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Gene Dmel\Dis3

General Information
Symbol	Dmel\Dis3	Species	D. melanogaster
Name	Dis3	Annotation symbol	CG6413
Feature type	protein_coding_gene	FlyBase ID	FBgn0039183
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	dDis3
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	95F13-95F14	Sequence location	3R:20,159,155..20,162,970 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Dis3 is referred to in FlyBase by the symbol Dmel\Dis3 (CG6413, FBgn0039183). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: 3'-5'-exoribonuclease activity. There is experimental evidence that it is involved in the biological process: regulation of gene expression; nuclear RNA surveillance; neurogenesis. 4 alleles are reported. The phenotype of these alleles is annotated with: mesothoracic tergum. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Nucleotide binding protein, PINc; Ribonuclease II/R; Ribonuclease II/R, conserved site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, during early larval stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1637153_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Dis3. Gene sequence location is 3R:20159155..20162970.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 95F13-95F14   Limits computationally determined from genome sequence between P{PZ}crb07207&P{PZ}BRWD305842 and P{EP}CycB3EP3127
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Dis3 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47 Evidence indicates that 3' UTR overlaps 5' UTR of downstream gene.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Dis3-RA FBtr0084605  NM_142989   3588   982 Dis3-RB FBtr0334599  NM_001275981   3095   982
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Dis3-PA   FBpp0083989   112.2   982   6.67     NP_651246   AAF56281 Dis3-PB   FBpp0306666   112.2   982   6.67     NP_001262910   AGB96290
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ribonuclease II/R (IPR001900) Nucleotide binding protein, PINc (IPR006596) PIN domain (IPR002716) Ribonuclease II/R, conserved site (IPR022966)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA264680   AA390348   AA441222   AE014297 AAF56281   AE014297 AGB96290   AI258777   AI519974   AI533637   AI533679   AI541609   AI543156   AI544432   AJ276897 CAC35051   AW941667   AW944672   AY052150 AAK93574   AY118498 AAM49867   BF504516   BG636839   BG641324   BI173004   BI371595   BT133490   CO280801   EC213662   EC222287   GH748768   GH753604   GH754087   GH758181   GH759658   GH760712   GH761225   GH761332   GH773432   GH775068   GH778025   GH779899   GH781163   GH782953   GH784102   GH785251   GH786475   GH786617   GH787798   GH792819   GH792985   GH794458   GH797864   GH798305   GH798857   GH799704   GH800443   GH801454   GH801999   GH805286   GH807484   GH807891   GH808662   GH814163   GH814478   GH814576   GH815297   GH821826   GH824216   GH825431   GH826925   GH827155   GH827473   GH828748   GH830007   GH833673   GH834223   GH834569   GH834894   GH837983   GH840244   GH842170   GH845174   GH845653   GH846546   GH848002   GH849055   GH849311   GH852320   GH855012   GH855215   GH855294   GH855381   GH857162   GH859513   GH866343   GH871801   GH872396   GH876326   GH877655   GH877734   GH879827   GH881078   GH883358   GH886216   GH887047   GH888001   GH888620   GH889063   GH889147   GH889203   GH889224   GH889675   GH890421   GH891154   GH892453   GH895326   GH897075   GH898184   GH898549   GH899812   GH901324   GH906706   GH911835   GH911925   GH917373   GH918211   GH920228   GH921853   GH926811   GH927641   GH932093   GH932307   GH936387   GH936972   GH937836   GH938289
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VC93 Q9BI20 Q960A7 Q8MSY2
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 6 -- 8   organism | ubiquitous   (Cairrao et al., 2005) mesoderm   (Cairrao et al., 2005) embryonic stage 9 -- 13   organism   (Cairrao et al., 2005) oogenesis stage S3 -- S14   nurse cell   (Cairrao et al., 2005) oogenesis stage S14   oocyte   (Cairrao et al., 2005) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 15   organism   (Cairrao et al., 2005) Comment:0-12 hr AEL larval stage -- adult stage   organism   (Cairrao et al., 2005)
Additional Descriptive Data
	Dis3 transcript can be detected by Northern analysis from 0-12 hrs AEL, but not from 12-20 hrs AEL; expression peaks at 6-8 hrs AEL. Dis3 transcript is also detected during larval, pupal, and adult stages, with a second peak during the first larval instar. Dis3 transcript is detected by in situ hybridization starting at oogenesis stage 3, and is abundant in nurse cells. Maternally deposited transcript is abundant in embryos through cellularization. Dis3 transcript is ubiquituously expressed during gastrulation, and particularly abundant in mesoderm. Expression is less instance by germ band retraction. (Cairrao et al., 2005)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 13   organism   (Cairrao et al., 2005) embryonic stage 6 -- 13   mesoderm   (Cairrao et al., 2005) western blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- third instar larval stage   organism   (Cairrao et al., 2005) adult stage | female   organism   (Cairrao et al., 2005)
