FlyBase Gene Report: Dmel\atl

General Information

Symbol

Dmel\atl

Species

D. melanogaster

Name

atlastin

Annotation Symbol

CG6668

Feature Type

protein_coding_gene

FlyBase ID

FBgn0039213

Gene Model Status

Current

Stock Availability

14 publicly available

Gene Snapshot

atlastin (atl) encodes a dynamin-like membrane-bound GTPase that mediates endoplasmic reticulum membrane fusion in a GTP-dependent fashion. It is required for normal growth of muscles and synapses at the neuromuscular junction. [Date last reviewed: 2018-11-08]

Other Summaries

Alliance
Auto summary
UniProtKB
Interactive Fly

Also Known As

D-atlastin, dAtl

Key Links

Genomic Location

Cytogenetic map

96A13-96A13

Sequence location

3R:24,625,671..24,634,714 [+]

Recombination map

3-85

RefSeq locus

NT_033777 REGION:24625671..24634714

Sequence

Get Decorated FASTA

Genomic Maps

GBrowse JBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

[Detailed GO annotations]

Protein Family (UniProt)

Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily. (Q9VC57)

Protein Signatures (InterPro)

Molecular Function (GO)
[Detailed GO annotations]

Experimental Evidence

GTP binding; GTPase activity; guanyl ribonucleotide binding; identical protein binding; protein binding

Predictions / Assertions

GTP binding; GTPase activity

Summaries

Protein Function (UniProtKB)

GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate microtubule polymerization and Golgi biogenesis. Required for dopaminergic neurons survival and the growth of muscles and synapses at neuromuscular junctions.

(UniProt, Q9VC57)

Summary (Interactive Fly)

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the GBrowse view of Dmel\atl or the JBrowse view of Dmel\atl for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Gene model reviewed during 5.49

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

atl-RA

FBtr0084656

NM_143017

2889

541

atl-RB

FBtr0084657

NM_170157

3207

541

atl-RC

FBtr0345218

NM_001300577

2907

541

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

atl-PA

FBpp0084036

60.9

541

6.51

NP_651274

AAF56318

atl-PB

FBpp0084037

60.9

541

6.51

NP_733020

AAN14008

atl-PC

FBpp0311413

60.9

541

6.51

NP_001287506

AHN57505

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

541 aa isoforms: atl-PA, atl-PB, atl-PC

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Homooligomer; trans-homooligomer between proteins on adjacent membranes. Interacts with spas; interaction may regulate microtubule dynamics.

(UniProt, Q9VC57)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\atl using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

atl_1
atl_2

Linkouts

Gene Ontology (24 terms)

Molecular Function (5 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

GTP binding

inferred from mutant phenotype

(assigned by UniProt )

(Orso et al., 2009)

GTPase activity

inferred from direct assay

(Orso et al., 2009)

inferred from mutant phenotype

(Bian et al., 2011)

guanyl ribonucleotide binding

inferred from mutant phenotype

(Bian et al., 2011)

identical protein binding

inferred from direct assay

(assigned by UniProt )

(Orso et al., 2009)

protein binding

inferred from physical interaction with UniProtKB:Q8I0P1

(assigned by UniProt )

(Lee et al., 2009)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

GTP binding

inferred from biological aspect of ancestor with PANTHER:PTN000079086

(assigned by GO_Central )

(Gaudet et al., 2011)

GTPase activity

inferred from biological aspect of ancestor with PANTHER:PTN000079086

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (12 terms)

Terms Based on Experimental Evidence (12 terms)

CV Term

Evidence

References

endoplasmic reticulum membrane fusion

inferred from direct assay

(Orso et al., 2009)

inferred from mutant phenotype

(Orso et al., 2009)

endoplasmic reticulum organization

inferred from mutant phenotype

(assigned by UniProt )

(Lee et al., 2009, Orso et al., 2009)

inferred from mutant phenotype

(Summerville et al., 2016)

Golgi organization

inferred from mutant phenotype

(assigned by UniProt )

