Gene Dmel\Cad96Cb

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General Information

Symbol

Dmel\Cad96Cb

Species

D. melanogaster

Name

Cadherin 96Cb

Annotation symbol

CG13664

Feature type

protein_coding_gene

FlyBase ID

FBgn0039294

Gene Model Status

Current

Stock availability

9 publicly available

Also Known As

CG10421, cad96C

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

96C7-96C7

Sequence location

3R:21,049,878..21,058,043 [-]

Genomic Maps

Select View:

Summary Information

Automatically generated summary

See sections below for more information

The gene Cadherin 96Cb is referred to in FlyBase by the symbol Dmel\Cad96Cb (CG13664, FBgn0039294). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: calcium ion binding. There is experimental evidence that it is involved in the biological process: open tracheal system development. 9 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Cadherin; Cadherin conserved site; Cadherin-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 06-18 hour embryonic stages, during late pupal stages. Summary of FlyAtlas Anatomical Expression Data: No expression detected in any larval or adult organs/tissues. Gene sequence location is 3R:21049878..21058043.

User Contributed Data

Beta version, feedback welcome

Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

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FB2013_03

FB2013_02

All updates

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Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

96C7-96C7

Limits computationally determined from genome sequence between P{lacW}OstStt3^j2D9 and P{PZ}Aats-gln⁰⁵⁴⁶¹

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Gene Model & Products

Please see the GBrowse view of Dmel\Cad96Cb for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Comments on Gene Model

Gene model reviewed during 5.49

Gene merge based on protein alignment (BLASTX) data

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

Cad96Cb-RB

FBtr0301090

NM_143098

3016

786

Cad96Cb-RC

FBtr0302299

NM_001170256

2991

785

Cad96Cb-RD

FBtr0339260

3003

789

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

Cad96Cb-PB

FBpp0290312

85.5

786

6.01

NP_651355

AAF56421

Cad96Cb-PC

FBpp0291505

85.3

785

6.01

NP_001163727

ACZ95021

Cad96Cb-PD

FBpp0308367

85.8

789

6.01

Additional Polypeptide Data & Comments

Reported size (kDa)

Comments

External Data

Linkouts

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Cadherin (IPR002126)

Cadherin-like (IPR015919)

Cadherin conserved site (IPR020894)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Mapped Features

Mapped Features have been reorganized, please see this article for details.

Additional mapped features and mutations can be found on GBrowse or related reports.

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization (GO Cellular Component)

CV term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

Reference

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

FlyAtlas Anatomy Microarray

FlyAtlas Anatomical Expression Data

(FlyAtlas-RNA.adult)

(FlyAtlas-RNA.larva)

	Styles
	Linear
	Logarithmic
	Heatmap
	Back-to-back
	Scales
	gene max expression
	Moderate expression bin max
	High level expression bin max
	Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: No expression detected in any larval or adult organs/tissues.
[download data (TSV)]

Guide to FlyAtlas expression level colors
	No expression (0 - 9.999)
	Low expression (10 - 99.999)
	Moderate expression (100 - 499.999)
	High level expression (500 - 999.999)
	Very high expression (>999.999)

Heatmap
Tissue		Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass

FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)

modENCODE Anatomy RNA-Seq

modENCODE Tissue Expression Data

(modENCODE_mRNA-Seq_tissues)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		1
central nervous system, larvae L3		1
central nervous system, pupae P8		3
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		0
head, mated 4-day female		0
head, mated 20-day female		0
head, mated 1-day male		0
head, mated 4-day male		0
head, mated 20-day male		0
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		0
digestive system, 20-day adult		0
fat body, larvae L3 wandering		0
fat body, white prepupae		0
fat body, pupae P8		6
carcass, larvae L3 wandering		1
carcass, 1-day adult		0
carcass, 4-day adult		0
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		0
accessory gland, mated 4-day male		0
Expression Level Scale		Very low Low Moderate

