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Gene Dmel\danr

General Information
Symbol	Dmel\danr	Species	D. melanogaster
Name	distal antenna-related	Annotation symbol	CG13651
Feature type	protein_coding_gene	FlyBase ID	FBgn0039283
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	96C2-96C2	Sequence location	3R:20,963,799..20,965,625 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene distal antenna-related is referred to in FlyBase by the symbol Dmel\danr (CG13651, FBgn0039283). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: sequence-specific DNA binding transcription factor activity; protein binding. There is experimental evidence that it is involved in the biological process: segment specification; regulation of transcription, DNA-dependent; compound eye development; central nervous system formation. 9 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; adult segment; external compound sense organ; organ system; appendage segment; adult; extended germ band embryo; non-connected developing system; thoracic segment; sense organ. It has one annotated transcript and one annotated polypeptide. Protein features are: DNA binding HTH domain, Psq-type; Homeodomain-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system. Comments on Affy2 ProbeSet: ProbeSet 1624225_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of danr. Gene sequence location is 3R:20963799..20965625.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02	Controlled Vocabulary Terms 20-80% egg length early extended germ band stage anterior ventral neurectoderm organism
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 96C2-96C2   Limits computationally determined from genome sequence between P{lacW}OstStt3j2D9 and P{PZ}Aats-gln05461
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\danr for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.49
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) danr-RA FBtr0084780  NM_143086   1827   419
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein danr-PA   FBpp0084155   45.3   419   5.67     NP_651343   AAF56408
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Homeodomain-like (IPR009057) DNA binding HTH domain, Psq-type (IPR007889)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF56408   AY084187 AAL89925   BI358397   BI366636   BI565515   BI567058   BI578416   BI581858   BI581932   BI582191   BI605544   BI619845   BI622093   BI625941   BI629810   BQ103297   CK657876   CK657879   CO186224   CO264027   CO265442   CO297266   CO297504   CO312055   EC073845   EC079903   EC198840   EC201897   EC221214   GH741546   GH741956   GH745800   GH747264   GH766729   GH767716   GH769839
UniProtKB/Swiss-Prot	Q9VBW9
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 4 -- 6   anlage in statu nascendi   (Fisher et al., 2012) central brain anlage in statu nascendi   (Fisher et al., 2012) dorsal ectoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi ectoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi mesectoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi mesoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi ventral ectoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi visual anlage in statu nascendi   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage in statu nascendi antennal anlage in statu nascendi   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage in statu nascendi dorsal head epidermis anlage in statu nascendi   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage in statu nascendi embryonic stage 5   organism | 20-80% egg length & dorso-lateral   (Suzanne, 2004) organism | anterior & dorsal & restricted   (Suzanne, 2004) Comment:anterior-dorsal cap embryonic stage 7 -- 8   antennal anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage central brain anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage dorsal head epidermis anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage visual anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage dorsal ectoderm   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) embryonic stage 8 -- 11   ventral neurectoderm   (Suzanne, 2004) embryonic stage 9 -- 10   antennal primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium central brain primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium visual primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium dorsal head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium lateral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium ventral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 11 -- 12   central brain primordium   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 11 -- 15   ventral nerve cord   (Suzanne, 2004) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic/larval nervous system   (Fisher et al., 2012) ventral midline   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) third instar larval stage   eye disc | restricted   (Suzanne et al., 2003) antennal disc | central & restricted   (Suzanne et al., 2003) pupal stage | early   eye-antennal disc | restricted   (Suzanne et al., 2003)
