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Gene Dmel\to

General Information
Symbol	Dmel\to	Species	D. melanogaster
Name	takeout	Annotation symbol	CG11853
Feature type	protein_coding_gene	FlyBase ID	FBgn0039298
Gene Model Status	Current	Stock availability	6 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	96C7-96C7	Sequence location	3R:21,065,902..21,067,175 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene takeout is referred to in FlyBase by the symbol Dmel\to (CG11853, FBgn0039298). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: behavioral response to starvation; circadian rhythm; adult feeding behavior; male courtship behavior. 9 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Hormone binding; Odorant binding protein. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of no expression detected. Peak expression observed in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult crop, adult midgut, adult hindgut, larval trachea. Expression at moderate levels in the following post-embryonic organs or tissues: larval hindgut, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1635636_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of to. Gene sequence location is 3R:21065902..21067175.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References Kim et al., 2010, Exp. Gerontol. 45(12): 984--987 Dalton et al., 2010, BMC Genomics 11: 541 Vanaphan et al., 2012, Gene 491(2): 142--148 Sequence features BKN23710 HFA17086
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 96C7-96C7   Limits computationally determined from genome sequence between P{lacW}OstStt3j2D9 and P{PZ}Aats-gln05461
Experimentally Determined Cytological Location
Cytogenetic map Notes References 96B19-96C6     (So, 2000.4.28) 96B19-96C6     (Sarov-Blat et al., 2000)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\to for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) to-RA FBtr0084810  NM_079773   1038   249
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein to-PA   FBpp0084185   27.3   249   7.93     NP_524497   AAF56425
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Odorant binding protein (IPR004272) Hormone binding (IPR013053)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF56425   AF261748 AAF79960   AI064306   AI107005   AI107767   AI109754   AI114099   AI238846   AI402015   AI403044   AI403166   AI404340   AI405970   AI513380   AY122096 AAM52608   AY232143   CO320972   EC067297   EL869928   EL869929   EL869930   EL869931   EL880901
UniProtKB/Swiss-Prot	Q9VBV3
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0039298    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0039298 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of no expression detected. Peak expression observed in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0039298 expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    3 embryo 20-22hr    28 embryo 22-24hr    46 larva L1    73 larva L2    11 larva L3 12hr old    116 larva L3 puffstage 1-2    208 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    0 white prepupae new    4 white prepupae 12hr    149 white prepupae 24hr    41 pupae 2d postWPP    20 pupae 3d postWPP    7 pupae 4d postWPP    64 adult male 01day    3125 adult male 05day    10408 adult male 30day    19506 adult female 01day    1130 adult female 05day    925 adult female 30day    1673 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    3 embryo 20-22hr    28 embryo 22-24hr    46 larva L1    73 larva L2    11 larva L3 12hr old  (116) larva L3 puffstage 1-2  (208) larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    0 white prepupae new    4 white prepupae 12hr  (149) white prepupae 24hr    41 pupae 2d postWPP    20 pupae 3d postWPP    7 pupae 4d postWPP    64 adult male 01day  (3125) adult male 05day  (10408) adult male 30day  (19506) adult female 01day  (1130) adult female 05day  (925) adult female 30day  (1673) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    3 embryo 20-22hr    28 embryo 22-24hr    46 larva L1    73 larva L2    11 larva L3 12hr old    116 larva L3 puffstage 1-2    208 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    0 white prepupae new    4 white prepupae 12hr    149 white prepupae 