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Gene Dmel\CG11858

General Information
Symbol	Dmel\CG11858	Species	D. melanogaster
Name		Annotation symbol	CG11858
Feature type	protein_coding_gene	FlyBase ID	FBgn0039305
Gene Model Status	Current	Stock availability	5 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	96C8-96C8	Sequence location	3R:21,088,463..21,089,014 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG11858 (FBgn0039305). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: peptidyl-prolyl cis-trans isomerase activity. The biological processes in which it is involved are not known. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Peptidyl-prolyl cis-trans isomerase, PpiC-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1633856_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG11858. Gene sequence location is 3R:21088463..21089014.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 96C8-96C8   Limits computationally determined from genome sequence between P{lacW}OstStt3j2D9 and P{PZ}Aats-gln05461
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG11858 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG11858-RA FBtr0084815  NM_143107   493   130
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG11858-PA   FBpp0084190   13.9   130   10.38     NP_651364   AAF56433
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Peptidyl-prolyl cis-trans isomerase, PpiC-type (IPR000297)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF56433   AY071761 AAL49383   BI626094   BI629085   BI638096   EC051051   EC051052   EC052065   EC055065   EC055500   EC056575   EC056621   EV585880   GH941779   GH944359   GH945132   GH949429   GH950115   GH951205   GH951876   GH953761   GH954804   GH962551   GH963487   GH965184   GH967063   GH967798   GH968606   GH969796   GH969909   GH970657   GH971612   GH972710   GH974559   GH975101   GH976943   GH978203   GH980562   GH980904   GH982241   GH982548
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VBU4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic/larval midgut   (Fisher et al., 2012) embryonic/larval muscle system   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    366.7 Larval Midgut    84 Larval Hindgut    145.5 Larval Malpighian Tubules    138.5 Larval Fat Body    137.3 Larval Salivary Gland    239.7 Larval Trachea    239.65 Larval Carcass    162.2 Adult Head    162.6 Adult Eye    135.85 Adult Brain    139.2 Adult Thoracic-Abdominal Ganglion    141.2 Adult Crop    112.6 Adult Midgut    126.5 Adult Hindgut    109.5 Adult Malpighian Tubules    136.9 Adult Fat Body    195.7 Adult Salivary Gland    119.4 Adult Heart    133.075 Adult VirginFemale Spermatheca    274.9 Adult InseminatedFemale Spermatheca    262.5 Adult Ovary    227.7 Adult Testis    90.3 Adult Male Accessory Gland    272.4 Adult Carcass    157.5 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    366.7 Larval Midgut    84 Larval Hindgut    145.5 Larval Malpighian Tubules    138.5 Larval Fat Body    137.3 Larval Salivary Gland    239.7 Larval Trachea    239.65 Larval Carcass    162.2 Adult Head    162.6 Adult Eye    135.85 Adult Brain    139.2 Adult Thoracic-Abdominal Ganglion    141.2 Adult Crop    112.6 Adult Midgut    126.5 Adult Hindgut    109.5 Adult Malpighian Tubules    136.9 Adult Fat Body    195.7 Adult Salivary Gland    119.4 Adult Heart    133.075 Adult VirginFemale Spermatheca    274.9 Adult InseminatedFemale Spermatheca    262.5 Adult Ovary    227.7 Adult Testis    90.3 Adult Male Accessory Gland    272.4 Adult Carcass    157.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    366.7 Larval Midgut    84 Larval Hindgut    145.5 Larval Malpighian Tubules    138.5 Larval Fat Body    137.3 Larval Salivary Gland    239.7 Larval Trachea    239.65 Larval Carcass    162.2 Adult Head    162.6 Adult Eye    135.85 Adult Brain    139.2 Adult Thoracic-Abdominal Ganglion    141.2 Adult Crop    112.6 Adult Midgut    126.5 Adult Hindgut    109.5 Adult Malpighian Tubules    136.9 Adult Fat Body    195.7 Adult Salivary Gland    119.4 Adult Heart    133.075 Adult VirginFemale Spermatheca    274.9 Adult InseminatedFemale Spermatheca    262.5 Adult Ovary    227.7 Adult Testis    90.3 Adult Male Accessory Gland    272.4 Adult Carcass    157.