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Gene Dmel\CG11168

General Information
Symbol	Dmel\CG11168	Species	D. melanogaster
Name		Annotation symbol	CG11168
Feature type	protein_coding_gene	FlyBase ID	FBgn0039249
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	96B6-96B8	Sequence location	3R:20,743,828..20,748,111 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG11168 (FBgn0039249). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 3 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Ankyrin repeat; Ankyrin repeat-containing domain; Phosphotyrosine interaction domain; Pleckstrin homology-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed within 06-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval salivary gland, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult crop, larval/adult midgut, larval/adult hindgut, adult Malpighian tubules, adult salivary gland, larval trachea, adult testis, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1637383_at completely aligns to an exonic region of only a subset of 1 of the 2 FlyBase-annotated transcript isoforms of CG11168. Gene sequence location is 3R:20743828..20748111.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 96B6-96B8   Limits computationally determined from genome sequence between P{EP}CycB3EP3127 and P{PZ}ssh01207
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG11168 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.48 Low-frequency RNA-Seq exon junction(s) not annotated. DGC clone LD23637 appears problematic: unspliced intron
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG11168-RA FBtr0084715  NM_143054   2980   863 CG11168-RC FBtr0306089  NM_001170244   3253   332 CG11168-RD FBtr0337009  NM_001276010   2945   863 CG11168-RE FBtr0337010  NM_001276011   2903   849
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG11168-PA   FBpp0084091   95.6   863   6.86     NP_651311   AAF56367 CG11168-PC   FBpp0297226   36.4   332   8.71     NP_001163715   ACZ95009 CG11168-PD   FBpp0307938   95.6   863   6.86     NP_001262939   AGB96319 CG11168-PE   FBpp0307939   94.1   849   6.77     NP_001262940   AGB96320
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ankyrin repeat (IPR002110) Phosphotyrosine interaction domain (IPR006020) Pleckstrin homology-like domain (IPR011993) Ankyrin repeat-containing domain (IPR020683)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA820164   AA942087   AE014297 AAF56367   AE014297 ACZ95009   AE014297 AGB96319   AE014297 AGB96320   AI455350   AI533737   AY060371 AAL25410   BG632664   BG639641   BQ103480   BT072837   CO305991   EC214826
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VC09 C0PUY1 Q95T22
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval salivary gland, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult crop, larval/adult midgut, larval/adult hindgut, adult Malpighian tubules, adult salivary gland, larval trachea, adult testis, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    67.075 Larval Midgut    101.6 Larval Hindgut    132.4 Larval Malpighian Tubules    77.4 Larval Fat Body    46 Larval Salivary Gland    1101.9 Larval Trachea    158.675 Larval Carcass    189.475 Adult Head    54.5 Adult Eye    59.55 Adult Brain    84 Adult Thoracic-Abdominal Ganglion    87.3 Adult Crop    176.3 Adult Midgut    110.2 Adult Hindgut    149.8 Adult Malpighian Tubules    104.9 Adult Fat Body    65.5 Adult Salivary Gland    319.4 Adult Heart    77.7 Adult VirginFemale Spermatheca    74.9 Adult InseminatedFemale Spermatheca    93.2 Adult Ovary    30.7 Adult Testis    163.2 Adult Male Accessory Gland    664.6 Adult Carcass    91.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    67.075 Larval Midgut    101.6 Larval Hindgut    132.4 Larval Malpighian Tubules    77.4 Larval Fat Body    46 Larval Salivary Gland  (1101.9) Larval Trachea    158.675 Larval Carcass    189.475 Adult Head    54.5 Adult Eye    59.55 Adult Brain    84 Adult Thoracic-Abdominal Ganglion    87.3 Adult Crop    176.3 Adult Midgut    110.2 Adult Hindgut    149.8 Adult Malpighian Tubules    104.9 Adult Fat Body    65.5 Adult Salivary Gland    319.4 Adult Heart    77.7 Adult VirginFemale Spermatheca    74.9 Adult InseminatedFemale Spermatheca    93.2 Adult Ovary    30.7 Adult Testis    163.2 Adult Male Accessory Gland  (664.6) Adult Carcass    91.