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Gene Dmel\CG5789

General Information
Symbol	Dmel\CG5789	Species	D. melanogaster
Name		Annotation symbol	CG5789
Feature type	protein_coding_gene	FlyBase ID	FBgn0039207
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	96A6-96A7	Sequence location	3R:20,361,926..20,369,629 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG5789 (FBgn0039207). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: xenobiotic-transporting ATPase activity; ATPase activity, coupled to transmembrane movement of substances; transporter activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: transmembrane transport. 4 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: ABC transporter, conserved site; ABC transporter, integral membrane type 1; ABC transporter, transmembrane domain; ABC transporter, transmembrane domain, type 1; ABC transporter-like; ATPase, AAA+ type, core. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval Malpighian tubules. Expression at moderate levels in the following post-embryonic organs or tissues: larval hindgut, larval/adult fat body, adult female reproductive system, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1632273_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG5789. Gene sequence location is 3R:20361926..20369629.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	Sequence features HFA15872 BKN23679
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 96A6-96A7   Limits computationally determined from genome sequence between P{PZ}crb07207&P{PZ}BRWD305842 and P{EP}CycB3EP3127
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG5789 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG5789-RA FBtr0089906  NM_143012   5181   1402 CG5789-RB FBtr0306025     5068   1402
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG5789-PA   FBpp0088845   157.1   1402   6.77     NP_651269   AAF56312 CG5789-PB   FBpp0297167   157.1   1402   6.77
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • ABC transporter, transmembrane domain (IPR001140) ABC transporter-like (IPR003439) ATPase, AAA+ type, core (IPR003593) ABC transporter, transmembrane domain, type 1 (IPR011527) ABC transporter, conserved site (IPR017871) ABC transporter, integral membrane type 1 (IPR017940)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA817337   AA949600   AE014297 AAF56312   AW942976   BI368391   BI573475   BT031161   CL943598   CO278582   CO283314   CO329102   CO331905   EC202078   EC233974   EC251043   EV581309   EV589895   EV596558   EV599130   EW712926   EW712951   EY198957   GH823608   GH840009   GH840522   GH930074
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VC63
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0039207    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0039207 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0039207 expression level Developmental Stage   Expression Level embryo 00-02hr    4248 embryo 02-04hr    4132 embryo 04-06hr    771 embryo 06-08hr    587 embryo 08-10hr    1061 embryo 10-12hr    951 embryo 12-14hr    1361 embryo 14-16hr    1976 embryo 16-18hr    1815 embryo 18-20hr    1039 embryo 20-22hr    1296 embryo 22-24hr    1554 larva L1    1172 larva L2    1198 larva L3 12hr old    601 larva L3 puffstage 1-2    543 larva L3 puffstage 3-6    1698 larva L3 puffstage 7-9    1870 white prepupae new    1357 white prepupae 12hr    809 white prepupae 24hr    555 pupae 2d postWPP    686 pupae 3d postWPP    931 pupae 4d postWPP    1087 adult male 01day    1022 adult male 05day    809 adult male 30day    745 adult female 01day    4116 adult female 05day    5040 adult female 30day    4768 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4248) embryo 02-04hr  (4132) embryo 04-06hr  (771) embryo 06-08hr  (587) embryo 08-10hr  (1061) embryo 10-12hr  (951) embryo 12-14hr  (1361) embryo 