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Gene Dmel\XNP

General Information
Symbol	Dmel\XNP	Species	D. melanogaster
Name	XNP	Annotation symbol	CG4548
Feature type	protein_coding_gene	FlyBase ID	FBgn0039338
Gene Model Status	Current	Stock availability	11 publicly available
Also Known As	dATRX, dXNP
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	96E1-96E2	Sequence location	3R:21,303,590..21,308,556 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene XNP is referred to in FlyBase by the symbol Dmel\XNP (CG4548, FBgn0039338). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: ATPase activity. There is experimental evidence that it is involved in the biological process: regulation of JNK cascade; heterochromatin organization involved in chromatin silencing; induction of apoptosis; axon guidance; glial cell migration; nervous system development; chromosome organization; DNA replication-independent nucleosome assembly. 21 alleles are reported. The phenotypes of these alleles are annotated with: mushroom body; embryonic/larval glial cell; posterior commissure; adult thorax; Kenyon cell; interface glial cell; longitudinal connective; microchaeta; scutellum; anterior commissure. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Helicase, C-terminal; Helicase, superfamily 1/2, ATP-binding domain; SNF2-related. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult thoracico-abdominal ganglion, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1630882_s_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of XNP. Gene sequence location is 3R:21303590..21308556.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03	Alleles XNP[C1]
FB2013_02	Controlled Vocabulary Terms DNA replication-independent nucleosome assembly
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 96E1-96E2   Limits computationally determined from genome sequence between P{PZ}Aats-gln05461 and P{EP}EP3354
Experimentally Determined Cytological Location
Cytogenetic map Notes References 96C-96D     (Cardoso, 1999.12.20)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\XNP for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.43 Gene model reviewed during 5.48 DGC clone appears problematic (SD07188): incomplete CDS; DGC:LD28477 okay.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) XNP-RA FBtr0084837  NM_170228   4493   1311 XNP-RB FBtr0084838  NM_143141   4557   1311
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein XNP-PA   FBpp0084212   148.2   1311   8.66     NP_733107   AAF56471 XNP-PB   FBpp0084213   148.2   1311   8.66     NP_651398   AAN14055
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • SNF2-related (IPR000330) Helicase, C-terminal (IPR001650) Helicase, superfamily 1/2, ATP-binding domain (IPR014001) P-loop containing nucleoside triphosphate hydrolase (IPR027417)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141876   AA441386   AA817261   AA820126   AA940600   AA949914   AA952136   AE014297 AAF56471   AE014297 AAN14055   AF217802 AAG40586   AI515474   AI515776   AI516687   AI519587   AI534383   AI541807   AQ025132   AW942892   AW944486   AY058592 AAL13821   AY069822 AAL39967   BF487841   BG634611   BG639052   BI215134   BI361863   BI482026   BI633664   CK659283   CO177230   CO178503   CO188348   CO272311   CO279390   CO310706   CO311062   CO325690   CO325920   CO329671   EC051491   EC051590   EC052080   EC055047   EC055799   EC055926   EC056482   EC062233   EC064760   EC069645   EC198749   EC202105   EC212321   EC218603   EC232341   EC244102   EC250507   EC251537   GH747926   GH749245   GH750351   GH752452   GH752469   GH756162   GH757517   GH759125   GH759747   GH760924   GH772077   GH776104   GH781486   GH785443   GH794366   GH795989   GH801065   GH801733   GH806479   GH808402   GH808709   GH821593   GH827766   GH830381   GH831918   GH835645   GH837906   GH839175   GH841772   GH844853   GH846300   GH847149   GH849973   GH851378   GH851705   GH852903   GH853484   GH853782   GH854114   GH859307   GH863807   GH865379   GH868397   GH873288   GH874666   GH876418   GH885941   GH888201   GH899036   GH913817   GH914145   GH914790   GH918906   GH927361   GH934500   GH934862   GH935339   GH936558
UniProtKB/Swiss-Prot	Q9GQN5
UniProtKB/TrEMBL	Q8T9C9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism | ubiquitous   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   antennal anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage central brain anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage dorsal head epidermis anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage visual anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage organism | ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   antennal primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium central brain primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium visual primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium dorsal head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium lateral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium ventral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium organism | ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 11 -- 12   central brain primordium   (Fisher et al., 2012) embryonic central brain neuron   (Fisher et al., 2012) lateral cord neuron   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic central brain neuron   (Fisher et al., 2012) embryonic/larval nervous system   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Dorus et al., 2006)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