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    67.075 Larval Midgut    101.6 Larval Hindgut    132.4 Larval Malpighian Tubules    77.4 Larval Fat Body    46 Larval Salivary Gland  (1101.9) Larval Trachea    158.675 Larval Carcass    189.475 Adult Head    54.5 Adult Eye    59.55 Adult Brain    84 Adult Thoracic-Abdominal Ganglion    87.3 Adult Crop    176.3 Adult Midgut    110.2 Adult Hindgut    149.8 Adult Malpighian Tubules    104.9 Adult Fat Body    65.5 Adult Salivary Gland    319.4 Adult Heart    77.7 Adult VirginFemale Spermatheca    74.9 Adult InseminatedFemale Spermatheca    93.2 Adult Ovary    30.7 Adult Testis    163.2 Adult Male Accessory Gland    664.6 Adult Carcass    91.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    67.075 Larval Midgut    101.6 Larval Hindgut    132.4 Larval Malpighian Tubules    77.4 Larval Fat Body    46 Larval Salivary Gland    1101.9 Larval Trachea    158.675 Larval Carcass    189.475 Adult Head    54.5 Adult Eye    59.55 Adult Brain    84 Adult Thoracic-Abdominal Ganglion    87.3 Adult Crop    176.3 Adult Midgut    110.2 Adult Hindgut    149.8 Adult Malpighian Tubules    104.9 Adult Fat Body    65.5 Adult Salivary Gland    319.4 Adult Heart    77.7 Adult VirginFemale Spermatheca    74.9 Adult InseminatedFemale Spermatheca    93.2 Adult Ovary    30.7 Adult Testis    163.2 Adult Male Accessory Gland    664.6 Adult Carcass    91.3 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    67.075 Larval Midgut    101.6 Larval Hindgut    132.4 Larval Malpighian Tubules    77.4 Larval Fat Body    46 Larval Salivary Gland    1101.9 Larval Trachea    158.675 Larval Carcass    189.475 Adult Head    54.5 Adult Eye    59.55 Adult Brain    84 Adult Thoracic-Abdominal Ganglion    87.3 Adult Crop    176.3 Adult Midgut    110.2 Adult Hindgut    149.8 Adult Malpighian Tubules    104.9 Adult Fat Body    65.5 Adult Salivary Gland    319.4 Adult Heart    77.7 Adult VirginFemale Spermatheca    74.9 Adult InseminatedFemale Spermatheca    93.2 Adult Ovary    30.7 Adult Testis    163.2 Adult Male Accessory Gland    664.6 Adult Carcass    91.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    67.075 Larval Midgut    101.6 Larval Hindgut    132.4 Larval Malpighian Tubules    77.4 Larval Fat Body    46 Larval Salivary Gland  (1101.9) Larval Trachea    158.675 Larval Carcass    189.475 Adult Head    54.5 Adult Eye    59.55 Adult Brain    84 Adult Thoracic-Abdominal Ganglion    87.3 Adult Crop    176.3 Adult Midgut    110.2 Adult Hindgut    149.8 Adult Malpighian Tubules    104.9 Adult Fat Body    65.5 Adult Salivary Gland    319.4 Adult Heart    77.7 Adult VirginFemale Spermatheca    74.9 Adult InseminatedFemale Spermatheca    93.2 Adult Ovary    30.7 Adult Testis    163.2 Adult Male Accessory Gland  664.6 Adult Carcass    91.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    67.075 Larval Midgut    101.6 Larval Hindgut    132.4 Larval Malpighian Tubules    77.4 Larval Fat Body    46 Larval Salivary Gland  1101.9 Larval Trachea    158.675 Larval Carcass    189.475 Adult Head    54.5 Adult Eye    59.55 Adult Brain    84 Adult Thoracic-Abdominal Ganglion    87.3 Adult Crop    176.3 Adult Midgut    110.2 Adult Hindgut    149.8 Adult Malpighian Tubules    104.9 Adult Fat Body    65.5 Adult Salivary Gland    319.4 Adult Heart    77.7 Adult VirginFemale Spermatheca    74.9 Adult InseminatedFemale Spermatheca    93.2 Adult Ovary    30.7 Adult Testis    163.2 Adult Male Accessory Gland    664.6 Adult Carcass    91.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    67.075 Larval Midgut    101.6 Larval Hindgut    132.4 Larval Malpighian Tubules    77.4 Larval Fat Body    46 Larval Salivary Gland    1101.9 Larval Trachea    158.675 Larval Carcass    189.475 Adult Head    54.5 Adult Eye    59.55 Adult Brain    84 Adult Thoracic-Abdominal Ganglion    87.3 Adult Crop    176.3 Adult Midgut    110.2 Adult Hindgut    149.8 Adult Malpighian Tubules    104.9 Adult Fat Body    65.5 Adult Salivary Gland    319.4 Adult Heart    77.7 Adult VirginFemale Spermatheca    74.9 Adult InseminatedFemale Spermatheca    93.2 Adult Ovary    30.7 Adult Testis    163.2 Adult Male Accessory Gland    664.6 Adult Carcass    91.