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Gene Dmel\CG10550

General Information
Symbol	Dmel\CG10550	Species	D. melanogaster
Name		Annotation symbol	CG10550
Feature type	protein_coding_gene	FlyBase ID	FBgn0039321
Gene Model Status	Current	Stock availability	2 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	96D1-96D1	Sequence location	3R:21,132,129..21,134,113 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG10550 (FBgn0039321). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: transferase activity, transferring phosphorus-containing groups. The biological processes in which it is involved are not known. 2 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: CHK kinase-like; Protein kinase-like domain; Protein of unknown function DUF227. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 18-24 hour embryonic stages, during late pupal stages, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, adult hindgut, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval hindgut, adult heart, adult fat body, adult salivary gland, larval trachea, adult spermathecae, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1639660_s_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of CG10550. Gene sequence location is 3R:21132129..21134113.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 96D1-96D1   Limits computationally determined from genome sequence between P{PZ}Aats-gln05461 and P{EP}EP3354
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG10550 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47 DGC clone GH16930 appears problematic: unspliced intron
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG10550-RB FBtr0084857  NM_170218   1464   425 CG10550-RC FBtr0084858  NM_170219   1594   425 CG10550-RD FBtr0305953  NM_143123   1460   425
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG10550-PB   FBpp0084231   49.1   425   4.85     NP_733097   AAF56451 CG10550-PC   FBpp0084232   49.1   425   4.85     NP_733098   AAN14048 CG10550-PD   FBpp0297095   49.1   425   4.85     NP_651380   AAF56450
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • CHK kinase-like (IPR015897) Protein of unknown function DUF227 (IPR004119) Protein kinase-like domain (IPR011009)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF56450   AE014297 AAF56451   AE014297 AAN14048   AI107167   AI108416   AI109926   AI114079   AI386741   AI387562   AI388861   AI403644   AI403718   AI404019   AW940641   AY051516 AAK92940   BF489086   BG632316   BI163549   BI238994   BI357142   BI357164   BI368157   BI604526   BI612698   BI638267   BI638320   BI640993   BT099544   BT133478   CO275278   CO281122   CO339198   EC061680   EC071427   EC208869   EC245048   EC260005   FD586440   FD586829   FD587085   FD587312   FD587513   GH738924   GH740120   GH743791   GH744058   GH762388   GH766456   GH767611   GH769763   GH779178   GH779311
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VBS7 Q961M0
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, adult hindgut, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval hindgut, adult heart, adult fat body, adult salivary gland, larval trachea, adult spermathecae, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    146.25 Larval Midgut    746.9 Larval Hindgut    427.5 Larval Malpighian Tubules    28 Larval Fat Body    13 Larval Salivary Gland    88.1 Larval Trachea    326.6 Larval Carcass    158.9 Adult Head    1423 Adult Eye    1136.475 Adult Brain    702.8 Adult Thoracic-Abdominal Ganglion    1013 Adult Crop    2649.2 Adult Midgut    954.7 Adult Hindgut    1442 Adult Malpighian Tubules    56.9 Adult Fat Body    106.8 Adult Salivary Gland    206.5 Adult Heart    319.375 Adult VirginFemale Spermatheca    134.1 Adult InseminatedFemale Spermatheca    172.9 Adult Ovary    4.4 Adult Testis    9.2 Adult Male Accessory Gland    36.9 Adult Carcass    961.