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Gene Dmel\Nup98-96

General Information
Symbol	Dmel\Nup98-96	Species	D. melanogaster
Name	Nucleoporin 98-96kD	Annotation symbol	CG10198
Feature type	protein_coding_gene	FlyBase ID	FBgn0039120
Gene Model Status	Current	Stock availability	6 publicly available
Also Known As	Nup98, Nup96, l(3)95BCd
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	95B1-95B5	Sequence location	3R:19,599,947..19,607,343 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Nucleoporin 98-96kD is referred to in FlyBase by the symbol Dmel\Nup98-96 (CG10198, FBgn0039120). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: germ-line stem cell maintenance; SMAD protein import into nucleus; phagocytosis, engulfment. 15 alleles are reported. The phenotypes of these alleles are annotated with: female fusome; nurse cell spectrosome; male germline cell. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Nuclear protein 96; Peptidase S59, nucleoporin. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval salivary gland, larval trachea, adult ovary, adult testis, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1632194_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Nup98. Gene sequence location is 3R:19599947..19607343.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 95B1-95B5   Limits computationally determined from genome sequence between P{PZ}l(3)0468404684 and P{PZ}Atg600096
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Nup98-96 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	The larger Nup98-RA transcript encodes a single, large precursor polyprotein that, in other eukaryotes, and thus presumably in flies, autoproteolytically cleaves itself between residues Phe1028 and Ser1029, yielding separate Nup98 and Nup96 proteins (FBrf0159638). Gene model reviewed during 5.41 Gene model reviewed during 5.47
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Nup98-96-RA FBtr0084460  NM_142930   6624   1960 Nup98-96-RC FBtr0304567  NM_001260337   3987   1179 Nup98-96-RD FBtr0334894  NM_001275956   6412   1960
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Nup98-96-PA   FBpp0083851   210.1   1960   6.50     NP_651187   AAF56190 Nup98-96-PC   FBpp0293109   121.6   1179   6.47     NP_001247266   AFH06584 Nup98-96-PD   FBpp0306915   210.1   1960   6.50     NP_001262885   AGB96265
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Peptidase S59, nucleoporin (IPR007230) Nuclear protein 96 (IPR021967)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA390577   AA390606   AA392158   AA438836   AA440511   AA539270   AA694787   AA696859   AA801555   AA820976   AA941772   AA950532   AA950681   AE014297 AAF56190   AE014297 AFH06584   AE014297 AGB96265   AI456395   AI515774   AI515795   AI516387   AI519590   AI532857   AI542148   AI542372   AI546649   AW944554   AY250769 AAP13264   AY250770 AAP13266   AY250771 AAP13265   AY250772 AAP13267   AY250773 AAP13268   AY250774 AAP13269   AY250775 AAP13270   AY250776 AAP13271   AY250777 AAP13272   AY250778 AAP13273   AY250779 AAP13274   AY250780 AAP13275   AY250781 AAP13276   AY250782 AAP13277   AY250783 AAP13278   BF485591   BF486166   BF490143   BF493028   BF493029   BF498191   BF504079   BF505261   BF505742   BG638180   BG639010   BI230973   BI352015   BI370332   BT011076   BT056313   CK658004   CO153502   CO155990   CO189209   CO272942   CO275618   CO279924   CO294275   CO336996   CO338515   CO338630   EC059908   EC200257   EC216430   EC229819   EC235921   EC243792   EC261686   EC261809   EC266939   EC267568   EF057947 ABL84882   EF057948 ABL84883   EF057949 ABL84884   EF057950 ABL84885   EF057951 ABL84886   EF057952 ABL84887   EF057953 ABL84888   EF057954 ABL84889   EF057955 ABL84890   EF057956 ABL84891   EF057957 ABL84892   EF057958 ABL84893   EF057959 ABL84894   EF057960 ABL84895   EF057961 ABL84896   EL882236   EL882237   ES690236   GH738854   GH774023   GH777462   GH813174   GH847315
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VCH5 Q867M7 Q86G43 A1YK35 A1YK27 Q867W7 Q867M2 A1YK25 A1YK38 Q867H5 A1YK24 A1YK33 Q868A8 A1YK36
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
nuclear pore inferred from physical interaction with Rae1 (Tian et al., 2011)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval salivary gland, larval trachea, adult ovary, adult testis, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    218.075 Larval Midgut    49.4 Larval Hindgut    89.2 Larval Malpighian Tubules    57.3 Larval Fat Body    67.2 Larval Salivary Gland    113.8 Larval Trachea    147.85 Larval Carcass    105.3 Adult Head    41.9 Adult Eye    31.525 Adult Brain    64.6 Adult Thoracic-Abdominal Ganglion    57.2 Adult Crop    44.6 Adult Midgut    41 Adult Hindgut    50.9 Adult Malpighian Tubules    50.3 Adult Fat Body    55.1 Adult Salivary Gland    50.7 Adult Heart    32.875 Adult VirginFemale Spermatheca    34.5 Adult InseminatedFemale Spermatheca    43.1 Adult Ovary    277.2 Adult Testis    120.5 Adult Male Accessory Gland    67.6 Adult Carcass    48.6 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    218.075 Larval Midgut    49.4 Larval Hindgut    89.2 Larval Malpighian Tubules    57.3 Larval Fat Body    67.2 Larval Salivary Gland    113.8 Larval Trachea    147.85 Larval Carcass    105.3 Adult Head    41.9 Adult Eye    31.525 Adult Brain    64.6 Adult Thoracic-Abdominal Ganglion    57.2 Adult Crop    44.6 Adult Midgut    41 Adult Hindgut    50.9 Adult Malpighian Tubules    50.3 Adult Fat Body    55.1 Adult Salivary Gland    50.7 Adult Heart    32.875 Adult VirginFemale Spermatheca    34.5 Adult InseminatedFemale Spermatheca    43.1 Adult Ovary    277.2 Adult Testis    120.5 Adult Male Accessory Gland    67.6 Adult Carcass    48.