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Gene Dmel\CG5524

General Information
Symbol	Dmel\CG5524	Species	D. melanogaster
Name		Annotation symbol	CG5524
Feature type	protein_coding_gene	FlyBase ID	FBgn0039164
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	95E8-95F1	Sequence location	3R:20,014,770..20,019,145 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG5524 (FBgn0039164). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. Based on sequence similarity, it is predicted to be involved in the biological process: DNA repair. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: RecF/RecN/SMC. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1639138_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG5524. Gene sequence location is 3R:20014770..20019145.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10	Controlled Vocabulary Terms day 6 of adulthood day 5 of adulthood male day 7 of adulthood spermatozoon
FB2012_01	References Chiolo et al., 2011, Cell 144(5): 732--744 Sequence features BKN22340 HFA15829
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 95E8-95F1   Limits computationally determined from genome sequence between P{PZ}Syx1A06737&P{PZ}Syx1A10660 and P{PZ}crb07207&P{PZ}BRWD305842
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG5524 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG5524-RA FBtr0084573  NM_142971   3592   1122
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG5524-PA   FBpp0083958   129.3   1122   8.52     NP_651228   AAF56254
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • RecF/RecN/SMC (IPR003395)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF56254   BE978036   BF492738   BF492739   BI641892   BP554972   BT023747   CO177445   CO177446   CO179545   CO179546   CO188813   CO190801   CO190802   CO270272   CO297046   CO341825   EC069299   EC069300   EC069301   EC196924   EC219720   EC251484
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VCB8
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0039164    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0039164 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0039164 expression level Developmental Stage   Expression Level embryo 00-02hr    1742 embryo 02-04hr    480 embryo 04-06hr    1744 embryo 06-08hr    1157 embryo 08-10hr    637 embryo 10-12hr    240 embryo 12-14hr    219 embryo 14-16hr    118 embryo 16-18hr    140 embryo 18-20hr    125 embryo 20-22hr    151 embryo 22-24hr    198 larva L1    245 larva L2    223 larva L3 12hr old    167 larva L3 puffstage 1-2    289 larva L3 puffstage 3-6    539 larva L3 puffstage 7-9    766 white prepupae new    667 white prepupae 12hr    1025 white prepupae 24hr    1259 pupae 2d postWPP    1282 pupae 3d postWPP    1112 pupae 4d postWPP    566 adult male 01day    1237 adult male 05day    1641 adult male 30day    1291 adult female 01day    505 adult female 05day    1460 adult female 30day    1381 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1742) embryo 02-04hr  (480) embryo 04-06hr  (1744) embryo 06-08hr  (1157) embryo 08-10hr  (637) embryo 10-12hr  (240) embryo 12-14hr  (219) embryo 14-16hr  (118) embryo 16-18hr  (140) embryo 18-20hr  (125) embryo 20-22hr  (151) embryo 22-24hr  (198) larva L1  (245) larva L2  (223) larva L3 12hr old  (167) larva L3 puffstage 1-2  (289) larva L3 puffstage 3-6  (539) larva L3 puffstage 7-9  (766) white prepupae new  (667) white prepupae 12hr  (1025) white prepupae 24hr  (1259) pupae 2d postWPP  (1282) pupae 3d postWPP  (1112) pupae 4d postWPP  (566) adult male 01day  (1237) adult male 05day  (1641) adult male 30day  (1291) adult female 01day  (505) adult female 05day  (1460) adult female 30day  (1381) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (1742) embryo 02-04hr    480 embryo 04-06hr  (1744) embryo 06-08hr    1157 embryo 08-10hr    637 embryo 10-12hr    240 embryo 12-14hr    219 embryo 14-16hr    118 embryo 16-18hr    140 embryo 18-20hr    125 embryo 20-22hr    