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Gene Dmel\to

General Information
Symbol	Dmel\to	Species	D. melanogaster
Name	takeout	Annotation symbol	CG11853
Feature type	protein_coding_gene	FlyBase ID	FBgn0039298
Gene Model Status	Current	Stock availability	6 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	96C7-96C7	Sequence location	3R:21,065,902..21,067,390 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene takeout is referred to in FlyBase by the symbol Dmel\to (CG11853, FBgn0039298). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: behavioral response to starvation; circadian rhythm; adult feeding behavior; male courtship behavior. 10 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Haemolymph juvenile hormone binding. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of no expression detected. Peak expression observed in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult crop, adult midgut, adult hindgut, larval trachea. Expression at moderate levels in the following post-embryonic organs or tissues: larval hindgut, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1635636_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of to. Gene sequence location is 3R:21065902..21067390.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 96C7-96C7   Limits computationally determined from genome sequence between P{lacW}OstStt3j2D9 and P{PZ}Aats-gln05461
Experimentally Determined Cytological Location
Cytogenetic map Notes References 96B19-96C6     (So, 2000.4.28) 96B19-96C6     (Sarov-Blat et al., 2000)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\to for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.49 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) to-RA FBtr0084810  NM_079773   1038   249 to-RB FBtr0339258     1253   249
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein to-PA   FBpp0084185   27.3   249   7.93     NP_524497   AAF56425 to-PB   FBpp0308365   27.3   249   7.93
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Haemolymph juvenile hormone binding (IPR010562)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF56425   AF261748 AAF79960   AI064306   AI107005   AI107767   AI109754   AI114099   AI238846   AI402015   AI403044   AI403166   AI404340   AI405970   AI513380   AY122096 AAM52608   AY232143   CO320972   EC067297   EL869928   EL869929   EL869930   EL869931   EL880901
UniProtKB/Swiss-Prot	Q9VBV3
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
extracellular region inferred from direct assay (assigned by UniProtKB) (Sarov-Blat et al., 2000) extracellular space inferred from direct assay (Lazareva et al., 2007)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult crop, adult midgut, adult hindgut, larval trachea. Expression at moderate levels in the following post-embryonic organs or tissues: larval hindgut, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    1.375 Larval Midgut    5 Larval Hindgut    254.4 Larval Malpighian Tubules    5.5 Larval Fat Body    4.3 Larval Salivary Gland    6.2 Larval Trachea    1044.925 Larval Carcass    11.3 Adult Head    887.9 Adult Eye    581.725 Adult Brain    38.2 Adult Thoracic-Abdominal Ganglion    39.2 Adult Crop    972.1 Adult Midgut    810 Adult Hindgut    1297.1 Adult Malpighian Tubules    18.4 Adult Fat Body    9.8 Adult Salivary Gland    16.4 Adult Heart    29.175 Adult VirginFemale Spermatheca    5.2 Adult InseminatedFemale Spermatheca    4.7 Adult Ovary    1.1 Adult Testis    5.3 Adult Male Accessory Gland    13.9 Adult Carcass    200.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    1.375 Larval Midgut    5 Larval Hindgut    254.4 Larval Malpighian Tubules    5.5 Larval Fat Body    4.3 Larval Salivary Gland    6.2 Larval Trachea  (1044.925) Larval Carcass    11.3 Adult Head  (887.9) Adult Eye  (581.725) Adult Brain    38.2 Adult Thoracic-Abdominal Ganglion    39.2 Adult Crop  (972.1) Adult Midgut  (810) Adult Hindgut  (1297.1) Adult Malpighian Tubules    18.4 Adult Fat Body    9.8 Adult Salivary Gland    16.4 Adult Heart    29.175 Adult VirginFemale Spermatheca    5.2 Adult InseminatedFemale Spermatheca    4.7 Adult Ovary    1.1 Adult Testis    5.3 Adult Male Accessory Gland    13.9 Adult Carcass    200.