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Gene: Dmel\atl

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General Information
Symbol
Dmel\atl
Species
D. melanogaster
Name
atlastin
Annotation Symbol
CG6668
Feature Type
protein_coding_gene
FlyBase ID
FBgn0039213
Gene Model Status
Current
Stock Availability
14 publicly available
Gene Snapshot
atlastin (atl) encodes a dynamin-like membrane-bound GTPase that mediates endoplasmic reticulum membrane fusion in a GTP-dependent fashion. It is required for normal growth of muscles and synapses at the neuromuscular junction. [Date last reviewed: 2018-11-08]
Other Summaries
Key Links
Genomic Location
Cytogenetic map
96A13-96A13
Sequence location
3R:24,625,671..24,634,714 [+]
Recombination map
3-85
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI Genome Data Viewer
UCSC Genome Browser
Ensembl Genome Browser
PopFly Genome Browser
GO Summary Ribbons
Families, Domains and Molecular Function
Gene Group Membership (FlyBase)
Protein Family (UniProt, Sequence Similarities)
Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily. (Q9VC57)
Protein Domains/Motifs
InterPro
Guanylate-binding protein, N-terminal; P-loop containing nucleoside triphosphate hydrolase; GB1/RHD3-type guanine nucleotide-binding (G) domain; Guanylate-binding protein, C-terminal domain superfamily
Molecular Function (see GO section for details)
Experimental Evidence
GTP binding; GTPase activity; guanyl ribonucleotide binding; identical protein binding; protein binding; protein homodimerization activity
Predictions / Assertions
-
Summaries
UniProt Contributed Function Data
GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate microtubule polymerization and Golgi biogenesis. Required for dopaminergic neurons survival and the growth of muscles and synapses at neuromuscular junctions.
(UniProt, Q9VC57)
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\atl or the JBrowse view of Dmel\atl for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Gene model reviewed during 5.49
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.55
Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
atl-RA
FBtr0084656
NM_143017
2889
541
atl-RB
FBtr0084657
NM_170157
3207
541
atl-RC
FBtr0345218
NM_001300577
2907
541
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
atl-PA
FBpp0084036
60.9
541
6.51
NP_651274
AAF56318
atl-PB
FBpp0084037
60.9
541
6.51
NP_733020
AAN14008
atl-PC
FBpp0311413
60.9
541
6.51
NP_001287506
AHN57505
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

541 aa isoforms: atl-PA, atl-PB, atl-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)
Homooligomer; trans-homooligomer between proteins on adjacent membranes. Interacts with spas; interaction may regulate microtubule dynamics.
(UniProt, Q9VC57)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\atl using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (25 terms)
Molecular Function (6 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
GTP binding
inferred from mutant phenotype
(assigned by UniProt )
(Orso et al., 2009)
GTPase activity
inferred from direct assay
(Orso et al., 2009)
inferred from mutant phenotype
(Bian et al., 2011)
guanyl ribonucleotide binding
inferred from mutant phenotype
(Bian et al., 2011)
identical protein binding
inferred from direct assay
(assigned by UniProt )
(Orso et al., 2009)
protein binding
inferred from physical interaction with UniProtKB:Q8I0P1
(assigned by UniProt )
(Lee et al., 2009)
protein homodimerization activity
inferred from mutant phenotype
(Bian et al., 2011)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (12 terms)
Terms Based on Experimental Evidence (12 terms)
CV Term
Evidence
References
endoplasmic reticulum membrane fusion
inferred from direct assay
(Orso et al., 2009)
inferred from mutant phenotype
(Orso et al., 2009)
endoplasmic reticulum organization
inferred from mutant phenotype
(assigned by UniProt )
(Lee et al., 2009, Orso et al., 2009)
inferred from mutant phenotype
(Summerville et al., 2016)
Golgi organization
inferred from mutant phenotype
(assigned by UniProt )
(Lee et al., 2009)
membrane fusion
inferred from direct assay
(Bian et al., 2011)
inferred from direct assay
(assigned by UniProt )
(Orso et al., 2009)
microtubule depolymerization