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    218.075 Larval Midgut    49.4 Larval Hindgut    89.2 Larval Malpighian Tubules    57.3 Larval Fat Body    67.2 Larval Salivary Gland    113.8 Larval Trachea    147.85 Larval Carcass    105.3 Adult Head    41.9 Adult Eye    31.525 Adult Brain    64.6 Adult Thoracic-Abdominal Ganglion    57.2 Adult Crop    44.6 Adult Midgut    41 Adult Hindgut    50.9 Adult Malpighian Tubules    50.3 Adult Fat Body    55.1 Adult Salivary Gland    50.7 Adult Heart    32.875 Adult VirginFemale Spermatheca    34.5 Adult InseminatedFemale Spermatheca    43.1 Adult Ovary    277.2 Adult Testis    120.5 Adult Male Accessory Gland    67.6 Adult Carcass    48.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    218.075 Larval Midgut    49.4 Larval Hindgut    89.2 Larval Malpighian Tubules    57.3 Larval Fat Body    67.2 Larval Salivary Gland    113.8 Larval Trachea    147.85 Larval Carcass    105.3 Adult Head    41.9 Adult Eye    31.525 Adult Brain    64.6 Adult Thoracic-Abdominal Ganglion    57.2 Adult Crop    44.6 Adult Midgut    41 Adult Hindgut    50.9 Adult Malpighian Tubules    50.3 Adult Fat Body    55.1 Adult Salivary Gland    50.7 Adult Heart    32.875 Adult VirginFemale Spermatheca    34.5 Adult InseminatedFemale Spermatheca    43.1 Adult Ovary    277.2 Adult Testis    120.5 Adult Male Accessory Gland    67.6 Adult Carcass    48.6 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    218.075 Larval Midgut    49.4 Larval Hindgut    89.2 Larval Malpighian Tubules    57.3 Larval Fat Body    67.2 Larval Salivary Gland    113.8 Larval Trachea    147.85 Larval Carcass    105.3 Adult Head    41.9 Adult Eye    31.525 Adult Brain    64.6 Adult Thoracic-Abdominal Ganglion    57.2 Adult Crop    44.6 Adult Midgut    41 Adult Hindgut    50.9 Adult Malpighian Tubules    50.3 Adult Fat Body    55.1 Adult Salivary Gland    50.7 Adult Heart    32.875 Adult VirginFemale Spermatheca    34.5 Adult InseminatedFemale Spermatheca    43.1 Adult Ovary    277.2 Adult Testis    120.5 Adult Male Accessory Gland    67.6 Adult Carcass    48.6 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    218.075 Larval Midgut    49.4 Larval Hindgut    89.2 Larval Malpighian Tubules    57.3 Larval Fat Body    67.2 Larval Salivary Gland    113.8 Larval Trachea    147.85 Larval Carcass    105.3 Adult Head    41.9 Adult Eye    31.525 Adult Brain    64.6 Adult Thoracic-Abdominal Ganglion    57.2 Adult Crop    44.6 Adult Midgut    41 Adult Hindgut    50.9 Adult Malpighian Tubules    50.3 Adult Fat Body    55.1 Adult Salivary Gland    50.7 Adult Heart    32.875 Adult VirginFemale Spermatheca    34.5 Adult InseminatedFemale Spermatheca    43.1 Adult Ovary    277.2 Adult Testis    120.5 Adult Male Accessory Gland    67.6 Adult Carcass    48.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    218.075 Larval Midgut    49.4 Larval Hindgut    89.2 Larval Malpighian Tubules    57.3 Larval Fat Body    67.2 Larval Salivary Gland    113.8 Larval Trachea    147.85 Larval Carcass    105.3 Adult Head    41.9 Adult Eye    31.525 Adult Brain    64.6 Adult Thoracic-Abdominal Ganglion    57.2 Adult Crop    44.6 Adult Midgut    41 Adult Hindgut    50.9 Adult Malpighian Tubules    50.3 Adult Fat Body    55.1 Adult Salivary Gland    50.7 Adult Heart    32.875 Adult VirginFemale Spermatheca    34.5 Adult InseminatedFemale Spermatheca    43.1 Adult Ovary    277.2 Adult Testis    120.5 Adult Male Accessory Gland    67.6 Adult Carcass    48.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    218.075 Larval Midgut    49.4 Larval Hindgut    89.2 Larval Malpighian Tubules    57.3 Larval Fat Body    67.2 Larval Salivary Gland    113.8 Larval Trachea    147.85 Larval Carcass    105.3 Adult Head    41.9 Adult Eye    31.525 Adult Brain    64.6 Adult Thoracic-Abdominal Ganglion    57.2 Adult Crop    44.6 Adult Midgut    41 Adult Hindgut    50.9 Adult Malpighian Tubules    50.3 Adult Fat Body    55.1 Adult Salivary Gland    50.7 Adult Heart    32.875 Adult VirginFemale Spermatheca    34.5 Adult InseminatedFemale Spermatheca    43.1 Adult Ovary    277.2 Adult Testis    120.5 Adult Male Accessory Gland    67.6 Adult Carcass    48.