151 embryo 22-24hr    198 larva L1    245 larva L2    223 larva L3 12hr old    167 larva L3 puffstage 1-2    289 larva L3 puffstage 3-6    539 larva L3 puffstage 7-9    766 white prepupae new    667 white prepupae 12hr    1025 white prepupae 24hr    1259 pupae 2d postWPP    1282 pupae 3d postWPP    1112 pupae 4d postWPP    566 adult male 01day    1237 adult male 05day  (1641) adult male 30day    1291 adult female 01day    505 adult female 05day  1460 adult female 30day    1381 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1742 embryo 02-04hr    480 embryo 04-06hr    1744 embryo 06-08hr    1157 embryo 08-10hr    637 embryo 10-12hr    240 embryo 12-14hr    219 embryo 14-16hr    118 embryo 16-18hr    140 embryo 18-20hr    125 embryo 20-22hr    151 embryo 22-24hr    198 larva L1    245 larva L2    223 larva L3 12hr old    167 larva L3 puffstage 1-2    289 larva L3 puffstage 3-6    539 larva L3 puffstage 7-9    766 white prepupae new    667 white prepupae 12hr    1025 white prepupae 24hr    1259 pupae 2d postWPP    1282 pupae 3d postWPP    1112 pupae 4d postWPP    566 adult male 01day    1237 adult male 05day    1641 adult male 30day    1291 adult female 01day    505 adult female 05day    1460 adult female 30day    1381 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1742 embryo 02-04hr    480 embryo 04-06hr    1744 embryo 06-08hr    1157 embryo 08-10hr    637 embryo 10-12hr    240 embryo 12-14hr    219 embryo 14-16hr    118 embryo 16-18hr    140 embryo 18-20hr    125 embryo 20-22hr    151 embryo 22-24hr    198 larva L1    245 larva L2    223 larva L3 12hr old    167 larva L3 puffstage 1-2    289 larva L3 puffstage 3-6    539 larva L3 puffstage 7-9    766 white prepupae new    667 white prepupae 12hr    1025 white prepupae 24hr    1259 pupae 2d postWPP    1282 pupae 3d postWPP    1112 pupae 4d postWPP    566 adult male 01day    1237 adult male 05day    1641 adult male 30day    1291 adult female 01day    505 adult female 05day    1460 adult female 30day    1381 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0039164 expression level Developmental Stage   Expression Level embryo 00-02hr    1742 embryo 02-04hr    480 embryo 04-06hr    1744 embryo 06-08hr    1157 embryo 08-10hr    637 embryo 10-12hr    240 embryo 12-14hr    219 embryo 14-16hr    118 embryo 16-18hr    140 embryo 18-20hr    125 embryo 20-22hr    151 embryo 22-24hr    198 larva L1    245 larva L2    223 larva L3 12hr old    167 larva L3 puffstage 1-2    289 larva L3 puffstage 3-6    539 larva L3 puffstage 7-9    766 white prepupae new    667 white prepupae 12hr    1025 white prepupae 24hr    1259 pupae 2d postWPP    1282 pupae 3d postWPP    1112 pupae 4d postWPP    566 adult male 01day    1237 adult male 05day    1641 adult male 30day    1291 adult female 01day    505 adult female 05day    1460 adult female 30day    1381 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1742) embryo 02-04hr  (480) embryo 04-06hr  (1744) embryo 06-08hr  (1157) embryo 08-10hr  (637) embryo 10-12hr  (240) embryo 12-14hr  (219) embryo 14-16hr  118 embryo 16-18hr  140 embryo 18-20hr  125 embryo 20-22hr  (151) embryo 22-24hr  (198) larva L1  (245) larva L2  (223) larva L3 12hr old  (167) larva L3 puffstage 1-2  (289) larva L3 puffstage 3-6  (539) larva L3 puffstage 7-9  (766) white prepupae new  (667) white prepupae 12hr  (1025) white prepupae 24hr  (1259) pupae 2d postWPP  (1282) pupae 3d postWPP  (1112) pupae 4d postWPP  (566) adult male 01day  (1237) adult male 05day  (1641) adult male 30day  (1291) adult female 01day  (505) adult female 05day  (1460) adult female 30day  (1381) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  1742 embryo 02-04hr    480 embryo 04-06hr  1744 embryo 06-08hr    1157 embryo 08-10hr    637 embryo 10-12hr    240 embryo 12-14hr    219 embryo 14-16hr    118 embryo 16-18hr    140 embryo 18-20hr    125 embryo 20-22hr    151 embryo 22-24hr    198 larva L1    245 larva L2    223 larva L3 12hr old    167 larva L3 puffstage 