Additional Descriptive Data
	Dis3 protein can be detected by Western analysis from 0 hrs AEL through the third larval instar; expression peaks at 6-8 hr AEL, drops sharply at 12-24 hr AEL, and is barely detectable at larval stages. Expression is also detected in female but not male adults. Dis3 protein distribution in embyros is similar to the distribution of Dis3 transcipt; ubiquitous immunoreactivity is observed through germ band retraction, and is more pronounced in mesoderm. (Cairrao et al., 2005)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
nuclear exosome (RNase complex) inferred from direct assay (Andrulis et al., 2002) nuclear lamina inferred from direct assay (Graham et al., 2006) nucleus inferred from direct assay (Graham et al., 2006, Lin et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    54.5 Larval Midgut    16.7 Larval Hindgut    13.7 Larval Malpighian Tubules    15.8 Larval Fat Body    13.7 Larval Salivary Gland    17.7 Larval Trachea    13.275 Larval Carcass    18.8 Adult Head    9.4 Adult Eye    7 Adult Brain    9.7 Adult Thoracic-Abdominal Ganglion    13.8 Adult Crop    15.4 Adult Midgut    12.2 Adult Hindgut    11.4 Adult Malpighian Tubules    16.7 Adult Fat Body    29.3 Adult Salivary Gland    16.6 Adult Heart    12.7 Adult VirginFemale Spermatheca    17 Adult InseminatedFemale Spermatheca    19.6 Adult Ovary    16.3 Adult Testis    3.4 Adult Male Accessory Gland    13.3 Adult Carcass    23.7 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    54.5 Larval Midgut    16.7 Larval Hindgut    13.7 Larval Malpighian Tubules    15.8 Larval Fat Body    13.7 Larval Salivary Gland    17.7 Larval Trachea    13.275 Larval Carcass    18.8 Adult Head    9.4 Adult Eye    7 Adult Brain    9.7 Adult Thoracic-Abdominal Ganglion    13.8 Adult Crop    15.4 Adult Midgut    12.2 Adult Hindgut    11.4 Adult Malpighian Tubules    16.7 Adult Fat Body    29.3 Adult Salivary Gland    16.6 Adult Heart    12.7 Adult VirginFemale Spermatheca    17 Adult InseminatedFemale Spermatheca    19.6 Adult Ovary    16.3 Adult Testis    3.4 Adult Male Accessory Gland    13.3 Adult Carcass    23.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    54.5 Larval Midgut    16.7 Larval Hindgut    13.7 Larval Malpighian Tubules    15.8 Larval Fat Body    13.7 Larval Salivary Gland    17.7 Larval Trachea    13.275 Larval Carcass    18.8 Adult Head    9.4 Adult Eye    7 Adult Brain    9.7 Adult Thoracic-Abdominal Ganglion    13.8 Adult Crop    15.4 Adult Midgut    12.2 Adult Hindgut    11.4 Adult Malpighian Tubules    16.7 Adult Fat Body    29.3 Adult Salivary Gland    16.6 Adult Heart    12.7 Adult VirginFemale Spermatheca    17 Adult InseminatedFemale Spermatheca    19.6 Adult Ovary    16.3 Adult Testis    3.4 Adult Male Accessory Gland    13.3 Adult Carcass    23.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    54.5 Larval Midgut    16.7 Larval Hindgut    13.7 Larval Malpighian Tubules    15.8 Larval Fat Body    13.7 Larval Salivary Gland    17.7 Larval Trachea    13.275 Larval Carcass    18.8 Adult Head    9.4 Adult Eye    7 Adult Brain    9.7 Adult Thoracic-Abdominal Ganglion    13.8 Adult Crop    15.4 Adult Midgut    12.2 Adult Hindgut    11.4 Adult Malpighian Tubules    16.7 Adult Fat Body    29.3 Adult Salivary Gland    16.6 Adult Heart    12.7 Adult VirginFemale Spermatheca    17 Adult InseminatedFemale Spermatheca    19.6 Adult Ovary    16.3 Adult Testis    3.4 Adult Male Accessory Gland    13.3 Adult Carcass    23.7 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    54.5 Larval Midgut    16.7 Larval Hindgut    13.7 Larval Malpighian Tubules    15.8 Larval Fat Body    13.7 Larval Salivary Gland    17.7 Larval Trachea    13.275 Larval Carcass    18.8 Adult Head    9.4 Adult Eye    7 Adult Brain    9.7 Adult Thoracic-Abdominal Ganglion    13.8 Adult Crop    15.4 Adult Midgut    12.2 Adult Hindgut    11.4 Adult Malpighian Tubules    16.7 Adult Fat Body    29.3 Adult Salivary Gland    16.6 Adult Heart    12.7 Adult VirginFemale Spermatheca    17 Adult InseminatedFemale Spermatheca    19.6 Adult Ovary    16.3 Adult Testis    3.4 Adult Male Accessory Gland    13.3 Adult Carcass    23.7 Expression Level Scale  None   Low  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    54.5 Larval Midgut    16.7 Larval Hindgut    13.7 Larval Malpighian Tubules    15.8 Larval Fat Body    13.7 Larval Salivary Gland    17.7 Larval Trachea    13.275 Larval Carcass    18.8 Adult Head    9.4 Adult Eye    7 Adult Brain    9.7 Adult Thoracic-Abdominal Ganglion    13.8 Adult Crop    15.4 Adult Midgut    12.2 Adult Hindgut    11.4 Adult Malpighian Tubules    16.7 Adult Fat Body    29.3 Adult Salivary Gland    16.6 Adult Heart    12.7 Adult VirginFemale Spermatheca    17 Adult InseminatedFemale Spermatheca    19.6 Adult Ovary    16.3 Adult Testis    3.4 Adult Male Accessory Gland    13.3 Adult Carcass    23.