FlyBase Gene Report: Dmel\CG17197

PALMITOYLTRANSFERASES -: Palmitoyltransferases catalyze the post-translational addition of a palmitate moiety to a cysteine residue through a covalent thioester bond. (Adapted from FBrf0210485).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the GBrowse view of Dmel\CG17197 or the JBrowse view of Dmel\CG17197 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.48

gene_with_dicistronic_mRNA ; SO:0000722

Gene model reviewed during 5.54

Multiphase exon postulated: this gene shares a region of coding sequence with an overlapping gene, but different reading frames are utilized in the overlapping coding region.

Sequence Ontology: Class of Gene

gene_with_dicistronic_mRNA

(FlyBase Genome Annotators, 2013)

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CG17197-RB

FBtr0290204

NM_143168

1958

290

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

CG17197-PB

FBpp0288643

33.7

290

8.99

NP_651425

AAF56503

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Palmitoyltransferase, DHHC domain

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9VBM7

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG17197 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG17197_1

Linkouts

Gene Ontology (6 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

protein-cysteine S-palmitoyltransferase activity

inferred from biological aspect of ancestor with PANTHER:PTN000525256

(assigned by GO_Central )

(Gaudet et al., 2011)

inferred from sequence or structural similarity with SGD:S000004236

(Bannan et al., 2008)

Biological Process (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

peptidyl-L-cysteine S-palmitoylation

inferred from biological aspect of ancestor with PANTHER:PTN000525256

(assigned by GO_Central )

(Gaudet et al., 2011)

protein palmitoylation

inferred from sequence or structural similarity with SGD:S000004236

(Bannan et al., 2008)

protein targeting to membrane

inferred from biological aspect of ancestor with PANTHER:PTN000525256

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

endoplasmic reticulum

inferred from direct assay

(Bannan et al., 2008)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

endoplasmic reticulum

inferred from biological aspect of ancestor with PANTHER:PTN000525256

(assigned by GO_Central )

(Gaudet et al., 2011)

Golgi apparatus

inferred from biological aspect of ancestor with PANTHER:PTN000525256

(assigned by GO_Central )

(Gaudet et al., 2011)

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

embryonic/larval central nervous system

(Bannan et al., 2008)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | male

organism

(Bannan et al., 2008)

Additional Descriptive Data

Detected in male bodies but not female bodies by RT-PCR.

(Bannan et al., 2008)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

endoplasmic reticulum

inferred from direct assay

(Bannan et al., 2008)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CG17197 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CG17197

View exonic expression by tissue for Dmel\CG17197

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0039367

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0039367

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG17197-RA

Flygut - An atlas of the Drosophila adult midgut

FBgn0039367

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 0 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CG17197

Transgenic constructs containing regulatory region of CG17197

Deletions and Duplications ( 0 )

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

CG17197^GD279

viable, with Scer\GAL4^Mef2.PR

CG17197^GD279

viable, with Scer\GAL4^pnr-MD237

CG17197^GD279

viable, with Scer\GAL4^tin.CΔ4

CG17197^GD279

Other Phenotypes

Allele

visible, with Scer\GAL4^Bx-MS1096

CG17197^{UAS.ORF.GW.Tag:HA}

Phenotype manifest in

Allele

wing, with Scer\GAL4^Bx-MS1096

CG17197^{UAS.ORF.GW.Tag:HA}

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v7.1)

Homo sapiens (Human) (22)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\ZDHHC24

9 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v7.1)

Mus musculus (laboratory mouse) (22)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Zdhhc24

9 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (19)

Rnor\Zdhhc24

10 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Rnor\Zdhhc15

1 of 13

Rnor\Zdhhc18

1 of 13

Rnor\Zdhhc22

1 of 13

Xenopus tropicalis (Western clawed frog) (12)

Xtro\zdhhc24

6 of 12

Yes

Xtro\zdhhc7

2 of 12

Xtro\zdhhc8

2 of 12

Xtro\zdhhc21

2 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Xtro\zdhhc14

1 of 12

Xtro\zdhhc15

1 of 12

Xtro\zdhhc16

1 of 12

Danio rerio (Zebrafish) (29)

Drer\zdhhc24

8 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Drer\zdhhc12b

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (18)

Cele\dhhc-1

9 of 15

Yes

3 of 15

2 of 15

2 of 15

2 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Cele\F35F11.3

1 of 15

Yes

Cele\spe-10

1 of 15

Cele\spe-11

1 of 15

Yes

Cele\Y48A6B.8

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (15)