Additional Descriptive Data
	Expression of the dan and danr transcripts in imaginal discs is restricted to the eye and antennal discs. Expression is strong anterior to the morphogenetic furrow with weaker expression posterior to the furrow. Strong signal is also observed in a ring corresponding to the region of the third antennal segment and in the central region of the antennal primordia. This expression pattern persists in early pupae. (Suzanne et al., 2003) danr transcript is undetectable in embryos through the syncytial blastoderm stage, suggesting that it is not maternally supplied. In stage 5 embryos danr transcript is expressed uniformly, except in the terminal regions, and in the ventral part of the embryo corresponding to the mesoderm anlage. There is also a dorsal cap of expression at the anterior of the stage 5 embryo. Expression becomes ventralized at stage 8, concentrating in the ventral neurectoderm and decreasing in the lateral ectoderm. Expression is confined to the ventral nerve cord from embryonic stage 11-15. (Suzanne, 2004)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
nucleus inferred from direct assay (Emerald et al., 2003)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    305.525 Larval Midgut    3.5 Larval Hindgut    3 Larval Malpighian Tubules    2.1 Larval Fat Body    4.2 Larval Salivary Gland    6.7 Larval Trachea    1.45 Larval Carcass    3.925 Adult Head    48 Adult Eye    60.775 Adult Brain    190.2 Adult Thoracic-Abdominal Ganglion    141.3 Adult Crop    2.2 Adult Midgut    9.1 Adult Hindgut    2.8 Adult Malpighian Tubules    20.3 Adult Fat Body    11.7 Adult Salivary Gland    8.1 Adult Heart    2.425 Adult VirginFemale Spermatheca    6.9 Adult InseminatedFemale Spermatheca    6.7 Adult Ovary    0.8 Adult Testis    2 Adult Male Accessory Gland    2.9 Adult Carcass    3.6 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    305.525 Larval Midgut    3.5 Larval Hindgut    3 Larval Malpighian Tubules    2.1 Larval Fat Body    4.2 Larval Salivary Gland    6.7 Larval Trachea    1.45 Larval Carcass    3.925 Adult Head    48 Adult Eye    60.775 Adult Brain    190.2 Adult Thoracic-Abdominal Ganglion    141.3 Adult Crop    2.2 Adult Midgut    9.1 Adult Hindgut    2.8 Adult Malpighian Tubules    20.3 Adult Fat Body    11.7 Adult Salivary Gland    8.1 Adult Heart    2.425 Adult VirginFemale Spermatheca    6.9 Adult InseminatedFemale Spermatheca    6.7 Adult Ovary    0.8 Adult Testis    2 Adult Male Accessory Gland    2.9 Adult Carcass    3.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    305.525 Larval Midgut    3.5 Larval Hindgut    3 Larval Malpighian Tubules    2.1 Larval Fat Body    4.2 Larval Salivary Gland    6.7 Larval Trachea    1.45 Larval Carcass    3.925 Adult Head    48 Adult Eye    60.775 Adult Brain    190.2 Adult Thoracic-Abdominal Ganglion    141.3 Adult Crop    2.2 Adult Midgut    9.1 Adult Hindgut    2.8 Adult Malpighian Tubules    20.3 Adult Fat Body    11.7 Adult Salivary Gland    8.1 Adult Heart    2.425 Adult VirginFemale Spermatheca    6.9 Adult InseminatedFemale Spermatheca    6.7 Adult Ovary    0.8 Adult Testis    2 Adult Male Accessory Gland    2.9 Adult Carcass    3.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    305.525 Larval Midgut    3.5 Larval Hindgut    3 Larval Malpighian Tubules    2.1 Larval Fat Body    4.2 Larval Salivary Gland    6.7 Larval Trachea    1.45 Larval Carcass    3.925 Adult Head    48 Adult Eye    60.775 Adult Brain    190.2 Adult Thoracic-Abdominal Ganglion    141.3 Adult Crop    2.2 Adult Midgut    9.1 Adult Hindgut    2.8 Adult Malpighian Tubules    20.3 Adult Fat Body    11.7 Adult Salivary Gland    8.1 Adult Heart    2.425 Adult VirginFemale Spermatheca    6.9 Adult InseminatedFemale Spermatheca    6.7 Adult Ovary    0.8 Adult Testis    2 Adult Male Accessory Gland    2.9 Adult Carcass    3.6 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    305.525 Larval Midgut    3.5 Larval Hindgut    3 Larval Malpighian Tubules    2.1 Larval Fat Body    4.2 Larval Salivary Gland    6.7 Larval Trachea    1.45 Larval Carcass    3.925 Adult Head    48 Adult Eye    60.775 Adult Brain    190.2 Adult Thoracic-Abdominal Ganglion    141.3 Adult Crop    2.2 Adult Midgut    9.1 Adult Hindgut    2.8 Adult Malpighian Tubules    20.3 Adult Fat Body    11.7 Adult Salivary Gland    8.1 Adult Heart    2.425 Adult VirginFemale Spermatheca    6.9 Adult InseminatedFemale Spermatheca    6.7 Adult Ovary    0.8 Adult Testis    2 Adult Male Accessory Gland    2.9 Adult Carcass    3.