120
Moderate expression bin max
High level expression bin max
Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval salivary gland, larval trachea, adult ovary, adult testis, larval carcass.
[download data (TSV)]

Guide to FlyAtlas expression level colors
 
No expression (0 - 9.999)
 
Low expression (10 - 99.999)
 
Moderate expression (100 - 499.999)
 
High level expression (500 - 999.999)
 
Very high expression (1000 - 25000)

Linear, scaled to maximum FBgn0039120 expression level
Tissue   Expression Level
Larval Central Nervous System
 
 218.075
Larval Midgut no informative data
Larval Hindgut
 
 89.2
Larval Malpighian Tubules
 
 57.3
Larval Fat Body
 
 67.2
Larval Salivary Gland
 
 113.8
Larval Trachea
 
 147.85
Larval Carcass
 
 105.3
Adult Head
 
 41.9
Adult Eye
 
 31.525
Adult Brain
 
 64.6
Adult Thoracic-Abdominal Ganglion
 
 57.2
Adult Crop
 
 44.6
Adult Midgut no informative data
Adult Hindgut
 
 50.9
Adult Malpighian Tubules no informative data
Adult Fat Body no informative data
Adult Salivary Gland no informative data
Adult Heart
 
 32.875
Adult VirginFemale Spermatheca
 
 34.5
Adult InseminatedFemale Spermatheca
 
 43.1
Adult Ovary
 
 277.2
Adult Testis
 
 120.5
Adult Male Accessory Gland
 
 67.6
Adult Carcass no informative data
Expression Level Scale
 None 
 Low 
 Moderate 
Linear, scaled to Moderate expression
Tissue   Expression Level
Larval Central Nervous System
 
 218.075
Larval Midgut no informative data
Larval Hindgut
 
 89.2
Larval Malpighian Tubules
 
 57.3
Larval Fat Body
 
 67.2
Larval Salivary Gland
 
 113.8
Larval Trachea
 
 147.85
Larval Carcass
 
 105.3
Adult Head
 
 41.9
Adult Eye
 
 31.525
Adult Brain
 
 64.6
Adult Thoracic-Abdominal Ganglion
 
 57.2
Adult Crop
 
 44.6
Adult Midgut no informative data
Adult Hindgut
 
 50.9
Adult Malpighian Tubules no informative data
Adult Fat Body no informative data
Adult Salivary Gland no informative data
Adult Heart
 
 32.875
Adult VirginFemale Spermatheca
 
 34.5
Adult InseminatedFemale Spermatheca
 
 43.1
Adult Ovary
 
 277.2
Adult Testis
 
 120.5
Adult Male Accessory Gland
 
 67.6
Adult Carcass no informative data
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
Linear, scaled to High level expression
Tissue   Expression Level
Larval Central Nervous System
 
 218.075
Larval Midgut no informative data
Larval Hindgut
 
 89.2
Larval Malpighian Tubules
 
 57.3
Larval Fat Body
 
 67.2
Larval Salivary Gland
 
 113.8
Larval Trachea
 
 147.85
Larval Carcass
 
 105.3
Adult Head
 
 41.9
Adult Eye
 
 31.525
Adult Brain
 
 64.6
Adult Thoracic-Abdominal Ganglion
 
 57.2
Adult Crop
 
 44.6
Adult Midgut no informative data
Adult Hindgut
 
 50.9
Adult Malpighian Tubules no informative data
Adult Fat Body no informative data
Adult Salivary Gland no informative data
Adult Heart
 
 32.875
Adult VirginFemale Spermatheca
 
 34.5
Adult InseminatedFemale Spermatheca
 
 43.1
Adult Ovary
 
 277.2
Adult Testis
 
 120.5
Adult Male Accessory Gland
 
 67.6
Adult Carcass no informative data
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
Linear, scaled to Very high expression
Tissue   Expression Level
Larval Central Nervous System
 