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    54.5   NA  Eye    59.55   NA  Brain    84   67.075  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    87.3   NA  Crop    176.3   101.6  Midgut    110.2   132.4  Hindgut    149.8   77.4  Malpighian Tubules    104.9   46  Fat Body    65.5   1101.9  Salivary Gland    319.4   NA  Heart    77.7   158.675  Trachea    NA   NA  VirginFemale Spermatheca    74.9   NA  InseminatedFemale Spermatheca    93.2   NA  Ovary    30.7   NA  Testis    163.2   NA  Male Accessory Gland    664.6   189.475  Carcass    91.3 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    10 central nervous system, pupae P8    5 head, virgin 1-day female    5 head, virgin 4-day female    5 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    5 head, mated 20-day female    4 head, mated 1-day male    5 head, mated 4-day male    7 head, mated 20-day male    10 salivary gland, larvae L3 wandering    14 salivary gland, white prepupae    26 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    8 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    5 fat body, white prepupae    4 fat body, pupae P8    6 carcass, larvae L3 wandering    11 carcass, 1-day adult    6 carcass, 4-day adult    6 carcass, 20-day adult    5 ovary, virgin 4-day female    7 ovary, mated 4-day female    8 testis, mated 4-day male    18 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    10 central nervous system, pupae P8    5 head, virgin 1-day female    5 head, virgin 4-day female    5 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    5 head, mated 20-day female    4 head, mated 1-day male    5 head, mated 4-day male    7 head, mated 20-day male    10 salivary gland, larvae L3 wandering    14 salivary gland, white prepupae  26 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    8 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    5 fat body, white prepupae    4 fat body, pupae P8    6 carcass, larvae L3 wandering    11 carcass, 1-day adult    6 carcass, 4-day adult    6 carcass, 20-day adult    5 ovary, virgin 4-day female    7 ovary, mated 4-day female    8 testis, mated 4-day male    18 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    10 central nervous system, pupae P8    5 head, virgin 1-day female    5 head, virgin 4-day female    5 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    5 head, mated 20-day female    4 head, mated 1-day male    5 head, mated 4-day male    7 head, mated 20-day male    10 salivary gland, larvae L3 wandering    14 salivary gland, white prepupae    26 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    8 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    5 fat body, white prepupae    4 fat body, pupae P8    6 carcass, larvae L3 wandering    11 carcass, 1-day adult    6 carcass, 4-day adult    6 carcass, 20-day adult    5 ovary, virgin 4-day female    7 ovary, mated 4-day female    8 testis, mated 4-day male    18 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    10 central nervous system, pupae P8    5 head, virgin 1-day female    5 head, virgin 4-day female    5 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    5 head, mated 20-day female    4 head, mated 1-day male    5 head, mated 4-day male    7 head, mated 20-day male    10 salivary gland, larvae L3 wandering    14 salivary gland, white prepupae    26 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    8 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    5 fat body, white prepupae    4 fat body, pupae P8    6 carcass, larvae L3 wandering    11 carcass, 1-day adult    6 carcass, 4-day adult    6 carcass, 20-day adult    5 ovary, virgin 4-day female    7 ovary, mated 4-day female    8 testis, mated 4-day male    18 accessory gland, mated 4-day male    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    10 central nervous system, pupae P8    5 head, virgin 1-day female    5 head, virgin 4-day female    5 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    5 head, mated 20-day female    4 head, mated 1-day male    5 head, mated 4-day male    7 head, mated 20-day male    10 salivary gland, larvae L3 wandering    14 salivary gland, white prepupae    26 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    8 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    5 fat body, white prepupae    4 fat body, pupae P8    6 carcass, larvae L3 wandering    11 carcass, 1-day adult    6 carcass, 4-day adult    6 carcass, 20-day adult    5 ovary, virgin 4-day female    7 ovary, mated 4-day female    8 testis, mated 4-day male    18 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    