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    305.525 Larval Midgut    3.5 Larval Hindgut    3 Larval Malpighian Tubules    2.1 Larval Fat Body    4.2 Larval Salivary Gland    6.7 Larval Trachea    1.45 Larval Carcass    3.925 Adult Head    48 Adult Eye    60.775 Adult Brain    190.2 Adult Thoracic-Abdominal Ganglion    141.3 Adult Crop    2.2 Adult Midgut    9.1 Adult Hindgut    2.8 Adult Malpighian Tubules    20.3 Adult Fat Body    11.7 Adult Salivary Gland    8.1 Adult Heart    2.425 Adult VirginFemale Spermatheca    6.9 Adult InseminatedFemale Spermatheca    6.7 Adult Ovary    0.8 Adult Testis    2 Adult Male Accessory Gland    2.9 Adult Carcass    3.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    305.525 Larval Midgut    3.5 Larval Hindgut    3 Larval Malpighian Tubules    2.1 Larval Fat Body    4.2 Larval Salivary Gland    6.7 Larval Trachea    1.45 Larval Carcass    3.925 Adult Head    48 Adult Eye    60.775 Adult Brain    190.2 Adult Thoracic-Abdominal Ganglion    141.3 Adult Crop    2.2 Adult Midgut    9.1 Adult Hindgut    2.8 Adult Malpighian Tubules    20.3 Adult Fat Body    11.7 Adult Salivary Gland    8.1 Adult Heart    2.425 Adult VirginFemale Spermatheca    6.9 Adult InseminatedFemale Spermatheca    6.7 Adult Ovary    0.8 Adult Testis    2 Adult Male Accessory Gland    2.9 Adult Carcass    3.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    305.525 Larval Midgut    3.5 Larval Hindgut    3 Larval Malpighian Tubules    2.1 Larval Fat Body    4.2 Larval Salivary Gland    6.7 Larval Trachea    1.45 Larval Carcass    3.925 Adult Head    48 Adult Eye    60.775 Adult Brain    190.2 Adult Thoracic-Abdominal Ganglion    141.3 Adult Crop    2.2 Adult Midgut    9.1 Adult Hindgut    2.8 Adult Malpighian Tubules    20.3 Adult Fat Body    11.7 Adult Salivary Gland    8.1 Adult Heart    2.425 Adult VirginFemale Spermatheca    6.9 Adult InseminatedFemale Spermatheca    6.7 Adult Ovary    0.8 Adult Testis    2 Adult Male Accessory Gland    2.9 Adult Carcass    3.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    48   NA  Eye    60.775   NA  Brain    190.2   305.525  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    141.3   NA  Crop    2.2   3.5  Midgut    9.1   3  Hindgut    2.8   2.1  Malpighian Tubules    no informative data   4.2  Fat Body    no informative data   6.7  Salivary Gland    8.1   NA  Heart    2.425   1.45  Trachea    NA   NA  VirginFemale Spermatheca    6.9   NA  InseminatedFemale Spermatheca    6.7   NA  Ovary    0.8   NA  Testis    2   NA  Male Accessory Gland    2.9   3.925  Carcass    3.6 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    34 central nervous system, pupae P8    17 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    3 head, mated 1-day female    3 head, mated 4-day female    3 head, mated 20-day female    3 head, mated 1-day male    8 head, mated 4-day male    7 head, mated 20-day male    7 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    8 carcass, larvae L3 wandering    9 carcass, 1-day adult    2 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3  (34) central nervous system, pupae P8    17 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    3 head, mated 1-day female    3 head, mated 4-day female    3 head, mated 20-day female    3 head, mated 1-day male    8 head, mated 4-day male    7 head, mated 20-day male    7 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    8 carcass, larvae L3 wandering    9 carcass, 1-day adult    2 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    34 central nervous system, pupae P8    17 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    3 head, mated 1-day female    3 head, mated 4-day female    3 head, mated 20-day female    3 head, mated 1-day male    8 head, mated 4-day male    7 head, mated 20-day male    7 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    8 