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    366.7 Larval Midgut    84 Larval Hindgut    145.5 Larval Malpighian Tubules    138.5 Larval Fat Body    137.3 Larval Salivary Gland    239.7 Larval Trachea    239.65 Larval Carcass    162.2 Adult Head    162.6 Adult Eye    135.85 Adult Brain    139.2 Adult Thoracic-Abdominal Ganglion    141.2 Adult Crop    112.6 Adult Midgut    126.5 Adult Hindgut    109.5 Adult Malpighian Tubules    136.9 Adult Fat Body    195.7 Adult Salivary Gland    119.4 Adult Heart    133.075 Adult VirginFemale Spermatheca    274.9 Adult InseminatedFemale Spermatheca    262.5 Adult Ovary    227.7 Adult Testis    90.3 Adult Male Accessory Gland    272.4 Adult Carcass    157.5 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    366.7 Larval Midgut    84 Larval Hindgut    145.5 Larval Malpighian Tubules    138.5 Larval Fat Body    137.3 Larval Salivary Gland    239.7 Larval Trachea    239.65 Larval Carcass    162.2 Adult Head    162.6 Adult Eye    135.85 Adult Brain    139.2 Adult Thoracic-Abdominal Ganglion    141.2 Adult Crop    112.6 Adult Midgut    126.5 Adult Hindgut    109.5 Adult Malpighian Tubules    136.9 Adult Fat Body    195.7 Adult Salivary Gland    119.4 Adult Heart    133.075 Adult VirginFemale Spermatheca    274.9 Adult InseminatedFemale Spermatheca    262.5 Adult Ovary    227.7 Adult Testis    90.3 Adult Male Accessory Gland    272.4 Adult Carcass    157.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    366.7 Larval Midgut    84 Larval Hindgut    145.5 Larval Malpighian Tubules    138.5 Larval Fat Body    137.3 Larval Salivary Gland    239.7 Larval Trachea    239.65 Larval Carcass    162.2 Adult Head    162.6 Adult Eye    135.85 Adult Brain    139.2 Adult Thoracic-Abdominal Ganglion    141.2 Adult Crop    112.6 Adult Midgut    126.5 Adult Hindgut    109.5 Adult Malpighian Tubules    136.9 Adult Fat Body    195.7 Adult Salivary Gland    119.4 Adult Heart    133.075 Adult VirginFemale Spermatheca    274.9 Adult InseminatedFemale Spermatheca    262.5 Adult Ovary    227.7 Adult Testis    90.3 Adult Male Accessory Gland    272.4 Adult Carcass    157.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    366.7 Larval Midgut    84 Larval Hindgut    145.5 Larval Malpighian Tubules    138.5 Larval Fat Body    137.3 Larval Salivary Gland    239.7 Larval Trachea    239.65 Larval Carcass    162.2 Adult Head    162.6 Adult Eye    135.85 Adult Brain    139.2 Adult Thoracic-Abdominal Ganglion    141.2 Adult Crop    112.6 Adult Midgut    126.5 Adult Hindgut    109.5 Adult Malpighian Tubules    136.9 Adult Fat Body    195.7 Adult Salivary Gland    119.4 Adult Heart    133.075 Adult VirginFemale Spermatheca    274.9 Adult InseminatedFemale Spermatheca    262.5 Adult Ovary    227.7 Adult Testis    90.3 Adult Male Accessory Gland    272.4 Adult Carcass    157.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    366.7 Larval Midgut    84 Larval Hindgut    145.5 Larval Malpighian Tubules    138.5 Larval Fat Body    137.3 Larval Salivary Gland    239.7 Larval Trachea    239.65 Larval Carcass    162.2 Adult Head    162.6 Adult Eye    135.85 Adult Brain    139.2 Adult Thoracic-Abdominal Ganglion    141.2 Adult Crop    112.6 Adult Midgut    126.5 Adult Hindgut    109.5 Adult Malpighian Tubules    136.9 Adult Fat Body    195.7 Adult Salivary Gland    119.4 Adult Heart    133.075 Adult VirginFemale Spermatheca    274.9 Adult InseminatedFemale Spermatheca    262.5 Adult Ovary    227.7 Adult Testis    90.3 Adult Male Accessory Gland    272.4 Adult Carcass    157.