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Gene Dmel\tnc

General Information
Symbol	Dmel\tnc	Species	D. melanogaster
Name	tenectin	Annotation symbol	CG13648
Feature type	protein_coding_gene	FlyBase ID	FBgn0039257
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	96B15-96B15	Sequence location	3R:20,810,106..20,848,589 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene tenectin is referred to in FlyBase by the symbol Dmel\tnc (CG13648, FBgn0039257). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: integrin binding. There is experimental evidence that it is involved in the biological process: wing disc morphogenesis; embryonic hindgut morphogenesis; imaginal disc-derived male genitalia morphogenesis; epithelial tube morphogenesis; regulation of tube diameter; imaginal disc-derived wing morphogenesis. 8 alleles are reported. The phenotypes of these alleles are annotated with: organ system; organ system subdivision; multicellular structure; embryonic hindgut; adult segment; portion of tissue; thoracic segment; anatomical structure; non-connected developing system; region of integument. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: von Willebrand factor, type C. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression. Peak expression observed during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Gene sequence location is 3R:20810106..20848589.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 96B15-96B15   Limits computationally determined from genome sequence between P{PZ}ssh01207 and P{lacW}OstStt3j2D9
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\tnc for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) tnc-RC FBtr0305667  NM_143061   10374   2819 tnc-RD FBtr0305668  NM_001260371   10280   2819
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein tnc-PC   FBpp0296947   299.6   2819   3.73     NP_651318   AAF56376 tnc-PD   FBpp0296948   299.6   2819   3.73     NP_001247300   AFH06617
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • von Willebrand factor, type C (IPR001007)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141414   AE014297 AAF56376   AE014297 AFH06617   BI576450   BI582763   BI585381   BI589159   BI607556   BI634198   BT088812   BT088813   CK135131   CK657133   CO279969   CO291976   CO303665   CO307535   CO309183   EC065626   EC077781   EC086529   EC214929   EC215144   EC237608   EC252253   EW713071   EW713101   EY199010
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VC00
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
extracellular matrix inferred from direct assay (Fraichard et al., 2006) extracellular space inferred from direct assay (Syed et al., 2012)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    63 central nervous system, larvae L3    114 central nervous system, pupae P8    38 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    5 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    6 head, mated 1-day male    8 head, mated 4-day male    7 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    13 digestive system, larvae L3 wandering    34 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    30 fat body, pupae P8    20 carcass, larvae L3 wandering    131 carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    6 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    6 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (63) central nervous system, larvae L3  (114) central nervous system, pupae P8  (38) head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    5 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    6 head, mated 1-day male    8 head, mated 4-day male    7 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    13 digestive system, larvae L3 wandering  (34) digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae  (30) fat body, pupae P8    20 carcass, larvae L3 wandering  (131) carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    6 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    6 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    63 central nervous system, larvae L3  (114) central nervous system, pupae P8    38 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    5 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    6 head, mated 1-day male    8 head, mated 4-day male    7 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    13 digestive system, larvae L3 wandering    34 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    30 fat body, pupae P8    20 carcass, larvae L3 wandering  (131) carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    6 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    6 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    