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    54.5 Larval Midgut    16.7 Larval Hindgut    13.7 Larval Malpighian Tubules    15.8 Larval Fat Body    13.7 Larval Salivary Gland    17.7 Larval Trachea    13.275 Larval Carcass    18.8 Adult Head    9.4 Adult Eye    7 Adult Brain    9.7 Adult Thoracic-Abdominal Ganglion    13.8 Adult Crop    15.4 Adult Midgut    12.2 Adult Hindgut    11.4 Adult Malpighian Tubules    16.7 Adult Fat Body    29.3 Adult Salivary Gland    16.6 Adult Heart    12.7 Adult VirginFemale Spermatheca    17 Adult InseminatedFemale Spermatheca    19.6 Adult Ovary    16.3 Adult Testis    3.4 Adult Male Accessory Gland    13.3 Adult Carcass    23.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    54.5 Larval Midgut    16.7 Larval Hindgut    13.7 Larval Malpighian Tubules    15.8 Larval Fat Body    13.7 Larval Salivary Gland    17.7 Larval Trachea    13.275 Larval Carcass    18.8 Adult Head    9.4 Adult Eye    7 Adult Brain    9.7 Adult Thoracic-Abdominal Ganglion    13.8 Adult Crop    15.4 Adult Midgut    12.2 Adult Hindgut    11.4 Adult Malpighian Tubules    16.7 Adult Fat Body    29.3 Adult Salivary Gland    16.6 Adult Heart    12.7 Adult VirginFemale Spermatheca    17 Adult InseminatedFemale Spermatheca    19.6 Adult Ovary    16.3 Adult Testis    3.4 Adult Male Accessory Gland    13.3 Adult Carcass    23.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    9.4   NA  Eye    7   NA  Brain    9.7   54.5  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    13.8   NA  Crop    15.4   16.7  Midgut    12.2   13.7  Hindgut    11.4   15.8  Malpighian Tubules    no informative data   no informative data  Fat Body    29.3   17.7  Salivary Gland    no informative data   NA  Heart    12.7   13.275  Trachea    NA   NA  VirginFemale Spermatheca    17   NA  InseminatedFemale Spermatheca    19.6   NA  Ovary    16.3   NA  Testis    3.4   NA  Male Accessory Gland    no informative data   18.8  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    11 central nervous system, pupae P8    3 head, virgin 1-day female    3 head, virgin 4-day female    3 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    4 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    3 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    0 carcass, larvae L3 wandering    9 carcass, 1-day adult    2 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    22 ovary, mated 4-day female    20 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    11 central nervous system, pupae P8    3 head, virgin 1-day female    3 head, virgin 4-day female    3 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    4 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    3 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    0 carcass, larvae L3 wandering    9 carcass, 1-day adult    2 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    22 ovary, mated 4-day female    20 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    11 central nervous system, pupae P8    3 head, virgin 1-day female    3 head, virgin 4-day female    3 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    4 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    3 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    0 carcass, larvae L3 wandering    9 carcass, 1-day adult    2 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    22 ovary, mated 4-day female    20 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    11 central nervous system, pupae P8    3 head, virgin 1-day female    3 head, virgin 4-day female    3 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    4 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    3 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    0 carcass, larvae L3 wandering    9 carcass, 1-day adult    2 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    22 ovary, mated 4-day female    20 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    11 central nervous system, pupae P8    3 head, virgin 1-day female    3 head, virgin 4-day female    3 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    4 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    3 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    0 carcass, larvae L3 wandering    9 carcass, 1-day adult    2 