Atha\AT2G40990

1 of 9

Yes

Atha\AT3G04970

1 of 9

Yes

Atha\AT3G09320

1 of 9

Yes

Atha\AT3G18620

1 of 9

Yes

Atha\AT3G26935

1 of 9

Yes

Atha\AT3G48760

1 of 9

Yes

Atha\AT3G56920

1 of 9

Yes

Atha\AT3G56930

1 of 9

Yes

Atha\AT3G60800

1 of 9

Yes

Atha\AT4G00840

1 of 9

Yes

Atha\AT4G24630

1 of 9

Yes

Atha\AT5G04270

1 of 9

Yes

Atha\AT5G05070

1 of 9

Yes

Atha\AT5G41060

1 of 9

Yes

Atha\AT5G50020

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (4)

Scer\ERF2

2 of 15

Yes

Scer\PFA5

2 of 15

Yes

Scer\PFA3

1 of 15

Scer\SWF1

1 of 15

Schizosaccharomyces pombe (Fission yeast) (4)

Spom\erf2

1 of 12

Yes

Spom\pfa3

1 of 12

Yes

Spom\pfa5

1 of 12

Yes

Spom\swf1

1 of 12

Yes

Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190DH0 )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( None identified )

No non-Drosophilid orthologies identified

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0K90 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Danaus plexippus

Monarch butterfly

Dple\DPOGS211088-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS202465-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL012485

Apis florea

Little honeybee

Aflo\2497795268

Apis mellifera

Western honey bee

Amel\GB47212

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP17205

Bombus terrestris

Buff-tailed bumblebee

Bter\15212517

Linepithema humile

Argentine ant

Lhum\LH21242

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:0006e7

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG002030

Tribolium castaneum

Red flour beetle

Tcas\TC006858

Pediculus humanus

Human body louse

Phum\PHUM474970

Rhodnius prolixus

Kissing bug

Rpro\RPRC007465

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI55237

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_16586

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0KF2 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR006172

Strigamia maritima

European centipede

Smar\SMAR013540

Stegodyphus mimosarum

African social velvet spider

Smim\KFM74883.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM60521.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur22g01540

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_308301

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0RWR )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Zdhhc24

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000024982

Ciona intestinalis

Vase tunicate

Cint\LOC100180902

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v7.1)

Drosophila melanogaster (Fruit fly) (19)

Gene Symbol

Score

Source

Alignment

6 of 10

6 of 10

6 of 10

6 of 10

6 of 10

6 of 10

6 of 10

6 of 10

app

3 of 10

3 of 10

3 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ZDHHC24; zinc finger DHHC-type containing 24

9 of 15

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0039367

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-89

Cytogenetic map

96F2-96F2

Sequence location

3R:25,773,334..25,775,369 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

96F2-96F2

Limits computationally determined from genome sequence between P{PZ}l(3)rQ197^rQ197 and P{lacW}scrib^j7B3

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-89

(FlyBase, 2016)

3-86.8

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (6)

FlyORF

F003366

M{UAS-CG17197.ORF-CC}ZH-21F

F000256

M{UAS-CG17197.ORF.3xHA.GW}ZH-86Fb

v106296

v1433

v1434

v341875

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD01063}attP40/CyO-GFP

Genomic Clones (14)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (4)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0039367

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

DMG6-chr3R.37.011.pred.a

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0039367

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

43111

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Additional comments

One or more of the processed

(FlyBase Genome Annotators, 2013)

transcripts for these genes contain two non-overlapping open reading frames (ORFs). The non-overlapping

(FlyBase Genome Annotators, 2013)

ORFs are represented by CG17197 (FBgn0039367), CG17198 (FBgn0039366).

(FlyBase Genome Annotators, 2013)

CG17196 appears to be a chimeric gene, with the 5' part of the gene derived from CG17197 and the 3' part of the gene derived from CG17195.

(Rogers and Hartl, 2012)

"CG17196" is a putative chimeric gene derived from the "CG17197" and "CG17195" genes (where coding sequences of the two parental genes contribute to the coding sequence of the chimeric gene).

(Rogers et al., 2009)

Other Comments

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 20 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

43111

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

AAF56503

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q9VBM7

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0039367

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0039367

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG17197_1

Flygut - An atlas of the Drosophila adult midgut

FBgn0039367

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

43111

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC006858

InterPro - A database of protein families, domains and functional sites

Palmitoyltransferase, DHHC domain

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG17197

modMine - A data warehouse for the modENCODE project

FBgn0039367

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0039367

DRSC - Results frm RNAi screens

FBgn0039367

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0039367

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG17197-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0039367

FlyMine - An integrated database for Drosophila genomics

FBgn0039367

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CG17197

(Bischof et al., 2018, Schertel et al., 2015, FlyBase Genome Annotators, 2013, Chen et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Rogers and Hartl, 2012, Zhang et al., 2010, Keleman et al., 2009.8.5, Bannan et al., 2008, Hoskins et al., 2005)

CG17197-PA

(Rogers et al., 2009)

Name Synonyms

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (27)

Report Sections

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