inferred from mutant phenotype
(assigned by UniProt )
(Lee et al., 2009)
muscle organ development
inferred from mutant phenotype
(assigned by UniProt )
(Lee et al., 2009)
neuromuscular junction development
inferred from mutant phenotype
(Lee et al., 2009)
positive regulation of axon extension involved in regeneration
inferred from mutant phenotype
(Rao et al., 2016)
protein homooligomerization
inferred from direct assay
(assigned by UniProt )
(Orso et al., 2009)
regulation of microtubule depolymerization
inferred from mutant phenotype
(Lee et al., 2009)
regulation of synaptic growth at neuromuscular junction
inferred from mutant phenotype
(Lee et al., 2009)
synaptic growth at neuromuscular junction
inferred from mutant phenotype
(assigned by UniProt )
(Lee et al., 2009)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (7 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
cytoplasm
inferred from direct assay
(Lee et al., 2008)
endomembrane system
inferred from high throughput direct assay
(Tan et al., 2009)
endoplasmic reticulum
inferred from direct assay
(assigned by UniProt )
(Orso et al., 2009)
inferred from direct assay
(Lee et al., 2009)
Golgi apparatus
inferred from direct assay
(Lee et al., 2009)
intrinsic component of endoplasmic reticulum membrane
inferred from direct assay
(Orso et al., 2009)
membrane
inferred from direct assay
(assigned by UniProt )
(Orso et al., 2009)
colocalizes_with microtubule
inferred from direct assay
(assigned by UniProt )
(Lee et al., 2009)
Terms Based on Predictions or Assertions (0 terms)
Expression Data
Transcript Expression
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
embryonic/larval brain
(Lee et al., 2008)
ventral nerve cord
(Lee et al., 2008)
embryonic/larval somatic muscle
(Lee et al., 2008)
adult stage
adult brain | ubiquitous
(Lee et al., 2008)
dopaminergic neuron | subset of adult brain
(Lee et al., 2008)
oogenesis stage S5 -- S6
nurse cell
(Lee et al., 2008)
nurse cell
(Lee et al., 2008)
egg chamber | posterior
(Lee et al., 2008)
oogenesis stage S9
oocyte
(Lee et al., 2008)
oogenesis stage S10
follicle cell
(Lee et al., 2008)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
In early oogenesis, atl protein is expressed in the posterior compartment of the egg chamber and in the membrane and cytoplasm of nurse cells. At oogenesis stage 9 it is found in the anterior cytoplasm of the oocyte. It then disapeears from this domain and at stage 10 atl protein is strongly expressed in follicle cells. In the adult brain it is expressed ubiquitously, with some cellls, including a subset of dopaminergic neurons expressing atl strongly.
(Lee et al., 2008)
atl is detected in neuropil regions of the brain and ventral nerve cord of third instar larvae. It is also detected in motor axon bundles emanating from the ventral ganglia. It is highly expressed throughout the cytolasm of body wall muscles and present at lower levels in the proximal parts of presynaptic arbors. It is not present in synaptic boutons.
(Lee et al., 2008)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
cytoplasm
inferred from direct assay
(Lee et al., 2008)
endomembrane system
inferred from high throughput direct assay
(Tan et al., 2009)
endoplasmic reticulum
inferred from direct assay
(assigned by UniProt )
(Orso et al., 2009)
inferred from direct assay
(Lee et al., 2009)
Golgi apparatus
inferred from direct assay
(Lee et al., 2009)
intrinsic component of endoplasmic reticulum membrane
inferred from direct assay
(Orso et al., 2009)
membrane
inferred from direct assay
(assigned by UniProt )
(Orso et al., 2009)
colocalizes_with microtubule
inferred from direct assay
(assigned by UniProt )
(Lee et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\atl in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs and Phenotypes
Classical and Insertion Alleles ( 16 )
Transgenic Constructs ( 10 )
Deletions and Duplications ( 1 )
Summary of Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
lethal, with Scer\GAL4GMR.PF
lethal, with Scer\GAL4ple.PF
lethal, with Scer\GAL4pnr-MD237
lethal, with Scer\GAL4unspecified
lethal | pupal stage, with Scer\GAL4pnr-MD237
lethal - all die before end of pupal stage (with Df(3R)Exel7357)
lethal - all die before end of pupal stage | recessive
