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Gene Dmel\CG11891

General Information
Symbol	Dmel\CG11891	Species	D. melanogaster
Name		Annotation symbol	CG11891
Feature type	protein_coding_gene	FlyBase ID	FBgn0039309
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	CG33091
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	96C8-96C8	Sequence location	3R:21,095,953..21,098,989 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG11891 (FBgn0039309). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: transferase activity, transferring phosphorus-containing groups. The biological processes in which it is involved are not known. 5 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: CHK kinase-like; Protein kinase-like domain; Protein of unknown function DUF227. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed within 18-24 hour embryonic stages, at stages throughout the larval period, in adult male stages. This gene is annotated by FlyBase as a dicistronic gene, meaning that some or all of its transcripts encode two or more polypeptide-coding open reading frames (ORFs) , with each ORF assigned to a different gene. The distribution of RNA-Seq coverage data amongst the different encoded genes cannot be determined. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult midgut, larval/adult Malpighian tubules. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult central nervous system, adult hindgut. Comments on Affy2 ProbeSet: ProbeSet 1630429_s_at aligns to a genomic region shared by exons of 2 FlyBase-annotated genes; hence it is impossible to interpret the expression pattern and levels of CG11889 expression signal. See the GBrowse view of CG11889 to determine the overlapping gene(s). Gene sequence location is 3R:21095953..21098989.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 96C8-96C8   Limits computationally determined from genome sequence between P{PZ}Aats-gln05461 and P{EP}EP3354
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG11891 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	gene_with_dicistronic_mRNA ; SO:0000722 Gene model reviewed during 5.47 Mutation in sequenced strain: complex.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG11891-RD FBtr0300131  NM_143111   2922   420 CG11891-RE FBtr0300132  NM_001032040   1337   420
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG11891-PD   FBpp0289408   48.8   420   7.34     NP_651368   AAO41603 CG11891-PE   FBpp0289409   48.8   420   7.34     NP_001027211   AAZ52546
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • CHK kinase-like (IPR015897) Protein of unknown function DUF227 (IPR004119) Protein kinase-like domain (IPR011009)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAO41603   AE014297 AAZ52546   AY089256 AAL89994   AY094664 AAM11017   BF490779   BF495508   BT082006   CO263454   CO341755   EC231321   EC238752   ES696215   EV598352
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8T4C5 Q8T3P4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult midgut, larval/adult Malpighian tubules. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult central nervous system, adult hindgut. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    2.7 Larval Midgut    4.9 Larval Hindgut    15.9 Larval Malpighian Tubules    699.1 Larval Fat Body    3.3 Larval Salivary Gland    3.7 Larval Trachea    3.8 Larval Carcass    1.625 Adult Head    163.8 Adult Eye    13.875 Adult Brain    154.3 Adult Thoracic-Abdominal Ganglion    183.7 Adult Crop    1.8 Adult Midgut    759.7 Adult Hindgut    213.1 Adult Malpighian Tubules    1352.4 Adult Fat Body    8.7 Adult Salivary Gland    11.7 Adult Heart    3.15 Adult VirginFemale Spermatheca    12 Adult InseminatedFemale Spermatheca    5 Adult Ovary    1.3 Adult Testis    37.5 Adult Male Accessory Gland    3.9 Adult Carcass    77.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    2.7 Larval Midgut    4.9 Larval Hindgut    15.9 Larval Malpighian Tubules  (699.1) Larval Fat Body    3.3 Larval Salivary Gland    3.7 Larval Trachea    3.8 Larval Carcass    1.625 Adult Head    163.8 Adult Eye    13.875 Adult Brain    154.3 Adult Thoracic-Abdominal Ganglion    183.7 Adult Crop    1.8 Adult Midgut  (759.7) Adult Hindgut    213.1 Adult Malpighian Tubules  (1352.4) Adult Fat Body    8.7 Adult Salivary Gland    11.7 Adult Heart    3.15 Adult VirginFemale Spermatheca    12 Adult InseminatedFemale Spermatheca    5 Adult Ovary    1.3 Adult Testis    37.5 Adult Male Accessory Gland    3.9 Adult Carcass    77.