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    146.25 Larval Midgut  (746.9) Larval Hindgut    427.5 Larval Malpighian Tubules    28 Larval Fat Body    13 Larval Salivary Gland    88.1 Larval Trachea    326.6 Larval Carcass    158.9 Adult Head  (1423) Adult Eye  (1136.475) Adult Brain  (702.8) Adult Thoracic-Abdominal Ganglion  (1013) Adult Crop  (2649.2) Adult Midgut  (954.7) Adult Hindgut  (1442) Adult Malpighian Tubules    56.9 Adult Fat Body    106.8 Adult Salivary Gland    206.5 Adult Heart    319.375 Adult VirginFemale Spermatheca    134.1 Adult InseminatedFemale Spermatheca    172.9 Adult Ovary    4.4 Adult Testis    9.2 Adult Male Accessory Gland    36.9 Adult Carcass  (961.3) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    146.25 Larval Midgut    746.9 Larval Hindgut    427.5 Larval Malpighian Tubules    28 Larval Fat Body    13 Larval Salivary Gland    88.1 Larval Trachea    326.6 Larval Carcass    158.9 Adult Head  (1423) Adult Eye  (1136.475) Adult Brain    702.8 Adult Thoracic-Abdominal Ganglion  1013 Adult Crop  (2649.2) Adult Midgut    954.7 Adult Hindgut  (1442) Adult Malpighian Tubules    56.9 Adult Fat Body    106.8 Adult Salivary Gland    206.5 Adult Heart    319.375 Adult VirginFemale Spermatheca    134.1 Adult InseminatedFemale Spermatheca    172.9 Adult Ovary    4.4 Adult Testis    9.2 Adult Male Accessory Gland    36.9 Adult Carcass    961.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    146.25 Larval Midgut    746.9 Larval Hindgut    427.5 Larval Malpighian Tubules    28 Larval Fat Body    13 Larval Salivary Gland    88.1 Larval Trachea    326.6 Larval Carcass    158.9 Adult Head    1423 Adult Eye    1136.475 Adult Brain    702.8 Adult Thoracic-Abdominal Ganglion    1013 Adult Crop    2649.2 Adult Midgut    954.7 Adult Hindgut    1442 Adult Malpighian Tubules    56.9 Adult Fat Body    106.8 Adult Salivary Gland    206.5 Adult Heart    319.375 Adult VirginFemale Spermatheca    134.1 Adult InseminatedFemale Spermatheca    172.9 Adult Ovary    4.4 Adult Testis    9.2 Adult Male Accessory Gland    36.9 Adult Carcass    961.3 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    146.25 Larval Midgut    746.9 Larval Hindgut    427.5 Larval Malpighian Tubules    28 Larval Fat Body    13 Larval Salivary Gland    88.1 Larval Trachea    326.6 Larval Carcass    158.9 Adult Head    1423 Adult Eye    1136.475 Adult Brain    702.8 Adult Thoracic-Abdominal Ganglion    1013 Adult Crop    2649.2 Adult Midgut    954.7 Adult Hindgut    1442 Adult Malpighian Tubules    56.9 Adult Fat Body    106.8 Adult Salivary Gland    206.5 Adult Heart    319.375 Adult VirginFemale Spermatheca    134.1 Adult InseminatedFemale Spermatheca    172.9 Adult Ovary    4.4 Adult Testis    9.2 Adult Male Accessory Gland    36.9 Adult Carcass    961.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    146.25 Larval Midgut  746.9 Larval Hindgut    427.5 Larval Malpighian Tubules    28 Larval Fat Body    13 Larval Salivary Gland    88.1 Larval Trachea    326.6 Larval Carcass    158.9 Adult Head  (1423) Adult Eye  (1136.475) Adult Brain  702.8 Adult Thoracic-Abdominal Ganglion  (1013) Adult Crop  (2649.2) Adult Midgut  (954.7) Adult Hindgut  (1442) Adult Malpighian Tubules    56.9 Adult Fat Body    106.8 Adult Salivary Gland    206.5 Adult Heart    319.375 Adult VirginFemale Spermatheca    134.1 Adult InseminatedFemale Spermatheca    172.9 Adult Ovary    4.4 Adult Testis    9.2 Adult Male Accessory Gland    36.9 Adult Carcass  (961.3) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    146.25 Larval Midgut    746.9 Larval Hindgut    427.5 Larval Malpighian Tubules    28 Larval Fat Body    13 Larval Salivary Gland    88.1 Larval Trachea    326.6 Larval Carcass    158.9 Adult Head  1423 Adult Eye  1136.475 Adult Brain    702.8 Adult Thoracic-Abdominal Ganglion  1013 Adult Crop  (2649.2) Adult Midgut    954.7 Adult Hindgut  1442 Adult Malpighian Tubules    56.9 Adult Fat Body    106.8 Adult Salivary Gland    206.5 Adult Heart    319.375 Adult VirginFemale Spermatheca    134.1 Adult InseminatedFemale Spermatheca    172.9 Adult Ovary    4.4 Adult Testis    9.2 Adult Male Accessory Gland    36.9 Adult Carcass    961.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    146.25 Larval Midgut    746.9 Larval Hindgut    427.5 Larval Malpighian Tubules    28 Larval Fat Body    13 Larval Salivary Gland    88.1 Larval Trachea    326.6 Larval Carcass    158.9 Adult Head    1423 Adult Eye    1136.475 Adult Brain    702.8 Adult Thoracic-Abdominal Ganglion    1013 Adult Crop    2649.2 Adult Midgut    954.7 Adult Hindgut    1442 Adult Malpighian Tubules    56.9 Adult Fat Body    106.8 Adult Salivary Gland    206.5 Adult Heart    319.375 Adult VirginFemale Spermatheca    134.1 Adult InseminatedFemale Spermatheca    172.9 Adult Ovary    4.4 Adult Testis    9.2 Adult Male Accessory Gland    36.9 Adult Carcass    961.