24hr    41 pupae 2d postWPP    20 pupae 3d postWPP    7 pupae 4d postWPP    64 adult male 01day  (3125) adult male 05day  (10408) adult male 30day  (19506) adult female 01day    1130 adult female 05day    925 adult female 30day  (1673) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    3 embryo 20-22hr    28 embryo 22-24hr    46 larva L1    73 larva L2    11 larva L3 12hr old    116 larva L3 puffstage 1-2    208 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    0 white prepupae new    4 white prepupae 12hr    149 white prepupae 24hr    41 pupae 2d postWPP    20 pupae 3d postWPP    7 pupae 4d postWPP    64 adult male 01day    3125 adult male 05day  10408 adult male 30day  (19506) adult female 01day    1130 adult female 05day    925 adult female 30day    1673 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    3 embryo 20-22hr    28 embryo 22-24hr    46 larva L1    73 larva L2    11 larva L3 12hr old    116 larva L3 puffstage 1-2    208 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    0 white prepupae new    4 white prepupae 12hr    149 white prepupae 24hr    41 pupae 2d postWPP    20 pupae 3d postWPP    7 pupae 4d postWPP    64 adult male 01day    3125 adult male 05day    10408 adult male 30day    19506 adult female 01day    1130 adult female 05day    925 adult female 30day    1673 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0039298 expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    3 embryo 20-22hr    28 embryo 22-24hr    46 larva L1    73 larva L2    11 larva L3 12hr old    116 larva L3 puffstage 1-2    208 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    0 white prepupae new    4 white prepupae 12hr    149 white prepupae 24hr    41 pupae 2d postWPP    20 pupae 3d postWPP    7 pupae 4d postWPP    64 adult male 01day    3125 adult male 05day    10408 adult male 30day    19506 adult female 01day    1130 adult female 05day    925 adult female 30day    1673 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    3 embryo 20-22hr    28 embryo 22-24hr    46 larva L1    73 larva L2    11 larva L3 12hr old  116 larva L3 puffstage 1-2  (208) larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    0 white prepupae new    4 white prepupae 12hr  (149) white prepupae 24hr    41 pupae 2d postWPP    20 pupae 3d postWPP    7 pupae 4d postWPP    64 adult male 01day  (3125) adult male 05day  (10408) adult male 30day  (19506) adult female 01day  (1130) adult female 05day  (925) adult female 30day  (1673) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    3 embryo 20-22hr    28 embryo 22-24hr    46 larva L1    73 larva L2    11 larva L3 12hr old    116 larva L3 puffstage 1-2    208 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    0 white prepupae new    4 white prepupae 12hr    149 white prepupae 24hr    41 pupae 2d postWPP    20 pupae 3d postWPP    7 pupae 4d postWPP    64 adult male 01day  (3125) adult male 05day  (10408) adult male 30day  (19506) adult female 01day    1130 adult female 05day    925 adult female 30day  1673 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    3 embryo 20-22hr    28 embryo 22-24hr    46 larva L1    73 larva L2    11 larva L3 12hr old    116 larva L3 puffstage 1-2    208 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    0 white prepupae new    4 white prepupae 12hr    149 white prepupae 24hr    41 pupae 2d postWPP    20 pupae 3d postWPP    7 pupae 4d postWPP    64 adult male 01day    3125 adult male 05day  10408 adult male 30day  19506 adult female 01day    1130 adult female 05day    925 adult female 30day    1673 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    3 embryo 20-22hr    28 embryo 22-24hr    46 larva L1    73 larva L2    11 larva L3 12hr old    116 larva L3 puffstage 1-2    208 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    0 white prepupae new    4 white prepupae 12hr    149 white prepupae 24hr    41 pupae 2d postWPP    20 pupae 3d postWPP    7 pupae 4d postWPP    64 adult male 01day    3125 adult male 05day    10408 adult male 30day    19506 adult female 01day    1130 adult female 05day    925 adult female 30day    1673 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0039298    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0039298 