 218.075
Larval Midgut no informative data
Larval Hindgut
 
 89.2
Larval Malpighian Tubules
 
 57.3
Larval Fat Body
 
 67.2
Larval Salivary Gland
 
 113.8
Larval Trachea
 
 147.85
Larval Carcass
 
 105.3
Adult Head
 
 41.9
Adult Eye
 
 31.525
Adult Brain
 
 64.6
Adult Thoracic-Abdominal Ganglion
 
 57.2
Adult Crop
 
 44.6
Adult Midgut no informative data
Adult Hindgut
 
 50.9
Adult Malpighian Tubules no informative data
Adult Fat Body no informative data
Adult Salivary Gland no informative data
Adult Heart
 
 32.875
Adult VirginFemale Spermatheca
 
 34.5
Adult InseminatedFemale Spermatheca
 
 43.1
Adult Ovary
 
 277.2
Adult Testis
 
 120.5
Adult Male Accessory Gland
 
 67.6
Adult Carcass no informative data
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
log, scaled to maximum FBgn0039120 expression level
Tissue   Expression Level
Larval Central Nervous System
 
 218.075
Larval Midgut no informative data
Larval Hindgut
 
 89.2
Larval Malpighian Tubules
 
 57.3
Larval Fat Body
 
 67.2
Larval Salivary Gland
 
 113.8
Larval Trachea
 
 147.85
Larval Carcass
 
 105.3
Adult Head
 
 41.9
Adult Eye
 
 31.525
Adult Brain
 
 64.6
Adult Thoracic-Abdominal Ganglion
 
 57.2
Adult Crop
 
 44.6
Adult Midgut no informative data
Adult Hindgut
 
 50.9
Adult Malpighian Tubules no informative data
Adult Fat Body no informative data
Adult Salivary Gland no informative data
Adult Heart
 
 32.875
Adult VirginFemale Spermatheca
 
 34.5
Adult InseminatedFemale Spermatheca
 
 43.1
Adult Ovary
 
 277.2
Adult Testis
 
 120.5
Adult Male Accessory Gland
 
 67.6
Adult Carcass no informative data
Expression Level Scale
 None 
 Low 
 Moderate 
log, scaled to Moderate expression
Tissue   Expression Level
Larval Central Nervous System
 
 218.075
Larval Midgut no informative data
Larval Hindgut
 
 89.2
Larval Malpighian Tubules
 
 57.3
Larval Fat Body
 
 67.2
Larval Salivary Gland
 
 113.8
Larval Trachea
 
 147.85
Larval Carcass
 
 105.3
Adult Head
 
 41.9
Adult Eye
 
 31.525
Adult Brain
 
 64.6
Adult Thoracic-Abdominal Ganglion
 
 57.2
Adult Crop
 
 44.6
Adult Midgut no informative data
Adult Hindgut
 
 50.9
Adult Malpighian Tubules no informative data
Adult Fat Body no informative data
Adult Salivary Gland no informative data
Adult Heart
 
 32.875
Adult VirginFemale Spermatheca
 
 34.5
Adult InseminatedFemale Spermatheca
 
 43.1
Adult Ovary
 
 277.2
Adult Testis
 
 120.5
Adult Male Accessory Gland
 
 67.6
Adult Carcass no informative data
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
log, scaled to High level expression
Tissue   Expression Level
Larval Central Nervous System
 
 218.075
Larval Midgut no informative data
Larval Hindgut
 
 89.2
Larval Malpighian Tubules
 
 57.3
Larval Fat Body
 
 67.2
Larval Salivary Gland
 
 113.8
Larval Trachea
 
 147.85
Larval Carcass
 
 105.3
Adult Head
 
 41.9
Adult Eye
 
 31.525
Adult Brain
 
 64.6
Adult Thoracic-Abdominal Ganglion
 
 57.2
Adult Crop
 
 44.6
Adult Midgut no informative data
Adult Hindgut
 
 50.9
Adult Malpighian Tubules no informative data
Adult Fat Body no informative data
Adult Salivary Gland no informative data
Adult Heart
 
 32.875
Adult VirginFemale Spermatheca
 
 34.5
Adult InseminatedFemale Spermatheca
 
 43.1
Adult Ovary
 
 277.2
Adult Testis
 
 120.5
Adult Male Accessory Gland
 
 67.6
Adult Carcass no informative data
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
log, scaled to Very high expression
Tissue   Expression Level
Larval Central Nervous System
 