beta-heterochromatin inferred from direct assay (Emelyanov et al., 2010) chromosome, centromeric region inferred from direct assay (Bassett et al., 2008) polytene chromosome inferred from direct assay (Bassett et al., 2008, Valadez-Graham et al., 2012)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult thoracico-abdominal ganglion, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    782.825 Larval Midgut    127.4 Larval Hindgut    196.7 Larval Malpighian Tubules    186.1 Larval Fat Body    138.7 Larval Salivary Gland    275.1 Larval Trachea    264.9 Larval Carcass    250.45 Adult Head    200 Adult Eye    150.4 Adult Brain    521.1 Adult Thoracic-Abdominal Ganglion    432.1 Adult Crop    240.2 Adult Midgut    117.9 Adult Hindgut    188.1 Adult Malpighian Tubules    144.2 Adult Fat Body    154.4 Adult Salivary Gland    198.1 Adult Heart    113.525 Adult VirginFemale Spermatheca    204.9 Adult InseminatedFemale Spermatheca    198.2 Adult Ovary    459.2 Adult Testis    177.9 Adult Male Accessory Gland    218.5 Adult Carcass    151.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (782.825) Larval Midgut    127.4 Larval Hindgut    196.7 Larval Malpighian Tubules    186.1 Larval Fat Body    138.7 Larval Salivary Gland    275.1 Larval Trachea    264.9 Larval Carcass    250.45 Adult Head    200 Adult Eye    150.4 Adult Brain  521.1 Adult Thoracic-Abdominal Ganglion    432.1 Adult Crop    240.2 Adult Midgut    117.9 Adult Hindgut    188.1 Adult Malpighian Tubules    144.2 Adult Fat Body    154.4 Adult Salivary Gland    198.1 Adult Heart    113.525 Adult VirginFemale Spermatheca    204.9 Adult InseminatedFemale Spermatheca    198.2 Adult Ovary    459.2 Adult Testis    177.9 Adult Male Accessory Gland    218.5 Adult Carcass    151.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    782.825 Larval Midgut    127.4 Larval Hindgut    196.7 Larval Malpighian Tubules    186.1 Larval Fat Body    138.7 Larval Salivary Gland    275.1 Larval Trachea    264.9 Larval Carcass    250.45 Adult Head    200 Adult Eye    150.4 Adult Brain    521.1 Adult Thoracic-Abdominal Ganglion    432.1 Adult Crop    240.2 Adult Midgut    117.9 Adult Hindgut    188.1 Adult Malpighian Tubules    144.2 Adult Fat Body    154.4 Adult Salivary Gland    198.1 Adult Heart    113.525 Adult VirginFemale Spermatheca    204.9 Adult InseminatedFemale Spermatheca    198.2 Adult Ovary    459.2 Adult Testis    177.9 Adult Male Accessory Gland    218.5 Adult Carcass    151.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    782.825 Larval Midgut    127.4 Larval Hindgut    196.7 Larval Malpighian Tubules    186.1 Larval Fat Body    138.7 Larval Salivary Gland    275.1 Larval Trachea    264.9 Larval Carcass    250.45 Adult Head    200 Adult Eye    150.4 Adult Brain    521.1 Adult Thoracic-Abdominal Ganglion    432.1 Adult Crop    240.2 Adult Midgut    117.9 Adult Hindgut    188.1 Adult Malpighian Tubules    144.2 Adult Fat Body    154.4 Adult Salivary Gland    198.1 Adult Heart    113.525 Adult VirginFemale Spermatheca    204.9 Adult InseminatedFemale Spermatheca    198.2 Adult Ovary    459.2 Adult Testis    177.9 Adult Male Accessory Gland    218.5 Adult Carcass    151.7 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    782.825 Larval Midgut    127.4 Larval Hindgut    196.7 Larval Malpighian Tubules    186.1 Larval Fat Body    138.7 Larval Salivary Gland    275.1 Larval Trachea    264.9 Larval Carcass    250.45 Adult Head    200 Adult Eye    150.4 Adult Brain    521.1 Adult Thoracic-Abdominal Ganglion    432.1 Adult Crop    240.2 Adult Midgut    117.9 Adult Hindgut    188.1 Adult Malpighian Tubules    144.2 Adult Fat Body    154.4 Adult Salivary Gland    198.1 Adult Heart    113.525 Adult VirginFemale Spermatheca    204.9 Adult InseminatedFemale Spermatheca    198.2 Adult Ovary    459.2 Adult Testis    177.9 Adult Male Accessory Gland    218.5 Adult Carcass    151.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  782.825 Larval Midgut    127.4 Larval Hindgut    196.7 Larval Malpighian Tubules    186.1 Larval Fat Body    138.7 Larval Salivary Gland    275.1 Larval Trachea    264.9 Larval Carcass    250.45 Adult Head    200 Adult Eye    150.4 Adult Brain  521.1 Adult Thoracic-Abdominal Ganglion    432.1 Adult Crop    240.2 Adult Midgut    117.9 Adult Hindgut    188.1 Adult Malpighian Tubules    144.2 Adult Fat Body    154.4 Adult Salivary Gland    198.1 Adult Heart    113.525 Adult VirginFemale Spermatheca    204.9 Adult InseminatedFemale Spermatheca    198.2 Adult Ovary    459.2 Adult Testis    177.9 Adult Male Accessory Gland    218.5 Adult Carcass    151.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    782.825 Larval Midgut    127.4 Larval Hindgut    196.7 Larval Malpighian Tubules    186.1 Larval Fat Body    138.7 Larval Salivary Gland    275.1 Larval Trachea    264.9 Larval Carcass    250.45 Adult Head    200 Adult Eye    150.4 Adult Brain    521.1 Adult Thoracic-Abdominal Ganglion    432.1 Adult Crop    240.2 Adult Midgut    117.9 Adult Hindgut    188.1 Adult Malpighian Tubules    144.2 Adult Fat Body    154.4 Adult Salivary Gland    198.1 Adult Heart    113.525 Adult VirginFemale Spermatheca    204.9 Adult InseminatedFemale Spermatheca    198.2 Adult Ovary    459.2 Adult Testis    177.9 Adult Male Accessory Gland    218.5 Adult Carcass    151.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    782.825 Larval Midgut    127.4 Larval Hindgut    196.7 Larval Malpighian Tubules    186.1 Larval Fat Body    138.7 Larval Salivary Gland    275.1 Larval Trachea    264.9 Larval Carcass    250.45 Adult Head    200 Adult Eye    150.4 Adult Brain    521.1 Adult Thoracic-Abdominal Ganglion    432.1 Adult Crop    240.2 Adult Midgut    117.9 Adult Hindgut    188.1 Adult Malpighian Tubules    144.2 Adult Fat Body    154.4 Adult Salivary Gland    198.1 Adult Heart    113.525 Adult VirginFemale Spermatheca    204.9 Adult InseminatedFemale Spermatheca    198.2 Adult Ovary    459.2 Adult Testis    177.9 Adult Male Accessory Gland    218.5 Adult Carcass    151.