Linear, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		1
central nervous system, larvae L3		1
central nervous system, pupae P8		3
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		0
head, mated 4-day female		0
head, mated 20-day female		0
head, mated 1-day male		0
head, mated 4-day male		0
head, mated 20-day male		0
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		0
digestive system, 20-day adult		0
fat body, larvae L3 wandering		0
fat body, white prepupae		0
fat body, pupae P8		6
carcass, larvae L3 wandering		1
carcass, 1-day adult		0
carcass, 4-day adult		0
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		0
accessory gland, mated 4-day male		0
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		1
central nervous system, larvae L3		1
central nervous system, pupae P8		3
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		0
head, mated 4-day female		0
head, mated 20-day female		0
head, mated 1-day male		0
head, mated 4-day male		0
head, mated 20-day male		0
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		0
digestive system, 20-day adult		0
fat body, larvae L3 wandering		0
fat body, white prepupae		0
fat body, pupae P8		6
carcass, larvae L3 wandering		1
carcass, 1-day adult		0
carcass, 4-day adult		0
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		0
accessory gland, mated 4-day male		0
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		1
central nervous system, larvae L3		1
central nervous system, pupae P8		3
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		0
head, mated 4-day female		0
head, mated 20-day female		0
head, mated 1-day male		0
head, mated 4-day male		0
head, mated 20-day male		0
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		0
digestive system, 20-day adult		0
fat body, larvae L3 wandering		0
fat body, white prepupae		0
fat body, pupae P8		6
carcass, larvae L3 wandering		1
carcass, 1-day adult		0
carcass, 4-day adult		0
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		0
accessory gland, mated 4-day male		0
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		1
central nervous system, larvae L3		1
central nervous system, pupae P8		3
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		0
head, mated 4-day female		0
head, mated 20-day female		0
head, mated 1-day male		0
head, mated 4-day male		0
head, mated 20-day male		0
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		0
digestive system, 20-day adult		0
fat body, larvae L3 wandering		0
fat body, white prepupae		0
fat body, pupae P8		6
carcass, larvae L3 wandering		1
carcass, 1-day adult		0
carcass, 4-day adult		0
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		0
accessory gland, mated 4-day male		0
Expression Level Scale		Very low Low Moderate

log, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		1
central nervous system, larvae L3		1
central nervous system, pupae P8		3
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		0
head, mated 4-day female		0
head, mated 20-day female		0
head, mated 1-day male		0
head, mated 4-day male		0
head, mated 20-day male		0
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		0
digestive system, 20-day adult		0
fat body, larvae L3 wandering		0
fat body, white prepupae		0
fat body, pupae P8		6
carcass, larvae L3 wandering		1
carcass, 1-day adult		0
carcass, 4-day adult		0
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		0
accessory gland, mated 4-day male		0
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		1
central nervous system, larvae L3		1
central nervous system, pupae P8		3
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		0
head, mated 4-day female		0
head, mated 20-day female		0
head, mated 1-day male		0
head, mated 4-day male		0
head, mated 20-day male		0
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		0
digestive system, 20-day adult		0
fat body, larvae L3 wandering		0
fat body, white prepupae		0
fat body, pupae P8		6
carcass, larvae L3 wandering		1
carcass, 1-day adult		0
carcass, 4-day adult		0
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		0
accessory gland, mated 4-day male		0
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		1
central nervous system, larvae L3		1
central nervous system, pupae P8		3
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		0
head, mated 4-day female		0
head, mated 20-day female		0
head, mated 1-day male		0
head, mated 4-day male		0
head, mated 20-day male		0
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		0
digestive system, 20-day adult		0
fat body, larvae L3 wandering		0
fat body, white prepupae		0
fat body, pupae P8		6
carcass, larvae L3 wandering		1
carcass, 1-day adult		0
carcass, 4-day adult		0
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		0
accessory gland, mated 4-day male		0
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Tissue		Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male

modENCODE Development RNA-Seq

modENCODE Temporal Expression Data

(modENCODE_mRNA-Seq_U)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 06-18 hour embryonic stages, during late pupal stages.
[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		1
embryo 08-10hr		3
embryo 10-12hr		9
embryo 12-14hr		10
embryo 14-16hr		13
embryo 16-18hr		5
embryo 18-20hr		2
embryo 20-22hr		1
embryo 22-24hr		1
larva L1		1
larva L2		3
larva L3 12hr old		1
larva L3 puffstage 1-2		0
larva L3 puffstage 3-6		1
larva L3 puffstage 7-9		1
white prepupae new		3
white prepupae 12hr		2
white prepupae 24hr		4
pupae 2d postWPP		10
pupae 3d postWPP		3
pupae 4d postWPP		1
adult male 01day		0
adult male 05day		1
adult male 30day		1
adult female 01day		0
adult female 05day		0
adult female 30day		0
Expression Level Scale		Very low Low Moderate