10 central nervous system, pupae P8    5 head, virgin 1-day female    5 head, virgin 4-day female    5 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    5 head, mated 20-day female    4 head, mated 1-day male    5 head, mated 4-day male    7 head, mated 20-day male    10 salivary gland, larvae L3 wandering    14 salivary gland, white prepupae  26 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    8 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    5 fat body, white prepupae    4 fat body, pupae P8    6 carcass, larvae L3 wandering    11 carcass, 1-day adult    6 carcass, 4-day adult    6 carcass, 20-day adult    5 ovary, virgin 4-day female    7 ovary, mated 4-day female    8 testis, mated 4-day male    18 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    10 central nervous system, pupae P8    5 head, virgin 1-day female    5 head, virgin 4-day female    5 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    5 head, mated 20-day female    4 head, mated 1-day male    5 head, mated 4-day male    7 head, mated 20-day male    10 salivary gland, larvae L3 wandering    14 salivary gland, white prepupae    26 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    8 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    5 fat body, white prepupae    4 fat body, pupae P8    6 carcass, larvae L3 wandering    11 carcass, 1-day adult    6 carcass, 4-day adult    6 carcass, 20-day adult    5 ovary, virgin 4-day female    7 ovary, mated 4-day female    8 testis, mated 4-day male    18 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    9 central nervous system, larvae L3    10 central nervous system, pupae P8    5 head, virgin 1-day female    5 head, virgin 4-day female    5 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    5 head, mated 20-day female    4 head, mated 1-day male    5 head, mated 4-day male    7 head, mated 20-day male    10 salivary gland, larvae L3 wandering    14 salivary gland, white prepupae    26 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    8 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    5 fat body, white prepupae    4 fat body, pupae P8    6 carcass, larvae L3 wandering    11 carcass, 1-day adult    6 carcass, 4-day adult    6 carcass, 20-day adult    5 ovary, virgin 4-day female    7 ovary, mated 4-day female    8 testis, mated 4-day male    18 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed within 06-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    2 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    6 embryo 10-12hr    7 embryo 12-14hr    7 embryo 14-16hr    8 embryo 16-18hr    12 embryo 18-20hr    17 embryo 20-22hr    13 embryo 22-24hr    14 larva L1    10 larva L2    9 larva L3 12hr old    8 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    10 white prepupae new    8 white prepupae 12hr    9 white prepupae 24hr    9 pupae 2d postWPP    8 pupae 3d postWPP    8 pupae 4d postWPP    6 adult male 01day    10 adult male 05day    12 adult male 30day    13 adult female 01day    8 adult female 05day    6 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    2 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    6 embryo 10-12hr    7 embryo 12-14hr    7 embryo 14-16hr    8 embryo 16-18hr    12 embryo 18-20hr    17 embryo 20-22hr    13 embryo 22-24hr    14 larva L1    10 larva L2    9 larva L3 12hr old    8 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    10 white prepupae new    8 white prepupae 12hr    9 white prepupae 24hr    9 pupae 2d postWPP    8 pupae 3d postWPP    8 pupae 4d postWPP    6 adult male 01day    10 adult male 05day    12 adult male 30day    13 adult female 01day    8 adult female 05day    6 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    2 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    6 embryo 10-12hr    7 embryo 12-14hr    7 embryo 14-16hr    8 embryo 16-18hr    12 embryo 18-20hr    17 embryo 20-22hr    13 embryo 22-24hr    14 larva L1    10 larva L2    9 larva L3 12hr old    8 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    10 white prepupae new    8 white prepupae 12hr    9 white prepupae 24hr    9 pupae 2d postWPP    8 pupae 3d postWPP    8 pupae 4d postWPP    6 adult male 01day    10 adult male 05day    12 adult male 30day    13 adult female 01day    8 adult female 05day    6 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    2 