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    200   NA  Eye    150.4   NA  Brain    521.1   782.825  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    432.1   NA  Crop    240.2   127.4  Midgut    117.9   196.7  Hindgut    188.1   186.1  Malpighian Tubules    144.2   138.7  Fat Body    154.4   275.1  Salivary Gland    198.1   NA  Heart    113.525   264.9  Trachea    NA   NA  VirginFemale Spermatheca    204.9   NA  InseminatedFemale Spermatheca    198.2   NA  Ovary    459.2   NA  Testis    177.9   NA  Male Accessory Gland    218.5   250.45  Carcass    151.7 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    47 central nervous system, larvae L3    69 central nervous system, pupae P8    39 head, virgin 1-day female    15 head, virgin 4-day female    18 head, virgin 20-day female    16 head, mated 1-day female    16 head, mated 4-day female    16 head, mated 20-day female    14 head, mated 1-day male    22 head, mated 4-day male    28 head, mated 20-day male    33 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    7 digestive system, 4-day adult    10 digestive system, 20-day adult    8 fat body, larvae L3 wandering    5 fat body, white prepupae    15 fat body, pupae P8    7 carcass, larvae L3 wandering    40 carcass, 1-day adult    11 carcass, 4-day adult    14 carcass, 20-day adult    11 ovary, virgin 4-day female    60 ovary, mated 4-day female    57 testis, mated 4-day male    19 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (47) central nervous system, larvae L3  (69) central nervous system, pupae P8  (39) head, virgin 1-day female    15 head, virgin 4-day female    18 head, virgin 20-day female    16 head, mated 1-day female    16 head, mated 4-day female    16 head, mated 20-day female    14 head, mated 1-day male    22 head, mated 4-day male  (28) head, mated 20-day male  (33) salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    7 digestive system, 4-day adult    10 digestive system, 20-day adult    8 fat body, larvae L3 wandering    5 fat body, white prepupae    15 fat body, pupae P8    7 carcass, larvae L3 wandering  (40) carcass, 1-day adult    11 carcass, 4-day adult    14 carcass, 20-day adult    11 ovary, virgin 4-day female  (60) ovary, mated 4-day female  (57) testis, mated 4-day male    19 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    47 central nervous system, larvae L3    69 central nervous system, pupae P8    39 head, virgin 1-day female    15 head, virgin 4-day female    18 head, virgin 20-day female    16 head, mated 1-day female    16 head, mated 4-day female    16 head, mated 20-day female    14 head, mated 1-day male    22 head, mated 4-day male    28 head, mated 20-day male    33 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    7 digestive system, 4-day adult    10 digestive system, 20-day adult    8 fat body, larvae L3 wandering    5 fat body, white prepupae    15 fat body, pupae P8    7 carcass, larvae L3 wandering    40 carcass, 1-day adult    11 carcass, 4-day adult    14 carcass, 20-day adult    11 ovary, virgin 4-day female    60 ovary, mated 4-day female    57 testis, mated 4-day male    19 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    47 central nervous system, larvae L3    69 central nervous system, pupae P8    39 head, virgin 1-day female    15 head, virgin 4-day female    18 head, virgin 20-day female    16 head, mated 1-day female    16 head, mated 4-day female    16 head, mated 20-day female    14 head, mated 1-day male    22 head, mated 4-day male    28 head, mated 20-day male    33 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    7 digestive system, 4-day adult    10 digestive system, 20-day adult    8 fat body, larvae L3 wandering    5 fat body, white prepupae    15 fat body, pupae P8    7 carcass, larvae L3 wandering    40 carcass, 1-day adult    11 carcass, 4-day adult    14 carcass, 20-day adult    11 ovary, virgin 4-day female    60 ovary, mated 4-day female    57 testis, mated 4-day male    19 accessory gland, mated 4-day male    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    47 central nervous system, larvae L3    69 central nervous system, pupae P8    39 head, virgin 1-day female    15 head, virgin 4-day female    18 head, virgin 20-day female    16 head, mated 1-day female    16 head, mated 4-day female    16 head, mated 20-day female    14 head, mated 1-day male    22 head, mated 4-day male    28 head, mated 20-day male    33 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    7 digestive system, 4-day adult    10 digestive system, 20-day adult    8 fat body, larvae L3 wandering    5 fat body, white prepupae    15 fat body, pupae P8    7 carcass, larvae L3 wandering    40 carcass, 1-day adult    11 carcass, 4-day adult    14 carcass, 20-day adult    11 ovary, virgin 4-day female    60 ovary, mated 4-day female    57 testis, mated 4-day male    19 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (47) central nervous system, larvae L3  (69) central nervous system, pupae P8  (39) head, virgin 1-day female    15 head, virgin 4-day female    18 head, virgin 20-day female    16 head, mated 1-day female    16 head, mated 4-day female    16 head, mated 20-day female    14 head, mated 1-day male    22 head, mated 4-day male  28 head, mated 20-day male  (33) salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    7 digestive system, 4-day adult    10 digestive system, 20-day adult    8 fat body, larvae L3 wandering    5 fat body, white prepupae    15 fat body, pupae P8    7 carcass, larvae L3 wandering  (40) carcass, 1-day adult    11 carcass, 4-day adult    14 carcass, 20-day adult    11 ovary, virgin 4-day female  (60) ovary, mated 4-day female  (57) testis, mated 4-day male    19 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    47 central nervous system, larvae L3    69 central nervous system, pupae P8    39 head, virgin 1-day female    15 head, virgin 4-day female    18 head, virgin 20-day female    16 head, mated 1-day female    16 head, mated 4-day female    16 head, mated 20-day female    14 head, mated 1-day male    22 head, mated 4-day male    28 head, mated 20-day male    33 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    7 digestive system, 4-day adult    10 digestive system, 20-day adult    8 fat body, larvae L3 wandering    5 fat body, white prepupae    15 fat body, pupae P8    7 carcass, larvae L3 wandering    40 carcass, 1-day adult    11 carcass, 4-day adult    14 carcass, 20-day adult    11 ovary, virgin 4-day female    60 ovary, mated 4-day female    57 testis, mated 4-day male    19 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    47 central nervous system, larvae L3    69 central nervous system, pupae P8    39 head, virgin 1-day female    15 head, virgin 4-day female    18 head, virgin 20-day female    16 head, mated 1-day female    16 head, mated 4-day female    16 head, mated 