(Lee et al., 2009)

membrane fusion

inferred from direct assay

(Klemm et al., 2013, Bian et al., 2011)

inferred from direct assay

(assigned by UniProt )

(Orso et al., 2009)

microtubule depolymerization

inferred from mutant phenotype

(assigned by UniProt )

(Lee et al., 2009)

muscle organ development

inferred from mutant phenotype

(assigned by UniProt )

(Lee et al., 2009)

neuromuscular junction development

inferred from mutant phenotype

(Lee et al., 2009)

positive regulation of axon extension involved in regeneration

inferred from mutant phenotype

(Rao et al., 2016)

protein homooligomerization

inferred from direct assay

(assigned by UniProt )

(Orso et al., 2009)

regulation of microtubule depolymerization

inferred from mutant phenotype

(Lee et al., 2009)

regulation of synaptic growth at neuromuscular junction

inferred from mutant phenotype

(Lee et al., 2009)

synaptic growth at neuromuscular junction

inferred from mutant phenotype

(assigned by UniProt )

(Lee et al., 2009)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

endoplasmic reticulum organization

inferred from biological aspect of ancestor with PANTHER:PTN000844237

(assigned by GO_Central )

(Gaudet et al., 2011)

protein homooligomerization

inferred from biological aspect of ancestor with PANTHER:PTN000844237

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (7 terms)

Terms Based on Experimental Evidence (7 terms)

CV Term

Evidence

References

cytoplasm

inferred from direct assay

(Lee et al., 2008)

endomembrane system

inferred from high throughput direct assay

(Tan et al., 2009)

endoplasmic reticulum

inferred from direct assay

(assigned by UniProt )

(Orso et al., 2009)

inferred from direct assay

(Lee et al., 2009)

Golgi apparatus

inferred from direct assay

(Lee et al., 2009)

intrinsic component of endoplasmic reticulum membrane

inferred from direct assay

(Orso et al., 2009)

membrane

inferred from direct assay

(assigned by UniProt )

(Orso et al., 2009)

colocalizes_with microtubule

inferred from direct assay

(assigned by UniProt )

(Lee et al., 2009)

Terms Based on Predictions or Assertions (0 terms)

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

• cytoplasm | basal

Comment: apically cleared

(Fisher et al., 2012)

embryonic stage 9 -- 10

anterior endoderm

(Fisher et al., 2012)

inclusive hindgut primordium

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 11 -- 12

anterior midgut primordium

(Fisher et al., 2012)

foregut primordium

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

salivary gland body primordium

(Fisher et al., 2012)

somatic muscle primordium

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

visceral muscle primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic dorsal epidermis

(Fisher et al., 2012)

embryonic foregut

(Fisher et al., 2012)

embryonic head epidermis

(Fisher et al., 2012)

embryonic hindgut

(Fisher et al., 2012)

embryonic ventral epidermis

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

embryonic/larval brain

(Lee et al., 2008)

ventral nerve cord

(Lee et al., 2008)

embryonic/larval somatic muscle

(Lee et al., 2008)

oogenesis stage S5 -- S6

nurse cell

• membrane

(Lee et al., 2008)

nurse cell

• cytoplasm

(Lee et al., 2008)

egg chamber | posterior

(Lee et al., 2008)

oogenesis stage S9

oocyte

• cytoplasm | anterior

(Lee et al., 2008)

oogenesis stage S10

follicle cell

(Lee et al., 2008)

adult stage

adult brain | ubiquitous

(Lee et al., 2008)

dopaminergic neuron | subset of adult brain

(Lee et al., 2008)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

atl is detected in neuropil regions of the brain and ventral nerve cord of third instar larvae. It is also detected in motor axon bundles emanating from the ventral ganglia. It is highly expressed throughout the cytolasm of body wall muscles and present at lower levels in the proximal parts of presynaptic arbors. It is not present in synaptic boutons.