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    1.375 Larval Midgut    5 Larval Hindgut    254.4 Larval Malpighian Tubules    5.5 Larval Fat Body    4.3 Larval Salivary Gland    6.2 Larval Trachea  1044.925 Larval Carcass    11.3 Adult Head    887.9 Adult Eye    581.725 Adult Brain    38.2 Adult Thoracic-Abdominal Ganglion    39.2 Adult Crop    972.1 Adult Midgut    810 Adult Hindgut  (1297.1) Adult Malpighian Tubules    18.4 Adult Fat Body    9.8 Adult Salivary Gland    16.4 Adult Heart    29.175 Adult VirginFemale Spermatheca    5.2 Adult InseminatedFemale Spermatheca    4.7 Adult Ovary    1.1 Adult Testis    5.3 Adult Male Accessory Gland    13.9 Adult Carcass    200.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1.375 Larval Midgut    5 Larval Hindgut    254.4 Larval Malpighian Tubules    5.5 Larval Fat Body    4.3 Larval Salivary Gland    6.2 Larval Trachea    1044.925 Larval Carcass    11.3 Adult Head    887.9 Adult Eye    581.725 Adult Brain    38.2 Adult Thoracic-Abdominal Ganglion    39.2 Adult Crop    972.1 Adult Midgut    810 Adult Hindgut    1297.1 Adult Malpighian Tubules    18.4 Adult Fat Body    9.8 Adult Salivary Gland    16.4 Adult Heart    29.175 Adult VirginFemale Spermatheca    5.2 Adult InseminatedFemale Spermatheca    4.7 Adult Ovary    1.1 Adult Testis    5.3 Adult Male Accessory Gland    13.9 Adult Carcass    200.2 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    1.375 Larval Midgut    5 Larval Hindgut    254.4 Larval Malpighian Tubules    5.5 Larval Fat Body    4.3 Larval Salivary Gland    6.2 Larval Trachea    1044.925 Larval Carcass    11.3 Adult Head    887.9 Adult Eye    581.725 Adult Brain    38.2 Adult Thoracic-Abdominal Ganglion    39.2 Adult Crop    972.1 Adult Midgut    810 Adult Hindgut    1297.1 Adult Malpighian Tubules    18.4 Adult Fat Body    9.8 Adult Salivary Gland    16.4 Adult Heart    29.175 Adult VirginFemale Spermatheca    5.2 Adult InseminatedFemale Spermatheca    4.7 Adult Ovary    1.1 Adult Testis    5.3 Adult Male Accessory Gland    13.9 Adult Carcass    200.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    1.375 Larval Midgut    5 Larval Hindgut    254.4 Larval Malpighian Tubules    5.5 Larval Fat Body    4.3 Larval Salivary Gland    6.2 Larval Trachea  (1044.925) Larval Carcass    11.3 Adult Head  (887.9) Adult Eye  581.725 Adult Brain    38.2 Adult Thoracic-Abdominal Ganglion    39.2 Adult Crop  (972.1) Adult Midgut  810 Adult Hindgut  (1297.1) Adult Malpighian Tubules    18.4 Adult Fat Body    9.8 Adult Salivary Gland    16.4 Adult Heart    29.175 Adult VirginFemale Spermatheca    5.2 Adult InseminatedFemale Spermatheca    4.7 Adult Ovary    1.1 Adult Testis    5.3 Adult Male Accessory Gland    13.9 Adult Carcass    200.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    1.375 Larval Midgut    5 Larval Hindgut    254.4 Larval Malpighian Tubules    5.5 Larval Fat Body    4.3 Larval Salivary Gland    6.2 Larval Trachea  1044.925 Larval Carcass    11.3 Adult Head    887.9 Adult Eye    581.725 Adult Brain    38.2 Adult Thoracic-Abdominal Ganglion    39.2 Adult Crop    972.1 Adult Midgut    810 Adult Hindgut  1297.1 Adult Malpighian Tubules    18.4 Adult Fat Body    9.8 Adult Salivary Gland    16.4 Adult Heart    29.175 Adult VirginFemale Spermatheca    5.2 Adult InseminatedFemale Spermatheca    4.7 Adult Ovary    1.1 Adult Testis    5.3 Adult Male Accessory Gland    13.9 Adult Carcass    200.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1.375 Larval Midgut    5 Larval Hindgut    254.4 Larval Malpighian Tubules    5.5 Larval Fat Body    4.3 Larval Salivary Gland    6.2 Larval Trachea    1044.925 Larval Carcass    11.3 Adult Head    887.9 Adult Eye    581.725 Adult Brain    38.2 Adult Thoracic-Abdominal Ganglion    39.2 Adult Crop    972.1 Adult Midgut    810 Adult Hindgut    1297.1 Adult Malpighian Tubules    18.4 Adult Fat Body    9.8 Adult Salivary Gland    16.4 Adult Heart    29.175 Adult VirginFemale Spermatheca    5.2 Adult InseminatedFemale Spermatheca    4.7 Adult Ovary    1.1 Adult Testis    5.3 Adult Male Accessory Gland    13.9 Adult Carcass    200.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    887.9   NA  Eye    581.725   NA  Brain    38.2   1.375  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    no informative data   NA  Crop    972.1   5  Midgut    810   254.4  Hindgut    1297.1   5.5  Malpighian Tubules    no informative data   4.3  Fat Body    9.8   6.2  Salivary Gland    no informative data   NA  Heart    29.175   1044.925  Trachea    NA   NA  VirginFemale Spermatheca    5.2   NA  InseminatedFemale Spermatheca    4.7   NA  Ovary    1.1   NA  Testis    5.3   NA  Male Accessory Gland    no informative data   no informative data  Carcass    200.2 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    9 head, virgin 4-day female    9 head, virgin 