• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • CytoSearch
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Downloads:
  • Precomputed files
  • Archived data
  • Releases (FTP)
  • Genomes (FTP)
  • AAA data (FTP)
  • Lists:
  • Transposons (Dmel)
  • Transposons (other)
  • Vectors & Constructs
  • Anatomical Terms
  • Map Conversion
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Other links:
  • BDGP
  • DGRC
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\CHKov2

General Information
Symbol	Dmel\CHKov2	Species	D. melanogaster
Name	CHKov2	Annotation symbol	CG10675
Feature type	protein_coding_gene	FlyBase ID	FBgn0039328
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	96D1-96D1	Sequence location	3R:21,155,252..21,156,924 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene CHKov2 is referred to in FlyBase by the symbol Dmel\CHKov2 (CG10675, FBgn0039328). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: transferase activity, transferring phosphorus-containing groups. The biological processes in which it is involved are not known. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: CHK kinase-like; Protein kinase-like domain; Protein of unknown function DUF227. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed during late larval stages, at stages throughout the pupal period, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult salivary gland, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult crop, adult hindgut, larval/adult Malpighian tubules, adult heart, larval salivary gland, larval trachea. Comments on Affy2 ProbeSet: ProbeSet 1638852_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CHKov2. Gene sequence location is 3R:21155252..21156924.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	References Magwire et al., 2011, PLoS Genet. 7(10): e1002337 Controlled Vocabulary Terms transferase activity, transferring phosphorus-containing groups Sequence features BKN23332 HFA14262
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 96D1-96D1   Limits computationally determined from genome sequence between P{PZ}Aats-gln05461 and P{EP}EP3354
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CHKov2 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CHKov2-RA FBtr0084849  NM_143130   1449   409
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CHKov2-PA   FBpp0084223   47.9   409   5.21     NP_651387   AAF56458
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein of unknown function DUF227 (IPR004119) Protein kinase-like domain (IPR011009) CHK kinase-like (IPR015897)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA803419   AA804040   AE014297 AAF56458   AI238598   AI405476   AI513317   AY058384 AAL13613   BI242685   CA805097   FE863665   FE863717   FE863896   FE863984
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VBS0
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0039328    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0039328 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed during late larval stages, at stages throughout the pupal period, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0039328 expression level Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    5 embryo 04-06hr    6 embryo 06-08hr    20 embryo 08-10hr    51 embryo 10-12hr    148 embryo 12-14hr    387 embryo 14-16hr    158 embryo 16-18hr    212 embryo 18-20hr    173 embryo 20-22hr    94 embryo 22-24hr    190 larva L1    53 larva L2    73 larva L3 12hr old    204 larva L3 puffstage 1-2    376 larva L3 puffstage 3-6    508 larva L3 puffstage 7-9    790 white prepupae new    961 white prepupae 12hr    346 white prepupae 24hr    255 pupae 2d postWPP    271 pupae 3d postWPP    482 pupae 4d postWPP    273 adult male 01day    852 adult male 05day    659 adult male 30day    592 adult female 01day    288 adult female 05day    190 adult female 30day    154 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    5 embryo 04-06hr    6 embryo 06-08hr    20 embryo 08-10hr    51 embryo 10-12hr  (148) embryo 12-14hr  (387) embryo 14-16hr  (158) embryo 16-18hr  (212) embryo 18-20hr  (173) embryo 20-22hr    94 embryo 22-24hr  (190) larva L1    53 larva L2    73 larva L3 12hr old  (204) larva L3 puffstage 1-2  (376) larva L3 puffstage 3-6  (508) larva L3 puffstage 7-9  (790) white prepupae new  (961) white prepupae 12hr  (346) white prepupae 24hr  (255) pupae 2d postWPP  (271) pupae 3d postWPP  (482) pupae 4d postWPP  (273) adult male 01day  (852) adult male 05day  (659) adult male 30day  (592) adult female 01day  (288) adult female 05day  (190) adult female 30day  (154) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    5 embryo 04-06hr    6 embryo 06-08hr    20 embryo 08-10hr    51 embryo 10-12hr    148 embryo 12-14hr    387 embryo 14-16hr    158 embryo 16-18hr    212 embryo 18-20hr    173 embryo 20-22hr    94 embryo 22-24hr    190 larva L1    53 larva L2    73 larva L3 12hr old    204 larva L3 puffstage 1-2    376 larva L3 puffstage 3-6    508 larva L3 puffstage 7-9    790 white prepupae new    961 white prepupae 12hr    346 white prepupae 24hr    255 pupae 2d postWPP    271 pupae 3d postWPP    482 pupae 4d postWPP    273 adult male 01day    852 adult male 05day    659 adult male 30day    592 adult female 01day    288 adult female 05day    190 adult female 30day    154 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    5 embryo 04-06hr    6 embryo 06-08hr    20 embryo 08-10hr    51 embryo 10-12hr    148 embryo 12-14hr    387 embryo 14-16hr    158 embryo 16-18hr    212 embryo 18-20hr    173 embryo 20-22hr    94 embryo 22-24hr    190 larva L1    53 larva L2    73 larva L3 12hr old    204 larva L3 puffstage 1-2    376 larva L3 puffstage 3-6    508 larva L3 puffstage 7-9    790 white prepupae new    961 white prepupae 12hr    346 white prepupae 24hr    255 pupae 2d postWPP    271 pupae 3d postWPP    482 pupae 4d postWPP    273 adult male 01day    852 adult male 05day    659 adult male 30day    592 adult female 01day    288 adult female 05day    190 adult female 30day    154 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    5 embryo 04-06hr    6 embryo 06-08hr    20 embryo 08-10hr    51 embryo 10-12hr    148 embryo 12-14hr    387 embryo 14-16hr    158 embryo 16-18hr    212 embryo 18-20hr    173 embryo 20-22hr    94 embryo 22-24hr    190 larva L1    53 larva L2    73 larva L3 12hr old    204 larva L3 puffstage 1-2    376 larva L3 puffstage 3-6    508 larva L3 puffstage 7-9    790 white prepupae new    961 white prepupae 12hr    346 white prepupae 24hr    255 pupae 2d postWPP    271 pupae 3d postWPP    482 pupae 4d postWPP    273 adult male 01day    852 adult male 05day    659 adult male 30day    592 adult female 01day    288 adult female 05day    190 adult female 30day    154 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0039328 expression level Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    5 embryo 04-06hr    6 embryo 06-08hr    20 embryo 08-10hr    51 embryo 10-12hr    148 embryo 12-14hr    387 embryo 14-16hr    158 embryo 16-18hr    212 embryo 18-20hr    173 embryo 20-22hr    94 embryo 22-24hr    190 larva L1    53 larva L2    73 larva L3 12hr old    204 larva L3 puffstage 1-2    376 larva L3 puffstage 3-6    508 larva L3 puffstage 7-9    790 white prepupae new    961 white prepupae 12hr    346 white prepupae 24hr    255 pupae 2d postWPP    271 pupae 3d postWPP    482 pupae 4d postWPP    273 adult male 01day    852 adult male 05day    659 adult male 30day    592 adult female 01day    288 adult female 05day    190 adult female 30day    154 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    5 embryo 04-06hr    6 embryo 06-08hr    20 embryo 08-10hr    51 embryo 10-12hr  (148) embryo 12-14hr  (387) embryo 14-16hr  (158) embryo 16-18hr  (212) embryo 18-20hr  (173) embryo 20-22hr    94 embryo 22-24hr  (190) larva L1    53 larva L2    73 larva L3 12hr old  (204) larva L3 puffstage 1-2  (376) larva L3 puffstage 3-6  (508) larva L3 puffstage 7-9  (790) white prepupae new  (961) white prepupae 12hr  (346) white prepupae 24hr  (255) pupae 2d postWPP  (271) pupae 3d postWPP  (482) pupae 4d postWPP  (273) adult male 01day  (852) adult male 05day  (659) adult male 30day  (592) adult female 01day  (288) adult female 05day  (190) adult female 30day  (154) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    5 embryo 04-06hr    6 embryo 06-08hr    20 embryo 08-10hr    51 embryo 10-12hr    148 embryo 12-14hr    387 embryo 14-16hr    158 embryo 16-18hr    212 embryo 18-20hr    173 embryo 20-22hr    94 embryo 22-24hr    190 larva L1    53 larva L2    73 larva L3 12hr old    204 larva L3 puffstage 1-2    376 larva L3 puffstage 3-6    508 larva L3 puffstage 7-9    790 white prepupae new    961 white prepupae 12hr    346 white prepupae 24hr    255 pupae 2d postWPP    271 pupae 3d postWPP    482 pupae 4d postWPP    273 adult male 01day    852 adult male 05day    659 adult male 30day    592 adult female 01day    288 adult female 05day    190 adult female 