Linear, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		1
embryo 08-10hr		3
embryo 10-12hr		9
embryo 12-14hr		10
embryo 14-16hr		13
embryo 16-18hr		5
embryo 18-20hr		2
embryo 20-22hr		1
embryo 22-24hr		1
larva L1		1
larva L2		3
larva L3 12hr old		1
larva L3 puffstage 1-2		0
larva L3 puffstage 3-6		1
larva L3 puffstage 7-9		1
white prepupae new		3
white prepupae 12hr		2
white prepupae 24hr		4
pupae 2d postWPP		10
pupae 3d postWPP		3
pupae 4d postWPP		1
adult male 01day		0
adult male 05day		1
adult male 30day		1
adult female 01day		0
adult female 05day		0
adult female 30day		0
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		1
embryo 08-10hr		3
embryo 10-12hr		9
embryo 12-14hr		10
embryo 14-16hr		13
embryo 16-18hr		5
embryo 18-20hr		2
embryo 20-22hr		1
embryo 22-24hr		1
larva L1		1
larva L2		3
larva L3 12hr old		1
larva L3 puffstage 1-2		0
larva L3 puffstage 3-6		1
larva L3 puffstage 7-9		1
white prepupae new		3
white prepupae 12hr		2
white prepupae 24hr		4
pupae 2d postWPP		10
pupae 3d postWPP		3
pupae 4d postWPP		1
adult male 01day		0
adult male 05day		1
adult male 30day		1
adult female 01day		0
adult female 05day		0
adult female 30day		0
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		1
embryo 08-10hr		3
embryo 10-12hr		9
embryo 12-14hr		10
embryo 14-16hr		13
embryo 16-18hr		5
embryo 18-20hr		2
embryo 20-22hr		1
embryo 22-24hr		1
larva L1		1
larva L2		3
larva L3 12hr old		1
larva L3 puffstage 1-2		0
larva L3 puffstage 3-6		1
larva L3 puffstage 7-9		1
white prepupae new		3
white prepupae 12hr		2
white prepupae 24hr		4
pupae 2d postWPP		10
pupae 3d postWPP		3
pupae 4d postWPP		1
adult male 01day		0
adult male 05day		1
adult male 30day		1
adult female 01day		0
adult female 05day		0
adult female 30day		0
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		1
embryo 08-10hr		3
embryo 10-12hr		9
embryo 12-14hr		10
embryo 14-16hr		13
embryo 16-18hr		5
embryo 18-20hr		2
embryo 20-22hr		1
embryo 22-24hr		1
larva L1		1
larva L2		3
larva L3 12hr old		1
larva L3 puffstage 1-2		0
larva L3 puffstage 3-6		1
larva L3 puffstage 7-9		1
white prepupae new		3
white prepupae 12hr		2
white prepupae 24hr		4
pupae 2d postWPP		10
pupae 3d postWPP		3
pupae 4d postWPP		1
adult male 01day		0
adult male 05day		1
adult male 30day		1
adult female 01day		0
adult female 05day		0
adult female 30day		0
Expression Level Scale		Very low Low Moderate

log, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		1
embryo 08-10hr		3
embryo 10-12hr		9
embryo 12-14hr		10
embryo 14-16hr		13
embryo 16-18hr		5
embryo 18-20hr		2
embryo 20-22hr		1
embryo 22-24hr		1
larva L1		1
larva L2		3
larva L3 12hr old		1
larva L3 puffstage 1-2		0
larva L3 puffstage 3-6		1
larva L3 puffstage 7-9		1
white prepupae new		3
white prepupae 12hr		2
white prepupae 24hr		4
pupae 2d postWPP		10
pupae 3d postWPP		3
pupae 4d postWPP		1
adult male 01day		0
adult male 05day		1
adult male 30day		1
adult female 01day		0
adult female 05day		0
adult female 30day		0
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		1
embryo 08-10hr		3
embryo 10-12hr		9
embryo 12-14hr		10
embryo 14-16hr		13
embryo 16-18hr		5
embryo 18-20hr		2
embryo 20-22hr		1
embryo 22-24hr		1
larva L1		1
larva L2		3
larva L3 12hr old		1
larva L3 puffstage 1-2		0
larva L3 puffstage 3-6		1
larva L3 puffstage 7-9		1
white prepupae new		3
white prepupae 12hr		2
white prepupae 24hr		4
pupae 2d postWPP		10
pupae 3d postWPP		3
pupae 4d postWPP		1
adult male 01day		0
adult male 05day		1
adult male 30day		1
adult female 01day		0
adult female 05day		0
adult female 30day		0
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		1
embryo 08-10hr		3
embryo 10-12hr		9
embryo 12-14hr		10
embryo 14-16hr		13
embryo 16-18hr		5
embryo 18-20hr		2
embryo 20-22hr		1
embryo 22-24hr		1
larva L1		1
larva L2		3
larva L3 12hr old		1
larva L3 puffstage 1-2		0
larva L3 puffstage 3-6		1
larva L3 puffstage 7-9		1
white prepupae new		3
white prepupae 12hr		2
white prepupae 24hr		4
pupae 2d postWPP		10
pupae 3d postWPP		3
pupae 4d postWPP		1
adult male 01day		0
adult male 05day		1
adult male 30day		1
adult female 01day		0
adult female 05day		0
adult female 30day		0
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Developmental Stage		Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day

modENCODE Temporal Expression Data (Graveley et al., 2011)

modENCODE Cell Lines RNA-Seq

modENCODE Treatments RNA-Seq

modENCODE Treatment Expression Data

(modENCODE_mRNA-Seq_treatments)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		0
cold shock, 4-day adult		0
heat shock, 4-day adult		0
Cadmium 50 mM 6 hrs, larvae L3		0
Cadmium 50 mM 12 hrs, larvae L3		0
Cadmium 50 mM 48 hrs, 4-day adult		0
Cadmium 100 mM 48 hrs, 4-day adult		1
Copper 0.5 mM 12 hrs, larvae L3		1
Copper 15 mM 48 hrs, 4-day adult		0
Zinc 5 mM 12 hrs, larvae L3		0
Zinc 4.5 mM 48 hrs, 4-day adult		0
Ethanol 2.5% 3 hrs, larvae L3		0
Ethanol 5% 3 hrs, larvae L3		0
Ethanol 10% 3 hrs, larvae L3		0
Caffeine 1.5 mg/ml 4 hrs, larvae L3		0
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		0
Caffeine 25 mg/ml 48 hrs, 4-day adult		0
Paraquat 5 mM 48 hrs, 4-day adult		0
Paraquat 10 mM 48 hrs, 4-day adult		0
Rotenone 2 μg 12 hrs, larvae L3		0
Rotenone 8 μg 12 hrs, larvae L3		0
Expression Level Scale		Very low Low Moderate