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    6 embryo 10-12hr    7 embryo 12-14hr    7 embryo 14-16hr    8 embryo 16-18hr    12 embryo 18-20hr    17 embryo 20-22hr    13 embryo 22-24hr    14 larva L1    10 larva L2    9 larva L3 12hr old    8 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    10 white prepupae new    8 white prepupae 12hr    9 white prepupae 24hr    9 pupae 2d postWPP    8 pupae 3d postWPP    8 pupae 4d postWPP    6 adult male 01day    10 adult male 05day    12 adult male 30day    13 adult female 01day    8 adult female 05day    6 adult female 30day    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    2 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    6 embryo 10-12hr    7 embryo 12-14hr    7 embryo 14-16hr    8 embryo 16-18hr    12 embryo 18-20hr    17 embryo 20-22hr    13 embryo 22-24hr    14 larva L1    10 larva L2    9 larva L3 12hr old    8 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    10 white prepupae new    8 white prepupae 12hr    9 white prepupae 24hr    9 pupae 2d postWPP    8 pupae 3d postWPP    8 pupae 4d postWPP    6 adult male 01day    10 adult male 05day    12 adult male 30day    13 adult female 01day    8 adult female 05day    6 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    2 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    6 embryo 10-12hr    7 embryo 12-14hr    7 embryo 14-16hr    8 embryo 16-18hr    12 embryo 18-20hr    17 embryo 20-22hr    13 embryo 22-24hr    14 larva L1    10 larva L2    9 larva L3 12hr old    8 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    10 white prepupae new    8 white prepupae 12hr    9 white prepupae 24hr    9 pupae 2d postWPP    8 pupae 3d postWPP    8 pupae 4d postWPP    6 adult male 01day    10 adult male 05day    12 adult male 30day    13 adult female 01day    8 adult female 05day    6 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    2 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    6 embryo 10-12hr    7 embryo 12-14hr    7 embryo 14-16hr    8 embryo 16-18hr    12 embryo 18-20hr    17 embryo 20-22hr    13 embryo 22-24hr    14 larva L1    10 larva L2    9 larva L3 12hr old    8 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    10 white prepupae new    8 white prepupae 12hr    9 white prepupae 24hr    9 pupae 2d postWPP    8 pupae 3d postWPP    8 pupae 4d postWPP    6 adult male 01day    10 adult male 05day    12 adult male 30day    13 adult female 01day    8 adult female 05day    6 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    2 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    6 embryo 10-12hr    7 embryo 12-14hr    7 embryo 14-16hr    8 embryo 16-18hr    12 embryo 18-20hr    17 embryo 20-22hr    13 embryo 22-24hr    14 larva L1    10 larva L2    9 larva L3 12hr old    8 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    10 white prepupae new    8 white prepupae 12hr    9 white prepupae 24hr    9 pupae 2d postWPP    8 pupae 3d postWPP    8 pupae 4d postWPP    6 adult male 01day    10 adult male 05day    12 adult male 30day    13 adult female 01day    8 adult female 05day    6 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    8 embryonic 1182-4H    13 embryonic GM2    9 embryonic Kc167    9 embryonic S1    7 embryonic S3    7 leg disc CME L1    10 wing disc CME-W2    6 wing disc ML-DmD8    10 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    13 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    7 ovary fGS/OSS    13 ovary OSC    9 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    8 embryonic 1182-4H    13 embryonic GM2    9 embryonic Kc167    9 embryonic S1    7 embryonic S3    7 leg disc CME L1    10 wing disc CME-W2    6 wing disc ML-DmD8    10 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    13 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    7 ovary fGS/OSS    13 ovary OSC    9 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    8 embryonic 1182-4H    13 embryonic GM2    9 embryonic Kc167    9 embryonic S1    7 embryonic S3    7 leg disc CME L1    10 wing disc CME-W2    6 wing disc ML-DmD8    10 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    13 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    7 ovary fGS/OSS    13 ovary OSC    9 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    8 embryonic 1182-4H    13 embryonic GM2    9 embryonic Kc167    9 embryonic S1    7 embryonic S3    