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    162.6   NA  Eye    135.85   NA  Brain    139.2   366.7  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    141.2   NA  Crop    112.6   84  Midgut    126.5   145.5  Hindgut    109.5   138.5  Malpighian Tubules    136.9   137.3  Fat Body    195.7   239.7  Salivary Gland    no informative data   NA  Heart    133.075   239.65  Trachea    NA   NA  VirginFemale Spermatheca    274.9   NA  InseminatedFemale Spermatheca    262.5   NA  Ovary    227.7   NA  Testis    90.3   NA  Male Accessory Gland    272.4   162.2  Carcass    157.5 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    25 central nervous system, pupae P8    14 head, virgin 1-day female    9 head, virgin 4-day female    11 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    9 head, mated 20-day female    3 head, mated 1-day male    15 head, mated 4-day male    11 head, mated 20-day male    10 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    7 digestive system, 4-day adult    9 digestive system, 20-day adult    8 fat body, larvae L3 wandering    5 fat body, white prepupae    8 fat body, pupae P8    0 carcass, larvae L3 wandering    16 carcass, 1-day adult    6 carcass, 4-day adult    6 carcass, 20-day adult    5 ovary, virgin 4-day female    15 ovary, mated 4-day female    28 testis, mated 4-day male    21 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    25 central nervous system, pupae P8    14 head, virgin 1-day female    9 head, virgin 4-day female    11 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    9 head, mated 20-day female    3 head, mated 1-day male    15 head, mated 4-day male    11 head, mated 20-day male    10 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    7 digestive system, 4-day adult    9 digestive system, 20-day adult    8 fat body, larvae L3 wandering    5 fat body, white prepupae    8 fat body, pupae P8    0 carcass, larvae L3 wandering    16 carcass, 1-day adult    6 carcass, 4-day adult    6 carcass, 20-day adult    5 ovary, virgin 4-day female    15 ovary, mated 4-day female  (28) testis, mated 4-day male    21 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    25 central nervous system, pupae P8    14 head, virgin 1-day female    9 head, virgin 4-day female    11 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    9 head, mated 20-day female    3 head, mated 1-day male    15 head, mated 4-day male    11 head, mated 20-day male    10 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    7 digestive system, 4-day adult    9 digestive system, 20-day adult    8 fat body, larvae L3 wandering    5 fat body, white prepupae    8 fat body, pupae P8    0 carcass, larvae L3 wandering    16 carcass, 1-day adult    6 carcass, 4-day adult    6 carcass, 20-day adult    5 ovary, virgin 4-day female    15 ovary, mated 4-day female    28 testis, mated 4-day male    21 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    25 central nervous system, pupae P8    14 head, virgin 1-day female    9 head, virgin 4-day female    11 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    9 head, mated 20-day female    3 head, mated 1-day male    15 head, mated 4-day male    11 head, mated 20-day male    10 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    7 digestive system, 4-day adult    9 digestive system, 20-day adult    8 fat body, larvae L3 wandering    5 fat body, white prepupae    8 fat body, pupae P8    0 carcass, larvae L3 wandering    16 carcass, 1-day adult    6 carcass, 4-day adult    6 carcass, 20-day adult    5 ovary, virgin 4-day female    15 ovary, mated 4-day female    28 testis, mated 4-day male    21 accessory gland, mated 4-day male    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    25 central nervous system, pupae P8    14 head, virgin 1-day female    9 head, virgin 4-day female    11 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    9 head, mated 20-day female    3 head, mated 1-day male    15 head, mated 4-day male    11 head, mated 20-day male    10 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    7 digestive system, 4-day adult    9 digestive system, 20-day adult    8 fat body, larvae L3 wandering    5 fat body, white prepupae    8 fat body, pupae P8    0 carcass, larvae L3 wandering    16 carcass, 1-day adult    6 carcass, 4-day adult    6 carcass, 20-day adult    5 ovary, virgin 4-day female    15 ovary, mated 4-day female    28 testis, mated 4-day male    21 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    25 central nervous system, pupae P8    14 head, virgin 1-day female    9 head, virgin 4-day female    11 