20-day female    14 head, mated 1-day male    22 head, mated 4-day male    28 head, mated 20-day male    33 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    7 digestive system, 4-day adult    10 digestive system, 20-day adult    8 fat body, larvae L3 wandering    5 fat body, white prepupae    15 fat body, pupae P8    7 carcass, larvae L3 wandering    40 carcass, 1-day adult    11 carcass, 4-day adult    14 carcass, 20-day adult    11 ovary, virgin 4-day female    60 ovary, mated 4-day female    57 testis, mated 4-day male    19 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    64 embryo 02-04hr    103 embryo 04-06hr    123 embryo 06-08hr    82 embryo 08-10hr    69 embryo 10-12hr    41 embryo 12-14hr    36 embryo 14-16hr    33 embryo 16-18hr    24 embryo 18-20hr    15 embryo 20-22hr    18 embryo 22-24hr    21 larva L1    18 larva L2    14 larva L3 12hr old    11 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    24 larva L3 puffstage 7-9    27 white prepupae new    28 white prepupae 12hr    38 white prepupae 24hr    46 pupae 2d postWPP    28 pupae 3d postWPP    15 pupae 4d postWPP    12 adult male 01day    18 adult male 05day    22 adult male 30day    21 adult female 01day    26 adult female 05day    42 adult female 30day    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (64) embryo 02-04hr  (103) embryo 04-06hr  (123) embryo 06-08hr  (82) embryo 08-10hr  (69) embryo 10-12hr  (41) embryo 12-14hr  (36) embryo 14-16hr  (33) embryo 16-18hr    24 embryo 18-20hr    15 embryo 20-22hr    18 embryo 22-24hr    21 larva L1    18 larva L2    14 larva L3 12hr old    11 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    24 larva L3 puffstage 7-9  (27) white prepupae new  (28) white prepupae 12hr  (38) white prepupae 24hr  (46) pupae 2d postWPP  (28) pupae 3d postWPP    15 pupae 4d postWPP    12 adult male 01day    18 adult male 05day    22 adult male 30day    21 adult female 01day  26 adult female 05day  (42) adult female 30day  (42) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    64 embryo 02-04hr  103 embryo 04-06hr  (123) embryo 06-08hr    82 embryo 08-10hr    69 embryo 10-12hr    41 embryo 12-14hr    36 embryo 14-16hr    33 embryo 16-18hr    24 embryo 18-20hr    15 embryo 20-22hr    18 embryo 22-24hr    21 larva L1    18 larva L2    14 larva L3 12hr old    11 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    24 larva L3 puffstage 7-9    27 white prepupae new    28 white prepupae 12hr    38 white prepupae 24hr    46 pupae 2d postWPP    28 pupae 3d postWPP    15 pupae 4d postWPP    12 adult male 01day    18 adult male 05day    22 adult male 30day    21 adult female 01day    26 adult female 05day    42 adult female 30day    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    64 embryo 02-04hr    103 embryo 04-06hr    123 embryo 06-08hr    82 embryo 08-10hr    69 embryo 10-12hr    41 embryo 12-14hr    36 embryo 14-16hr    33 embryo 16-18hr    24 embryo 18-20hr    15 embryo 20-22hr    18 embryo 22-24hr    21 larva L1    18 larva L2    14 larva L3 12hr old    11 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    24 larva L3 puffstage 7-9    27 white prepupae new    28 white prepupae 12hr    38 white prepupae 24hr    46 pupae 2d postWPP    28 pupae 3d postWPP    15 pupae 4d postWPP    12 adult male 01day    18 adult male 05day    22 adult male 30day    21 adult female 01day    26 adult female 05day    42 adult female 30day    42 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    64 embryo 02-04hr    103 embryo 04-06hr    123 embryo 06-08hr    82 embryo 08-10hr    69 embryo 10-12hr    41 embryo 12-14hr    36 embryo 14-16hr    33 embryo 16-18hr    24 embryo 18-20hr    15 embryo 20-22hr    18 embryo 22-24hr    21 larva L1    18 larva L2    14 larva L3 12hr old    11 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    24 larva L3 puffstage 7-9    27 white prepupae new    28 white prepupae 12hr    38 white prepupae 24hr    46 pupae 2d postWPP    28 pupae 3d postWPP    15 pupae 4d postWPP    12 adult male 01day    18 adult male 05day    22 adult male 30day    21 adult female 01day    26 adult female 05day    42 adult female 30day    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (64) embryo 02-04hr  (103) embryo 04-06hr  (123) embryo 06-08hr  (82) embryo 08-10hr  (69) embryo 10-12hr  (41) embryo 12-14hr  (36) embryo 14-16hr  (33) embryo 16-18hr    24 embryo 18-20hr    15 embryo 20-22hr    18 embryo 22-24hr    21 larva L1    18 larva L2    14 larva L3 12hr old    11 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    24 larva L3 puffstage 7-9  27 white prepupae new  28 white prepupae 12hr  (38) white prepupae 24hr  (46) pupae 2d postWPP  28 pupae 3d postWPP    15 pupae 4d postWPP    12 adult male 01day    18 adult male 05day    22 adult male 30day    21 adult female 01day  26 adult female 05day  (42) adult female 30day  (42) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    64 embryo 02-04hr  103 embryo 04-06hr  123 embryo 06-08hr    82 embryo 08-10hr    69 embryo 10-12hr    41 embryo 12-14hr    36 embryo 14-16hr    33 embryo 16-18hr    24 embryo 18-20hr    15 embryo 20-22hr    18 embryo 22-24hr    21 larva L1    18 larva L2    14 larva L3 12hr old    11 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    24 larva L3 puffstage 7-9    27 white prepupae new    28 white prepupae 12hr    38 white prepupae 24hr    46 pupae 2d postWPP    28 pupae 3d postWPP    15 pupae 4d postWPP    12 adult male 01day    18 adult male 05day    22 adult male 30day    21 adult female 01day    26 adult female 05day    42 adult female 30day    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    64 embryo 02-04hr    103 embryo 04-06hr    123 embryo 06-08hr    82 embryo 08-10hr    69 embryo 10-12hr    41 embryo 12-14hr    36 embryo 14-16hr    33 embryo 16-18hr    24 embryo 18-20hr    15 embryo 20-22hr    18 embryo 22-24hr    21 larva L1    18 larva L2    14 larva L3 12hr old    11 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    24 larva L3 puffstage 7-9    27 white prepupae new    28 white prepupae 12hr    38 white prepupae 24hr    46 pupae 2d postWPP    28 pupae 3d postWPP    15 pupae 4d postWPP    12 