FB2022_03, released June 9, 2022

Gene: Dmel\atl

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General Information
Symbol
Dmel\atl
Species
D. melanogaster
Name
atlastin
Annotation Symbol
CG6668
Feature Type
protein_coding_gene
FlyBase ID
FBgn0039213
Gene Model Status
Current
Stock Availability
21 publicly available
Gene Summary
atlastin (atl) encodes a dynamin-like membrane-bound GTPase that mediates endoplasmic reticulum membrane fusion in a GTP-dependent fashion. It is required for normal growth of muscles and synapses at the neuromuscular junction. [Date last reviewed: 2018-11-08] (FlyBase Gene Snapshot)
All Summaries
Also Known As

D-atlastin, dAtl

Key Links
Genomic Location
Cytogenetic map
96A13-96A13
Sequence location
Recombination map
3-85
RefSeq locus
NT_033777 REGION:24625671..24634714
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (24 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
enables GTP binding
inferred from mutant phenotype
(assigned by UniProt )
(Orso et al., 2009)
enables GTPase activity
inferred from mutant phenotype
(Bian et al., 2011)
inferred from direct assay
(Orso et al., 2009)
enables guanyl ribonucleotide binding
inferred from mutant phenotype
(Bian et al., 2011)
enables identical protein binding
inferred from direct assay
(assigned by UniProt )
(Orso et al., 2009)
enables protein binding
inferred from physical interaction with UniProtKB:Q8I0P1
(assigned by UniProt )
(Lee et al., 2009)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables GTP binding
inferred from biological aspect of ancestor with PANTHER:PTN000079086
(assigned by GO_Central )
(Gaudet et al., 2011)
enables GTPase activity
inferred from biological aspect of ancestor with PANTHER:PTN000079086
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (12 terms)
Terms Based on Experimental Evidence (12 terms)
CV Term
Evidence
References
involved_in endoplasmic reticulum membrane fusion
inferred from direct assay
(Orso et al., 2009)
inferred from mutant phenotype
(Orso et al., 2009)
involved_in endoplasmic reticulum organization
inferred from mutant phenotype
(Summerville et al., 2016)
inferred from mutant phenotype
(assigned by UniProt )
(Lee et al., 2009, Orso et al., 2009)
involved_in Golgi organization
inferred from mutant phenotype
(assigned by UniProt )
(Lee et al., 2009)
involved_in membrane fusion
inferred from direct assay
(Klemm et al., 2013, Bian et al., 2011)
inferred from direct assay
(assigned by UniProt )
(Orso et al., 2009)
involved_in microtubule depolymerization
inferred from mutant phenotype
(assigned by UniProt )
(Lee et al., 2009)
involved_in muscle organ development
inferred from mutant phenotype
(assigned by UniProt )
(Lee et al., 2009)
involved_in neuromuscular junction development
inferred from mutant phenotype
(Lee et al., 2009)
involved_in positive regulation of axon extension involved in regeneration
inferred from mutant phenotype
(Rao et al., 2016)
involved_in protein homooligomerization
inferred from direct assay
(assigned by UniProt )
(Orso et al., 2009)
involved_in regulation of microtubule depolymerization
inferred from mutant phenotype
(Lee et al., 2009)
involved_in regulation of synaptic assembly at neuromuscular junction
inferred from mutant phenotype
(Lee et al., 2009)
involved_in synaptic assembly at neuromuscular junction
inferred from mutant phenotype
(assigned by UniProt )
(Lee et al., 2009)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in endoplasmic reticulum organization
inferred from biological aspect of ancestor with PANTHER:PTN000844237
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in protein homooligomerization
inferred from biological aspect of ancestor with PANTHER:PTN000844237
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (7 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Lee et al., 2008)
located_in endomembrane system
inferred from high throughput direct assay
(Tan et al., 2009)
located_in endoplasmic reticulum
inferred from direct assay
(assigned by UniProt )
(Orso et al., 2009)
inferred from direct assay
(Lee et al., 2009)
located_in Golgi apparatus
inferred from direct assay
(Lee et al., 2009)
located_in intrinsic component of endoplasmic reticulum membrane
inferred from direct assay
(Orso et al., 2009)
located_in membrane
inferred from direct assay
(assigned by UniProt )
(Orso et al., 2009)
colocalizes_with microtubule
inferred from direct assay
(assigned by UniProt )
(Lee et al., 2009)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. GB1 subfamily. (Q9VC57)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
atlastin (atl) encodes a dynamin-like membrane-bound GTPase that mediates endoplasmic reticulum membrane fusion in a GTP-dependent fashion. It is required for normal growth of muscles and synapses at the neuromuscular junction. [Date last reviewed: 2018-11-08]
Gene Group (FlyBase)
OTHER GTPASES -
Other GTPases are a collection of GTPases that do not fall into any major GTPase groups.
Protein Function (UniProtKB)
GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate microtubule polymerization and Golgi biogenesis. Required for dopaminergic neurons survival and the growth of muscles and synapses at neuromuscular junctions.
(UniProt, Q9VC57)
Summary (Interactive Fly)
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\atl for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure New Section
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VC57)