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    41.9   NA  Eye    31.525   NA  Brain    64.6   218.075  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    57.2   NA  Crop    44.6   no informative data  Midgut    no informative data   89.2  Hindgut    50.9   57.3  Malpighian Tubules    no informative data   67.2  Fat Body    no informative data   113.8  Salivary Gland    no informative data   NA  Heart    32.875   147.85  Trachea    NA   NA  VirginFemale Spermatheca    34.5   NA  InseminatedFemale Spermatheca    43.1   NA  Ovary    277.2   NA  Testis    120.5   NA  Male Accessory Gland    67.6   105.3  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    29 central nervous system, larvae L3    18 central nervous system, pupae P8    7 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    6 head, mated 1-day female    3 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    5 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    2 fat body, white prepupae    6 fat body, pupae P8    4 carcass, larvae L3 wandering    15 carcass, 1-day adult    4 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    58 ovary, mated 4-day female    46 testis, mated 4-day male    17 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (29) central nervous system, larvae L3    18 central nervous system, pupae P8    7 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    6 head, mated 1-day female    3 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    5 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    2 fat body, white prepupae    6 fat body, pupae P8    4 carcass, larvae L3 wandering    15 carcass, 1-day adult    4 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female  (58) ovary, mated 4-day female  (46) testis, mated 4-day male    17 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    29 central nervous system, larvae L3    18 central nervous system, pupae P8    7 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    6 head, mated 1-day female    3 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    5 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    2 fat body, white prepupae    6 fat body, pupae P8    4 carcass, larvae L3 wandering    15 carcass, 1-day adult    4 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    58 ovary, mated 4-day female    46 testis, mated 4-day male    17 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    29 central nervous system, larvae L3    18 central nervous system, pupae P8    7 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    6 head, mated 1-day female    3 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    5 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    2 fat body, white prepupae    6 fat body, pupae P8    4 carcass, larvae L3 wandering    15 carcass, 1-day adult    4 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    58 ovary, mated 4-day female    46 testis, mated 4-day male    17 accessory gland, mated 4-day male    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    29 central nervous system, larvae L3    18 central nervous system, pupae P8    7 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    6 head, mated 1-day female    3 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    5 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    2 fat body, white prepupae    6 fat body, pupae P8    4 carcass, larvae L3 wandering    15 carcass, 1-day adult    4 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    58 ovary, mated 4-day female    46 testis, mated 4-day male    17 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  29 central nervous system, larvae L3    18 central nervous system, pupae P8    7 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    6 head, mated 1-day female    3 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    5 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    2 fat body, white prepupae    6 fat body, pupae P8    4 carcass, larvae L3 wandering    15 carcass, 1-day adult    4 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female  (58) ovary, mated 4-day female  (46) testis, mated 4-day male    17 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    29 central nervous system, larvae L3    18 central nervous system, pupae P8    7 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    6 head, mated 1-day female    3 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    5 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    2 fat body, white prepupae    6 fat body, pupae P8    4 carcass, larvae L3 wandering    15 carcass, 1-day adult    4 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    58 ovary, mated 4-day female    46 testis, mated 4-day male    17 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    29 central nervous system, larvae L3    18 central nervous system, pupae P8    7 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    6 head, mated 1-day female    3 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    5 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    2 fat body, white prepupae    6 fat body, pupae P8    4 carcass, larvae L3 wandering    15 carcass, 1-day adult    4 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    58 ovary, mated 4-day female    46 testis, mated 4-day male    17 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    66 embryo 02-04hr    49 embryo 04-06hr    63 embryo 06-08hr    47 embryo 08-10hr    38 embryo 10-12hr    21 embryo 12-14hr    20 embryo 14-16hr    16 embryo 16-18hr    13 embryo 18-20hr    8 embryo 20-22hr    10 embryo 22-24hr    11 larva L1    16 larva L2    14 larva L3 12hr old    12 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    16 white prepupae 12hr    18 white prepupae 24hr    21 pupae 2d postWPP    14 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    11 adult male 05day    15 adult male 30day    14 adult female 01day    22 adult female 05day    44 adult female 30day    43 