adult male 01day    18 adult male 05day    22 adult male 30day    21 adult female 01day    26 adult female 05day    42 adult female 30day    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    71 Schneider line 2 Sg4    44 embryonic 1182-4H    56 embryonic GM2    35 embryonic Kc167    31 embryonic S1    45 embryonic S3    39 leg disc CME L1    59 wing disc CME-W2    37 wing disc ML-DmD8    39 wing disc ML-DmD9    45 wing disc ML-DmD16-c3    57 wing disc ML-DmD21    35 wing disc ML-DmD32    41 haltere disc ML-DmD17-c3    60 eye-antennal disc ML-DmD11    44 antennal disc ML-DmD20-c5    33 mixed discs ML-DmD4-c1    40 CNS ML-DmBG1-c1    53 CNS ML-DmBG2-c2    35 tumorous blood cells mbn2    38 ovary fGS/OSS    101 ovary OSC    81 ovary OSS    56 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (71) Schneider line 2 Sg4  (44) embryonic 1182-4H  (56) embryonic GM2  (35) embryonic Kc167  (31) embryonic S1  (45) embryonic S3  (39) leg disc CME L1  (59) wing disc CME-W2  (37) wing disc ML-DmD8  (39) wing disc ML-DmD9  (45) wing disc ML-DmD16-c3  (57) wing disc ML-DmD21  (35) wing disc ML-DmD32  (41) haltere disc ML-DmD17-c3  (60) eye-antennal disc ML-DmD11  (44) antennal disc ML-DmD20-c5  (33) mixed discs ML-DmD4-c1  (40) CNS ML-DmBG1-c1  (53) CNS ML-DmBG2-c2  (35) tumorous blood cells mbn2  (38) ovary fGS/OSS  (101) ovary OSC  (81) ovary OSS  (56) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    71 Schneider line 2 Sg4    44 embryonic 1182-4H    56 embryonic GM2    35 embryonic Kc167    31 embryonic S1    45 embryonic S3    39 leg disc CME L1    59 wing disc CME-W2    37 wing disc ML-DmD8    39 wing disc ML-DmD9    45 wing disc ML-DmD16-c3    57 wing disc ML-DmD21    35 wing disc ML-DmD32    41 haltere disc ML-DmD17-c3    60 eye-antennal disc ML-DmD11    44 antennal disc ML-DmD20-c5    33 mixed discs ML-DmD4-c1    40 CNS ML-DmBG1-c1    53 CNS ML-DmBG2-c2    35 tumorous blood cells mbn2    38 ovary fGS/OSS  101 ovary OSC    81 ovary OSS    56 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    71 Schneider line 2 Sg4    44 embryonic 1182-4H    56 embryonic GM2    35 embryonic Kc167    31 embryonic S1    45 embryonic S3    39 leg disc CME L1    59 wing disc CME-W2    37 wing disc ML-DmD8    39 wing disc ML-DmD9    45 wing disc ML-DmD16-c3    57 wing disc ML-DmD21    35 wing disc ML-DmD32    41 haltere disc ML-DmD17-c3    60 eye-antennal disc ML-DmD11    44 antennal disc ML-DmD20-c5    33 mixed discs ML-DmD4-c1    40 CNS ML-DmBG1-c1    53 CNS ML-DmBG2-c2    35 tumorous blood cells mbn2    38 ovary fGS/OSS    101 ovary OSC    81 ovary OSS    56 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    71 Schneider line 2 Sg4    44 embryonic 1182-4H    56 embryonic GM2    35 embryonic Kc167    31 embryonic S1    45 embryonic S3    39 leg disc CME L1    59 wing disc CME-W2    37 wing disc ML-DmD8    39 wing disc ML-DmD9    45 wing disc ML-DmD16-c3    57 wing disc ML-DmD21    35 wing disc ML-DmD32    41 haltere disc ML-DmD17-c3    60 eye-antennal disc ML-DmD11    44 antennal disc ML-DmD20-c5    33 mixed discs ML-DmD4-c1    40 CNS ML-DmBG1-c1    53 CNS ML-DmBG2-c2    35 tumorous blood cells mbn2    38 ovary fGS/OSS    101 ovary OSC    81 ovary OSS    56 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (71) Schneider line 2 Sg4  (44) embryonic 1182-4H  (56) embryonic GM2  (35) embryonic Kc167  31 embryonic S1  (45) embryonic S3  (39) leg disc CME L1  (59) wing disc CME-W2  (37) wing disc ML-DmD8  (39) wing disc ML-DmD9  (45) wing disc ML-DmD16-c3  (57) wing disc ML-DmD21  (35) wing disc ML-DmD32  (41) haltere disc ML-DmD17-c3  (60) eye-antennal disc ML-DmD11  (44) antennal disc ML-DmD20-c5  (33) mixed discs ML-DmD4-c1  (40) CNS ML-DmBG1-c1  (53) CNS ML-DmBG2-c2  (35) tumorous blood cells mbn2  (38) ovary fGS/OSS  (101) ovary OSC  (81) ovary OSS  (56) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    71 Schneider line 2 Sg4    44 embryonic 1182-4H    56 embryonic GM2    35 embryonic Kc167    31 embryonic S1    45 embryonic S3    39 leg disc CME L1    59 wing disc CME-W2    37 wing disc ML-DmD8    39 wing disc ML-DmD9    45 wing disc ML-DmD16-c3    57 wing disc ML-DmD21    35 wing disc ML-DmD32    41 haltere disc ML-DmD17-c3    60 eye-antennal disc ML-DmD11    44 antennal disc ML-DmD20-c5    33 mixed discs ML-DmD4-c1    40 CNS ML-DmBG1-c1    53 CNS ML-DmBG2-c2    35 tumorous blood cells mbn2    38 ovary fGS/OSS  101 ovary OSC    81 ovary OSS    56 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    71 Schneider line 2 Sg4    44 embryonic 1182-4H    56 embryonic GM2    35 embryonic Kc167    31 embryonic S1    45 embryonic S3    39 leg disc CME L1    59 wing disc CME-W2    37 wing disc ML-DmD8    39 wing disc ML-DmD9    45 wing disc ML-DmD16-c3    57 wing disc ML-DmD21    35 wing disc ML-DmD32    41 haltere disc ML-DmD17-c3    60 eye-antennal disc ML-DmD11    44 antennal disc ML-DmD20-c5    33 mixed discs ML-DmD4-c1    40 CNS ML-DmBG1-c1    53 CNS ML-DmBG2-c2    35 tumorous blood cells mbn2    38 ovary fGS/OSS    101 ovary OSC    81 ovary OSS    56 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    14 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult    40 Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult    30 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    37 Caffeine 25 mg/ml 48 hrs, 4-day adult    22 Paraquat 5 mM 48 hrs, 4-day adult    32 Paraquat 10 mM 48 hrs, 4-day adult    29 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    14 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult  (40) Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult  (30) Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3  (44) Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (37) Caffeine 25 mg/ml 48 hrs, 4-day adult    22 Paraquat 5 mM 48 hrs, 4-day adult  (32) Paraquat 10 mM 48 hrs, 4-day adult  (29) Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    14 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult    40 Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult    30 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    37 Caffeine 25 mg/ml 48 hrs, 4-day adult    22 Paraquat 5 mM 48 hrs, 4-day adult    