1-2    289 larva L3 puffstage 3-6    539 larva L3 puffstage 7-9    766 white prepupae new    667 white prepupae 12hr    1025 white prepupae 24hr    1259 pupae 2d postWPP    1282 pupae 3d postWPP    1112 pupae 4d postWPP    566 adult male 01day    1237 adult male 05day  1641 adult male 30day    1291 adult female 01day    505 adult female 05day  1460 adult female 30day    1381 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1742 embryo 02-04hr    480 embryo 04-06hr    1744 embryo 06-08hr    1157 embryo 08-10hr    637 embryo 10-12hr    240 embryo 12-14hr    219 embryo 14-16hr    118 embryo 16-18hr    140 embryo 18-20hr    125 embryo 20-22hr    151 embryo 22-24hr    198 larva L1    245 larva L2    223 larva L3 12hr old    167 larva L3 puffstage 1-2    289 larva L3 puffstage 3-6    539 larva L3 puffstage 7-9    766 white prepupae new    667 white prepupae 12hr    1025 white prepupae 24hr    1259 pupae 2d postWPP    1282 pupae 3d postWPP    1112 pupae 4d postWPP    566 adult male 01day    1237 adult male 05day    1641 adult male 30day    1291 adult female 01day    505 adult female 05day    1460 adult female 30day    1381 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1742 embryo 02-04hr    480 embryo 04-06hr    1744 embryo 06-08hr    1157 embryo 08-10hr    637 embryo 10-12hr    240 embryo 12-14hr    219 embryo 14-16hr    118 embryo 16-18hr    140 embryo 18-20hr    125 embryo 20-22hr    151 embryo 22-24hr    198 larva L1    245 larva L2    223 larva L3 12hr old    167 larva L3 puffstage 1-2    289 larva L3 puffstage 3-6    539 larva L3 puffstage 7-9    766 white prepupae new    667 white prepupae 12hr    1025 white prepupae 24hr    1259 pupae 2d postWPP    1282 pupae 3d postWPP    1112 pupae 4d postWPP    566 adult male 01day    1237 adult male 05day    1641 adult male 30day    1291 adult female 01day    505 adult female 05day    1460 adult female 30day    1381 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0039164    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0039164 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0039164 expression level Tissue   Expression Level Larval Central Nervous System    132.325 Larval Midgut    17.2 Larval Hindgut    24.9 Larval Malpighian Tubules    28.9 Larval Fat Body    67.1 Larval Salivary Gland    22.3 Larval Trachea    38.9 Larval Carcass    25.625 Adult Head    33.2 Adult Eye    24.7 Adult Brain    97.5 Adult Thoracic-Abdominal Ganglion    67.1 Adult Crop    37.5 Adult Midgut    20.3 Adult Hindgut    26.1 Adult Malpighian Tubules    36.1 Adult Fat Body    16.5 Adult Salivary Gland no informative data Adult Heart    21.15 Adult VirginFemale Spermatheca    24.7 Adult InseminatedFemale Spermatheca    26.5 Adult Ovary    280.6 Adult Testis    325.5 Adult Male Accessory Gland    27.2 Adult Carcass    26.9 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    132.325 Larval Midgut    17.2 Larval Hindgut    24.9 Larval Malpighian Tubules    28.9 Larval Fat Body    67.1 Larval Salivary Gland    22.3 Larval Trachea    38.9 Larval Carcass    25.625 Adult Head    33.2 Adult Eye    24.7 Adult Brain    97.5 Adult Thoracic-Abdominal Ganglion    67.1 Adult Crop    37.5 Adult Midgut    20.3 Adult Hindgut    26.1 Adult Malpighian Tubules    36.1 Adult Fat Body    16.5 Adult Salivary Gland no informative data Adult Heart    21.15 Adult VirginFemale Spermatheca    24.7 Adult InseminatedFemale Spermatheca    26.5 Adult Ovary    280.6 Adult Testis    325.5 Adult Male Accessory Gland    27.2 Adult Carcass    26.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    132.325 Larval Midgut    17.2 Larval Hindgut    24.9 Larval Malpighian Tubules    28.9 Larval Fat Body    67.1 Larval Salivary Gland    22.3 Larval Trachea    38.9 Larval Carcass    25.625 Adult Head    33.2 Adult Eye    24.7 Adult Brain    97.5 Adult Thoracic-Abdominal Ganglion    67.1 Adult Crop    37.5 Adult Midgut    20.3 Adult Hindgut    26.1 Adult Malpighian Tubules    36.1 Adult Fat Body    16.5 Adult Salivary Gland no informative data Adult Heart    21.15 Adult VirginFemale Spermatheca    24.7 Adult InseminatedFemale Spermatheca    26.5 Adult Ovary    280.6 Adult Testis    325.5 Adult Male Accessory Gland    27.2 Adult Carcass    26.