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    9 head, mated 20-day female    3 head, mated 1-day male    15 head, mated 4-day male    11 head, mated 20-day male    10 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    7 digestive system, 4-day adult    9 digestive system, 20-day adult    8 fat body, larvae L3 wandering    5 fat body, white prepupae    8 fat body, pupae P8    0 carcass, larvae L3 wandering    16 carcass, 1-day adult    6 carcass, 4-day adult    6 carcass, 20-day adult    5 ovary, virgin 4-day female    15 ovary, mated 4-day female  28 testis, mated 4-day male    21 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    25 central nervous system, pupae P8    14 head, virgin 1-day female    9 head, virgin 4-day female    11 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    9 head, mated 20-day female    3 head, mated 1-day male    15 head, mated 4-day male    11 head, mated 20-day male    10 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    7 digestive system, 4-day adult    9 digestive system, 20-day adult    8 fat body, larvae L3 wandering    5 fat body, white prepupae    8 fat body, pupae P8    0 carcass, larvae L3 wandering    16 carcass, 1-day adult    6 carcass, 4-day adult    6 carcass, 20-day adult    5 ovary, virgin 4-day female    15 ovary, mated 4-day female    28 testis, mated 4-day male    21 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    25 central nervous system, pupae P8    14 head, virgin 1-day female    9 head, virgin 4-day female    11 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    9 head, mated 20-day female    3 head, mated 1-day male    15 head, mated 4-day male    11 head, mated 20-day male    10 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    7 digestive system, 4-day adult    9 digestive system, 20-day adult    8 fat body, larvae L3 wandering    5 fat body, white prepupae    8 fat body, pupae P8    0 carcass, larvae L3 wandering    16 carcass, 1-day adult    6 carcass, 4-day adult    6 carcass, 20-day adult    5 ovary, virgin 4-day female    15 ovary, mated 4-day female    28 testis, mated 4-day male    21 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    42 embryo 02-04hr    55 embryo 04-06hr    48 embryo 06-08hr    21 embryo 08-10hr    18 embryo 10-12hr    32 embryo 12-14hr    30 embryo 14-16hr    28 embryo 16-18hr    24 embryo 18-20hr    18 embryo 20-22hr    21 embryo 22-24hr    18 larva L1    45 larva L2    49 larva L3 12hr old    33 larva L3 puffstage 1-2    28 larva L3 puffstage 3-6    29 larva L3 puffstage 7-9    31 white prepupae new    28 white prepupae 12hr    25 white prepupae 24hr    31 pupae 2d postWPP    34 pupae 3d postWPP    21 pupae 4d postWPP    13 adult male 01day    16 adult male 05day    16 adult male 30day    14 adult female 01day    35 adult female 05day    46 adult female 30day    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (42) embryo 02-04hr  (55) embryo 04-06hr  (48) embryo 06-08hr    21 embryo 08-10hr    18 embryo 10-12hr  (32) embryo 12-14hr  (30) embryo 14-16hr  (28) embryo 16-18hr    24 embryo 18-20hr    18 embryo 20-22hr    21 embryo 22-24hr    18 larva L1  (45) larva L2  (49) larva L3 12hr old  (33) larva L3 puffstage 1-2  (28) larva L3 puffstage 3-6  (29) larva L3 puffstage 7-9  (31) white prepupae new  (28) white prepupae 12hr    25 white prepupae 24hr  (31) pupae 2d postWPP  (34) pupae 3d postWPP    21 pupae 4d postWPP    13 adult male 01day    16 adult male 05day    16 adult male 30day    14 adult female 01day  (35) adult female 05day  (46) adult female 30day  (45) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    42 embryo 02-04hr    55 embryo 04-06hr    48 embryo 06-08hr    21 embryo 08-10hr    18 embryo 10-12hr    32 embryo 12-14hr    30 embryo 14-16hr    28 embryo 16-18hr    24 embryo 18-20hr    18 embryo 20-22hr    21 embryo 22-24hr    18 larva L1    45 larva L2    49 larva L3 12hr old    33 larva L3 puffstage 1-2    28 larva L3 puffstage 3-6    29 larva L3 puffstage 7-9    31 white prepupae new    28 white prepupae 12hr    25 white prepupae 24hr    31 pupae 2d postWPP    34 pupae 3d postWPP    21 pupae 4d postWPP    13 adult male 01day    