32 Paraquat 10 mM 48 hrs, 4-day adult    29 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    14 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult    40 Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult    30 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    37 Caffeine 25 mg/ml 48 hrs, 4-day adult    22 Paraquat 5 mM 48 hrs, 4-day adult    32 Paraquat 10 mM 48 hrs, 4-day adult    29 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    14 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult    40 Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult    30 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    37 Caffeine 25 mg/ml 48 hrs, 4-day adult    22 Paraquat 5 mM 48 hrs, 4-day adult    32 Paraquat 10 mM 48 hrs, 4-day adult    29 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    14 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult  (40) Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult  30 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3  (44) Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (37) Caffeine 25 mg/ml 48 hrs, 4-day adult    22 Paraquat 5 mM 48 hrs, 4-day adult  32 Paraquat 10 mM 48 hrs, 4-day adult  29 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    14 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult    40 Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult    30 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    37 Caffeine 25 mg/ml 48 hrs, 4-day adult    22 Paraquat 5 mM 48 hrs, 4-day adult    32 Paraquat 10 mM 48 hrs, 4-day adult    29 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    14 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    23 Cadmium 100 mM 48 hrs, 4-day adult    40 Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult    30 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    44 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    37 Caffeine 25 mg/ml 48 hrs, 4-day adult    22 Paraquat 5 mM 48 hrs, 4-day adult    32 Paraquat 10 mM 48 hrs, 4-day adult    29 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_17 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • SD07188 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039338 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4548-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for XNP Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4Act5C.PI XNPEP635 partially lethal - majority die XNP2 XNP3 XNP4 partially lethal - majority die, with Scer\GAL4Act5C.PU XNPUY3132 partially lethal - majority die | recessive XNP5 viable XNP6 XNP7 XNP8 XNP9 XNP403 XNP406 viable, with Scer\GAL4pnr-MD237 XNPGD4562 Sterility Allele fertile XNP5 XNP6 XNP7 XNP8 XNP9 XNP403 XNP406 Other Phenotypes Allele neuroanatomy defective XNPdsRNA.Scer\UAS.WIZ neuroanatomy defective, with Scer\GAL47B XNPUY3132 neuroanatomy defective, with Scer\GAL4elav.PLu XNPdsRNA.Scer\UAS.WIZ XNPEP635 suppressor of variegation, with Dp(?;2)bwD, Scer\GAL4GMR.PF XNPEP635 suppressor of variegation, with P{hsp26-pt-T}39C-12 XNP3 suppressor of variegation (with XNP403), with Dp(?;2)bwD XNP406 suppressor of variegation (with XNP403), with In(1)wm4 XNP406 suppressor of variegation (with XNP406), with Dp(?;2)bwD XNP403 suppressor of variegation (with XNP406), with In(1)wm4 XNP403 suppressor of variegation | dominant, with Dp(?;2)bwD XNP403 XNP406 suppressor of variegation | dominant, with In(1)wm4 XNP403 suppressor of variegation | dominant, with In(1)wm4h XNP1 XNP2 XNP3 XNP4 suppressor of variegation | dominant, with P{hsp26-pt-T}39C-12 XNP1 suppressor of variegation | recessive XNP5 XNP6 visible, with Scer\GAL4ap-md544 XNPEP635 Phenotype manifest in Allele adult thorax, with Scer\GAL4ap-md544 XNPEP635 anterior commissure, with Scer\GAL4elav.PLu XNPEP635 embryonic/larval glial cell XNPdsRNA.Scer\UAS.WIZ interface glial cell XNPdsRNA.Scer\UAS.WIZ Kenyon cell, with Scer\GAL47B XNPUY3132 longitudinal connective, with Scer\GAL4elav.PLu XNPEP635 XNPdsRNA.Scer\UAS.WIZ microchaeta, with Scer\GAL4ap-md544 XNPEP635 mushroom body, with Scer\GAL47B XNPUY3132 posterior commissure, with Scer\GAL4elav.PLu XNPEP635 scutellum, with Scer\GAL4ap-md544 XNPEP635
Classical Alleles ( 14 )
For All Classical Alleles Show
Allele of XNP Class Mutagen Stocks Known lesion XNP1 Delta2-3 1 Yes XNP2 hypomorphic allele - genetic evidence Delta2-3 1 Yes XNP3 Delta2-3 1 Yes XNPEP635 P-element activity 1 Yes XNPUY3132 P-element activity 1 Yes XNP403 loss of function allele 0 -- XNP406 loss of function allele 0 -- XNP4 hypomorphic allele - genetic evidence Delta2-3 0 Yes XNP5 Delta2-3 0 Yes XNP6 Delta2-3 0 Yes XNP7 Delta2-3 0 Yes XNP8 Delta2-3 0 Yes XNP9 Delta2-3 0 Yes XNPC1 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Allele of XNP Class Mutagen Stocks Known lesion XNPGD4562 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes XNPHMS00683 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes XNPJF03380 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes XNPK495R.Scer\UAS.T:Ivir\HA1 in vitro construct - amino acid replacement 1 Yes XNPKK103859 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes XNPScer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 1 Yes XNPdsRNA.Scer\UAS.Sym in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes XNPdsRNA.Scer\UAS.WIZ in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6202 (Ryder, 2004.4.26) Df(3R)XNP1 (Bassett et al., 2008)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4562} NA P{KK103859} NA P{TRiP.HMS00683} NA P{TRiP.JF03380} NA P{UAS-XNP.HA} NA P{UAS-XNP.K495R.HA} NA P{UAS-XNP.RNAi.Sym} NA P{UAS-XNP.RNAi.WIZ} NA reporter construct P{XNP-lacZ.593} No
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}XNPEP635 NA P{GSV1}EP-51 NA P{Mae-UAS.6.11}XNPUY3132 NA
Gene Ontology: Function, Process & Cellular Component ( 18 unique terms )
Terms Based on Experimental Evidence ( 12 terms )
Molecular Function
CV term Evidence References
ATPase activity inferred from direct assay (Emelyanov et al., 2010)
Biological Process
CV term Evidence References