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    132.325 Larval Midgut    17.2 Larval Hindgut    24.9 Larval Malpighian Tubules    28.9 Larval Fat Body    67.1 Larval Salivary Gland    22.3 Larval Trachea    38.9 Larval Carcass    25.625 Adult Head    33.2 Adult Eye    24.7 Adult Brain    97.5 Adult Thoracic-Abdominal Ganglion    67.1 Adult Crop    37.5 Adult Midgut    20.3 Adult Hindgut    26.1 Adult Malpighian Tubules    36.1 Adult Fat Body    16.5 Adult Salivary Gland no informative data Adult Heart    21.15 Adult VirginFemale Spermatheca    24.7 Adult InseminatedFemale Spermatheca    26.5 Adult Ovary    280.6 Adult Testis    325.5 Adult Male Accessory Gland    27.2 Adult Carcass    26.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0039164 expression level Tissue   Expression Level Larval Central Nervous System    132.325 Larval Midgut    17.2 Larval Hindgut    24.9 Larval Malpighian Tubules    28.9 Larval Fat Body    67.1 Larval Salivary Gland    22.3 Larval Trachea    38.9 Larval Carcass    25.625 Adult Head    33.2 Adult Eye    24.7 Adult Brain    97.5 Adult Thoracic-Abdominal Ganglion    67.1 Adult Crop    37.5 Adult Midgut    20.3 Adult Hindgut    26.1 Adult Malpighian Tubules    36.1 Adult Fat Body    16.5 Adult Salivary Gland no informative data Adult Heart    21.15 Adult VirginFemale Spermatheca    24.7 Adult InseminatedFemale Spermatheca    26.5 Adult Ovary    280.6 Adult Testis    325.5 Adult Male Accessory Gland    27.2 Adult Carcass    26.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    132.325 Larval Midgut    17.2 Larval Hindgut    24.9 Larval Malpighian Tubules    28.9 Larval Fat Body    67.1 Larval Salivary Gland    22.3 Larval Trachea    38.9 Larval Carcass    25.625 Adult Head    33.2 Adult Eye    24.7 Adult Brain    97.5 Adult Thoracic-Abdominal Ganglion    67.1 Adult Crop    37.5 Adult Midgut    20.3 Adult Hindgut    26.1 Adult Malpighian Tubules    36.1 Adult Fat Body    16.5 Adult Salivary Gland no informative data Adult Heart    21.15 Adult VirginFemale Spermatheca    24.7 Adult InseminatedFemale Spermatheca    26.5 Adult Ovary    280.6 Adult Testis    325.5 Adult Male Accessory Gland    27.2 Adult Carcass    26.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    132.325 Larval Midgut    17.2 Larval Hindgut    24.9 Larval Malpighian Tubules    28.9 Larval Fat Body    67.1 Larval Salivary Gland    22.3 Larval Trachea    38.9 Larval Carcass    25.625 Adult Head    33.2 Adult Eye    24.7 Adult Brain    97.5 Adult Thoracic-Abdominal Ganglion    67.1 Adult Crop    37.5 Adult Midgut    20.3 Adult Hindgut    26.1 Adult Malpighian Tubules    36.1 Adult Fat Body    16.5 Adult Salivary Gland no informative data Adult Heart    21.15 Adult VirginFemale Spermatheca    24.7 Adult InseminatedFemale Spermatheca    26.5 Adult Ovary    280.6 Adult Testis    325.5 Adult Male Accessory Gland    27.2 Adult Carcass    26.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    132.325 Larval Midgut    17.2 Larval Hindgut    24.9 Larval Malpighian Tubules    28.9 Larval Fat Body    67.1 Larval Salivary Gland    22.3 Larval Trachea    38.9 Larval Carcass    25.625 Adult Head    33.2 Adult Eye    24.7 Adult Brain    97.5 Adult Thoracic-Abdominal Ganglion    67.1 Adult Crop    37.5 Adult Midgut    20.3 Adult Hindgut    26.1 Adult Malpighian Tubules    36.1 Adult Fat Body    16.5 Adult Salivary Gland no informative data Adult Heart    21.15 Adult VirginFemale Spermatheca    24.7 Adult InseminatedFemale Spermatheca    26.5 Adult Ovary    280.6 Adult Testis    325.5 Adult Male Accessory Gland    27.2 Adult Carcass    26.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    33.2   NA  Eye    24.7   NA  Brain    97.5   132.325  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    67.1   NA  Crop    37.5   17.2  Midgut    20.3   24.9  Hindgut    26.1   28.9  Malpighian Tubules    36.1   67.1  Fat Body    16.5   22.3  Salivary Gland    no informative data   NA  Heart    21.15   38.9  Trachea    NA   NA  VirginFemale Spermatheca    24.7   NA  InseminatedFemale Spermatheca    26.5   NA  Ovary    280.6   NA  Testis    325.5   NA  Male Accessory Gland    27.2   25.625  Carcass    26.9 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_21