If you don't see the viewer to the right, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Gene model reviewed during 5.49

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
atl-RA
FBtr0084656
NM_143017
2889
541
atl-RB
FBtr0084657
NM_170157
3207
541
atl-RC
FBtr0345218
NM_001300577
2907
541
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
atl-PA
FBpp0084036
60.9
541
6.51
Q9VC57
NP_651274
AAF56318
atl-PB
FBpp0084037
60.9
541
6.51
Q9VC57
NP_733020
AAN14008
atl-PC
FBpp0311413
60.9
541
6.51
Q9VC57
NP_001287506
AHN57505
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

541 aa isoforms: atl-PA, atl-PB, atl-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Homooligomer; trans-homooligomer between proteins on adjacent membranes. Interacts with spas; interaction may regulate microtubule dynamics.

(UniProt, Q9VC57)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\atl using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that the Fly Cell Atlas project found the gene expressed in that cell type. Darker colors mean that more cells of that cell type express the gene:
 low
high 
Colorless tiles indicate that there is no scRNAseq data for the gene in that cell type.
Colored tiles in ribbon indicate that expression data (RNA and/or protein) has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
Colored tiles in the ribbon indicate the average RNA expression level of the gene at the indicated stages:
 low
high 
as determined by RNA-seq (RPKM) using whole organism samples modENCODE, Brown et al., 2014. For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
embryonic/larval brain
(Lee et al., 2008)
larval ventral nerve cord
(Lee et al., 2008)
embryonic/larval somatic muscle cell
(Lee et al., 2008)
adult stage
adult brain | ubiquitous
(Lee et al., 2008)
dopaminergic neuron | subset of adult brain
(Lee et al., 2008)
oogenesis stage S5 -- S6
nurse cell
(Lee et al., 2008)
nurse cell
(Lee et al., 2008)
egg chamber | posterior
(Lee et al., 2008)
oogenesis stage S9
oocyte
(Lee et al., 2008)
oogenesis stage S10
follicle cell
(Lee et al., 2008)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data

atl is detected in neuropil regions of the brain and ventral nerve cord of third instar larvae. It is also detected in motor axon bundles emanating from the ventral ganglia. It is highly expressed throughout the cytolasm of body wall muscles and present at lower levels in the proximal parts of presynaptic arbors. It is not present in synaptic boutons.

(Lee et al., 2008)

In early oogenesis, atl protein is expressed in the posterior compartment of the egg chamber and in the membrane and cytoplasm of nurse cells. At oogenesis stage 9 it is found in the anterior cytoplasm of the oocyte. It then disapeears from this domain and at stage 10 atl protein is strongly expressed in follicle cells. In the adult brain it is expressed ubiquitously, with some cellls, including a subset of dopaminergic neurons expressing atl strongly.