axon guidance inferred from mutant phenotype (Sun et al., 2006) chromosome organization inferred from mutant phenotype (Bassett et al., 2008) DNA replication-independent nucleosome assembly inferred from mutant phenotype (Schneiderman et al., 2012) glial cell migration inferred from mutant phenotype (Sun et al., 2006) heterochromatin organization involved in chromatin silencing inferred from mutant phenotype (Emelyanov et al., 2010) induction of apoptosis inferred from mutant phenotype (Lee et al., 2007) nervous system development inferred from mutant phenotype (Koizumi et al., 2007) regulation of JNK cascade inferred from genetic interaction with hep (Lee et al., 2007)
Cellular Component
CV term Evidence References
beta-heterochromatin inferred from direct assay (Emelyanov et al., 2010) chromosome, centromeric region inferred from direct assay (Bassett et al., 2008) polytene chromosome inferred from direct assay (Bassett et al., 2008, Valadez-Graham et al., 2012)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000330, InterPro:IPR001650 (FlyBase Curators et al., 2004-) DNA binding inferred from electronic annotation with InterPro:IPR000330 (FlyBase Curators et al., 2004-) DNA helicase activity non-traceable author statement (Cardoso, 1999.12.20) helicase activity inferred from electronic annotation with InterPro:IPR001650 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
transcription, DNA-dependent non-traceable author statement (Swiss-Prot Project Members, 2002.3.1)
Cellular Component
CV term Evidence References
nucleus non-traceable author statement (Swiss-Prot Project Members, 2002.3.1)
Sequence Ontology: Class of Gene
	gene_with_edited_transcript (Graveley et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
XNP - CkIIα anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) XNP - CkIIβ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) XNP - RpL7-like anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) XNP - Spt5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions XNP allele Gene References XNPEP635 pnr (Pena-Rangel et al., 2002) unspecified CG32137 (Sun et al., 2006) D1 (Sun et al., 2006) jigr1 (Sun et al., 2006) jing (Sun et al., 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67994 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0039338 DroID - A comprehensive database of gene and protein interactions. • FBgn0039338 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43080
Orthologs
OrthoDB Orthologs (55) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6X6CTP Dipteran inclusive ortholog search EOG6P2Q98 Insect inclusive ortholog search EOG6280WF Arthropod inclusive ortholog search EOG67PVMQ Metazoa inclusive ortholog search EOG679T0N
Orthologs in Drosophila Species (EOG6X6CTP)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\XNP     Drosophila simulans   Dsim\GD18194 Y   Drosophila sechellia   Dsec\GM10241 Y   Drosophila erecta   Dere\GG12244 Y   Drosophila yakuba   Dyak\GE10693 Y   Drosophila ananassae   Dana\GF18082 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA18248 Y   Drosophila persimilis   Dper\GL12501 Y   Drosophila willistoni   Dwil\GK12000 Y   Drosophila virilis   Dvir\GJ10883 Y   Drosophila mojavensis   Dmoj\GI10182 Y   Drosophila grimshawi   Dgri\GH18228 Y
Orthologs in non-Drosophila Dipterans (EOG6P2Q98)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL001141   Anopheles gambiae Malaria mosquito  Agam\AGAP002490   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ009998
Orthologs in non-Dipteran Insects (EOG6280WF)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB43562   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG010833   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG010834   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH14743   Atta cephalotes Leafcutter ant  Acep\ACEP24177   Camponotus floridanus Florida carpenter ant  Cflo\CFLO17562   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL16022   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL16024   Linepithema humile Argentine ant  Lhum\LH19247   Linepithema humile Argentine ant  Lhum\LH25762   Pogonomyrmex barbatus Red harvester ant  Pbar\PB18428   Solenopsis invicta Red fire ant  Sinv\SINV24032   Solenopsis invicta Red fire ant  Sinv\SINV24028   Acyrthosiphon pisum Pea aphid  Apim\ACYPI005035   Acyrthosiphon pisum Pea aphid  Apim\ACYPI000690   Bombyx mori Silkmoth  Bmor\BGIBMGA001852   Bombyx mori Silkmoth  Bmor\BGIBMGA008314   Pediculus humanus Human body louse  Phum\PHUM456670   Tribolium castaneum Red flour beetle  Tcas\TC009794
Orthologs in non-Insect Arthropods (EOG67PVMQ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\MnSOD   Daphnia pulex Water flea  Dpux\JGI_V11_188325   Ixodes scapularis Deer tick  Isca\ISCW009437   Ixodes scapularis Deer tick  Isca\ISCW007361
Orthologs in non-Arthropod Metazoa (EOG679T0N)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\rad-26 Y Caenorhabditis elegans Nematode  Cele\B0041.7 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_001388gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_025171gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_007773gn Y Danio rerio Zebrafish  Drer\OTTDARG00000032075 Y Danio rerio Zebrafish  Drer\ENSDARG00000063031 Y Xenopus tropicalis Western clawed frog  Xtro\rad54l2 Y Xenopus tropicalis Western clawed frog  Xtro\atrx Y Gallus gallus Domestic chicken  Ggal\RAD54L2 Y Gallus gallus Domestic chicken  Ggal\ATRX Y Mus musculus House mouse  Mmus\Rad54l2 Y Mus musculus House mouse  Mmus\Atrx Y Rattus norvegicus Norway rat  Rnor\Atrx Y Rattus norvegicus Norway rat  Rnor\Rad54l Y Homo sapiens Human  Hsap\ATRX Y Homo sapiens Human  Hsap\RAD54L2 Y
Human Orthologs (2)
Gene OMIM HGNC Hsap\ATRX     Hsap\RAD54L2
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD18194 Drosophila sechellia Dsec\GM10241 Drosophila erecta Dere\GG12244 Drosophila yakuba Dyak\GE10693 Drosophila ananassae Dana\GF18082 Drosophila pseudoobscura pseudoobscura Dpse\GA18248 Drosophila persimilis Dper\GL12501 Drosophila willistoni Dwil\GK12000 Drosophila virilis Dvir\GJ10883 Drosophila mojavensis Dmoj\GI10182 Drosophila grimshawi Dgri\GH18228
Stocks & Reagents
Stocks Listed in FlyBase ( 11 )
