FB2020_01, released Feb 12, 2020

Gene: Dmel\dan

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General Information
Symbol
Dmel\dan
Species
D. melanogaster
Name
distal antenna
Annotation Symbol
CG11849
Feature Type
protein_coding_gene
FlyBase ID
FBgn0039286
Gene Model Status
Current
Stock Availability
8 publicly available
Gene Snapshot
distal antenna (dan) encodes a pipsqueak-type transcription factor that functions downstream of the gene encoded by Dll. It is required for the expression of a subset of olfactory receptor genes in the antenna. [Date last reviewed: 2018-11-08]
Other Summaries
Also Known As

fernandez

Key Links
Genomic Location
Cytogenetic map
96C3-96C4
Sequence location
3R:25,184,383..25,192,806 [+]
Recombination map

3-87

RefSeq locus
NT_033777 REGION:25184383..25192806
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
DNA-binding transcription factor activity; protein binding
Predictions / Assertions
DNA binding
Summaries
Gene Group (FlyBase)
PIPSQUEAK TRANSCRIPTION FACTORS -
Pipsqueak transcription factors are sequence-specific DNA binding proteins that regulate transcription. These family members are characterized by a heix-turn-helix DNA-binding domain called Psq domain, which consists of four tandem repeats of a conserved 50-amino acid sequence, the Psq motif. (Adapted from FBrf0148954 and FBrf0105267).
Protein Function (UniProtKB)
Probable transcription factor with a role in the retinal determination (RD) network. Regulates ato expression and is required for normal R8 induction and differentiation. Danr appears to repress Dan expression, but Dan is required for Danr expression anterior to the morphogenetic furrow (MF). Dan and Danr lie downstream of so and require dac function for highest levels of expression. Contributes to differentiation of antenna-specific characteristics; effector gene that acts downstream of homothorax (hth), Distal-less (Dll), cut (ct) and spineless (ss) genes to control differentiation of distal antennal structures.
(UniProt, Q9VBW6)
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
2

Please see the GBrowse view of Dmel\dan or the JBrowse view of Dmel\dan for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.44

gene_with_stop_codon_read_through ; SO:0000697

Stop-codon suppression (UAG) postulated; FBrf0216884.

Gene model reviewed during 5.49

Sequence Ontology: Class of Gene
gene_with_stop_codon_read_through
(Jungreis et al., 2011)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
dan-RA
FBtr0084803
NM_143089
3340
678
dan-RB
FBtr0330288
NM_001276019
3340
781
dan-RC
FBtr0330289
NM_001276020
3968
678
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
dan-PA
FBpp0084178
71.9
678
5.90
NP_651346
AAF56411
dan-PB
FBpp0303320
82.9
781
4.79
NP_001262948
AGB96328
dan-PC
FBpp0303321
71.9
678
5.90
NP_001262949
AGB96329
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

678 aa isoforms: dan-PA, dan-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Homomers. Interacts with itself, danr, ey and dac to form a complex (or complexes) containing the RD factors.