7 leg disc CME L1    10 wing disc CME-W2    6 wing disc ML-DmD8    10 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    13 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    7 ovary fGS/OSS    13 ovary OSC    9 ovary OSS    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    8 embryonic 1182-4H    13 embryonic GM2    9 embryonic Kc167    9 embryonic S1    7 embryonic S3    7 leg disc CME L1    10 wing disc CME-W2    6 wing disc ML-DmD8    10 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    13 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    7 ovary fGS/OSS    13 ovary OSC    9 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    8 embryonic 1182-4H    13 embryonic GM2    9 embryonic Kc167    9 embryonic S1    7 embryonic S3    7 leg disc CME L1    10 wing disc CME-W2    6 wing disc ML-DmD8    10 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    13 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    7 ovary fGS/OSS    13 ovary OSC    9 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    8 embryonic 1182-4H    13 embryonic GM2    9 embryonic Kc167    9 embryonic S1    7 embryonic S3    7 leg disc CME L1    10 wing disc CME-W2    6 wing disc ML-DmD8    10 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    13 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    7 ovary fGS/OSS    13 ovary OSC    9 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    8 embryonic 1182-4H    13 embryonic GM2    9 embryonic Kc167    9 embryonic S1    7 embryonic S3    7 leg disc CME L1    10 wing disc CME-W2    6 wing disc ML-DmD8    10 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    13 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    7 ovary fGS/OSS    13 ovary OSC    9 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    9 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    9 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    9 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    9 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    9 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    9 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    9 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    9 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_18 mE1_20_mRNA_expression_cluster_14
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039249 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11168-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 CG11168GD7221 viable CG11168EY16053 Sterility Allele fertile CG11168EY16053 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of CG11168 Class Mutagen Stocks Known lesion CG11168EY16053 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG11168 Class Mutagen Stocks Known lesion CG11168GD7221 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG11168KK107156 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7221} NA P{KK107156} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}CG11168EY16053 NA
Gene Ontology: Function, Process & Cellular Component ( 0 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG11168 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67902 DroID - A comprehensive database of gene and protein interactions. • FBgn0039249 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42981 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q95T22
Orthologs
OrthoDB Orthologs (28) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6TXCB9 Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search EOG6CZ99Q Arthropod inclusive ortholog search EOG683BKF Metazoa inclusive ortholog search EOG6J74HJ
Orthologs in Drosophila Species (EOG6TXCB9)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG11168     Drosophila simulans   Dsim\GD21146 Y   Drosophila sechellia   Dsec\GM17770 Y   Drosophila erecta   Dere\GG11336 Y   Drosophila yakuba   Dyak\GE23531 Y   Drosophila ananassae   Dana\GF16312 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA10812 Y   Drosophila persimilis   Dper\GL24400 Y   Drosophila willistoni   Dwil\GK12974 Y   Drosophila virilis   Dvir\GJ10707 Y   Drosophila mojavensis   Dmoj\GI24433 Y   Drosophila grimshawi   Dgri\GH14057 Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (EOG6CZ99Q)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB41505 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG015859 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH20834 Y Atta cephalotes Leafcutter ant  Acep\ACEP24458 Y Atta cephalotes Leafcutter ant  Acep\ACEP24463 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO18354 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL13751 Y Linepithema humile Argentine ant  Lhum\LH15464 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB25554 Y Solenopsis invicta Red fire ant  Sinv\SINV14477 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI002478 Y Pediculus humanus Human body louse  Phum\PHUM097030 Y Tribolium castaneum Red flour beetle  Tcas\GLEAN_07410 Y