lethal - all die during embryonic stage, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
lethal - all die during larval stage, with Scer\GAL4Mef2.PR
viable
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
fertile
sterile | recessive
Other Phenotypes
Allele
bang sensitive
bang sensitive, with Scer\GAL4ple.PF
locomotor behavior defective
locomotor behavior defective | adult stage | progressive, with Scer\GAL4elav-C155
neuroanatomy defective | larval stage
neuroanatomy defective | larval stage, with Scer\GAL4C57
neuroanatomy defective | larval stage (with Df(3R)Exel7357)
neuroanatomy defective | third instar larval stage
neuroanatomy defective | third instar larval stage, with Scer\GAL4elav-C155
neuroanatomy defective | third instar larval stage, with Scer\GAL4nSyb.PS
neuroanatomy defective | third instar larval stage, with Scer\GAL4Toll-6-D42
neurophysiology defective | third instar larval stage
neurophysiology defective | third instar larval stage, with Scer\GAL4elav-C155
neurophysiology defective | third instar larval stage, with Scer\GAL4nSyb.PS
neurophysiology defective | third instar larval stage, with Scer\GAL4Toll-6-D42
short lived
size defective | adult stage, with Scer\GAL4GMR.PF
size defective | dominant | larval stage
size defective | larval stage, with Scer\GAL4221
small body | adult stage
small body | larval stage (with Df(3R)Exel7357)
small body | pupal stage
small body | recessive
some die during pupal stage (with Df(3R)Exel7357)
some die during pupal stage | recessive
visible | adult stage, with Scer\GAL4ey.PH
visible | adult stage, with Scer\GAL4GMR.PF
wound healing defective | dominant | larval stage
wound healing defective | larval stage, with Scer\GAL4221
Phenotype manifest in
Allele
abdominal 2 ventral longitudinal muscle 3 (with Df(3R)Exel7357)
abdominal 2 ventral longitudinal muscle 4 (with Df(3R)Exel7357)
axon | larval stage
axon | larval stage, with Scer\GAL4221
dopaminergic neuron
dopaminergic neuron, with Scer\GAL4ple.PF
dorsal multidendritic neuron ddaE | larval stage
dorsal multidendritic neuron ddaE | larval stage, with Scer\GAL4221
embryonic/larval motor neuron | third instar larval stage
embryonic/larval motor neuron | third instar larval stage, with Scer\GAL4nSyb.PS
embryonic/larval motor neuron | third instar larval stage, with Scer\GAL4Toll-6-D42
embryonic/larval neuromuscular junction | third instar larval stage
embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4elav-C155
embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4nSyb.PS
embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4Toll-6-D42
embryonic/larval somatic muscle, with Scer\GAL4C57
endoplasmic reticulum
endoplasmic reticulum, with Scer\GAL4Toll-6-D42
endoplasmic reticulum, with Scer\GAL4αTub84B.PL
endoplasmic reticulum | larval stage, with Scer\GAL4221
endoplasmic reticulum | third instar larval stage
endoplasmic reticulum | third instar larval stage, with Scer\GAL4nSyb.PS
endoplasmic reticulum | third instar larval stage, with Scer\GAL4Toll-6-D42
eye, with Scer\GAL4ey.PH
eye, with Scer\GAL4GMR.PF
imaginal disc | somatic clone
microtubule & embryonic/larval somatic muscle, with Scer\GAL4C57
microtubule & embryonic/larval somatic muscle (with Df(3R)Exel7357)
NMJ bouton
NMJ bouton, with Scer\GAL4C57
NMJ bouton (with Df(3R)Exel7357)
NMJ bouton | third instar larval stage, with Scer\GAL4elav-C155
oocyte
postsynaptic membrane (with Df(3R)Exel7357)
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (11)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ATL2
15 of 15
Yes
Yes
Hsap\ATL1
13 of 15
No
Yes
Hsap\ATL3
13 of 15
No
Yes
Hsap\RNF112
3 of 15
No
Yes
Hsap\GBP1
1 of 15
No
Yes
Hsap\GBP2
1 of 15
No
Yes
Hsap\GBP3
1 of 15
No
Yes
Hsap\GBP4
1 of 15
No
Yes
Hsap\GBP5
1 of 15
No
Yes
Hsap\GBP6
1 of 15
No
Yes
Hsap\GBP7
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (14)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Atl2
15 of 15
Yes
Yes
Mmus\Atl3
13 of 15
No
Yes
Mmus\Atl1
12 of 15
No
Yes
Mmus\Rnf112
3 of 15
No
Yes
Mmus\Gbp2b
1 of 15
No
Yes
Mmus\Gbp2
1 of 15
No
Yes
Mmus\Gbp3
1 of 15
No
Yes
Mmus\Gbp4
1 of 15
No
Yes
Mmus\Gbp5
1 of 15
No
Yes
Mmus\Gbp6
1 of 15
No
Yes
Mmus\Gbp7
1 of 15
No
Yes
Mmus\Gbp8
1 of 15
No
Yes
Mmus\Gbp9
1 of 15
No
Yes
Mmus\Gbp10