(Lee et al., 2008)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Lee et al., 2008)
located_in endomembrane system
inferred from high throughput direct assay
(Tan et al., 2009)
located_in endoplasmic reticulum
inferred from direct assay
(assigned by UniProt )
(Orso et al., 2009)
inferred from direct assay
(Lee et al., 2009)
located_in Golgi apparatus
inferred from direct assay
(Lee et al., 2009)
located_in intrinsic component of endoplasmic reticulum membrane
inferred from direct assay
(Orso et al., 2009)
located_in membrane
inferred from direct assay
(assigned by UniProt )
(Orso et al., 2009)
colocalizes_with microtubule
inferred from direct assay
(assigned by UniProt )
(Lee et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\atl in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 20 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 15 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of atl
Transgenic constructs containing regulatory region of atl
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(3R)Exel7357
(Lee et al., 2009, Ryder, 2004.4.26)
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
lethal, with Scer\GAL4GMR.PF
lethal, with Scer\GAL4ple.PF
lethal, with Scer\GAL4pnr-MD237
lethal, with Scer\GAL4unspecified
lethal | pupal stage, with Scer\GAL4pnr-MD237
lethal - all die before end of pupal stage (with Df(3R)Exel7357)
lethal - all die before end of pupal stage | recessive
lethal - all die during embryonic stage
lethal - all die during embryonic stage, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
lethal - all die during larval stage, with Scer\GAL4Mef2.PR
partially lethal - majority die | recessive
partially lethal - majority live | recessive
viable
viable, with Scer\GAL4GMR.PU
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
fertile
sterile | recessive
Other Phenotypes
Allele
abnormal locomotor behavior
abnormal locomotor behavior | adult stage (with atlEY07916)
abnormal locomotor behavior | adult stage (with atlMB07599)
abnormal locomotor behavior | adult stage | progressive, with Scer\GAL4elav-C155
abnormal neuroanatomy | larval stage
abnormal neuroanatomy | larval stage, with Scer\GAL4C57
abnormal neuroanatomy | larval stage (with Df(3R)Exel7357)
abnormal neuroanatomy | third instar larval stage
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4elav-C155
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4nSyb.PS
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4Toll-6-D42
abnormal neurophysiology | third instar larval stage
abnormal neurophysiology | third instar larval stage, with Scer\GAL4elav-C155
abnormal neurophysiology | third instar larval stage, with Scer\GAL4nSyb.PS
abnormal neurophysiology | third instar larval stage, with Scer\GAL4Toll-6-D42
abnormal size | adult stage, with Scer\GAL4GMR.PF
abnormal size | dominant | larval stage
abnormal size | larval stage, with Scer\GAL4221
abnormal size | larval stage, with Scer\GAL4Cg.PA
abnormal starvation stress response | adult stage, with Scer\GAL4Cg.PA
abnormal wound healing | dominant | larval stage
abnormal wound healing | larval stage, with Scer\GAL4221
bang sensitive
bang sensitive, with Scer\GAL4ple.PF
decreased body size | adult stage
decreased body size | larval stage (with Df(3R)Exel7357)
decreased body size | P-stage
decreased body size | pupal stage
decreased body size | recessive
increased mortality | adult stage | calorie restriction conditional, with Scer\GAL4Cg.PA
short lived
some die during pupal stage (with Df(3R)Exel7357)
some die during pupal stage | recessive
visible | adult stage, with Scer\GAL4ey.PH
visible | adult stage, with Scer\GAL4GMR.PF
visible | adult stage, with Scer\GAL4GMR.PU
Phenotype manifest in
Allele
autophagosome | third instar larval stage
axon | larval stage
axon | larval stage, with Scer\GAL4221
dopaminergic neuron
dopaminergic neuron, with Scer\GAL4ple.PF
embryonic/larval brain | third instar larval stage
embryonic/larval brain | third instar larval stage, with Scer\GAL4Toll-6-D42
embryonic/larval fat body | larval stage, with Scer\GAL4Cg.PA
embryonic/larval motor neuron | third instar larval stage
embryonic/larval motor neuron | third instar larval stage, with Scer\GAL4nSyb.PS
embryonic/larval motor neuron | third instar larval stage, with Scer\GAL4Toll-6-D42
embryonic/larval neuromuscular junction | third instar larval stage
embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4elav-C155
embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4nSyb.PS
embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4Toll-6-D42
embryonic/larval somatic muscle cell, with Scer\GAL4C57