20-day female    16 head, mated 1-day female    8 head, mated 4-day female    17 head, mated 20-day female    20 head, mated 1-day male    5 head, mated 4-day male    13 head, mated 20-day male    38 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    36 digestive system, 4-day adult    24 digestive system, 20-day adult    29 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    4 carcass, 4-day adult    7 carcass, 20-day adult    8 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    9 head, virgin 4-day female    9 head, virgin 20-day female    16 head, mated 1-day female    8 head, mated 4-day female    17 head, mated 20-day female    20 head, mated 1-day male    5 head, mated 4-day male    13 head, mated 20-day male  (38) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult  (36) digestive system, 4-day adult    24 digestive system, 20-day adult  (29) fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    4 carcass, 4-day adult    7 carcass, 20-day adult    8 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    9 head, virgin 4-day female    9 head, virgin 20-day female    16 head, mated 1-day female    8 head, mated 4-day female    17 head, mated 20-day female    20 head, mated 1-day male    5 head, mated 4-day male    13 head, mated 20-day male    38 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    36 digestive system, 4-day adult    24 digestive system, 20-day adult    29 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    4 carcass, 4-day adult    7 carcass, 20-day adult    8 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    9 head, virgin 4-day female    9 head, virgin 20-day female    16 head, mated 1-day female    8 head, mated 4-day female    17 head, mated 20-day female    20 head, mated 1-day male    5 head, mated 4-day male    13 head, mated 20-day male    38 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    36 digestive system, 4-day adult    24 digestive system, 20-day adult    29 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    4 carcass, 4-day adult    7 carcass, 20-day adult    8 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    9 head, virgin 4-day female    9 head, virgin 20-day female    16 head, mated 1-day female    8 head, mated 4-day female    17 head, mated 20-day female    20 head, mated 1-day male    5 head, mated 4-day male    13 head, mated 20-day male    38 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    36 digestive system, 4-day adult    24 digestive system, 20-day adult    29 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    4 carcass, 4-day adult    7 carcass, 20-day adult    8 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    9 head, virgin 4-day female    9 head, virgin 20-day female    16 head, mated 1-day female    8 head, mated 4-day female    17 head, mated 20-day female    20 head, mated 1-day male    5 head, mated 4-day male    13 head, mated 20-day male  (38) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult  (36) digestive system, 4-day adult    24 digestive system, 20-day adult  29 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    4 carcass, 4-day adult    7 carcass, 20-day adult    8 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    9 head, virgin 4-day female    9 head, virgin 20-day female    16 head, mated 1-day female    8 head, mated 4-day female    17 head, mated 20-day female    20 head, mated 1-day male    5 head, mated 4-day male    13 head, mated 20-day male    38 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    36 digestive system, 4-day adult    24 digestive system, 20-day adult    29 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    4 carcass, 4-day adult    7 carcass, 20-day adult    8 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    9 head, virgin 4-day female    9 head, virgin 20-day female    16 head, mated 1-day female    8 head, mated 4-day female    17 head, mated 20-day female    20 head, mated 1-day male    5 head, mated 4-day male    13 head, mated 20-day male    38 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    36 digestive system, 4-day adult    24 digestive system, 20-day adult    29 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    4 carcass, 4-day adult    7 carcass, 20-day adult    8 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of no expression detected. Peak expression observed in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    1 larva L1    1 larva L2    0 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    2 