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039164 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5524-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG5524GD4242 Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of CG5524 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG5524 Class Mutagen Stocks Known lesion CG5524GD4242 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG5524GL00500 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG5524KK102274 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6198 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4242} NA P{KK102274} NA P{TRiP.GL00500} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}EP545 NA P{EPgy2}EY01788b NA P{EPgy2}EY03510 NA miscellaneous insertions P{UASp-YFP.Rab35.Q67L}01 NA
Gene Ontology: Function, Process & Cellular Component ( 1 unique term )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
DNA repair inferred from sequence or structural similarity with UniProtKB:P53692 (FlyBase, 1992-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG5524 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67808 DroID - A comprehensive database of gene and protein interactions. • FBgn0039164 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42876
Orthologs
Genome-wide drosophilid orthologs	Dana\GF18888 Dere\GG12364 Dgri\GH18920 Dmoj\GI23422 Dper\GL24134 Dpse\GA18949 Dsec\GM23503 Dsim\GD18313 Dvir\GJ14526 Dwil\GK11716 Dyak\GE10818
Curated drosophilid orthologs	Dpse\GA18949
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL002581-PA Aedes aegypti (mosquito) AGAP002985-PA Anopheles gambiae (mosquito) XP_001122902.1 Apis mellifera (honey bee) XP_001948837.1 Acyrthosiphon pisum (pea aphid) At5g61460.1 Arabidopsis thaliana (wall cress) 34779 Batrachochytrium dendrobatidis (chytrid fungus) 283349 Branchiostoma floridae (lancelet) BGIBMGA013501-PA Bombyx mori (silk worm) ENSBTAP00000024303 Bos taurus (bovine) CAL0003255 Candida albicans (a form of yeast) CN06973 Caenorhabditis brenneri (small nematode) CBP28121 Caenorhabditis briggsae (nematode) CE18730 Caenorhabditis elegans (worm) ENSCAFP00000034792 Canis familiaris (dog) CAGL0H05071g Candida glabrata (haploid yeast) Chro.80351 Cryptosporidium hominis (obligate parasite) ENSCINP00000015545 Ciona intestinalis (sea squirt) JA16492 Caenorhabditis japonica (nematode) CMA066C Cyanidioschyzon merolae (red alga) cn04237 Cryptococcus neoformans (yeast-like fungus) CPIJ007521 Culex pipens (mosquito) ENSCPOP00000013291 Cavia porcellus (guinea pig) 150721 Chlamidomonas reinhardtii (green alga) RP23489 Caenorhabditis remanei (nematode) 218959 Capitella spl (polychaete worm) DDB0231143 Dictyostelium discoideum (amoeba) DEHA2A05324g Debaryomyces Hansenii (yeast) 318587 Daphnia pulex (daphnia) ENSDARP00000076181 Danio rerio (zebra fish) ENSECAP00000019939 Equus caballus (horse) XP_653814 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000015160 Gymnopilus aculeatus (mushroom) ENSGALP00000026518 Gallus gallus (chicken) GL50803_7648 Giardia lamblia (flagellated protozoan) ENSP00000323439 Homo sapiens (human) ISCW014877-PA Ixodes scapularis (deer tick) KLLA0E05303g Kluyveromyces lactis (yeast) 22018 Monocosta brevicollis (choanoflagellate) ENSMODP00000004772 Monodelphis domestica (gray opossum) ENSMMUP00000015815 Macaca mulatta (rhesus monkey) ENSMUSP00000020931 Mus musculus (house mouse) 113902 Nematostella vectensis (starlet anemone) XP_001608033.1 