(Lee et al., 2008)

In early oogenesis, atl protein is expressed in the posterior compartment of the egg chamber and in the membrane and cytoplasm of nurse cells. At oogenesis stage 9 it is found in the anterior cytoplasm of the oocyte. It then disapeears from this domain and at stage 10 atl protein is strongly expressed in follicle cells. In the adult brain it is expressed ubiquitously, with some cellls, including a subset of dopaminergic neurons expressing atl strongly.

(Lee et al., 2008)

Marker for

Subcellular Localization

CV Term

Evidence

References

cytoplasm

inferred from direct assay

(Lee et al., 2008)

endomembrane system

inferred from high throughput direct assay

(Tan et al., 2009)

endoplasmic reticulum

inferred from direct assay

(assigned by UniProt )

(Orso et al., 2009)

inferred from direct assay

(Lee et al., 2009)

Golgi apparatus

inferred from direct assay

(Lee et al., 2009)

intrinsic component of endoplasmic reticulum membrane

inferred from direct assay

(Orso et al., 2009)

membrane

inferred from direct assay

(assigned by UniProt )

(Orso et al., 2009)

colocalizes_with microtubule

inferred from direct assay

(assigned by UniProt )

(Lee et al., 2009)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\atl in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\atl

View exonic expression by tissue for Dmel\atl

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0039213

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0039213

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG6668-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6668

Flygut - An atlas of the Drosophila adult midgut

FBgn0039213

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\atl

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 16 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 10 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of atl

Transgenic constructs containing regulatory region of atl

Deletions and Duplications ( 1 )

Disrupted in

Df(3R)Exel7357

(Lee et al., 2009, Ryder, 2004.4.26)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

atl^GD242

lethal, with Scer\GAL4^GMR.PF

atl^GD242

lethal, with Scer\GAL4^ple.PF

atl^GD242

lethal, with Scer\GAL4^pnr-MD237

atl^GD242

lethal, with Scer\GAL4^unspecified

atl^UAS.Tag:MYC

lethal | pupal stage, with Scer\GAL4^pnr-MD237

atl^GD242

lethal - all die before end of pupal stage (with Df(3R)Exel7357)

atl²

lethal - all die before end of pupal stage | recessive

atl²

lethal - all die during embryonic stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

atl^GD242

lethal - all die during larval stage, with Scer\GAL4^Mef2.PR

atl^GD242

viable

viable, with Scer\GAL4^tin.CΔ4

atl^GD242

Sterility

Allele

fertile

sterile | recessive

Other Phenotypes

Allele

bang sensitive

atl¹

bang sensitive, with Scer\GAL4^ple.PF

increased mortality | adult stage | calorie restriction conditional, with Scer\GAL4^Cg.PA

atl^GD242

locomotor behavior defective

atl¹

locomotor behavior defective | adult stage | progressive, with Scer\GAL4^elav-C155

atl^dsRNA.UAS

neuroanatomy defective | larval stage

atl²

neuroanatomy defective | larval stage, with Scer\GAL4^C57

atl^R192Q.UAS

neuroanatomy defective | larval stage (with Df(3R)Exel7357)

atl²

neuroanatomy defective | third instar larval stage

atl²

neuroanatomy defective | third instar larval stage, with Scer\GAL4^elav-C155

atl^dsRNA.UAS

neuroanatomy defective | third instar larval stage, with Scer\GAL4^nSyb.PS

neuroanatomy defective | third instar larval stage, with Scer\GAL4^Toll-6-D42

atl^UAS.Tag:MYC

neurophysiology defective | third instar larval stage

atl²

neurophysiology defective | third instar larval stage, with Scer\GAL4^elav-C155

atl^dsRNA.UAS

neurophysiology defective | third instar larval stage, with Scer\GAL4^nSyb.PS

atl^{K51A.UAS.Tag:MYC}

neurophysiology defective | third instar larval stage, with Scer\GAL4^Toll-6-D42

short lived

atl¹

size defective | adult stage, with Scer\GAL4^GMR.PF

atl^UAS.Tag:MYC

size defective | dominant | larval stage

atl²

size defective | larval stage, with Scer\GAL4²²¹

size defective | larval stage, with Scer\GAL4^Cg.PA

atl^GD242

small body | adult stage

atl¹

small body | larval stage (with Df(3R)Exel7357)