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult crop, adult midgut, adult hindgut, larval trachea. Expression at moderate levels in the following post-embryonic organs or tissues: larval hindgut, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0039298 expression level Tissue   Expression Level Larval Central Nervous System    1.375 Larval Midgut    5 Larval Hindgut    254.4 Larval Malpighian Tubules    5.5 Larval Fat Body    4.3 Larval Salivary Gland    6.2 Larval Trachea    1044.925 Larval Carcass no informative data Adult Head    887.9 Adult Eye    581.725 Adult Brain    38.2 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    972.1 Adult Midgut    810 Adult Hindgut    1297.1 Adult Malpighian Tubules no informative data Adult Fat Body    9.8 Adult Salivary Gland no informative data Adult Heart    29.175 Adult VirginFemale Spermatheca    5.2 Adult InseminatedFemale Spermatheca    4.7 Adult Ovary    1.1 Adult Testis    5.3 Adult Male Accessory Gland no informative data Adult Carcass    200.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    1.375 Larval Midgut    5 Larval Hindgut    254.4 Larval Malpighian Tubules    5.5 Larval Fat Body    4.3 Larval Salivary Gland    6.2 Larval Trachea  (1044.925) Larval Carcass no informative data Adult Head  (887.9) Adult Eye  (581.725) Adult Brain    38.2 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop  (972.1) Adult Midgut  (810) Adult Hindgut  (1297.1) Adult Malpighian Tubules no informative data Adult Fat Body    9.8 Adult Salivary Gland no informative data Adult Heart    29.175 Adult VirginFemale Spermatheca    5.2 Adult InseminatedFemale Spermatheca    4.7 Adult Ovary    1.1 Adult Testis    5.3 Adult Male Accessory Gland no informative data Adult Carcass    200.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    1.375 Larval Midgut    5 Larval Hindgut    254.4 Larval Malpighian Tubules    5.5 Larval Fat Body    4.3 Larval Salivary Gland    6.2 Larval Trachea  1044.925 Larval Carcass no informative data Adult Head    887.9 Adult Eye    581.725 Adult Brain    38.2 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    972.1 Adult Midgut    810 Adult Hindgut  (1297.1) Adult Malpighian Tubules no informative data Adult Fat Body    9.8 Adult Salivary Gland no informative data Adult Heart    29.175 Adult VirginFemale Spermatheca    5.2 Adult InseminatedFemale Spermatheca    4.7 Adult Ovary    1.1 Adult Testis    5.3 Adult Male Accessory Gland no informative data Adult Carcass    200.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1.375 Larval Midgut    5 Larval Hindgut    254.4 Larval Malpighian Tubules    5.5 Larval Fat Body    4.3 Larval Salivary Gland    6.2 Larval Trachea    1044.925 Larval Carcass no informative data Adult Head    887.9 Adult Eye    581.725 Adult Brain    38.2 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    972.1 Adult Midgut    810 Adult Hindgut    1297.1 Adult Malpighian Tubules no informative data Adult Fat Body    9.8 Adult Salivary Gland no informative data Adult Heart    29.175 Adult VirginFemale Spermatheca    5.2 Adult InseminatedFemale Spermatheca    4.7 Adult Ovary    1.1 Adult Testis    5.3 Adult Male Accessory Gland no informative data Adult Carcass    200.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0039298 expression level Tissue   Expression Level Larval Central Nervous System    1.375 Larval Midgut    5 Larval Hindgut    254.4 Larval Malpighian Tubules    5.5 Larval Fat Body    4.3 Larval Salivary Gland    6.2 Larval Trachea    1044.925 Larval Carcass no informative data Adult Head    887.9 Adult Eye    581.725 Adult Brain    38.2 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    972.1 Adult Midgut    810 Adult Hindgut    1297.1 Adult Malpighian Tubules no informative data Adult Fat Body    9.8 Adult Salivary Gland no informative data Adult Heart    29.175 Adult VirginFemale Spermatheca    5.2 Adult InseminatedFemale Spermatheca    4.7 Adult Ovary    1.1 Adult Testis    5.3 Adult Male Accessory Gland no informative data Adult Carcass    200.