 218.075
Larval Midgut no informative data
Larval Hindgut
 
 89.2
Larval Malpighian Tubules
 
 57.3
Larval Fat Body
 
 67.2
Larval Salivary Gland
 
 113.8
Larval Trachea
 
 147.85
Larval Carcass
 
 105.3
Adult Head
 
 41.9
Adult Eye
 
 31.525
Adult Brain
 
 64.6
Adult Thoracic-Abdominal Ganglion
 
 57.2
Adult Crop
 
 44.6
Adult Midgut no informative data
Adult Hindgut
 
 50.9
Adult Malpighian Tubules no informative data
Adult Fat Body no informative data
Adult Salivary Gland no informative data
Adult Heart
 
 32.875
Adult VirginFemale Spermatheca
 
 34.5
Adult InseminatedFemale Spermatheca
 
 43.1
Adult Ovary
 
 277.2
Adult Testis
 
 120.5
Adult Male Accessory Gland
 
 67.6
Adult Carcass no informative data
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
Heatmap
Tissue   Expression Level
Larval Central Nervous System
 
 
Larval Midgut no informative data
Larval Hindgut
 
 
Larval Malpighian Tubules
 
 
Larval Fat Body
 
 
Larval Salivary Gland
 
 
Larval Trachea
 
 
Larval Carcass
 
 
Adult Head
 
 
Adult Eye
 
 
Adult Brain
 
 
Adult Thoracic-Abdominal Ganglion
 
 
Adult Crop
 
 
Adult Midgut no informative data
Adult Hindgut
 
 
Adult Malpighian Tubules no informative data
Adult Fat Body no informative data
Adult Salivary Gland no informative data
Adult Heart
 
 
Adult VirginFemale Spermatheca
 
 
Adult InseminatedFemale Spermatheca
 
 
Adult Ovary
 
 
Adult Testis
 
 
Adult Male Accessory Gland
 
 
Adult Carcass no informative data

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level Tissue Adult Expression Level
 
NA 
Head
 
 41.9
 
NA 
Eye
 
 31.525
 
NA 
Brain
 
 64.6
 
218.075 
Central Nervous System
 
 NA
 
NA 
Thoracic-Abdominal Ganglion
 
 57.2
 
NA 
Crop
 
 44.6
 
no informative data 
Midgut
 
 no informative data
 
89.2 
Hindgut
 
 50.9
 
57.3 
Malpighian Tubules
 
 no informative data
 
67.2 
Fat Body
 
 no informative data
 
113.8 
Salivary Gland
 
 no informative data
 
NA 
Heart
 
 32.875
 
147.85 
Trachea
 
 NA
 
NA 
VirginFemale Spermatheca
 
 34.5
 
NA 
InseminatedFemale Spermatheca
 
 43.1
 
NA 
Ovary
 
 277.2
 
NA 
Testis
 
 120.5
 
NA 
Male Accessory Gland
 
 67.6
 
105.3 
Carcass
 
 no informative data

modENCODE Temporal Expression Data (Graveley et al., 2011)
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
hide Expression Clusters
A cluster of genes with similar mRNA expression dynamics across development.
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FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
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Allele
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Allele
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Allele
hide Classical Alleles ( 8 )
For All Classical Alleles Show

Allele of Nup98-96ClassMutagenStocksKnown lesion
Nup98-96339
1 Yes
Nup98-96G21201 --
Nup98-962288
0 Yes
Nup98-96C14.7
0 --
Nup98-96E53.1
0 Yes
Nup98-96F1.13
0 Yes
Nup98-96F1.15
0 Yes
Nup98-96F8.5
0 Yes
hide Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show