atl²

small body | pupal stage

atl¹

small body | recessive

atl²

some die during pupal stage (with Df(3R)Exel7357)

atl²

some die during pupal stage | recessive

atl²

starvation stress response defective | adult stage, with Scer\GAL4^Cg.PA

atl^GD242

visible | adult stage, with Scer\GAL4^ey.PH

atl^UAS.Tag:MYC

visible | adult stage, with Scer\GAL4^GMR.PF

atl^UAS.Tag:MYC

wound healing defective | dominant | larval stage

atl²

wound healing defective | larval stage, with Scer\GAL4²²¹

Phenotype manifest in

Allele

abdominal 2 ventral longitudinal muscle 3 (with Df(3R)Exel7357)

atl²

abdominal 2 ventral longitudinal muscle 4 (with Df(3R)Exel7357)

atl²

axon | larval stage

atl²

axon | larval stage, with Scer\GAL4²²¹

dopaminergic neuron

atl¹

dopaminergic neuron, with Scer\GAL4^ple.PF

embryonic/larval fat body | larval stage, with Scer\GAL4^Cg.PA

atl^GD242

embryonic/larval motor neuron | third instar larval stage

atl²

embryonic/larval motor neuron | third instar larval stage, with Scer\GAL4^nSyb.PS

embryonic/larval motor neuron | third instar larval stage, with Scer\GAL4^Toll-6-D42

atl^UAS.Tag:MYC

embryonic/larval neuromuscular junction | third instar larval stage

atl²

embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4^elav-C155

atl^dsRNA.UAS

embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4^nSyb.PS

embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4^Toll-6-D42

embryonic/larval somatic muscle, with Scer\GAL4^C57

atl^UAS.cLa

endoplasmic reticulum

atl¹

endoplasmic reticulum, with Scer\GAL4^Toll-6-D42

atl^UAS.Tag:MYC

endoplasmic reticulum, with Scer\GAL4^αTub84B.PL

atl^dsRNA.UAS

endoplasmic reticulum | larval stage, with Scer\GAL4²²¹

atl^HMS01627

endoplasmic reticulum | larval stage, with Scer\GAL4^Cg.PA

atl^GD242

endoplasmic reticulum | third instar larval stage

atl²

endoplasmic reticulum | third instar larval stage, with Scer\GAL4^nSyb.PS

endoplasmic reticulum | third instar larval stage, with Scer\GAL4^Toll-6-D42

atl^UAS.Tag:MYC

eye, with Scer\GAL4^ey.PH

atl^UAS.Tag:MYC

eye, with Scer\GAL4^GMR.PF

atl^UAS.Tag:MYC

imaginal disc | somatic clone

atl¹

larval dorsal multidendritic neuron ddaE | larval stage

atl²

larval dorsal multidendritic neuron ddaE | larval stage, with Scer\GAL4²²¹

lipid droplet | larval stage, with Scer\GAL4^Cg.PA

atl^GD242

microtubule & embryonic/larval somatic muscle, with Scer\GAL4^C57

microtubule & embryonic/larval somatic muscle (with Df(3R)Exel7357)

atl²

NMJ bouton

atl²

NMJ bouton, with Scer\GAL4^C57

atl^R192Q.UAS

NMJ bouton (with Df(3R)Exel7357)

atl²

NMJ bouton | third instar larval stage, with Scer\GAL4^elav-C155

atl^dsRNA.UAS

oocyte

atl¹

postsynaptic membrane (with Df(3R)Exel7357)

atl²

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v7.1)

Homo sapiens (Human) (11)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\ATL2

15 of 15

Yes

Hsap\ATL1

13 of 15

Yes

Hsap\ATL3

13 of 15

Yes

Hsap\RNF112

3 of 15

Yes

Hsap\GBP1

1 of 15

Yes

Hsap\GBP2

1 of 15

Yes

Hsap\GBP3

1 of 15

Yes

Hsap\GBP4

1 of 15

Yes

Hsap\GBP5

1 of 15

Yes

Hsap\GBP6

1 of 15

Yes

Hsap\GBP7

1 of 15

Yes

Model Organism Orthologs (via DIOPT v7.1)