(UniProt, Q9VBW6)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\dan using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (9 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
DNA-binding transcription factor activity
inferred from mutant phenotype
(assigned by UniProt )
(Curtiss et al., 2007)
protein binding
inferred from physical interaction with UniProtKB:O18381
(assigned by UniProt )
(Curtiss et al., 2007)
inferred from physical interaction with UniProtKB:Q24027
(assigned by UniProt )
(Curtiss et al., 2007)
inferred from physical interaction with UniProtKB:Q9VBW9
(assigned by UniProt )
(Curtiss et al., 2007)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
DNA binding
inferred from electronic annotation with InterPro:IPR007889, InterPro:IPR009057
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Biological Process (5 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
antennal development
inferred from mutant phenotype
(assigned by UniProt )
(Emerald et al., 2003)
central nervous system formation
inferred from mutant phenotype
(Suzanne, 2004)
compound eye development
inferred from mutant phenotype
(assigned by UniProt )
(Curtiss et al., 2007)
regulation of transcription, DNA-templated
inferred from mutant phenotype
(assigned by UniProt )
(Curtiss et al., 2007)
segment specification
inferred from mutant phenotype
(assigned by UniProt )
(Curtiss et al., 2007)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
nucleus
inferred from direct assay
(Emerald et al., 2003)
Terms Based on Predictions or Assertions (0 terms)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
eye disc | restricted
(Suzanne et al., 2003)
antennal disc | central | restricted
(Suzanne et al., 2003)
embryonic stage 5
organism | 10-90% egg length | dorso-lateral
(Suzanne, 2004)
embryonic stage 8 -- 9
ventral neurectoderm
(Suzanne, 2004)
embryonic stage 9 -- 10
stage 1 neuroblast
(Suzanne, 2004)
stage 2 neuroblast
(Suzanne, 2004)
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
embryonic stage 4 -- 6
anlage in statu nascendi
(Fisher et al., 2012)
central brain anlage in statu nascendi
(Fisher et al., 2012)
dorsal ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
ventral ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
embryonic stage 7 -- 8
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal ectoderm
(Fisher et al., 2012)
lateral head epidermis
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
ventral nerve cord primordium

Comment: reported as ventral nerve cord anlage

(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
embryonic glioblast of ventral nerve cord primordium

Comment: reported as glioblasts of ventral nervous system

(Fisher et al., 2012)
embryonic neuroblast of ventral nerve cord primordium
(Fisher et al., 2012)
procephalic neuroblast
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic ganglion mother cell
(Fisher et al., 2012)
gnathal primordium
(Fisher et al., 2012)
ventral epidermis primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic central brain neuron
(Fisher et al., 2012)
ventral midline
(Fisher et al., 2012)
ventral nerve cord
(Fisher et al., 2012)
embryonic/larval nervous system
(Fisher et al., 2012)
prepupal stage
eye-antennal disc | restricted
(Suzanne et al., 2003)
Additional Descriptive Data

dan transcript is undetectable in embryos through the syncytial blastoderm stage, suggesting that it is not maternally supplied. In stage 5 embryos dan transcript is expressed uniformly, except in the terminal regions, and in the ventral part of the embryo corresponding to the mesoderm anlage. Expression becomes ventralized at stage 8, concentrating in the ventral neurectoderm and decreasing in the lateral ectoderm. Expression is confined to the ventral nerve cord from embryonic stage 11-15.

(Suzanne, 2004)

Expression of the dan and danr transcripts in imaginal discs is restricted to the eye and antennal discs. Expression is strong anterior to the morphogenetic furrow with weaker expression posterior to the furrow. Strong signal is also observed in a ring corresponding to the region of the third antennal segment and in the central region of the antennal primordia. This expression pattern persists in early pupae.

(Suzanne et al., 2003)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 5
organism | 10-90% egg length | dorso-lateral
(Suzanne, 2004)
embryonic stage 8
ventral neurectoderm

Comment: -9

(Suzanne, 2004)
embryonic stage 9 -- 10
stage 1 neuroblast
(Suzanne, 2004)
stage 2 neuroblast
(Suzanne, 2004)
embryonic stage 11 -- 15
ventral nerve cord
(Suzanne, 2004)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 5 of adulthood & male -- day 7 of adulthood & male
spermatozoon
(Wasbrough et al., 2010)
Additional Descriptive Data

dan protein is undetectable in embryos through the syncytial blastoderm stage, suggesting that it is not maternally supplied. In stage 5 embryos dan protein is expressed uniformly, except in the terminal regions, and in the ventral part of the embryo corresponding to the mesoderm anlage. Expression becomes ventralized at stage 8, concentrating in the ventral neurectoderm and decreasing in the lateral ectoderm. Expression is confined to the ventral nerve cord from embryonic stage 11-15.

