FB2020_06, released Dec 22, 2020

Gene: Dmel\Root

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General Information
Symbol
Dmel\Root
Species
D. melanogaster
Name
Rootletin
Annotation Symbol
CG6129
Feature Type
protein_coding_gene
FlyBase ID
FBgn0039152
Gene Model Status
Current
Stock Availability
9 publicly available
Gene Snapshot
Rootletin (Root) encodes the major structural component of the ciliary rootlet. It is expressed in sensory neurons and is required for ciliary-transmitted sensory functions including hearing, touch and taste. [Date last reviewed: 2018-11-08]
Other Summaries
Key Links
Genomic Location
Cytogenetic map
95E1-95E1
Sequence location
3R:24,113,286..24,128,193 [+]
Recombination map

3-83

RefSeq locus
NT_033777 REGION:24113286..24128193
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (6 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (5 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
involved_in auditory behavior
inferred from mutant phenotype
(Styczynska-Soczka and Jarman, 2015)
involved_in ciliary basal body organization
inferred from mutant phenotype
(Styczynska-Soczka and Jarman, 2015)
involved_in mechanosensory behavior
inferred from mutant phenotype
(Styczynska-Soczka and Jarman, 2015)
involved_in sensory perception of sound
inferred from mutant phenotype
(Chen et al., 2015)
involved_in sensory perception of touch
inferred from mutant phenotype
(Chen et al., 2015)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
colocalizes_with ciliary rootlet
inferred from direct assay
(Laurençon et al., 2007)
located_in ciliary rootlet
inferred from direct assay
(Chen et al., 2015)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
    -
    Summaries
    Summary (Interactive Fly)

    structural component of base of cilia - organizes rootlets at the base of primary cilia in sensory neurons - essential for sensory neuron functions, including negative geotaxis, taste, touch response, and hearing - rootlet assembly requires centrioles

    Gene Model and Products
    Number of Transcripts
    3
    Number of Unique Polypeptides
    1

    Please see the JBrowse view of Dmel\Root for information on other features

    To submit a correction to a gene model please use the Contact FlyBase form

    Protein Domains (via Pfam)
    Isoform displayed:
    Pfam protein domains
    InterPro name
    classification
    start
    end
    Protein Domains (via SMART)
    Isoform displayed:
    SMART protein domains
    InterPro name
    classification
    start
    end
    Comments on Gene Model

    Low-frequency RNA-Seq exon junction(s) not annotated.

    Gene model reviewed during 5.49

    Sequence Ontology: Class of Gene
    nuclear_gene
    protein_coding_gene
    Transcript Data
    Annotated Transcripts
    Name
    FlyBase ID
    RefSeq ID
    Length (nt)
    Assoc. CDS (aa)
    Root-RD
    FBtr0304161
    NM_142959
    6731
    2048
    Root-RE
    FBtr0339244
    NM_001300568
    7040
    2048
    Root-RF
    FBtr0339245
    NM_176553
    7005
    2048
    Additional Transcript Data and Comments
    Reported size (kB)
    Comments
    External Data
    Crossreferences
    Polypeptide Data
    Annotated Polypeptides
    Name
    FlyBase ID
    Predicted MW (kDa)
    Length (aa)
    Theoretical pI
    RefSeq ID
    GenBank
    Root-PD
    FBpp0293091
    232.7
    2048
    6.13
    NP_651216
    AAF56238
    Root-PE
    FBpp0308351
    232.7
    2048
    6.13
    NP_001287497
    AHN57496
    Root-PF
    FBpp0308352
    232.7
    2048
    6.13
    NP_788730
    AAN13982
    Polypeptides with Identical Sequences

    The group(s) of polypeptides indicated below share identical sequence to each other.

    2048 aa isoforms: Root-PD, Root-PE, Root-PF
    Additional Polypeptide Data and Comments
    Reported size (kDa)
    Comments
    External Data
    Crossreferences
    Linkouts
    Sequences Consistent with the Gene Model
    Mapped Features

    Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Root using the Feature Mapper tool.