Orthologs in non-Insect Arthropods (EOG683BKF)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_107593 Y Ixodes scapularis Deer tick  Isca\ISCW021777 Y
Orthologs in non-Arthropod Metazoa (EOG6J74HJ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\C11E4.6 Y
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD21146 Drosophila sechellia Dsec\GM17770 Drosophila erecta Dere\GG11336 Drosophila yakuba Dyak\GE23531 Drosophila ananassae Dana\GF16312 Drosophila pseudoobscura pseudoobscura Dpse\GA10812 Drosophila persimilis Dper\GL24400 Drosophila willistoni Dwil\GK12974 Drosophila virilis Dvir\GJ10707 Drosophila mojavensis Dmoj\GI24433 Drosophila grimshawi Dgri\GH14057
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	21183 y1 w67c23; P{EPgy2}CG11168EY16053
VDRC	v106085 P{KK107156}VIE-260B v18171 w1118 P{GD7221}v18171 v18170 w1118; P{GD7221}v18170
Genomic Clones ( 2 )
	BACR03I15 BACR33F18 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 9 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT25426 LD23637
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD26122 SD05685
Other clones	147327 EK249949 GH12114 SD03844 UUGC0886
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0039249 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42981
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_143054 NM_001170244 NM_001276010 NM_001276011 RefSeq (Proteins) • NP_651311 NP_001163715 NP_001262939 NP_001262940 DDBJ / EMBL / GenBank • AA820164 AAF56367 AAL25410 ACZ95009 AGB96319 AGB96320 AI455350 AY060371 Entrez Gene - A searchable database of RefSeq genes. • 42981 UniProtKB/TrEMBL • C0PUY1 Q9VC09 Q95T22
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ankyrin repeat (IPR002110) Phosphotyrosine interaction domain (IPR006020) Pleckstrin homology-like domain (IPR011993) Ankyrin repeat-containing domain (IPR020683)
Linkouts
	BioGRID - A database of protein and genetic interactions • 67902 DroID - A comprehensive database of gene and protein interactions. • FBgn0039249 DRSC - Results from RNAi screens. • FBgn0039249 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039249 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11168-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0039249 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42981 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42981 modMine - Data generated by the modENCODE project. • FBgn0039249 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q95T22
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG11168 (Nakamura et al., 2008, Keleman et al., 2009.8.5, Kim et al., 2005)
Name Synonym
Secondary FlyBase IDs
References ( 16 )
Research paper	Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Nakamura et al., 2008, Mol. Cell. Biol. 28(21): 6620--6631 TRF4 is involved in polyadenylation of snRNAs in Drosophila melanogaster. [FBrf0207153] Kim et al., 2005, Nat. Immunol. 6(2): 211--218 Downregulation of lipopolysaccharide response in Drosophila by negative crosstalk between the AP1 and NF-kappaB signaling modules. [FBrf0184193]
Supplementary material	Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452] Kiger et al., 2003, J. Biol. 2(4): Additional data file 1: The gene identity and primer sequences for dsRNAs used in the RNAi screens. [FBrf0174231]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Gene Disruption Project members, 2001-, (Computer file) (Computer file) [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]
FlyBase analysis	FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]
Curated genome annotation	FamiliarityBreedsContempt, 1999.11, [Automatic annotations performed at the Celera Jamboreee.] [Automatic annotations performed at the Celera Jamboreee.] [FBrf0126705] Zhao, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126701]