16 adult male 05day    16 adult male 30day    14 adult female 01day    35 adult female 05day    46 adult female 30day    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    42 embryo 02-04hr    55 embryo 04-06hr    48 embryo 06-08hr    21 embryo 08-10hr    18 embryo 10-12hr    32 embryo 12-14hr    30 embryo 14-16hr    28 embryo 16-18hr    24 embryo 18-20hr    18 embryo 20-22hr    21 embryo 22-24hr    18 larva L1    45 larva L2    49 larva L3 12hr old    33 larva L3 puffstage 1-2    28 larva L3 puffstage 3-6    29 larva L3 puffstage 7-9    31 white prepupae new    28 white prepupae 12hr    25 white prepupae 24hr    31 pupae 2d postWPP    34 pupae 3d postWPP    21 pupae 4d postWPP    13 adult male 01day    16 adult male 05day    16 adult male 30day    14 adult female 01day    35 adult female 05day    46 adult female 30day    45 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    42 embryo 02-04hr    55 embryo 04-06hr    48 embryo 06-08hr    21 embryo 08-10hr    18 embryo 10-12hr    32 embryo 12-14hr    30 embryo 14-16hr    28 embryo 16-18hr    24 embryo 18-20hr    18 embryo 20-22hr    21 embryo 22-24hr    18 larva L1    45 larva L2    49 larva L3 12hr old    33 larva L3 puffstage 1-2    28 larva L3 puffstage 3-6    29 larva L3 puffstage 7-9    31 white prepupae new    28 white prepupae 12hr    25 white prepupae 24hr    31 pupae 2d postWPP    34 pupae 3d postWPP    21 pupae 4d postWPP    13 adult male 01day    16 adult male 05day    16 adult male 30day    14 adult female 01day    35 adult female 05day    46 adult female 30day    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (42) embryo 02-04hr  (55) embryo 04-06hr  (48) embryo 06-08hr    21 embryo 08-10hr    18 embryo 10-12hr  32 embryo 12-14hr  30 embryo 14-16hr  28 embryo 16-18hr    24 embryo 18-20hr    18 embryo 20-22hr    21 embryo 22-24hr    18 larva L1  (45) larva L2  (49) larva L3 12hr old  (33) larva L3 puffstage 1-2  28 larva L3 puffstage 3-6  29 larva L3 puffstage 7-9  31 white prepupae new  28 white prepupae 12hr    25 white prepupae 24hr  31 pupae 2d postWPP  (34) pupae 3d postWPP    21 pupae 4d postWPP    13 adult male 01day    16 adult male 05day    16 adult male 30day    14 adult female 01day  (35) adult female 05day  (46) adult female 30day  (45) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    42 embryo 02-04hr    55 embryo 04-06hr    48 embryo 06-08hr    21 embryo 08-10hr    18 embryo 10-12hr    32 embryo 12-14hr    30 embryo 14-16hr    28 embryo 16-18hr    24 embryo 18-20hr    18 embryo 20-22hr    21 embryo 22-24hr    18 larva L1    45 larva L2    49 larva L3 12hr old    33 larva L3 puffstage 1-2    28 larva L3 puffstage 3-6    29 larva L3 puffstage 7-9    31 white prepupae new    28 white prepupae 12hr    25 white prepupae 24hr    31 pupae 2d postWPP    34 pupae 3d postWPP    21 pupae 4d postWPP    13 adult male 01day    16 adult male 05day    16 adult male 30day    14 adult female 01day    35 adult female 05day    46 adult female 30day    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    42 embryo 02-04hr    55 embryo 04-06hr    48 embryo 06-08hr    21 embryo 08-10hr    18 embryo 10-12hr    32 embryo 12-14hr    30 embryo 14-16hr    28 embryo 16-18hr    24 embryo 18-20hr    18 embryo 20-22hr    21 embryo 22-24hr    18 larva L1    45 larva L2    49 larva L3 12hr old    33 larva L3 puffstage 1-2    28 larva L3 puffstage 3-6    29 larva L3 puffstage 7-9    31 white prepupae new    28 white prepupae 12hr    25 white prepupae 24hr    31 pupae 2d postWPP    34 pupae 3d postWPP    21 pupae 4d postWPP    13 adult male 01day    16 adult male 05day    16 adult male 30day    14 adult female 01day    35 adult female 05day    46 adult female 30day    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    35 Schneider line 2 Sg4    34 embryonic 1182-4H    23 embryonic GM2    7 embryonic Kc167    9 embryonic S1    13 embryonic S3    19 leg disc CME L1    31 wing disc CME-W2    34 wing disc ML-DmD8    19 wing disc ML-DmD9    24 wing disc ML-DmD16-c3    32 wing disc ML-DmD21    69 wing disc ML-DmD32    20 haltere disc ML-DmD17-c3    24 eye-antennal disc ML-DmD11    27 antennal disc ML-DmD20-c5    