14-16hr  (1976) embryo 16-18hr  (1815) embryo 18-20hr  (1039) embryo 20-22hr  (1296) embryo 22-24hr  (1554) larva L1  (1172) larva L2  (1198) larva L3 12hr old  (601) larva L3 puffstage 1-2  (543) larva L3 puffstage 3-6  (1698) larva L3 puffstage 7-9  (1870) white prepupae new  (1357) white prepupae 12hr  (809) white prepupae 24hr  (555) pupae 2d postWPP  (686) pupae 3d postWPP  (931) pupae 4d postWPP  (1087) adult male 01day  (1022) adult male 05day  (809) adult male 30day  (745) adult female 01day  (4116) adult female 05day  (5040) adult female 30day  (4768) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4248) embryo 02-04hr  (4132) embryo 04-06hr    771 embryo 06-08hr    587 embryo 08-10hr    1061 embryo 10-12hr    951 embryo 12-14hr    1361 embryo 14-16hr  (1976) embryo 16-18hr  (1815) embryo 18-20hr    1039 embryo 20-22hr    1296 embryo 22-24hr  (1554) larva L1    1172 larva L2    1198 larva L3 12hr old    601 larva L3 puffstage 1-2    543 larva L3 puffstage 3-6  (1698) larva L3 puffstage 7-9  (1870) white prepupae new    1357 white prepupae 12hr    809 white prepupae 24hr    555 pupae 2d postWPP    686 pupae 3d postWPP    931 pupae 4d postWPP    1087 adult male 01day    1022 adult male 05day    809 adult male 30day    745 adult female 01day  (4116) adult female 05day  (5040) adult female 30day  (4768) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4248 embryo 02-04hr    4132 embryo 04-06hr    771 embryo 06-08hr    587 embryo 08-10hr    1061 embryo 10-12hr    951 embryo 12-14hr    1361 embryo 14-16hr    1976 embryo 16-18hr    1815 embryo 18-20hr    1039 embryo 20-22hr    1296 embryo 22-24hr    1554 larva L1    1172 larva L2    1198 larva L3 12hr old    601 larva L3 puffstage 1-2    543 larva L3 puffstage 3-6    1698 larva L3 puffstage 7-9    1870 white prepupae new    1357 white prepupae 12hr    809 white prepupae 24hr    555 pupae 2d postWPP    686 pupae 3d postWPP    931 pupae 4d postWPP    1087 adult male 01day    1022 adult male 05day    809 adult male 30day    745 adult female 01day    4116 adult female 05day    5040 adult female 30day    4768 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4248 embryo 02-04hr    4132 embryo 04-06hr    771 embryo 06-08hr    587 embryo 08-10hr    1061 embryo 10-12hr    951 embryo 12-14hr    1361 embryo 14-16hr    1976 embryo 16-18hr    1815 embryo 18-20hr    1039 embryo 20-22hr    1296 embryo 22-24hr    1554 larva L1    1172 larva L2    1198 larva L3 12hr old    601 larva L3 puffstage 1-2    543 larva L3 puffstage 3-6    1698 larva L3 puffstage 7-9    1870 white prepupae new    1357 white prepupae 12hr    809 white prepupae 24hr    555 pupae 2d postWPP    686 pupae 3d postWPP    931 pupae 4d postWPP    1087 adult male 01day    1022 adult male 05day    809 adult male 30day    745 adult female 01day    4116 adult female 05day    5040 adult female 30day    4768 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0039207 expression level Developmental Stage   Expression Level embryo 00-02hr    4248 embryo 02-04hr    4132 embryo 04-06hr    771 embryo 06-08hr    587 embryo 08-10hr    1061 embryo 10-12hr    951 embryo 12-14hr    1361 embryo 14-16hr    1976 embryo 16-18hr    1815 embryo 18-20hr    1039 embryo 20-22hr    1296 embryo 22-24hr    1554 larva L1    1172 larva L2    1198 larva L3 12hr old    601 larva L3 puffstage 1-2    543 larva L3 puffstage 3-6    1698 larva L3 puffstage 7-9    1870 white prepupae new    1357 white prepupae 12hr    809 white prepupae 24hr    555 pupae 2d postWPP    686 pupae 3d postWPP    931 pupae 4d postWPP    1087 adult male 01day    1022 adult male 05day    809 adult male 30day    745 adult female 01day    4116 adult female 05day    5040 adult female 30day    4768 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4248) embryo 02-04hr  (4132) embryo 04-06hr  (771) embryo 06-08hr  (587) embryo 08-10hr  (1061) embryo 