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    1 adult male 01day    34 adult male 05day    114 adult male 30day    213 adult female 01day    12 adult female 05day    10 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    1 larva L1    1 larva L2    0 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    2 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    1 adult male 01day  (34) adult male 05day  (114) adult male 30day  (213) adult female 01day    12 adult female 05day    10 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    1 larva L1    1 larva L2    0 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    2 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    1 adult male 01day    34 adult male 05day  (114) adult male 30day  (213) adult female 01day    12 adult female 05day    10 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    1 larva L1    1 larva L2    0 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    2 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    1 adult male 01day    34 adult male 05day    114 adult male 30day    213 adult female 01day    12 adult female 05day    10 adult female 30day    18 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    1 larva L1    1 larva L2    0 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    2 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    1 adult male 01day    34 adult male 05day    114 adult male 30day    213 adult female 01day    12 adult female 05day    10 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    1 larva L1    1 larva L2    0 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    2 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    1 adult male 01day  (34) adult male 05day  (114) adult male 30day  (213) adult female 01day    12 adult female 05day    10 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    1 larva L1    1 larva L2    0 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    2 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    1 adult male 01day    34 adult male 05day  114 adult male 30day  (213) adult female 01day    12 adult female 05day    10 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    1 larva L1    1 larva L2    0 larva L3 12hr old    1 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    2 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    1 adult male 01day    34 adult male 05day    114 adult male 30day    213 adult female 01day    12 adult female 05day    10 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (Graveley et al., 2011) mE1_20_mRNA_expression_cluster_20
External Data & Images
Linkouts	BDGP expression data • GH05615 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039298 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11853-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele partially lethal - majority live to1 viable toc00632 Sterility Allele fertile toc00632 Other Phenotypes Allele circadian rhythm defective to1 feeding behavior defective | adult stage to1 Phenotype manifest in Allele
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of to Class Mutagen Stocks Known lesion toc00632 piggyBac transposase 2 -- to+t6.4 0 Yes to1 0 Yes
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of to Class Mutagen Stocks Known lesion toGD1195 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes toKK103518 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes toScer\UAS.cZa in vitro construct - regulatory fusion 1 Yes toGD15283 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes toNIG.11583R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes toScer\UAS.cLa in vitro construct - regulatory fusion 0 Yes toScer\UAS.cSBa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)FDD-0089346 (DrosDel Project, 2008.11.14) Df(3R)FDD-0247625 (DrosDel Project, 2008.11.14) Df(3R)FDD-0247627 (DrosDel Project, 2008.11.14)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1195} NA P{GD15283} NA P{KK103518} NA P{NIG.11583R} NA P{UAS-to.L} NA P{UAS-to.Z} NA P{UAS-to} NA reporter construct P{to21e-lacZ} No P{to21-lacZ} No P{to80x3-lacZ} No characterization construct P{to80ex3-luc} NA P{to80x3-luc} NA P{to-GAL4.D} NA P{to-luc.S} NA P{to-luc.ΔE} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{PB}toc00632 NA
Gene Ontology: Function, Process & Cellular Component ( 10 unique terms )
	There is no information supporting a molecular function term for this gene. (Based on a review of available data before: 2006)
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