36 mixed discs ML-DmD4-c1    46 CNS ML-DmBG1-c1    40 CNS ML-DmBG2-c2    19 tumorous blood cells mbn2    7 ovary fGS/OSS    23 ovary OSC    13 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (35) Schneider line 2 Sg4  (34) embryonic 1182-4H    23 embryonic GM2    7 embryonic Kc167    9 embryonic S1    13 embryonic S3    19 leg disc CME L1  (31) wing disc CME-W2  (34) wing disc ML-DmD8    19 wing disc ML-DmD9    24 wing disc ML-DmD16-c3  (32) wing disc ML-DmD21  (69) wing disc ML-DmD32    20 haltere disc ML-DmD17-c3    24 eye-antennal disc ML-DmD11  (27) antennal disc ML-DmD20-c5  (36) mixed discs ML-DmD4-c1  (46) CNS ML-DmBG1-c1  (40) CNS ML-DmBG2-c2    19 tumorous blood cells mbn2    7 ovary fGS/OSS    23 ovary OSC    13 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    35 Schneider line 2 Sg4    34 embryonic 1182-4H    23 embryonic GM2    7 embryonic Kc167    9 embryonic S1    13 embryonic S3    19 leg disc CME L1    31 wing disc CME-W2    34 wing disc ML-DmD8    19 wing disc ML-DmD9    24 wing disc ML-DmD16-c3    32 wing disc ML-DmD21    69 wing disc ML-DmD32    20 haltere disc ML-DmD17-c3    24 eye-antennal disc ML-DmD11    27 antennal disc ML-DmD20-c5    36 mixed discs ML-DmD4-c1    46 CNS ML-DmBG1-c1    40 CNS ML-DmBG2-c2    19 tumorous blood cells mbn2    7 ovary fGS/OSS    23 ovary OSC    13 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    35 Schneider line 2 Sg4    34 embryonic 1182-4H    23 embryonic GM2    7 embryonic Kc167    9 embryonic S1    13 embryonic S3    19 leg disc CME L1    31 wing disc CME-W2    34 wing disc ML-DmD8    19 wing disc ML-DmD9    24 wing disc ML-DmD16-c3    32 wing disc ML-DmD21    69 wing disc ML-DmD32    20 haltere disc ML-DmD17-c3    24 eye-antennal disc ML-DmD11    27 antennal disc ML-DmD20-c5    36 mixed discs ML-DmD4-c1    46 CNS ML-DmBG1-c1    40 CNS ML-DmBG2-c2    19 tumorous blood cells mbn2    7 ovary fGS/OSS    23 ovary OSC    13 ovary OSS    13 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    35 Schneider line 2 Sg4    34 embryonic 1182-4H    23 embryonic GM2    7 embryonic Kc167    9 embryonic S1    13 embryonic S3    19 leg disc CME L1    31 wing disc CME-W2    34 wing disc ML-DmD8    19 wing disc ML-DmD9    24 wing disc ML-DmD16-c3    32 wing disc ML-DmD21    69 wing disc ML-DmD32    20 haltere disc ML-DmD17-c3    24 eye-antennal disc ML-DmD11    27 antennal disc ML-DmD20-c5    36 mixed discs ML-DmD4-c1    46 CNS ML-DmBG1-c1    40 CNS ML-DmBG2-c2    19 tumorous blood cells mbn2    7 ovary fGS/OSS    23 ovary OSC    13 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (35) Schneider line 2 Sg4  (34) embryonic 1182-4H    23 embryonic GM2    7 embryonic Kc167    9 embryonic S1    13 embryonic S3    19 leg disc CME L1  31 wing disc CME-W2  (34) wing disc ML-DmD8    19 wing disc ML-DmD9    24 wing disc ML-DmD16-c3  32 wing disc ML-DmD21  (69) wing disc ML-DmD32    20 haltere disc ML-DmD17-c3    24 eye-antennal disc ML-DmD11  27 antennal disc ML-DmD20-c5  (36) mixed discs ML-DmD4-c1  (46) CNS ML-DmBG1-c1  (40) CNS ML-DmBG2-c2    19 tumorous blood cells mbn2    7 ovary fGS/OSS    23 ovary OSC    13 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    35 Schneider line 2 Sg4    34 embryonic 1182-4H    23 embryonic GM2    7 embryonic Kc167    9 embryonic S1    13 embryonic S3    19 leg disc CME L1    31 wing disc CME-W2    34 wing disc ML-DmD8    19 wing disc ML-DmD9    24 wing disc ML-DmD16-c3    32 wing disc ML-DmD21    69 wing disc ML-DmD32    20 haltere disc ML-DmD17-c3    24 eye-antennal disc ML-DmD11    27 antennal disc ML-DmD20-c5    36 mixed discs ML-DmD4-c1    46 CNS ML-DmBG1-c1    40 CNS ML-DmBG2-c2    19 tumorous blood cells mbn2    7 ovary fGS/OSS    23 ovary OSC    13 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    35 Schneider line 2 Sg4    34 embryonic 1182-4H    23 embryonic GM2    7 embryonic Kc167    9 embryonic S1    13 embryonic S3    19 leg disc CME L1    31 wing disc CME-W2    34 wing disc ML-DmD8    19 wing disc ML-DmD9    24 wing disc ML-DmD16-c3    32 wing disc ML-DmD21    69 wing disc ML-DmD32    20 haltere disc ML-DmD17-c3    24 eye-antennal disc ML-DmD11    27 antennal disc