63 central nervous system, larvae L3    114 central nervous system, pupae P8    38 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    5 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    6 head, mated 1-day male    8 head, mated 4-day male    7 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    13 digestive system, larvae L3 wandering    34 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    30 fat body, pupae P8    20 carcass, larvae L3 wandering    131 carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    6 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    6 accessory gland, mated 4-day male    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    63 central nervous system, larvae L3    114 central nervous system, pupae P8    38 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    5 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    6 head, mated 1-day male    8 head, mated 4-day male    7 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    13 digestive system, larvae L3 wandering    34 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    30 fat body, pupae P8    20 carcass, larvae L3 wandering    131 carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    6 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    6 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (63) central nervous system, larvae L3  (114) central nervous system, pupae P8  (38) head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    5 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    6 head, mated 1-day male    8 head, mated 4-day male    7 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    13 digestive system, larvae L3 wandering  (34) digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae  30 fat body, pupae P8    20 carcass, larvae L3 wandering  (131) carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    6 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    6 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    63 central nervous system, larvae L3  114 central nervous system, pupae P8    38 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    5 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    6 head, mated 1-day male    8 head, mated 4-day male    7 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    13 digestive system, larvae L3 wandering    34 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    30 fat body, pupae P8    20 carcass, larvae L3 wandering  131 carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    6 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    6 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    63 central nervous system, larvae L3    114 central nervous system, pupae P8    38 head, virgin 1-day female    6 head, virgin 4-day female    5 head, virgin 20-day female    5 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    6 head, mated 1-day male    8 head, mated 4-day male    7 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    13 digestive system, larvae L3 wandering    34 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    30 fat body, pupae P8    20 carcass, larvae L3 wandering    131 carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    6 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    6 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression. Peak expression observed during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    3 embryo 08-10hr    6 embryo 10-12hr    7 embryo 12-14hr    32 embryo 14-16hr    17 embryo 16-18hr    4 embryo 18-20hr    6 embryo 20-22hr    11 embryo 22-24hr    12 larva L1    10 larva L2    46 larva L3 12hr old    17 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    18 larva L3 puffstage 7-9    51 white prepupae new    77 white prepupae 12hr    16 white prepupae 24hr    102 pupae 2d postWPP    43 pupae 3d postWPP    2 pupae 4d postWPP    4 adult male 01day    4 adult male 05day    4 adult male 30day    4 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    3 embryo 08-10hr    6 embryo 10-12hr    7 embryo 12-14hr  (32) embryo 14-16hr    17 embryo 16-18hr    4 embryo 18-20hr    6 embryo 20-22hr    11 embryo 22-24hr    12 larva L1    10 larva L2  (46) larva L3 12hr old    17 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    18 larva L3 puffstage 7-9  (51) white prepupae new  (77) white prepupae 12hr    16 white prepupae 24hr  (102) pupae 2d postWPP  (43) pupae 3d postWPP    2 pupae 4d postWPP    4 adult male 01day    4 adult male 05day    4 adult male 30day    4 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    3 embryo 08-10hr    6 embryo 10-12hr    7 embryo 12-14hr    32 embryo 14-16hr    