adult feeding behavior inferred from mutant phenotype (Wong et al., 2009) behavioral response to starvation inferred from mutant phenotype (assigned by UniProtKB) (Sarov-Blat et al., 2000) circadian rhythm inferred from expression pattern (So et al., 2000) male courtship behavior inferred from genetic interaction with fru AND inferred from mutant phenotype (Dauwalder et al., 2002)
Cellular Component
CV term Evidence References
extracellular region inferred from direct assay (assigned by UniProtKB) (Sarov-Blat et al., 2000) extracellular space inferred from direct assay (Lazareva et al., 2007)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
circadian rhythm non-traceable author statement (Sokolowski, 2001) traceable author statement (Panda et al., 2002, Hendricks, 2003) feeding behavior non-traceable author statement (Sokolowski, 2001) traceable author statement (So et al., 2000, Hendricks, 2003) mating behavior traceable author statement (Anholt, 2004) response to starvation traceable author statement (Stanewsky, 2003) rhythmic behavior traceable author statement (Stanewsky, 2003)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions to allele Gene References to1 fru (Dauwalder et al., 2002)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67955 DroID - A comprehensive database of gene and protein interactions. • FBgn0039298 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43036
Orthologs
OrthoDB Orthologs (27) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6F4SXJ Dipteran inclusive ortholog search EOG6001TG Insect inclusive ortholog search EOG64XHD3 Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6F4SXJ)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\to     Drosophila simulans   Dsim\GD21190 Y   Drosophila sechellia   Dsec\GM17822 Y   Drosophila erecta   Dere\GG11379 Y   Drosophila yakuba   Dyak\to Y   Drosophila ananassae   Dana\GF17553 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA11237 Y   Drosophila persimilis   Dper\GL11988 Y   Drosophila willistoni   Dwil\GK13451 Y   Drosophila virilis   Dvir\GJ24018 Y   Drosophila virilis   Dvir\GJ24019     Drosophila mojavensis   Dmoj\GI23925 Y   Drosophila grimshawi   Dgri\GH17381 Y   Drosophila grimshawi   Dgri\GH14735
Orthologs in non-Drosophila Dipterans (EOG6001TG)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL011966   Anopheles gambiae Malaria mosquito  Agam\AGAP004262   Anopheles gambiae Malaria mosquito  Agam\AGAP012703   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ015482
Orthologs in non-Dipteran Insects (EOG64XHD3)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Acyrthosiphon pisum Pea aphid  Apim\ACYPI009456 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI001245 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI004280 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI007558 Y Bombyx mori Silkmoth  Bmor\BGIBMGA001325 Y Pediculus humanus Human body louse  Phum\PHUM210810 Y Pediculus humanus Human body louse  Phum\PHUM535140 Y Tribolium castaneum Red flour beetle  Tcas\GLEAN_15844 Y Tribolium castaneum Red flour beetle  Tcas\GLEAN_15845 Y
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD21190 Drosophila sechellia Dsec\GM17822 Drosophila erecta Dere\GG11379 Drosophila yakuba Dyak\to Drosophila ananassae Dana\GF17553 Drosophila pseudoobscura pseudoobscura Dpse\GA11237 Drosophila persimilis Dper\GL11988 Drosophila willistoni Dwil\GK13451 Drosophila virilis Dvir\GJ24018 Drosophila mojavensis Dmoj\GI23925 Drosophila grimshawi Dgri\GH17381
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	27646 y1 w*; P{UAS-to.Z}2A 10202 w1118; PBac{PB}toc00632
Harvard	- PBac{PB}toc00632
VDRC	v100079 P{KK103518}VIE-260B v51462 w1118; P{GD1195}v51462 v51463 w1118; P{GD1195}v51463
Genomic Clones ( 3 )
	BACR06L08 BACR10P10 BACR17E12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 16 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH05615
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH04677 GH06283 GH09067 GH10779 GH14970 GH22404 GH22550 GH24001 GH26136 GH26565
Other clones	184537 EK289451 IP02063 IP02064 IP10729
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0039298 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43036
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: to CG11853 (FlyBase, 1996-)
Source for database merge of
Additional comments	Source for identity of to CG11853 was sequence comparison (date:000721). (FlyBase, 1996-)
Other Comments