30day    154 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    5 embryo 04-06hr    6 embryo 06-08hr    20 embryo 08-10hr    51 embryo 10-12hr    148 embryo 12-14hr    387 embryo 14-16hr    158 embryo 16-18hr    212 embryo 18-20hr    173 embryo 20-22hr    94 embryo 22-24hr    190 larva L1    53 larva L2    73 larva L3 12hr old    204 larva L3 puffstage 1-2    376 larva L3 puffstage 3-6    508 larva L3 puffstage 7-9    790 white prepupae new    961 white prepupae 12hr    346 white prepupae 24hr    255 pupae 2d postWPP    271 pupae 3d postWPP    482 pupae 4d postWPP    273 adult male 01day    852 adult male 05day    659 adult male 30day    592 adult female 01day    288 adult female 05day    190 adult female 30day    154 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    5 embryo 04-06hr    6 embryo 06-08hr    20 embryo 08-10hr    51 embryo 10-12hr    148 embryo 12-14hr    387 embryo 14-16hr    158 embryo 16-18hr    212 embryo 18-20hr    173 embryo 20-22hr    94 embryo 22-24hr    190 larva L1    53 larva L2    73 larva L3 12hr old    204 larva L3 puffstage 1-2    376 larva L3 puffstage 3-6    508 larva L3 puffstage 7-9    790 white prepupae new    961 white prepupae 12hr    346 white prepupae 24hr    255 pupae 2d postWPP    271 pupae 3d postWPP    482 pupae 4d postWPP    273 adult male 01day    852 adult male 05day    659 adult male 30day    592 adult female 01day    288 adult female 05day    190 adult female 30day    154 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0039328    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0039328 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult salivary gland, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult crop, adult hindgut, larval/adult Malpighian tubules, adult heart, larval salivary gland, larval trachea. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0039328 expression level Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut no informative data Larval Hindgut    91.2 Larval Malpighian Tubules    294.7 Larval Fat Body no informative data Larval Salivary Gland    127.3 Larval Trachea    203.325 Larval Carcass    73.7 Adult Head    82.6 Adult Eye    128.425 Adult Brain    47.9 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    232.6 Adult Midgut no informative data Adult Hindgut    176.4 Adult Malpighian Tubules    392.3 Adult Fat Body no informative data Adult Salivary Gland    641.4 Adult Heart    104.675 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    8.8 Adult Testis no informative data Adult Male Accessory Gland    1544.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut no informative data Larval Hindgut    91.2 Larval Malpighian Tubules    294.7 Larval Fat Body no informative data Larval Salivary Gland    127.3 Larval Trachea    203.325 Larval Carcass    73.7 Adult Head    82.6 Adult Eye    128.425 Adult Brain    47.9 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    232.6 Adult Midgut no informative data Adult Hindgut    176.4 Adult Malpighian Tubules    392.3 Adult Fat Body no informative data Adult Salivary Gland  (641.4) Adult Heart    104.675 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    8.8 Adult Testis no informative data Adult Male Accessory Gland  (1544.4) Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut no informative data Larval Hindgut    91.2 Larval Malpighian Tubules    294.7 Larval Fat Body no informative data Larval Salivary Gland    127.3 Larval Trachea    203.325 Larval Carcass    73.7 Adult Head    82.6 Adult Eye    128.425 Adult Brain    47.9 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    232.6 Adult Midgut no informative data Adult Hindgut    176.4 Adult Malpighian Tubules    392.3 Adult Fat Body no informative data Adult Salivary Gland    641.4 Adult Heart    104.675 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    8.8 Adult Testis no informative data Adult Male Accessory Gland  (1544.4) Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut no informative data Larval Hindgut    91.2 Larval Malpighian Tubules    294.7 Larval Fat Body no informative data Larval Salivary Gland    127.3 Larval Trachea    203.325 Larval Carcass    73.7 Adult Head    82.6 Adult Eye    128.425 Adult Brain    47.9 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    232.6 Adult Midgut no informative data Adult Hindgut    176.4 Adult Malpighian Tubules    392.3 Adult Fat Body no informative data Adult Salivary Gland    641.4 Adult Heart    104.675 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    8.8 Adult Testis no informative data Adult Male Accessory Gland    1544.