Basic leucine zipper (bZIP) domain transcription factor - together with its binding partner encoded by REPTOR-BP, mediates much of the transcriptional response observed upon Tor complex 1 inhibition - plays critical roles in maintaining energy homeostasis and promoting animal survival upon nutrient restriction
Please see the JBrowse view of Dmel\REPTOR for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Gene model reviewed during 5.46
Gene model reviewed during 5.55
Interacts (via C-terminus) with REPTOR-BP (via C-terminus). Interacts with the TORC1 complex component raptor. Interacts (when phosphorylated) with 14-3-3zeta, this interaction may assist its cytoplasmic retention.
Phosphorylation by the TORC1 kinase complex at Ser-527 and Ser-530 abolishes nuclear localization. Upon TORC1 inhibition, dephosphorylated in a mts/PP2a-dependent manner leading to nuclear localization.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\REPTOR using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as ventral nerve cord anlage
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
JBrowse - Visual display of RNA-Seq signals
View Dmel\REPTOR in JBrowse3-85
3-84.0
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: CG13624 anon-WO0153538.65
l(3)rI809 may correspond to REPTOR: the P{PZ}l(3)rI809rI809 insertion maps within the transcription unit.
Source for merge of CG13624 anon-WO0153538.65 was sequence comparison ( date:051113 ).
Source for identity of: REPTOR CG13624