Mus musculus (laboratory mouse) (14)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Atl2

15 of 15

Yes

Mmus\Atl3

13 of 15

Yes

Mmus\Atl1

12 of 15

Yes

Mmus\Rnf112

3 of 15

Yes

Mmus\Gbp2b

1 of 15

Yes

Mmus\Gbp2

1 of 15

Yes

Mmus\Gbp3

1 of 15

Yes

Mmus\Gbp4

1 of 15

Yes

Mmus\Gbp5

1 of 15

Yes

Mmus\Gbp6

1 of 15

Yes

Mmus\Gbp7

1 of 15

Yes

Mmus\Gbp8

1 of 15

Yes

Mmus\Gbp9

1 of 15

Yes

Mmus\Gbp10

1 of 15

Yes

Rattus norvegicus (Norway rat) (8)

Rnor\Atl3

11 of 13

Yes

Rnor\Atl1

10 of 13

Yes

Rnor\Atl2

10 of 13

Yes

Rnor\Rnf112

3 of 13

Yes

Rnor\Gbp2

1 of 13

Yes

Rnor\Gbp3

1 of 13

Yes

Rnor\Gbp4

1 of 13

Yes

Rnor\Gbp5

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (10)

Xtro\atl2

8 of 12

Yes

Xtro\atl1

7 of 12

Yes

Xtro\atl3

7 of 12

Yes

Xtro\rnf112.1

2 of 12

Yes

Xtro\rnf112

2 of 12

Yes

Xtro\gbp1

1 of 12

Yes

Xtro\gbp4

1 of 12

Yes

Xtro\gbp5

1 of 12

Yes

Xtro\gbp6

1 of 12

Yes

Xtro\gbp7

1 of 12

Yes

Danio rerio (Zebrafish) (11)

Drer\atl1

13 of 15

Yes

Drer\atl3

13 of 15

Yes

Drer\atl2

9 of 15

Yes

Drer\zgc:158270

3 of 15

Yes

Drer\gbp1

1 of 15

Yes

Drer\gbp2

1 of 15

Yes

Drer\gbp4

1 of 15

Yes

Drer\LOC100149641

1 of 15

Yes

Drer\LOC100535674

1 of 15

Yes

Drer\si:ch211-209n20.1

1 of 15

Yes

Drer\unm_sa911

1 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (3)

Cele\atln-1

13 of 15

Yes

Cele\atln-2

5 of 15

Yes

Cele\Y57E12B.1

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (1)

Atha\AT2G38840

2 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG0919058H )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Dmel\atl

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA19766

Drosophila persimilis

Dper\GL13613

Drosophila willistoni

Dwil\GK10964

Drosophila virilis

Dvir\GJ23644

Drosophila mojavensis

Dmoj\GI24013

Drosophila grimshawi

Dgri\GH18437

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091503I3 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17012767

Glossina morsitans

Tsetse fly

Gmor\GMOY001331

Glossina morsitans

Tsetse fly

Gmor\GMOY000862

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_06156

Mayetiola destructor

Hessian fly

Mdes\Mdes001008

Mayetiola destructor

Hessian fly

Mdes\Mdes007347

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL003109

Anopheles darlingi

American malaria mosquito

Adar\ADAC005699

Anopheles gambiae

Malaria mosquito

Agam\GPROR76

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ008647

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W058E )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA003598

Bombyx mori

Silkmoth

Bmor\BGIBMGA000802

Bombyx mori

Silkmoth

Bmor\BGIBMGA003573

Bombyx mori

Silkmoth

Bmor\BGIBMGA000767

Bombyx mori

Silkmoth

Bmor\BGIBMGA003574

Bombyx mori

Silkmoth

Bmor\BGIBMGA003575

Danaus plexippus

Monarch butterfly

Dple\DPOGS212821-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS212858-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL010112