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    1.375 Larval Midgut    5 Larval Hindgut    254.4 Larval Malpighian Tubules    5.5 Larval Fat Body    4.3 Larval Salivary Gland    6.2 Larval Trachea  (1044.925) Larval Carcass no informative data Adult Head  (887.9) Adult Eye  581.725 Adult Brain    38.2 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop  (972.1) Adult Midgut  810 Adult Hindgut  (1297.1) Adult Malpighian Tubules no informative data Adult Fat Body    9.8 Adult Salivary Gland no informative data Adult Heart    29.175 Adult VirginFemale Spermatheca    5.2 Adult InseminatedFemale Spermatheca    4.7 Adult Ovary    1.1 Adult Testis    5.3 Adult Male Accessory Gland no informative data Adult Carcass    200.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    1.375 Larval Midgut    5 Larval Hindgut    254.4 Larval Malpighian Tubules    5.5 Larval Fat Body    4.3 Larval Salivary Gland    6.2 Larval Trachea  1044.925 Larval Carcass no informative data Adult Head    887.9 Adult Eye    581.725 Adult Brain    38.2 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    972.1 Adult Midgut    810 Adult Hindgut  1297.1 Adult Malpighian Tubules no informative data Adult Fat Body    9.8 Adult Salivary Gland no informative data Adult Heart    29.175 Adult VirginFemale Spermatheca    5.2 Adult InseminatedFemale Spermatheca    4.7 Adult Ovary    1.1 Adult Testis    5.3 Adult Male Accessory Gland no informative data Adult Carcass    200.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1.375 Larval Midgut    5 Larval Hindgut    254.4 Larval Malpighian Tubules    5.5 Larval Fat Body    4.3 Larval Salivary Gland    6.2 Larval Trachea    1044.925 Larval Carcass no informative data Adult Head    887.9 Adult Eye    581.725 Adult Brain    38.2 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    972.1 Adult Midgut    810 Adult Hindgut    1297.1 Adult Malpighian Tubules no informative data Adult Fat Body    9.8 Adult Salivary Gland no informative data Adult Heart    29.175 Adult VirginFemale Spermatheca    5.2 Adult InseminatedFemale Spermatheca    4.7 Adult Ovary    1.1 Adult Testis    5.3 Adult Male Accessory Gland no informative data Adult Carcass    200.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass no informative data Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion no informative data Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules no informative data Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    887.9   NA  Eye    581.725   NA  Brain    38.2   1.375  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    no informative data   NA  Crop    972.1   5  Midgut    810   254.4  Hindgut    1297.1   5.5  Malpighian Tubules    no informative data   4.3  Fat Body    9.8   6.2  Salivary Gland    no informative data   NA  Heart    29.175   1044.925  Trachea    NA   NA  VirginFemale Spermatheca    5.2   NA  InseminatedFemale Spermatheca    4.7   NA  Ovary    1.1   NA  Testis    5.3   NA  Male Accessory Gland    no informative data   no informative data  Carcass    200.2 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039298 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11853-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele semi-viable to1 viable toc00632 Sterility Allele fertile toc00632 Other Phenotypes Allele circadian rhythm defective to1 feeding behavior defective | adult stage to1 Phenotype manifest in Allele
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of to Class Mutagen Stocks Known lesion toc00632 piggyBac transposase 2 -- to+t6.4 0 Yes to1 0 Yes
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of to Class Mutagen Stocks Known lesion toGD1195 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes toKK103518 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes toScer\UAS.cZa in vitro construct - regulatory fusion 1 Yes toGD15283 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes toScer\UAS.cLa in vitro construct - regulatory fusion 0 Yes toScer\UAS.cSBa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)FDD-0089346 (DrosDel Project, 2008.11.14) Df(3R)FDD-0247625 (DrosDel Project, 2008.11.14) Df(3R)FDD-0247627 (DrosDel Project, 2008.11.14)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1195} NA P{GD15283} NA P{KK103518} NA P{UAS-to.L} NA P{UAS-to.Z} NA P{UAS-to} NA reporter construct P{to21e-lacZ} No P{to21-lacZ} No P{to80x3-lacZ} No characterization construct P{to80ex3-luc} NA P{to80x3-luc} NA P{to-GAL4.D} NA P{to-luc.S} NA P{to-luc.ΔE} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{PB}toc00632 NA