    External Data
    Crossreferences
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Linkouts
    Expression Data
    Expression Summary Ribbons
    Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
    For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
    Transcript Expression
    in situ
    Stage
    Tissue/Position (including subcellular localization)
    Reference
    embryonic stage 11
    chordotonal organ precursor cell
    (Cachero et al., 2011)
    embryonic stage 12 -- 15
    scolopidial neuron
    (Styczynska-Soczka and Jarman, 2015)
    embryonic stage 12
    sensory neuron
    (Styczynska-Soczka and Jarman, 2015)
    olfactory sensory organ
    (Styczynska-Soczka and Jarman, 2015)
    gustatory sensory organ
    (Styczynska-Soczka and Jarman, 2015)
    external sensory organ
    (Styczynska-Soczka and Jarman, 2015)
    mechanosensory sensory organ
    (Styczynska-Soczka and Jarman, 2015)
    auditory sensory neuron
    (Styczynska-Soczka and Jarman, 2015)
    Additional Descriptive Data

    Root is expressed in a dynamic pattern corresponding to developing sensory neuron lineages. Starting in stage 12 it is expressed in all precursor and progeny cells of type I sensory lineages of all sensory modalities (including olfactory, external sensory (mechanosensory and gustatory), and chordotonal (auditory and proprioceptive) neurons. Expression continues in these lineages but appears to become restricted to chordotonal neurons. Expression appears to occur exclusively and transiently in the lineages leading to cells that differentiate a cilium.

    (Styczynska-Soczka and Jarman, 2015)
    Marker for
     
    Subcellular Localization
    CV Term
    Polypeptide Expression
    immunolocalization
    Stage
    Tissue/Position (including subcellular localization)
    Reference
    adult stage
    Johnston organ neuron
    (Chen et al., 2015)
    femoral chordotonal organ
    (Chen et al., 2015)
    eo neuron
    (Chen et al., 2015)
    antennal olfactory receptor neuron
    (Chen et al., 2015)
    late embryonic stage
    desD neuron
    (Chen et al., 2015)
    desC neuron
    (Chen et al., 2015)
    desB neuron
    (Chen et al., 2015)
    des2 neuron
    (Chen et al., 2015)
    lesC neuron
    (Chen et al., 2015)
    lesB neuron
    (Chen et al., 2015)
    lesA neuron
    (Chen et al., 2015)
    lch1 neuron
    (Chen et al., 2015)
    abdominal lch5 neuron
    (Chen et al., 2015)
    v'es2 neuron
    (Chen et al., 2015)
    v''esB neuron
    (Chen et al., 2015)
    v''esA neuron
    (Chen et al., 2015)
    abdominal vch2 neuron
    (Chen et al., 2015)
    abdominal vch1 neuron
    (Chen et al., 2015)
    vesC neuron
    (Chen et al., 2015)
    vesB neuron
    (Chen et al., 2015)
    vesA neuron
    (Chen et al., 2015)
    scolopidial neuron
    (Chen et al., 2015)
    eo neuron
    (Chen et al., 2015)
    mass spectroscopy
    Stage
    Tissue/Position (including subcellular localization)
    Reference
    day 5 of adulthood & male -- day 7 of adulthood & male
    spermatozoon
    (Wasbrough et al., 2010)
    western blot
    Stage
    Tissue/Position (including subcellular localization)
    Reference
    adult stage
    antenna
    (Chen et al., 2015)
    Additional Descriptive Data

    Root-protein is detected in the ciliary rootlet of scolopidial neurons as well as in neurons of external sensory organs.

    (Chen et al., 2015)
    Marker for
     
    Subcellular Localization
    CV Term
    Evidence
    References
    colocalizes_with ciliary rootlet
    inferred from direct assay
    (Laurençon et al., 2007)
    located_in ciliary rootlet
    inferred from direct assay
    (Chen et al., 2015)
    Expression Deduced from Reporters
    High-Throughput Expression Data
    Associated Tools