Apis florea

Little honeybee

Aflo\2775702564

Apis mellifera

Western honey bee

Amel\GB44396

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP19300

Bombus terrestris

Buff-tailed bumblebee

Bter\15216684

Linepithema humile

Argentine ant

Lhum\LH18317

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:001c1b

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG006190

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_05443

Tribolium castaneum

Red flour beetle

Tcas\TC009975

Tribolium castaneum

Red flour beetle

Tcas\TC008712

Tribolium castaneum

Red flour beetle

Tcas\TC033188

Pediculus humanus

Human body louse

Phum\PHUM452510

Rhodnius prolixus

Kissing bug

Rpro\RPRC012231

Rhodnius prolixus

Kissing bug

Rpro\RPRC009957

Rhodnius prolixus

Kissing bug

Rpro\RPRC002118

Cimex lectularius

Bed bug

Clec\CLEC013238

Cimex lectularius

Bed bug

Clec\CLEC007207

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI002537

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI068591

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_10192

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_11785

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X03FH )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR003080

Ixodes scapularis

Black-legged tick

Isca\ISCW003306

Stegodyphus mimosarum

African social velvet spider

Smim\KFM64623.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM70854.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur10g04380

Tetranychus urticae

Two-spotted spider mite

Turt\tetur10g04370

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_303236

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G053P )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-AtlL1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Atl2

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Atl

Ciona intestinalis

Vase tunicate

Cint\LOC100183306

Gallus gallus

Domestic chicken

Ggal\ATL2

Gallus gallus

Domestic chicken

Ggal\ATL1

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v7.1)

Drosophila melanogaster (Fruit fly) (0)

No records found.

Human Disease Associations

FlyBase Human Disease Model Reports

spastic paraplegia 3A

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

atl^dsRNA.UAS

model of hereditary spastic paraplegia

CEA

(Summerville et al., 2016)

Potential Models Based on Orthology ( 3 )

Human Ortholog

Disease

Evidence

References

ATL1; atlastin GTPase 1

model of hereditary sensory neuropathy type 1D

IEA

(FlyBase, 2019-)

model of hereditary spastic paraplegia 3A

IEA

(FlyBase, 2019-)

ATL3; atlastin GTPase 3

model of hereditary sensory neuropathy type 1F

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ATL2; atlastin GTPase 2

15 of 15

609368

ATL1; atlastin GTPase 1

13 of 15

606439

ATL3; atlastin GTPase 3

13 of 15

609369

NEUROPATHY, HEREDITARY SENSORY, TYPE IF; HSN1F

hereditary sensory neuropathy type 1F

RNF112; ring finger protein 112

3 of 15

601237

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

atl

fluorescent resonance energy transfer, x-ray crystallography, anti tag coimmunoprecipitation, anti tag western blot, cross-linking study, enzymatic study, cosedimentation, molecular weight estimation by staining

(Liu et al., 2015, Wu et al., 2015, Saini et al., 2014, Bian et al., 2011, Moss et al., 2011, Orso et al., 2009)

atl - CG1105

experimental knowledge based

(Guruharsha et al., 2011)

atl - TER94

anti tag coimmunoprecipitation, western blot, peptide massfingerprinting

(O'Sullivan et al., 2013)

atl - spas

pull down, anti tag western blot

(Lee et al., 2009)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

atl

suppressible

Rtnl1

(Summerville et al., 2016)

suppressible

(Lee et al., 2009)

enhanceable

(O'Sullivan et al., 2013)

atl

suppressible

TER94

(O'Sullivan et al., 2013)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Rtnl1

suppressible

atl

(Summerville et al., 2016)

External Data

Subunit Structure (UniProtKB)

Homooligomer; trans-homooligomer between proteins on adjacent membranes. Interacts with spas; interaction may regulate microtubule dynamics.

(UniProt, Q9VC57 )

Linkouts

BioGRID - A database of protein and genetic interactions.

67860

DroID - A comprehensive database of gene and protein interactions.