(Suzanne, 2004)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
nucleus
inferred from direct assay
(Emerald et al., 2003)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\dan in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 11 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of dan
Transgenic constructs containing regulatory region of dan
Deletions and Duplications ( 1 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4da.Switch.PT
lethal, with Scer\GAL4Dll-md23
viable, with Scer\GAL4- :
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
neuroanatomy defective, with Scer\GAL4VP16.nos.UTR
visible, with Scer\GAL4- :
visible, with Scer\GAL4Dll-md23
visible, with Scer\GAL4dpp.blk1
Phenotype manifest in
Allele
antenna, with Scer\GAL4- :
antenna, with Scer\GAL4Dll-md23
antenna | distal | ectopic, with Scer\GAL4Dll-md23
antenna | distal | ectopic, with Scer\GAL4dpp.blk1
antennal segment 3 & macrochaeta | ectopic
antennal segment 3 & macrochaeta | ectopic, with Scer\GAL4Dll-md23
arista, with Scer\GAL4Dll-md23
arista | ectopic, with Scer\GAL4Dll-md23
arista | ectopic, with Scer\GAL4dpp.blk1
embryonic/larval hemocyte | third instar larval stage, with Scer\GAL4Pxn.PS
eye, with Scer\GAL4GMR.PS
eye | ectopic, with Scer\GAL4dpp.blk1
germ band, with Scer\GAL4VP16.nos.UTR
interommatidial bristle, with Scer\GAL4GMR.PS
leg | distal, with Scer\GAL4Dll-md23
leg | distal, with Scer\GAL4dpp.blk1
ommatidium, with Scer\GAL4GMR.PS
presumptive embryonic/larval nervous system, with Scer\GAL4VP16.nos.UTR
rostral membrane, with Scer\GAL4dpp.blk1
third segment of antenna, with Scer\GAL4- :
third segment of antenna, with Scer\GAL4Dll-md23
third segment of antenna, with Scer\GAL4dpp.blk1
unguis, with Scer\GAL4Dll-md23
unguis, with Scer\GAL4dpp.blk1
unguis (with danems3), with Scer\GAL4Dll-md23
unguis (with danEPgJ3-220), with Scer\GAL4Dll-md23
ventral nerve cord, with Scer\GAL4VP16.nos.UTR
wing, with Scer\GAL4dpp.blk1
wing hinge, with Scer\GAL4dpp.blk1
wing margin bristle | ectopic, with Scer\GAL4dpp.blk1
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (10)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\CENPB
1 of 15
Yes
No
Hsap\JRK
1 of 15
Yes
No
 