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (8)
Rnor\Atl3
11 of 13
Yes
Yes
Rnor\Atl1
10 of 13
No
Yes
Rnor\Atl2
10 of 13
No
Yes
Rnor\Rnf112
3 of 13
No
Yes
Rnor\Gbp2
1 of 13
No
Yes
Rnor\Gbp3
1 of 13
No
Yes
Rnor\Gbp4
1 of 13
No
Yes
Rnor\Gbp5
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (10)
Xtro\atl2
8 of 12
Yes
Yes
Xtro\atl1
7 of 12
No
Yes
Xtro\atl3
7 of 12
No
Yes
Xtro\rnf112.1
2 of 12
No
Yes
Xtro\rnf112
2 of 12
No
Yes
Xtro\gbp1
1 of 12
No
Yes
Xtro\gbp4
1 of 12
No
Yes
Xtro\gbp5
1 of 12
No
Yes
Xtro\gbp6
1 of 12
No
Yes
Xtro\gbp7
1 of 12
No
Yes
Danio rerio (Zebrafish) (11)
Drer\atl1
13 of 15
Yes
Yes
Drer\atl3
13 of 15
Yes
Yes
Drer\atl2
9 of 15
No
Yes
Drer\zgc:158270
3 of 15
No
Yes
Drer\gbp1
1 of 15
No
Yes
Drer\gbp2
1 of 15
No
Yes
Drer\gbp4
1 of 15
No
Yes
Drer\LOC100149641
1 of 15
No
Yes
Drer\LOC100535674
1 of 15
No
Yes
Drer\si:ch211-209n20.1
1 of 15
No
Yes
Drer\unm_sa911
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (3)
Cele\atln-1
13 of 15
Yes
Yes
Cele\atln-2
5 of 15
No
Yes
Cele\Y57E12B.1
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (1)
Atha\AT2G38840
2 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
No orthologs reported.
Schizosaccharomyces pombe (Fission yeast) (0)
No orthologs reported.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG0919058H )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\atl
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00008731
Drosophila simulans
Dsim\GD21113
Drosophila sechellia
Dsec\GM26614
Drosophila erecta
Dere\GG11305
Drosophila yakuba
Dyak\GE23502
Drosophila ananassae
Dana\GF17217
Drosophila pseudoobscura pseudoobscura
Dpse\GA19766
Drosophila persimilis
Dper\GL13613
Drosophila willistoni
Dwil\GK10964
Drosophila virilis
Dvir\GJ23644
Drosophila mojavensis
Dmoj\GI24013
Drosophila grimshawi
Dgri\GH18437
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091503I3 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17012767
Glossina morsitans
Tsetse fly
Gmor\GMOY001331
Glossina morsitans
Tsetse fly
Gmor\GMOY000862
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_06156
Mayetiola destructor
Hessian fly
Mdes\Mdes001008
Mayetiola destructor
Hessian fly
Mdes\Mdes007347
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL003109
Anopheles darlingi
American malaria mosquito
Adar\ADAC005699
Anopheles gambiae
Malaria mosquito
Agam\GPROR76
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ008647
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W058E )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA003598
Bombyx mori
Silkmoth
Bmor\BGIBMGA000802
Bombyx mori
Silkmoth
Bmor\BGIBMGA003573
Bombyx mori
Silkmoth
Bmor\BGIBMGA000767
Bombyx mori
Silkmoth
Bmor\BGIBMGA003574
Bombyx mori
Silkmoth
Bmor\BGIBMGA003575
Danaus plexippus
Monarch butterfly
Dple\DPOGS212821-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS212858-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL010112
Apis florea
Little honeybee
Aflo\2775702564
Apis mellifera
Western honey bee
Amel\GB44396
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP19300
Bombus terrestris
Buff-tailed bumblebee
Bter\15216684
Linepithema humile
Argentine ant
Lhum\LH18317
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001c1b
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG006190
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_05443
Tribolium castaneum
Red flour beetle
Tcas\TC009975
Tribolium castaneum
Red flour beetle
Tcas\TC008712
Tribolium castaneum
Red flour beetle
Tcas\TC033188
Pediculus humanus
Human body louse
Phum\PHUM452510
Rhodnius prolixus
Kissing bug
Rpro\RPRC012231
Rhodnius prolixus
Kissing bug
Rpro\RPRC009957
Rhodnius prolixus
Kissing bug
Rpro\RPRC002118
Cimex lectularius
Bed bug
Clec\CLEC013238
Cimex lectularius
Bed bug
Clec\CLEC007207
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI002537
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI068591
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_10192
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_11785
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X03FH )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR003080
Ixodes scapularis
Black-legged tick
Isca\ISCW003306
Stegodyphus mimosarum
African social velvet spider