Nasonia vitripennis (wasp) ENSORLP00000017434 Oryzias latipes (japanese killifish) 33887 Ostreococcus tauri (green alga) PFE1255w Plasmodium falciparum (protozoal parasite) PHUM011504-PA Pediculus humanus (human body louse) PP21435 Pristionchus pacificus (nematode) 210410 Physcomitrella patens (moss) ENSPPYP00000014101 Pongo pygmaeus (orangutan) 86319 Phytophthora ramorum (sudden oak death pathogen) 140481 Phytophthora sojae (root rot pathogen) 145217 Phytophthora sojae (root rot pathogen) 830778 Populus trichocarpa (black cottonwood) ENSPTRP00000052163 Pan troglodytes (chimpanzee) PVX_079985 Plasmodium vivax (protozoal parasite) ENSRNOP00000007073 Rattus norvegicus (norway rat) YLR383W Saccharomyces cerevisiae (budding yeast) SPCC5E4.06 Schizosaccharomyces pombe (fission yeast) 61013 Trichoplax adhaerens (metazoa) TA18975 Theileria annulata (apicomplexan parasite) XP_973544.2 Tribolium castaneum (red flour beetle) ENSTNIP00000001036 Tetraodon nigroviridis (green spotted pufferfish) 1743 Thalassiosira pseudonana (marine diatom) ENSTRUP00000038201 Takifugu rubripes (pufferfish Takifugu) 86245.m00070 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000033941 Xenopus tropicalis (frog) YALI0F02365g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB19016 NV10432 LH24665 ISCW014877 FBgn0228658 FBgn0213727 FBgn0201737 FBgn0189844 FBgn0178370 JGI_V11_318554 JGI_V11_318587 FBgn0078948 FBgn0161724 FBgn0156253 FBgn0146148 FBgn0126387 FBgn0104653 FBgn0095902 CPIJ007521 BGIBMGA013501 ACYPI009689 ACYPI009107 ACYPI002321 GB11194 AGAP002985 AAEL002581 PHUM609400 GLEAN_05764
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	36081 y1 sc* v1; P{TRiP.GL00500}attP2
VDRC	v107055 P{KK102274}VIE-260B v13650 w1118; P{GD4242}v13650/TM3
Genomic Clones ( 1 )
	BACR29F06 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 17 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	SD25546
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	AT01164 bs72g05 CK01.51D.H3 CK01.108D.B2 EC251484 EK042030 EK049713 EK049716 EK053513 EK053516 EK059713 EK059716 EK098137 EK215809 EP13232 FGM232G03
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0039164 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42876
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_142971 RefSeq (Proteins) • NP_651228 DDBJ / EMBL / GenBank • AAF56254 BI641892 Entrez Gene - A searchable database of RefSeq genes. • 42876 UniProtKB/TrEMBL • Q9VCB8
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • RecF/RecN/SMC (IPR003395)
Linkouts
	BioGRID - A database of protein and genetic interactions • 67808 DroID - A comprehensive database of gene and protein interactions. • FBgn0039164 DRSC - Results from RNAi screens. • FBgn0039164 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039164 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5524-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0039164 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42876 InParanoid A subset of ortholog calls from InParanoid. • AAEL002581-PA Aedes aegypti (mosquito) AGAP002985-PA Anopheles gambiae (mosquito) XP_001122902.1 Apis mellifera (honey bee) XP_001948837.1 Acyrthosiphon pisum (pea aphid) At5g61460.1 Arabidopsis thaliana (wall cress) 34779 Batrachochytrium dendrobatidis (chytrid fungus) 283349 Branchiostoma floridae (lancelet) BGIBMGA013501-PA Bombyx mori (silk worm) ENSBTAP00000024303 Bos taurus (bovine) CAL0003255 Candida albicans (a form of yeast) CN06973 Caenorhabditis brenneri (small nematode) CBP28121 Caenorhabditis briggsae (nematode) CE18730 Caenorhabditis elegans (worm) ENSCAFP00000034792 Canis familiaris (dog) CAGL0H05071g Candida glabrata (haploid yeast) Chro.80351 Cryptosporidium hominis (obligate parasite) ENSCINP00000015545 Ciona intestinalis (sea squirt) JA16492 Caenorhabditis japonica (nematode) CMA066C Cyanidioschyzon merolae (red alga) cn04237 Cryptococcus neoformans (yeast-like fungus) CPIJ007521 Culex pipens (mosquito) ENSCPOP00000013291 