17 embryo 16-18hr    4 embryo 18-20hr    6 embryo 20-22hr    11 embryo 22-24hr    12 larva L1    10 larva L2    46 larva L3 12hr old    17 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    18 larva L3 puffstage 7-9    51 white prepupae new    77 white prepupae 12hr    16 white prepupae 24hr  102 pupae 2d postWPP    43 pupae 3d postWPP    2 pupae 4d postWPP    4 adult male 01day    4 adult male 05day    4 adult male 30day    4 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    3 embryo 08-10hr    6 embryo 10-12hr    7 embryo 12-14hr    32 embryo 14-16hr    17 embryo 16-18hr    4 embryo 18-20hr    6 embryo 20-22hr    11 embryo 22-24hr    12 larva L1    10 larva L2    46 larva L3 12hr old    17 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    18 larva L3 puffstage 7-9    51 white prepupae new    77 white prepupae 12hr    16 white prepupae 24hr    102 pupae 2d postWPP    43 pupae 3d postWPP    2 pupae 4d postWPP    4 adult male 01day    4 adult male 05day    4 adult male 30day    4 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    3 embryo 08-10hr    6 embryo 10-12hr    7 embryo 12-14hr    32 embryo 14-16hr    17 embryo 16-18hr    4 embryo 18-20hr    6 embryo 20-22hr    11 embryo 22-24hr    12 larva L1    10 larva L2    46 larva L3 12hr old    17 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    18 larva L3 puffstage 7-9    51 white prepupae new    77 white prepupae 12hr    16 white prepupae 24hr    102 pupae 2d postWPP    43 pupae 3d postWPP    2 pupae 4d postWPP    4 adult male 01day    4 adult male 05day    4 adult male 30day    4 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    3 embryo 08-10hr    6 embryo 10-12hr    7 embryo 12-14hr  32 embryo 14-16hr    17 embryo 16-18hr    4 embryo 18-20hr    6 embryo 20-22hr    11 embryo 22-24hr    12 larva L1    10 larva L2  (46) larva L3 12hr old    17 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    18 larva L3 puffstage 7-9  (51) white prepupae new  (77) white prepupae 12hr    16 white prepupae 24hr  (102) pupae 2d postWPP  (43) pupae 3d postWPP    2 pupae 4d postWPP    4 adult male 01day    4 adult male 05day    4 adult male 30day    4 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    3 embryo 08-10hr    6 embryo 10-12hr    7 embryo 12-14hr    32 embryo 14-16hr    17 embryo 16-18hr    4 embryo 18-20hr    6 embryo 20-22hr    11 embryo 22-24hr    12 larva L1    10 larva L2    46 larva L3 12hr old    17 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    18 larva L3 puffstage 7-9    51 white prepupae new    77 white prepupae 12hr    16 white prepupae 24hr  102 pupae 2d postWPP    43 pupae 3d postWPP    2 pupae 4d postWPP    4 adult male 01day    4 adult male 05day    4 adult male 30day    4 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    3 embryo 08-10hr    6 embryo 10-12hr    7 embryo 12-14hr    32 embryo 14-16hr    17 embryo 16-18hr    4 embryo 18-20hr    6 embryo 20-22hr    11 embryo 22-24hr    12 larva L1    10 larva L2    46 larva L3 12hr old    17 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    18 larva L3 puffstage 7-9    51 white prepupae new    77 white prepupae 12hr    16 white prepupae 24hr    102 pupae 2d postWPP    43 pupae 3d postWPP    2 pupae 4d postWPP    4 adult male 01day    4 adult male 05day    4 adult male 30day    4 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    13 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    13 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    13 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    13 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    13 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    13 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    13 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    13 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_25
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039257 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG13648-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4Act5C.PI tncdsRNA.Scer\UAS.cFa tncEY16369 lethal, with Scer\GAL4da.G32 tncdsRNA.Scer\UAS.cFa viable tnc81b viable, with Scer\GAL4pnr-MD237 tncGD14952 Other Phenotypes Allele visible, with Scer\GAL4Act5C.PI tncdsRNA.Scer\UAS.cFa visible, with Scer\GAL4pnr-MD237 tncGD14952 Phenotype manifest in Allele embryonic/larval dorsal trunk tnc13c embryonic/larval dorsal trunk, with Scer\GAL4btl.PS tncEY16369 embryonic/larval hindgut tnc130a embryonic/larval hindgut (with Df(3R)BSC655) tnc13c embryonic/larval hindgut | embryonic stage 14 tnc13c embryonic/larval hindgut | embryonic stage 16 tnc13c embryonic/larval salivary gland, with Scer\GAL469B tncEY16369 embryonic/larval salivary gland, with