ML-DmD20-c5    36 mixed discs ML-DmD4-c1    46 CNS ML-DmBG1-c1    40 CNS ML-DmBG2-c2    19 tumorous blood cells mbn2    7 ovary fGS/OSS    23 ovary OSC    13 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    17 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    17 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    17 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    17 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    17 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    17 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    17 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    17 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    8 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_26 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • RH66629 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039305 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11858-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG11858GD7406 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of CG11858 Class Mutagen Stocks Known lesion CG11858G5418 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG11858 Class Mutagen Stocks Known lesion CG11858GD17319 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG11858GD7406 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG11858KK108489 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG11858NIG.11858R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)FDD-0247625 (DrosDel Project, 2008.11.14) Df(3R)FDD-0247627 (DrosDel Project, 2008.11.14)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7406} NA P{GD17319} NA P{KK108489} NA P{NIG.11858R} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}CG11858G5418 NA
Gene Ontology: Function, Process & Cellular Component ( 1 unique term )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function
CV term Evidence References
peptidyl-prolyl cis-trans isomerase activity inferred from sequence or structural similarity with EMBL:AF143096 (FlyBase, 1992-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG11858 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0039305 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43044
Orthologs
OrthoDB Orthologs (35) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG622B5H Dipteran inclusive ortholog search EOG6NS3N3 Insect inclusive ortholog search EOG6CVF4T Arthropod inclusive ortholog search EOG6MSBG2 Metazoa inclusive ortholog search EOG676XVW
Orthologs in Drosophila Species (EOG622B5H)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG11858     Drosophila simulans   Dsim\GD21195 Y   Drosophila sechellia   Dsec\GM17827 Y   Drosophila erecta   Dere\GG11384 Y   Drosophila yakuba   Dyak\GE23581 Y   Drosophila ananassae   Dana\GF17558 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA11241 Y   Drosophila persimilis   Dper\GL21710 Y   Drosophila willistoni   Dwil\GK12925 Y   Drosophila virilis   Dvir\GJ22713 Y   Drosophila grimshawi   Dgri\GH22285 Y
Orthologs in non-Drosophila Dipterans (EOG6NS3N3)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL000852   Anopheles gambiae Malaria mosquito  Agam\AGAP013296   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ013329
Orthologs in non-Dipteran Insects (EOG6CVF4T)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB43686   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG019441   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH11836   Atta cephalotes Leafcutter ant  Acep\ACEP26208   Camponotus floridanus Florida carpenter ant  Cflo\CFLO22969   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL21368   Linepithema humile Argentine ant  Lhum\LH18668   Pogonomyrmex barbatus Red harvester ant  Pbar\PB13974   Solenopsis invicta Red fire ant  Sinv\SINV10282   Acyrthosiphon pisum Pea aphid  Apim\ACYPI008778   Bombyx mori Silkmoth  Bmor\BGIBMGA007543   Pediculus humanus Human body louse  Phum\PHUM404820   Tribolium castaneum Red flour beetle  Tcas\TC009923
Orthologs in non-Insect Arthropods (EOG6MSBG2)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_299806   Ixodes scapularis Deer tick  Isca\ISCW006091