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (66) embryo 02-04hr  (49) embryo 04-06hr  (63) embryo 06-08hr  (47) embryo 08-10hr  (38) embryo 10-12hr    21 embryo 12-14hr    20 embryo 14-16hr    16 embryo 16-18hr    13 embryo 18-20hr    8 embryo 20-22hr    10 embryo 22-24hr    11 larva L1    16 larva L2    14 larva L3 12hr old    12 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    16 white prepupae 12hr    18 white prepupae 24hr    21 pupae 2d postWPP    14 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    11 adult male 05day    15 adult male 30day    14 adult female 01day    22 adult female 05day  (44) adult female 30day  (43) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    66 embryo 02-04hr    49 embryo 04-06hr    63 embryo 06-08hr    47 embryo 08-10hr    38 embryo 10-12hr    21 embryo 12-14hr    20 embryo 14-16hr    16 embryo 16-18hr    13 embryo 18-20hr    8 embryo 20-22hr    10 embryo 22-24hr    11 larva L1    16 larva L2    14 larva L3 12hr old    12 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    16 white prepupae 12hr    18 white prepupae 24hr    21 pupae 2d postWPP    14 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    11 adult male 05day    15 adult male 30day    14 adult female 01day    22 adult female 05day    44 adult female 30day    43 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    66 embryo 02-04hr    49 embryo 04-06hr    63 embryo 06-08hr    47 embryo 08-10hr    38 embryo 10-12hr    21 embryo 12-14hr    20 embryo 14-16hr    16 embryo 16-18hr    13 embryo 18-20hr    8 embryo 20-22hr    10 embryo 22-24hr    11 larva L1    16 larva L2    14 larva L3 12hr old    12 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    16 white prepupae 12hr    18 white prepupae 24hr    21 pupae 2d postWPP    14 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    11 adult male 05day    15 adult male 30day    14 adult female 01day    22 adult female 05day    44 adult female 30day    43 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    66 embryo 02-04hr    49 embryo 04-06hr    63 embryo 06-08hr    47 embryo 08-10hr    38 embryo 10-12hr    21 embryo 12-14hr    20 embryo 14-16hr    16 embryo 16-18hr    13 embryo 18-20hr    8 embryo 20-22hr    10 embryo 22-24hr    11 larva L1    16 larva L2    14 larva L3 12hr old    12 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    16 white prepupae 12hr    18 white prepupae 24hr    21 pupae 2d postWPP    14 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    11 adult male 05day    15 adult male 30day    14 adult female 01day    22 adult female 05day    44 adult female 30day    43 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (66) embryo 02-04hr  (49) embryo 04-06hr  (63) embryo 06-08hr  (47) embryo 08-10hr  (38) embryo 10-12hr    21 embryo 12-14hr    20 embryo 14-16hr    16 embryo 16-18hr    13 embryo 18-20hr    8 embryo 20-22hr    10 embryo 22-24hr    11 larva L1    16 larva L2    14 larva L3 12hr old    12 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    16 white prepupae 12hr    18 white prepupae 24hr    21 pupae 2d postWPP    14 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    11 adult male 05day    15 adult male 30day    14 adult female 01day    22 adult female 05day  (44) adult female 30day  (43) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    66 embryo 02-04hr    49 embryo 04-06hr    63 embryo 06-08hr    47 embryo 08-10hr    38 embryo 10-12hr    21 embryo 12-14hr    20 embryo 14-16hr    16 embryo 16-18hr    13 embryo 18-20hr    8 embryo 20-22hr    10 embryo 22-24hr    11 larva L1    16 larva L2    14 larva L3 12hr old    12 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    16 white prepupae 12hr    18 white prepupae 24hr    21 pupae 2d postWPP    14 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    11 adult male 05day    15 adult male 30day    14 adult female 01day    22 adult female 05day    44 adult female 30day    43 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    66 embryo 02-04hr    49 embryo 04-06hr    63 embryo 06-08hr    47 embryo 08-10hr    38 embryo 10-12hr    21 embryo 12-14hr    20 embryo 14-16hr    16 embryo 16-18hr    13 embryo 18-20hr    8 embryo 20-22hr    10 embryo 22-24hr    11 larva L1    16 larva L2    14 larva L3 12hr old    12 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    17 white prepupae new    16 white prepupae 12hr    18 white prepupae 24hr    21 pupae 2d postWPP    14 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    11 adult male 05day    15 adult male 30day    14 adult female 01day    22 adult female 05day    44 adult female 30day    43 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    36 Schneider line 2 Sg4    23 embryonic 1182-4H    32 embryonic GM2    43 embryonic Kc167    39 embryonic S1    43 embryonic S3    35 leg disc CME L1    23 wing disc CME-W2    30 wing disc ML-DmD8    25 wing disc ML-DmD9    30 wing disc ML-DmD16-c3    30 wing disc ML-DmD21    13 wing disc ML-DmD32    22 haltere disc ML-DmD17-c3    48 eye-antennal disc ML-DmD11    36 antennal disc ML-DmD20-c5    28 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    29 CNS ML-DmBG2-c2    26 tumorous blood cells mbn2    30 ovary fGS/OSS    57 ovary OSC    59 ovary OSS    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (36) Schneider