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
	There is no information supporting a molecular function term for this gene. (Based on a review of available data before: 2006)
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
adult feeding behavior inferred from mutant phenotype (Wong et al., 2009) behavioral response to starvation inferred from mutant phenotype (assigned by UniProtKB) (Sarov-Blat et al., 2000) circadian rhythm inferred from expression pattern (So et al., 2000) male courtship behavior inferred from genetic interaction with fru AND inferred from mutant phenotype (Dauwalder et al., 2002)
Cellular Component
CV term Evidence References
extracellular region inferred from direct assay (assigned by UniProtKB) (Sarov-Blat et al., 2000)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
circadian rhythm non-traceable author statement (Sokolowski, 2001) traceable author statement (Panda et al., 2002, Hendricks, 2003) feeding behavior non-traceable author statement (Sokolowski, 2001) traceable author statement (So et al., 2000, Hendricks, 2003) mating behavior traceable author statement (Anholt, 2004) response to starvation traceable author statement (Stanewsky, 2003) rhythmic behavior traceable author statement (Stanewsky, 2003)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions to allele Gene References to1 fru (Dauwalder et al., 2002)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67955 DroID - A comprehensive database of gene and protein interactions. • FBgn0039298 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43036
Orthologs
Genome-wide drosophilid orthologs	Dana\GF17553 Dere\GG11379 Dgri\GH17381 Dmoj\GI23925 Dper\GL11988 Dpse\GA11237 Dsec\GM17822 Dsim\GD21190 Dvir\GJ24018 Dwil\GK13451 Dyak\to
Curated drosophilid orthologs	Dpse\GA11237   Dyak\to
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL011966-PA Aedes aegypti (mosquito) AGAP004262-PA Anopheles gambiae (mosquito) AGAP012703-PA Anopheles gambiae (mosquito) BGIBMGA001324-PA Bombyx mori (silk worm) BGIBMGA001325-PA Bombyx mori (silk worm) CPIJ015482 Culex pipens (mosquito) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0067921 FBgn0215459 FBgn0211106 FBgn0211105 FBgn0192641 FBgn0172729 FBgn0071291 FBgn0149596 FBgn0146650 FBgn0124851 FBgn0122211 FBgn0103679 FBgn0094571 CPIJ015482 BGIBMGA011552 BGIBMGA011553 BGIBMGA001325 BGIBMGA001308 ACYPI001245 AGAP012703 AGAP004262 AAEL011966 PHUM210810 PHUM595820 GLEAN_15843
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	27646 y1 w*; P{UAS-to.Z}2A 10202 w1118; PBac{PB}toc00632
Harvard	- PBac{PB}toc00632
VDRC	v100079 P{KK103518}VIE-260B v51462 w1118; P{GD1195}v51462 v51463 w1118; P{GD1195}v51463
Genomic Clones ( 3 )
	BACR06L08 BACR10P10 BACR17E12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 16 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH05615
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH04677 GH06283 GH09067 GH10779 GH14970 GH22404 GH22550 GH24001 GH26136 GH26565
Other clones	184537 EK289451 IP02063 IP02064 IP10729
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0039298 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43036
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: to CG11853 (FlyBase, 1996-)
Source for database merge of
Additional comments	Source for identity of to CG11853 was sequence comparison (date:000721). (FlyBase, 1996-)
Other Comments
	to functions in courtship. to does not play a developmental role but has a physiological role in adults. (Lazareva et al., 2007) to is present in the haemolymph of adult males but not females and acts as a secreted protein. (Lazareva et al., 2007) to is required for normal levels of male courtship behaviour and might have a role in integrating information about the organism's sex, nutritional status, and circadian cycle to affect male behaviour. (Dauwalder et al., 2002) Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days. Shows significant change of expression pattern in circadian mutant background; increased expression in per01, tim01 and decreased expression in ClkJrk background. (Claridge-Chang et al., 2001) Identified