Scer\GAL4en-e16E tncEY16369 embryonic large intestine tnc13c embryonic large intestine, with Scer\GAL469B tncEY16369 embryonic large intestine, with Scer\GAL4byn-Gal4 tncEY16369 embryonic large intestine, with Scer\GAL4drm.7.1 tncEY16369 embryonic large intestine, with Scer\GAL4en-e16E tncEY16369 embryonic Malpighian tubule, with Scer\GAL4drm.7.1 tncEY16369 embryonic small intestine tnc13c embryonic small intestine, with Scer\GAL469B tncEY16369 embryonic small intestine, with Scer\GAL4byn-Gal4 tncEY16369 embryonic small intestine, with Scer\GAL4drm.7.1 tncEY16369 male genitalia, with Scer\GAL4Act5C.PI tncdsRNA.Scer\UAS.cFa male genitalia, with Scer\GAL4da.G32 tncdsRNA.Scer\UAS.cFa male genitalia, with Scer\GAL4T80 tncdsRNA.Scer\UAS.cFa mesothoracic tergum, with Scer\GAL4pnr-MD237 tncGD14952 primary trachea, with Scer\GAL4btl.PS tncEY16369 wing, with Scer\GAL4Act5C.PI tncdsRNA.Scer\UAS.cFa tncEY16369 wing margin, with Scer\GAL4Act5C.PI tncdsRNA.Scer\UAS.cFa
Classical Alleles ( 5 )
For All Classical Alleles Show
Allele of tnc Class Mutagen Stocks Known lesion tncEY16369 1 -- tncMB04464 1 -- tnc13c amorphic allele - molecular evidence P-element activity 0 Yes tnc130a P-element activity 0 Yes tnc81b P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of tnc Class Mutagen Stocks Known lesion tncGD14952 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes tncdsRNA.Scer\UAS.cFa in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes tncNIG.13648R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD14952} NA P{NIG.13648R} NA P{UAS-tnc.IR} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}tncEY16369 NA insertion of enhancer trap binary system Mi{ET1}tncMB04464 No
Gene Ontology: Function, Process & Cellular Component ( 10 unique terms )
Terms Based on Experimental Evidence ( 9 terms )
Molecular Function
CV term Evidence References
integrin binding inferred from direct assay (Bouge et al., 2005)
Biological Process
CV term Evidence References
embryonic hindgut morphogenesis inferred from mutant phenotype (Syed et al., 2012) epithelial tube morphogenesis inferred from mutant phenotype (Syed et al., 2012) imaginal disc-derived male genitalia morphogenesis inferred from mutant phenotype (Fraichard et al., 2010) imaginal disc-derived wing morphogenesis inferred from mutant phenotype (Fraichard et al., 2010) regulation of tube diameter inferred from mutant phenotype (Syed et al., 2012) wing disc morphogenesis inferred from mutant phenotype (Bouge et al., 2005)
Cellular Component
CV term Evidence References
extracellular matrix inferred from direct assay (Fraichard et al., 2006) extracellular space inferred from direct assay (Syed et al., 2012)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
extracellular matrix structural constituent inferred from sequence model (Syed et al., 2008)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
extracellular matrix inferred from sequence model (Syed et al., 2008)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions tnc allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0039257
Orthologs
OrthoDB Orthologs (27) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6VX2RF Dipteran inclusive ortholog search EOG63BMXV Insect inclusive ortholog search EOG695XNS Arthropod inclusive ortholog search EOG6JDFPQ Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6VX2RF)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\tnc     Drosophila sechellia   Dsec\GM17782     Drosophila erecta   Dere\GG11343 Y   Drosophila yakuba   Dyak\GE23539 Y   Drosophila ananassae   Dana\GF16318 Y   Drosophila ananassae   Dana\GF24861     Drosophila ananassae   Dana\GF19055     Drosophila willistoni   Dwil\GK12979 Y   Drosophila virilis   Dvir\GJ24342 Y   Drosophila virilis   Dvir\GJ21213
Orthologs in non-Drosophila Dipterans (EOG63BMXV)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL005529
Orthologs in non-Dipteran Insects (EOG695XNS)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG006769   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH23266   Atta cephalotes Leafcutter ant  Acep\ACEP12787   Camponotus floridanus Florida carpenter ant  Cflo\CFLO12686   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL14336   Linepithema humile Argentine ant  Lhum\LH23770   Pogonomyrmex barbatus Red harvester ant  Pbar\PB15686   Pogonomyrmex barbatus Red harvester ant  Pbar\PB15044   Pogonomyrmex barbatus Red harvester ant  Pbar\PB24206   Solenopsis invicta Red fire ant  Sinv\SINV10867   Acyrthosiphon pisum Pea aphid  Apim\ACYPI003639   Bombyx mori Silkmoth  Bmor\BGIBMGA006846   Pediculus humanus Human body louse  Phum\PHUM014740   Tribolium castaneum Red flour beetle  Tcas\TC012717