line 2 Sg4    23 embryonic 1182-4H  (32) embryonic GM2  (43) embryonic Kc167  (39) embryonic S1  (43) embryonic S3  (35) leg disc CME L1    23 wing disc CME-W2  (30) wing disc ML-DmD8    25 wing disc ML-DmD9  (30) wing disc ML-DmD16-c3  (30) wing disc ML-DmD21    13 wing disc ML-DmD32    22 haltere disc ML-DmD17-c3  (48) eye-antennal disc ML-DmD11  (36) antennal disc ML-DmD20-c5  (28) mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1  (29) CNS ML-DmBG2-c2  26 tumorous blood cells mbn2  (30) ovary fGS/OSS  (57) ovary OSC  (59) ovary OSS    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    36 Schneider line 2 Sg4    23 embryonic 1182-4H    32 embryonic GM2    43 embryonic Kc167    39 embryonic S1    43 embryonic S3    35 leg disc CME L1    23 wing disc CME-W2    30 wing disc ML-DmD8    25 wing disc ML-DmD9    30 wing disc ML-DmD16-c3    30 wing disc ML-DmD21    13 wing disc ML-DmD32    22 haltere disc ML-DmD17-c3    48 eye-antennal disc ML-DmD11    36 antennal disc ML-DmD20-c5    28 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    29 CNS ML-DmBG2-c2    26 tumorous blood cells mbn2    30 ovary fGS/OSS    57 ovary OSC    59 ovary OSS    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    36 Schneider line 2 Sg4    23 embryonic 1182-4H    32 embryonic GM2    43 embryonic Kc167    39 embryonic S1    43 embryonic S3    35 leg disc CME L1    23 wing disc CME-W2    30 wing disc ML-DmD8    25 wing disc ML-DmD9    30 wing disc ML-DmD16-c3    30 wing disc ML-DmD21    13 wing disc ML-DmD32    22 haltere disc ML-DmD17-c3    48 eye-antennal disc ML-DmD11    36 antennal disc ML-DmD20-c5    28 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    29 CNS ML-DmBG2-c2    26 tumorous blood cells mbn2    30 ovary fGS/OSS    57 ovary OSC    59 ovary OSS    20 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    36 Schneider line 2 Sg4    23 embryonic 1182-4H    32 embryonic GM2    43 embryonic Kc167    39 embryonic S1    43 embryonic S3    35 leg disc CME L1    23 wing disc CME-W2    30 wing disc ML-DmD8    25 wing disc ML-DmD9    30 wing disc ML-DmD16-c3    30 wing disc ML-DmD21    13 wing disc ML-DmD32    22 haltere disc ML-DmD17-c3    48 eye-antennal disc ML-DmD11    36 antennal disc ML-DmD20-c5    28 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    29 CNS ML-DmBG2-c2    26 tumorous blood cells mbn2    30 ovary fGS/OSS    57 ovary OSC    59 ovary OSS    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (36) Schneider line 2 Sg4    23 embryonic 1182-4H  32 embryonic GM2  (43) embryonic Kc167  (39) embryonic S1  (43) embryonic S3  (35) leg disc CME L1    23 wing disc CME-W2  30 wing disc ML-DmD8    25 wing disc ML-DmD9  30 wing disc ML-DmD16-c3  30 wing disc ML-DmD21    13 wing disc ML-DmD32    22 haltere disc ML-DmD17-c3  (48) eye-antennal disc ML-DmD11  (36) antennal disc ML-DmD20-c5  28 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1  29 CNS ML-DmBG2-c2  26 tumorous blood cells mbn2  30 ovary fGS/OSS  (57) ovary OSC  (59) ovary OSS    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    36 Schneider line 2 Sg4    23 embryonic 1182-4H    32 embryonic GM2    43 embryonic Kc167    39 embryonic S1    43 embryonic S3    35 leg disc CME L1    23 wing disc CME-W2    30 wing disc ML-DmD8    25 wing disc ML-DmD9    30 wing disc ML-DmD16-c3    30 wing disc ML-DmD21    13 wing disc ML-DmD32    22 haltere disc ML-DmD17-c3    48 eye-antennal disc ML-DmD11    36 antennal disc ML-DmD20-c5    28 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    29 CNS ML-DmBG2-c2    26 tumorous blood cells mbn2    30 ovary fGS/OSS    57 ovary OSC    59 ovary OSS    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    36 Schneider line 2 Sg4    23 embryonic 1182-4H    32 embryonic GM2    43 embryonic Kc167    39 embryonic S1    43 embryonic S3    35 leg disc CME L1    23 wing disc CME-W2    30 wing disc ML-DmD8    25 wing disc ML-DmD9    30 wing disc ML-DmD16-c3    30 wing disc ML-DmD21    13 wing disc ML-DmD32    22 haltere disc ML-DmD17-c3    48 eye-antennal disc ML-DmD11    36 antennal disc ML-DmD20-c5    28 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    29 CNS ML-DmBG2-c2    26 tumorous blood cells mbn2    30 ovary fGS/OSS    57 ovary OSC    59 ovary OSS    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    6 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    41 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    32 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    28 Paraquat 10 mM 48 hrs, 4-day adult    30 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    6 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult  (38) Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3  (41) Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (32) Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult  (28) Paraquat 10 mM 48 hrs, 4-day adult  (30) Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    6 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    41 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    32 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    28 Paraquat 10 mM 48 hrs, 4-day adult    30 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    6 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    41 