FBgn0039213

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

42934

MIST (genetic) - An integrated Molecular Interaction Database

MIST (protein-protein) - An integrated Molecular Interaction Database

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-85

Cytogenetic map

96A13-96A13

Sequence location

3R:24,625,671..24,634,714 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

96A13-96A13

Limits computationally determined from genome sequence between P{PZ}crb⁰⁷²⁰⁷&P{PZ}BRWD3⁰⁵⁸⁴² and P{EP}CycB3^EP3127

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-85

(FlyBase, 2016)

3-84.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (14)

Bloomington

37303

y¹ w^*; Mi{MIC}atl^MI00863

17414

y¹ w^67c23; P{EPgy2}atl^EY07916

21236

y¹ w^67c23; P{EPgy2}atl^EY16768

25560

w¹¹¹⁸; Mi{ET1}atl^MB07599/TM6C, Sb¹

36736

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01627}attP40

Kyoto

125963

w¹¹¹⁸; P{RS5}atl^5-SZ-3256

113713

w^*; P{GawB}atl^NP5390 / TM6, P{UAS-lacZ.UW23-1}UW23-1

104083

w^*; P{GawB}atl^NP2088 / TM3, Sb¹ Ser¹

112990

w^*; P{GawB}atl^NP2644 / TM3, Sb¹ Ser¹

105010

y^* w^*; P{GawB}atl^NP5434 / TM6, P{UAS-lacZ.UW23-1}UW23-1

VDRC

v330341

P{VSH330341}attP40

v6719

w¹¹¹⁸; P{GD242}v6719

More stocks available...

Genomic Clones (20)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (269)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0039213

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0039213

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

42934

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Lee et al., 2009, Lee et al., 2008)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: atl CG6668

(Daga, 2004.2.23)

Source for database merge of

Additional comments

Other Comments

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 49 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

42934

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VC57

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

A0A0B4LHV8

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0039213

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0039213

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

atl_1
atl_2

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6668

Flygut - An atlas of the Drosophila adult midgut

FBgn0039213

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

42934

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG6668

modMine - A data warehouse for the modENCODE project

FBgn0039213

Linkouts

BioGRID - A database of protein and genetic interactions.

67860

DroID - A comprehensive database of gene and protein interactions.

FBgn0039213

DRSC - Results frm RNAi screens

FBgn0039213

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0039213

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG6668-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0039213

FlyMine - An integrated database for Drosophila genomics

FBgn0039213

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

42934

MIST (genetic) - An integrated Molecular Interaction Database

MIST (protein-protein) - An integrated Molecular Interaction Database

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

ATL

(Wu et al., 2015, Liu et al., 2012, Bian et al., 2011)

Atl

(Forgiarini et al., 2019, Saini et al., 2014)

CG6668

(Kolkhof et al., 2017, Meadows, 2017.1.11, Hosono et al., 2015, Krahmer et al., 2013, Cammarato et al., 2011, Ni et al., 2011.7.19, Lee et al., 2008, Manning, 2001.10.15)

atl

(Forgiarini et al., 2019, Bussmann and Storkebaum, 2017, De Gregorio et al., 2017, Xu et al., 2017, Summerville et al., 2016, Zhu et al., 2013, Moss et al., 2011, Lee et al., 2009, Orso et al., 2009, Tan et al., 2009, Lee et al., 2008)

dAtl

(Betancourt-Solis et al., 2018, Faust et al., 2015)

Name Synonyms

Atlastin

(Chen et al., 2015, Faust et al., 2015, Saini et al., 2014, Krahmer et al., 2013, Bayat et al., 2011)

D-atlastin

(Orso et al., 2008, Korey, 2007, Orso et al., 2007, Pantano et al., 2005, Gazziero et al., 2004)

atlastin

(Betancourt-Solis et al., 2018, Rao et al., 2016, Wu et al., 2015, Nakayama et al., 2014, O'Sullivan et al., 2013, Bian et al., 2011, Cammarato et al., 2011, Moss et al., 2011, Orso et al., 2009, Lee et al., 2008, Gazziero et al., 2004)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (70)

Report Sections

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