10-12hr  (951) embryo 12-14hr  (1361) embryo 14-16hr  (1976) embryo 16-18hr  (1815) embryo 18-20hr  (1039) embryo 20-22hr  (1296) embryo 22-24hr  (1554) larva L1  (1172) larva L2  (1198) larva L3 12hr old  (601) larva L3 puffstage 1-2  (543) larva L3 puffstage 3-6  (1698) larva L3 puffstage 7-9  (1870) white prepupae new  (1357) white prepupae 12hr  (809) white prepupae 24hr  (555) pupae 2d postWPP  (686) pupae 3d postWPP  (931) pupae 4d postWPP  (1087) adult male 01day  (1022) adult male 05day  (809) adult male 30day  (745) adult female 01day  (4116) adult female 05day  (5040) adult female 30day  (4768) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4248) embryo 02-04hr  (4132) embryo 04-06hr    771 embryo 06-08hr    587 embryo 08-10hr    1061 embryo 10-12hr    951 embryo 12-14hr    1361 embryo 14-16hr  1976 embryo 16-18hr  1815 embryo 18-20hr    1039 embryo 20-22hr    1296 embryo 22-24hr  1554 larva L1    1172 larva L2    1198 larva L3 12hr old    601 larva L3 puffstage 1-2    543 larva L3 puffstage 3-6  1698 larva L3 puffstage 7-9  1870 white prepupae new    1357 white prepupae 12hr    809 white prepupae 24hr    555 pupae 2d postWPP    686 pupae 3d postWPP    931 pupae 4d postWPP    1087 adult male 01day    1022 adult male 05day    809 adult male 30day    745 adult female 01day  (4116) adult female 05day  (5040) adult female 30day  (4768) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4248 embryo 02-04hr    4132 embryo 04-06hr    771 embryo 06-08hr    587 embryo 08-10hr    1061 embryo 10-12hr    951 embryo 12-14hr    1361 embryo 14-16hr    1976 embryo 16-18hr    1815 embryo 18-20hr    1039 embryo 20-22hr    1296 embryo 22-24hr    1554 larva L1    1172 larva L2    1198 larva L3 12hr old    601 larva L3 puffstage 1-2    543 larva L3 puffstage 3-6    1698 larva L3 puffstage 7-9    1870 white prepupae new    1357 white prepupae 12hr    809 white prepupae 24hr    555 pupae 2d postWPP    686 pupae 3d postWPP    931 pupae 4d postWPP    1087 adult male 01day    1022 adult male 05day    809 adult male 30day    745 adult female 01day    4116 adult female 05day    5040 adult female 30day    4768 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4248 embryo 02-04hr    4132 embryo 04-06hr    771 embryo 06-08hr    587 embryo 08-10hr    1061 embryo 10-12hr    951 embryo 12-14hr    1361 embryo 14-16hr    1976 embryo 16-18hr    1815 embryo 18-20hr    1039 embryo 20-22hr    1296 embryo 22-24hr    1554 larva L1    1172 larva L2    1198 larva L3 12hr old    601 larva L3 puffstage 1-2    543 larva L3 puffstage 3-6    1698 larva L3 puffstage 7-9    1870 white prepupae new    1357 white prepupae 12hr    809 white prepupae 24hr    555 pupae 2d postWPP    686 pupae 3d postWPP    931 pupae 4d postWPP    1087 adult male 01day    1022 adult male 05day    809 adult male 30day    745 adult female 01day    4116 adult female 05day    5040 adult female 30day    4768 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0039207    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0039207 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval Malpighian tubules. Expression at moderate levels in the following post-embryonic organs or tissues: larval hindgut, larval/adult fat body, adult female reproductive system, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0039207 expression level Tissue   Expression Level Larval Central Nervous System    45.75 Larval Midgut    76.6 Larval Hindgut    101.7 Larval Malpighian Tubules    706.7 Larval Fat Body    491.9 Larval Salivary Gland    50.3 Larval Trachea    64.5 Larval Carcass    61.175 Adult Head    63.4 Adult Eye    39.975 Adult Brain    20.8 Adult Thoracic-Abdominal Ganglion    27.6 Adult Crop    99.8 Adult Midgut    79.3 Adult Hindgut    32 Adult Malpighian Tubules    97.7 Adult Fat Body    199.2 Adult Salivary Gland no informative data Adult Heart    84 Adult VirginFemale Spermatheca    128.6 Adult InseminatedFemale Spermatheca    106.4 Adult Ovary    413.2 Adult Testis    60.9 Adult Male Accessory Gland no informative data Adult Carcass    114.