    GBrowse - Visual display of RNA-Seq signals

    View Dmel\Root in GBrowse 2
    RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
    Bulk Downloads
    RNA-Seq RPKM values for all genes
    Reference
    See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
    Developmental Proteome: Life Cycle
    Developmental Proteome: Embryogenesis
    External Data and Images
    Linkouts
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    Images
    FlyBase Wiki
    Image Based Resources
    Alleles, Insertions, and Transgenic Constructs
    Classical and Insertion Alleles ( 16 )
    For All Classical and Insertion Alleles Show
     
    Other relevant insertions
    Transgenic Constructs ( 10 )
    For All Alleles Carried on Transgenic Constructs Show
    Transgenic constructs containing/affecting coding region of Root
    Transgenic constructs containing regulatory region of Root
    Deletions and Duplications ( 1 )
    Phenotypes
    For more details about a specific phenotype click on the relevant allele symbol.
    Lethality
    Allele
    viable
    viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
    viable, with Scer\GAL4Mef2.PR
    viable, with Scer\GAL4pnr-MD237
    viable, with Scer\GAL4sca.PU
    viable, with Scer\GAL4tin.CΔ4
    Sterility
    Allele
    male semi-sterile (with Df(3R)Exel6197)
    male sterile
    Other Phenotypes
    Allele
    auditory perception defective (with Df(3R)Exel6197)
    auditory perception defective | larval stage, with Scer\GAL4sca.PU
    auditory perception defective | recessive
    grooming behavior defective | adult stage, with Scer\GAL4sca.PU
    locomotor behavior defective | adult stage
    locomotor behavior defective | adult stage, with Scer\GAL4elav-C155
    locomotor behavior defective | adult stage (with Df(3R)Exel6197)
    locomotor behavior defective | adult stage | progressive, with Scer\GAL4sca.PU
    locomotor behavior defective | larval stage, with Scer\GAL4sca.PU
    neuroanatomy defective | adult stage (with Df(3R)Exel6197)
    neurophysiology defective | adult stage (with Df(3R)Exel6197)
    neurophysiology defective | adult stage | recessive
    proboscis extension reflex defective | recessive
    touch response defective | larval stage
    touch response defective | larval stage (with Df(3R)Exel6197)
    uncoordinated | adult stage | recessive
    Phenotype manifest in
    Allele
    centriole, with Scer\GAL4sca.PU
    ciliary basal body, with Scer\GAL4sca.PU
    ciliary rootlet, with Scer\GAL4sca.PU
    ciliary rootlet (with Df(3R)Exel6197)
    Johnston organ (with Df(3R)Exel6197)
    Orthologs
    Downloads
    Download All DIOPT Orthologs
    Download All OrthoDB Orthologs
    Human Orthologs (via DIOPT v8.0)
    Homo sapiens (Human) (8)
    Species\Gene Symbol
    Score
    Best Score
    Best Reverse Score
    Source
    Compara
    eggNOG
    Hieranoid
    Homologene
    Inparanoid
    Isobase
    OMA
    OrthoDB
    OrthoFinder
    OrthoInspector
    orthoMCL
    Panther
    Phylome
    RoundUp
    TreeFam
    ZFIN
    Alignment
    Complementation?
    Transgene?
    Hsap\CROCC
    12 of 15
    Yes
    Yes
    Hsap\CEP250
    7 of 15
    No
    Yes
    Hsap\CROCC2
    4 of 15
    No
    Yes
    Hsap\CROCCP2
    1 of 15
    No
    Yes
    Hsap\CROCCP3
    1 of 15
    No
    Yes
    Hsap\JMY
    1 of 15
    No
    Yes
    Hsap\MYH16
    1 of 15
    No
    Yes
    Hsap\WHAMM
    1 of 15
    No
    Yes
    Model Organism Orthologs (via DIOPT v8.0)
    Mus musculus (laboratory mouse) (5)
    Species\Gene Symbol
    Score
    Best Score
    Best Reverse Score
    Source
    Compara
    eggNOG
    Hieranoid
    Homologene
    Inparanoid
    Isobase
    OMA
    OrthoDB
    OrthoFinder
    OrthoInspector
    orthoMCL
    Panther
    Phylome
    RoundUp
    TreeFam
    ZFIN
    Alignment
    Complementation?
    Transgene?
    Mmus\Crocc
    12 of 15
    Yes
    Yes
    Mmus\Cep250
    7 of 15
    No
    Yes
    Mmus\Crocc2
    3 of 15
    No
    Yes
    Mmus\Jmy
    1 of 15
    No
    Yes
    Mmus\Whamm
    1 of 15
    No
    Yes
    Rattus norvegicus (Norway rat) (3)
    Rnor\Crocc
    11 of 13
    Yes
    Yes