Smim\KFM64623.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM70854.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur10g04380
Tetranychus urticae
Two-spotted spider mite
Turt\tetur10g04370
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_303236
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G053P )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-AtlL1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Atl2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Atl
Ciona intestinalis
Vase tunicate
Cint\LOC100183306
Gallus gallus
Domestic chicken
Ggal\ATL2
Gallus gallus
Domestic chicken
Ggal\ATL1
Human Disease Model Data
FlyBase Human Disease Model Reports
Alleles Reported to Model Human Disease (Disease Ontology)
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Models ( 1 )
Allele
Disease
Evidence
References
atldsRNA.UAS
model of  hereditary spastic paraplegia
inferred from mutant phenotype
(Summerville et al., 2016)
Interactions ( 0 )
Allele
Disease
Interaction
References
Comments ( 0 )
 
Human Orthologs (via DIOPT v7.1)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
Complementation?
Transgene?
ATL2; atlastin GTPase 2
15 of 15
609368
    ATL1; atlastin GTPase 1
    13 of 15
    606439
    ATL3; atlastin GTPase 3
    13 of 15
    609369
    RNF112; ring finger protein 112
    3 of 15
    601237
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      Summary of Genetic Interactions
      esyN Network Diagram
      esyN Network Key:
      Suppression
      Enhancement
      View in Interactions Browser
      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      atl
      suppressible
      Rtnl1
      (Summerville et al., 2016)
      atl
      suppressible
      spas
      (Lee et al., 2009)
      atl
      suppressible
      TER94
      (O'Sullivan et al., 2013)
      atl
      enhanceable
      TER94
      (O'Sullivan et al., 2013)
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Rtnl1
      suppressible
      atl
      (Summerville et al., 2016)
      External Data
      Subunit Structure (UniProtKB)
      Homooligomer; trans-homooligomer between proteins on adjacent membranes. Interacts with spas; interaction may regulate microtubule dynamics.
      (UniProt, Q9VC57 )
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      Pathways
      Gene Group - Pathway Membership (FlyBase)
      External Data
      Linkouts
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      3R
      Recombination map
      3-85
      Cytogenetic map
      96A13-96A13
      Sequence location
      3R:24,625,671..24,634,714 [+]
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      96A13-96A13
      Limits computationally determined from genome sequence between P{PZ}crb07207&P{PZ}BRWD305842 and P{EP}CycB3EP3127
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      Experimentally Determined Recombination Data
      Location
      3-85
      (FlyBase, 2016)
      3-84.1
      (Comeron et al., 2012)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (14)
      Genomic Clones (20)
      cDNA Clones (269)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequences
      BDGP DGC clones
      Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         
        polyclonal
        (Lee et al., 2009, Lee et al., 2008)
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of
        Source for identity of: atl CG6668
        (Daga, 2004.2.23)
        Source for database merge of
        Additional comments
        Other Comments
        Origin and Etymology
        Discoverer
        Etymology
        Identification
        External Crossreferences and Linkouts ( 46 )
        Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        InterPro - A database of protein families, domains and functional sites
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center cDNA clones
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        FlyMine - An integrated database for Drosophila genomics
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        KEGG Genes - Molecular building blocks of life in the genomic space.
        modMine - A data warehouse for the modENCODE project
        Synonyms and Secondary IDs (8)
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        References (66)