as a gene with significant level of mRNA cycling as assessed by expression analysis using high density oligonucleotide arrays with probe generated from adult heads harvested over six time points over the course of a day. (McDonald and Rosbash, 2001) to may participate in a novel circadian output pathway that conveys temporal and food status information to feeding-relevant metabolisms and activity. (Sarov-Blat et al., 2000) to is a clock regulated output gene. (So et al., 2000)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079773 RefSeq (Proteins) • NP_524497 DDBJ / EMBL / GenBank • AAF56425 AAF79960 AAM52608 AF261748 AI107767 AI402015 AY122096 Entrez Gene - A searchable database of RefSeq genes. • 43036 UniProtKB/Swiss-Prot • Q9VBV3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Odorant binding protein (IPR004272) Hormone binding (IPR013053)
Linkouts
	BioGRID - A database of protein and genetic interactions • 67955 DroID - A comprehensive database of gene and protein interactions. • FBgn0039298 DRSC - Results from RNAi screens. • FBgn0039298 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039298 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11853-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0039298 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43036 InParanoid A subset of ortholog calls from InParanoid. • AAEL011966-PA Aedes aegypti (mosquito) AGAP004262-PA Anopheles gambiae (mosquito) AGAP012703-PA Anopheles gambiae (mosquito) BGIBMGA001324-PA Bombyx mori (silk worm) BGIBMGA001325-PA Bombyx mori (silk worm) CPIJ015482 Culex pipens (mosquito) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /hjmuller/takeout1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43036 modMine - Data generated by the modENCODE project. • FBgn0039298 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0067921 FBgn0215459 FBgn0211106 FBgn0211105 FBgn0192641 FBgn0172729 FBgn0071291 FBgn0149596 FBgn0146650 FBgn0124851 FBgn0122211 FBgn0103679 FBgn0094571 CPIJ015482 BGIBMGA011552 BGIBMGA011553 BGIBMGA001325 BGIBMGA001308 ACYPI001245 AGAP012703 AGAP004262 AAEL011966 PHUM210810 PHUM595820 GLEAN_15843
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	CG11853 (Apidianakis et al., 2005, McDonald and Rosbash, 2001, Keleman et al., 2009.8.5) CT33074 (Ceriani et al., 2002) to (Benito et al., 2010, Lazareva et al., 2007, Domazet-Loso and Tautz, 2003, Goldman and Arbeitman, 2007, Haerty et al., 2007, Allen and Spradling, 2008, Zheng and Sehgal, 2009.6.26, Meunier et al., 2007, Ruedi and Hughes, 2009, Xu et al., 2008, Terashima and Bownes, 2005, Kim et al., 2010, Dalton et al., 2010)
Name Synonym	Takeout (Pedersen et al., 2008, Lazareva et al., 2007) takeout (So, 2000.4.28, Kadener et al., 2006, Benito et al., 2010, Hoxha et al., 2008, Goldman and Arbeitman, 2007, Allen and Spradling, 2008, Wong et al., 2009, Meunier et al., 2007, Ruedi and Hughes, 2009, Xu et al., 2008, Kim et al., 2010, Terashima and Bownes, 2005, Kim et al., 2010) take-out (Virágh et al., 2007)
Secondary FlyBase IDs
References ( 61 )
Generate a list of	All references relating to this gene ( 61 )
List References by type	Research paper  ( 31 ) Supplementary material  ( 1 ) Review  ( 9 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 7 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 4 ) Letter  ( 1 )
Recent research papers ( 6 )
	Vanaphan et al., 2012, Gene 491(2): 142--148 Diversification of takeout, a male-biased gene family in Drosophila. [FBrf0216815] Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Benito et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(6): 2544--2549 The circadian output gene takeout is regulated by Pdp1{varepsilon}. [FBrf0209901] Dalton et al., 2010, BMC Genomics 11: 541 Dynamic, mating-induced gene expression changes in female head and brain tissues of Drosophila melanogaster. [FBrf0212122] Kim et al., 2010, Mol. Cells 29(1): 93--98 Blood-brain barrier defects associated with Rbp9 mutation. [FBrf0210543] Kim et al., 2010, Exp. Gerontol. 45(12): 984--987 Enhancement of stress resistances and downregulation of Imd pathway by lower developmental temperature in Drosophila melanogaster. [FBrf0212401] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...