carcass, larvae L3 wandering    9 carcass, 1-day adult    2 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    34 central nervous system, pupae P8    17 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    3 head, mated 1-day female    3 head, mated 4-day female    3 head, mated 20-day female    3 head, mated 1-day male    8 head, mated 4-day male    7 head, mated 20-day male    7 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    8 carcass, larvae L3 wandering    9 carcass, 1-day adult    2 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    34 central nervous system, pupae P8    17 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    3 head, mated 1-day female    3 head, mated 4-day female    3 head, mated 20-day female    3 head, mated 1-day male    8 head, mated 4-day male    7 head, mated 20-day male    7 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    8 carcass, larvae L3 wandering    9 carcass, 1-day adult    2 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3  (34) central nervous system, pupae P8    17 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    3 head, mated 1-day female    3 head, mated 4-day female    3 head, mated 20-day female    3 head, mated 1-day male    8 head, mated 4-day male    7 head, mated 20-day male    7 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    8 carcass, larvae L3 wandering    9 carcass, 1-day adult    2 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    34 central nervous system, pupae P8    17 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    3 head, mated 1-day female    3 head, mated 4-day female    3 head, mated 20-day female    3 head, mated 1-day male    8 head, mated 4-day male    7 head, mated 20-day male    7 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    8 carcass, larvae L3 wandering    9 carcass, 1-day adult    2 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    34 central nervous system, pupae P8    17 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    3 head, mated 1-day female    3 head, mated 4-day female    3 head, mated 20-day female    3 head, mated 1-day male    8 head, mated 4-day male    7 head, mated 20-day male    7 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    8 carcass, larvae L3 wandering    9 carcass, 1-day adult    2 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    50 embryo 04-06hr    32 embryo 06-08hr    7 embryo 08-10hr    7 embryo 10-12hr    13 embryo 12-14hr    9 embryo 14-16hr    9 embryo 16-18hr    7 embryo 18-20hr    10 embryo 20-22hr    7 embryo 22-24hr    6 larva L1    5 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    4 white prepupae new    5 white prepupae 12hr    8 white prepupae 24hr    7 pupae 2d postWPP    4 pupae 3d postWPP    1 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    1 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr  (50) embryo 04-06hr  (32) embryo 06-08hr    7 embryo 08-10hr    7 embryo 10-12hr    13 embryo 12-14hr    9 embryo 14-16hr    9 embryo 16-18hr    7 embryo 18-20hr    10 embryo 20-22hr    7 embryo 22-24hr    6 larva L1    5 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    4 white prepupae new    5 white prepupae 12hr    8 white prepupae 24hr    7 pupae 2d postWPP    4 pupae 3d postWPP    1 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    1 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    50 embryo 04-06hr    32 embryo 06-08hr    7 embryo 08-10hr    7 embryo 10-12hr    13 embryo 12-14hr    9 embryo 14-16hr    9 embryo 16-18hr    7 embryo 18-20hr    10 embryo 20-22hr    7 embryo 22-24hr    6 larva L1    5 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    4 white prepupae new    5 white prepupae 12hr    8 white prepupae 24hr    7 pupae 2d postWPP    4 pupae 3d postWPP    1 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    1 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    50 embryo 04-06hr    32 embryo 06-08hr    7 embryo 08-10hr    7 embryo 10-12hr    13 embryo 12-14hr    9 embryo 14-16hr    9 embryo 16-18hr    7 embryo 18-20hr    10 embryo 20-22hr    7 embryo 22-24hr    6 larva L1    5 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    4 white prepupae new    5 white prepupae 12hr    8 white prepupae 24hr    7 pupae 2d postWPP    4 pupae 3d postWPP    1 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    1 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    50 embryo 04-06hr    32 embryo 06-08hr    7 embryo 08-10hr    7 embryo 10-12hr    13 embryo 