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    1423   NA  Eye    1136.475   NA  Brain    702.8   146.25  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1013   NA  Crop    2649.2   746.9  Midgut    954.7   427.5  Hindgut    1442   28  Malpighian Tubules    56.9   no informative data  Fat Body    106.8   88.1  Salivary Gland    206.5   NA  Heart    319.375   326.6  Trachea    NA   NA  VirginFemale Spermatheca    134.1   NA  InseminatedFemale Spermatheca    172.9   NA  Ovary    4.4   NA  Testis    9.2   NA  Male Accessory Gland    36.9   158.9  Carcass    961.3 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    2 central nervous system, pupae P8    5 head, virgin 1-day female    136 head, virgin 4-day female    107 head, virgin 20-day female    109 head, mated 1-day female    131 head, mated 4-day female    129 head, mated 20-day female    92 head, mated 1-day male    175 head, mated 4-day male    171 head, mated 20-day male    183 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    58 digestive system, 1-day adult    72 digestive system, 4-day adult    63 digestive system, 20-day adult    35 fat body, larvae L3 wandering    2 fat body, white prepupae    0 fat body, pupae P8    1 carcass, larvae L3 wandering    6 carcass, 1-day adult    86 carcass, 4-day adult    75 carcass, 20-day adult    61 ovary, virgin 4-day female    1 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    2 central nervous system, pupae P8    5 head, virgin 1-day female  (136) head, virgin 4-day female  (107) head, virgin 20-day female  (109) head, mated 1-day female  (131) head, mated 4-day female  (129) head, mated 20-day female  (92) head, mated 1-day male  (175) head, mated 4-day male  (171) head, mated 20-day male  (183) salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    0 digestive system, larvae L3 wandering  (58) digestive system, 1-day adult  (72) digestive system, 4-day adult  (63) digestive system, 20-day adult  (35) fat body, larvae L3 wandering    2 fat body, white prepupae    0 fat body, pupae P8    1 carcass, larvae L3 wandering    6 carcass, 1-day adult  (86) carcass, 4-day adult  (75) carcass, 20-day adult  (61) ovary, virgin 4-day female    1 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    2 central nervous system, pupae P8    5 head, virgin 1-day female  (136) head, virgin 4-day female  107 head, virgin 20-day female  (109) head, mated 1-day female  (131) head, mated 4-day female  (129) head, mated 20-day female    92 head, mated 1-day male  (175) head, mated 4-day male  (171) head, mated 20-day male  (183) salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    58 digestive system, 1-day adult    72 digestive system, 4-day adult    63 digestive system, 20-day adult    35 fat body, larvae L3 wandering    2 fat body, white prepupae    0 fat body, pupae P8    1 carcass, larvae L3 wandering    6 carcass, 1-day adult    86 carcass, 4-day adult    75 carcass, 20-day adult    61 ovary, virgin 4-day female    1 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    2 central nervous system, pupae P8    5 head, virgin 1-day female    136 head, virgin 4-day female    107 head, virgin 20-day female    109 head, mated 1-day female    131 head, mated 4-day female    129 head, mated 20-day female    92 head, mated 1-day male    175 head, mated 4-day male    171 head, mated 20-day male    183 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    58 digestive system, 1-day adult    72 digestive system, 4-day adult    63 digestive system, 20-day adult    35 fat body, larvae L3 wandering    2 fat body, white prepupae    0 fat body, pupae P8    1 carcass, larvae L3 wandering    6 carcass, 1-day adult    86 carcass, 4-day adult    75 carcass, 20-day adult    61 ovary, virgin 4-day female    1 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    2 central nervous system, pupae P8    5 head, virgin 1-day female    136 head, virgin 4-day female    107 head, virgin 20-day female    109 head, mated 1-day female    131 head, mated 4-day female    129 head, mated 20-day female    92 head, mated 1-day male    175 head, mated 4-day male    171 head, mated 20-day male    183 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    58 digestive system, 1-day adult    72 digestive system, 4-day adult    63 digestive system, 20-day adult    35 fat