Hsap\JRKL
1 of 15
Yes
No
Hsap\LOC100287896
1 of 15
Yes
Yes
Hsap\TIGD1
1 of 15
Yes
No
Hsap\TIGD2
1 of 15
Yes
No
Hsap\TIGD4
1 of 15
Yes
No
Hsap\TIGD5
1 of 15
Yes
No
Hsap\TIGD6
1 of 15
Yes
No
Hsap\TIGD7
1 of 15
Yes
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (6)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Cenpb
1 of 15
Yes
No
Mmus\Jrkl
1 of 15
Yes
No
Mmus\Jrk
1 of 15
Yes
No
Mmus\Tigd2
1 of 15
Yes
No
Mmus\Tigd4
1 of 15
Yes
No
Mmus\Tigd5
1 of 15
Yes
No
Rattus norvegicus (Norway rat) (7)
Rnor\Cenpb
1 of 13
Yes
No
Rnor\Jrkl
1 of 13
Yes
No
Rnor\Jrk
1 of 13
Yes
No
Rnor\LOC108348248
1 of 13
Yes
Yes
Rnor\Tigd2
1 of 13
Yes
No
Rnor\Tigd4
1 of 13
Yes
No
Rnor\Tigd5
1 of 13
Yes
No
Xenopus tropicalis (Western clawed frog) (3)
Xtro\jrk
1 of 12
Yes
Yes
Xtro\tigd3
1 of 12
Yes
Yes
Xtro\tigd5
1 of 12
Yes
No
Danio rerio (Zebrafish) (1)
Drer\LOC100150296
1 of 15
Yes
No
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\Y48G1C.6
1 of 15
Yes
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\PDC2
1 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (3)
Spom\cbh1
1 of 12
Yes
No
Spom\cbh2
1 of 12
Yes
No
Spom\cbp1
1 of 12
Yes
No
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091904WB )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\dan
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00009667
Drosophila simulans
Dsim\GD21183
Drosophila sechellia
Dsec\GM17814
Drosophila erecta
Dere\GG11370
Drosophila yakuba
Dyak\GE23568
Drosophila ananassae
Dana\GF17896
Drosophila pseudoobscura pseudoobscura
Dpse\GA11234
Drosophila persimilis
Dper\GL21909
Drosophila willistoni
Dwil\GK13892
Drosophila virilis
Dvir\GJ23602
Drosophila mojavensis
Dmoj\GI23731
Drosophila grimshawi
Dgri\GH18053
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091506HY )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17008954
Glossina morsitans
Tsetse fly
Gmor\GMOY006899
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_09065
Mayetiola destructor
Hessian fly
Mdes\Mdes003243
Aedes aegypti
Yellow fever mosquito
Aaeg\dan
Anopheles darlingi
American malaria mosquito
Adar\ADAC007293
Anopheles gambiae
Malaria mosquito
Agam\AGAP013200
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0FBF )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA004818
Danaus plexippus
Monarch butterfly
Dple\DPOGS214934-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL015598
Apis florea
Little honeybee
Aflo\2689679252
Apis mellifera
Western honey bee
Amel\LOC100578718
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP12464
Bombus terrestris
Buff-tailed bumblebee
Bter\15216791
Linepithema humile
Argentine ant
Lhum\LH12002
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00103f
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG003549
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_13018
Tribolium castaneum
Red flour beetle
Tcas\dan
Pediculus humanus
Human body louse
Phum\PHUM514010
Cimex lectularius
Bed bug
Clec\CLEC008767
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI060982
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI088053
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI37082
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_11461
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0FAU )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Stegodyphus mimosarum
African social velvet spider
Smim\KFM57181.1
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0OJQ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000013039
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (3)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
danr
2 of 10
dany
2 of 10
cag
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement
    View in Interactions Browser
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    dan
    enhanceable
    danr
    (Suzanne et al., 2003)
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    danr
    enhanceable
    dan
    (Suzanne et al., 2003)
    hb
    enhanceable
    dan
    (Kohwi et al., 2013)
    ss
    suppressible
    dan
    (Emerald et al., 2003)
    External Data
    Subunit Structure (UniProtKB)
    Homomers. Interacts with itself, danr, ey and dac to form a complex (or complexes) containing the RD factors.
    (UniProt, Q9VBW6 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3R
    Recombination map

    3-87

    Cytogenetic map
    96C3-96C4
    Sequence location
    3R:25,184,383..25,192,806 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    96C3-96C4
    Limits computationally determined from genome sequence between P{lacW}OstStt3j2D9 and P{PZ}Aats-gln05461
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location

    3-87

    (FlyBase, 2016)

    3-85.8

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (8)
    Genomic Clones (21)
    cDNA Clones (42)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
       
      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of

      Source for identity of: dan CG11849

      (Curtiss, 2003.2.10)
      Source for database merge of
      Additional comments
      Other Comments

      danr encodes a protein containing a single "Pipsqueak motif".

      (Curtiss et al., 2003)

      dan may have a role in eye development.

      (Curtiss et al., 2003)

      Mutants simultaneously convert antennal to eye tissue, and distal leg to distal antennal structures.

      (Curtiss et al., 2003)
      Origin and Etymology
      Discoverer
      Etymology
      Identification
      External Crossreferences and Linkouts ( 41 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
      InterPro - A database of protein families, domains and functional sites
      KEGG Genes - Molecular building blocks of life in the genomic space.
      modMine - A data warehouse for the modENCODE project
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
      FlyMine - An integrated database for Drosophila genomics
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Synonyms and Secondary IDs (7)
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      References (72)