12-14hr    9 embryo 14-16hr    9 embryo 16-18hr    7 embryo 18-20hr    10 embryo 20-22hr    7 embryo 22-24hr    6 larva L1    5 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    4 white prepupae new    5 white prepupae 12hr    8 white prepupae 24hr    7 pupae 2d postWPP    4 pupae 3d postWPP    1 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    1 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr  (50) embryo 04-06hr  32 embryo 06-08hr    7 embryo 08-10hr    7 embryo 10-12hr    13 embryo 12-14hr    9 embryo 14-16hr    9 embryo 16-18hr    7 embryo 18-20hr    10 embryo 20-22hr    7 embryo 22-24hr    6 larva L1    5 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    4 white prepupae new    5 white prepupae 12hr    8 white prepupae 24hr    7 pupae 2d postWPP    4 pupae 3d postWPP    1 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    1 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    50 embryo 04-06hr    32 embryo 06-08hr    7 embryo 08-10hr    7 embryo 10-12hr    13 embryo 12-14hr    9 embryo 14-16hr    9 embryo 16-18hr    7 embryo 18-20hr    10 embryo 20-22hr    7 embryo 22-24hr    6 larva L1    5 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    4 white prepupae new    5 white prepupae 12hr    8 white prepupae 24hr    7 pupae 2d postWPP    4 pupae 3d postWPP    1 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    1 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    50 embryo 04-06hr    32 embryo 06-08hr    7 embryo 08-10hr    7 embryo 10-12hr    13 embryo 12-14hr    9 embryo 14-16hr    9 embryo 16-18hr    7 embryo 18-20hr    10 embryo 20-22hr    7 embryo 22-24hr    6 larva L1    5 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    4 white prepupae new    5 white prepupae 12hr    8 white prepupae 24hr    7 pupae 2d postWPP    4 pupae 3d postWPP    1 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    1 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_11 mE1_20_mRNA_expression_cluster_06
External Data & Images
Linkouts	BDGP expression data • RE72284 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039283 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG13651-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for danr Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4Dll-md23 danrScer\UAS.cEa viable danrex35 viable, with Scer\GAL4pnr-MD237 danrGD4597 Other Phenotypes Allele neuroanatomy defective, with Scer\GAL4nos.UTR.T:Hsim\VP16 danrdsRNA.Scer\UAS visible danrex35 visible, with Scer\GAL4Dll-md23 danrEPg35635 visible, with Scer\GAL4dpp.blk1 danrScer\UAS.cEa Phenotype manifest in Allele antenna | distal | ectopic, with Scer\GAL4dpp.blk1 danrScer\UAS.cEa antennal segment 3 & macrochaeta | ectopic, with Scer\GAL4Dll-md23 danrdsRNA.Scer\UAS arista, with Scer\GAL4Dll-md23 danrdsRNA.Scer\UAS arista | ectopic, with Scer\GAL4dpp.blk1 danrScer\UAS.cEa basal cylinder | somatic clone danrex35 bract | ectopic | somatic clone danrex35 eye, with Scer\GAL4GMR.PS danrdsRNA.Scer\UAS eye | ectopic, with Scer\GAL4Dll-md23 danrScer\UAS.cSa germ band, with Scer\GAL4nos.UTR.T:Hsim\VP16 danrdsRNA.Scer\UAS interommatidial bristle, with Scer\GAL4GMR.PS danrdsRNA.Scer\UAS leg | distal, with Scer\GAL4dpp.blk1 danrScer\UAS.cEa ommatidium, with Scer\GAL4GMR.PS danrdsRNA.Scer\UAS presumptive embryonic/larval nervous system, with Scer\GAL4nos.UTR.T:Hsim\VP16 danrdsRNA.Scer\UAS rostral membrane, with Scer\GAL4Dll-md23 danrScer\UAS.cSa tarsal segment, with Scer\GAL4Dll-md23 danrEPg35635 third segment of antenna danrex35 third segment of antenna, with Scer\GAL4Dll-md23 danrScer\UAS.cSa danrdsRNA.Scer\UAS unguis, with Scer\GAL4dpp.blk1 danrScer\UAS.cEa ventral nerve cord, with Scer\GAL4nos.UTR.T:Hsim\VP16 danrdsRNA.Scer\UAS wing, with Scer\GAL4ptc-559.1 danrScer\UAS.cSa wing margin bristle | ectopic, with Scer\GAL4ptc-559.1 danrScer\UAS.cSa
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of danr Class Mutagen Stocks Known lesion danrG18430 P-element activity 1 -- danrEPg35635 P-element activity 0 Yes danrex35 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of danr Class Mutagen Stocks Known lesion danrGD4597 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes danrJF03015 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes danrdsRNA.Scer\UAS in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes danrNIG.13651R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes danrScer\UAS.cEa in vitro construct - regulatory fusion 0 Yes danrScer\UAS.cSa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6201 (Ryder, 2004.4.26, Yang et al., 2011)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4597} NA P{NIG.13651R} NA P{TRiP.JF03015} NA P{UAS-danr.E} NA P{UAS-danr.RNAi} NA P{UAS-danr.S} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{GT1}BG01545 NA insertion of mobile activating element P{EP}danrG18430 NA P{EPg}danrEPg35635 NA insertion of enhancer trap binary system P{GawB}CES75 No P{GawB}MD634 No
