agro, dNicastrin, nic
component of a proteolytic complex, along with Presenilin, that targets Notch and ß amyloid protein - Zn-dependent exopeptidase - co-expression of the four core γ-secretase components, Presenilin, Nicastrin, Aph-1, and Pen-2 promotes the efficient assembly of mature, proteolytically active γ-secretase
Gene model reviewed during 5.39
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.47
Component of the gamma-secretase complex, a complex composed of a presenilin (Psn) homodimer, nicastrin (Nct), Aph-1 and Pen-2.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Nct using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Nct in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: nct agro
dsRNA made from a cDNA library with primers directed against this gene (+674-1448) is used in S2 cells to assess the effect on Psn maturation.
nct is a novel neurogenic gene required cell autonomously for the transduction of the N signal in responding cells. The nct gene product is required for N signalling and acts specifically at the S3 cleavage step. nct and Psn have a novel function, independent of their role in N signaling, that relates to the organization of the spectrin cytoskeleton.
Loss of nct activity blocks the accumulation of Psn gene product associated with the apical plasma membrane, abolishes Psn-dependent cleavage of the transmembrane domain of N and abrogates N signal transduction.