endoplasmic reticulum
endoplasmic reticulum, with Scer\GAL4Toll-6-D42
endoplasmic reticulum, with Scer\GAL4αTub84B.PL
endoplasmic reticulum | larval stage, with Scer\GAL4221
endoplasmic reticulum | larval stage, with Scer\GAL4Cg.PA
endoplasmic reticulum | third instar larval stage
endoplasmic reticulum | third instar larval stage, with Scer\GAL4nSyb.PS
endoplasmic reticulum | third instar larval stage, with Scer\GAL4Toll-6-D42
endoplasmic reticulum membrane | third instar larval stage, with Scer\GAL4Toll-6-D42
eye, with Scer\GAL4ey.PH
eye, with Scer\GAL4GMR.PF
eye, with Scer\GAL4GMR.PU
Golgi stack | third instar larval stage
imaginal disc | somatic clone
larval dorsal multidendritic neuron ddaE | larval stage
larval dorsal multidendritic neuron ddaE | larval stage, with Scer\GAL4221
larval ventral nerve cord | third instar larval stage
lipid droplet | larval stage, with Scer\GAL4Cg.PA
microtubule & embryonic/larval somatic muscle, with Scer\GAL4C57
microtubule & embryonic/larval somatic muscle (with Df(3R)Exel7357)
muscle cell of abdominal 2 ventral longitudinal muscle 3 (with Df(3R)Exel7357)
muscle cell of abdominal 2 ventral longitudinal muscle 4 (with Df(3R)Exel7357)
NMJ bouton
NMJ bouton, with Scer\GAL4C57
NMJ bouton (with Df(3R)Exel7357)
NMJ bouton | third instar larval stage, with Scer\GAL4elav-C155
oocyte
postsynaptic membrane (with Df(3R)Exel7357)
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (12)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ATL2
15 of 15
Yes
Yes
Hsap\ATL1
13 of 15
No
Yes
Hsap\ATL3
12 of 15
No
Yes
Hsap\GBP2
3 of 15
No
Yes
Hsap\GBP3
3 of 15
No
Yes
Hsap\GBP4
3 of 15
No
Yes
Hsap\GBP5
3 of 15
No
Yes
Hsap\GBP6
3 of 15
No
Yes
Hsap\GBP7
3 of 15
No
Yes
Hsap\RNF112
3 of 15
No
Yes
Hsap\GBP1
2 of 15
No
Yes
Hsap\SRD5A2
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (15)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Atl2
15 of 15
Yes
Yes
Mmus\Atl1
13 of 15
No
Yes
Mmus\Atl3
12 of 15
No
Yes
Mmus\Gbp2
3 of 15
No
Yes
Mmus\Gbp3
3 of 15
No
Yes
Mmus\Gbp4
3 of 15
No
Yes
Mmus\Gbp6
3 of 15
No
Yes
Mmus\Gbp8
3 of 15
No
Yes
Mmus\Gbp9
3 of 15
No
Yes
Mmus\Rnf112
3 of 15
No
Yes
Mmus\Gbp2b
2 of 15
No
Yes
Mmus\Gbp5
2 of 15
No
Yes
Mmus\Gbp7
2 of 15
No
Yes
Mmus\Gbp10
2 of 15
No
Yes
Mmus\Gbp11
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (17)
Rnor\Atl2
11 of 13
Yes
Yes
Rnor\Atl1
10 of 13
No
Yes
Rnor\Atl3
10 of 13
No
Yes
Rnor\Gbp2
3 of 13
No
Yes
Rnor\Gbp3
3 of 13
No
Yes
Rnor\Gbp4
3 of 13
No
Yes
Rnor\Gbp5
3 of 13
No
Yes
Rnor\Rnf112
3 of 13
No
Yes
Rnor\Gbp6
2 of 13
No
Yes
Rnor\Gbp1
1 of 13
No
Yes
Rnor\LOC685067
1 of 13
No
Yes
Rnor\LOC687532
1 of 13
No
Yes
Rnor\LOC100359633
1 of 13
No
Yes
Rnor\LOC100911495
1 of 13
No
Yes
Rnor\LOC102554096
1 of 13
No
Yes
Rnor\LOC102554737
1 of 13
No
Yes
Rnor\RGD1560801
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (13)
Xtro\atl2
9 of 12
Yes
Yes
Xtro\atl1
8 of 12
No
Yes
Xtro\atl3
7 of 12
No
Yes
Xtro\gbp1
3 of 12
No
Yes
Xtro\gbp5
3 of 12
No
Yes
Xtro\gbp6
3 of 12
No
Yes
Xtro\gbp7
3 of 12
No
Yes
Xtro\rnf112.1
3 of 12
No
Yes
Xtro\rnf112
3 of 12
No
Yes
Xtro\gbp4
2 of 12
No
Yes
Xtro\gbp2
1 of 12
No
Yes
Xtro\LOC100488013
1 of 12
No
Yes
Xtro\LOC100496673
1 of 12
No
Yes
Danio rerio (Zebrafish) (13)
Drer\atl1
13 of 15
Yes
Yes
Drer\atl3
12 of 15
No
Yes
Drer\atl2
9 of 15
No
Yes
Drer\gbp1
3 of 15
No
Yes
Drer\gbp2
3 of 15
No
Yes
Drer\gbp4
3 of 15
No
Yes
Drer\LOC100535674
3 of 15
No
Yes
Drer\si:ch211-209n20.1
3 of 15
No
Yes
Drer\si:dkeyp-30d6.2
3 of 15
No
Yes
Drer\unm_sa911
3 of 15
No
Yes
Drer\zgc:158270
3 of 15
No
Yes
Drer\gbp3
1 of 15
No
Yes
Drer\LOC100334716
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\atln-1
13 of 15
Yes
Yes
Cele\atln-2
4 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (3)
Atha\AT2G38840
3 of 9
Yes
Yes
Atha\AT5G46070
2 of 9
No
Yes
Atha\AT1G03830
1 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Other Organism Orthologs (via OrthoDB)
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 13 )
Potential Models Based on Orthology ( 3 )
Modifiers Based on Experimental Evidence ( 1 )
Allele
Disease
Interaction
References
atldsRNA.UAS
model of  hereditary spastic paraplegia 3A
is ameliorated by Tork17004
(Xu et al., 2017)
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
ATL2; atlastin GTPase 2
15 of 15
609368
      ATL1; atlastin GTPase 1
      13 of 15
      606439
      ATL3; atlastin GTPase 3
      12 of 15
      609369
      GBP2; guanylate binding protein 2
      3 of 15
      600412
          GBP3; guanylate binding protein 3
          3 of 15
          600413
              GBP4; guanylate binding protein 4
              3 of 15
              612466