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    32 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    28 Paraquat 10 mM 48 hrs, 4-day adult    30 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    6 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    41 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    32 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    28 Paraquat 10 mM 48 hrs, 4-day adult    30 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    6 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult  (38) Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3  (41) Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  32 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult  28 Paraquat 10 mM 48 hrs, 4-day adult  30 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    6 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    41 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    32 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    28 Paraquat 10 mM 48 hrs, 4-day adult    30 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    6 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    41 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    32 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    28 Paraquat 10 mM 48 hrs, 4-day adult    30 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_13
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039120 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10198-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4pnr-MD237 Nup98-96GD6897 lethal | recessive Nup98-96339 Other Phenotypes Allele cell growth defective Nup98-96dsRNA.cMa Phenotype manifest in Allele female fusome Nup98-962288 female fusome (with Df(3R)mbc-R1) Nup98-962288 female germline cell | adult stage (with Df(3R)mbc-R1) Nup98-962288 male fusome | adult stage (with Df(3R)mbc-R1) Nup98-962288 male fusome | third instar larval stage (with Df(3R)mbc-R1) Nup98-962288 male germline cell, with Scer\GAL4nos.UTR.T:Hsim\VP16 Nup98-96GD6897 male germline cell | adult stage (with Df(3R)mbc-R1) Nup98-962288 male germline stem cell | third instar larval stage (with Df(3R)mbc-R1) Nup98-962288 nurse cell spectrosome Nup98-962288 nurse cell spectrosome (with Df(3R)mbc-R1) Nup98-962288 primary gonial cell | third instar larval stage (with Df(3R)mbc-R1) Nup98-962288 spermatogonium | third instar larval stage (with Df(3R)mbc-R1) Nup98-962288
Classical Alleles ( 8 )
For All Classical Alleles Show
Allele of Nup98-96 Class Mutagen Stocks Known lesion Nup98-96339 2 Yes Nup98-96G2120 P-element activity 1 -- Nup98-962288 0 Yes Nup98-96C14.7 0 -- Nup98-96E53.1 0 Yes Nup98-96F1.13 0 Yes Nup98-96F1.15 0 Yes Nup98-96F8.5 0 Yes
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Nup98-96 Class Mutagen Stocks Known lesion Nup98-96GD6897 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Nup98-96HM05048 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Nup98-96dsRNA.cMa in vitro construct - RNAi 0 Yes Nup98-96KK100388 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Nup98-96NIG.10198R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Nup98-96Scer\UAS.98 in vitro construct - deletion 0 Yes Nup98-96Scer\UAS.cPa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)CA15 (Erickson et al., 1997) Df(3R)Exel9013 (Ryder, 2004.4.26) Df(3R)Exel9014 (Ryder, 2004.4.26) Df(3R)mbc-15A (Presgraves et al., 2003, Erickson et al., 1997) Df(3R)mbc-30 (Keller et al., 1998, Presgraves et al., 2003, Erickson et al., 1997, Parrott et al., 2011) Df(3R)mbc-BG1 (Presgraves et al., 2003) Df(3R)mbc-F5.3 (Presgraves et al., 2003, Erickson et al., 1997) Df(3R)mbc-R1 (Presgraves et al., 2003, Parrott et al., 2011) Df(3R)mbc-R.1 (Erickson et al., 1997) Df(3R)nau-9 (Keller et al., 1998, Presgraves et al., 2003) Df(3R)γ20 (Keller et al., 1998)
Not disrupted in	Df(3R)CA (Keller et al., 1998, Presgraves et al., 2003) Df(3R)CA2 (Erickson et al., 1997) Df(3R)nau-4A (Keller et al., 1998, Presgraves et al., 2003) Df(3R)nau-11a4 (Keller et al., 1998, Presgraves et al., 2003)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{NIG.10198R} NA P{UAS-Nup98-96.P} NA P{UAS-Nup98.P} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}Nup98-96G2120 NA miscellaneous insertions pogo{}Nup98-962288 NA
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with Rae1 (Tian et al., 2011) inferred from physical interaction with UniProtKB:Q9VKJ3 (assigned by UniProtKB) (Tang and Presgraves, 2009)
Biological Process
CV term Evidence References
germ-line stem cell maintenance inferred from mutant phenotype (Parrott et al., 2011) phagocytosis, engulfment inferred from mutant phenotype (Stroschein-Stevenson et al., 2006) SMAD protein import into nucleus inferred from mutant phenotype (Chen and Xu, 2010)
Cellular Component
CV term Evidence References
nuclear pore inferred from physical interaction with Rae1 (Tian et al., 2011)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
nucleocytoplasmic transporter activity inferred from sequence or structural similarity with Saccharomyces NUP100 (Curators, 2008--)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