Linear, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		0
cold shock, 4-day adult		0
heat shock, 4-day adult		0
Cadmium 50 mM 6 hrs, larvae L3		0
Cadmium 50 mM 12 hrs, larvae L3		0
Cadmium 50 mM 48 hrs, 4-day adult		0
Cadmium 100 mM 48 hrs, 4-day adult		1
Copper 0.5 mM 12 hrs, larvae L3		1
Copper 15 mM 48 hrs, 4-day adult		0
Zinc 5 mM 12 hrs, larvae L3		0
Zinc 4.5 mM 48 hrs, 4-day adult		0
Ethanol 2.5% 3 hrs, larvae L3		0
Ethanol 5% 3 hrs, larvae L3		0
Ethanol 10% 3 hrs, larvae L3		0
Caffeine 1.5 mg/ml 4 hrs, larvae L3		0
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		0
Caffeine 25 mg/ml 48 hrs, 4-day adult		0
Paraquat 5 mM 48 hrs, 4-day adult		0
Paraquat 10 mM 48 hrs, 4-day adult		0
Rotenone 2 μg 12 hrs, larvae L3		0
Rotenone 8 μg 12 hrs, larvae L3		0
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		0
cold shock, 4-day adult		0
heat shock, 4-day adult		0
Cadmium 50 mM 6 hrs, larvae L3		0
Cadmium 50 mM 12 hrs, larvae L3		0
Cadmium 50 mM 48 hrs, 4-day adult		0
Cadmium 100 mM 48 hrs, 4-day adult		1
Copper 0.5 mM 12 hrs, larvae L3		1
Copper 15 mM 48 hrs, 4-day adult		0
Zinc 5 mM 12 hrs, larvae L3		0
Zinc 4.5 mM 48 hrs, 4-day adult		0
Ethanol 2.5% 3 hrs, larvae L3		0
Ethanol 5% 3 hrs, larvae L3		0
Ethanol 10% 3 hrs, larvae L3		0
Caffeine 1.5 mg/ml 4 hrs, larvae L3		0
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		0
Caffeine 25 mg/ml 48 hrs, 4-day adult		0
Paraquat 5 mM 48 hrs, 4-day adult		0
Paraquat 10 mM 48 hrs, 4-day adult		0
Rotenone 2 μg 12 hrs, larvae L3		0
Rotenone 8 μg 12 hrs, larvae L3		0
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		0
cold shock, 4-day adult		0
heat shock, 4-day adult		0
Cadmium 50 mM 6 hrs, larvae L3		0
Cadmium 50 mM 12 hrs, larvae L3		0
Cadmium 50 mM 48 hrs, 4-day adult		0
Cadmium 100 mM 48 hrs, 4-day adult		1
Copper 0.5 mM 12 hrs, larvae L3		1
Copper 15 mM 48 hrs, 4-day adult		0
Zinc 5 mM 12 hrs, larvae L3		0
Zinc 4.5 mM 48 hrs, 4-day adult		0
Ethanol 2.5% 3 hrs, larvae L3		0
Ethanol 5% 3 hrs, larvae L3		0
Ethanol 10% 3 hrs, larvae L3		0
Caffeine 1.5 mg/ml 4 hrs, larvae L3		0
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		0
Caffeine 25 mg/ml 48 hrs, 4-day adult		0
Paraquat 5 mM 48 hrs, 4-day adult		0
Paraquat 10 mM 48 hrs, 4-day adult		0
Rotenone 2 μg 12 hrs, larvae L3		0
Rotenone 8 μg 12 hrs, larvae L3		0
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		0
cold shock, 4-day adult		0
heat shock, 4-day adult		0
Cadmium 50 mM 6 hrs, larvae L3		0
Cadmium 50 mM 12 hrs, larvae L3		0
Cadmium 50 mM 48 hrs, 4-day adult		0
Cadmium 100 mM 48 hrs, 4-day adult		1
Copper 0.5 mM 12 hrs, larvae L3		1
Copper 15 mM 48 hrs, 4-day adult		0
Zinc 5 mM 12 hrs, larvae L3		0
Zinc 4.5 mM 48 hrs, 4-day adult		0
Ethanol 2.5% 3 hrs, larvae L3		0
Ethanol 5% 3 hrs, larvae L3		0
Ethanol 10% 3 hrs, larvae L3		0
Caffeine 1.5 mg/ml 4 hrs, larvae L3		0
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		0
Caffeine 25 mg/ml 48 hrs, 4-day adult		0
Paraquat 5 mM 48 hrs, 4-day adult		0
Paraquat 10 mM 48 hrs, 4-day adult		0
Rotenone 2 μg 12 hrs, larvae L3		0
Rotenone 8 μg 12 hrs, larvae L3		0
Expression Level Scale		Very low Low Moderate

log, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		0
cold shock, 4-day adult		0
heat shock, 4-day adult		0
Cadmium 50 mM 6 hrs, larvae L3		0
Cadmium 50 mM 12 hrs, larvae L3		0
Cadmium 50 mM 48 hrs, 4-day adult		0
Cadmium 100 mM 48 hrs, 4-day adult		1
Copper 0.5 mM 12 hrs, larvae L3		1
Copper 15 mM 48 hrs, 4-day adult		0
Zinc 5 mM 12 hrs, larvae L3		0
Zinc 4.5 mM 48 hrs, 4-day adult		0
Ethanol 2.5% 3 hrs, larvae L3		0
Ethanol 5% 3 hrs, larvae L3		0
Ethanol 10% 3 hrs, larvae L3		0
Caffeine 1.5 mg/ml 4 hrs, larvae L3		0
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		0
Caffeine 25 mg/ml 48 hrs, 4-day adult		0
Paraquat 5 mM 48 hrs, 4-day adult		0
Paraquat 10 mM 48 hrs, 4-day adult		0
Rotenone 2 μg 12 hrs, larvae L3		0
Rotenone 8 μg 12 hrs, larvae L3		0
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		0
cold shock, 4-day adult		0
heat shock, 4-day adult		0
Cadmium 50 mM 6 hrs, larvae L3		0
Cadmium 50 mM 12 hrs, larvae L3		0
Cadmium 50 mM 48 hrs, 4-day adult		0
Cadmium 100 mM 48 hrs, 4-day adult		1
Copper 0.5 mM 12 hrs, larvae L3		1
Copper 15 mM 48 hrs, 4-day adult		0
Zinc 5 mM 12 hrs, larvae L3		0
Zinc 4.5 mM 48 hrs, 4-day adult		0
Ethanol 2.5% 3 hrs, larvae L3		0
Ethanol 5% 3 hrs, larvae L3		0
Ethanol 10% 3 hrs, larvae L3		0
Caffeine 1.5 mg/ml 4 hrs, larvae L3		0
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		0
Caffeine 25 mg/ml 48 hrs, 4-day adult		0
Paraquat 5 mM 48 hrs, 4-day adult		0
Paraquat 10 mM 48 hrs, 4-day adult		0
Rotenone 2 μg 12 hrs, larvae L3		0
Rotenone 8 μg 12 hrs, larvae L3		0
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		0
cold shock, 4-day adult		0
heat shock, 4-day adult		0
Cadmium 50 mM 6 hrs, larvae L3		0
Cadmium 50 mM 12 hrs, larvae L3		0
Cadmium 50 mM 48 hrs, 4-day adult		0
Cadmium 100 mM 48 hrs, 4-day adult		1
Copper 0.5 mM 12 hrs, larvae L3		1
Copper 15 mM 48 hrs, 4-day adult		0
Zinc 5 mM 12 hrs, larvae L3		0
Zinc 4.5 mM 48 hrs, 4-day adult		0
Ethanol 2.5% 3 hrs, larvae L3		0
Ethanol 5% 3 hrs, larvae L3		0
Ethanol 10% 3 hrs, larvae L3		0
Caffeine 1.5 mg/ml 4 hrs, larvae L3		0
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		0
Caffeine 25 mg/ml 48 hrs, 4-day adult		0
Paraquat 5 mM 48 hrs, 4-day adult		0
Paraquat 10 mM 48 hrs, 4-day adult		0
Rotenone 2 μg 12 hrs, larvae L3		0
Rotenone 8 μg 12 hrs, larvae L3		0
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Treatment		Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3

Expression Clusters

A cluster of genes with similar mRNA expression dynamics across development.

(The modENCODE Consortium, 2010)

mE2_34_mRNA_expression_cluster_07

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0039294

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG13664-RA;CG10421-RA

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

partially lethal - majority die | pupal stage, with Scer\GAL4^pnr-MD237

Cad96Cb^GD8088

viable, with Scer\GAL4^pnr-MD237

Phenotype manifest in

Allele

Classical Alleles ( 1 )

For All Classical Alleles Show

Allele of Cad96Cb	Class	Mutagen	Stocks	Known lesion
Cad96Cb^e01506			1	--

Alleles Carried on Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Allele of Cad96Cb	Mutagen	Stocks	Known lesion
Cad96Cb^GD14465	in vitro construct - RNAi in vitro construct - regulatory fusion	2	Yes
Cad96Cb^GD154	in vitro construct - RNAi in vitro construct - regulatory fusion	2	Yes
Cad96Cb^GD2650	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
Cad96Cb^GD8088	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
Cad96Cb^JF01881	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
Cad96Cb^KK112803	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
Cad96Cb^a.cLa	in vitro construct - RNAi	0	Yes
Cad96Cb^cLa	in vitro construct - RNAi	0	Yes

Aneuploid Aberrations

Disrupted in

Df(3R)FDD-0089346

(DrosDel Project, 2008.11.14)

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

Insertions

Type of insertions

Name

Expression data

miscellaneous insertions

PBac{RB}Cad96Cb^e01506

Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )

Terms Based on Experimental Evidence ( 1 term )

Molecular Function ( 0 terms)

Biological Process

CV term

Evidence

References

open tracheal system development

inferred from genetic interaction with shg

(Lovegrove et al., 2006)

Cellular Component ( 0 terms)

Terms Based on Predictions or Assertions ( 5 terms )