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    2.7 Larval Midgut    4.9 Larval Hindgut    15.9 Larval Malpighian Tubules    699.1 Larval Fat Body    3.3 Larval Salivary Gland    3.7 Larval Trachea    3.8 Larval Carcass    1.625 Adult Head    163.8 Adult Eye    13.875 Adult Brain    154.3 Adult Thoracic-Abdominal Ganglion    183.7 Adult Crop    1.8 Adult Midgut    759.7 Adult Hindgut    213.1 Adult Malpighian Tubules  (1352.4) Adult Fat Body    8.7 Adult Salivary Gland    11.7 Adult Heart    3.15 Adult VirginFemale Spermatheca    12 Adult InseminatedFemale Spermatheca    5 Adult Ovary    1.3 Adult Testis    37.5 Adult Male Accessory Gland    3.9 Adult Carcass    77.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2.7 Larval Midgut    4.9 Larval Hindgut    15.9 Larval Malpighian Tubules    699.1 Larval Fat Body    3.3 Larval Salivary Gland    3.7 Larval Trachea    3.8 Larval Carcass    1.625 Adult Head    163.8 Adult Eye    13.875 Adult Brain    154.3 Adult Thoracic-Abdominal Ganglion    183.7 Adult Crop    1.8 Adult Midgut    759.7 Adult Hindgut    213.1 Adult Malpighian Tubules    1352.4 Adult Fat Body    8.7 Adult Salivary Gland    11.7 Adult Heart    3.15 Adult VirginFemale Spermatheca    12 Adult InseminatedFemale Spermatheca    5 Adult Ovary    1.3 Adult Testis    37.5 Adult Male Accessory Gland    3.9 Adult Carcass    77.4 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    2.7 Larval Midgut    4.9 Larval Hindgut    15.9 Larval Malpighian Tubules    699.1 Larval Fat Body    3.3 Larval Salivary Gland    3.7 Larval Trachea    3.8 Larval Carcass    1.625 Adult Head    163.8 Adult Eye    13.875 Adult Brain    154.3 Adult Thoracic-Abdominal Ganglion    183.7 Adult Crop    1.8 Adult Midgut    759.7 Adult Hindgut    213.1 Adult Malpighian Tubules    1352.4 Adult Fat Body    8.7 Adult Salivary Gland    11.7 Adult Heart    3.15 Adult VirginFemale Spermatheca    12 Adult InseminatedFemale Spermatheca    5 Adult Ovary    1.3 Adult Testis    37.5 Adult Male Accessory Gland    3.9 Adult Carcass    77.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    2.7 Larval Midgut    4.9 Larval Hindgut    15.9 Larval Malpighian Tubules  699.1 Larval Fat Body    3.3 Larval Salivary Gland    3.7 Larval Trachea    3.8 Larval Carcass    1.625 Adult Head    163.8 Adult Eye    13.875 Adult Brain    154.3 Adult Thoracic-Abdominal Ganglion    183.7 Adult Crop    1.8 Adult Midgut  759.7 Adult Hindgut    213.1 Adult Malpighian Tubules  (1352.4) Adult Fat Body    8.7 Adult Salivary Gland    11.7 Adult Heart    3.15 Adult VirginFemale Spermatheca    12 Adult InseminatedFemale Spermatheca    5 Adult Ovary    1.3 Adult Testis    37.5 Adult Male Accessory Gland    3.9 Adult Carcass    77.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    2.7 Larval Midgut    4.9 Larval Hindgut    15.9 Larval Malpighian Tubules    699.1 Larval Fat Body    3.3 Larval Salivary Gland    3.7 Larval Trachea    3.8 Larval Carcass    1.625 Adult Head    163.8 Adult Eye    13.875 Adult Brain    154.3 Adult Thoracic-Abdominal Ganglion    183.7 Adult Crop    1.8 Adult Midgut    759.7 Adult Hindgut    213.1 Adult Malpighian Tubules  1352.4 Adult Fat Body    8.7 Adult Salivary Gland    11.7 Adult Heart    3.15 Adult VirginFemale Spermatheca    12 Adult InseminatedFemale Spermatheca    5 Adult Ovary    1.3 Adult Testis    37.5 Adult Male Accessory Gland    3.9 Adult Carcass    77.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2.7 Larval Midgut    4.9 Larval Hindgut    15.9 Larval Malpighian Tubules    699.1 Larval Fat Body    3.3 Larval Salivary Gland    3.7 Larval Trachea    3.8 Larval Carcass    1.625 Adult Head    163.8 Adult Eye    13.875 Adult Brain    154.3 Adult Thoracic-Abdominal Ganglion    183.7 Adult Crop    1.8 Adult Midgut    759.7 Adult Hindgut    213.1 Adult Malpighian Tubules    1352.4 Adult Fat Body    8.7 Adult Salivary Gland    11.7 Adult Heart    3.15 Adult VirginFemale Spermatheca    12 Adult InseminatedFemale Spermatheca    5 Adult Ovary    1.3 Adult Testis    37.5 Adult Male Accessory Gland    3.9 Adult Carcass    77.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    163.8   NA  Eye    no informative data   NA  Brain    154.3   2.7  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    183.7   NA  Crop    1.8   4.9  Midgut    759.7   15.9  Hindgut    213.1   699.1  Malpighian Tubules    1352.4   3.3  Fat Body    8.7   3.7  Salivary Gland    no informative data   NA  Heart    3.15   3.8  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    5   NA  Ovary    1.3   NA  Testis    37.5   NA  Male Accessory Gland    3.9   1.625  Carcass    77.4 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    0 central nervous system, pupae P8    3 head, virgin 1-day female    32 head, virgin 4-day female    13 head, virgin 20-day female    14 head, mated 1-day female    12 head, mated 4-day female    14 head, mated 20-day female    12 head, mated 1-day