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 7 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with UniProtKB:O18381 (assigned by UniProtKB) (Curtiss et al., 2007) inferred from physical interaction with UniProtKB:Q9VBW6 (assigned by UniProtKB) (Curtiss et al., 2007) inferred from physical interaction with UniProtKB:Q24027 (assigned by UniProtKB) (Curtiss et al., 2007) sequence-specific DNA binding transcription factor activity inferred from mutant phenotype (assigned by UniProtKB) (Curtiss et al., 2007)
Biological Process
CV term Evidence References
central nervous system formation inferred from mutant phenotype (Suzanne, 2004) compound eye development inferred from mutant phenotype (assigned by UniProtKB) (Curtiss et al., 2007) regulation of transcription, DNA-dependent inferred from mutant phenotype (assigned by UniProtKB) (Curtiss et al., 2007) segment specification inferred from mutant phenotype (assigned by UniProtKB) (Curtiss et al., 2007)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Emerald et al., 2003)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function
CV term Evidence References
DNA binding inferred from electronic annotation with InterPro:IPR006695, InterPro:IPR011526, InterPro:IPR012287 (FlyBase Curators et al., 2004-) non-traceable author statement (Lehmann, 2002.7.1)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
danr - CG3817 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) danr - CG4553 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) danr - CtBP pull down, western blot (Hoang et al., 2010) danr - dan pull down, western blot, anti bait coimmunoprecipitation (Hoang et al., 2010)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions danr allele Gene References danrdsRNA.Scer\UAS dan (Suzanne et al., 2003) unspecified ss (Emerald et al., 2003)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67940 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0039283 DroID - A comprehensive database of gene and protein interactions. • FBgn0039283 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43020
Orthologs
OrthoDB Orthologs (29) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6WSWWG Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search EOG6JQ2T6 Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6WSWWG)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\danr     Drosophila simulans   Dsim\GD21179 Y   Drosophila sechellia   Dsec\GM17808 Y   Drosophila erecta   Dere\GG11367 Y   Drosophila yakuba   Dyak\GE23564 Y   Drosophila ananassae   Dana\GF17893 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA12437 Y   Drosophila persimilis   Dper\GL21906 Y   Drosophila willistoni   Dwil\GK13890 Y   Drosophila virilis   Dvir\GJ23601 Y   Drosophila mojavensis   Dmoj\GI23730 Y   Drosophila grimshawi   Dgri\GH18050 Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (EOG6JQ2T6)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC100578718 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG003549 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH26606 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH15692 Y Atta cephalotes Leafcutter ant  Acep\ACEP14880 Y Atta cephalotes Leafcutter ant  Acep\ACEP15389 Y Atta cephalotes Leafcutter ant  Acep\ACEP19043 Y Atta cephalotes Leafcutter ant  Acep\ACEP15071 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO19072 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL14715 Y Linepithema humile Argentine ant  Lhum\LH12002 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB12106 Y Solenopsis invicta Red fire ant  Sinv\SINV11783 Y Solenopsis invicta Red fire ant  Sinv\SINV18658 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI37082 Y Bombyx mori Silkmoth  Bmor\BGIBMGA004818 Y Tribolium castaneum Red flour beetle  Tcas\dan Y
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD21179 Drosophila sechellia Dsec\GM17808 Drosophila erecta Dere\GG11367 Drosophila yakuba Dyak\GE23564 Drosophila ananassae Dana\GF17893 Drosophila pseudoobscura pseudoobscura Dpse\GA12437 Drosophila persimilis Dper\GL21906 Drosophila willistoni Dwil\GK13890 Drosophila virilis Dvir\GJ23601 Drosophila mojavensis Dmoj\GI23730 Drosophila grimshawi Dgri\GH18050