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    45.75 Larval Midgut    76.6 Larval Hindgut    101.7 Larval Malpighian Tubules  (706.7) Larval Fat Body    491.9 Larval Salivary Gland    50.3 Larval Trachea    64.5 Larval Carcass    61.175 Adult Head    63.4 Adult Eye    39.975 Adult Brain    20.8 Adult Thoracic-Abdominal Ganglion    27.6 Adult Crop    99.8 Adult Midgut    79.3 Adult Hindgut    32 Adult Malpighian Tubules    97.7 Adult Fat Body    199.2 Adult Salivary Gland no informative data Adult Heart    84 Adult VirginFemale Spermatheca    128.6 Adult InseminatedFemale Spermatheca    106.4 Adult Ovary    413.2 Adult Testis    60.9 Adult Male Accessory Gland no informative data Adult Carcass    114.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    45.75 Larval Midgut    76.6 Larval Hindgut    101.7 Larval Malpighian Tubules    706.7 Larval Fat Body    491.9 Larval Salivary Gland    50.3 Larval Trachea    64.5 Larval Carcass    61.175 Adult Head    63.4 Adult Eye    39.975 Adult Brain    20.8 Adult Thoracic-Abdominal Ganglion    27.6 Adult Crop    99.8 Adult Midgut    79.3 Adult Hindgut    32 Adult Malpighian Tubules    97.7 Adult Fat Body    199.2 Adult Salivary Gland no informative data Adult Heart    84 Adult VirginFemale Spermatheca    128.6 Adult InseminatedFemale Spermatheca    106.4 Adult Ovary    413.2 Adult Testis    60.9 Adult Male Accessory Gland no informative data Adult Carcass    114.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    45.75 Larval Midgut    76.6 Larval Hindgut    101.7 Larval Malpighian Tubules    706.7 Larval Fat Body    491.9 Larval Salivary Gland    50.3 Larval Trachea    64.5 Larval Carcass    61.175 Adult Head    63.4 Adult Eye    39.975 Adult Brain    20.8 Adult Thoracic-Abdominal Ganglion    27.6 Adult Crop    99.8 Adult Midgut    79.3 Adult Hindgut    32 Adult Malpighian Tubules    97.7 Adult Fat Body    199.2 Adult Salivary Gland no informative data Adult Heart    84 Adult VirginFemale Spermatheca    128.6 Adult InseminatedFemale Spermatheca    106.4 Adult Ovary    413.2 Adult Testis    60.9 Adult Male Accessory Gland no informative data Adult Carcass    114.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0039207 expression level Tissue   Expression Level Larval Central Nervous System    45.75 Larval Midgut    76.6 Larval Hindgut    101.7 Larval Malpighian Tubules    706.7 Larval Fat Body    491.9 Larval Salivary Gland    50.3 Larval Trachea    64.5 Larval Carcass    61.175 Adult Head    63.4 Adult Eye    39.975 Adult Brain    20.8 Adult Thoracic-Abdominal Ganglion    27.6 Adult Crop    99.8 Adult Midgut    79.3 Adult Hindgut    32 Adult Malpighian Tubules    97.7 Adult Fat Body    199.2 Adult Salivary Gland no informative data Adult Heart    84 Adult VirginFemale Spermatheca    128.6 Adult InseminatedFemale Spermatheca    106.4 Adult Ovary    413.2 Adult Testis    60.9 Adult Male Accessory Gland no informative data Adult Carcass    114.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    45.75 Larval Midgut    76.6 Larval Hindgut    101.7 Larval Malpighian Tubules  706.7 Larval Fat Body    491.9 Larval Salivary Gland    50.3 Larval Trachea    64.5 Larval Carcass    61.175 Adult Head    63.4 Adult Eye    39.975 Adult Brain    20.8 Adult Thoracic-Abdominal Ganglion    27.6 Adult Crop    99.8 Adult Midgut    79.3 Adult Hindgut    32 Adult Malpighian Tubules    97.7 Adult Fat Body    199.2 Adult Salivary Gland no informative data Adult Heart    84 Adult VirginFemale Spermatheca    128.6 Adult InseminatedFemale Spermatheca    106.4 Adult Ovary    413.2 Adult Testis    60.9 Adult Male Accessory Gland no informative data Adult Carcass    114.