Orthologs in non-Arthropod Metazoa (EOG676XVW)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\Y48C3A.16   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018786gn   Danio rerio Zebrafish  Drer\pin4   Xenopus tropicalis Western clawed frog  Xtro\pin4   Gallus gallus Domestic chicken  Ggal\PIN4   Mus musculus House mouse  Mmus\Pin4
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD21195 Drosophila sechellia Dsec\GM17827 Drosophila erecta Dere\GG11384 Drosophila yakuba Dyak\GE23581 Drosophila ananassae Dana\GF17558 Drosophila pseudoobscura pseudoobscura Dpse\GA11241 Drosophila persimilis Dper\GL21710 Drosophila willistoni Dwil\GK12925 Drosophila virilis Dvir\GJ22713 Drosophila grimshawi Dgri\GH22285
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	31795 w1118; P{EP}CG11858G5418/TM6C, Sb1
VDRC	v106769 P{KK108489}VIE-260B v31579 w1118 P{GD7406}v31579 v49586 w1118; P{GD17319}v49586 v49585 w1118; P{GD17319}v49585/CyO
Genomic Clones ( 3 )
	BACR06L08 BACR10P10 BACR17E12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 39 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RH66629
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RH57892 SD20302
Other clones	Dmel_dig_006137_0703_3094 EC051051 EC051052 EC052065 EC055065 EC055500 EC056575 EC056621 RP004108061 RP004125258 RP004152680 RP004165877 RP004177021 RP004185779 RP004219953 RP004222850 RP004234492 RP004234634 RP004239681 RP004241767 RP004262358 RP004262404 RP004306658 RP004349777 RP004361329 RP004393506 RP004409657 RP004424246 RP004435720 RP004436598 RP004452120 RP004463165 RP004472438 RP004494333 RP004513881 RP004524531
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0039305 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43044
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG11858 BcDNA:RH66629 (FlyBase, 1996-)
Additional comments	Source for merge of CG11858 BcDNA:RH66629 was TrEMBL update (date:020807). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_143107 RefSeq (Proteins) • NP_651364 DDBJ / EMBL / GenBank • AAF56433 AAL49383 AY071761 BI626094 Entrez Gene - A searchable database of RefSeq genes. • 43044 UniProtKB/TrEMBL • Q9VBU4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Peptidyl-prolyl cis-trans isomerase, PpiC-type (IPR000297) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RH66629
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0039305 DRSC - Results from RNAi screens. • FBgn0039305 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039305 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11858-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0039305 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43044 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43044 modMine - Data generated by the modENCODE project. • FBgn0039305
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	BcDNA:RH66629   CG11858 (Keleman et al., 2009.8.5, Cammarato et al., 2011, Japanese National Institute of Genetics, 2012.5.21)
Name Synonym
Secondary FlyBase IDs
	FBgn0046998
References ( 16 )
Research paper	Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812]
Supplementary material	Cammarato et al., 2011, PLoS ONE 6(4): Table S1. Proteins & Peptides. [FBrf0214682] Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Bellen, 2010.7.14, BDGP_2010_0715.GenExel.xml BDGP_2010_0715.GenExel.xml [FBrf0211255] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] DrosDel Project, 2008.11.14, Deletion FDD-0247627. Deletion FDD-0247627. [FBrf0206147] DrosDel Project, 2008.11.14, Deletion FDD-0247625. Deletion FDD-0247625. [FBrf0206146] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]
FlyBase analysis	FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946] FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]
Stock list	Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY. RNAi stocks available from NIG-FLY. [FBrf0218457]
Website	Fisher et al., 2012, BDGP insitu homepage BDGP insitu homepage [FBrf0219073]
Curated genome annotation	FamiliarityBreedsContempt, 1999.11, [Automatic annotations performed at the Celera Jamboreee.] [Automatic annotations performed at the Celera Jamboreee.] [FBrf0126705]