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0039328 expression level Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut no informative data Larval Hindgut    91.2 Larval Malpighian Tubules    294.7 Larval Fat Body no informative data Larval Salivary Gland    127.3 Larval Trachea    203.325 Larval Carcass    73.7 Adult Head    82.6 Adult Eye    128.425 Adult Brain    47.9 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    232.6 Adult Midgut no informative data Adult Hindgut    176.4 Adult Malpighian Tubules    392.3 Adult Fat Body no informative data Adult Salivary Gland    641.4 Adult Heart    104.675 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    8.8 Adult Testis no informative data Adult Male Accessory Gland    1544.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut no informative data Larval Hindgut    91.2 Larval Malpighian Tubules    294.7 Larval Fat Body no informative data Larval Salivary Gland    127.3 Larval Trachea    203.325 Larval Carcass    73.7 Adult Head    82.6 Adult Eye    128.425 Adult Brain    47.9 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    232.6 Adult Midgut no informative data Adult Hindgut    176.4 Adult Malpighian Tubules    392.3 Adult Fat Body no informative data Adult Salivary Gland  641.4 Adult Heart    104.675 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    8.8 Adult Testis no informative data Adult Male Accessory Gland  (1544.4) Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut no informative data Larval Hindgut    91.2 Larval Malpighian Tubules    294.7 Larval Fat Body no informative data Larval Salivary Gland    127.3 Larval Trachea    203.325 Larval Carcass    73.7 Adult Head    82.6 Adult Eye    128.425 Adult Brain    47.9 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    232.6 Adult Midgut no informative data Adult Hindgut    176.4 Adult Malpighian Tubules    392.3 Adult Fat Body no informative data Adult Salivary Gland    641.4 Adult Heart    104.675 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    8.8 Adult Testis no informative data Adult Male Accessory Gland  1544.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut no informative data Larval Hindgut    91.2 Larval Malpighian Tubules    294.7 Larval Fat Body no informative data Larval Salivary Gland    127.3 Larval Trachea    203.325 Larval Carcass    73.7 Adult Head    82.6 Adult Eye    128.425 Adult Brain    47.9 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    232.6 Adult Midgut no informative data Adult Hindgut    176.4 Adult Malpighian Tubules    392.3 Adult Fat Body no informative data Adult Salivary Gland    641.4 Adult Heart    104.675 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    8.8 Adult Testis no informative data Adult Male Accessory Gland    1544.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut no informative data Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion no informative data Adult Crop     Adult Midgut no informative data Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body no informative data Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary     Adult Testis no informative data Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    82.6   NA  Eye    128.425   NA  Brain    47.9   no informative data  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    no informative data   NA  Crop    232.6   no informative data  Midgut    no informative data   91.2  Hindgut    176.4   294.7  Malpighian Tubules    392.3   no informative data  Fat Body    no informative data   127.3  Salivary Gland    641.4   NA  Heart    104.675   203.325  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    8.8   NA  Testis    no informative data   NA  Male Accessory Gland    1544.4   73.7  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_04
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039328 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10675-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CHKov2GD6713 Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of CHKov2 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CHKov2 Class Mutagen Stocks Known lesion CHKov2GD6713 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CHKov2KK103140 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6202 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD6713} NA P{KK103140} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{SUPor-P}CHKov1KG02238 NA