body, larvae L3 wandering    2 fat body, white prepupae    0 fat body, pupae P8    1 carcass, larvae L3 wandering    6 carcass, 1-day adult    86 carcass, 4-day adult    75 carcass, 20-day adult    61 ovary, virgin 4-day female    1 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    2 central nervous system, pupae P8    5 head, virgin 1-day female  (136) head, virgin 4-day female  (107) head, virgin 20-day female  (109) head, mated 1-day female  (131) head, mated 4-day female  (129) head, mated 20-day female  (92) head, mated 1-day male  (175) head, mated 4-day male  (171) head, mated 20-day male  (183) salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    0 digestive system, larvae L3 wandering  (58) digestive system, 1-day adult  (72) digestive system, 4-day adult  (63) digestive system, 20-day adult  (35) fat body, larvae L3 wandering    2 fat body, white prepupae    0 fat body, pupae P8    1 carcass, larvae L3 wandering    6 carcass, 1-day adult  (86) carcass, 4-day adult  (75) carcass, 20-day adult  (61) ovary, virgin 4-day female    1 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    2 central nervous system, pupae P8    5 head, virgin 1-day female  136 head, virgin 4-day female  107 head, virgin 20-day female  109 head, mated 1-day female  131 head, mated 4-day female  129 head, mated 20-day female    92 head, mated 1-day male  (175) head, mated 4-day male  (171) head, mated 20-day male  (183) salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    58 digestive system, 1-day adult    72 digestive system, 4-day adult    63 digestive system, 20-day adult    35 fat body, larvae L3 wandering    2 fat body, white prepupae    0 fat body, pupae P8    1 carcass, larvae L3 wandering    6 carcass, 1-day adult    86 carcass, 4-day adult    75 carcass, 20-day adult    61 ovary, virgin 4-day female    1 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    2 central nervous system, pupae P8    5 head, virgin 1-day female    136 head, virgin 4-day female    107 head, virgin 20-day female    109 head, mated 1-day female    131 head, mated 4-day female    129 head, mated 20-day female    92 head, mated 1-day male    175 head, mated 4-day male    171 head, mated 20-day male    183 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    58 digestive system, 1-day adult    72 digestive system, 4-day adult    63 digestive system, 20-day adult    35 fat body, larvae L3 wandering    2 fat body, white prepupae    0 fat body, pupae P8    1 carcass, larvae L3 wandering    6 carcass, 1-day adult    86 carcass, 4-day adult    75 carcass, 20-day adult    61 ovary, virgin 4-day female    1 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 18-24 hour embryonic stages, during late pupal stages, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    8 embryo 06-08hr    3 embryo 08-10hr    3 embryo 10-12hr    5 embryo 12-14hr    10 embryo 14-16hr    9 embryo 16-18hr    12 embryo 18-20hr    26 embryo 20-22hr    55 embryo 22-24hr    73 larva L1    15 larva L2    27 larva L3 12hr old    15 larva L3 puffstage 1-2    33 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    18 white prepupae new    3 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    3 pupae 3d postWPP    19 pupae 4d postWPP    126 adult male 01day    56 adult male 05day    45 adult male 30day    37 adult female 01day    37 adult female 05day    22 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    8 embryo 06-08hr    3 embryo 08-10hr    3 embryo 10-12hr    5 embryo 12-14hr    10 embryo 14-16hr    9 embryo 16-18hr    12 embryo 18-20hr  26 embryo 20-22hr  (55) embryo 22-24hr  (73) larva L1    15 larva L2  (27) larva L3 12hr old    15 larva L3 puffstage 1-2  (33) larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    18 white prepupae new    3 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    3 pupae 3d postWPP    19 pupae 4d postWPP  (126) adult male 01day  (56) adult male 05day  (45) adult male 30day  (37) adult female 01day  (37) adult female 05day    22 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    8 embryo 06-08hr    3 embryo 08-10hr    3 embryo 10-12hr    5 embryo 12-14hr    10 embryo 14-16hr    9 embryo 16-18hr    12 embryo 18-20hr    26 embryo 20-22hr    55 embryo 22-24hr    73 larva L1    15 larva L2    27 larva L3 12hr old    15 larva L3 puffstage 1-2    33 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    18 white prepupae new    3 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    3 pupae 3d postWPP    19 pupae 4d postWPP  (126) adult male 01day    56 adult male 05day    45 adult male 30day    37 adult female 01day    37 adult female 05day    22 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    8 embryo 06-08hr    3 embryo 08-10hr    3 embryo 10-12hr    5 embryo 12-14hr    10 embryo 14-16hr    9 embryo 16-18hr    12 embryo 18-20hr    26 embryo 20-22hr    55 embryo 22-24hr    73 larva L1    15 larva L2    27 larva L3 12hr old    15 larva L3 puffstage 1-2    33 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    18 white prepupae new    3 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    3 pupae 3d postWPP    19 pupae 4d postWPP    126 adult male 01day    56 adult male 05day    45 adult male 30day    37 adult female 01day    37 adult female 05day    22 adult female 30day    18 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    8 embryo 06-08hr    3 embryo 08-10hr    3 embryo 10-12hr    5 embryo 12-14hr    10 embryo 14-16hr    9 embryo 16-18hr    12 embryo 18-20hr    26 embryo 20-22hr    55 embryo 22-24hr    73 larva L1    15 larva L2    27 larva L3 12hr old    15 larva L3 puffstage 1-2    33 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    18 white prepupae new    3 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    3 pupae 3d postWPP    19 pupae 4d postWPP    126 adult male 01day    56 adult male 05day    45 adult male 30day    37 adult female 01day    37 adult female 05day    22 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    8 embryo 06-08hr    3 embryo 08-10hr    3 embryo 10-12hr    5 embryo 12-14hr    10 embryo 14-16hr    9 embryo 16-18hr    12 embryo 18-20hr  26 embryo 20-22hr  (55) embryo 22-24hr  (73) larva L1    15 larva L2  27 larva L3 12hr old    15 larva L3 puffstage 1-2  (33) larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    18 white prepupae new    3 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    3 pupae 3d postWPP    19 pupae 4d postWPP  (126) adult male 01day  (56) adult male 05day  (45) adult male 30day  (37) adult female 01day  (37) adult female 05day    22 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    8 embryo 06-08hr    3 embryo 08-10hr    3 embryo 10-12hr    5 embryo 12-14hr    10 embryo 14-16hr    9 embryo 16-18hr    12 embryo 18-20hr    26 embryo 20-22hr    55 embryo 22-24hr    73 larva L1    15 larva L2    27 larva L3 12hr old    15 larva L3 puffstage 1-2    33 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    18 white prepupae new    3 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    3 pupae 3d postWPP    19 pupae 4d postWPP  126 adult male 01day    56 adult male 05day    45 adult male 30day    37 adult female 01day    37 adult female 05day    22 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    8 embryo 06-08hr    3 embryo 08-10hr    3 embryo 10-12hr    5 embryo 12-14hr    10 embryo 14-16hr    9 embryo 16-18hr    12 embryo 18-20hr    26 embryo 20-22hr    55 embryo 22-24hr    73 larva L1    15 larva L2    27 larva L3 12hr old    15 larva L3 puffstage 1-2    33 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    18 white prepupae new    3 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    3 pupae 3d postWPP    19 pupae 4d postWPP    126 adult male 01day    56 adult male 05day    45 adult male 30day    37 adult female 01day    37 adult female 05day    22 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    62 Schneider line 2 Sg4    2 embryonic 1182-4H    0 embryonic GM2    3 embryonic Kc167    1 embryonic S1    2 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    17 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (62) Schneider line 2 Sg4    2 embryonic 1182-4H    0 embryonic GM2    3 embryonic Kc167    1 embryonic S1    2 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    17 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    62 Schneider line 2 Sg4    2 embryonic 1182-4H    0 embryonic GM2    3 embryonic Kc167    1 embryonic S1    2 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    17 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    62 Schneider line 2 Sg4    2 embryonic 1182-4H    0 embryonic GM2    3 embryonic Kc167    1 embryonic S1    2 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    17 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    62 Schneider line 2 Sg4    2 embryonic 1182-4H    0 embryonic GM2    3 embryonic Kc167    1 embryonic S1    2 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    17 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (62) Schneider line 2 Sg4    2 embryonic 1182-4H    0 embryonic GM2    3 embryonic Kc167    1 embryonic S1    2 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    17 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    62 Schneider line 2 Sg4    2 embryonic 1182-4H    0 embryonic GM2    3 embryonic Kc167    1 embryonic S1    2 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    17 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    62 Schneider line 2 Sg4    2 embryonic 1182-4H    0 embryonic GM2    3 embryonic Kc167    1 embryonic S1    2 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    17 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    21 cold shock, 4-day adult    15 heat shock, 4-day adult    30 Cadmium 50 mM 6 hrs, larvae L3    23 Cadmium 50 mM 12 hrs, larvae L3    29 Cadmium 50 mM 48 hrs, 4-day adult    29 Cadmium 100 mM 48 hrs, 4-day adult    39 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    34 Ethanol 2.5% 3 hrs, larvae L3    30 Ethanol 5% 3 hrs, larvae L3    86 Ethanol 10% 3 hrs, larvae L3    26 Caffeine 1.5 mg/ml 4 hrs, larvae L3    51 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    33 Caffeine 25 mg/ml 48 hrs, 4-day adult    19 Paraquat 5 mM 48 hrs, 4-day adult    57 Paraquat 10 mM 48 hrs, 4-day adult    63 Rotenone 2 μg 12 hrs, larvae L3    22 Rotenone 8 μg 12 hrs, larvae L3    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    21 cold shock, 4-day adult    15 heat shock, 4-day adult  (30) Cadmium 50 mM 6 hrs, larvae L3    23 Cadmium 50 mM 12 hrs, larvae L3  (29) Cadmium 50 mM 48 hrs, 4-day adult  (29) Cadmium 100 mM 48 hrs, 4-day adult  (39) Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult  (34) Ethanol 2.5% 3 hrs, larvae L3  (30) Ethanol 5% 3 hrs, larvae L3  (86) Ethanol 10% 3 hrs, larvae L3  26 Caffeine 1.5 mg/ml 4 hrs, larvae L3  (51) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (33) Caffeine 25 mg/ml 48 hrs, 4-day adult    19 Paraquat 5 mM 48 hrs, 4-day adult  (57) Paraquat 10 mM 48 hrs, 4-day adult  (63) Rotenone 2 μg 12 hrs, larvae L3    22 Rotenone 8 μg 12 hrs, larvae L3    24 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    21 cold shock, 4-day adult    15 heat shock, 4-day adult    30 Cadmium 50 mM 6 hrs, larvae L3    23 Cadmium 50 mM 12 hrs, larvae L3    29 Cadmium 50 mM 48 hrs, 4-day adult    29 Cadmium 100 mM 48 hrs, 4-day adult    39 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    34 Ethanol 2.5% 3 hrs, larvae L3    30 Ethanol 5% 3 hrs, larvae L3    86 Ethanol 10% 3 hrs, larvae L3    26 Caffeine 1.5 mg/ml 4 hrs, larvae L3    51 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    33 Caffeine 25 mg/ml 48 hrs, 4-day adult    19 Paraquat 5 mM 48 hrs, 4-day adult    57 Paraquat 10 mM 48 hrs, 4-day adult    63 Rotenone 2 μg 12 hrs, larvae L3    22 Rotenone 8 μg 12 hrs, larvae L3    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    21 cold shock, 4-day adult    15 heat shock, 4-day adult    30 Cadmium 50 mM 6 hrs, larvae L3    23 Cadmium 50 mM 12 hrs, larvae L3    29 Cadmium 50 mM 48 hrs, 4-day adult    29 Cadmium 100 mM 48 hrs, 4-day adult    39 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    34 Ethanol 2.5% 3 hrs, larvae L3    30 Ethanol 5% 3 hrs, larvae L3    86 Ethanol 10% 3 hrs, larvae L3    26 Caffeine 1.5 mg/ml 4 hrs, larvae L3    51 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    33 Caffeine 25 mg/ml 48 hrs, 4-day adult    19 Paraquat 5 mM 48 hrs, 4-day adult    57 Paraquat 10 mM 48 hrs, 4-day adult    63 Rotenone 2 μg 12 hrs, larvae L3    22 Rotenone 8 μg 12 hrs, larvae L3    24 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    21 cold shock, 4-day adult    15 heat shock, 4-day adult    30 Cadmium 50 mM 6 hrs, larvae L3    23 Cadmium 50 mM 12 hrs, larvae L3    29 Cadmium 50 mM 48 hrs, 4-day adult    29 Cadmium 100 mM 48 hrs, 4-day adult    39 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    34 Ethanol 2.5% 3 hrs, larvae L3    30 Ethanol 5% 3 hrs, larvae L3    86 Ethanol 10% 3 hrs, larvae L3    26 Caffeine 1.5 mg/ml 4 hrs, larvae L3    51 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    33 Caffeine 25 mg/ml 48 hrs, 4-day adult    19 Paraquat 5 mM 48 hrs, 4-day adult    57 Paraquat 10 mM 48 hrs, 4-day adult    63 Rotenone 2 μg 12 hrs, larvae L3    22 Rotenone 8 μg 12 hrs, larvae L3    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    21 cold shock, 4-day adult    15 heat shock, 4-day adult  30 Cadmium 50 mM 6 hrs, larvae L3    23 Cadmium 50 mM 12 hrs, larvae L3  29 Cadmium 50 mM 48 hrs, 4-day adult  29 Cadmium 100 mM 48 hrs, 4-day adult  (39) Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult  (34) Ethanol 2.5% 3 hrs, larvae L3  30 Ethanol 5% 3 hrs, larvae L3  (86) Ethanol 10% 3 hrs, larvae L3  26 Caffeine 1.5 mg/ml 4 hrs, larvae L3  (51) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (33) Caffeine 25 mg/ml 48 hrs, 4-day adult    19 Paraquat 5 mM 48 hrs, 4-day adult  (57) Paraquat 10 mM 48 hrs, 4-day adult  (63) Rotenone 2 μg 12 hrs, larvae L3    22 Rotenone 8 μg 12 hrs, larvae L3    24 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    21 cold shock, 4-day adult    15 heat shock, 4-day adult    30 Cadmium 50 mM 6 hrs, larvae L3    23 Cadmium 50 mM 12 hrs, larvae L3    29 Cadmium 50 mM 48 hrs, 4-day adult    29 Cadmium 100 mM 48 hrs, 4-day adult    39 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    34 Ethanol 2.5% 3 hrs, larvae L3    30 Ethanol 5% 3 hrs, larvae L3    86 Ethanol 10% 3 hrs, larvae L3    26 Caffeine 1.5 mg/ml 4 hrs, larvae L3    51 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    33 Caffeine 25 mg/ml 48 hrs, 4-day adult    19 Paraquat 5 mM 48 hrs, 4-day adult    57 Paraquat 10 mM 48 hrs, 4-day adult    63 Rotenone 2 μg 12 hrs, larvae L3    22 Rotenone 8 μg 12 hrs, larvae L3    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    21 cold shock, 4-day adult    15 heat shock, 4-day adult    30 Cadmium 50 mM 6 hrs, larvae L3    23 Cadmium 50 mM 12 hrs, larvae L3    29 Cadmium 50 mM 48 hrs, 4-day adult    29 Cadmium 100 mM 48 hrs, 4-day adult    39 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    34 Ethanol 2.5% 3 hrs, larvae L3    30 Ethanol 5% 3 hrs, larvae L3    86 Ethanol 10% 3 hrs, larvae L3    26 Caffeine 1.5 mg/ml 4 hrs, larvae L3    51 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    33 Caffeine 25 mg/ml 48 hrs, 4-day adult    19 Paraquat 5 mM 48 hrs, 4-day adult    57 Paraquat 10 mM 48 hrs, 4-day adult    63 Rotenone 2 μg 12 hrs, larvae L3    22 Rotenone 8 μg 12 hrs, larvae L3    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_20 mE1_20_mRNA_expression_cluster_16
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039321 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10550-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG10550GD271 Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of CG10550 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG10550 Class Mutagen Stocks Known lesion CG10550GD271 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG10550KK103827 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6202 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD271} NA P{KK103827} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 1 unique term )
	There is no information supporting a biological process or cellular component term for this gene. (Based on a review of available data on: 2010-10-21)
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function
CV term Evidence References
transferase activity, transferring phosphorus-containing groups inferred from electronic annotation with InterPro:IPR011009 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG10550 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67977 DroID - A comprehensive database of gene and protein interactions. • FBgn0039321 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43061
Orthologs
OrthoDB Orthologs (28) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6PZJSD Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search EOG6M384G Arthropod inclusive ortholog search EOG6J6Q5T Metazoa inclusive ortholog search EOG6T1WF6
Orthologs in Drosophila Species (EOG6PZJSD)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG10550     Drosophila simulans   Dsim\GD18211 Y   Drosophila sechellia   Dsec\GM17728 Y   Drosophila erecta   Dere\GG12261 Y   Drosophila yakuba   Dyak\GE10712 Y   Drosophila ananassae   Dana\GF17421     Drosophila ananassae   Dana\GF17422 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA27378 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA10389     Drosophila persimilis   Dper\GL22098     Drosophila persimilis   Dper\GL22099 Y   Drosophila willistoni   Dwil\GK14332     Drosophila willistoni   Dwil\GK14333     Drosophila virilis   Dvir\GJ23758 Y   Drosophila mojavensis   Dmoj\GI22569 Y   Drosophila grimshawi   Dgri\GH19368     Drosophila grimshawi   Dgri\GH19367     Drosophila grimshawi   Dgri\GH19366
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (EOG6M384G)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG012457 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH10148 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH26726 Y Pediculus humanus Human body louse  Phum\PHUM202540 Y
Orthologs in non-Insect Arthropods (EOG6J6Q5T)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\caf1 Y
Orthologs in non-Arthropod Metazoa (EOG6T1WF6)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\T16G1.3 Y Caenorhabditis elegans Nematode  Cele\E02C12.12 Y Caenorhabditis elegans Nematode  Cele\Y11D7A.8 Y Caenorhabditis elegans Nematode  Cele\F20D6.5 Y Caenorhabditis elegans Nematode  Cele\C29F7.1 Y
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (9) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD18211 Drosophila sechellia Dsec\GM17728 Drosophila erecta Dere\GG12261 Drosophila yakuba Dyak\GE10712 Drosophila ananassae Dana\GF17422 Drosophila pseudoobscura pseudoobscura Dpse\GA27378 Drosophila persimilis Dper\GL22099 Drosophila virilis Dvir\GJ23758 Drosophila mojavensis Dmoj\GI22569
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
VDRC	v106064 P{KK103827}VIE-260B v24486 w1118; P{GD271}v24486/CyO
Genomic Clones ( 2 )
	BACR06L08 BACR10P10 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 45 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH16930
Other clones	FI19804 GH06013
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT24786 GH07246 GH09324 GH10756 GH18121 GH19902 GH23127 GH23217 GH23601 RE02971 RE35372 RE43531 RE43559 RE54076 RH41641 RH69929 SD20513 SD20574 SD24051
Other clones	37891 CK01.141A.G6 CK01.143A.D3 EC260005 EK116959 EK156022 EP01051 GH06482 RM01046 RM01146 RM01246 RM01346 RM01746 RP001001802 RP001009672 RP001010502 RP001017145 RP001034963 RP001040800 RP001045583 RP001046092 RP001048705 RP001049435
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0039321 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43061
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_143123 NM_170218 NM_170219 RefSeq (Proteins) • NP_651380 NP_733097 NP_733098 DDBJ / EMBL / GenBank • AAF56450 AAF56451 AAK92940 AAN14048 AI386741 AW940641 AY051516 Entrez Gene - A searchable database of RefSeq genes. • 43061 UniProtKB/TrEMBL • Q9VBS7 Q961M0
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • CHK kinase-like (IPR015897) Protein of unknown function DUF227 (IPR004119) Protein kinase-like domain (IPR011009)
Linkouts
	BioGRID - A database of protein and genetic interactions • 67977 DroID - A comprehensive database of gene and protein interactions. • FBgn0039321 DRSC - Results from RNAi screens. • FBgn0039321 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039321 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10550-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0039321 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43061 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43061 modMine - Data generated by the modENCODE project. • FBgn0039321
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG10550 (Keleman et al., 2009.8.5, Wasbrough et al., 2010)
Name Synonym
Secondary FlyBase IDs
References ( 14 )
Supplementary material	Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] Khanna et al., 2010, BMC Genomics 11(1): Towards a membrane proteome in Drosophila: a method for the isolation of plasma membrane. [FBrf0210978] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Wasbrough et al., 2010, J. Proteomics 73(11): Supplemental Table 1. Mass spectrometry data. [FBrf0213252] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]
FlyBase analysis	FlyBase Curators, 2010-, Gene Ontology (GO) annotation review. Gene Ontology (GO) annotation review. [FBrf0216433] FlyBase Curators, 2002-, Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. [FBrf0159398]