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    45.75 Larval Midgut    76.6 Larval Hindgut    101.7 Larval Malpighian Tubules    706.7 Larval Fat Body    491.9 Larval Salivary Gland    50.3 Larval Trachea    64.5 Larval Carcass    61.175 Adult Head    63.4 Adult Eye    39.975 Adult Brain    20.8 Adult Thoracic-Abdominal Ganglion    27.6 Adult Crop    99.8 Adult Midgut    79.3 Adult Hindgut    32 Adult Malpighian Tubules    97.7 Adult Fat Body    199.2 Adult Salivary Gland no informative data Adult Heart    84 Adult VirginFemale Spermatheca    128.6 Adult InseminatedFemale Spermatheca    106.4 Adult Ovary    413.2 Adult Testis    60.9 Adult Male Accessory Gland no informative data Adult Carcass    114.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    45.75 Larval Midgut    76.6 Larval Hindgut    101.7 Larval Malpighian Tubules    706.7 Larval Fat Body    491.9 Larval Salivary Gland    50.3 Larval Trachea    64.5 Larval Carcass    61.175 Adult Head    63.4 Adult Eye    39.975 Adult Brain    20.8 Adult Thoracic-Abdominal Ganglion    27.6 Adult Crop    99.8 Adult Midgut    79.3 Adult Hindgut    32 Adult Malpighian Tubules    97.7 Adult Fat Body    199.2 Adult Salivary Gland no informative data Adult Heart    84 Adult VirginFemale Spermatheca    128.6 Adult InseminatedFemale Spermatheca    106.4 Adult Ovary    413.2 Adult Testis    60.9 Adult Male Accessory Gland no informative data Adult Carcass    114.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    63.4   NA  Eye    39.975   NA  Brain    20.8   45.75  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    27.6   NA  Crop    99.8   76.6  Midgut    79.3   101.7  Hindgut    32   706.7  Malpighian Tubules    97.7   491.9  Fat Body    199.2   50.3  Salivary Gland    no informative data   NA  Heart    84   64.5  Trachea    NA   NA  VirginFemale Spermatheca    128.6   NA  InseminatedFemale Spermatheca    106.4   NA  Ovary    413.2   NA  Testis    60.9   NA  Male Accessory Gland    no informative data   61.175  Carcass    114.4 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_26
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039207 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5789-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 CG5789GD238 viable CG5789EY13911 Sterility Allele fertile CG5789EY13911 Phenotype manifest in Allele
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of CG5789 Class Mutagen Stocks Known lesion CG5789CB-5361-3 1 -- CG5789EY13911 P-element activity 1 -- CG5789KG07791 1 --
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG5789 Class Mutagen Stocks Known lesion CG5789GD238 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel7357 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD238} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}CG13624EP3546 NA P{EP}EP820 NA P{EP}EP3065 NA P{EPgy2}CG5789EY13911 NA miscellaneous insertions P{RS3}CG5789CB-5361-3 NA P{SUPor-P}CG5789KG07791 NA
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 7 terms )
Molecular Function
CV term Evidence References
ATPase activity, coupled to transmembrane movement of substances inferred from sequence or structural similarity with EMBL:AF027302 (FlyBase, 1992-) ATP binding inferred from electronic annotation with InterPro:IPR001140, InterPro:IPR003439, InterPro:IPR011527, InterPro:IPR017871 (FlyBase Curators et al., 2004-) transporter activity inferred from sequence or structural similarity with EMBL:AF027302 (FlyBase, 1992-) xenobiotic-transporting ATPase activity inferred from sequence or structural similarity with EMBL:AF022908 (FlyBase, 1992-)
Biological Process
CV term Evidence References
transmembrane transport inferred from electronic annotation with InterPro:IPR001140, InterPro:IPR011527 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