Cavia porcellus (guinea pig) 150721 Chlamidomonas reinhardtii (green alga) RP23489 Caenorhabditis remanei (nematode) 218959 Capitella spl (polychaete worm) DDB0231143 Dictyostelium discoideum (amoeba) DEHA2A05324g Debaryomyces Hansenii (yeast) 318587 Daphnia pulex (daphnia) ENSDARP00000076181 Danio rerio (zebra fish) ENSECAP00000019939 Equus caballus (horse) XP_653814 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000015160 Gymnopilus aculeatus (mushroom) ENSGALP00000026518 Gallus gallus (chicken) GL50803_7648 Giardia lamblia (flagellated protozoan) ENSP00000323439 Homo sapiens (human) ISCW014877-PA Ixodes scapularis (deer tick) KLLA0E05303g Kluyveromyces lactis (yeast) 22018 Monocosta brevicollis (choanoflagellate) ENSMODP00000004772 Monodelphis domestica (gray opossum) ENSMMUP00000015815 Macaca mulatta (rhesus monkey) ENSMUSP00000020931 Mus musculus (house mouse) 113902 Nematostella vectensis (starlet anemone) XP_001608033.1 Nasonia vitripennis (wasp) ENSORLP00000017434 Oryzias latipes (japanese killifish) 33887 Ostreococcus tauri (green alga) PFE1255w Plasmodium falciparum (protozoal parasite) PHUM011504-PA Pediculus humanus (human body louse) PP21435 Pristionchus pacificus (nematode) 210410 Physcomitrella patens (moss) ENSPPYP00000014101 Pongo pygmaeus (orangutan) 86319 Phytophthora ramorum (sudden oak death pathogen) 140481 Phytophthora sojae (root rot pathogen) 145217 Phytophthora sojae (root rot pathogen) 830778 Populus trichocarpa (black cottonwood) ENSPTRP00000052163 Pan troglodytes (chimpanzee) PVX_079985 Plasmodium vivax (protozoal parasite) ENSRNOP00000007073 Rattus norvegicus (norway rat) YLR383W Saccharomyces cerevisiae (budding yeast) SPCC5E4.06 Schizosaccharomyces pombe (fission yeast) 61013 Trichoplax adhaerens (metazoa) TA18975 Theileria annulata (apicomplexan parasite) XP_973544.2 Tribolium castaneum (red flour beetle) ENSTNIP00000001036 Tetraodon nigroviridis (green spotted pufferfish) 1743 Thalassiosira pseudonana (marine diatom) ENSTRUP00000038201 Takifugu rubripes (pufferfish Takifugu) 86245.m00070 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000033941 Xenopus tropicalis (frog) YALI0F02365g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42876 modMine - Data generated by the modENCODE project. • FBgn0039164 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB19016 NV10432 LH24665 ISCW014877 FBgn0228658 FBgn0213727 FBgn0201737 FBgn0189844 FBgn0178370 JGI_V11_318554 JGI_V11_318587 FBgn0078948 FBgn0161724 FBgn0156253 FBgn0146148 FBgn0126387 FBgn0104653 FBgn0095902 CPIJ007521 BGIBMGA013501 ACYPI009689 ACYPI009107 ACYPI002321 GB11194 AGAP002985 AAEL002581 PHUM609400 GLEAN_05764
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG5524 (Zhang et al., 2007, Keleman et al., 2009.8.5, Wasbrough et al., 2010, Ni et al., 2011.7.19)
Name Synonym
Secondary FlyBase IDs
References ( 18 )
Research paper	Chiolo et al., 2011, Cell 144(5): 732--744 Double-Strand Breaks in Heterochromatin Move Outside of a Dynamic HP1a Domain to Complete Recombinational Repair. [FBrf0213146]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Wasbrough et al., 2010, J. Proteomics 73(11): Supplemental Table 1. Mass spectrometry data. [FBrf0213252] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Zhang et al., 2007, Genetics 176(2): Supplement to Zhang et al., 2007. [FBrf0203184]
Review	Haering and Nasmyth, 2003, BioEssays 25(12): 1178--1191 Building and breaking bridges between sister chromatids. [FBrf0173282] Hirano, 2002, Genes Dev. 16(4): 399--414 The ABCs of SMC proteins: two-armed ATPases for chromosome condensation, cohesion, and repair. [FBrf0146763]
Personal communication to FlyBase	Ni et al., 2011.7.19, TRiP germline vector pVALIUM21. TRiP germline vector pVALIUM21. [FBrf0214641] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Curated genome annotation	Burtis, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126655]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]