Allele of Nup98-96ClassMutagenStocksKnown lesion
Nup98-96GD68972 Yes
Nup98-96HM050481 Yes
Nup98-96dsRNA.cMa0 Yes
Nup98-96KK1003880 Yes
Nup98-96Scer\UAS.980 Yes
Nup98-96Scer\UAS.cPa0 Yes
hide Aneuploid Aberrations
Disrupted in
Not disrupted in
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Transgenic Constructs
Type of construct
Name
Expression data
Insertions
Type of insertions
Name
Expression data
insertion of mobile activating element
miscellaneous insertions
hide Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
hide Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term
References
Cellular Component ( 0 terms)
hide Terms Based on Predictions or Assertions ( 1 term )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term
References
inferred from sequence or structural similarity with EMBL:AF071076 AND inferred from sequence or structural similarity with UniProtKB:P49793
hide Sequence Ontology: Class of Gene
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Protein-protein
Interacting group
Assay
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Interacts with
Please look at the allele data for full details of the genetic interactions
Nup98-96 allele
Gene
References
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BioGRID - A database of protein and genetic interactions
DroID - A comprehensive database of gene and protein interactions.
InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.
hide Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs
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InParanoid A subset of ortholog calls from InParanoid.
OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs.
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hide Stocks Listed in FlyBase ( 5 )
Bloomington
VDRC
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Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
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Please Note
This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
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DRSC - Results from RNAi screens.
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
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Source for database identity of
Source for database merge of
Source for merge of: CG10198 CG10201
Source for merge of: l(3)95BCd Nup98
Additional comments
FlyBase Curator comment: Correspondence with author Lan Xu revealed that 'nup145' = CG10198.
Source for merge of CG10198 CG10201 was a shared cDNA (date:010720).
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S2 cells treated with dsRNA directed against Nup98 show decreased uptake of S.aureus by phagocytosis compared to control cells.
S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.
Identified as a potential component of the hh signalling pathway in a genome-wide RNAi screen. dsRNA made from templates generated with primers directed affects the extent of expression of a hh signaling reporter construct in Clone 8 cells.
This gene is alternatively transcribed, giving rise to a minor 3.5kb Nup98 transcript and a major 7.3kb Nup98-Nup96 transcript. Which may autoproteolytically cleaves itself yielding separate Nup98 and Nup96 proteins.
Nup98 causes epistatic inviability in hybrids between D.melanogaster and D.simulans.
hide External Crossreferences & Linkouts
Sequence Crossreferences
RefSeq (Transcripts)
RefSeq (Proteins)
Entrez Gene - A searchable database of RefSeq genes.
Other Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
Linkouts
BioGRID - A database of protein and genetic interactions
DroID - A comprehensive database of gene and protein interactions.
DRSC - Results from RNAi screens.
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
InParanoid A subset of ortholog calls from InParanoid.
InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.
modMine - Data generated by the modENCODE project.
OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs.
hide Synonyms & Secondary IDs ( 15 )
Reported As
Symbol Synonym
CG10201
 
Nup98-96
 
Name Synonym
Nucleoporin 98
 
nucleoporin98-96
Nucleoporin 98-96
 
Nup98
 
Secondary FlyBase IDs
  • FBgn0021781
  • FBgn0039119
hide References ( 41 )
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hide Recent research papers ( 6 )
Finan et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(14): 5566--5571
From the Cover: Proteomics approach to study the functions of Drosophila myosin VI through identification of multiple cargo-binding proteins. [FBrf0213355]
Parrott et al., 2011, PLoS ONE 6(9): e25087
Nucleoporin98-96 Function Is Required for Transit Amplification Divisions in the Germ Line of Drosophila melanogaster. [FBrf0216255]
Capelson et al., 2010, Cell 140(3): 372--383
Chromatin-Bound Nuclear Pore Components Regulate Gene Expression in Higher Eukaryotes. [FBrf0209890]
Chen and Xu, 2010, Mol. Cell. Biol. 30(16): 4022--4034
Specific nucleoporin requirement for smad nuclear translocation. [FBrf0211334]
Clark and Aquadro, 2010, Mol. Biol. Evol. 27(5): 1152--1161
A novel method to detect proteins evolving at correlated rates: identifying new functional relationships between coevolving proteins. [FBrf0210693]
Kalverda et al., 2010, Cell 140(3): 360--371
Nucleoporins Directly Stimulate Expression of Developmental and Cell-Cycle Genes Inside the Nucleoplasm. [FBrf0209913]
hide Recent reviews (0)
All reviews listed in FlyBase were published before 2010