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    22 ovary, mated 4-day female    20 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    11 central nervous system, pupae P8    3 head, virgin 1-day female    3 head, virgin 4-day female    3 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    4 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    3 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    0 carcass, larvae L3 wandering    9 carcass, 1-day adult    2 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    22 ovary, mated 4-day female    20 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    11 central nervous system, pupae P8    3 head, virgin 1-day female    3 head, virgin 4-day female    3 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    4 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    3 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    0 carcass, larvae L3 wandering    9 carcass, 1-day adult    2 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    22 ovary, mated 4-day female    20 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    11 central nervous system, pupae P8    3 head, virgin 1-day female    3 head, virgin 4-day female    3 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    4 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    3 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    0 carcass, larvae L3 wandering    9 carcass, 1-day adult    2 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    22 ovary, mated 4-day female    20 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, during early larval stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    32 embryo 02-04hr    32 embryo 04-06hr    40 embryo 06-08hr    37 embryo 08-10hr    34 embryo 10-12hr    28 embryo 12-14hr    15 embryo 14-16hr    13 embryo 16-18hr    8 embryo 18-20hr    5 embryo 20-22hr    8 embryo 22-24hr    7 larva L1    29 larva L2    15 larva L3 12hr old    12 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    10 white prepupae new    10 white prepupae 12hr    12 white prepupae 24hr    14 pupae 2d postWPP    9 pupae 3d postWPP    4 pupae 4d postWPP    5 adult male 01day    4 adult male 05day    5 adult male 30day    6 adult female 01day    23 adult female 05day    26 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (32) embryo 02-04hr  (32) embryo 04-06hr  (40) embryo 06-08hr  (37) embryo 08-10hr  (34) embryo 10-12hr  (28) embryo 12-14hr    15 embryo 14-16hr    13 embryo 16-18hr    8 embryo 18-20hr    5 embryo 20-22hr    8 embryo 22-24hr    7 larva L1  (29) larva L2    15 larva L3 12hr old    12 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    10 white prepupae new    10 white prepupae 12hr    12 white prepupae 24hr    14 pupae 2d postWPP    9 pupae 3d postWPP    4 pupae 4d postWPP    5 adult male 01day    4 adult male 05day    5 adult male 30day    6 adult female 01day    23 adult female 05day  26 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    32 embryo 02-04hr    32 embryo 04-06hr    40 embryo 06-08hr    37 embryo 08-10hr    34 embryo 10-12hr    28 embryo 12-14hr    15 embryo 14-16hr    13 embryo 16-18hr    8 embryo 18-20hr    5 embryo 20-22hr    8 embryo 22-24hr    7 larva L1    29 larva L2    15 larva L3 12hr old    12 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    10 white prepupae new    10 white prepupae 12hr    12 white prepupae 24hr    14 pupae 2d postWPP    9 pupae 3d postWPP    4 pupae 4d postWPP    5 adult male 01day    4 adult male 05day    5 adult male 30day    6 adult female 01day    23 adult female 05day    26 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    32 embryo 02-04hr    32 embryo 04-06hr    40 embryo 06-08hr    37 embryo 08-10hr    34 embryo 10-12hr    28 embryo 12-14hr    15 embryo 14-16hr    13 embryo 16-18hr    8 embryo 18-20hr    5 embryo 20-22hr    8 embryo 22-24hr    7 larva L1    29 larva L2    15 larva L3 12hr old    12 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    10 white prepupae new    10 white prepupae 12hr    12 white prepupae 24hr    14 pupae 2d postWPP    9 pupae 3d postWPP    4 pupae 4d postWPP    5 adult male 01day    4 adult male 05day    5 adult male 30day    6 adult female 01day    23 adult female 05day    26 adult female 30day    25 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    32 embryo 02-04hr    32 embryo 04-06hr    40 embryo 06-08hr    37 embryo 08-10hr    34 embryo 10-12hr    28 embryo 12-14hr    15 embryo 14-16hr    13 embryo 16-18hr    8 embryo 18-20hr    5 embryo 20-22hr    8 embryo 22-24hr    7 larva L1    29 larva L2    15 larva L3 12hr old    12 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    10 white prepupae new    10 white prepupae 12hr    12 white prepupae 24hr    14 pupae 2d postWPP    9 pupae 3d postWPP    4 pupae 4d