Molecular Function

CV term

Evidence

References

calcium ion binding

inferred from electronic annotation with InterPro:IPR002126, InterPro:IPR015919

(FlyBase Curators et al., 2004-)

Biological Process

CV term

Evidence

References

calcium-dependent cell-cell adhesion

inferred from sequence or structural similarity

(Hynes and Zhao, 2000)

homophilic cell adhesion

inferred from electronic annotation with InterPro:IPR002126

(FlyBase Curators et al., 2004-)

Cellular Component

CV term

Evidence

References

integral to plasma membrane

inferred from sequence or structural similarity

(Hynes and Zhao, 2000)

plasma membrane

inferred from electronic annotation with InterPro:IPR020894

(FlyBase Curators et al., 2004-)

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Interactions & Pathways

Summary of Physical Interactions

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

Cad96Cb allele

Gene

References

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0039294

Orthologs

OrthoDB Orthologs (34) - based on analysis using Dmel annotation version 5.41

OrthoDB Ortholog Groups

OrthoDB orthology group searches

(Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288)

Drosophila inclusive ortholog search

EOG6GB7RN

Dipteran inclusive ortholog search

EOG65TCWG

Insect inclusive ortholog search

EOG6DND13

Arthropod inclusive ortholog search

EOG62RBPX

Metazoa inclusive ortholog search

EOG6ZH263

Orthologs in Drosophila Species (EOG6GB7RN)

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA10308

Drosophila persimilis

Dper\GL12620

Drosophila willistoni

Dwil\GK13841

Drosophila virilis

Dvir\GJ23230

Drosophila mojavensis

Dmoj\GI23670

Drosophila grimshawi

Dgri\GH14626

Orthologs in non-Drosophila Dipterans (EOG65TCWG)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL007299

Anopheles gambiae

Malaria mosquito

Agam\AGAP003607

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ003739

Orthologs in non-Dipteran Insects (EOG6DND13)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Apis mellifera

Western honey bee

Amel\GB53331

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG022741

Acromyrmex echinatior

Panamanian leafcutter ant

Aech\AECH10795

Atta cephalotes

Leafcutter ant

Acep\ACEP13512

Atta cephalotes

Leafcutter ant

Acep\ACEP13501

Camponotus floridanus

Florida carpenter ant

Cflo\CFLO21949

Harpegnathos saltator

Jerdons jumping ant

Hsal\HSAL12868

Linepithema humile

Argentine ant

Lhum\LH22037

Pogonomyrmex barbatus

Red harvester ant

Pbar\PB12281

Pogonomyrmex barbatus

Red harvester ant

Pbar\PB10484

Solenopsis invicta

Red fire ant

Sinv\SINV13258

Solenopsis invicta

Red fire ant

Sinv\SINV13261

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI006324

Bombyx mori

Silkmoth

Bmor\BGIBMGA002162

Pediculus humanus

Human body louse

Phum\PHUM489430

Tribolium castaneum

Red flour beetle

Tcas\TC010411

Orthologs in non-Insect Arthropods (EOG62RBPX)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Daphnia pulex

Water flea

Dpux\pol

Ixodes scapularis

Deer tick

Isca\ISCW016805

Orthologs in non-Arthropod Metazoa (EOG6ZH263)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Caenorhabditis elegans

Nematode

Cele\cdh-9

Human Orthologs (0)

Gene

OMIM

HGNC

AAA Orthologs (11) based on analysis using Dmel annotation version 4.3

Organism

Gene

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA10308

Drosophila persimilis

Dper\GL12620

Drosophila willistoni

Dwil\GK13841

Drosophila virilis

Dvir\GJ23230

Drosophila mojavensis

Dmoj\GI23670

Drosophila grimshawi

Dgri\GH14626

Stocks & Reagents

Stocks Listed in FlyBase ( 9 )

Bloomington

25860

y¹ v¹; P{TRiP.JF01881}attP2

Harvard

PBac{RB}Cad96Cb^e01506

v103296

v4339

v4340

v19727

w¹¹¹⁸; P{GD2650}v19727

v39800

w¹¹¹⁸; P{GD8088}v39800

v36336

w¹¹¹⁸; P{GD14465}v36336

v36337

w¹¹¹⁸; P{GD14465}v36337/CyO

Genomic Clones ( 2 )

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones ( 9 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones