A Database of Drosophila Genes & Genomes

FB2012_01, released January 20th, 2012
 

Gene Dmel\CG11859

General Information
SymbolDmel\CG11859SpeciesD. melanogaster
NameAnnotation symbolCG11859
Feature typeprotein_coding_geneFlyBase IDFBgn0039306
Gene Model StatusCurrent Stock availability 5 publicly available
Genomic Location
Chromosome (arm)3RRecombination map
Cytogenetic map96C8-96C8Sequence location3R:21,091,566..21,093,479 [+]

Genomic Maps

GBrowse View Help
modENCODE GBrowse
detailed view
hide Summary Information
Automatically generated summary

See sections below for more information
This gene is referred to in FlyBase by the symbol Dmel\CG11859 (FBgn0039306). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: protein kinase activity. There is experimental evidence that it is involved in the biological process: neurogenesis. 4 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; mesothoracic tergum. It has one annotated transcript and one annotated polypeptide. Protein features are: Protein kinase-like domain; RIO kinase, conserved site; RIO-like kinase; RIO2 kinase, winged helix, N-terminal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during early larval stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, adult hindgut, adult Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1630557_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG11859. Gene sequence location is 3R:21091566..21093479.

hide Recent Updates
Description
What does this section display?
This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).
What does this section not display?
This section does not currently display links that were removed or gene model changes.
Update Feed
Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
atom feed
FB2012_01
Sequence features
HFA14413
BKN21901
BKN50532
BKN51075
FB2011_10
All updates Click here to see a list of all updates to this record from FB2010_08 and on.
hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
96C8-96C8  
Limits computationally determined from genome sequence between P{PZ}Aats-gln05461 and P{EP}EP3354  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
hide Gene Model & Products
Please see the GBrowse view of Dmel\CG11859 for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
detailed view FBtr0084866 FBtr0084816 FBtr0306845 FBtr0084817 FBpp0084240 FBpp0084191 FBti0111391 FBti0056836 FBti0005535 FBti0051249
Comments on Gene Model
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
CG11859-RA
FBtr0084816
 NM_143108
  1751
  538
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
CG11859-PA  
FBpp0084191  
61.4  
538  
5.02  
  NP_651365
  AAF56435
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
•
Protein kinase-like domain (IPR011009)
RIO-like kinase (IPR018934)
RIO kinase, conserved site (IPR018935)
RIO2 kinase, winged helix, N-terminal (IPR015285)
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
AE014297
AAF56435
 
BT083465
 
CK660871
 
CO279422
 
CO309551
 
CO316711
 
CZ486024
 
EC064511
 
EC227019
 
EV592453
 
FL502733
 
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
hide Mapped Features
Mapped Features have been reorganized, please see this article for details.
Additional mapped features and mutations can be found on GBrowse or related reports.
Type
Symbol & Location
Additional Notes
References
hide External Data
Linkouts
Crossreferences
hide Expression Data
hideTranscript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
hidePolypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
hide High-Throughput Expression Data
or
Untitled Document detailed view Aats-gln-RA CG11859-RA CR43310-RA CR13656-RA
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
[an error occurred while processing this directive]
modENCODE Temporal Expression Data (Graveley et al., 2011)
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
hide Expression Clusters
A cluster of genes with similar mRNA expression dynamics across development.
(The modENCODE Consortium, 2010)
hide External Data & Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
•
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
•
hide Alleles & Phenotypes
hide Summary of Allele Phenotypes
Lethality
Allele
lethal, with Scer\GAL41407
lethal | pupal stage, with Scer\GAL4pnr-MD237
semi-lethal | pupal stage, with Scer\GAL4pnr-MD237
Other Phenotypes
Allele
neuroanatomy defective | larval stage, with Scer\GAL41407
visible, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
embryonic/larval neuroblast | larval stage, with Scer\GAL41407
ganglion mother cell | larval stage, with Scer\GAL41407
mesothoracic tergum, with Scer\GAL4pnr-MD237
trichogen cell, with Scer\GAL4pnr-MD237
hide Classical Alleles ( 1 )
For All Classical Alleles Show

Allele of CG11859ClassMutagenStocksKnown lesion
CG11859f034571 --
hide Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show

Allele of CG11859ClassMutagenStocksKnown lesion
CG11859GD74073 Yes
CG11859GL002931 Yes
CG11859KK1018500 Yes
hide Aneuploid Aberrations
Disrupted in
(DrosDel Project, 2008.11.14)
hide Transgenic Constructs & Insertions
Transgenic Constructs
Type of construct
Name
Expression data
UAS construct
P{GD7407}
NA
P{KK101850}
NA
P{TRiP.GL00293}
NA
Insertions
Type of insertions
Name
Expression data
miscellaneous insertions
PBac{WH}CG11859f03457
NA
hide Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
hide Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term
Evidence
References
neurogenesis
inferred from mutant phenotype
(Neumüller et al., 2011)
Cellular Component ( 0 terms)
hide Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term
Evidence
References
ATP binding
inferred from electronic annotation with InterPro:IPR015285, InterPro:IPR018934, InterPro:IPR018935
(FlyBase Curators et al., 2004-)
protein kinase activity
non-traceable author statement
(Manning, 2002.11.16)
protein serine/threonine kinase activity
inferred from electronic annotation with InterPro:IPR015285, InterPro:IPR018935
(FlyBase Curators et al., 2004-)
Biological Process
CV term
Evidence
References
protein phosphorylation
inferred from electronic annotation with InterPro:IPR015285
(FlyBase Curators et al., 2004-)
non-traceable author statement
(Manning, 2002.11.16)
Cellular Component ( 0 terms)
hide Sequence Ontology: Class of Gene
nuclear_gene
 
protein_coding_gene
 
hide Interactions & Pathways
hide Summary of Physical Interactions
Protein-protein
Interacting group
Assay
References
hide Summary of Genetic Interactions
Interacts with
Please look at the allele data for full details of the genetic interactions
CG11859 allele
Gene
References
hide External Data
Linkouts
DroID - A comprehensive database of gene and protein interactions.
•
InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.
•
hide Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs
 
Linkouts
InParanoid A subset of ortholog calls from InParanoid.
•
OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs.
•
hide Stocks & Reagents
hide Stocks Listed in FlyBase ( 5 )
Bloomington
35379
y1 sc* v1; P{TRiP.GL00293}attP2
Harvard
-
PBac{WH}CG11859f03457
VDRC
v31580
w1118 P{GD7407}v31580
v47401
w1118; P{GD7407}v47401
v47402
w1118; P{GD7407}v47402/CyO
hide Genomic Clones ( 3 )

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
hide cDNA Clones ( 9 )

Please Note
This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
hide RNAi & Array Information
Linkouts
DRSC - Results from RNAi screens.
•
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
•
hide Antibody Information
hide Other Information
hide Discoverer
hide Etymology
hide Identification
hide Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
hide Other Comments
hide External Crossreferences & Linkouts
Sequence Crossreferences
RefSeq (Transcripts)
•
RefSeq (Proteins)
•
DDBJ / EMBL / GenBank
•
Entrez Gene - A searchable database of RefSeq genes.
•
UniProtKB/TrEMBL
•
Other Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
•
Protein kinase-like domain (IPR011009)
RIO-like kinase (IPR018934)
RIO kinase, conserved site (IPR018935)
RIO2 kinase, winged helix, N-terminal (IPR015285)
Linkouts
DroID - A comprehensive database of gene and protein interactions.
•
DRSC - Results from RNAi screens.
•
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
•
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
•
FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans
•
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
•
InParanoid A subset of ortholog calls from InParanoid.
•
InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.
•
modMine - Data generated by the modENCODE project.
•
OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs.
•
hide Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym
CG11859
(Keleman et al., 2009.8.5, Ni et al., 2011.7.19)
Name Synonym
Secondary FlyBase IDs
hide References ( 12 )
Supplementary material
Neumüller et al., 2011, Cell Stem Cell 8(5):
Supplemental Table S1. [FBrf0214431]
The modENCODE Consortium, 2010, Science 330(6012):
DataS14: Gene co-expression clusters. [FBrf0213979]
Mummery-Widmer et al., 2009, Nature 458(7241):
Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase
Ni et al., 2011.7.19, TRiP germline vector pVALIUM21.
TRiP germline vector pVALIUM21. [FBrf0214641]
Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center
RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510]
Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center
RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327]
FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms.
Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
Manning, 2002.11.16, CG10673probably is a kinase.
CG10673probably is a kinase. [FBrf0151620]
Computer file
DrosDel Project, 2008.11.14, Deletion FDD-0247625.
Deletion FDD-0247625. [FBrf0206146]
Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection.
Genomic mapping of Exelixis insertion collection. [FBrf0184340]
Gene Disruption Project members, 2001-, [title not yet available]
[title not yet available] [FBrf0132177]