                  GBP5; guanylate binding protein 5
                  3 of 15
                  611467
                      GBP6; guanylate binding protein family member 6
                      3 of 15
                      612467
                          GBP7; guanylate binding protein 7
                          3 of 15
                          612468
                              RNF112; ring finger protein 112
                              3 of 15
                              601237
                                  Functional Complementation Data
                                  Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                  Interactions
                                  Summary of Physical Interactions
                                  Summary of Genetic Interactions
                                  esyN Network Diagram
                                  esyN Network Key:
                                  Suppression
                                  Enhancement
                                  View in Interactions Browser
                                  Please look at the allele data for full details of the genetic interactions
                                  Starting gene(s)
                                  Interaction type
                                  Interacting gene(s)
                                  Reference
                                  atl
                                  suppressible
                                  Rtnl1
                                  (Summerville et al., 2016)
                                  atl
                                  suppressible
                                  spas
                                  (Lee et al., 2009)
                                  atl
                                  suppressible
                                  TER94
                                  (O'Sullivan et al., 2013)
                                  atl
                                  enhanceable
                                  TER94
                                  (O'Sullivan et al., 2013)
                                  Starting gene(s)
                                  Interaction type
                                  Interacting gene(s)
                                  Reference
                                  Rtnl1
                                  suppressible
                                  atl
                                  (Summerville et al., 2016)
                                  External Data
                                  Subunit Structure (UniProtKB)
                                  Homooligomer; trans-homooligomer between proteins on adjacent membranes. Interacts with spas; interaction may regulate microtubule dynamics.
                                  (UniProt, Q9VC57 )
                                  Linkouts
                                  BioGRID - A database of protein and genetic interactions.
                                  DroID - A comprehensive database of gene and protein interactions.
                                  MIST (genetic) - An integrated Molecular Interaction Database
                                  MIST (protein-protein) - An integrated Molecular Interaction Database
                                  Pathways
                                  Signaling Pathways (FlyBase)
                                  Metabolic Pathways
                                  External Data
                                  Linkouts
                                  Genomic Location and Detailed Mapping Data
                                  Chromosome (arm)
                                  3R
                                  Recombination map
                                  3-85
                                  Cytogenetic map
                                  96A13-96A13
                                  Sequence location
                                  FlyBase Computed Cytological Location
                                  Cytogenetic map
                                  Evidence for location
                                  96A13-96A13
                                  Limits computationally determined from genome sequence between P{PZ}crb07207&P{PZ}BRWD305842 and P{EP}CycB3EP3127
                                  Experimentally Determined Cytological Location
                                  Cytogenetic map
                                  Notes
                                  References
                                  Experimentally Determined Recombination Data
                                  Location