postWPP    5 adult male 01day    4 adult male 05day    5 adult male 30day    6 adult female 01day    23 adult female 05day    26 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  32 embryo 02-04hr  32 embryo 04-06hr  (40) embryo 06-08hr  (37) embryo 08-10hr  (34) embryo 10-12hr  28 embryo 12-14hr    15 embryo 14-16hr    13 embryo 16-18hr    8 embryo 18-20hr    5 embryo 20-22hr    8 embryo 22-24hr    7 larva L1  29 larva L2    15 larva L3 12hr old    12 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    10 white prepupae new    10 white prepupae 12hr    12 white prepupae 24hr    14 pupae 2d postWPP    9 pupae 3d postWPP    4 pupae 4d postWPP    5 adult male 01day    4 adult male 05day    5 adult male 30day    6 adult female 01day    23 adult female 05day  26 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    32 embryo 02-04hr    32 embryo 04-06hr    40 embryo 06-08hr    37 embryo 08-10hr    34 embryo 10-12hr    28 embryo 12-14hr    15 embryo 14-16hr    13 embryo 16-18hr    8 embryo 18-20hr    5 embryo 20-22hr    8 embryo 22-24hr    7 larva L1    29 larva L2    15 larva L3 12hr old    12 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    10 white prepupae new    10 white prepupae 12hr    12 white prepupae 24hr    14 pupae 2d postWPP    9 pupae 3d postWPP    4 pupae 4d postWPP    5 adult male 01day    4 adult male 05day    5 adult male 30day    6 adult female 01day    23 adult female 05day    26 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    32 embryo 02-04hr    32 embryo 04-06hr    40 embryo 06-08hr    37 embryo 08-10hr    34 embryo 10-12hr    28 embryo 12-14hr    15 embryo 14-16hr    13 embryo 16-18hr    8 embryo 18-20hr    5 embryo 20-22hr    8 embryo 22-24hr    7 larva L1    29 larva L2    15 larva L3 12hr old    12 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    10 white prepupae new    10 white prepupae 12hr    12 white prepupae 24hr    14 pupae 2d postWPP    9 pupae 3d postWPP    4 pupae 4d postWPP    5 adult male 01day    4 adult male 05day    5 adult male 30day    6 adult female 01day    23 adult female 05day    26 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    34 embryonic 1182-4H    22 embryonic GM2    19 embryonic Kc167    32 embryonic S1    23 embryonic S3    27 leg disc CME L1    28 wing disc CME-W2    25 wing disc ML-DmD8    22 wing disc ML-DmD9    24 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    24 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    33 eye-antennal disc ML-DmD11    25 antennal disc ML-DmD20-c5    29 mixed discs ML-DmD4-c1    31 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    15 ovary fGS/OSS    23 ovary OSC    14 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  26 Schneider line 2 Sg4  (34) embryonic 1182-4H    22 embryonic GM2    19 embryonic Kc167  (32) embryonic S1    23 embryonic S3  (27) leg disc CME L1  (28) wing disc CME-W2    25 wing disc ML-DmD8    22 wing disc ML-DmD9    24 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    24 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3  (33) eye-antennal disc ML-DmD11    25 antennal disc ML-DmD20-c5  (29) mixed discs ML-DmD4-c1  (31) CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    15 ovary fGS/OSS    23 ovary OSC    14 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    34 embryonic 1182-4H    22 embryonic GM2    19 embryonic Kc167    32 embryonic S1    23 embryonic S3    27 leg disc CME L1    28 wing disc CME-W2    25 wing disc ML-DmD8    22 wing disc ML-DmD9    24 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    24 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    33 eye-antennal disc ML-DmD11    25 antennal disc ML-DmD20-c5    29 mixed discs ML-DmD4-c1    31 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    15 ovary fGS/OSS    23 ovary OSC    14 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    34 embryonic 1182-4H    22 embryonic GM2    19 embryonic Kc167    32 embryonic S1    23 embryonic S3    27 leg disc CME L1    28 wing disc CME-W2    25 wing disc ML-DmD8    22 wing disc ML-DmD9    24 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    24 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    33 eye-antennal disc ML-DmD11    25 antennal disc ML-DmD20-c5    29 mixed discs ML-DmD4-c1    31 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    15 ovary fGS/OSS    23 ovary OSC    14 ovary OSS    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    34 embryonic 1182-4H    22 embryonic GM2    19 embryonic Kc167    32 embryonic S1    23 embryonic S3    27 leg disc CME L1    28 wing disc CME-W2    25 wing disc ML-DmD8    22 wing disc ML-DmD9    24 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    24 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    33 eye-antennal disc ML-DmD11    25 antennal disc ML-DmD20-c5    29 mixed discs ML-DmD4-c1    31 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    15 ovary fGS/OSS    23 ovary OSC    14 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  26 Schneider line 2 Sg4  (34) embryonic 1182-4H    22 embryonic GM2    19 embryonic Kc167  32 embryonic S1    23 embryonic S3  27 leg disc CME L1  28 wing disc CME-W2    25 wing disc ML-DmD8    22 wing disc ML-DmD9    24 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    24 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3  (33) eye-antennal disc ML-DmD11    25 antennal disc ML-DmD20-c5  29 mixed discs ML-DmD4-c1  31 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    15 ovary fGS/OSS    23 ovary OSC    14 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    34 embryonic 1182-4H    22 embryonic GM2    19 embryonic Kc167    32 embryonic S1    23 embryonic S3    27 leg disc CME L1    28 wing disc CME-W2    25 wing disc ML-DmD8    22 wing disc ML-DmD9    24 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    24 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    33 eye-antennal disc ML-DmD11    25 antennal disc ML-DmD20-c5    29 mixed discs ML-DmD4-c1    31 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    15 ovary fGS/OSS    23 ovary OSC    14 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    34 embryonic 1182-4H    22 embryonic GM2    19 embryonic Kc167    32 embryonic S1    23 embryonic S3    27 leg disc CME L1    28 wing disc CME-W2    25 wing disc ML-DmD8    22 wing disc ML-DmD9    24 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    24 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    33 eye-antennal disc ML-DmD11    25 antennal disc ML-DmD20-c5    29 mixed discs ML-DmD4-c1    31 CNS ML-DmBG1-c1    22 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    15 ovary fGS/OSS    23 ovary OSC    14 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    4 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    4 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    4 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    4 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    4 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    4 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    4 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    4 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_08 mE1_20_mRNA_expression_cluster_04
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039183 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6413-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal Dis3GD11917 lethal | pupal stage, with Scer\GAL4pnr-MD237 Dis3GD11917 partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 Dis3GD11917 Other Phenotypes Allele neuroanatomy defective | larval stage Dis3GD11917 visible, with Scer\GAL4pnr-MD237 Dis3GD11917 Phenotype manifest in Allele ganglion mother cell | larval stage Dis3GD11917 mesothoracic tergum, with Scer\GAL4pnr-MD237 Dis3GD11917
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of Dis3 Class Mutagen Stocks Known lesion Dis3G5039 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Dis3 Class Mutagen Stocks Known lesion Dis3GD11917 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Dis3KK101473 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Dis3NIG.6413R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6199 (Ryder, 2004.4.26) Df(3R)Exel8178 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11917} NA P{KK101473} NA P{NIG.6413R} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}Dis3G5039 NA
Gene Ontology: Function, Process & Cellular Component ( 10 unique terms )
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
neurogenesis inferred from mutant phenotype (Neumüller et al., 2011) nuclear RNA surveillance inferred from mutant phenotype (Kuan et al., 2009) regulation of gene expression inferred from mutant phenotype (Kiss and Andrulis, 2010)
Cellular Component
CV term Evidence References
nuclear exosome (RNase complex) inferred from direct assay (Andrulis et al., 2002) nuclear lamina inferred from direct assay (Graham et al., 2006) nucleus inferred from direct assay (Graham et al., 2006, Lin et al., 2008)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
3'-5'-exoribonuclease activity inferred from sequence or structural similarity with Saccharomyces DIS3 (Newbury, 2000.3.23, FlyBase, 1992-) RNA binding inferred from electronic annotation with InterPro:IPR001900 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
mRNA processing inferred from sequence or structural similarity with Saccharomyces DIS3 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