Gene Ontology: Function, Process & Cellular Component ( 1 unique term )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function
CV term Evidence References
transferase activity, transferring phosphorus-containing groups inferred from electronic annotation with InterPro:IPR011009 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CHKov2 allele Gene References
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0039328 DroID - A comprehensive database of gene and protein interactions. • FBgn0039328
Orthologs
Genome-wide drosophilid orthologs	Dana\GF17412 Dere\GG12253 Dmoj\GI22564 Dper\GL22088 Dpse\GA27374 Dsec\GM17719 Dsim\CHKov2 Dvir\GJ23753 Dwil\GK14326 Dyak\GE10703
Curated drosophilid orthologs	Dpse\GA10486   Dsim\CHKov2 (Aminetzach et al., 2005, Aminetzach et al., 2005.6.7)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • CBP34769 Caenorhabditis briggsae (nematode) RP13025 Caenorhabditis remanei (nematode) RP13383 Caenorhabditis remanei (nematode) RP26946 Caenorhabditis remanei (nematode) RP36765 Caenorhabditis remanei (nematode) RP43384 Caenorhabditis remanei (nematode) PP20108 Pristionchus pacificus (nematode) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0228549 FBgn0216332 FBgn0216329 FBgn0210850 FBgn0084777 FBgn0172627 FBgn0248741 FBgn0243924 FBgn0159680 FBgn0145292 FBgn0126825 FBgn0126820 FBgn0104545 FBgn0094430
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
VDRC	v102615 P{KK103140}VIE-260B v45100 w1118; P{GD6713}v45100 v45099 w1118; P{GD6713}v45099/TM3
Genomic Clones ( 2 )
	BACR06L08 BACR10P10 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 11 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH14673
Other clones	DPiM_GH14673
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH25484 GM12620 GM13128 RE40083
Other clones	ESG0116c.B21_B06 RM07737 RM07837 RM08037 RM08137
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0039328 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43068
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: CHKov2 CG10675 (Aminetzach et al., 2005)
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_143130 RefSeq (Proteins) • NP_651387 DDBJ / EMBL / GenBank • AAF56458 AAL13613 AI238598 AI513317 AY058384 Entrez Gene - A searchable database of RefSeq genes. • 43068 UniProtKB/TrEMBL • Q9VBS0
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein of unknown function DUF227 (IPR004119) Protein kinase-like domain (IPR011009) CHK kinase-like (IPR015897)
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0039328 DroID - A comprehensive database of gene and protein interactions. • FBgn0039328 DRSC - Results from RNAi screens. • FBgn0039328 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039328 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10675-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0039328 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43068 InParanoid A subset of ortholog calls from InParanoid. • CBP34769 Caenorhabditis briggsae (nematode) RP13025 Caenorhabditis remanei (nematode) RP13383 Caenorhabditis remanei (nematode) RP26946 Caenorhabditis remanei (nematode) RP36765 Caenorhabditis remanei (nematode) RP43384 Caenorhabditis remanei (nematode) PP20108 Pristionchus pacificus (nematode) modMine - Data generated by the modENCODE project. • FBgn0039328 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0228549 FBgn0216332 FBgn0216329 FBgn0210850 FBgn0084777 FBgn0172627 FBgn0248741 FBgn0243924 FBgn0159680 FBgn0145292 FBgn0126825 FBgn0126820 FBgn0104545 FBgn0094430
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	CG10675 (Aminetzach et al., 2005, Keleman et al., 2009.8.5) CHKov2
Name Synonym	CHKov2
Secondary FlyBase IDs
References ( 14 )
Research paper	Magwire et al., 2011, PLoS Genet. 7(10): e1002337 Successive Increases in the Resistance of Drosophila to Viral Infection through a Transposon Insertion Followed by a Duplication. [FBrf0216506] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Aminetzach et al., 2005, Science 309(5735): 764--767 Pesticide resistance via transposition-mediated adaptive gene truncation in Drosophila. [FBrf0188316]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
DNA/RNA sequence record	Aminetzach et al., 2005.6.7, GenBank/EMBL/DDBJ: DQ087673 Drosophila simulans CHKov2 (CG10675) gene, partial cds; and CHKov1-like (CG10618) gene, complete sequence. [FBrf0199343]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]