    Rnor\Cep250
    4 of 13
    No
    Yes
    Rnor\Crocc2
    2 of 13
    No
    Yes
    Xenopus tropicalis (Western clawed frog) (6)
    Xtro\crocc
    6 of 12
    Yes
    Yes
    Xtro\crocc2
    3 of 12
    No
    Yes
    Xtro\LOC100487173
    2 of 12
    No
    Yes
    Xtro\LOC100498015
    2 of 12
    No
    Yes
    Xtro\jmy
    1 of 12
    No
    Yes
    Xtro\whamm
    1 of 12
    No
    Yes
    Danio rerio (Zebrafish) (5)
    Drer\crocc2
    12 of 15
    Yes
    Yes
    Drer\si:dkey-230p4.1
    3 of 15
    No
    Yes
    Drer\cep128
    1 of 15
    No
    Yes
    Drer\jmy
    1 of 15
    No
    Yes
    Drer\si:ch73-242m19.1
    1 of 15
    No
    Yes
    Caenorhabditis elegans (Nematode, roundworm) (2)
    Cele\lfi-1
    9 of 15
    Yes
    Yes
    Cele\che-10
    3 of 15
    No
    Yes
    Arabidopsis thaliana (thale-cress) (0)
    No records found.
    Saccharomyces cerevisiae (Brewer's yeast) (0)
    No records found.
    Schizosaccharomyces pombe (Fission yeast) (1)
    Spom\spo15
    1 of 12
    Yes
    No
    Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091900EP )
    Organism
    Common Name
    Gene
    AAA Syntenic Ortholog
    Multiple Dmel Genes in this Orthologous Group
    Drosophila suzukii
    Spotted wing Drosophila
    Dsuz\DS10_00008954
    Drosophila suzukii
    Spotted wing Drosophila
    Dsuz\DS10_00008955
    Drosophila simulans
    Dsim\GD21065
    Drosophila sechellia
    Dsec\GM26559
    Drosophila erecta
    Dere\GG11254
    Drosophila yakuba
    Dyak\GE23447
    Drosophila ananassae
    Dana\GF16104
    Drosophila pseudoobscura pseudoobscura
    Dpse\GA19376
    Drosophila persimilis
    Dper\GL23404
    Drosophila willistoni
    Dwil\GK11156
    Drosophila virilis
    Dvir\GJ14200
    Drosophila mojavensis
    Dmoj\GI24167
    Drosophila grimshawi
    Dgri\GH18493
    Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150094 )
    Organism
    Common Name
    Gene
    Multiple Dmel Genes in this Orthologous Group
    Musca domestica
    House fly
    Mdoa\17010052
    Glossina morsitans
    Tsetse fly
    Gmor\GMOY009506
    Lucilia cuprina
    Australian sheep blowfly
    Lcup\FF38_14017
    Mayetiola destructor
    Hessian fly
    Mdes\Mdes009401
    Aedes aegypti
    Yellow fever mosquito
    Aaeg\AAEL009915
    Anopheles darlingi
    American malaria mosquito
    Adar\ADAC000783
    Anopheles darlingi
    American malaria mosquito
    Adar\ADAC000784
    Anopheles gambiae
    Malaria mosquito
    Agam\AGAP003449
    Culex quinquefasciatus
    Southern house mosquito
    Cqui\CPIJ001714
    Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01W7 )
    Organism
    Common Name
    Gene
    Multiple Dmel Genes in this Orthologous Group
    Bombyx mori
    Silkmoth
    Bmor\BGIBMGA006338
    Danaus plexippus
    Monarch butterfly
    Dple\DPOGS210726-PA
    Heliconius melpomene
    Postman butterfly
    Hmel\HMEL006430
    Apis florea
    Little honeybee
    Aflo\3440415508
    Apis mellifera
    Western honey bee
    Amel\GB51348
    Bombus impatiens
    Common eastern bumble bee
    Bimp\BIMP20074
    Bombus terrestris
    Buff-tailed bumblebee
    Bter\15208521
    Linepithema humile
    Argentine ant
    Lhum\LH10797
    Megachile rotundata
    Alfalfa leafcutting bee
    Mrot\MROTU:001d48
    Nasonia vitripennis
    Parasitic wasp
    Nvit\Nasvi2EG011394
    Dendroctonus ponderosae
    Mountain pine beetle
    Dpod\YQE_00578
    Dendroctonus ponderosae
    Mountain pine beetle
    Dpod\YQE_02829
    Dendroctonus ponderosae
    Mountain pine beetle
    Dpod\YQE_03011
    Dendroctonus ponderosae
    Mountain pine beetle
    Dpod\YQE_00232
    Tribolium castaneum
    Red flour beetle
    Tcas\TC000358
    Tribolium castaneum
    Red flour beetle
    Tcas\TC005246
    Pediculus humanus
    Human body louse
    Phum\PHUM376800
    Rhodnius prolixus
    Kissing bug
    Rpro\RPRC004937
    Rhodnius prolixus
    Kissing bug
    Rpro\RPRC013881
    Cimex lectularius
    Bed bug
    Clec\CLEC012063
    Acyrthosiphon pisum
    Pea aphid
    Apim\ACYPI007000
    Zootermopsis nevadensis
    Nevada dampwood termite
    Znev\Znev_12623
    Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X01TU )
    Organism
    Common Name
    Gene
    Multiple Dmel Genes in this Orthologous Group
    Strigamia maritima
    European centipede
    Smar\SMAR002973
    Ixodes scapularis
    Black-legged tick
    Isca\ISCW017899
    Stegodyphus mimosarum
    African social velvet spider
    Smim\KFM71171.1
    Stegodyphus mimosarum
    African social velvet spider
    Smim\KFM71173.1
    Daphnia pulex
    Water flea
    Dpux\DAPPUDRAFT_241761
    Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G034H )
    Organism
    Common Name
    Gene
    Multiple Dmel Genes in this Orthologous Group
    Strongylocentrotus purpuratus
    Purple sea urchin
    Spur\Sp-Crocc-3
    Strongylocentrotus purpuratus
    Purple sea urchin
    Spur\Sp-Crocc_4
    Strongylocentrotus purpuratus
    Purple sea urchin
    Spur\Sp-Crocc2
    Strongylocentrotus purpuratus
    Purple sea urchin
    Spur\SPU_004200gn
    Strongylocentrotus purpuratus
    Purple sea urchin
    Spur\Sp-Crocc
    Ciona intestinalis
    Vase tunicate
    Cint\ENSCING00000019690
    Ciona intestinalis
    Vase tunicate
    Cint\ENSCING00000025023
    Ciona intestinalis
    Vase tunicate
    Cint\ENSCING00000022767
    Ciona intestinalis
    Vase tunicate
    Cint\ENSCING00000024864
    Gallus gallus
    Domestic chicken
    Ggal\ENSGALG00000026151
    Gallus gallus
    Domestic chicken
    Ggal\CEP250
    Gallus gallus
    Domestic chicken
    Ggal\ENSGALG00000027085
    Paralogs
    Downloads
    Download All DIOPT Paralogs
    Paralogs (via DIOPT v8.0)
    Drosophila melanogaster (Fruit fly) (1)
    Gene Symbol
    Score
    Source
    Compara
    eggNOG
    Homologene
    Inparanoid
    Isobase
    OrthoDB
    OrthoFinder
    orthoMCL
    Panther
    RoundUp
    Alignment
    Cep135
    1 of 10
    Human Disease Associations
    FlyBase Human Disease Model Reports
      Disease Model Summary Ribbon
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Allele
      Disease
      Evidence
      References
      Potential Models Based on Orthology ( 0 )
      Human Ortholog
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Allele
      Disease
      Interaction
      References
      Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
      Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
      Homo sapiens (Human)
      Gene name
      Score
      OMIM
      OMIM Phenotype
      DO term
      Complementation?
      Transgene?
      CROCC; ciliary rootlet coiled-coil, rootletin
      12 of 15
      615776
          CEP250; centrosomal protein 250
          7 of 15
          609689
            CROCC2; ciliary rootlet coiled-coil, rootletin family member 2
            4 of 15
                Functional Complementation Data
                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                Interactions
                Summary of Physical Interactions
                esyN Network Diagram
                Show neighbor-neighbor interactions:
                Select Layout:
                Legend:
                Protein
                RNA
                Selected Interactor(s)
                Interactions Browser
                View in Interactions Browser
                Please see the Physical Interaction reports below for full details
                RNA-protein
                Physical Interaction
                Assay
                References
                Root - orb2
                pull down, western blot
                (Mastushita-Sakai et al., 2010)
                Summary of Genetic Interactions
                esyN Network Diagram
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                External Data
                Linkouts
                DroID - A comprehensive database of gene and protein interactions.
                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Pathways
                Signaling Pathways (FlyBase)
                Metabolic Pathways
                External Data
                Linkouts
                Genomic Location and Detailed Mapping Data
                Chromosome (arm)
                3R
                Recombination map