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	32030 w1118; P{EP}danrG18430 28378 y1 v1; P{TRiP.JF03015}attP2
VDRC	v11514 w1118; P{GD4597}v11514 v11515 w1118; P{GD4597}v11515
Genomic Clones ( 1 )
	BACR17E12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 35 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE72284
Other clones	DPiM_RE72284
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE29109 RE29112 RE45157 RE52218 RH19671 RH19771 RH20143 RH36889 RH50968 RH53913 RH58726 RH63295 RH66453 RH71188
Other clones	29394 31989 52943 83236 CK01.17C.H12 EK017162 EK137221 EK142659 EK169955 EK216520 EK227802 RP001028893 RP001030613 RP001050941 RP001051270 RP001051327 RP001053143 RP001055708 UUGC0700
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0039283 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43020
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: danr CG13651 (Curtiss, 2003.2.10)
Source for database merge of
Additional comments
Other Comments
	danr encodes a protein containing a single "Pipsqueak motif". (Curtiss et al., 2003) danr may have a role in eye development. (Curtiss et al., 2003) Mutants simultaneously convert antennal to eye tissue, and distal leg to distal antennal structures. (Curtiss et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_143086 RefSeq (Proteins) • NP_651343 DDBJ / EMBL / GenBank • AAF56408 AAL89925 AY084187 BI578416 Entrez Gene - A searchable database of RefSeq genes. • 43020 UniProtKB/Swiss-Prot • Q9VBW9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Homeodomain-like (IPR009057) DNA binding HTH domain, Psq-type (IPR007889) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE72284
Linkouts
	BioGRID - A database of protein and genetic interactions • 67940 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0039283 DroID - A comprehensive database of gene and protein interactions. • FBgn0039283 DRSC - Results from RNAi screens. • FBgn0039283 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039283 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG13651-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0039283 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43020 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /sturtevant/dandanr1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43020 modMine - Data generated by the modENCODE project. • FBgn0039283
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	CG13651 (Suzanne et al., 2003, Michaut et al., 2003, Siegmund and Lehmann, 2002, Giot et al., 2003, Datta et al., 2011, Peng et al., 2007, Perkins et al., 2009) danr (Burnett et al., 2007, Suzanne et al., 2003, Wong et al., 2005, Suzanne, 2004, Kohwi et al., 2011, Datta et al., 2011, Bao and Friedrich, 2009, Curtiss et al., 2007, Japanese National Institute of Genetics, 2012.5.21, Nfonsam et al., 2012, Hou et al., 2009) Danr (Burnett et al., 2007) hern (Suzanne, 2004)
Name Synonym	Distal antenna related (Kuzin et al., 2005, Burnett et al., 2007) distal antenna-related (Emerald et al., 2003, Kohwi et al., 2011, Curtiss et al., 2007) distal antenna related (Suzanne, 2004, Bao and Friedrich, 2009) hernandez (Suzanne et al., 2003, Suzanne, 2004) Tintin (Suzanne et al., 2003)
Secondary FlyBase IDs
References ( 39 )
Generate a list of	All references relating to this gene ( 39 )
List References by type	Research paper  ( 17 ) Supplementary material  ( 4 ) Review  ( 1 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 3 ) FlyBase analysis  ( 1 ) Stock list  ( 1 ) Website  ( 1 )
Recent research papers ( 4 )
	Nfonsam et al., 2012, PLoS ONE 7(8): e44583 Analysis of the Transcriptomes Downstream of Eyeless and the Hedgehog, Decapentaplegic and Notch Signaling Pathways in Drosophila melanogaster. [FBrf0219414] Datta et al., 2011, Evol. Dev. 13(1): 58--71 Differential selection within the Drosophila retinal determination network and evidence for functional divergence between paralog pairs. [FBrf0212714] Kohwi et al., 2011, Development 138(9): 1727--1735 The pipsqueak-domain proteins Distal antenna and Distal antenna-related restrict Hunchback neuroblast expression and early-born neuronal identity. [FBrf0213466] Yang et al., 2011, Mol. Biol. Cell 22(7): 976--987 Regulation of flagellar motility by the conserved flagellar protein CG34110/Ccdc135/FAP50. [FBrf0214073] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...