                                  3-85

                                  (FlyBase, 2016)

                                  3-84.1

                                  (Comeron et al., 2012)
                                  Left of (cM)
                                  Right of (cM)
                                  Notes
                                  Stocks and Reagents
                                  Stocks (21)
                                  Genomic Clones (20)
                                  cDNA Clones (269)
                                   

                                  Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                                  cDNA clones, fully sequenced
                                  BDGP DGC clones
                                  Other clones
                                    Drosophila Genomics Resource Center cDNA clones

                                    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                    cDNA Clones, End Sequenced (ESTs)
                                    BDGP DGC clones
                                    Other clones
                                    RNAi and Array Information
                                    Linkouts
                                    DRSC - Results frm RNAi screens
                                    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                    Antibody Information
                                    Laboratory Generated Antibodies
                                     

                                    polyclonal

                                    (Lee et al., 2009, Lee et al., 2008)
                                    Commercially Available Antibodies
                                     
                                    Other Information
                                    Relationship to Other Genes
                                    Source for database identify of

                                    Source for identity of: atl CG6668

                                    (Daga, 2004.2.23)
                                    Source for database merge of
                                    Additional comments
                                    Other Comments
                                    Origin and Etymology
                                    Discoverer
                                    Etymology
                                    Identification
                                    External Crossreferences and Linkouts ( 53 )
                                    Sequence Crossreferences
                                    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                    UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                                    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                                    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                    Other crossreferences
                                    AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                                    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                                    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                    DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                                    EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                                    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                    FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                                    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                    Flygut - An atlas of the Drosophila adult midgut
                                    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                    InterPro - A database of protein families, domains and functional sites
                                    KEGG Genes - Molecular building blocks of life in the genomic space.
                                    MARRVEL_MODEL - MARRVEL (model organism gene)
                                    modMine - A data warehouse for the modENCODE project
                                    Linkouts
                                    BioGRID - A database of protein and genetic interactions.
                                    DroID - A comprehensive database of gene and protein interactions.
                                    DRSC - Results frm RNAi screens
                                    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                    FlyMine - An integrated database for Drosophila genomics
                                    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                                    MIST (genetic) - An integrated Molecular Interaction Database
                                    MIST (protein-protein) - An integrated Molecular Interaction Database
                                    Synonyms and Secondary IDs (9)
                                    Datasets (0)
                                    Study focus (0)
                                    Experimental Role
                                    Project
                                    Project Type
                                    Title
                                    Study result (0)
                                    Result
                                    Result Type
                                    Title
                                    References (80)