nuclear pore inferred from sequence or structural similarity with EMBL:AF071076 AND inferred from sequence or structural similarity with UniProtKB:P49793 (FlyBase, 1992-) nuclear pore central transport channel inferred from sequence or structural similarity with Saccharomyces NUP100 (Curators, 2008--)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Nup98-96 - CG11876 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nup98-96 - HPS1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nup98-96 - Nup107 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Nup98-96 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67753 DroID - A comprehensive database of gene and protein interactions. • FBgn0039120 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42816
Orthologs
OrthoDB Orthologs (46) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6Z8ZFV Dipteran inclusive ortholog search EOG63FH4W Insect inclusive ortholog search EOG6JSZ19 Arthropod inclusive ortholog search EOG6866TB Metazoa inclusive ortholog search EOG62RS0Z
Orthologs in Drosophila Species (EOG6Z8ZFV)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Nup98-96     Drosophila simulans   Dsim\Nup98 Y   Drosophila sechellia   Dsec\GM23537 Y   Drosophila erecta   Dere\GG12402 Y   Drosophila yakuba   Dyak\GE23921 Y   Drosophila ananassae   Dana\GF18736 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA10149 Y   Drosophila persimilis   Dper\GL19888     Drosophila persimilis   Dper\GL24268 Y   Drosophila willistoni   Dwil\GK13519 Y   Drosophila virilis   Dvir\GJ24642 Y   Drosophila mojavensis   Dmoj\GI24505 Y   Drosophila grimshawi   Dgri\GH10992 Y   Drosophila grimshawi   Dgri\GH23379
Orthologs in non-Drosophila Dipterans (EOG63FH4W)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL007586   Anopheles gambiae Malaria mosquito  Agam\AGAP002351   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ002761
Orthologs in non-Dipteran Insects (EOG6JSZ19)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB43238   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG015889   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG029478   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG031264   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH26025   Atta cephalotes Leafcutter ant  Acep\ACEP19814   Camponotus floridanus Florida carpenter ant  Cflo\CFLO23081   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL21585   Linepithema humile Argentine ant  Lhum\LH14813   Pogonomyrmex barbatus Red harvester ant  Pbar\PB24904   Solenopsis invicta Red fire ant  Sinv\SINV20541   Solenopsis invicta Red fire ant  Sinv\SINV20540   Acyrthosiphon pisum Pea aphid  Apim\ACYPI001279   Bombyx mori Silkmoth  Bmor\BGIBMGA001818   Pediculus humanus Human body louse  Phum\PHUM598450   Tribolium castaneum Red flour beetle  Tcas\TC013629
Orthologs in non-Insect Arthropods (EOG6866TB)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_118557   Daphnia pulex Water flea  Dpux\JGI_V11_198208   Daphnia pulex Water flea  Dpux\Fn1   Ixodes scapularis Deer tick  Isca\ISCW013985
Orthologs in non-Arthropod Metazoa (EOG62RS0Z)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\ZK328.5   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_012900gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_009213gn   Danio rerio Zebrafish  Drer\nup98   Xenopus tropicalis Western clawed frog  Xtro\nup98   Gallus gallus Domestic chicken  Ggal\NUP98   Mus musculus House mouse  Mmus\Nup98   Rattus norvegicus Norway rat  Rnor\Nup98   Homo sapiens Human  Hsap\ENSG00000110713
Human Orthologs (1)
Gene OMIM HGNC Hsap\ENSG00000110713
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\Nup98 Drosophila sechellia Dsec\GM23537 Drosophila erecta Dere\GG12402 Drosophila yakuba Dyak\GE23921 Drosophila ananassae Dana\GF18736 Drosophila pseudoobscura pseudoobscura Dpse\GA10149 Drosophila persimilis Dper\GL24268 Drosophila willistoni Dwil\GK13519 Drosophila virilis Dvir\GJ24642 Drosophila mojavensis Dmoj\GI24505 Drosophila grimshawi Dgri\GH10992
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	4951 Nup98-96339/TM3, Sb1 28562 y1 v1; P{TRiP.HM05048}attP2 28433 y1 w*; P{EP}Nup98-96G2120/TM3, Sb1 Ser1
Kyoto	107965 Nup98-96339/TM3, Sb1
VDRC	v31198 w1118; P{GD6897}v31198 v31199 w1118; P{GD6897}v31199
Genomic Clones ( 1 )
	BACR11E07 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 62 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE74545 SD08263
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT05364 AT07449 AT08029 AT12565 AT19515 AT20377 AT26440 GM01543 GM08563 GM17245 HL06651 LD09476 LD09677 LD11041 LD13201 LD14529 LD24940 LD25956 LD30367 LD30635 LD36408 LD39229 LD41466 LD42241 LP14480 RE16647 RE56809 SD04491 SD08666 SD09825
Other clones	9848 58218 76588 194857 522478 527036 562055 572861 AT01311 CK01.53D.G7 CK01.141D.F4 EK043428 EK108924 EK118054 EK136409 EK206458 EN02115 EN07150 EN13628 EN17004 EN17229 IP11993 LD18952 LD41443 RC0-DA0007-130700-013-E07 RP01313 RP003117421 RP003126206 RP003215536 RP003639413
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0039120 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42816
Antibody Information
	polyclonal (Parrott et al., 2011)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG10198 CG10201 (FlyBase, 1996-) Source for merge of: l(3)95BCd Nup98 (Presgraves et al., 2003)
Additional comments	FlyBase Curator comment: Correspondence with author Lan Xu revealed that 'nup145' = CG10198. (Chen and Xu, 2010) Source for merge of CG10198 CG10201 was a shared cDNA (date:010720). (FlyBase, 1996-)