                3-83

                Cytogenetic map
                95E1-95E1
                Sequence location
                3R:24,113,286..24,128,193 [+]
                FlyBase Computed Cytological Location
                Cytogenetic map
                Evidence for location
                95E1-95E1
                Limits computationally determined from genome sequence between P{PZ}Syx1A06737&P{PZ}Syx1A10660 and P{PZ}crb07207&P{PZ}BRWD305842
                Experimentally Determined Cytological Location
                Cytogenetic map
                Notes
                References
                Experimentally Determined Recombination Data
                Location

                3-83

                (FlyBase, 2016)

                3-82.7

                (Comeron et al., 2012)
                Left of (cM)
                Right of (cM)
                Notes
                Stocks and Reagents
                Stocks (9)
                Genomic Clones (18)
                 

                Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                cDNA Clones (20)
                 

                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                cDNA clones, fully sequenced
                BDGP DGC clones
                Other clones
                  Drosophila Genomics Resource Center cDNA clones

                  For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                  cDNA Clones, End Sequenced (ESTs)
                  BDGP DGC clones
                  Other clones
                  RNAi and Array Information
                  Linkouts
                  DRSC - Results frm RNAi screens
                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                  Antibody Information
                  Laboratory Generated Antibodies
                   

                  polyclonal

                  (Chen et al., 2015)
                  Commercially Available Antibodies
                   
                  Other Information
                  Relationship to Other Genes
                  Source for database identify of

                  Source for identity of: Rootletin CG6129

                  (Laurençon et al., 2007)

                  Source for identity of: Root Rootletin

                  (Chen et al., 2015)
                  Source for database merge of
                  Additional comments
                  Other Comments

                  Root is essential for ciliary rootlet formation and for cohesion of basal bodies, but the structure of the cilium appears normal in mutant neurons. Root is required for normal neuron sensory perception.

                  (Chen et al., 2015)
                  Origin and Etymology
                  Discoverer
                  Etymology

                  The name "Rootletin" is based on sequence homology.

                  (Laurençon et al., 2007)
                  Identification
                  External Crossreferences and Linkouts ( 33 )
                  Sequence Crossreferences
                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                  UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                  Other crossreferences
                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                  Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                  Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                  Flygut - An atlas of the Drosophila adult midgut
                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                  KEGG Genes - Molecular building blocks of life in the genomic space.
                  modMine - A data warehouse for the modENCODE project
                  Linkouts
                  DroID - A comprehensive database of gene and protein interactions.
                  DRSC - Results frm RNAi screens
                  FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                  FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                  FlyMine - An integrated database for Drosophila genomics
                  Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                  InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                  MIST (protein-protein) - An integrated Molecular Interaction Database
                  Synonyms and Secondary IDs (5)
                  Datasets (0)
                  Study focus (0)
                  Experimental Role
                  Project
                  Project Type
                  Title
                  References (41)