ATP-binding cassette (ABC) transporter complex inferred from sequence or structural similarity with EMBL:AF022908 (FlyBase, 1992-) integral to membrane inferred from electronic annotation with InterPro:IPR001140, InterPro:IPR011527 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG5789 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67854 DroID - A comprehensive database of gene and protein interactions. • FBgn0039207 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42928
Orthologs
Genome-wide drosophilid orthologs	Dana\GF20707 Dere\GG12337 Dgri\GH18781 Dmoj\GI22672 Dper\GL21974 Dpse\GA19130 Dsec\GM23478 Dsim\GD18286 Dwil\GK14306 Dyak\GE10791
Curated drosophilid orthologs	Dpse\GA19130
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL005929-PA Aedes aegypti (mosquito) AGAP003221-PA Anopheles gambiae (mosquito) XP_397395.3 Apis mellifera (honey bee) CPIJ001311 Culex pipens (mosquito) XP_001603263.1 Nasonia vitripennis (wasp) XP_969849.1 Tribolium castaneum (red flour beetle) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB18184 PB12060 PB11368 NV18247 NV17018 NV16518 NV16516 NV13919 NV13439 NV12728 NV12725 NV12660 NV12659 NV12592 NV10689 LH25761 LH12079 LH22565 ISCW019069 FBgn0242196 FBgn0230914 FBgn0230912 FBgn0230720 FBgn0228867 FBgn0228632 FBgn0226812 FBgn0226811 FBgn0226679 FBgn0226678 FBgn0216312 FBgn0064283 FBgn0210501 FBgn0198818 FBgn0198807 FBgn0197471 FBgn0195525 FBgn0193087 FBgn0191577 FBgn0189819 FBgn0181740 FBgn0178345 FBgn0178156 FBgn0172218 FBgn0172217 FBgn0167954 JGI_V11_330093 FBgn0247232 FBgn0081645 FBgn0079127 FBgn0078266 FBgn0076495 FBgn0163463 FBgn0159567 FBgn0156509 FBgn0156507 FBgn0145400 FBgn0135776 FBgn0133094 FBgn0133058 FBgn0051793 FBgn0051792 FBgn0038740 FBgn0032908 FBgn0032026 FBgn0130788 FBgn0126248 FBgn0118368 FBgn0118367 FBgn0115600 FBgn0113713 FBgn0113329 FBgn0113328 FBgn0108047 FBgn0104627 FBgn0101213 FBgn0097713 FBgn0094372 FBgn0091716 FBgn0091715 FBgn0091714 CPIJ016918 CPIJ004604 CPIJ001311 BGIBMGA007735 ACYPI008842 ACYPI008595 ACYPI008319 ACYPI007210 ACYPI006979 ACYPI006442 ACYPI005339 ACYPI004675 ACYPI004533 ACYPI002363 ACYPI001507 ACYPI001390 ACYPI000359 GB30033 GB17987 GB16790 GB11089 AGAP006427 AGAP003221 AAEL013854 AAEL013567 AAEL005929 PHUM075990 GLEAN_10434 GLEAN_09892 GLEAN_09891 GLEAN_08570 GLEAN_06468 GLEAN_06467 GLEAN_13749 GLEAN_13750 GLEAN_13751 GLEAN_13752 GLEAN_14089 GLEAN_14090 GLEAN_14091 GLEAN_14092 GLEAN_14379 GLEAN_14380 GLEAN_14383 GLEAN_14384 GLEAN_14385 GLEAN_14386 GLEAN_14403 GLEAN_14589 GLEAN_14776 GLEAN_14880 GLEAN_15346 GLEAN_15423 GLEAN_15918
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	20898 y1 w67c23; P{EPgy2}CG5789EY13911 14558 y1 w67c23; ry506 P{SUPor-P}CG5789KG07791
Kyoto	123587 w1118; P{RS3}CG5789CB-5361-3
VDRC	v1204 w1118 P{GD238}v1204
Genomic Clones ( 2 )
	BACR13M04 BACR47D16 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 20 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE51716
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE54356 RH09106
Other clones	43542 99063 274175 Dmel_dig_011025_0646_0623 Dmel_neb_003026_0871_3632 Dmel_neb_012160_0367_0809 Dmel_neb_013213_0942_1867 EK130504 EK162832 EK292032 EK301960 LD22585 LD29556 RP003273541 RP003448904 RP003516307 RP003538242
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0039207 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42928
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_143012 RefSeq (Proteins) • NP_651269 DDBJ / EMBL / GenBank • AA949600 AAF56312 AW942976 CL943598 Entrez Gene - A searchable database of RefSeq genes. • 42928 UniProtKB/TrEMBL • Q9VC63
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • ABC transporter, transmembrane domain (IPR001140) ABC transporter-like (IPR003439) ATPase, AAA+ type, core (IPR003593) ABC transporter, transmembrane domain, type 1 (IPR011527) ABC transporter, conserved site (IPR017871) ABC transporter, integral membrane type 1 (IPR017940)