Other Comments
	S2 cells treated with dsRNA directed against Nup98 show decreased uptake of S.aureus by phagocytosis compared to control cells. (Stuart et al., 2007) S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells. (Stroschein-Stevenson et al., 2006) Identified as a potential component of the hh signalling pathway in a genome-wide RNAi screen. dsRNA made from templates generated with primers directed affects the extent of expression of a hh signaling reporter construct in Clone 8 cells. (Nybakken et al., 2005) This gene is alternatively transcribed, giving rise to a minor 3.5kb Nup98 transcript and a major 7.3kb Nup98-Nup96 transcript. Which may autoproteolytically cleaves itself yielding separate Nup98 and Nup96 proteins. (Presgraves et al., 2003) Nup98 causes epistatic inviability in hybrids between D.melanogaster and D.simulans. (Presgraves et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_142930 NM_001260337 NM_001275956 RefSeq (Proteins) • NP_651187 NP_001247266 NP_001262885 DDBJ / EMBL / GenBank • AAF56190 AAP13264 AAP13265 AAP13266 AAP13267 AAP13268 AAP13269 AAP13270 AAP13271 AAP13272 AAP13273 AAP13274 AAP13275 AAP13276 AAP13277 AAP13278 ABL84882 ABL84883 ABL84884 ABL84885 ABL84886 ABL84887 ABL84888 ABL84889 ABL84890 ABL84891 ABL84892 ABL84893 ABL84894 ABL84895 ABL84896 AFH06584 AGB96265 AI542148 AW944554 AY250769 AY250770 AY250771 AY250772 AY250773 AY250774 AY250775 AY250776 AY250777 AY250778 AY250779 AY250780 AY250781 AY250782 AY250783 EF057947 EF057948 EF057949 EF057950 EF057951 EF057952 EF057953 EF057954 EF057955 EF057956 EF057957 EF057958 EF057959 EF057960 EF057961 Entrez Gene - A searchable database of RefSeq genes. • 42816 UniProtKB/TrEMBL • A1YK24 A1YK25 A1YK27 A1YK33 A1YK35 A1YK36 A1YK38 Q9VCH5 Q86G43 Q867H5 Q867M2 Q867M7 Q867W7 Q868A8
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Peptidase S59, nucleoporin (IPR007230) Nuclear protein 96 (IPR021967)
Linkouts
	BioGRID - A database of protein and genetic interactions • 67753 DroID - A comprehensive database of gene and protein interactions. • FBgn0039120 DRSC - Results from RNAi screens. • FBgn0039120 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039120 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10198-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0039120 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42816 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42816 modMine - Data generated by the modENCODE project. • FBgn0039120
Synonyms & Secondary IDs ( 18 )
Reported As
Symbol Synonym	CG10198 (Presgraves et al., 2003, Giot et al., 2003, Stuart et al., 2007, Nybakken et al., 2005, Perkins et al., 2009, Keleman et al., 2009.8.5, Sabri et al., 2007) CG10201   l(3)95BCd (Bloomington Drosophila Stock Center, 1999.6.28, Keller et al., 1998, Erickson et al., 1997, ) Nup96 (Albert, 2005, Orr, 2005, Orr et al., 2004, Swanson, 2003, Presgraves et al., 2003, Presgraves and Stephan, 2007, Pennisi, 2006, Barbash, 2007, Capelson et al., 2010) Nup 96 (Clark and Aquadro, 2010) Nup96-98 (Neumann et al., 2010) Nup98 (Finan et al., 2011, Mendjan et al., 2006, Presgraves and Stephan, 2007, Stroschein-Stevenson et al., 2006, Stuart et al., 2007, Nybakken et al., 2005, Baeg et al., 2007, Barbash, 2007, Doheny et al., 2008, Capelson et al., 2010, Kalverda et al., 2010, Kalverda and Fornerod, 2010, Tian et al., 2011, Loop et al., 2004, Habermann et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Ranz et al., 2012) Nup-98 (Kallappagoudar et al., 2010) Nup 98 (Clark and Aquadro, 2010) Nup98-96   nup98-96 (Parrott et al., 2011) Nup98/96 (Sarkar et al., 2006) Nup98-Nup96 (Presgraves et al., 2003) nup145 (Chen and Xu, 2010)
Name Synonym	Nucleoporin 98 (Ranz et al., 2012) nucleoporin98-96 (Parrott et al., 2011) Nucleoporin 98-96   Nucleoporin 98-96kD   Nup98
Secondary FlyBase IDs
	FBgn0021781 FBgn0039119
References ( 54 )
Generate a list of	All references relating to this gene ( 54 )
List References by type	Research paper  ( 26 ) Supplementary material  ( 4 ) Review  ( 6 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 1 ) FlyBase analysis  ( 4 ) Note  ( 1 ) Stock list  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 5 )
	Habermann et al., 2012, Mol. Cell. Biol. 32(17): 3554--3569 Functional Analysis of Centrosomal Kinase Substrates in Drosophila melanogaster Reveals a New Function of the Nuclear Envelope Component Otefin in Cell Cycle Progression. [FBrf0219185] Ranz et al., 2012, Mol. Biol. Evol. 29(1): 13--16 Conserved gene order at the nuclear periphery in Drosophila. [FBrf0217437] Finan et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(14): 5566--5571 From the Cover: Proteomics approach to study the functions of Drosophila myosin VI through identification of multiple cargo-binding proteins. [FBrf0213355] Parrott et al., 2011, PLoS ONE 6(9): e25087 Nucleoporin98-96 Function Is Required for Transit Amplification Divisions in the Germ Line of Drosophila melanogaster. [FBrf0216255] Tian et al., 2011, Nat. Neurosci. 14(10): 1267--1275 Drosophila Rae1 controls the abundance of the ubiquitin ligase Highwire in post-mitotic neurons. [FBrf0216253] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...