male    19 head, mated 4-day male    14 head, mated 20-day male    21 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    23 digestive system, 1-day adult    57 digestive system, 4-day adult    39 digestive system, 20-day adult    36 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    1 carcass, larvae L3 wandering    0 carcass, 1-day adult    15 carcass, 4-day adult    12 carcass, 20-day adult    8 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    20 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    0 central nervous system, pupae P8    3 head, virgin 1-day female  (32) head, virgin 4-day female    13 head, virgin 20-day female    14 head, mated 1-day female    12 head, mated 4-day female    14 head, mated 20-day female    12 head, mated 1-day male    19 head, mated 4-day male    14 head, mated 20-day male    21 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    23 digestive system, 1-day adult  (57) digestive system, 4-day adult  (39) digestive system, 20-day adult  (36) fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    1 carcass, larvae L3 wandering    0 carcass, 1-day adult    15 carcass, 4-day adult    12 carcass, 20-day adult    8 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    20 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    0 central nervous system, pupae P8    3 head, virgin 1-day female    32 head, virgin 4-day female    13 head, virgin 20-day female    14 head, mated 1-day female    12 head, mated 4-day female    14 head, mated 20-day female    12 head, mated 1-day male    19 head, mated 4-day male    14 head, mated 20-day male    21 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    23 digestive system, 1-day adult    57 digestive system, 4-day adult    39 digestive system, 20-day adult    36 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    1 carcass, larvae L3 wandering    0 carcass, 1-day adult    15 carcass, 4-day adult    12 carcass, 20-day adult    8 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    20 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    0 central nervous system, pupae P8    3 head, virgin 1-day female    32 head, virgin 4-day female    13 head, virgin 20-day female    14 head, mated 1-day female    12 head, mated 4-day female    14 head, mated 20-day female    12 head, mated 1-day male    19 head, mated 4-day male    14 head, mated 20-day male    21 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    23 digestive system, 1-day adult    57 digestive system, 4-day adult    39 digestive system, 20-day adult    36 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    1 carcass, larvae L3 wandering    0 carcass, 1-day adult    15 carcass, 4-day adult    12 carcass, 20-day adult    8 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    20 accessory gland, mated 4-day male    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    0 central nervous system, pupae P8    3 head, virgin 1-day female    32 head, virgin 4-day female    13 head, virgin 20-day female    14 head, mated 1-day female    12 head, mated 4-day female    14 head, mated 20-day female    12 head, mated 1-day male    19 head, mated 4-day male    14 head, mated 20-day male    21 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    23 digestive system, 1-day adult    57 digestive system, 4-day adult    39 digestive system, 20-day adult    36 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    1 carcass, larvae L3 wandering    0 carcass, 1-day adult    15 carcass, 4-day adult    12 carcass, 20-day adult    8 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    20 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    0 central nervous system, pupae P8    3 head, virgin 1-day female  32 head, virgin 4-day female    13 head, virgin 20-day female    14 head, mated 1-day female    12 head, mated 4-day female    14 head, mated 20-day female    12 head, mated 1-day male    19 head, mated 4-day male    14 head, mated 20-day male    21 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    23 digestive system, 1-day adult  (57) digestive system, 4-day adult  (39) digestive system, 20-day adult  (36) fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    1 carcass, larvae L3 wandering    0 carcass, 1-day adult    15 carcass, 4-day adult    12 carcass, 20-day adult    8 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    20 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    0 central nervous system, pupae P8    3 head, virgin 1-day female    32 head, virgin 4-day female    13 head, virgin 20-day female    14 head, mated 1-day female    12 head, mated 4-day female    14 head, mated 20-day female    12 head, mated 1-day male    19 head, mated 4-day male    14 head, mated 20-day male    21 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    23 digestive system, 1-day adult    57 digestive system, 4-day adult    39 digestive system, 20-day adult    36 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    1 carcass, larvae L3 wandering    0 carcass, 1-day adult    15 carcass, 4-day adult    12 carcass, 20-day adult    8 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    20 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    0 central nervous system, pupae P8    3 head, virgin 1-day female    32 head, virgin 4-day female    13 head, virgin 20-day female    14 head, mated 1-day female    12 head, mated 4-day female    14 head, mated 20-day female    12 head, mated 1-day male    19 head, mated 4-day male    14 head, mated 20-day male    21 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    23 digestive system, 1-day adult    57 digestive system, 4-day adult    39 digestive system, 20-day adult    36 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    1 carcass, larvae L3 wandering    0 carcass, 1-day adult    15 carcass, 4-day adult    12 carcass, 20-day adult    8 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    20 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed within 18-24 hour embryonic stages, at stages throughout the larval period, in adult male stages. This gene is annotated by FlyBase as a dicistronic gene, meaning that some or all of its transcripts encode two or more polypeptide-coding open reading frames (ORFs) , with each ORF assigned to a different gene. The distribution of RNA-Seq coverage data amongst the different encoded genes cannot be determined. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    1 embryo 18-20hr    5 embryo 20-22hr    17 embryo 22-24hr    22 larva L1    14 larva L2    22 larva L3 12hr old    27 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    3 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    14 adult male 01day    21 adult male 05day    18 adult male 30day    17 adult female 01day    8 adult female 05day    4 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    1 embryo 18-20hr    5 embryo 20-22hr    17 embryo 22-24hr    22 larva L1    14 larva L2    22 larva L3 12hr old  (27) larva L3 puffstage 1-2    21 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    3 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    14 adult male 01day    21 adult male 05day    18 adult male 30day    17 adult female 01day    8 adult female 05day    4 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    1 embryo 18-20hr    5 embryo 20-22hr    17 embryo 22-24hr    22 larva L1    14 larva L2    22 larva L3 12hr old    27 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    3 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    14 adult male 01day    21 adult male 05day    18 adult male 30day    17 adult female 01day    8 adult female 05day    4 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    1 embryo 18-20hr    5 embryo 20-22hr    17 embryo 22-24hr    22 larva L1    14 larva L2    22 larva L3 12hr old    27 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    3 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    14 adult male 01day    21 adult male 05day    18 adult male 30day    17 adult female 01day    8 adult female 05day    4 adult female 30day    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    1 embryo 18-20hr    5 embryo 20-22hr    17 embryo 22-24hr    22 larva L1    14 larva L2    22 larva L3 12hr old    27 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    3 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    14 adult male 01day    21 adult male 05day    18 adult male 30day    17 adult female 01day    8 adult female 05day    4 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    1 embryo 18-20hr    5 embryo 20-22hr    17 embryo 22-24hr    22 larva L1    14 larva L2    22 larva L3 12hr old  27 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    3 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    14 adult male 01day    21 adult male 05day    18 adult male 30day    17 adult female 01day    8 adult female 05day    4 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    1 embryo 18-20hr    5 embryo 20-22hr    17 embryo 22-24hr    22 larva L1    14 larva L2    22 larva L3 12hr old    27 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    3 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    14 adult male 01day    21 adult male 05day    18 adult male 30day    17 adult female 01day    8 adult female 05day    4 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    1 embryo 18-20hr    5 embryo 20-22hr    17 embryo 22-24hr    22 larva L1    14 larva L2    22 larva L3 12hr old    27 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    3 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    14 adult male 01day    21 adult male 05day    18 adult male 30day    17 adult female 01day    8 adult female 05day    4 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    6 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    6 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    6 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    6 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    6 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    6 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    6 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    6 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    39 Cadmium 50 mM 6 hrs, larvae L3    20 Cadmium 50 mM 12 hrs, larvae L3    21 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    28 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    51 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    19 Caffeine 1.5 mg/ml 4 hrs, larvae L3    21 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    15 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult  (39) Cadmium 50 mM 6 hrs, larvae L3    20 Cadmium 50 mM 12 hrs, larvae L3    21 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult  (28) Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3  (51) Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    19 Caffeine 1.5 mg/ml 4 hrs, larvae L3    21 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    15 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    39 Cadmium 50 mM 6 hrs, larvae L3    20 Cadmium 50 mM 12 hrs, larvae L3    21 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    28 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    51 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    19 Caffeine 1.5 mg/ml 4 hrs, larvae L3    21 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    15 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    39 Cadmium 50 mM 6 hrs, larvae L3    20 Cadmium 50 mM 12 hrs, larvae L3    21 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    28 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    51 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    19 Caffeine 1.5 mg/ml 4 hrs, larvae L3    21 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    15 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    39 Cadmium 50 mM 6 hrs, larvae L3    20 Cadmium 50 mM 12 hrs, larvae L3    21 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    28 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    51 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    19 Caffeine 1.5 mg/ml 4 hrs, larvae L3    21 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    15 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult  (39) Cadmium 50 mM 6 hrs, larvae L3    20 Cadmium 50 mM 12 hrs, larvae L3    21 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult  28 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3  (51) Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    19 Caffeine 1.5 mg/ml 4 hrs, larvae L3    21 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    15 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    39 Cadmium 50 mM 6 hrs, larvae L3    20 Cadmium 50 mM 12 hrs, larvae L3    21 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    28 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    51 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    19 Caffeine 1.5 mg/ml 4 hrs, larvae L3    21 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    15 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    39 Cadmium 50 mM 6 hrs, larvae L3    20 Cadmium 50 mM 12 hrs, larvae L3    21 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    28 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    51 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    19 Caffeine 1.5 mg/ml 4 hrs, larvae L3    21 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    15 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
External Data & Images
Linkouts	BDGP expression data • AT04450 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039309
Alleles & Phenotypes
Summary of Allele Phenotypes
Phenotype manifest in Allele
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of CG11891 Class Mutagen Stocks Known lesion CG11891MB05006 1 -- CG11891MB06268 1 -- CG11891MI06010 1 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG11891 Class Mutagen Stocks Known lesion CG11891JF02046 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG11891NIG.11891R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)FDD-0247625 (DrosDel Project, 2008.11.14)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{NIG.11891R} NA P{TRiP.JF02046} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system Mi{ET1}CG11889MB05006 No Mi{ET1}CG11889MB06268 No miscellaneous insertions Mi{MIC}CG11889MI06010 NA
Gene Ontology: Function, Process & Cellular Component ( 1 unique term )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function
CV term Evidence References
transferase activity, transferring phosphorus-containing groups inferred from electronic annotation with InterPro:IPR011009 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	gene_with_dicistronic_mRNA (FlyBase Genome Annotators, 2002-2003) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG11891 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0039309
Orthologs
OrthoDB Orthologs (67) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG63JCQR Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search EOG6S7HKM Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search EOG6T1WF6
Orthologs in Drosophila Species (EOG63JCQR)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG11889     Drosophila melanogaster fruit fly  Dmel\CG11878     Drosophila melanogaster fruit fly  Dmel\CG11891     Drosophila simulans   Dsim\GD21199   Y Drosophila simulans   Dsim\GD21200   Y Drosophila simulans   Dsim\GD21201   Y Drosophila simulans   Dsim\GD21197   Y Drosophila simulans   Dsim\GD21198   Y Drosophila sechellia   Dsec\GM17830   Y Drosophila sechellia   Dsec\GM17833   Y Drosophila sechellia   Dsec\GM17829   Y Drosophila erecta   Dere\GG11389 Y Y Drosophila erecta   Dere\GG11387   Y Drosophila erecta   Dere\GG11390   Y Drosophila erecta   Dere\GG11386   Y Drosophila yakuba   Dyak\GE23583   Y Drosophila yakuba   Dyak\GE23587 Y Y Drosophila yakuba   Dyak\GE23586   Y Drosophila yakuba   Dyak\GE23588   Y Drosophila yakuba   Dyak\GE23584   Y Drosophila ananassae   Dana\GF17560   Y Drosophila ananassae   Dana\GF17561   Y Drosophila ananassae   Dana\GF17562   Y Drosophila pseudoobscura pseudoobscura   Dpse\GA11254   Y Drosophila persimilis   Dper\GL21713   Y Drosophila willistoni   Dwil\GK12927   Y Drosophila virilis   Dvir\GJ23245   Y Drosophila mojavensis   Dmoj\GI23685   Y Drosophila grimshawi   Dgri\GH14824   Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (EOG6S7HKM)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC724781 Y Apis mellifera Western honey bee  Amel\LOC408421 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG016853 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH10151 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH10147 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH10152 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH10150 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH10149 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH13386 Y Atta cephalotes Leafcutter ant  Acep\ACEP20691 Y Atta cephalotes Leafcutter ant  Acep\ACEP20710 Y Atta cephalotes Leafcutter ant  Acep\ACEP20697 Y Atta cephalotes Leafcutter ant  Acep\ACEP20693 Y Atta cephalotes Leafcutter ant  Acep\ACEP24818 Y Atta cephalotes Leafcutter ant  Acep\ACEP20696 Y Atta cephalotes Leafcutter ant  Acep\ACEP20689 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO16473 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO18285 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO13657 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO14766 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO21763 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL17596 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL15853 Y Linepithema humile Argentine ant  Lhum\LH21708 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB10728 Y Solenopsis invicta Red fire ant  Sinv\SINV18236 Y Solenopsis invicta Red fire ant  Sinv\SINV19073 Y Solenopsis invicta Red fire ant  Sinv\SINV24893 Y Pediculus humanus Human body louse  Phum\PHUM572000 Y Pediculus humanus Human body louse  Phum\PHUM572010 Y Pediculus humanus Human body louse  Phum\PHUM572020 Y Pediculus humanus Human body louse  Phum\PHUM571990 Y Tribolium castaneum Red flour beetle  Tcas\TC015939 Y
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (EOG6T1WF6)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\T16G1.3 Y Caenorhabditis elegans Nematode  Cele\E02C12.12 Y Caenorhabditis elegans Nematode  Cele\Y11D7A.8 Y Caenorhabditis elegans Nematode  Cele\F20D6.5 Y Caenorhabditis elegans Nematode  Cele\C29F7.1 Y
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (2) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila erecta Dere\GG11389 Drosophila yakuba Dyak\GE23587
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	26021 y1 v1; P{TRiP.JF02046}attP2 24845 w1118; Mi{ET1}CG11889MB05006 CG11891MB05006 26044 w1118; Mi{ET1}CG11889MB06268 CG11891MB06268 42130 y1 w*; Mi{MIC}CG11889MI06010 CG11891MI06010
Genomic Clones ( 3 )
	BACR06L08 BACR10P10 BACR17E12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 8 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT04450 AT27361
Other clones	MIP04440
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	165782 CK01.106A.F8 Dmel_neb_008388_0952_0601 EK088556 EP13106
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0039309 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 3772439
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments	Dicistronic annotation CG33091 split out into separate annotations for each open reading frame, CG11889 and CG11891, in release 4.2 of the genome annotation. (FlyBase Genome Annotators, 2005) One or more of the processed transcripts for this gene contain(s) two non-overlapping open reading frames (ORFs). The non-overlapping ORFs are represented by CG11889 and CG11891. (FlyBase Genome Annotators, 2002-2003)
Other Comments
	Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days. Shows significant change of expression pattern in circadian mutant background; increased expression in per01, tim01 and ClkJrk background. (Claridge-Chang et al., 2001)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_143111 NM_001032040 RefSeq (Proteins) • NP_651368 NP_001027211 DDBJ / EMBL / GenBank • AAF56437.2 AAF56438.1 AAL89994 AAM11017 AAO41603 AAO41603.1 AAZ52546 AY089256 AY094664 BF490779 BF495508 Entrez Gene - A searchable database of RefSeq genes. • 3772439 UniProtKB/TrEMBL • Q8T3P4 Q8T4C5
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • CHK kinase-like (IPR015897) Protein of unknown function DUF227 (IPR004119) Protein kinase-like domain (IPR011009) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • AT04450
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0039309 DRSC - Results from RNAi screens. • FBgn0039309 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039309 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0039309 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 3772439 modMine - Data generated by the modENCODE project. • FBgn0039309
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	CG11891 (Perkins et al., 1.15.2009, Japanese National Institute of Genetics, 2012.5.21) CG33091 (Giot et al., 2003, Riedl et al., 2005) CT37044 (Ceriani et al., 2002)
Name Synonym
Secondary FlyBase IDs
	FBgn0053091 FBpp0084193 FBpp0084194 FBpp0084195 FBtr0084818 FBtr0084819 FBtr0084820
References ( 17 )
Research paper	Riedl et al., 2005, Behav. Genet. 35(3): 231--244 Drosophila soluble guanylyl cyclase mutants exhibit increased foraging locomotion: behavioral and genomic investigations. [FBrf0187131] Ceriani et al., 2002, J. Neurosci. 22(21): 9305--9319 Genome-wide expression analysis in Drosophila reveals genes controlling circadian behavior. [FBrf0152147] Lin et al., 2002, Proc. Natl. Acad. Sci. U.S.A. 99(14): 9562--9567 Influence of the period-dependent circadian clock on diurnal, circadian, and aperiodic gene expression in Drosophila melanogaster. [FBrf0151475] Ueda et al., 2002, J. Biol. Chem. 277(16): 14048--14052 Genome-wide transcriptional orchestration of circadian rhythms in Drosophila. [FBrf0149598] Claridge-Chang et al., 2001, Neuron 32(4): 657--671 Circadian regulation of gene expression systems in the Drosophila head. [FBrf0141689]
Supplementary material	Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Review	Etter and Ramaswami, 2002, BioEssays 24(6): 494--498 The ups and downs of daily life: profiling circadian gene expression in Drosophila. [FBrf0148902]
Personal communication to FlyBase	Bellen, 2012.10.23, set1006_v2.xml set1006_v2.xml [FBrf0219849] Perkins et al., 1.15.2009, Initial TRiP stock collection. Initial TRiP stock collection. [FBrf0206489] Bellen, 2008.11.7, set816.xml set816.xml [FBrf0206132] Bellen, 2008.1.15, batch770_take2.xml batch770_take2.xml [FBrf0202437] DrosDel Project, 2008.11.14, Deletion FDD-0247625. Deletion FDD-0247625. [FBrf0206146] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]
FlyBase analysis	FlyBase Genome Annotators, 2005, Changes affecting gene model number or type in release 4.2 of the annotated D.melanogaster genome. Changes affecting gene model number or type in release 4.2 of the annotated D.melanogaster genome. [FBrf0182792] FlyBase Genome Annotators, 2002-2003, Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome. Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome. [FBrf0148886]
Stock list	Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY. RNAi stocks available from NIG-FLY. [FBrf0218457]