cytoplasmic exosome (RNase complex) inferred from sequence or structural similarity with Saccharomyces DIS3 (FlyBase, 1992-) nuclear exosome (RNase complex) inferred from sequence or structural similarity with Saccharomyces DIS3 (FlyBase, 1992-) inferred from sequence or structural similarity with Saccharomyces DIS3 (Andrulis et al., 2002)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene (Graham et al., 2006)
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Dis3 - CG13865 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dis3 - CG6796 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dis3 - CG8671 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dis3 - Csl4 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Dis3 - Mpp6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dis3 - Mtr3 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Dis3 - Rrp4 experimental knowledge based (Guruharsha et al., 2011) Dis3 - Rrp42 experimental knowledge based (Guruharsha et al., 2011) Dis3 - Rrp45 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dis3 - Rrp6 experimental knowledge based (Guruharsha et al., 2011) Dis3 - Ski6 experimental knowledge based (Guruharsha et al., 2011) Dis3 - ana2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Dis3 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67828 DroID - A comprehensive database of gene and protein interactions. • FBgn0039183 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42900
Orthologs
OrthoDB Orthologs (39) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6K3MFK Dipteran inclusive ortholog search EOG6GQQD2 Insect inclusive ortholog search EOG6WDC6P Arthropod inclusive ortholog search EOG62280N Metazoa inclusive ortholog search EOG6NWBC1
Orthologs in Drosophila Species (EOG6K3MFK)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Dis3     Drosophila simulans   Dsim\GD21090 Y   Drosophila sechellia   Dsec\GM26588 Y   Drosophila erecta   Dere\GG11280 Y   Drosophila yakuba   Dyak\GE23472 Y   Drosophila ananassae   Dana\GF20740 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA19573 Y   Drosophila persimilis   Dper\GL21852 Y   Drosophila willistoni   Dwil\GK22331 Y   Drosophila virilis   Dvir\GJ23805 Y   Drosophila mojavensis   Dmoj\GI10069 Y   Drosophila grimshawi   Dgri\GH18811 Y
Orthologs in non-Drosophila Dipterans (EOG6GQQD2)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL011693   Anopheles gambiae Malaria mosquito  Agam\AGAP005191   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ004012
Orthologs in non-Dipteran Insects (EOG6WDC6P)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC413944   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG016533   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH24762   Atta cephalotes Leafcutter ant  Acep\ACEP16980   Camponotus floridanus Florida carpenter ant  Cflo\CFLO23318   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL15356   Linepithema humile Argentine ant  Lhum\LH18468   Pogonomyrmex barbatus Red harvester ant  Pbar\PB16647   Acyrthosiphon pisum Pea aphid  Apim\ACYPI069612   Acyrthosiphon pisum Pea aphid  Apim\ACYPI069446   Bombyx mori Silkmoth  Bmor\BGIBMGA002460   Pediculus humanus Human body louse  Phum\PHUM060160   Tribolium castaneum Red flour beetle  Tcas\TC006450
Orthologs in non-Insect Arthropods (EOG62280N)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_310536   Ixodes scapularis Deer tick  Isca\ISCW012183
Orthologs in non-Arthropod Metazoa (EOG6NWBC1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\dis-3   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_024122gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_014657gn   Danio rerio Zebrafish  Drer\dis3   Xenopus tropicalis Western clawed frog  Xtro\dis3   Gallus gallus Domestic chicken  Ggal\DIS3   Mus musculus House mouse  Mmus\Dis3   Rattus norvegicus Norway rat  Rnor\Dis3   Homo sapiens Human  Hsap\DIS3
Human Orthologs (1)
Gene OMIM HGNC Hsap\DIS3
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD21090 Drosophila sechellia Dsec\GM26588 Drosophila erecta Dere\GG11280 Drosophila yakuba Dyak\GE23472 Drosophila ananassae Dana\GF20740 Drosophila pseudoobscura pseudoobscura Dpse\GA19573 Drosophila persimilis Dper\GL21852 Drosophila willistoni Dwil\GK22331 Drosophila virilis Dvir\GJ23805 Drosophila mojavensis Dmoj\GI10069 Drosophila grimshawi Dgri\GH18811
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	30112 w1118; P{EP}Dis3G5039
VDRC	v108013 P{KK101473}VIE-260B v35090 w1118; P{GD11917}v35090 v35091 w1118; P{GD11917}v35091/TM3
Genomic Clones ( 1 )
	BACR04E17 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 126 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD08354 SD10981
Other clones	FI19082
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT05887 LD08939 LD15969 LD39863 LP02055 RE15735 RE58520 SD05533 SD05579 SD05609 SD09779 SD12644 SD14640