Bloomington	26645 w*; P{UAS-XNP.HA}3 26646 w*; P{UAS-XNP.K495R.HA}3 17188 w1118; P{EP}XNPEP635 26644 w*; XNP3/TM6B, Tb1 29444 y1 v1; P{TRiP.JF03380}attP2 26643 w*; XNP2/TM3, Sb1 Ser1 32894 y1 sc* v1; P{TRiP.HMS00683}attP2 7355 y1 w67c23; P{Mae-UAS.6.11}XNPUY3132 26642 w*; Df(3R)XNP1, XNP1/TM6B, Tb1
VDRC	v101568 P{KK103859}VIE-260B v10618 w1118; P{GD4562}v10618
Genomic Clones ( 1 )
	BACR03M22 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 107 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD28477 SD07188
Other clones	DPiM_LD28477
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT22906 AT30874 LD16301 LD21835 LD22475 LD22764 LD29209 LD39225 LD41445 LD47324 LP16939 RE21354 RE46247 RE64666 SD06988 SD27808
Other clones	8307 19033 20928 50103 70006 99611 100764 178130 CK01.65A.C10 CK01.71D.F3 CK02644 EC051491 EC051590 EC052080 EC055047 EC055799 EC055926 EC056482 EC251537 EK039261 EK052943 EK056917 EK106712 EK134219 EK197211 EK222326 EK223244 EK293401 EP02917 LD42659 RP003013683 RP003015413 RP003030119 RP003038227 RP003039732 RP003040327 RP003043926 RP003052010 RP003065975 RP003069171 RP003091205 RP003110736 RP003134356 RP003140013 RP003154136 RP003172982 RP003187320 RP003206082 RP003208109 RP003218849 RP003222922 RP003231969 RP003240072 RP003240157 RP003280951 RP003281081 RP003281767 RP003291374 RP003304558 RP003322616 RP003326805 RP003327081 RP003328276 RP003332558 RP003351174 RP003360370 RP003369876 RP003395222 RP003395378 RP003406596 RP003450227 RP003498816 RP003503118 RP003503502 RP003515315 RP003530962 RP003536045 RP003541232 RP003545457 RP003551313 RP003552267 RP003560809 RP003594978 RP003606162 RP003628213 RP003638832 RP003650315 RP003665105
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0039338 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43080
Antibody Information
	polyclonal (Schneiderman et al., 2009, Bassett et al., 2008, Emelyanov et al., 2010, Valadez-Graham et al., 2012)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: XNP CG4548 (FlyBase, 1996-)
Source for database merge of	Source for merge of: XNP EP635 (FlyBase, 1996-)
Additional comments	Source for identity of XNP CG4548 was sequence comparison (date:001220). (FlyBase, 1996-) Source for merge of XNP EP635 was that EP635 insertion is within XNP (and in the right orientation) (date:040519). (FlyBase, 1996-)
Other Comments
	One of 42 Drosophila genes identified as being most likely to reveal molecular and cellular mechanisms of nervous system development or plasticity relevant to human Mental Retardation disorders. (Inlow and Restifo, 2004)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_143141 NM_170228 RefSeq (Proteins) • NP_651398 NP_733107 DDBJ / EMBL / GenBank • AA949914 AAF56471 AAG40586 AAL13821 AAL39967 AAN14055 AF217802 AI534383 AQ025132 AW942892 AW944486 AY058592 AY069822 Entrez Gene - A searchable database of RefSeq genes. • 43080 UniProtKB/Swiss-Prot • Q9GQN5 UniProtKB/TrEMBL • Q8T9C9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • SNF2-related (IPR000330) Helicase, C-terminal (IPR001650) Helicase, superfamily 1/2, ATP-binding domain (IPR014001) P-loop containing nucleoside triphosphate hydrolase (IPR027417) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • SD07188
Linkouts
	BioGRID - A database of protein and genetic interactions • 67994 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0039338 DroID - A comprehensive database of gene and protein interactions. • FBgn0039338 DRSC - Results from RNAi screens. • FBgn0039338 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039338 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4548-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0039338 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43080 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43080 modMine - Data generated by the modENCODE project. • FBgn0039338
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	ATR-X/XNP (Sun et al., 2006) CG4548 (Sun et al., 2006, Molnar et al., 2006, Lee et al., 2007, Keleman et al., 2009.8.5, Schneiderman et al., 2009, Wang et al., 2004, Perkins et al., 2009, Schneiderman et al., 2010, Ni et al., 2010.12.1) DATR-X (Sun et al., 2006) dATRX (Bassett et al., 2008, Valadez-Graham et al., 2012) DATRX (Hong et al., 2009) dXNP (Lee et al., 2007, Hong et al., 2009) EP635   EP(3)0635 (Pena-Rangel et al., 2002) XNP (Parks and Muskavitch, 2009.2.5, Molnar et al., 2006, Dorus et al., 2006, Koizumi et al., 2007, Lee et al., 2012, Davis et al., 2011, Antao et al., 2012, Valadez-Graham et al., 2012) xnp (Schneiderman et al., 2009, Schneiderman et al., 2010, Emelyanov et al., 2010, Schneiderman et al., 2012) xnp/atr-x (Cardoso, 1999.12.20)
Name Synonym	XNP (Lee et al., 2007, Davis et al., 2011)
Secondary FlyBase IDs
	FBgn0062645
References ( 40 )
Generate a list of	All references relating to this gene ( 40 )
List References by type	Research paper  ( 19 ) Supplementary material  ( 5 ) Personal communication to FlyBase  ( 9 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Protein sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 6 )
	Antao et al., 2012, Mol. Cell. Biol. 32(12): 2170--2182 Protein Landscape at Drosophila melanogaster Telomere-Associated Sequence Repeats. [FBrf0218429] Krauchunas et al., 2012, Dev. Biol. 370(1): 125--134 Protein phosphorylation changes reveal new candidates in the regulation of egg activation and early embryogenesis in D. melanogaster. [FBrf0219342] Lee et al., 2012, Cell Death Differ. 19(7): 1109--1116 ATRX induction by mutant huntingtin via Cdx2 modulates heterochromatin condensation and pathology in Huntington's disease. [FBrf0219805] Schneiderman et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(48): 19721--19726 Nucleosome-depleted chromatin gaps recruit assembly factors for the H3.3 histone variant. [FBrf0220071] Valadez-Graham et al., 2012, Nucleic Acids Res. 40(4): 1460--1474 XNP/dATRX interacts with DREF in the chromatin to regulate gene expression. [FBrf0217551] Davis et al., 2011, BMC Dev. Biol. 11: 66 Identification of common and cell type specific LXXLL motif EcR cofactors using a bioinformatics refined candidate RNAi screen in Drosophila melanogaster cell lines. [FBrf0216830] Show all research papers ...