Orthologs in non-Insect Arthropods (EOG6JDFPQ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Ixodes scapularis Deer tick  Isca\ISCW000348   Ixodes scapularis Deer tick  Isca\ISCW004511
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD21156 Drosophila erecta Dere\GG11343 Drosophila yakuba Dyak\GE23539 Drosophila ananassae Dana\GF16318 Drosophila pseudoobscura pseudoobscura Dpse\GA26604 Drosophila persimilis Dper\GL24408 Drosophila willistoni Dwil\GK12979 Drosophila virilis Dvir\GJ24342 Drosophila mojavensis Dmoj\GI22221 Drosophila grimshawi Dgri\GH19461
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	24708 w1118; Mi{ET1}tncMB04464 21205 y1 w67c23; P{EPgy2}tncEY16369
VDRC	v42326 w1118; P{GD14952}v42326 v42327 w1118; P{GD14952}v42327/TM3
Genomic Clones ( 2 )
	BACR03I15 BACR03L02 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 22 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones	MIP09726 MIP09926
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LP23181 RH21064 RH31507 RH33017 RH37623 RH74646
Other clones	71326 120553 149190 157298 157390 214509.18 CK01702 DMG2-chr3R.21.132.a.1 EK152107 EK198916 EK242336 EK254759 EK260559 RH24925
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0039257 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42990
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: tnc CG13648 (Bouge, 2005.9.8)
Source for database merge of
Additional comments
Other Comments
	tnc promotes diameter expansion of the hindgut in a dose-dependent manner. Luminal accumulation of tnc protein causes an increase in inner and outer tube diameter and cell flattening within the tube wall. The protein appears to act non-autonomously. (Syed et al., 2012)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_143061 NM_001260371 RefSeq (Proteins) • NP_651318 NP_001247300 DDBJ / EMBL / GenBank • AAF56376 AFH06617 BI585381 Entrez Gene - A searchable database of RefSeq genes. • 42990 UniProtKB/TrEMBL • Q9VC00
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • von Willebrand factor, type C (IPR001007)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0039257 DRSC - Results from RNAi screens. • FBgn0039257 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039257 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG13648-RA GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42990
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	CG13648 (Syed et al., 2008, Fraichard et al., 2006, Fraichard et al., 2010) Mur96B (Syed et al., 2008) tnc (Syed et al., 2008, Fraichard et al., 2010, Wasbrough et al., 2010, Japanese National Institute of Genetics, 2012.5.21, Syed et al., 2012) Tnc (Fraichard et al., 2006)
Name Synonym	Mucin related 96B (Syed et al., 2008) tenectin (Bouge, 2005.9.8, Bouge et al., 2005, Fraichard et al., 2010) Tenectin (Syed et al., 2008, Fraichard et al., 2006)
Secondary FlyBase IDs
References ( 16 )
Research paper	Syed et al., 2012, PLoS Genet. 8(8): e1002850 A Luminal Glycoprotein Drives Dose-Dependent Diameter Expansion of the Drosophila melanogaster Hindgut Tube. [FBrf0219128] Fraichard et al., 2010, Dev. Biol. 340(2): 504--517 Tenectin is a novel alphaPS2betaPS integrin ligand required for wing morphogenesis and male genital looping in Drosophila. [FBrf0210522] Syed et al., 2008, PLoS ONE 3(8): e3041 A potential role for Drosophila mucins in development and physiology. [FBrf0205867] Fraichard et al., 2006, Gene Expr. Patterns 6(8): 772--776 Tenectin, a novel extracellular matrix protein expressed during Drosophila melanogaster embryonic development. [FBrf0194070]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Wasbrough et al., 2010, J. Proteomics 73(11): Supplemental Table 1. Mass spectrometry data. [FBrf0213252] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Review	Broadie et al., 2011, Dev. Neurobiol. 71(11): 1102--1130 Extracellular matrix and its receptors in drosophila neural development. [FBrf0216377]
Personal communication to FlyBase	Bellen, 2007.10.30, batch763.xml batch763.xml [FBrf0200261] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Bouge, 2005.9.8, Helping FlyBase: EDRC-OG12. Helping FlyBase: EDRC-OG12. [FBrf0188686] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]
Abstract	Bouge et al., 2005, Europ. Dros. Res. Conf. 19: OG12 Tenectin, a new ligand of alphaPS2 betaPS integrin. [FBrf0184803]
FlyBase analysis	FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]
Stock list	Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY. RNAi stocks available from NIG-FLY. [FBrf0218457]
Curated genome annotation	FamiliarityBreedsContempt, 1999.11, [Automatic annotations performed at the Celera Jamboreee.] [Automatic annotations performed at the Celera Jamboreee.] [FBrf0126705]