Linkouts
	BioGRID - A database of protein and genetic interactions • 67854 DroID - A comprehensive database of gene and protein interactions. • FBgn0039207 DRSC - Results from RNAi screens. • FBgn0039207 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039207 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5789-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0039207 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42928 InParanoid A subset of ortholog calls from InParanoid. • AAEL005929-PA Aedes aegypti (mosquito) AGAP003221-PA Anopheles gambiae (mosquito) XP_397395.3 Apis mellifera (honey bee) CPIJ001311 Culex pipens (mosquito) XP_001603263.1 Nasonia vitripennis (wasp) XP_969849.1 Tribolium castaneum (red flour beetle) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42928 modMine - Data generated by the modENCODE project. • FBgn0039207 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB18184 PB12060 PB11368 NV18247 NV17018 NV16518 NV16516 NV13919 NV13439 NV12728 NV12725 NV12660 NV12659 NV12592 NV10689 LH25761 LH12079 LH22565 ISCW019069 FBgn0242196 FBgn0230914 FBgn0230912 FBgn0230720 FBgn0228867 FBgn0228632 FBgn0226812 FBgn0226811 FBgn0226679 FBgn0226678 FBgn0216312 FBgn0064283 FBgn0210501 FBgn0198818 FBgn0198807 FBgn0197471 FBgn0195525 FBgn0193087 FBgn0191577 FBgn0189819 FBgn0181740 FBgn0178345 FBgn0178156 FBgn0172218 FBgn0172217 FBgn0167954 JGI_V11_330093 FBgn0247232 FBgn0081645 FBgn0079127 FBgn0078266 FBgn0076495 FBgn0163463 FBgn0159567 FBgn0156509 FBgn0156507 FBgn0145400 FBgn0135776 FBgn0133094 FBgn0133058 FBgn0051793 FBgn0051792 FBgn0038740 FBgn0032908 FBgn0032026 FBgn0130788 FBgn0126248 FBgn0118368 FBgn0118367 FBgn0115600 FBgn0113713 FBgn0113329 FBgn0113328 FBgn0108047 FBgn0104627 FBgn0101213 FBgn0097713 FBgn0094372 FBgn0091716 FBgn0091715 FBgn0091714 CPIJ016918 CPIJ004604 CPIJ001311 BGIBMGA007735 ACYPI008842 ACYPI008595 ACYPI008319 ACYPI007210 ACYPI006979 ACYPI006442 ACYPI005339 ACYPI004675 ACYPI004533 ACYPI002363 ACYPI001507 ACYPI001390 ACYPI000359 GB30033 GB17987 GB16790 GB11089 AGAP006427 AGAP003221 AAEL013854 AAEL013567 AAEL005929 PHUM075990 GLEAN_10434 GLEAN_09892 GLEAN_09891 GLEAN_08570 GLEAN_06468 GLEAN_06467 GLEAN_13749 GLEAN_13750 GLEAN_13751 GLEAN_13752 GLEAN_14089 GLEAN_14090 GLEAN_14091 GLEAN_14092 GLEAN_14379 GLEAN_14380 GLEAN_14383 GLEAN_14384 GLEAN_14385 GLEAN_14386 GLEAN_14403 GLEAN_14589 GLEAN_14776 GLEAN_14880 GLEAN_15346 GLEAN_15423 GLEAN_15918
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	CG5789 (Arancio et al., 2010, Mayer et al., 2009) Dme_CG5789 (Tarnay et al., 2004)
Name Synonym
Secondary FlyBase IDs
References ( 18 )
Research paper	Arancio et al., 2010, Genetics 185(1): 129--140 The nucleosome remodeling factor ISWI functionally interacts with an evolutionarily conserved network of cellular factors. [FBrf0213976] Mayer et al., 2009, J. Neurosci. 29(11): 3538--3550 Evolutionary conservation of vertebrate blood-brain barrier chemoprotective mechanisms in Drosophila. [FBrf0207483] Tarnay et al., 2004, Insect Molec. Biol. 13(5): 539--548 The dMRP/CG6214 gene of Drosophila is evolutionarily and functionally related to the human multidrug resistance-associated protein family. [FBrf0180349] Herold et al., 2003, EMBO J. 22(10): 2472--2483 Genome-wide analysis of nuclear mRNA export pathways in Drosophila. [FBrf0158900]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Review	Dean et al., 2001, Genome Res. 11: 1156--1166 The human ATP-binding cassette (ABC) transporter superfamily. [FBrf0159553]
Personal communication to FlyBase	Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
FlyBase analysis	FlyBase Curators, 2008, Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. [FBrf0202955] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]
Curated genome annotation	Ketchum, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126677]