Other clones	41741 102696 EK154910 RP003006593 RP003017380 RP003020329 RP003039409 RP003043216 RP003047905 RP003049308 RP003056667 RP003059859 RP003061338 RP003067376 RP003102378 RP003107593 RP003117443 RP003128360 RP003140773 RP003144810 RP003146970 RP003154807 RP003157781 RP003163586 RP003169510 RP003186497 RP003189752 RP003191904 RP003204406 RP003219347 RP003229634 RP003240890 RP003259986 RP003260629 RP003267473 RP003276187 RP003283828 RP003287480 RP003294257 RP003297076 RP003298502 RP003302138 RP003311472 RP003315645 RP003317858 RP003324015 RP003330802 RP003340321 RP003341407 RP003341414 RP003352803 RP003354017 RP003362798 RP003364487 RP003372441 RP003383290 RP003393062 RP003396129 RP003396388 RP003399310 RP003404520 RP003420208 RP003423020 RP003425382 RP003425983 RP003426165 RP003438765 RP003444840 RP003457080 RP003468664 RP003474398 RP003482699 RP003490730 RP003508883 RP003517724 RP003517838 RP003524488 RP003526907 RP003528507 RP003538478 RP003546243 RP003547434 RP003547588 RP003552088 RP003554091 RP003554572 RP003554925 RP003558772 RP003563545 RP003564128 RP003569520 RP003571162 RP003572309 RP003577903 RP003601487 RP003601640 RP003603766 RP003606026 RP003612796 RP003614366 RP003622855 RP003623996 RP003628239 RP003637767 RP003645032 RP003651841 RP003653771 RP003661694 RP003664592 RP003672473
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0039183 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42900
Antibody Information
	polyclonal (Graham et al., 2009, Cairrao et al., 2005)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Dis3 CG6413 (FlyBase, 1996-)
Source for database merge of
Additional comments	Source for identity of Dis3 CG6413 was sequence comparison (date:010401). (FlyBase, 1996-)
Other Comments
	Identification: as a protein that copurifies with Spt6 protein. (Andrulis et al., 2002)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_142989 NM_001275981 RefSeq (Proteins) • NP_651246 NP_001262910 DDBJ / EMBL / GenBank • AA264680 AAF56281 AAK93574 AAM49867 AGB96290 AI544432 AJ276897 AW941667 AW944672 AY052150 AY118498 CAC35051 Entrez Gene - A searchable database of RefSeq genes. • 42900 UniProtKB/TrEMBL • Q8MSY2 Q9BI20 Q9VC93 Q960A7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ribonuclease II/R (IPR001900) Nucleotide binding protein, PINc (IPR006596) PIN domain (IPR002716) Ribonuclease II/R, conserved site (IPR022966)
Linkouts
	BioGRID - A database of protein and genetic interactions • 67828 DroID - A comprehensive database of gene and protein interactions. • FBgn0039183 DRSC - Results from RNAi screens. • FBgn0039183 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039183 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6413-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0039183 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42900 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42900 modMine - Data generated by the modENCODE project. • FBgn0039183
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	CG6413 (Bhutkar et al., 2008, Andrulis et al., 2002, Cairrao et al., 2005, Graham et al., 2006, Keleman et al., 2009.8.5) dDis3 (Andrulis et al., 2002, Graham et al., 2006, Mamolen and Andrulis, 2009, Graham et al., 2009, Mamolen et al., 2010) Dis3 (Bhutkar et al., 2008, Mendjan et al., 2006, Kuan et al., 2009, Guo et al., 2011, Liu et al., 2011, Graham et al., 2009, Kiss and Andrulis, 2010, Hou et al., 2012, Kiss et al., 2012, Japanese National Institute of Genetics, 2012.5.21) dis3 (Flynt et al., 2010) dRrp44 (Graham et al., 2006) Rrp44 (Guo et al., 2011) taz (Cairrao et al., 2005)
Name Synonym	Dis3   Dis3 ribonuclease (Mamolen and Andrulis, 2009) tazman (Cairrao et al., 2005) Tazman (Lin et al., 2008)
Secondary FlyBase IDs
References ( 35 )
Generate a list of	All references relating to this gene ( 35 )
List References by type	Research paper  ( 18 ) Supplementary material  ( 6 ) Personal communication to FlyBase  ( 7 ) FlyBase analysis  ( 2 ) Stock list  ( 1 ) DNA/RNA sequence record  ( 1 )
Recent research papers ( 5 )
	Lim et al., 2013, Nucleic Acids Res. 41(5): 2963--2980 Genome-wide localization of exosome components to active promoters and chromatin insulators in Drosophila. [FBrf0221054] Hou et al., 2012, BMC Genomics 13: 359 The ribonuclease Dis3 is an essential regulator of the developmental transcriptome. [FBrf0219373] Kiss et al., 2012, Biochem. Biophys. Res. Commun. 423(3): 461--466 Dis3- and exosome subunit-responsive 3' mRNA instability elements. [FBrf0219677] Guo et al., 2011, Mol. Cell. Biol. 31(4): 639--651 Poly(A) Signals Located near the 5' End of Genes Are Silenced by a General Mechanism That Prevents Premature 3'-End Processing. [FBrf0212905] Liu et al., 2011, Curr. Biol. 21(22): 1888--1893 The Exoribonuclease Nibbler Controls 3' End Processing of MicroRNAs in Drosophila. [FBrf0216782] Show all research papers ...