	to functions in courtship. to does not play a developmental role but has a physiological role in adults. (Lazareva et al., 2007) to is present in the haemolymph of adult males but not females and acts as a secreted protein. (Lazareva et al., 2007) to is required for normal levels of male courtship behaviour and might have a role in integrating information about the organism's sex, nutritional status, and circadian cycle to affect male behaviour. (Dauwalder et al., 2002) Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days. Shows significant change of expression pattern in circadian mutant background; increased expression in per01, tim01 and decreased expression in ClkJrk background. (Claridge-Chang et al., 2001) Identified as a gene with significant level of mRNA cycling as assessed by expression analysis using high density oligonucleotide arrays with probe generated from adult heads harvested over six time points over the course of a day. (McDonald and Rosbash, 2001) to may participate in a novel circadian output pathway that conveys temporal and food status information to feeding-relevant metabolisms and activity. (Sarov-Blat et al., 2000) to is a clock regulated output gene. (So et al., 2000)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079773 RefSeq (Proteins) • NP_524497 DDBJ / EMBL / GenBank • AAF56425 AAF79960 AAM52608 AF261748 AI107767 AI402015 AY122096 Entrez Gene - A searchable database of RefSeq genes. • 43036 UniProtKB/Swiss-Prot • Q9VBV3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Haemolymph juvenile hormone binding (IPR010562) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH05615
Linkouts
	BioGRID - A database of protein and genetic interactions • 67955 DroID - A comprehensive database of gene and protein interactions. • FBgn0039298 DRSC - Results from RNAi screens. • FBgn0039298 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039298 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11853-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0039298 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43036 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /hjmuller/takeout1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43036 modMine - Data generated by the modENCODE project. • FBgn0039298
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	CG11853 (Apidianakis et al., 2005, McDonald and Rosbash, 2001, Keleman et al., 2009.8.5) CT33074 (Ceriani et al., 2002) to (Benito et al., 2010, Lazareva et al., 2007, Domazet-Loso and Tautz, 2003, Goldman and Arbeitman, 2007, Haerty et al., 2007, Sheldon et al., 2011, Allen and Spradling, 2008, Zheng and Sehgal, 2009.6.26, Meunier et al., 2007, Ruedi and Hughes, 2009, Xu et al., 2008, Terashima and Bownes, 2005, Kim et al., 2010, Dalton et al., 2010, Japanese National Institute of Genetics, 2012.5.21)
Name Synonym	Takeout (Pedersen et al., 2008, Lazareva et al., 2007) takeout (So, 2000.4.28, Kadener et al., 2006, Benito et al., 2010, Hoxha et al., 2008, Goldman and Arbeitman, 2007, Antosh et al., 2011, Bauer et al., 2010, Sheldon et al., 2011, Farhadian et al., 2012, Allen and Spradling, 2008, Wong et al., 2009, Meunier et al., 2007, Ruedi and Hughes, 2009, Xu et al., 2008, Kim et al., 2010, Terashima and Bownes, 2005, Kim et al., 2010) take-out (Virágh et al., 2007)
Secondary FlyBase IDs
References ( 68 )
Generate a list of	All references relating to this gene ( 68 )
List References by type	Research paper  ( 36 ) Supplementary material  ( 2 ) Review  ( 9 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 7 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Stock list  ( 1 ) Letter  ( 1 )
Recent research papers ( 6 )
	Chamseddin et al., 2012, Mech. Ageing Dev. 133(11-12): 637--646 takeout-dependent longevity is associated with altered Juvenile Hormone signaling. [FBrf0220268] Farhadian et al., 2012, Physiol. Behav. 105(2): 544--553 Post-fasting olfactory, transcriptional, and feeding responses in Drosophila. [FBrf0216753] Vanaphan et al., 2012, Gene 491(2): 142--148 Diversification of takeout, a male-biased gene family in Drosophila. [FBrf0216815] Antosh et al., 2011, Cell Cycle 10(6): 904--911 Comparative transcriptional pathway bioinformatic analysis of dietary restriction, Sir2, p53 and resveratrol life span extension in Drosophila. [FBrf0213419] Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Sheldon et al., 2011, PLoS ONE 6(8): e23343 SLOB, a SLOWPOKE Channel Binding Protein, Regulates Insulin Pathway Signaling and Metabolism in Drosophila. [FBrf0214706] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...